{"error":"none","results":[{"aa_position":[],"accession":"XM_054373858","definition":"PREDICTED: Homo sapiens piwi like RNA-mediated gene silencing 1 (PIWIL1), transcript variant X7, mRNA.","division":"RefSeq","geneid":"9271","gi":"","length":"2688","nt_position":[],"snippet":"misc_feature <213..317 /gene=\"PIWIL1\" /gene_synonym=\"CT80.1; HIWI; MIWI; PIWI\" /note=\"PAZ domain, named PAZ after the proteins Piwi Argonaut and Zwille. PAZ is found in two families of proteins that are essential components of RNA-mediated gene-silencing pathways, including RNA interference, the piwi and Dicer families. PAZ functions as a...; Region: PAZ; cl00301\" /db_xref=\"CDD:469713\" misc_feature 273..1604 /gene=\"PIWIL1\" /gene_synonym=\"CT80.1; HIWI; MIWI; PIWI\" /note=\"PIWI domain, Piwi-like subfamily found in eukaryotes. This domain is found in Piwi and closely related proteins, where it is...","source":"Homo sapiens (human)","symbol":"PIWIL1","synonym":"CT80.1; HIWI; MIWI; PIWI","version":"XM_054373858.1"},{"aa_position":[],"accession":"XM_054334829","definition":"PREDICTED: Homo sapiens argonaute RISC component 4 (AGO4), transcript variant X7, mRNA.","division":"RefSeq","geneid":"192670","gi":"","length":"6410","nt_position":[],"snippet":"misc_feature 191..553 /gene=\"AGO4\" /gene_synonym=\"EIF2C4\" /note=\"PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille; Region: PAZ_argonaute_like; cd02846\" /db_xref=\"CDD:239212\" misc_feature order(347..349,392..394,434..436,446..448,500..502, 521..523,527..529) /gene=\"AGO4\" /gene_synonym=\"EIF2C4\" /note=\"nucleic acid-binding interface [nucleotide binding]; other site\" /db_xref=\"CDD:239212\" misc_...","source":"Homo sapiens (human)","symbol":"AGO4","synonym":"EIF2C4","version":"XM_054334829.1"},{"aa_position":[],"accession":"XM_054334824","definition":"PREDICTED: Homo sapiens argonaute RISC catalytic component 3 (AGO3), transcript variant X6, mRNA.","division":"RefSeq","geneid":"192669","gi":"","length":"18736","nt_position":[],"snippet":"misc_feature 100..441 /gene=\"AGO3\" /gene_synonym=\"EIF2C3\" /note=\"PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille; Region: PAZ_argonaute_like; cd02846\" /db_xref=\"CDD:239212\" misc_feature order(235..237,280..282,322..324,334..336,388..390, 409..411,415..417) /gene=\"AGO3\" /gene_synonym=\"EIF2C3\" /note=\"nucleic acid-binding interface [nucleotide binding]; other site\" /db_xref=\"CDD:239212\" misc_...","source":"Homo sapiens (human)","symbol":"AGO3","synonym":"EIF2C3","version":"XM_054334824.1"},{"aa_position":[],"accession":"XM_054334823","definition":"PREDICTED: Homo sapiens argonaute RISC catalytic component 3 (AGO3), transcript variant X5, mRNA.","division":"RefSeq","geneid":"192669","gi":"","length":"19691","nt_position":[],"snippet":"misc_feature 1055..1396 /gene=\"AGO3\" /gene_synonym=\"EIF2C3\" /note=\"PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille; Region: PAZ_argonaute_like; cd02846\" /db_xref=\"CDD:239212\" misc_feature order(1190..1192,1235..1237,1277..1279,1289..1291, 1343..1345,1364..1366,1370..1372) /gene=\"AGO3\" /gene_synonym=\"EIF2C3\" /note=\"nucleic acid-binding interface [nucleotide binding]; other site\" /db_xref=\"CDD...","source":"Homo sapiens (human)","symbol":"AGO3","synonym":"EIF2C3","version":"XM_054334823.1"},{"aa_position":[],"accession":"XM_054334822","definition":"PREDICTED: Homo sapiens argonaute RISC catalytic component 3 (AGO3), transcript variant X4, mRNA.","division":"RefSeq","geneid":"192669","gi":"","length":"19686","nt_position":[],"snippet":"misc_feature 1050..1391 /gene=\"AGO3\" /gene_synonym=\"EIF2C3\" /note=\"PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille; Region: PAZ_argonaute_like; cd02846\" /db_xref=\"CDD:239212\" misc_feature order(1185..1187,1230..1232,1272..1274,1284..1286, 1338..1340,1359..1361,1365..1367) /gene=\"AGO3\" /gene_synonym=\"EIF2C3\" /note=\"nucleic acid-binding interface [nucleotide binding]; other site\" /db_xref=\"CDD...","source":"Homo sapiens (human)","symbol":"AGO3","synonym":"EIF2C3","version":"XM_054334822.1"},{"aa_position":[],"accession":"XM_054334828","definition":"PREDICTED: Homo sapiens argonaute RISC component 4 (AGO4), transcript variant X6, mRNA.","division":"RefSeq","geneid":"192670","gi":"","length":"6547","nt_position":[],"snippet":"linker 1 domain; Region: ArgoL1; pfam08699\" /db_xref=\"CDD:462567\" misc_feature 328..690 /gene=\"AGO4\" /gene_synonym=\"EIF2C4\" /note=\"PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille; Region: PAZ_argonaute_like; cd02846\" /db_xref=\"CDD:239212\" misc_feature order(484..486,529..531,571..573,583..585,637..639, 658..660,664..666) /gene=\"AGO4\" /gene_synonym=\"EIF2C4\" /note=\"nucleic acid-binding...","source":"Homo sapiens (human)","symbol":"AGO4","synonym":"EIF2C4","version":"XM_054334828.1"},{"aa_position":[],"accession":"XM_054334827","definition":"PREDICTED: Homo sapiens argonaute RISC component 4 (AGO4), transcript variant X5, mRNA.","division":"RefSeq","geneid":"192670","gi":"","length":"6754","nt_position":[],"snippet":"linker 1 domain; Region: ArgoL1; pfam08699\" /db_xref=\"CDD:462567\" misc_feature 535..897 /gene=\"AGO4\" /gene_synonym=\"EIF2C4\" /note=\"PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille; Region: PAZ_argonaute_like; cd02846\" /db_xref=\"CDD:239212\" misc_feature order(691..693,736..738,778..780,790..792,844..846, 865..867,871..873) /gene=\"AGO4\" /gene_synonym=\"EIF2C4\" /note=\"nucleic acid-binding...","source":"Homo sapiens (human)","symbol":"AGO4","synonym":"EIF2C4","version":"XM_054334827.1"},{"aa_position":[],"accession":"XM_054334826","definition":"PREDICTED: Homo sapiens argonaute RISC component 4 (AGO4), transcript variant X4, mRNA.","division":"RefSeq","geneid":"192670","gi":"","length":"6937","nt_position":[],"snippet":"linker 1 domain; Region: ArgoL1; pfam08699\" /db_xref=\"CDD:462567\" misc_feature 718..1080 /gene=\"AGO4\" /gene_synonym=\"EIF2C4\" /note=\"PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille; Region: PAZ_argonaute_like; cd02846\" /db_xref=\"CDD:239212\" misc_feature order(874..876,919..921,961..963,973..975,1027..1029, 1048..1050,1054..1056) /gene=\"AGO4\" /gene_synonym=\"EIF2C4\" /note=\"nucleic acid-binding...","source":"Homo sapiens (human)","symbol":"AGO4","synonym":"EIF2C4","version":"XM_054334826.1"},{"aa_position":[],"accession":"XM_054334821","definition":"PREDICTED: Homo sapiens argonaute RISC catalytic component 3 (AGO3), transcript variant X3, mRNA.","division":"RefSeq","geneid":"192669","gi":"","length":"20566","nt_position":[],"snippet":"linker 1 domain; Region: ArgoL1; pfam08699\" /db_xref=\"CDD:462567\" misc_feature 1909..2271 /gene=\"AGO3\" /gene_synonym=\"EIF2C3\" /note=\"PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille; Region: PAZ_argonaute_like; cd02846\" /db_xref=\"CDD:239212\" misc_feature order(2065..2067,2110..2112,2152..2154,2164..2166, 2218..2220,2239..2241,2245..2247) /gene=\"AGO3\" /gene_synonym=\"EIF2C3\" /note=\"nucleic acid...","source":"Homo sapiens (human)","symbol":"AGO3","synonym":"EIF2C3","version":"XM_054334821.1"},{"aa_position":[],"accession":"XM_054334820","definition":"PREDICTED: Homo sapiens argonaute RISC catalytic component 3 (AGO3), transcript variant X2, mRNA.","division":"RefSeq","geneid":"192669","gi":"","length":"19631","nt_position":[],"snippet":"linker 1 domain; Region: ArgoL1; pfam08699\" /db_xref=\"CDD:462567\" misc_feature 974..1336 /gene=\"AGO3\" /gene_synonym=\"EIF2C3\" /note=\"PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille; Region: PAZ_argonaute_like; cd02846\" /db_xref=\"CDD:239212\" misc_feature order(1130..1132,1175..1177,1217..1219,1229..1231, 1283..1285,1304..1306,1310..1312) /gene=\"AGO3\" /gene_synonym=\"EIF2C3\" /note=\"nucleic acid-...","source":"Homo sapiens (human)","symbol":"AGO3","synonym":"EIF2C3","version":"XM_054334820.1"},{"aa_position":[],"accession":"XM_054334819","definition":"PREDICTED: Homo sapiens argonaute RISC catalytic component 3 (AGO3), transcript variant X1, mRNA.","division":"RefSeq","geneid":"192669","gi":"","length":"19797","nt_position":[],"snippet":"linker 1 domain; Region: ArgoL1; pfam08699\" /db_xref=\"CDD:462567\" misc_feature 1140..1502 /gene=\"AGO3\" /gene_synonym=\"EIF2C3\" /note=\"PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille; Region: PAZ_argonaute_like; cd02846\" /db_xref=\"CDD:239212\" misc_feature order(1296..1298,1341..1343,1383..1385,1395..1397, 1449..1451,1470..1472,1476..1478) /gene=\"AGO3\" /gene_synonym=\"EIF2C3\" /note=\"nucleic acid...","source":"Homo sapiens (human)","symbol":"AGO3","synonym":"EIF2C3","version":"XM_054334819.1"},{"aa_position":[],"accession":"XM_054360301","definition":"PREDICTED: Homo sapiens argonaute RISC catalytic component 2 (AGO2), transcript variant X5, mRNA.","division":"RefSeq","geneid":"27161","gi":"","length":"14572","nt_position":[],"snippet":"pfam08699\" /db_xref=\"CDD:462567\" misc_feature 778..1140 /gene=\"AGO2\" /gene_synonym=\"CASC7; EIF2C2; LESKRES; LINC00980; PPD; Q10\" /note=\"PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille; Region: PAZ_argonaute_like; cd02846\" /db_xref=\"CDD:239212\" misc_feature order(934..936,979..981,1021..1023,1033..1035,1087..1089, 1108..1110,1114..1116) /gene=\"AGO2\" /gene_synonym=\"CASC7; EIF2C2; LESKRES;...","source":"Homo sapiens (human)","symbol":"AGO2","synonym":"CASC7; EIF2C2; LESKRES; LINC00980; PPD; Q10","version":"XM_054360301.1"},{"aa_position":[],"accession":"XM_054360299","definition":"PREDICTED: Homo sapiens argonaute RISC catalytic component 2 (AGO2), transcript variant X3, mRNA.","division":"RefSeq","geneid":"27161","gi":"","length":"20032","nt_position":[],"snippet":"pfam08699\" /db_xref=\"CDD:462567\" misc_feature 6238..6600 /gene=\"AGO2\" /gene_synonym=\"CASC7; EIF2C2; LESKRES; LINC00980; PPD; Q10\" /note=\"PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille; Region: PAZ_argonaute_like; cd02846\" /db_xref=\"CDD:239212\" misc_feature order(6394..6396,6439..6441,6481..6483,6493..6495, 6547..6549,6568..6570,6574..6576) /gene=\"AGO2\" /gene_synonym=\"CASC7; EIF2C2; LESKRES...","source":"Homo sapiens (human)","symbol":"AGO2","synonym":"CASC7; EIF2C2; LESKRES; LINC00980; PPD; Q10","version":"XM_054360299.1"},{"aa_position":[],"accession":"XM_054360297","definition":"PREDICTED: Homo sapiens argonaute RISC catalytic component 2 (AGO2), transcript variant X1, mRNA.","division":"RefSeq","geneid":"27161","gi":"","length":"22227","nt_position":[],"snippet":"pfam08699\" /db_xref=\"CDD:462567\" misc_feature 8433..8795 /gene=\"AGO2\" /gene_synonym=\"CASC7; EIF2C2; LESKRES; LINC00980; PPD; Q10\" /note=\"PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille; Region: PAZ_argonaute_like; cd02846\" /db_xref=\"CDD:239212\" misc_feature order(8589..8591,8634..8636,8676..8678,8688..8690, 8742..8744,8763..8765,8769..8771) /gene=\"AGO2\" /gene_synonym=\"CASC7; EIF2C2; LESKRES...","source":"Homo sapiens (human)","symbol":"AGO2","synonym":"CASC7; EIF2C2; LESKRES; LINC00980; PPD; Q10","version":"XM_054360297.1"},{"aa_position":[],"accession":"XM_054360300","definition":"PREDICTED: Homo sapiens argonaute RISC catalytic component 2 (AGO2), transcript variant X4, mRNA.","division":"RefSeq","geneid":"27161","gi":"","length":"14718","nt_position":[],"snippet":"pfam08699\" /db_xref=\"CDD:462567\" misc_feature 924..1286 /gene=\"AGO2\" /gene_synonym=\"CASC7; EIF2C2; LESKRES; LINC00980; PPD; Q10\" /note=\"PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille; Region: PAZ_argonaute_like; cd02846\" /db_xref=\"CDD:239212\" misc_feature order(1080..1082,1125..1127,1167..1169,1179..1181, 1233..1235,1254..1256,1260..1262) /gene=\"AGO2\" /gene_synonym=\"CASC7; EIF2C2; LESKRES;...","source":"Homo sapiens (human)","symbol":"AGO2","synonym":"CASC7; EIF2C2; LESKRES; LINC00980; PPD; Q10","version":"XM_054360300.1"},{"aa_position":[],"accession":"XM_054335969","definition":"PREDICTED: Homo sapiens argonaute RISC component 1 (AGO1), transcript variant X1, mRNA.","division":"RefSeq","geneid":"26523","gi":"","length":"13722","nt_position":[],"snippet":"pfam08699\" /db_xref=\"CDD:462567\" misc_feature 886..1248 /gene=\"AGO1\" /gene_synonym=\"EIF2C; EIF2C1; GERP95; hAgo1; NEDLBAS; Q99\" /note=\"PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille; Region: PAZ_argonaute_like; cd02846\" /db_xref=\"CDD:239212\" misc_feature order(1042..1044,1087..1089,1129..1131,1141..1143, 1195..1197,1216..1218,1222..1224) /gene=\"AGO1\" /gene_synonym=\"EIF2C; EIF2C1; GERP95;...","source":"Homo sapiens (human)","symbol":"AGO1","synonym":"EIF2C; EIF2C1; GERP95; hAgo1; NEDLBAS; Q99","version":"XM_054335969.1"},{"aa_position":[],"accession":"NM_001410774","definition":"Homo sapiens actin related protein 8 (ACTR8), transcript variant 2, mRNA.","division":"RefSeq","geneid":"93973","gi":"","length":"3579","nt_position":[],"snippet":"H. and Harata,M. TITLE The actin-related protein hArp8 accumulates on the mitotic chromosomes and functions in chromosome alignment JOURNAL Exp Cell Res 314 (4), 859-868 (2008) PUBMED 18163988 REMARK GeneRIF: Expression of truncated hArp8 proteins and depletion of endogenous hArp8 by RNA interference caused misalignment of mitotic chromosomes, suggesting that chromosome-associated hArp8 has a role in chromosome behavior. REFERENCE 8 (bases 1 to 3579) AUTHORS Wu,S., Shi,Y., Mulligan,P., Gay,F., Landry,J., Liu,H., Lu,J., Qi,H.H., Wang,W., Nickoloff,J.A., Wu,C. and Shi,Y. TITLE A YY1-INO80...","source":"Homo sapiens (human)","symbol":"ACTR8","synonym":"ARP8; hArp8; INO80N","version":"NM_001410774.1"},{"aa_position":[],"accession":"NM_001414464","definition":"Homo sapiens transmembrane BAX inhibitor motif containing 6 (TMBIM6), transcript variant 5, mRNA.","division":"RefSeq","geneid":"7009","gi":"","length":"2994","nt_position":[],"snippet":"human interactome JOURNAL Cell 184 (11), 3022-3040 (2021) PUBMED 33961781 REFERENCE 6 (bases 1 to 2994) AUTHORS Grzmil,M., Thelen,P., Hemmerlein,B., Schweyer,S., Voigt,S., Mury,D. and Burfeind,P. TITLE Bax inhibitor-1 is overexpressed in prostate cancer and its specific down-regulation by RNA interference leads to cell death in human prostate carcinoma cells JOURNAL Am J Pathol 163 (2), 543-552 (2003) PUBMED 12875974 REMARK GeneRIF: Results indicate that the human Bax inhibitor-1 gene may serve as a prostate cancer expression marker based on its overexpression in prostate carcinoma and...","source":"Homo sapiens (human)","symbol":"TMBIM6","synonym":"BAXI1; BI-1; TEGT","version":"NM_001414464.1"},{"aa_position":[],"accession":"NM_001414462","definition":"Homo sapiens transmembrane BAX inhibitor motif containing 6 (TMBIM6), transcript variant 3, mRNA.","division":"RefSeq","geneid":"7009","gi":"","length":"2996","nt_position":[],"snippet":"human interactome JOURNAL Cell 184 (11), 3022-3040 (2021) PUBMED 33961781 REFERENCE 6 (bases 1 to 2996) AUTHORS Grzmil,M., Thelen,P., Hemmerlein,B., Schweyer,S., Voigt,S., Mury,D. and Burfeind,P. TITLE Bax inhibitor-1 is overexpressed in prostate cancer and its specific down-regulation by RNA interference leads to cell death in human prostate carcinoma cells JOURNAL Am J Pathol 163 (2), 543-552 (2003) PUBMED 12875974 REMARK GeneRIF: Results indicate that the human Bax inhibitor-1 gene may serve as a prostate cancer expression marker based on its overexpression in prostate carcinoma and...","source":"Homo sapiens (human)","symbol":"TMBIM6","synonym":"BAXI1; BI-1; TEGT","version":"NM_001414462.1"},{"aa_position":[],"accession":"NM_001414463","definition":"Homo sapiens transmembrane BAX inhibitor motif containing 6 (TMBIM6), transcript variant 4, mRNA.","division":"RefSeq","geneid":"7009","gi":"","length":"3166","nt_position":[],"snippet":"human interactome JOURNAL Cell 184 (11), 3022-3040 (2021) PUBMED 33961781 REFERENCE 6 (bases 1 to 3166) AUTHORS Grzmil,M., Thelen,P., Hemmerlein,B., Schweyer,S., Voigt,S., Mury,D. and Burfeind,P. TITLE Bax inhibitor-1 is overexpressed in prostate cancer and its specific down-regulation by RNA interference leads to cell death in human prostate carcinoma cells JOURNAL Am J Pathol 163 (2), 543-552 (2003) PUBMED 12875974 REMARK GeneRIF: Results indicate that the human Bax inhibitor-1 gene may serve as a prostate cancer expression marker based on its overexpression in prostate carcinoma and...","source":"Homo sapiens (human)","symbol":"TMBIM6","synonym":"BAXI1; BI-1; TEGT","version":"NM_001414463.1"},{"aa_position":[],"accession":"NM_001425285","definition":"Homo sapiens retrotransposon Gag like 1 (RTL1), transcript variant 2, mRNA.","division":"RefSeq","geneid":"388015","gi":"","length":"5336","nt_position":[],"snippet":"retrotransposon-derived, paternally expressed imprinted gene that is highly expressed at the late fetal stage in both the fetus and placenta. It has an overlapping maternally expressed antisense transcript, which contains several microRNAs targeting the transcripts of this gene through an RNA interference (RNAi) mechanism. This gene is essential for maintenance of the fetal capillaries. [provided by RefSeq, Jul 2009]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##...","source":"Homo sapiens (human)","symbol":"RTL1","synonym":"HUR1; Mar1; MART1; PEG11; SIRH2","version":"NM_001425285.1"},{"aa_position":[],"accession":"NR_038205","definition":"Homo sapiens CFAP418 antisense RNA 1 (CFAP418-AS1), transcript variant 5, long non-coding RNA.","division":"RefSeq","geneid":"100616530","gi":"","length":"219","nt_position":[],"snippet":"Clarke RA. TITLE Transcriptional Interference Regulates the Evolutionary Development of Speech JOURNAL Genes (Basel) 13 (7), 1195 (2022) PUBMED 35885978 REMARK Publication Status: Online-Only REFERENCE 2 (bases 1 to 219) AUTHORS Fang Z, Zhao Z, Eapen V and Clarke RA. TITLE siRNA Mediate RNA Interference Concordant with Early On-Target Transient Transcriptional Interference JOURNAL Genes (Basel) 12 (8), 1290 (2021) PUBMED 34440463 REMARK Publication Status: Online-Only REFERENCE 3 (bases 1 to 219) AUTHORS Wade TD, Gordon S, Medland S, Bulik CM, Heath AC, Montgomery GW and Martin NG. TITLE...","source":"Homo sapiens (human)","symbol":"CFAP418-AS1","synonym":"C8orf37-AS1","version":"NR_038205.1"},{"aa_position":[],"accession":"NM_001441339","definition":"Homo sapiens bromodomain and WD repeat domain containing 3 (BRWD3), transcript variant 2, mRNA.","division":"RefSeq","geneid":"254065","gi":"","length":"12771","nt_position":[],"snippet":"and may cause disease by altering intracellular signaling pathways affecting cellular proliferation. REFERENCE 9 (bases 1 to 12771) AUTHORS Muller,P., Kuttenkeuler,D., Gesellchen,V., Zeidler,M.P. and Boutros,M. TITLE Identification of JAK/STAT signalling components by genome-wide RNA interference JOURNAL Nature 436 (7052), 871-875 (2005) PUBMED 16094372 REFERENCE 10 (bases 1 to 12771) AUTHORS Kalla,C., Nentwich,H., Schlotter,M., Mertens,D., Wildenberger,K., Dohner,H., Stilgenbauer,S. and Lichter,P. TITLE Translocation t(X;11)(q13;q23) in B-cell chronic lymphocytic leukemia disrupts two novel...","source":"Homo sapiens (human)","symbol":"BRWD3","synonym":"BRODL; DCAF20; MRX93; XLID93","version":"NM_001441339.1"},{"aa_position":[],"accession":"NR_038207","definition":"Homo sapiens CFAP418 antisense RNA 1 (CFAP418-AS1), transcript variant 7, long non-coding RNA.","division":"RefSeq","geneid":"100616530","gi":"","length":"335","nt_position":[],"snippet":"Clarke RA. TITLE Transcriptional Interference Regulates the Evolutionary Development of Speech JOURNAL Genes (Basel) 13 (7), 1195 (2022) PUBMED 35885978 REMARK Publication Status: Online-Only REFERENCE 2 (bases 1 to 335) AUTHORS Fang Z, Zhao Z, Eapen V and Clarke RA. TITLE siRNA Mediate RNA Interference Concordant with Early On-Target Transient Transcriptional Interference JOURNAL Genes (Basel) 12 (8), 1290 (2021) PUBMED 34440463 REMARK Publication Status: Online-Only REFERENCE 3 (bases 1 to 335) AUTHORS Wade TD, Gordon S, Medland S, Bulik CM, Heath AC, Montgomery GW and Martin NG. TITLE...","source":"Homo sapiens (human)","symbol":"CFAP418-AS1","synonym":"C8orf37-AS1","version":"NR_038207.1"},{"aa_position":[],"accession":"NR_038208","definition":"Homo sapiens CFAP418 antisense RNA 1 (CFAP418-AS1), transcript variant 8, long non-coding RNA.","division":"RefSeq","geneid":"100616530","gi":"","length":"310","nt_position":[],"snippet":"Clarke RA. TITLE Transcriptional Interference Regulates the Evolutionary Development of Speech JOURNAL Genes (Basel) 13 (7), 1195 (2022) PUBMED 35885978 REMARK Publication Status: Online-Only REFERENCE 2 (bases 1 to 310) AUTHORS Fang Z, Zhao Z, Eapen V and Clarke RA. TITLE siRNA Mediate RNA Interference Concordant with Early On-Target Transient Transcriptional Interference JOURNAL Genes (Basel) 12 (8), 1290 (2021) PUBMED 34440463 REMARK Publication Status: Online-Only REFERENCE 3 (bases 1 to 310) AUTHORS Wade TD, Gordon S, Medland S, Bulik CM, Heath AC, Montgomery GW and Martin NG. TITLE...","source":"Homo sapiens (human)","symbol":"CFAP418-AS1","synonym":"C8orf37-AS1","version":"NR_038208.1"},{"aa_position":[],"accession":"NR_038209","definition":"Homo sapiens CFAP418 antisense RNA 1 (CFAP418-AS1), transcript variant 9, long non-coding RNA.","division":"RefSeq","geneid":"100616530","gi":"","length":"377","nt_position":[],"snippet":"Clarke RA. TITLE Transcriptional Interference Regulates the Evolutionary Development of Speech JOURNAL Genes (Basel) 13 (7), 1195 (2022) PUBMED 35885978 REMARK Publication Status: Online-Only REFERENCE 2 (bases 1 to 377) AUTHORS Fang Z, Zhao Z, Eapen V and Clarke RA. TITLE siRNA Mediate RNA Interference Concordant with Early On-Target Transient Transcriptional Interference JOURNAL Genes (Basel) 12 (8), 1290 (2021) PUBMED 34440463 REMARK Publication Status: Online-Only REFERENCE 3 (bases 1 to 377) AUTHORS Wade TD, Gordon S, Medland S, Bulik CM, Heath AC, Montgomery GW and Martin NG. TITLE...","source":"Homo sapiens (human)","symbol":"CFAP418-AS1","synonym":"C8orf37-AS1","version":"NR_038209.1"},{"aa_position":[],"accession":"NR_038204","definition":"Homo sapiens CFAP418 antisense RNA 1 (CFAP418-AS1), transcript variant 4, long non-coding RNA.","division":"RefSeq","geneid":"100616530","gi":"","length":"374","nt_position":[],"snippet":"Clarke RA. TITLE Transcriptional Interference Regulates the Evolutionary Development of Speech JOURNAL Genes (Basel) 13 (7), 1195 (2022) PUBMED 35885978 REMARK Publication Status: Online-Only REFERENCE 2 (bases 1 to 374) AUTHORS Fang Z, Zhao Z, Eapen V and Clarke RA. TITLE siRNA Mediate RNA Interference Concordant with Early On-Target Transient Transcriptional Interference JOURNAL Genes (Basel) 12 (8), 1290 (2021) PUBMED 34440463 REMARK Publication Status: Online-Only REFERENCE 3 (bases 1 to 374) AUTHORS Wade TD, Gordon S, Medland S, Bulik CM, Heath AC, Montgomery GW and Martin NG. TITLE...","source":"Homo sapiens (human)","symbol":"CFAP418-AS1","synonym":"C8orf37-AS1","version":"NR_038204.1"},{"aa_position":[],"accession":"NR_038206","definition":"Homo sapiens CFAP418 antisense RNA 1 (CFAP418-AS1), transcript variant 6, long non-coding RNA.","division":"RefSeq","geneid":"100616530","gi":"","length":"388","nt_position":[],"snippet":"Clarke RA. TITLE Transcriptional Interference Regulates the Evolutionary Development of Speech JOURNAL Genes (Basel) 13 (7), 1195 (2022) PUBMED 35885978 REMARK Publication Status: Online-Only REFERENCE 2 (bases 1 to 388) AUTHORS Fang Z, Zhao Z, Eapen V and Clarke RA. TITLE siRNA Mediate RNA Interference Concordant with Early On-Target Transient Transcriptional Interference JOURNAL Genes (Basel) 12 (8), 1290 (2021) PUBMED 34440463 REMARK Publication Status: Online-Only REFERENCE 3 (bases 1 to 388) AUTHORS Wade TD, Gordon S, Medland S, Bulik CM, Heath AC, Montgomery GW and Martin NG. TITLE...","source":"Homo sapiens (human)","symbol":"CFAP418-AS1","synonym":"C8orf37-AS1","version":"NR_038206.1"},{"aa_position":[],"accession":"NR_125391","definition":"Homo sapiens DIAPH2 antisense RNA 1 (DIAPH2-AS1), long non-coding RNA.","division":"RefSeq","geneid":"10824","gi":"","length":"977","nt_position":[],"snippet":"A. TITLE HOXD8/DIAPH2-AS1 epigenetically regulates PAX3 and impairs HTR-8/SVneo cell function under hypoxia JOURNAL Biosci Rep 39 (1) (2019) PUBMED 30626726 REMARK GeneRIF: Two transcription factors, HOXD8 and Lhx3, predicted to regulate the expression of lncRNAs, were also selected. Using RNA interference technology, HOXD8 and Lhx3 were found to positively regulate DIAPH2-AS1 and RP11-445K13.2 in HTR-8/SVneo cells Publication Status: Online-Only REFERENCE 3 (bases 1 to 977) AUTHORS Oshikawa,M., Tsutsui,C., Ikegami,T., Fuchida,Y., Matsubara,M., Toyama,S., Usami,R., Ohtoko,K. and Kato,S. TITLE...","source":"Homo sapiens (human)","symbol":"DIAPH2-AS1","synonym":"EPAG","version":"NR_125391.1"},{"aa_position":[],"accession":"NM_001349369","definition":"Homo sapiens centromere protein K (CENPK), transcript variant 5, mRNA.","division":"RefSeq","geneid":"64105","gi":"","length":"1125","nt_position":[],"snippet":"REMARK GeneRIF: CENPK orchestrates ovarian cancer progression via GOLPH3-Mediated activation of mTOR signaling. REFERENCE 3 (bases 1 to 1125) AUTHORS Li,X., Han,Y.R., Xuefeng,X., Ma,Y.X., Xing,G.S., Yang,Z.W., Zhang,Z., Shi,L. and Wu,X.L. TITLE Lentivirus-mediated short hairpin RNA interference of CENPK inhibits growth of colorectal cancer cells with overexpression of Cullin 4A JOURNAL World J Gastroenterol 28 (37), 5420-5443 (2022) PUBMED 36312839 REMARK GeneRIF: Lentivirus-mediated short hairpin RNA interference of CENPK inhibits growth of colorectal cancer cells with overexpression of...","source":"Homo sapiens (human)","symbol":"CENPK","synonym":"AF5alpha; CENP-K; FKSG14; P33; Solt","version":"NM_001349369.2"},{"aa_position":[],"accession":"NR_038203","definition":"Homo sapiens CFAP418 antisense RNA 1 (CFAP418-AS1), transcript variant 3, long non-coding RNA.","division":"RefSeq","geneid":"100616530","gi":"","length":"445","nt_position":[],"snippet":"Clarke RA. TITLE Transcriptional Interference Regulates the Evolutionary Development of Speech JOURNAL Genes (Basel) 13 (7), 1195 (2022) PUBMED 35885978 REMARK Publication Status: Online-Only REFERENCE 2 (bases 1 to 445) AUTHORS Fang Z, Zhao Z, Eapen V and Clarke RA. TITLE siRNA Mediate RNA Interference Concordant with Early On-Target Transient Transcriptional Interference JOURNAL Genes (Basel) 12 (8), 1290 (2021) PUBMED 34440463 REMARK Publication Status: Online-Only REFERENCE 3 (bases 1 to 445) AUTHORS Wade TD, Gordon S, Medland S, Bulik CM, Heath AC, Montgomery GW and Martin NG. TITLE...","source":"Homo sapiens (human)","symbol":"CFAP418-AS1","synonym":"C8orf37-AS1","version":"NR_038203.1"},{"aa_position":[],"accession":"NR_038202","definition":"Homo sapiens CFAP418 antisense RNA 1 (CFAP418-AS1), transcript variant 2, long non-coding RNA.","division":"RefSeq","geneid":"100616530","gi":"","length":"529","nt_position":[],"snippet":"Clarke RA. TITLE Transcriptional Interference Regulates the Evolutionary Development of Speech JOURNAL Genes (Basel) 13 (7), 1195 (2022) PUBMED 35885978 REMARK Publication Status: Online-Only REFERENCE 2 (bases 1 to 529) AUTHORS Fang Z, Zhao Z, Eapen V and Clarke RA. TITLE siRNA Mediate RNA Interference Concordant with Early On-Target Transient Transcriptional Interference JOURNAL Genes (Basel) 12 (8), 1290 (2021) PUBMED 34440463 REMARK Publication Status: Online-Only REFERENCE 3 (bases 1 to 529) AUTHORS Wade TD, Gordon S, Medland S, Bulik CM, Heath AC, Montgomery GW and Martin NG. TITLE...","source":"Homo sapiens (human)","symbol":"CFAP418-AS1","synonym":"C8orf37-AS1","version":"NR_038202.1"},{"aa_position":[],"accession":"NR_038201","definition":"Homo sapiens CFAP418 antisense RNA 1 (CFAP418-AS1), transcript variant 1, long non-coding RNA.","division":"RefSeq","geneid":"100616530","gi":"","length":"600","nt_position":[],"snippet":"Clarke RA. TITLE Transcriptional Interference Regulates the Evolutionary Development of Speech JOURNAL Genes (Basel) 13 (7), 1195 (2022) PUBMED 35885978 REMARK Publication Status: Online-Only REFERENCE 2 (bases 1 to 600) AUTHORS Fang Z, Zhao Z, Eapen V and Clarke RA. TITLE siRNA Mediate RNA Interference Concordant with Early On-Target Transient Transcriptional Interference JOURNAL Genes (Basel) 12 (8), 1290 (2021) PUBMED 34440463 REMARK Publication Status: Online-Only REFERENCE 3 (bases 1 to 600) AUTHORS Wade TD, Gordon S, Medland S, Bulik CM, Heath AC, Montgomery GW and Martin NG. TITLE...","source":"Homo sapiens (human)","symbol":"CFAP418-AS1","synonym":"C8orf37-AS1","version":"NR_038201.1"},{"aa_position":[],"accession":"NM_001349368","definition":"Homo sapiens centromere protein K (CENPK), transcript variant 4, mRNA.","division":"RefSeq","geneid":"64105","gi":"","length":"1584","nt_position":[],"snippet":"REMARK GeneRIF: CENPK orchestrates ovarian cancer progression via GOLPH3-Mediated activation of mTOR signaling. REFERENCE 3 (bases 1 to 1584) AUTHORS Li,X., Han,Y.R., Xuefeng,X., Ma,Y.X., Xing,G.S., Yang,Z.W., Zhang,Z., Shi,L. and Wu,X.L. TITLE Lentivirus-mediated short hairpin RNA interference of CENPK inhibits growth of colorectal cancer cells with overexpression of Cullin 4A JOURNAL World J Gastroenterol 28 (37), 5420-5443 (2022) PUBMED 36312839 REMARK GeneRIF: Lentivirus-mediated short hairpin RNA interference of CENPK inhibits growth of colorectal cancer cells with overexpression of...","source":"Homo sapiens (human)","symbol":"CENPK","synonym":"AF5alpha; CENP-K; FKSG14; P33; Solt","version":"NM_001349368.2"},{"aa_position":[],"accession":"NM_001349367","definition":"Homo sapiens centromere protein K (CENPK), transcript variant 3, mRNA.","division":"RefSeq","geneid":"64105","gi":"","length":"1649","nt_position":[],"snippet":"REMARK GeneRIF: CENPK orchestrates ovarian cancer progression via GOLPH3-Mediated activation of mTOR signaling. REFERENCE 3 (bases 1 to 1649) AUTHORS Li,X., Han,Y.R., Xuefeng,X., Ma,Y.X., Xing,G.S., Yang,Z.W., Zhang,Z., Shi,L. and Wu,X.L. TITLE Lentivirus-mediated short hairpin RNA interference of CENPK inhibits growth of colorectal cancer cells with overexpression of Cullin 4A JOURNAL World J Gastroenterol 28 (37), 5420-5443 (2022) PUBMED 36312839 REMARK GeneRIF: Lentivirus-mediated short hairpin RNA interference of CENPK inhibits growth of colorectal cancer cells with overexpression of...","source":"Homo sapiens (human)","symbol":"CENPK","synonym":"AF5alpha; CENP-K; FKSG14; P33; Solt","version":"NM_001349367.2"},{"aa_position":[],"accession":"NM_001267038","definition":"Homo sapiens centromere protein K (CENPK), transcript variant 2, mRNA.","division":"RefSeq","geneid":"64105","gi":"","length":"1697","nt_position":[],"snippet":"REMARK GeneRIF: CENPK orchestrates ovarian cancer progression via GOLPH3-Mediated activation of mTOR signaling. REFERENCE 3 (bases 1 to 1697) AUTHORS Li,X., Han,Y.R., Xuefeng,X., Ma,Y.X., Xing,G.S., Yang,Z.W., Zhang,Z., Shi,L. and Wu,X.L. TITLE Lentivirus-mediated short hairpin RNA interference of CENPK inhibits growth of colorectal cancer cells with overexpression of Cullin 4A JOURNAL World J Gastroenterol 28 (37), 5420-5443 (2022) PUBMED 36312839 REMARK GeneRIF: Lentivirus-mediated short hairpin RNA interference of CENPK inhibits growth of colorectal cancer cells with overexpression of...","source":"Homo sapiens (human)","symbol":"CENPK","synonym":"AF5alpha; CENP-K; FKSG14; P33; Solt","version":"NM_001267038.2"},{"aa_position":[],"accession":"NM_022145","definition":"Homo sapiens centromere protein K (CENPK), transcript variant 1, mRNA.","division":"RefSeq","geneid":"64105","gi":"","length":"1731","nt_position":[],"snippet":"REMARK GeneRIF: CENPK orchestrates ovarian cancer progression via GOLPH3-Mediated activation of mTOR signaling. REFERENCE 3 (bases 1 to 1731) AUTHORS Li,X., Han,Y.R., Xuefeng,X., Ma,Y.X., Xing,G.S., Yang,Z.W., Zhang,Z., Shi,L. and Wu,X.L. TITLE Lentivirus-mediated short hairpin RNA interference of CENPK inhibits growth of colorectal cancer cells with overexpression of Cullin 4A JOURNAL World J Gastroenterol 28 (37), 5420-5443 (2022) PUBMED 36312839 REMARK GeneRIF: Lentivirus-mediated short hairpin RNA interference of CENPK inhibits growth of colorectal cancer cells with overexpression of...","source":"Homo sapiens (human)","symbol":"CENPK","synonym":"AF5alpha; CENP-K; FKSG14; P33; Solt","version":"NM_022145.5"},{"aa_position":[],"accession":"NM_001288569","definition":"Homo sapiens transmembrane protein 9 (TMEM9), transcript variant 7, mRNA.","division":"RefSeq","geneid":"252839","gi":"","length":"1505","nt_position":[],"snippet":"Wnt/beta-catenin signaling pathway is involved in the induction of these cytokine expressions. REFERENCE 7 (bases 1 to 1505) AUTHORS Zhang,Y., Ran,Y., Xiong,Y., Zhong,Z.B., Wang,Z.H., Fan,X.L. and Ye,Q.F. TITLE Effects of TMEM9 gene on cell progression in hepatocellular carcinoma by RNA interference JOURNAL Oncol Rep 36 (1), 299-305 (2016) PUBMED 27220462 REMARK GeneRIF: TMEM9 knockdown by RNA interference resulted in G1 arrest. REFERENCE 8 (bases 1 to 1505) AUTHORS Dodeller,F., Gottar,M., Huesken,D., Iourgenko,V. and Cenni,B. TITLE The lysosomal transmembrane protein 9B regulates the activity...","source":"Homo sapiens (human)","symbol":"TMEM9","synonym":"DERM4; TMEM9A","version":"NM_001288569.2"},{"aa_position":[],"accession":"NM_016456","definition":"Homo sapiens transmembrane protein 9 (TMEM9), transcript variant 1, mRNA.","division":"RefSeq","geneid":"252839","gi":"","length":"1509","nt_position":[],"snippet":"Wnt/beta-catenin signaling pathway is involved in the induction of these cytokine expressions. REFERENCE 7 (bases 1 to 1509) AUTHORS Zhang,Y., Ran,Y., Xiong,Y., Zhong,Z.B., Wang,Z.H., Fan,X.L. and Ye,Q.F. TITLE Effects of TMEM9 gene on cell progression in hepatocellular carcinoma by RNA interference JOURNAL Oncol Rep 36 (1), 299-305 (2016) PUBMED 27220462 REMARK GeneRIF: TMEM9 knockdown by RNA interference resulted in G1 arrest. REFERENCE 8 (bases 1 to 1509) AUTHORS Dodeller,F., Gottar,M., Huesken,D., Iourgenko,V. and Cenni,B. TITLE The lysosomal transmembrane protein 9B regulates the activity...","source":"Homo sapiens (human)","symbol":"TMEM9","synonym":"DERM4; TMEM9A","version":"NM_016456.5"},{"aa_position":[],"accession":"NM_001288570","definition":"Homo sapiens transmembrane protein 9 (TMEM9), transcript variant 8, mRNA.","division":"RefSeq","geneid":"252839","gi":"","length":"1518","nt_position":[],"snippet":"Wnt/beta-catenin signaling pathway is involved in the induction of these cytokine expressions. REFERENCE 7 (bases 1 to 1518) AUTHORS Zhang,Y., Ran,Y., Xiong,Y., Zhong,Z.B., Wang,Z.H., Fan,X.L. and Ye,Q.F. TITLE Effects of TMEM9 gene on cell progression in hepatocellular carcinoma by RNA interference JOURNAL Oncol Rep 36 (1), 299-305 (2016) PUBMED 27220462 REMARK GeneRIF: TMEM9 knockdown by RNA interference resulted in G1 arrest. REFERENCE 8 (bases 1 to 1518) AUTHORS Dodeller,F., Gottar,M., Huesken,D., Iourgenko,V. and Cenni,B. TITLE The lysosomal transmembrane protein 9B regulates the activity...","source":"Homo sapiens (human)","symbol":"TMEM9","synonym":"DERM4; TMEM9A","version":"NM_001288570.2"},{"aa_position":[],"accession":"NM_001288564","definition":"Homo sapiens transmembrane protein 9 (TMEM9), transcript variant 2, mRNA.","division":"RefSeq","geneid":"252839","gi":"","length":"1548","nt_position":[],"snippet":"Wnt/beta-catenin signaling pathway is involved in the induction of these cytokine expressions. REFERENCE 7 (bases 1 to 1548) AUTHORS Zhang,Y., Ran,Y., Xiong,Y., Zhong,Z.B., Wang,Z.H., Fan,X.L. and Ye,Q.F. TITLE Effects of TMEM9 gene on cell progression in hepatocellular carcinoma by RNA interference JOURNAL Oncol Rep 36 (1), 299-305 (2016) PUBMED 27220462 REMARK GeneRIF: TMEM9 knockdown by RNA interference resulted in G1 arrest. REFERENCE 8 (bases 1 to 1548) AUTHORS Dodeller,F., Gottar,M., Huesken,D., Iourgenko,V. and Cenni,B. TITLE The lysosomal transmembrane protein 9B regulates the activity...","source":"Homo sapiens (human)","symbol":"TMEM9","synonym":"DERM4; TMEM9A","version":"NM_001288564.2"},{"aa_position":[],"accession":"NM_022076","definition":"Homo sapiens dual specificity phosphatase 21 (DUSP21), mRNA.","division":"RefSeq","geneid":"63904","gi":"","length":"868","nt_position":[],"snippet":"variants across the allele frequency spectrum in human populations JOURNAL Nat Commun 10 (1), 4141 (2019) PUBMED 31515488 REMARK Publication Status: Online-Only REFERENCE 3 (bases 1 to 868) AUTHORS Deng,Q., Li,K.Y., Chen,H., Dai,J.H., Zhai,Y.Y., Wang,Q., Li,N., Wang,Y.P. and Han,Z.G. TITLE RNA interference against cancer/testis genes identifies dual specificity phosphatase 21 as a potential therapeutic target in human hepatocellular carcinoma JOURNAL Hepatology 59 (2), 518-530 (2014) PUBMED 23929653 REMARK GeneRIF: DUSP21 plays an important role in sustaining hepatocellular carcinoma (HCC)...","source":"Homo sapiens (human)","symbol":"DUSP21","synonym":"LMWDSP21","version":"NM_022076.4"},{"aa_position":[],"accession":"NM_001288571","definition":"Homo sapiens transmembrane protein 9 (TMEM9), transcript variant 9, mRNA.","division":"RefSeq","geneid":"252839","gi":"","length":"1584","nt_position":[],"snippet":"Wnt/beta-catenin signaling pathway is involved in the induction of these cytokine expressions. REFERENCE 7 (bases 1 to 1584) AUTHORS Zhang,Y., Ran,Y., Xiong,Y., Zhong,Z.B., Wang,Z.H., Fan,X.L. and Ye,Q.F. TITLE Effects of TMEM9 gene on cell progression in hepatocellular carcinoma by RNA interference JOURNAL Oncol Rep 36 (1), 299-305 (2016) PUBMED 27220462 REMARK GeneRIF: TMEM9 knockdown by RNA interference resulted in G1 arrest. REFERENCE 8 (bases 1 to 1584) AUTHORS Dodeller,F., Gottar,M., Huesken,D., Iourgenko,V. and Cenni,B. TITLE The lysosomal transmembrane protein 9B regulates the activity...","source":"Homo sapiens (human)","symbol":"TMEM9","synonym":"DERM4; TMEM9A","version":"NM_001288571.2"},{"aa_position":[],"accession":"NM_001288566","definition":"Homo sapiens transmembrane protein 9 (TMEM9), transcript variant 4, mRNA.","division":"RefSeq","geneid":"252839","gi":"","length":"1592","nt_position":[],"snippet":"Wnt/beta-catenin signaling pathway is involved in the induction of these cytokine expressions. REFERENCE 7 (bases 1 to 1592) AUTHORS Zhang,Y., Ran,Y., Xiong,Y., Zhong,Z.B., Wang,Z.H., Fan,X.L. and Ye,Q.F. TITLE Effects of TMEM9 gene on cell progression in hepatocellular carcinoma by RNA interference JOURNAL Oncol Rep 36 (1), 299-305 (2016) PUBMED 27220462 REMARK GeneRIF: TMEM9 knockdown by RNA interference resulted in G1 arrest. REFERENCE 8 (bases 1 to 1592) AUTHORS Dodeller,F., Gottar,M., Huesken,D., Iourgenko,V. and Cenni,B. TITLE The lysosomal transmembrane protein 9B regulates the activity...","source":"Homo sapiens (human)","symbol":"TMEM9","synonym":"DERM4; TMEM9A","version":"NM_001288566.2"},{"aa_position":[],"accession":"NM_001288568","definition":"Homo sapiens transmembrane protein 9 (TMEM9), transcript variant 6, mRNA.","division":"RefSeq","geneid":"252839","gi":"","length":"1644","nt_position":[],"snippet":"Wnt/beta-catenin signaling pathway is involved in the induction of these cytokine expressions. REFERENCE 7 (bases 1 to 1644) AUTHORS Zhang,Y., Ran,Y., Xiong,Y., Zhong,Z.B., Wang,Z.H., Fan,X.L. and Ye,Q.F. TITLE Effects of TMEM9 gene on cell progression in hepatocellular carcinoma by RNA interference JOURNAL Oncol Rep 36 (1), 299-305 (2016) PUBMED 27220462 REMARK GeneRIF: TMEM9 knockdown by RNA interference resulted in G1 arrest. REFERENCE 8 (bases 1 to 1644) AUTHORS Dodeller,F., Gottar,M., Huesken,D., Iourgenko,V. and Cenni,B. TITLE The lysosomal transmembrane protein 9B regulates the activity...","source":"Homo sapiens (human)","symbol":"TMEM9","synonym":"DERM4; TMEM9A","version":"NM_001288568.2"},{"aa_position":[],"accession":"NR_109920","definition":"Homo sapiens transmembrane protein 9 (TMEM9), transcript variant 10, non-coding RNA.","division":"RefSeq","geneid":"252839","gi":"","length":"1736","nt_position":[],"snippet":"Wnt/beta-catenin signaling pathway is involved in the induction of these cytokine expressions. REFERENCE 7 (bases 1 to 1736) AUTHORS Zhang,Y., Ran,Y., Xiong,Y., Zhong,Z.B., Wang,Z.H., Fan,X.L. and Ye,Q.F. TITLE Effects of TMEM9 gene on cell progression in hepatocellular carcinoma by RNA interference JOURNAL Oncol Rep 36 (1), 299-305 (2016) PUBMED 27220462 REMARK GeneRIF: TMEM9 knockdown by RNA interference resulted in G1 arrest. REFERENCE 8 (bases 1 to 1736) AUTHORS Dodeller,F., Gottar,M., Huesken,D., Iourgenko,V. and Cenni,B. TITLE The lysosomal transmembrane protein 9B regulates the activity...","source":"Homo sapiens (human)","symbol":"TMEM9","synonym":"DERM4; TMEM9A","version":"NR_109920.2"},{"aa_position":[],"accession":"NM_001288567","definition":"Homo sapiens transmembrane protein 9 (TMEM9), transcript variant 5, mRNA.","division":"RefSeq","geneid":"252839","gi":"","length":"1806","nt_position":[],"snippet":"Wnt/beta-catenin signaling pathway is involved in the induction of these cytokine expressions. REFERENCE 7 (bases 1 to 1806) AUTHORS Zhang,Y., Ran,Y., Xiong,Y., Zhong,Z.B., Wang,Z.H., Fan,X.L. and Ye,Q.F. TITLE Effects of TMEM9 gene on cell progression in hepatocellular carcinoma by RNA interference JOURNAL Oncol Rep 36 (1), 299-305 (2016) PUBMED 27220462 REMARK GeneRIF: TMEM9 knockdown by RNA interference resulted in G1 arrest. REFERENCE 8 (bases 1 to 1806) AUTHORS Dodeller,F., Gottar,M., Huesken,D., Iourgenko,V. and Cenni,B. TITLE The lysosomal transmembrane protein 9B regulates the activity...","source":"Homo sapiens (human)","symbol":"TMEM9","synonym":"DERM4; TMEM9A","version":"NM_001288567.2"},{"aa_position":[],"accession":"NM_016077","definition":"Homo sapiens peptidyl-tRNA hydrolase 2 (PTRH2), transcript variant 2, mRNA; nuclear gene for mitochondrial product.","division":"RefSeq","geneid":"51651","gi":"","length":"731","nt_position":[],"snippet":"Bit-1 mediates integrin-dependent cell survival through activation of the NFkappaB pathway REFERENCE 6 (bases 1 to 731) AUTHORS Fan,T., Jiang,G., Suo,Z., Liu,H., Xu,P., Ji,Z., Zhang,L. and Yang,G. TITLE Down-regulation of the apoptosis-inducing factor or Bcl-2 inhibitor of transcription by RNA interference can alleviate TAp63gamma-induced apoptosis in esophageal squamous carcinoma EC9706 cells JOURNAL Int J Oncol 35 (2), 359-367 (2009) PUBMED 19578750 REMARK GeneRIF: TAp63gamma could induce apoptosis in human esophageal squamous cancer EC9706 cells, through at least releasing AIF and Bit1 from...","source":"Homo sapiens (human)","symbol":"PTRH2","synonym":"BIT1; CFAP37; CGI-147; IMNEPD; PTH; PTH 2; PTH2","version":"NM_016077.5"},{"aa_position":[],"accession":"NM_001288565","definition":"Homo sapiens transmembrane protein 9 (TMEM9), transcript variant 3, mRNA.","division":"RefSeq","geneid":"252839","gi":"","length":"1994","nt_position":[],"snippet":"Wnt/beta-catenin signaling pathway is involved in the induction of these cytokine expressions. REFERENCE 7 (bases 1 to 1994) AUTHORS Zhang,Y., Ran,Y., Xiong,Y., Zhong,Z.B., Wang,Z.H., Fan,X.L. and Ye,Q.F. TITLE Effects of TMEM9 gene on cell progression in hepatocellular carcinoma by RNA interference JOURNAL Oncol Rep 36 (1), 299-305 (2016) PUBMED 27220462 REMARK GeneRIF: TMEM9 knockdown by RNA interference resulted in G1 arrest. REFERENCE 8 (bases 1 to 1994) AUTHORS Dodeller,F., Gottar,M., Huesken,D., Iourgenko,V. and Cenni,B. TITLE The lysosomal transmembrane protein 9B regulates the activity...","source":"Homo sapiens (human)","symbol":"TMEM9","synonym":"DERM4; TMEM9A","version":"NM_001288565.2"},{"aa_position":[],"accession":"NM_017970","definition":"Homo sapiens NRDE-2, necessary for RNA interference, domain containing (NRDE2), mRNA.","division":"RefSeq","geneid":"55051","gi":"","length":"14008","nt_position":[],"snippet":"LOCUS NM_017970 14008 bp mRNA linear PRI 20-NOV-2025 DEFINITION Homo sapiens NRDE-2, necessary for RNA interference, domain containing (NRDE2), mRNA. ACCESSION NM_017970 VERSION NM_017970.4 KEYWORDS RefSeq; MANE Select. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE COMMENT VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK294958.1, BC008925.2, AW196499.1,...","source":"Homo sapiens (human)","symbol":"NRDE2","synonym":"C14orf102","version":"NM_017970.4"},{"aa_position":[],"accession":"NM_001164470","definition":"Homo sapiens membrane spanning 4-domains A12 (MS4A12), transcript variant 2, mRNA.","division":"RefSeq","geneid":"54860","gi":"","length":"1029","nt_position":[],"snippet":"REFERENCE 4 (bases 1 to 1029) AUTHORS Koslowski,M., Tureci,O., Huber,C. and Sahin,U. TITLE Selective activation of tumor growth-promoting Ca2+ channel MS4A12 in colon cancer by caudal type homeobox transcription factor CDX2 JOURNAL Mol Cancer 8, 77 (2009) PUBMED 19781065 REMARK GeneRIF: RNA interference of CDX1 and CDX2 and chromatin immunoprecipitation in colon cancer cells revealed that MS4A12 transcript and protein expression is essentially dependent on the presence of endogenous CDX2. Publication Status: Online-Only REFERENCE 5 (bases 1 to 1029) AUTHORS Koslowski,M., Sahin,U., Dhaene,K.,...","source":"Homo sapiens (human)","symbol":"MS4A12","synonym":"Ms4a10","version":"NM_001164470.2"},{"aa_position":[],"accession":"NR_109921","definition":"Homo sapiens transmembrane protein 9 (TMEM9), transcript variant 11, non-coding RNA.","division":"RefSeq","geneid":"252839","gi":"","length":"1963","nt_position":[],"snippet":"Wnt/beta-catenin signaling pathway is involved in the induction of these cytokine expressions. REFERENCE 7 (bases 1 to 1963) AUTHORS Zhang,Y., Ran,Y., Xiong,Y., Zhong,Z.B., Wang,Z.H., Fan,X.L. and Ye,Q.F. TITLE Effects of TMEM9 gene on cell progression in hepatocellular carcinoma by RNA interference JOURNAL Oncol Rep 36 (1), 299-305 (2016) PUBMED 27220462 REMARK GeneRIF: TMEM9 knockdown by RNA interference resulted in G1 arrest. REFERENCE 8 (bases 1 to 1963) AUTHORS Dodeller,F., Gottar,M., Huesken,D., Iourgenko,V. and Cenni,B. TITLE The lysosomal transmembrane protein 9B regulates the activity...","source":"Homo sapiens (human)","symbol":"TMEM9","synonym":"DERM4; TMEM9A","version":"NR_109921.2"},{"aa_position":[],"accession":"NM_017716","definition":"Homo sapiens membrane spanning 4-domains A12 (MS4A12), transcript variant 1, mRNA.","division":"RefSeq","geneid":"54860","gi":"","length":"1167","nt_position":[],"snippet":"REFERENCE 4 (bases 1 to 1167) AUTHORS Koslowski,M., Tureci,O., Huber,C. and Sahin,U. TITLE Selective activation of tumor growth-promoting Ca2+ channel MS4A12 in colon cancer by caudal type homeobox transcription factor CDX2 JOURNAL Mol Cancer 8, 77 (2009) PUBMED 19781065 REMARK GeneRIF: RNA interference of CDX1 and CDX2 and chromatin immunoprecipitation in colon cancer cells revealed that MS4A12 transcript and protein expression is essentially dependent on the presence of endogenous CDX2. Publication Status: Online-Only REFERENCE 5 (bases 1 to 1167) AUTHORS Koslowski,M., Sahin,U., Dhaene,K.,...","source":"Homo sapiens (human)","symbol":"MS4A12","synonym":"Ms4a10","version":"NM_017716.3"},{"aa_position":[],"accession":"NM_001365714","definition":"Homo sapiens vesicle transport through interaction with t-SNAREs 1A (VTI1A), transcript variant 11, mRNA.","division":"RefSeq","geneid":"143187","gi":"","length":"975","nt_position":[],"snippet":"of colorectal adenocarcinomas identifies a recurrent VTI1A-TCF7L2 fusion JOURNAL Nat Genet 43 (10), 964-968 (2011) PUBMED 21892161 REMARK GeneRIF: We found a colorectal carcinoma cell line harboring the fusion gene to be dependent on VTI1A-TCF7L2 for anchorage-independent growth using RNA interference-mediated knockdown. Publication Status: Online-Only REFERENCE 6 (bases 1 to 975) AUTHORS Flowerdew,S.E. and Burgoyne,R.D. TITLE A VAMP7/Vti1a SNARE complex distinguishes a non-conventional traffic route to the cell surface used by KChIP1 and Kv4 potassium channels JOURNAL Biochem J...","source":"Homo sapiens (human)","symbol":"VTI1A","synonym":"MMDS3; MVti1; Vti1-rp2; VTI1RP2","version":"NM_001365714.1"},{"aa_position":[],"accession":"NM_001135195","definition":"Homo sapiens solute carrier family 39 member 5 (SLC39A5), transcript variant 2, mRNA.","division":"RefSeq","geneid":"283375","gi":"","length":"1985","nt_position":[],"snippet":"promotes lung adenocarcinoma cell proliferation by activating PI3K/AKT signaling. REFERENCE 5 (bases 1 to 1985) AUTHORS Li Q, Jin J, Liu J, Wang L and He Y. TITLE Knockdown of Zinc Transporter ZIP5 by RNA Interference Inhibits Esophageal Cancer Growth In Vivo JOURNAL Oncol Res 24 (3), 205-214 (2016) PUBMED 27458102 REMARK GeneRIF: we found that downregulation of ZIP5 by RNA interference inhibited esophageal cancer growth in vivo, reduced the expression of COX2, and promoted the expression of E-cadherin. REFERENCE 6 (bases 1 to 1985) AUTHORS Guo H, Jin X, Zhu T, Wang T, Tong P, Tian L, Peng Y,...","source":"Homo sapiens (human)","symbol":"SLC39A5","synonym":"LZT-Hs7; MYP24; ZIP5","version":"NM_001135195.1"},{"aa_position":[],"accession":"NM_173596","definition":"Homo sapiens solute carrier family 39 member 5 (SLC39A5), transcript variant 1, mRNA.","division":"RefSeq","geneid":"283375","gi":"","length":"1980","nt_position":[],"snippet":"promotes lung adenocarcinoma cell proliferation by activating PI3K/AKT signaling. REFERENCE 5 (bases 1 to 1980) AUTHORS Li Q, Jin J, Liu J, Wang L and He Y. TITLE Knockdown of Zinc Transporter ZIP5 by RNA Interference Inhibits Esophageal Cancer Growth In Vivo JOURNAL Oncol Res 24 (3), 205-214 (2016) PUBMED 27458102 REMARK GeneRIF: we found that downregulation of ZIP5 by RNA interference inhibited esophageal cancer growth in vivo, reduced the expression of COX2, and promoted the expression of E-cadherin. REFERENCE 6 (bases 1 to 1980) AUTHORS Guo H, Jin X, Zhu T, Wang T, Tong P, Tian L, Peng Y,...","source":"Homo sapiens (human)","symbol":"SLC39A5","synonym":"LZT-Hs7; MYP24; ZIP5","version":"NM_173596.3"},{"aa_position":[],"accession":"NM_001350905","definition":"Homo sapiens Rho related BTB domain containing 1 (RHOBTB1), transcript variant 6, mRNA.","division":"RefSeq","geneid":"9886","gi":"","length":"4273","nt_position":[],"snippet":"Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains JOURNAL Cell Rep 32 (7), 108050 (2020) PUBMED 32814053 REFERENCE 3 (bases 1 to 4273) AUTHORS Long,M., Kranjc,T., Mysior,M.M. and Simpson,J.C. TITLE RNA Interference Screening Identifies Novel Roles for RhoBTB1 and RhoBTB3 in Membrane Trafficking Events in Mammalian Cells JOURNAL Cells 9 (5), 1089 (2020) PUBMED 32354068 REMARK GeneRIF: RNA Interference Screening Identifies Novel Roles for RhoBTB1 and RhoBTB3 in Membrane Trafficking Events in Mammalian Cells...","source":"Homo sapiens (human)","symbol":"RHOBTB1","synonym":"","version":"NM_001350905.2"},{"aa_position":[],"accession":"NM_001350911","definition":"Homo sapiens Rho related BTB domain containing 1 (RHOBTB1), transcript variant 12, mRNA.","division":"RefSeq","geneid":"9886","gi":"","length":"4330","nt_position":[],"snippet":"Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains JOURNAL Cell Rep 32 (7), 108050 (2020) PUBMED 32814053 REFERENCE 3 (bases 1 to 4330) AUTHORS Long,M., Kranjc,T., Mysior,M.M. and Simpson,J.C. TITLE RNA Interference Screening Identifies Novel Roles for RhoBTB1 and RhoBTB3 in Membrane Trafficking Events in Mammalian Cells JOURNAL Cells 9 (5), 1089 (2020) PUBMED 32354068 REMARK GeneRIF: RNA Interference Screening Identifies Novel Roles for RhoBTB1 and RhoBTB3 in Membrane Trafficking Events in Mammalian Cells...","source":"Homo sapiens (human)","symbol":"RHOBTB1","synonym":"","version":"NM_001350911.2"},{"aa_position":[],"accession":"NM_001350910","definition":"Homo sapiens Rho related BTB domain containing 1 (RHOBTB1), transcript variant 11, mRNA.","division":"RefSeq","geneid":"9886","gi":"","length":"4307","nt_position":[],"snippet":"Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains JOURNAL Cell Rep 32 (7), 108050 (2020) PUBMED 32814053 REFERENCE 3 (bases 1 to 4307) AUTHORS Long,M., Kranjc,T., Mysior,M.M. and Simpson,J.C. TITLE RNA Interference Screening Identifies Novel Roles for RhoBTB1 and RhoBTB3 in Membrane Trafficking Events in Mammalian Cells JOURNAL Cells 9 (5), 1089 (2020) PUBMED 32354068 REMARK GeneRIF: RNA Interference Screening Identifies Novel Roles for RhoBTB1 and RhoBTB3 in Membrane Trafficking Events in Mammalian Cells...","source":"Homo sapiens (human)","symbol":"RHOBTB1","synonym":"","version":"NM_001350910.2"},{"aa_position":[],"accession":"NM_001350904","definition":"Homo sapiens Rho related BTB domain containing 1 (RHOBTB1), transcript variant 5, mRNA.","division":"RefSeq","geneid":"9886","gi":"","length":"4293","nt_position":[],"snippet":"Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains JOURNAL Cell Rep 32 (7), 108050 (2020) PUBMED 32814053 REFERENCE 3 (bases 1 to 4293) AUTHORS Long,M., Kranjc,T., Mysior,M.M. and Simpson,J.C. TITLE RNA Interference Screening Identifies Novel Roles for RhoBTB1 and RhoBTB3 in Membrane Trafficking Events in Mammalian Cells JOURNAL Cells 9 (5), 1089 (2020) PUBMED 32354068 REMARK GeneRIF: RNA Interference Screening Identifies Novel Roles for RhoBTB1 and RhoBTB3 in Membrane Trafficking Events in Mammalian Cells...","source":"Homo sapiens (human)","symbol":"RHOBTB1","synonym":"","version":"NM_001350904.2"},{"aa_position":[],"accession":"NM_001350909","definition":"Homo sapiens Rho related BTB domain containing 1 (RHOBTB1), transcript variant 10, mRNA.","division":"RefSeq","geneid":"9886","gi":"","length":"4350","nt_position":[],"snippet":"Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains JOURNAL Cell Rep 32 (7), 108050 (2020) PUBMED 32814053 REFERENCE 3 (bases 1 to 4350) AUTHORS Long,M., Kranjc,T., Mysior,M.M. and Simpson,J.C. TITLE RNA Interference Screening Identifies Novel Roles for RhoBTB1 and RhoBTB3 in Membrane Trafficking Events in Mammalian Cells JOURNAL Cells 9 (5), 1089 (2020) PUBMED 32354068 REMARK GeneRIF: RNA Interference Screening Identifies Novel Roles for RhoBTB1 and RhoBTB3 in Membrane Trafficking Events in Mammalian Cells...","source":"Homo sapiens (human)","symbol":"RHOBTB1","synonym":"","version":"NM_001350909.2"},{"aa_position":[],"accession":"NM_001350902","definition":"Homo sapiens Rho related BTB domain containing 1 (RHOBTB1), transcript variant 3, mRNA.","division":"RefSeq","geneid":"9886","gi":"","length":"4339","nt_position":[],"snippet":"Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains JOURNAL Cell Rep 32 (7), 108050 (2020) PUBMED 32814053 REFERENCE 3 (bases 1 to 4339) AUTHORS Long,M., Kranjc,T., Mysior,M.M. and Simpson,J.C. TITLE RNA Interference Screening Identifies Novel Roles for RhoBTB1 and RhoBTB3 in Membrane Trafficking Events in Mammalian Cells JOURNAL Cells 9 (5), 1089 (2020) PUBMED 32354068 REMARK GeneRIF: RNA Interference Screening Identifies Novel Roles for RhoBTB1 and RhoBTB3 in Membrane Trafficking Events in Mammalian Cells...","source":"Homo sapiens (human)","symbol":"RHOBTB1","synonym":"","version":"NM_001350902.2"},{"aa_position":[],"accession":"NM_001350908","definition":"Homo sapiens Rho related BTB domain containing 1 (RHOBTB1), transcript variant 9, mRNA.","division":"RefSeq","geneid":"9886","gi":"","length":"4400","nt_position":[],"snippet":"Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains JOURNAL Cell Rep 32 (7), 108050 (2020) PUBMED 32814053 REFERENCE 3 (bases 1 to 4400) AUTHORS Long,M., Kranjc,T., Mysior,M.M. and Simpson,J.C. TITLE RNA Interference Screening Identifies Novel Roles for RhoBTB1 and RhoBTB3 in Membrane Trafficking Events in Mammalian Cells JOURNAL Cells 9 (5), 1089 (2020) PUBMED 32354068 REMARK GeneRIF: RNA Interference Screening Identifies Novel Roles for RhoBTB1 and RhoBTB3 in Membrane Trafficking Events in Mammalian Cells...","source":"Homo sapiens (human)","symbol":"RHOBTB1","synonym":"","version":"NM_001350908.2"},{"aa_position":[],"accession":"NM_001350907","definition":"Homo sapiens Rho related BTB domain containing 1 (RHOBTB1), transcript variant 8, mRNA.","division":"RefSeq","geneid":"9886","gi":"","length":"4396","nt_position":[],"snippet":"Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains JOURNAL Cell Rep 32 (7), 108050 (2020) PUBMED 32814053 REFERENCE 3 (bases 1 to 4396) AUTHORS Long,M., Kranjc,T., Mysior,M.M. and Simpson,J.C. TITLE RNA Interference Screening Identifies Novel Roles for RhoBTB1 and RhoBTB3 in Membrane Trafficking Events in Mammalian Cells JOURNAL Cells 9 (5), 1089 (2020) PUBMED 32354068 REMARK GeneRIF: RNA Interference Screening Identifies Novel Roles for RhoBTB1 and RhoBTB3 in Membrane Trafficking Events in Mammalian Cells...","source":"Homo sapiens (human)","symbol":"RHOBTB1","synonym":"","version":"NM_001350907.2"},{"aa_position":[],"accession":"NM_001350903","definition":"Homo sapiens Rho related BTB domain containing 1 (RHOBTB1), transcript variant 2, mRNA.","division":"RefSeq","geneid":"9886","gi":"","length":"4394","nt_position":[],"snippet":"Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains JOURNAL Cell Rep 32 (7), 108050 (2020) PUBMED 32814053 REFERENCE 3 (bases 1 to 4394) AUTHORS Long,M., Kranjc,T., Mysior,M.M. and Simpson,J.C. TITLE RNA Interference Screening Identifies Novel Roles for RhoBTB1 and RhoBTB3 in Membrane Trafficking Events in Mammalian Cells JOURNAL Cells 9 (5), 1089 (2020) PUBMED 32354068 REMARK GeneRIF: RNA Interference Screening Identifies Novel Roles for RhoBTB1 and RhoBTB3 in Membrane Trafficking Events in Mammalian Cells...","source":"Homo sapiens (human)","symbol":"RHOBTB1","synonym":"","version":"NM_001350903.2"},{"aa_position":[],"accession":"NM_001350906","definition":"Homo sapiens Rho related BTB domain containing 1 (RHOBTB1), transcript variant 7, mRNA.","division":"RefSeq","geneid":"9886","gi":"","length":"4451","nt_position":[],"snippet":"Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains JOURNAL Cell Rep 32 (7), 108050 (2020) PUBMED 32814053 REFERENCE 3 (bases 1 to 4451) AUTHORS Long,M., Kranjc,T., Mysior,M.M. and Simpson,J.C. TITLE RNA Interference Screening Identifies Novel Roles for RhoBTB1 and RhoBTB3 in Membrane Trafficking Events in Mammalian Cells JOURNAL Cells 9 (5), 1089 (2020) PUBMED 32354068 REMARK GeneRIF: RNA Interference Screening Identifies Novel Roles for RhoBTB1 and RhoBTB3 in Membrane Trafficking Events in Mammalian Cells...","source":"Homo sapiens (human)","symbol":"RHOBTB1","synonym":"","version":"NM_001350906.2"},{"aa_position":[],"accession":"NR_130709","definition":"Homo sapiens ADAM metallopeptidase domain 28 (ADAM28), transcript variant 5, non-coding RNA.","division":"RefSeq","geneid":"10863","gi":"","length":"1913","nt_position":[],"snippet":"D. TITLE ADAM28: Another ambivalent protease in cancer JOURNAL Cancer Lett 494, 18-26 (2020) PUBMED 32861707 REMARK GeneRIF: ADAM28: Another ambivalent protease in cancer. Review article REFERENCE 4 (bases 1 to 1913) AUTHORS Zhao Z, Qiu HY, Fu L and Li J. TITLE [Construction of ADAM28 shRNA interference vector and its inhibitory effect on human periodontal ligament stem cells] JOURNAL Shanghai Kou Qiang Yi Xue 29 (5), 476-481 (2020) PUBMED 33543212 REMARK GeneRIF: [Construction of ADAM28 shRNA interference vector and its inhibitory effect on human periodontal ligament stem cells]. REFERENCE...","source":"Homo sapiens (human)","symbol":"ADAM28","synonym":"ADAM 28; eMDC II; eMDCII; MDC-L; MDCL","version":"NR_130709.2"},{"aa_position":[],"accession":"NM_014836","definition":"Homo sapiens Rho related BTB domain containing 1 (RHOBTB1), transcript variant 1, mRNA.","division":"RefSeq","geneid":"9886","gi":"","length":"4411","nt_position":[],"snippet":"Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains JOURNAL Cell Rep 32 (7), 108050 (2020) PUBMED 32814053 REFERENCE 3 (bases 1 to 4411) AUTHORS Long,M., Kranjc,T., Mysior,M.M. and Simpson,J.C. TITLE RNA Interference Screening Identifies Novel Roles for RhoBTB1 and RhoBTB3 in Membrane Trafficking Events in Mammalian Cells JOURNAL Cells 9 (5), 1089 (2020) PUBMED 32354068 REMARK GeneRIF: RNA Interference Screening Identifies Novel Roles for RhoBTB1 and RhoBTB3 in Membrane Trafficking Events in Mammalian Cells...","source":"Homo sapiens (human)","symbol":"RHOBTB1","synonym":"","version":"NM_014836.5"},{"aa_position":[],"accession":"NM_001272007","definition":"Homo sapiens iron-sulfur cluster assembly 2 (ISCA2), transcript variant 2, mRNA; nuclear gene for mitochondrial product.","division":"RefSeq","geneid":"122961","gi":"","length":"2465","nt_position":[],"snippet":"O., Niggemeyer,B., Elsasser,H.P., Muhlenhoff,U. and Lill,R. TITLE The human mitochondrial ISCA1, ISCA2, and IBA57 proteins are required for [4Fe-4S] protein maturation JOURNAL Mol Biol Cell 23 (7), 1157-1166 (2012) PUBMED 22323289 REMARK GeneRIF: ISCA1, ISCA2, and IBA57 were depleted by RNA interference. Depleted cells contained massively swollen and enlarged mitochondria that were virtually devoid of cristae membranes, demonstrating the importance of these proteins for mitochondrial biogenesis. REFERENCE 7 (bases 1 to 2465) AUTHORS Bailey,S.D., Xie,C., Do,R., Montpetit,A., Diaz,R., Mohan,V.,...","source":"Homo sapiens (human)","symbol":"ISCA2","synonym":"c14_5557; HBLD1; ISA2; MMDS4","version":"NM_001272007.2"},{"aa_position":[],"accession":"NM_001322296","definition":"Homo sapiens SID1 transmembrane family member 1 (SIDT1), transcript variant 5, mRNA.","division":"RefSeq","geneid":"54847","gi":"","length":"4647","nt_position":[],"snippet":"derived from AC112128.4, AC055740.17 and AI004220.1. On Jun 2, 2019 this sequence version replaced NM_001322296.1. Summary: The protein encoded by this gene belongs to SID1 family of transmembrane dsRNA-gated channels. Family members transport dsRNA into cells and are required for systemic RNA interference. [provided by RefSeq, May 2017]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-...","source":"Homo sapiens (human)","symbol":"SIDT1","synonym":"SID-1; SID1","version":"NM_001322296.2"},{"aa_position":[],"accession":"NM_001242359","definition":"Homo sapiens Rho related BTB domain containing 1 (RHOBTB1), transcript variant 4, mRNA.","division":"RefSeq","geneid":"9886","gi":"","length":"4483","nt_position":[],"snippet":"Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains JOURNAL Cell Rep 32 (7), 108050 (2020) PUBMED 32814053 REFERENCE 3 (bases 1 to 4483) AUTHORS Long,M., Kranjc,T., Mysior,M.M. and Simpson,J.C. TITLE RNA Interference Screening Identifies Novel Roles for RhoBTB1 and RhoBTB3 in Membrane Trafficking Events in Mammalian Cells JOURNAL Cells 9 (5), 1089 (2020) PUBMED 32354068 REMARK GeneRIF: RNA Interference Screening Identifies Novel Roles for RhoBTB1 and RhoBTB3 in Membrane Trafficking Events in Mammalian Cells...","source":"Homo sapiens (human)","symbol":"RHOBTB1","synonym":"","version":"NM_001242359.2"},{"aa_position":[],"accession":"NM_001322297","definition":"Homo sapiens SID1 transmembrane family member 1 (SIDT1), transcript variant 6, mRNA.","division":"RefSeq","geneid":"54847","gi":"","length":"4711","nt_position":[],"snippet":"derived from AC112128.4, AC055740.17 and AI004220.1. On Jun 2, 2019 this sequence version replaced NM_001322297.1. Summary: The protein encoded by this gene belongs to SID1 family of transmembrane dsRNA-gated channels. Family members transport dsRNA into cells and are required for systemic RNA interference. [provided by RefSeq, May 2017]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-...","source":"Homo sapiens (human)","symbol":"SIDT1","synonym":"SID-1; SID1","version":"NM_001322297.2"},{"aa_position":[],"accession":"NM_001322300","definition":"Homo sapiens SID1 transmembrane family member 1 (SIDT1), transcript variant 9, mRNA.","division":"RefSeq","geneid":"54847","gi":"","length":"4730","nt_position":[],"snippet":"derived from AC112128.4, AC055740.17 and AI004220.1. On Jun 2, 2019 this sequence version replaced NM_001322300.1. Summary: The protein encoded by this gene belongs to SID1 family of transmembrane dsRNA-gated channels. Family members transport dsRNA into cells and are required for systemic RNA interference. [provided by RefSeq, May 2017]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-...","source":"Homo sapiens (human)","symbol":"SIDT1","synonym":"SID-1; SID1","version":"NM_001322300.2"},{"aa_position":[],"accession":"NM_021777","definition":"Homo sapiens ADAM metallopeptidase domain 28 (ADAM28), transcript variant 3, mRNA.","division":"RefSeq","geneid":"10863","gi":"","length":"2106","nt_position":[],"snippet":"TITLE ADAM28: Another ambivalent protease in cancer JOURNAL Cancer Lett 494, 18-26 (2020) PUBMED 32861707 REMARK GeneRIF: ADAM28: Another ambivalent protease in cancer. Review article REFERENCE 4 (bases 1 to 2106) AUTHORS Zhao,Z., Qiu,H.Y., Fu,L. and Li,J. TITLE [Construction of ADAM28 shRNA interference vector and its inhibitory effect on human periodontal ligament stem cells] JOURNAL Shanghai Kou Qiang Yi Xue 29 (5), 476-481 (2020) PUBMED 33543212 REMARK GeneRIF: [Construction of ADAM28 shRNA interference vector and its inhibitory effect on human periodontal ligament stem cells]. REFERENCE...","source":"Homo sapiens (human)","symbol":"ADAM28","synonym":"ADAM 28; eMDC II; eMDCII; MDC-L; MDCL","version":"NM_021777.5"},{"aa_position":[],"accession":"NM_001322295","definition":"Homo sapiens SID1 transmembrane family member 1 (SIDT1), transcript variant 4, mRNA.","division":"RefSeq","geneid":"54847","gi":"","length":"4749","nt_position":[],"snippet":"derived from AC112128.4, AC055740.17 and AI004220.1. On Jun 2, 2019 this sequence version replaced NM_001322295.1. Summary: The protein encoded by this gene belongs to SID1 family of transmembrane dsRNA-gated channels. Family members transport dsRNA into cells and are required for systemic RNA interference. [provided by RefSeq, May 2017]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-...","source":"Homo sapiens (human)","symbol":"SIDT1","synonym":"SID-1; SID1","version":"NM_001322295.2"},{"aa_position":[],"accession":"NM_001322298","definition":"Homo sapiens SID1 transmembrane family member 1 (SIDT1), transcript variant 7, mRNA.","division":"RefSeq","geneid":"54847","gi":"","length":"4810","nt_position":[],"snippet":"derived from AC112128.4, AC055740.17 and AI004220.1. On Jun 2, 2019 this sequence version replaced NM_001322298.1. Summary: The protein encoded by this gene belongs to SID1 family of transmembrane dsRNA-gated channels. Family members transport dsRNA into cells and are required for systemic RNA interference. [provided by RefSeq, May 2017]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-...","source":"Homo sapiens (human)","symbol":"SIDT1","synonym":"SID-1; SID1","version":"NM_001322298.2"},{"aa_position":[],"accession":"NM_001322299","definition":"Homo sapiens SID1 transmembrane family member 1 (SIDT1), transcript variant 8, mRNA.","division":"RefSeq","geneid":"54847","gi":"","length":"4837","nt_position":[],"snippet":"AC112128.4, BC143778.1, AC055740.17 and AI004220.1. On Jun 2, 2019 this sequence version replaced NM_001322299.1. Summary: The protein encoded by this gene belongs to SID1 family of transmembrane dsRNA-gated channels. Family members transport dsRNA into cells and are required for systemic RNA interference. [provided by RefSeq, May 2017]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-...","source":"Homo sapiens (human)","symbol":"SIDT1","synonym":"SID-1; SID1","version":"NM_001322299.2"},{"aa_position":[],"accession":"NM_017699","definition":"Homo sapiens SID1 transmembrane family member 1 (SIDT1), transcript variant 2, mRNA.","division":"RefSeq","geneid":"54847","gi":"","length":"4818","nt_position":[],"snippet":"is a reference standard in the RefSeqGene project. On Jun 2, 2019 this sequence version replaced NM_017699.2. Summary: The protein encoded by this gene belongs to SID1 family of transmembrane dsRNA-gated channels. Family members transport dsRNA into cells and are required for systemic RNA interference. [provided by RefSeq, May 2017]. Transcript Variant: This variant (2) encodes isoform 2. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST264852.9/...","source":"Homo sapiens (human)","symbol":"SIDT1","synonym":"SID-1; SID1","version":"NM_017699.3"},{"aa_position":[],"accession":"NM_001308350","definition":"Homo sapiens SID1 transmembrane family member 1 (SIDT1), transcript variant 1, mRNA.","division":"RefSeq","geneid":"54847","gi":"","length":"4833","nt_position":[],"snippet":"AC112128.4, BC117222.1, AC055740.17 and AI004220.1. On Aug 13, 2020 this sequence version replaced NM_001308350.1. Summary: The protein encoded by this gene belongs to SID1 family of transmembrane dsRNA-gated channels. Family members transport dsRNA into cells and are required for systemic RNA interference. [provided by RefSeq, May 2017]. Transcript Variant: This variant (1) encodes isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript...","source":"Homo sapiens (human)","symbol":"SIDT1","synonym":"SID-1; SID1","version":"NM_001308350.2"},{"aa_position":[],"accession":"NM_003168","definition":"Homo sapiens SPT4 homolog, DSIF elongation factor subunit (SUPT4H1), transcript variant 1, mRNA.","division":"RefSeq","geneid":"6827","gi":"","length":"1488","nt_position":[],"snippet":"Status: Online-Only REFERENCE 4 (bases 1 to 1488) AUTHORS Naguib,A., Sandmann,T., Yi,F., Watts,R.J., Lewcock,J.W. and Dowdle,W.E. TITLE SUPT4H1 Depletion Leads to a Global Reduction in RNA JOURNAL Cell Rep 26 (1), 45-53 (2019) PUBMED 30605685 REMARK GeneRIF: Authors depleted SUPT4H1 by RNA interference to inhibit the function of the SUPT4H1/SUPT5H transcription elongation complex. Depletion of SUPT4H1 leads to a global reduction in all cellular RNA. REFERENCE 5 (bases 1 to 1488) AUTHORS Kramer,N.J., Carlomagno,Y., Zhang,Y.J., Almeida,S., Cook,C.N., Gendron,T.F., Prudencio,M., Van Blitterswijk,...","source":"Homo sapiens (human)","symbol":"SUPT4H1","synonym":"SPT4; SPT4H; Supt4a; SUPT4H","version":"NM_003168.3"},{"aa_position":[],"accession":"NM_001322294","definition":"Homo sapiens SID1 transmembrane family member 1 (SIDT1), transcript variant 3, mRNA.","division":"RefSeq","geneid":"54847","gi":"","length":"4836","nt_position":[],"snippet":"derived from AC112128.4, AC055740.17 and AI004220.1. On Jun 2, 2019 this sequence version replaced NM_001322294.1. Summary: The protein encoded by this gene belongs to SID1 family of transmembrane dsRNA-gated channels. Family members transport dsRNA into cells and are required for systemic RNA interference. [provided by RefSeq, May 2017]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-...","source":"Homo sapiens (human)","symbol":"SIDT1","synonym":"SID-1; SID1","version":"NM_001322294.2"},{"aa_position":[],"accession":"NR_136285","definition":"Homo sapiens SID1 transmembrane family member 1 (SIDT1), transcript variant 15, non-coding RNA.","division":"RefSeq","geneid":"54847","gi":"","length":"4392","nt_position":[],"snippet":"derived from AC112128.4, AC055740.17 and AI004220.1. On Jul 12, 2019 this sequence version replaced NR_136285.1. Summary: The protein encoded by this gene belongs to SID1 family of transmembrane dsRNA-gated channels. Family members transport dsRNA into cells and are required for systemic RNA interference. [provided by RefSeq, May 2017]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-...","source":"Homo sapiens (human)","symbol":"SIDT1","synonym":"SID-1; SID1","version":"NR_136285.2"},{"aa_position":[],"accession":"NM_015169","definition":"Homo sapiens regulator of ribosome synthesis 1 (RRS1), mRNA.","division":"RefSeq","geneid":"23212","gi":"","length":"1720","nt_position":[],"snippet":"PUBMED 33961781 REFERENCE 6 (bases 1 to 1720) AUTHORS Gambe,A.E., Matsunaga,S., Takata,H., Ono-Maniwa,R., Baba,A., Uchiyama,S. and Fukui,K. TITLE A nucleolar protein RRS1 contributes to chromosome congression JOURNAL FEBS Lett 583 (12), 1951-1956 (2009) PUBMED 19465021 REMARK GeneRIF: RNA interference experiments revealed that RRS1-depleted cells show abnormalities in chromosome alignment and spindle organization, which result in mitotic delay. REFERENCE 7 (bases 1 to 1720) AUTHORS Andersen,J.S., Lam,Y.W., Leung,A.K., Ong,S.E., Lyon,C.E., Lamond,A.I. and Mann,M. TITLE Nucleolar proteome...","source":"Homo sapiens (human)","symbol":"RRS1","synonym":"","version":"NM_015169.4"},{"aa_position":[],"accession":"NM_194279","definition":"Homo sapiens iron-sulfur cluster assembly 2 (ISCA2), transcript variant 1, mRNA; nuclear gene for mitochondrial product.","division":"RefSeq","geneid":"122961","gi":"","length":"2581","nt_position":[],"snippet":"O., Niggemeyer,B., Elsasser,H.P., Muhlenhoff,U. and Lill,R. TITLE The human mitochondrial ISCA1, ISCA2, and IBA57 proteins are required for [4Fe-4S] protein maturation JOURNAL Mol Biol Cell 23 (7), 1157-1166 (2012) PUBMED 22323289 REMARK GeneRIF: ISCA1, ISCA2, and IBA57 were depleted by RNA interference. Depleted cells contained massively swollen and enlarged mitochondria that were virtually devoid of cristae membranes, demonstrating the importance of these proteins for mitochondrial biogenesis. REFERENCE 7 (bases 1 to 2581) AUTHORS Bailey,S.D., Xie,C., Do,R., Montpetit,A., Diaz,R., Mohan,V.,...","source":"Homo sapiens (human)","symbol":"ISCA2","synonym":"c14_5557; HBLD1; ISA2; MMDS4","version":"NM_194279.4"},{"aa_position":[],"accession":"NM_001297550","definition":"Homo sapiens apelin receptor early endogenous ligand (APELA), mRNA.","division":"RefSeq","geneid":"100506013","gi":"","length":"2432","nt_position":[],"snippet":"definitive endoderm JOURNAL Gene Expr Patterns 10 (2-3), 127-134 (2010) PUBMED 20153842 REFERENCE 9 (bases 1 to 2432) AUTHORS Ahn,S., Nelson,C.D., Garrison,T.R., Miller,W.E. and Lefkowitz,R.J. TITLE Desensitization, internalization, and signaling functions of beta-arrestins demonstrated by RNA interference JOURNAL Proc Natl Acad Sci U S A 100 (4), 1740-1744 (2003) PUBMED 12582207 REFERENCE 10 (bases 1 to 2432) AUTHORS Cheng,Z.J., Zhao,J., Sun,Y., Hu,W., Wu,Y.L., Cen,B., Wu,G.X. and Pei,G. TITLE beta-arrestin differentially regulates the chemokine receptor CXCR4-mediated signaling and receptor...","source":"Homo sapiens (human)","symbol":"APELA","synonym":"ELA; Ende; tdl","version":"NM_001297550.2"},{"aa_position":[],"accession":"NR_136284","definition":"Homo sapiens SID1 transmembrane family member 1 (SIDT1), transcript variant 14, non-coding RNA.","division":"RefSeq","geneid":"54847","gi":"","length":"4529","nt_position":[],"snippet":"derived from AC112128.4, AC055740.17 and AI004220.1. On Jul 12, 2019 this sequence version replaced NR_136284.1. Summary: The protein encoded by this gene belongs to SID1 family of transmembrane dsRNA-gated channels. Family members transport dsRNA into cells and are required for systemic RNA interference. [provided by RefSeq, May 2017]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-...","source":"Homo sapiens (human)","symbol":"SIDT1","synonym":"SID-1; SID1","version":"NR_136284.2"},{"aa_position":[],"accession":"NR_136283","definition":"Homo sapiens SID1 transmembrane family member 1 (SIDT1), transcript variant 13, non-coding RNA.","division":"RefSeq","geneid":"54847","gi":"","length":"4622","nt_position":[],"snippet":"derived from AC112128.4, AC055740.17 and AI004220.1. On Jul 11, 2019 this sequence version replaced NR_136283.1. Summary: The protein encoded by this gene belongs to SID1 family of transmembrane dsRNA-gated channels. Family members transport dsRNA into cells and are required for systemic RNA interference. [provided by RefSeq, May 2017]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-...","source":"Homo sapiens (human)","symbol":"SIDT1","synonym":"SID-1; SID1","version":"NR_136283.2"},{"aa_position":[],"accession":"NR_136282","definition":"Homo sapiens SID1 transmembrane family member 1 (SIDT1), transcript variant 12, non-coding RNA.","division":"RefSeq","geneid":"54847","gi":"","length":"4759","nt_position":[],"snippet":"AC112128.4, BC143776.1, AC055740.17 and AI004220.1. On Jul 11, 2019 this sequence version replaced NR_136282.1. Summary: The protein encoded by this gene belongs to SID1 family of transmembrane dsRNA-gated channels. Family members transport dsRNA into cells and are required for systemic RNA interference. [provided by RefSeq, May 2017]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-...","source":"Homo sapiens (human)","symbol":"SIDT1","synonym":"SID-1; SID1","version":"NR_136282.2"},{"aa_position":[],"accession":"NR_136281","definition":"Homo sapiens SID1 transmembrane family member 1 (SIDT1), transcript variant 11, non-coding RNA.","division":"RefSeq","geneid":"54847","gi":"","length":"4778","nt_position":[],"snippet":"derived from AC112128.4, AC055740.17 and AI004220.1. On Jul 11, 2019 this sequence version replaced NR_136281.1. Summary: The protein encoded by this gene belongs to SID1 family of transmembrane dsRNA-gated channels. Family members transport dsRNA into cells and are required for systemic RNA interference. [provided by RefSeq, May 2017]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-...","source":"Homo sapiens (human)","symbol":"SIDT1","synonym":"SID-1; SID1","version":"NR_136281.2"},{"aa_position":[],"accession":"NR_136280","definition":"Homo sapiens SID1 transmembrane family member 1 (SIDT1), transcript variant 10, non-coding RNA.","division":"RefSeq","geneid":"54847","gi":"","length":"4839","nt_position":[],"snippet":"derived from AC112128.4, AC055740.17 and AI004220.1. On Jul 11, 2019 this sequence version replaced NR_136280.1. Summary: The protein encoded by this gene belongs to SID1 family of transmembrane dsRNA-gated channels. Family members transport dsRNA into cells and are required for systemic RNA interference. [provided by RefSeq, May 2017]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-...","source":"Homo sapiens (human)","symbol":"SIDT1","synonym":"SID-1; SID1","version":"NR_136280.2"},{"aa_position":[],"accession":"NR_073470","definition":"Homo sapiens SPT4 homolog, DSIF elongation factor subunit (SUPT4H1), transcript variant 2, non-coding RNA.","division":"RefSeq","geneid":"6827","gi":"","length":"1490","nt_position":[],"snippet":"Status: Online-Only REFERENCE 4 (bases 1 to 1490) AUTHORS Naguib,A., Sandmann,T., Yi,F., Watts,R.J., Lewcock,J.W. and Dowdle,W.E. TITLE SUPT4H1 Depletion Leads to a Global Reduction in RNA JOURNAL Cell Rep 26 (1), 45-53 (2019) PUBMED 30605685 REMARK GeneRIF: Authors depleted SUPT4H1 by RNA interference to inhibit the function of the SUPT4H1/SUPT5H transcription elongation complex. Depletion of SUPT4H1 leads to a global reduction in all cellular RNA. REFERENCE 5 (bases 1 to 1490) AUTHORS Kramer,N.J., Carlomagno,Y., Zhang,Y.J., Almeida,S., Cook,C.N., Gendron,T.F., Prudencio,M., Van Blitterswijk,...","source":"Homo sapiens (human)","symbol":"SUPT4H1","synonym":"SPT4; SPT4H; Supt4a; SUPT4H","version":"NR_073470.2"},{"aa_position":[],"accession":"NM_007176","definition":"Homo sapiens ergosterol biosynthesis 28 homolog (ERG28), mRNA.","division":"RefSeq","geneid":"11161","gi":"","length":"2320","nt_position":[],"snippet":"involved in neuronal ceroid lipofuscinosis JOURNAL Biochim Biophys Acta 1833 (3), 529-540 (2013) PUBMED 23142642 REFERENCE 5 (bases 1 to 2320) AUTHORS Lee,C.N., Heidbrink,J.L., McKinnon,K., Bushman,V., Olsen,H., FitzHugh,W., Li,A., Van Orden,K., He,T., Ruben,S.M. and Moore,P.A. TITLE RNA interference characterization of proteins discovered by proteomic analysis of pancreatic cancer reveals function in cell growth and survival JOURNAL Pancreas 41 (1), 84-94 (2012) PUBMED 21934552 REMARK GeneRIF: Data indicate that integrin beta6, CD46, tissue factor, and chromosome 14 open reading frame 1...","source":"Homo sapiens (human)","symbol":"ERG28","synonym":"C14orf1; NET51","version":"NM_007176.4"},{"aa_position":[],"accession":"NM_017629","definition":"Homo sapiens argonaute RISC component 4 (AGO4), transcript variant 1, mRNA.","division":"RefSeq","geneid":"192670","gi":"","length":"7272","nt_position":[],"snippet":"The reference sequence was derived from AL354864.16, AB046787.1, AL359186.15 and CA419947.1. On Nov 22, 2018 this sequence version replaced NM_017629.3. Summary: This gene encodes a member of the Argonaute family of proteins which contain PAZ and PIWI domains and play an integral role in RNA interference and short-interfering-RNA-mediated gene silencing. This gene is located on chromosome 1 in a cluster of related family members. [provided by RefSeq, Mar 2017]. Sequence Note: Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent...","source":"Homo sapiens (human)","symbol":"AGO4","synonym":"EIF2C4","version":"NM_017629.4"},{"aa_position":[],"accession":"XM_011539006","definition":"PREDICTED: Homo sapiens piwi like RNA-mediated gene silencing 1 (PIWIL1), transcript variant X7, mRNA.","division":"RefSeq","geneid":"9271","gi":"","length":"2697","nt_position":[],"snippet":"misc_feature <213..317 /gene=\"PIWIL1\" /gene_synonym=\"CT80.1; HIWI; MIWI; PIWI\" /note=\"PAZ domain, named PAZ after the proteins Piwi Argonaut and Zwille. PAZ is found in two families of proteins that are essential components of RNA-mediated gene-silencing pathways, including RNA interference, the piwi and Dicer families. PAZ functions as a...; Region: PAZ; cl00301\" /db_xref=\"CDD:469713\" misc_feature 273..1604 /gene=\"PIWIL1\" /gene_synonym=\"CT80.1; HIWI; MIWI; PIWI\" /note=\"PIWI domain, Piwi-like subfamily found in eukaryotes. This domain is found in Piwi and closely related proteins, where it is...","source":"Homo sapiens (human)","symbol":"PIWIL1","synonym":"CT80.1; HIWI; MIWI; PIWI","version":"XM_011539006.4"},{"aa_position":[],"accession":"NM_001166131","definition":"Homo sapiens essential meiotic structure-specific endonuclease 1 (EME1), transcript variant 1, mRNA.","division":"RefSeq","geneid":"146956","gi":"","length":"2369","nt_position":[],"snippet":"PUBMED 16456034 REMARK GeneRIF: EME-1 deficiency affects cell cycle progression and promotes DNA rereplication. Publication Status: Online-Only REFERENCE 7 (bases 1 to 2369) AUTHORS Blais,V., Gao,H., Elwell,C.A., Boddy,M.N., Gaillard,P.H.L., Russell,P. and McGowan,C.H. TITLE RNA interference inhibition of Mus81 reduces mitotic recombination in human cells JOURNAL Mol Biol Cell 15 (2), 552-562 (2004) PUBMED 14617801 REFERENCE 8 (bases 1 to 2369) AUTHORS Abraham,J., Lemmers,B., Hande,M.P., Moynahan,M.E., Chahwan,C., Ciccia,A., Essers,J., Hanada,K., Chahwan,R., Khaw,A.K., McPherson,P.,...","source":"Homo sapiens (human)","symbol":"EME1","synonym":"MMS4L; SLX2A","version":"NM_001166131.2"},{"aa_position":[],"accession":"NM_152463","definition":"Homo sapiens essential meiotic structure-specific endonuclease 1 (EME1), transcript variant 2, mRNA.","division":"RefSeq","geneid":"146956","gi":"","length":"2330","nt_position":[],"snippet":"PUBMED 16456034 REMARK GeneRIF: EME-1 deficiency affects cell cycle progression and promotes DNA rereplication. Publication Status: Online-Only REFERENCE 7 (bases 1 to 2330) AUTHORS Blais,V., Gao,H., Elwell,C.A., Boddy,M.N., Gaillard,P.H.L., Russell,P. and McGowan,C.H. TITLE RNA interference inhibition of Mus81 reduces mitotic recombination in human cells JOURNAL Mol Biol Cell 15 (2), 552-562 (2004) PUBMED 14617801 REFERENCE 8 (bases 1 to 2330) AUTHORS Abraham,J., Lemmers,B., Hande,M.P., Moynahan,M.E., Chahwan,C., Ciccia,A., Essers,J., Hanada,K., Chahwan,R., Khaw,A.K., McPherson,P.,...","source":"Homo sapiens (human)","symbol":"EME1","synonym":"MMS4L; SLX2A","version":"NM_152463.4"},{"aa_position":[],"accession":"NM_001304508","definition":"Homo sapiens zinc finger and BTB domain containing 25 (ZBTB25), transcript variant 3, mRNA.","division":"RefSeq","geneid":"7597","gi":"","length":"1456","nt_position":[],"snippet":"differentiation, and lineage-specific transcription factors including ZBTB25 as a novel NF-AT repressor JOURNAL Blood 115 (26), 5376-5384 (2010) PUBMED 20410506 REMARK GeneRIF: ZBTB25 functions as a negative regulator of nuclear factor of activated T cells (NF-AT) activation, such that RNA interference mediated knockdown resulted in enhanced activation of target genes. REFERENCE 8 (bases 1 to 1456) AUTHORS Ravasi,T., Suzuki,H., Cannistraci,C.V., Katayama,S., Bajic,V.B., Tan,K., Akalin,A., Schmeier,S., Kanamori-Katayama,M., Bertin,N., Carninci,P., Daub,C.O., Forrest,A.R., Gough,J., Grimmond,S...","source":"Homo sapiens (human)","symbol":"ZBTB25","synonym":"C14orf51; KUP; ZNF46","version":"NM_001304508.1"},{"aa_position":[],"accession":"NM_001170640","definition":"Homo sapiens cyclin dependent kinase 20 (CDK20), transcript variant 5, mRNA.","division":"RefSeq","geneid":"23552","gi":"","length":"1962","nt_position":[],"snippet":"Shokat,K.M. and Fisher,R.P. TITLE The cyclin-dependent kinase (CDK) family member PNQALRE/CCRK supports cell proliferation but has no intrinsic CDK-activating kinase (CAK) activity JOURNAL Cell Cycle 5 (5), 546-554 (2006) PUBMED 16552187 REMARK GeneRIF: Depletion of PNQALRE by >80% due to RNA interference (RNAi) impairs cell proliferation, but fails to arrest the cell cycle at a discrete point. REFERENCE 10 (bases 1 to 1962) AUTHORS Liu,Y., Wu,C. and Galaktionov,K. TITLE p42, a novel cyclin-dependent kinase-activating kinase in mammalian cells JOURNAL J Biol Chem 279 (6), 4507-4514 (2004)...","source":"Homo sapiens (human)","symbol":"CDK20","synonym":"CCRK; CDCH; P42; PNQALRE","version":"NM_001170640.2"},{"aa_position":[],"accession":"NR_111966","definition":"Homo sapiens spalt like transcription factor 2 (SALL2), transcript variant 4, non-coding RNA.","division":"RefSeq","geneid":"6297","gi":"","length":"1756","nt_position":[],"snippet":"function. REFERENCE 3 (bases 1 to 1756) AUTHORS Miao F, Zhang X, Cao Y, Wang Y and Zhang X. TITLE Effect of siRNA-silencing of SALL2 gene on growth, migration and invasion of human ovarian carcinoma A2780 cells JOURNAL BMC Cancer 17 (1), 838 (2017) PUBMED 29228922 REMARK GeneRIF: Using RNA interference, the role of Spalt-like gene-2 (SALL2) was investigated in human ovarian carcinoma (OC) A2780 cells. Found downregulation of SALL2 promoted growth of the OC cell line. Publication Status: Online-Only REFERENCE 4 (bases 1 to 1756) AUTHORS Hermosilla VE, Hepp MI, Escobar D, Farkas C, Riffo EN,...","source":"Homo sapiens (human)","symbol":"SALL2","synonym":"COLB; HSAL2; p150(Sal2); Sal-2; ZNF795","version":"NR_111966.2"},{"aa_position":[],"accession":"NM_001077242","definition":"Homo sapiens DEP domain containing 7 (DEPDC7), transcript variant 1, mRNA.","division":"RefSeq","geneid":"91614","gi":"","length":"1741","nt_position":[],"snippet":"PUBMED 29344171 REFERENCE 2 (bases 1 to 1741) AUTHORS Liao,Z., Wang,X., Lin,D. and Zou,Q. TITLE Construction and Identification of the RNAi Recombinant Lentiviral Vector Targeting Human DEPDC7 Gene JOURNAL Interdiscip Sci 9 (3), 350-356 (2017) PUBMED 27016254 REMARK GeneRIF: RNA interference (RNAi) recombinant lentiviral vector particle targeting DEPDC7 was constructed in order to knockdown its gene expression in human hepatocellular carcinoma cell line HepG2. REFERENCE 3 (bases 1 to 1741) AUTHORS Cordova-Palomera,A., Fatjo-Vilas,M., Palma-Gudiel,H., Blasco-Fontecilla,H., Kebir,O. and Fananas,...","source":"Homo sapiens (human)","symbol":"DEPDC7","synonym":"dJ85M6.4; TR2","version":"NM_001077242.2"},{"aa_position":[],"accession":"NM_001318008","definition":"Homo sapiens TLC domain containing 3A (TLCD3A), transcript variant 4, mRNA.","division":"RefSeq","geneid":"79850","gi":"","length":"1926","nt_position":[],"snippet":"GeneRIF: The researchers found evidence that CT120 may be a key factor in tumor progression and that down-regulation of CT120 may be an effective treatment for lung neoplasms. REFERENCE 3 (bases 1 to 1926) AUTHORS Pan,D., Wei,L., Yao,M., Wan,D. and Gu,J. TITLE Down-regulation of CT120A by RNA interference suppresses lung cancer cells growth and sensitizes to ultraviolet-induced apoptosis JOURNAL Cancer Lett 235 (1), 26-33 (2006) PUBMED 15927361 REFERENCE 4 (bases 1 to 1926) AUTHORS Pan,D.N., Li,J.J., Wei,L., Yao,M., Wan,D.F. and Gu,J.R. TITLE Inhibitory effect of CT120B, an alternative splice...","source":"Homo sapiens (human)","symbol":"TLCD3A","synonym":"CT120; FAM57A","version":"NM_001318008.2"},{"aa_position":[],"accession":"NM_001323602","definition":"Homo sapiens taspase 1 (TASP1), transcript variant 2, mRNA.","division":"RefSeq","geneid":"55617","gi":"","length":"1949","nt_position":[],"snippet":"J., Mitsiou,D.J., Hoiby,T., Veenstra,G.J., Korsmeyer,S.J. and Stunnenberg,H.G. TITLE Uncleaved TFIIA is a substrate for taspase 1 and active in transcription JOURNAL Mol Cell Biol 26 (7), 2728-2735 (2006) PUBMED 16537915 REMARK GeneRIF: Transfected taspase 1 enhances cleavage of TFIIA, and RNA interference knockdown of endogenous taspase 1 diminishes cleavage of TFIIA in vivo. REFERENCE 7 (bases 1 to 1949) AUTHORS Khan,J.A., Dunn,B.M. and Tong,L. TITLE Crystal structure of human Taspase1, a crucial protease regulating the function of MLL JOURNAL Structure 13 (10), 1443-1452 (2005) PUBMED...","source":"Homo sapiens (human)","symbol":"TASP1","synonym":"C20orf13; dJ585I14.2; SULEHS","version":"NM_001323602.2"},{"aa_position":[],"accession":"NM_173546","definition":"Homo sapiens kelch domain containing 8B (KLHDC8B), mRNA.","division":"RefSeq","geneid":"200942","gi":"","length":"1972","nt_position":[],"snippet":"Goldin,L.R. and Horwitz,M.S. TITLE Mutations in a gene encoding a midbody kelch protein in familial and sporadic classical Hodgkin lymphoma lead to binucleated cells JOURNAL Proc Natl Acad Sci U S A 106 (35), 14920-14925 (2009) PUBMED 19706467 REMARK GeneRIF: Depletion of KLHDC8B through RNA interference leads to an increase in binucleated cells, implicating its reduced expression in the formation of classical Hodgkin lymphoma's signature Reed-Sternberg cell. REFERENCE 6 (bases 1 to 1972) AUTHORS Wan,D., Gong,Y., Qin,W., Zhang,P., Li,J., Wei,L., Zhou,X., Li,H., Qiu,X., Zhong,F., He,L., Yu,J.,...","source":"Homo sapiens (human)","symbol":"KLHDC8B","synonym":"CHL","version":"NM_173546.3"},{"aa_position":[],"accession":"NM_001170639","definition":"Homo sapiens cyclin dependent kinase 20 (CDK20), transcript variant 4, mRNA.","division":"RefSeq","geneid":"23552","gi":"","length":"2058","nt_position":[],"snippet":"Shokat,K.M. and Fisher,R.P. TITLE The cyclin-dependent kinase (CDK) family member PNQALRE/CCRK supports cell proliferation but has no intrinsic CDK-activating kinase (CAK) activity JOURNAL Cell Cycle 5 (5), 546-554 (2006) PUBMED 16552187 REMARK GeneRIF: Depletion of PNQALRE by >80% due to RNA interference (RNAi) impairs cell proliferation, but fails to arrest the cell cycle at a discrete point. REFERENCE 10 (bases 1 to 2058) AUTHORS Liu,Y., Wu,C. and Galaktionov,K. TITLE p42, a novel cyclin-dependent kinase-activating kinase in mammalian cells JOURNAL J Biol Chem 279 (6), 4507-4514 (2004)...","source":"Homo sapiens (human)","symbol":"CDK20","synonym":"CCRK; CDCH; P42; PNQALRE","version":"NM_001170639.2"},{"aa_position":[],"accession":"NR_111967","definition":"Homo sapiens spalt like transcription factor 2 (SALL2), transcript variant 5, non-coding RNA.","division":"RefSeq","geneid":"6297","gi":"","length":"1769","nt_position":[],"snippet":"function. REFERENCE 3 (bases 1 to 1769) AUTHORS Miao F, Zhang X, Cao Y, Wang Y and Zhang X. TITLE Effect of siRNA-silencing of SALL2 gene on growth, migration and invasion of human ovarian carcinoma A2780 cells JOURNAL BMC Cancer 17 (1), 838 (2017) PUBMED 29228922 REMARK GeneRIF: Using RNA interference, the role of Spalt-like gene-2 (SALL2) was investigated in human ovarian carcinoma (OC) A2780 cells. Found downregulation of SALL2 promoted growth of the OC cell line. Publication Status: Online-Only REFERENCE 4 (bases 1 to 1769) AUTHORS Hermosilla VE, Hepp MI, Escobar D, Farkas C, Riffo EN,...","source":"Homo sapiens (human)","symbol":"SALL2","synonym":"COLB; HSAL2; p150(Sal2); Sal-2; ZNF795","version":"NR_111967.2"},{"aa_position":[],"accession":"NM_003217","definition":"Homo sapiens transmembrane BAX inhibitor motif containing 6 (TMBIM6), transcript variant 1, mRNA.","division":"RefSeq","geneid":"7009","gi":"","length":"2837","nt_position":[],"snippet":"human interactome JOURNAL Cell 184 (11), 3022-3040 (2021) PUBMED 33961781 REFERENCE 6 (bases 1 to 2837) AUTHORS Grzmil,M., Thelen,P., Hemmerlein,B., Schweyer,S., Voigt,S., Mury,D. and Burfeind,P. TITLE Bax inhibitor-1 is overexpressed in prostate cancer and its specific down-regulation by RNA interference leads to cell death in human prostate carcinoma cells JOURNAL Am J Pathol 163 (2), 543-552 (2003) PUBMED 12875974 REMARK GeneRIF: Results indicate that the human Bax inhibitor-1 gene may serve as a prostate cancer expression marker based on its overexpression in prostate carcinoma and...","source":"Homo sapiens (human)","symbol":"TMBIM6","synonym":"BAXI1; BI-1; TEGT","version":"NM_003217.3"},{"aa_position":[],"accession":"NM_012119","definition":"Homo sapiens cyclin dependent kinase 20 (CDK20), transcript variant 2, mRNA.","division":"RefSeq","geneid":"23552","gi":"","length":"2086","nt_position":[],"snippet":"Shokat,K.M. and Fisher,R.P. TITLE The cyclin-dependent kinase (CDK) family member PNQALRE/CCRK supports cell proliferation but has no intrinsic CDK-activating kinase (CAK) activity JOURNAL Cell Cycle 5 (5), 546-554 (2006) PUBMED 16552187 REMARK GeneRIF: Depletion of PNQALRE by >80% due to RNA interference (RNAi) impairs cell proliferation, but fails to arrest the cell cycle at a discrete point. REFERENCE 10 (bases 1 to 2086) AUTHORS Liu,Y., Wu,C. and Galaktionov,K. TITLE p42, a novel cyclin-dependent kinase-activating kinase in mammalian cells JOURNAL J Biol Chem 279 (6), 4507-4514 (2004)...","source":"Homo sapiens (human)","symbol":"CDK20","synonym":"CCRK; CDCH; P42; PNQALRE","version":"NM_012119.5"},{"aa_position":[],"accession":"NM_020141","definition":"Homo sapiens transmembrane protein 167B (TMEM167B), transcript variant 1, mRNA.","division":"RefSeq","geneid":"56900","gi":"","length":"2769","nt_position":[],"snippet":"map of the human binary protein interactome JOURNAL Nature 580 (7803), 402-408 (2020) PUBMED 32296183 REFERENCE 2 (bases 1 to 2769) AUTHORS Wendler,F., Gillingham,A.K., Sinka,R., Rosa-Ferreira,C., Gordon,D.E., Franch-Marro,X., Peden,A.A., Vincent,J.P. and Munro,S. TITLE A genome-wide RNA interference screen identifies two novel components of the metazoan secretory pathway JOURNAL EMBO J 29 (2), 304-314 (2010) PUBMED 19942856 REFERENCE 3 (bases 1 to 2769) AUTHORS Hu,R.M., Han,Z.G., Song,H.D., Peng,Y.D., Huang,Q.H., Ren,S.X., Gu,Y.J., Huang,C.H., Li,Y.B., Jiang,C.L., Fu,G., Zhang,Q.H., Gu,B.W.,...","source":"Homo sapiens (human)","symbol":"TMEM167B","synonym":"AD-020; C1orf119","version":"NM_020141.4"},{"aa_position":[],"accession":"NM_001318007","definition":"Homo sapiens TLC domain containing 3A (TLCD3A), transcript variant 3, mRNA.","division":"RefSeq","geneid":"79850","gi":"","length":"2022","nt_position":[],"snippet":"GeneRIF: The researchers found evidence that CT120 may be a key factor in tumor progression and that down-regulation of CT120 may be an effective treatment for lung neoplasms. REFERENCE 3 (bases 1 to 2022) AUTHORS Pan,D., Wei,L., Yao,M., Wan,D. and Gu,J. TITLE Down-regulation of CT120A by RNA interference suppresses lung cancer cells growth and sensitizes to ultraviolet-induced apoptosis JOURNAL Cancer Lett 235 (1), 26-33 (2006) PUBMED 15927361 REFERENCE 4 (bases 1 to 2022) AUTHORS Pan,D.N., Li,J.J., Wei,L., Yao,M., Wan,D.F. and Gu,J.R. TITLE Inhibitory effect of CT120B, an alternative splice...","source":"Homo sapiens (human)","symbol":"TLCD3A","synonym":"CT120; FAM57A","version":"NM_001318007.2"},{"aa_position":[],"accession":"NM_178432","definition":"Homo sapiens cyclin dependent kinase 20 (CDK20), transcript variant 1, mRNA.","division":"RefSeq","geneid":"23552","gi":"","length":"2125","nt_position":[],"snippet":"Shokat,K.M. and Fisher,R.P. TITLE The cyclin-dependent kinase (CDK) family member PNQALRE/CCRK supports cell proliferation but has no intrinsic CDK-activating kinase (CAK) activity JOURNAL Cell Cycle 5 (5), 546-554 (2006) PUBMED 16552187 REMARK GeneRIF: Depletion of PNQALRE by >80% due to RNA interference (RNAi) impairs cell proliferation, but fails to arrest the cell cycle at a discrete point. REFERENCE 10 (bases 1 to 2125) AUTHORS Liu,Y., Wu,C. and Galaktionov,K. TITLE p42, a novel cyclin-dependent kinase-activating kinase in mammalian cells JOURNAL J Biol Chem 279 (6), 4507-4514 (2004)...","source":"Homo sapiens (human)","symbol":"CDK20","synonym":"CCRK; CDCH; P42; PNQALRE","version":"NM_178432.4"},{"aa_position":[],"accession":"NM_177422","definition":"Homo sapiens argonaute RISC catalytic component 3 (AGO3), transcript variant 2, mRNA.","division":"RefSeq","geneid":"192669","gi":"","length":"19402","nt_position":[],"snippet":"has been curated by NCBI staff. The reference sequence was derived from BF979526.1, BC025769.1, BX104163.1, AA251146.1 and AL138787.11. On May 31, 2019 this sequence version replaced NM_177422.2. Summary: This gene encodes a member of the Argonaute family of proteins which play a role in RNA interference. The encoded protein is highly basic, contains a PAZ domain and a PIWI domain, and may play a role in short-interfering-RNA-mediated gene silencing. This gene is located on chromosome 1 in a tandem cluster of closely related family members including argonaute 4 and eukaryotic translation...","source":"Homo sapiens (human)","symbol":"AGO3","synonym":"EIF2C3","version":"NM_177422.3"},{"aa_position":[],"accession":"NR_136243","definition":"Homo sapiens transmembrane protein 167B (TMEM167B), transcript variant 4, non-coding RNA.","division":"RefSeq","geneid":"56900","gi":"","length":"2637","nt_position":[],"snippet":"TITLE A reference map of the human binary protein interactome JOURNAL Nature 580 (7803), 402-408 (2020) PUBMED 32296183 REFERENCE 2 (bases 1 to 2637) AUTHORS Wendler F, Gillingham AK, Sinka R, Rosa-Ferreira C, Gordon DE, Franch-Marro X, Peden AA, Vincent JP and Munro S. TITLE A genome-wide RNA interference screen identifies two novel components of the metazoan secretory pathway JOURNAL EMBO J. 29 (2), 304-314 (2010) PUBMED 19942856 REFERENCE 3 (bases 1 to 2637) AUTHORS Hu RM, Han ZG, Song HD, Peng YD, Huang QH, Ren SX, Gu YJ, Huang CH, Li YB, Jiang CL, Fu G, Zhang QH, Gu BW, Dai M, Mao YF, Gao...","source":"Homo sapiens (human)","symbol":"TMEM167B","synonym":"AD-020; C1orf119","version":"NR_136243.2"},{"aa_position":[],"accession":"NM_001039803","definition":"Homo sapiens cyclin dependent kinase 20 (CDK20), transcript variant 3, mRNA.","division":"RefSeq","geneid":"23552","gi":"","length":"2149","nt_position":[],"snippet":"Shokat,K.M. and Fisher,R.P. TITLE The cyclin-dependent kinase (CDK) family member PNQALRE/CCRK supports cell proliferation but has no intrinsic CDK-activating kinase (CAK) activity JOURNAL Cell Cycle 5 (5), 546-554 (2006) PUBMED 16552187 REMARK GeneRIF: Depletion of PNQALRE by >80% due to RNA interference (RNAi) impairs cell proliferation, but fails to arrest the cell cycle at a discrete point. REFERENCE 10 (bases 1 to 2149) AUTHORS Liu,Y., Wu,C. and Galaktionov,K. TITLE p42, a novel cyclin-dependent kinase-activating kinase in mammalian cells JOURNAL J Biol Chem 279 (6), 4507-4514 (2004)...","source":"Homo sapiens (human)","symbol":"CDK20","synonym":"CCRK; CDCH; P42; PNQALRE","version":"NM_001039803.3"},{"aa_position":[],"accession":"NM_001322248","definition":"Homo sapiens transmembrane protein 167B (TMEM167B), transcript variant 2, mRNA.","division":"RefSeq","geneid":"56900","gi":"","length":"2830","nt_position":[],"snippet":"map of the human binary protein interactome JOURNAL Nature 580 (7803), 402-408 (2020) PUBMED 32296183 REFERENCE 2 (bases 1 to 2830) AUTHORS Wendler,F., Gillingham,A.K., Sinka,R., Rosa-Ferreira,C., Gordon,D.E., Franch-Marro,X., Peden,A.A., Vincent,J.P. and Munro,S. TITLE A genome-wide RNA interference screen identifies two novel components of the metazoan secretory pathway JOURNAL EMBO J 29 (2), 304-314 (2010) PUBMED 19942856 REFERENCE 3 (bases 1 to 2830) AUTHORS Hu,R.M., Han,Z.G., Song,H.D., Peng,Y.D., Huang,Q.H., Ren,S.X., Gu,Y.J., Huang,C.H., Li,Y.B., Jiang,C.L., Fu,G., Zhang,Q.H., Gu,B.W.,...","source":"Homo sapiens (human)","symbol":"TMEM167B","synonym":"AD-020; C1orf119","version":"NM_001322248.2"},{"aa_position":[],"accession":"NM_024852","definition":"Homo sapiens argonaute RISC catalytic component 3 (AGO3), transcript variant 1, mRNA.","division":"RefSeq","geneid":"192669","gi":"","length":"19660","nt_position":[],"snippet":"by NCBI staff. The reference sequence was derived from BF979526.1, AL139286.13, AL138787.11, AK303929.1, BX104163.1 and AA251146.1. On Nov 23, 2018 this sequence version replaced NM_024852.3. Summary: This gene encodes a member of the Argonaute family of proteins which play a role in RNA interference. The encoded protein is highly basic, contains a PAZ domain and a PIWI domain, and may play a role in short-interfering-RNA-mediated gene silencing. This gene is located on chromosome 1 in a tandem cluster of closely related family members including argonaute 4 and eukaryotic translation...","source":"Homo sapiens (human)","symbol":"AGO3","synonym":"EIF2C3","version":"NM_024852.4"},{"aa_position":[],"accession":"NM_001378076","definition":"Homo sapiens G protein-coupled receptor 137 (GPR137), transcript variant 6, mRNA.","division":"RefSeq","geneid":"56834","gi":"","length":"1485","nt_position":[],"snippet":"urinary bladder cancer cell growth Erratum:[Biotechnol Appl Biochem. 2023 Aug;70(4):1560. doi: 10.1002/bab.2499. PMID: 37559496] REFERENCE 7 (bases 1 to 1485) AUTHORS Shao,X., Liu,Y., Huang,H., Zhuang,L., Luo,T., Huang,H. and Ge,X. TITLE Down-regulation of G protein-coupled receptor 137 by RNA interference inhibits cell growth of two hepatoma cell lines JOURNAL Cell Biol Int 39 (4), 418-426 (2015) PUBMED 25490967 REMARK GeneRIF: Knockdown of GPR137 in HepG2 cells led to cell cycle arrest at G0/G1 phase and G2/M phase, and induced cell apoptosis, as determined by flow cytometry analysis, which...","source":"Homo sapiens (human)","symbol":"GPR137","synonym":"C11orf4; GPR137A; TM7SF1L1","version":"NM_001378076.1"},{"aa_position":[],"accession":"NM_001305792","definition":"Homo sapiens kinesin family member 14 (KIF14), transcript variant 2, mRNA.","division":"RefSeq","geneid":"9928","gi":"","length":"6881","nt_position":[],"snippet":"PUBMED 16570270 REMARK GeneRIF: KIF14 is overexpressed in primary breast cancer; predicts disease-free and overall survival REFERENCE 6 (bases 1 to 6881) AUTHORS Carleton,M., Mao,M., Biery,M., Warrener,P., Kim,S., Buser,C., Marshall,C.G., Fernandes,C., Annis,J. and Linsley,P.S. TITLE RNA interference-mediated silencing of mitotic kinesin KIF14 disrupts cell cycle progression and induces cytokinesis failure JOURNAL Mol Cell Biol 26 (10), 3853-3863 (2006) PUBMED 16648480 REMARK GeneRIF: RNA interference-mediated silencing of KIF14 disrupts cell cycle progression and induces cytokinesis failure....","source":"Homo sapiens (human)","symbol":"KIF14","synonym":"MCPH20; MKS12","version":"NM_001305792.1"},{"aa_position":[],"accession":"NM_001354638","definition":"Homo sapiens exoribonuclease 1 (ERI1), transcript variant 2, mRNA.","division":"RefSeq","geneid":"90459","gi":"","length":"1330","nt_position":[],"snippet":"Data describe the structure of the nuclease domain of 3'-5'-exoribonuclease (3'hExo) complexed with rAMP in the presence of magnesium at 1.6 A resolution. REFERENCE 9 (bases 1 to 1330) AUTHORS Kennedy,S., Wang,D. and Ruvkun,G. TITLE A conserved siRNA-degrading RNase negatively regulates RNA interference in C. elegans JOURNAL Nature 427 (6975), 645-649 (2004) PUBMED 14961122 REMARK GeneRIF: molecular cloning; degrades siRNAs in vitro[ERI-1] REFERENCE 10 (bases 1 to 1330) AUTHORS Dominski,Z., Yang,X.C., Kaygun,H., Dadlez,M. and Marzluff,W.F. TITLE A 3' exonuclease that specifically interacts...","source":"Homo sapiens (human)","symbol":"ERI1","synonym":"3'HEXO; HEXO; HXAL; SEMDGC; SEMDGS; THEX1","version":"NM_001354638.2"},{"aa_position":[],"accession":"NM_001318006","definition":"Homo sapiens TLC domain containing 3A (TLCD3A), transcript variant 2, mRNA.","division":"RefSeq","geneid":"79850","gi":"","length":"2128","nt_position":[],"snippet":"GeneRIF: The researchers found evidence that CT120 may be a key factor in tumor progression and that down-regulation of CT120 may be an effective treatment for lung neoplasms. REFERENCE 3 (bases 1 to 2128) AUTHORS Pan,D., Wei,L., Yao,M., Wan,D. and Gu,J. TITLE Down-regulation of CT120A by RNA interference suppresses lung cancer cells growth and sensitizes to ultraviolet-induced apoptosis JOURNAL Cancer Lett 235 (1), 26-33 (2006) PUBMED 15927361 REFERENCE 4 (bases 1 to 2128) AUTHORS Pan,D.N., Li,J.J., Wei,L., Yao,M., Wan,D.F. and Gu,J.R. TITLE Inhibitory effect of CT120B, an alternative splice...","source":"Homo sapiens (human)","symbol":"TLCD3A","synonym":"CT120; FAM57A","version":"NM_001318006.2"},{"aa_position":[],"accession":"NM_001378084","definition":"Homo sapiens G protein-coupled receptor 137 (GPR137), transcript variant 14, mRNA.","division":"RefSeq","geneid":"56834","gi":"","length":"1516","nt_position":[],"snippet":"urinary bladder cancer cell growth Erratum:[Biotechnol Appl Biochem. 2023 Aug;70(4):1560. doi: 10.1002/bab.2499. PMID: 37559496] REFERENCE 7 (bases 1 to 1516) AUTHORS Shao,X., Liu,Y., Huang,H., Zhuang,L., Luo,T., Huang,H. and Ge,X. TITLE Down-regulation of G protein-coupled receptor 137 by RNA interference inhibits cell growth of two hepatoma cell lines JOURNAL Cell Biol Int 39 (4), 418-426 (2015) PUBMED 25490967 REMARK GeneRIF: Knockdown of GPR137 in HepG2 cells led to cell cycle arrest at G0/G1 phase and G2/M phase, and induced cell apoptosis, as determined by flow cytometry analysis, which...","source":"Homo sapiens (human)","symbol":"GPR137","synonym":"C11orf4; GPR137A; TM7SF1L1","version":"NM_001378084.1"},{"aa_position":[],"accession":"NR_136242","definition":"Homo sapiens transmembrane protein 167B (TMEM167B), transcript variant 3, non-coding RNA.","division":"RefSeq","geneid":"56900","gi":"","length":"2858","nt_position":[],"snippet":"TITLE A reference map of the human binary protein interactome JOURNAL Nature 580 (7803), 402-408 (2020) PUBMED 32296183 REFERENCE 2 (bases 1 to 2858) AUTHORS Wendler F, Gillingham AK, Sinka R, Rosa-Ferreira C, Gordon DE, Franch-Marro X, Peden AA, Vincent JP and Munro S. TITLE A genome-wide RNA interference screen identifies two novel components of the metazoan secretory pathway JOURNAL EMBO J. 29 (2), 304-314 (2010) PUBMED 19942856 REFERENCE 3 (bases 1 to 2858) AUTHORS Hu RM, Han ZG, Song HD, Peng YD, Huang QH, Ren SX, Gu YJ, Huang CH, Li YB, Jiang CL, Fu G, Zhang QH, Gu BW, Dai M, Mao YF, Gao...","source":"Homo sapiens (human)","symbol":"TMEM167B","synonym":"AD-020; C1orf119","version":"NR_136242.2"},{"aa_position":[],"accession":"NM_139160","definition":"Homo sapiens DEP domain containing 7 (DEPDC7), transcript variant 2, mRNA.","division":"RefSeq","geneid":"91614","gi":"","length":"2059","nt_position":[],"snippet":"PUBMED 29344171 REFERENCE 2 (bases 1 to 2059) AUTHORS Liao,Z., Wang,X., Lin,D. and Zou,Q. TITLE Construction and Identification of the RNAi Recombinant Lentiviral Vector Targeting Human DEPDC7 Gene JOURNAL Interdiscip Sci 9 (3), 350-356 (2017) PUBMED 27016254 REMARK GeneRIF: RNA interference (RNAi) recombinant lentiviral vector particle targeting DEPDC7 was constructed in order to knockdown its gene expression in human hepatocellular carcinoma cell line HepG2. REFERENCE 3 (bases 1 to 2059) AUTHORS Cordova-Palomera,A., Fatjo-Vilas,M., Palma-Gudiel,H., Blasco-Fontecilla,H., Kebir,O. and Fananas,...","source":"Homo sapiens (human)","symbol":"DEPDC7","synonym":"dJ85M6.4; TR2","version":"NM_139160.3"},{"aa_position":[],"accession":"NM_014875","definition":"Homo sapiens kinesin family member 14 (KIF14), transcript variant 1, mRNA.","division":"RefSeq","geneid":"9928","gi":"","length":"7291","nt_position":[],"snippet":"PUBMED 16570270 REMARK GeneRIF: KIF14 is overexpressed in primary breast cancer; predicts disease-free and overall survival REFERENCE 6 (bases 1 to 7291) AUTHORS Carleton,M., Mao,M., Biery,M., Warrener,P., Kim,S., Buser,C., Marshall,C.G., Fernandes,C., Annis,J. and Linsley,P.S. TITLE RNA interference-mediated silencing of mitotic kinesin KIF14 disrupts cell cycle progression and induces cytokinesis failure JOURNAL Mol Cell Biol 26 (10), 3853-3863 (2006) PUBMED 16648480 REMARK GeneRIF: RNA interference-mediated silencing of KIF14 disrupts cell cycle progression and induces cytokinesis failure....","source":"Homo sapiens (human)","symbol":"KIF14","synonym":"MCPH20; MKS12","version":"NM_014875.3"},{"aa_position":[],"accession":"NM_001015509","definition":"Homo sapiens peptidyl-tRNA hydrolase 2 (PTRH2), transcript variant 1, mRNA; nuclear gene for mitochondrial product.","division":"RefSeq","geneid":"51651","gi":"","length":"2050","nt_position":[],"snippet":"mediates integrin-dependent cell survival through activation of the NFkappaB pathway REFERENCE 6 (bases 1 to 2050) AUTHORS Fan,T., Jiang,G., Suo,Z., Liu,H., Xu,P., Ji,Z., Zhang,L. and Yang,G. TITLE Down-regulation of the apoptosis-inducing factor or Bcl-2 inhibitor of transcription by RNA interference can alleviate TAp63gamma-induced apoptosis in esophageal squamous carcinoma EC9706 cells JOURNAL Int J Oncol 35 (2), 359-367 (2009) PUBMED 19578750 REMARK GeneRIF: TAp63gamma could induce apoptosis in human esophageal squamous cancer EC9706 cells, through at least releasing AIF and Bit1 from...","source":"Homo sapiens (human)","symbol":"PTRH2","synonym":"BIT1; CFAP37; CGI-147; IMNEPD; PTH; PTH 2; PTH2","version":"NM_001015509.3"},{"aa_position":[],"accession":"NM_001378080","definition":"Homo sapiens G protein-coupled receptor 137 (GPR137), transcript variant 10, mRNA.","division":"RefSeq","geneid":"56834","gi":"","length":"1607","nt_position":[],"snippet":"urinary bladder cancer cell growth Erratum:[Biotechnol Appl Biochem. 2023 Aug;70(4):1560. doi: 10.1002/bab.2499. PMID: 37559496] REFERENCE 7 (bases 1 to 1607) AUTHORS Shao,X., Liu,Y., Huang,H., Zhuang,L., Luo,T., Huang,H. and Ge,X. TITLE Down-regulation of G protein-coupled receptor 137 by RNA interference inhibits cell growth of two hepatoma cell lines JOURNAL Cell Biol Int 39 (4), 418-426 (2015) PUBMED 25490967 REMARK GeneRIF: Knockdown of GPR137 in HepG2 cells led to cell cycle arrest at G0/G1 phase and G2/M phase, and induced cell apoptosis, as determined by flow cytometry analysis, which...","source":"Homo sapiens (human)","symbol":"GPR137","synonym":"C11orf4; GPR137A; TM7SF1L1","version":"NM_001378080.1"},{"aa_position":[],"accession":"NR_136629","definition":"Homo sapiens taspase 1 (TASP1), transcript variant 6, non-coding RNA.","division":"RefSeq","geneid":"55617","gi":"","length":"2155","nt_position":[],"snippet":"Hsieh JJ, Mitsiou DJ, Hoiby T, Veenstra GJ, Korsmeyer SJ and Stunnenberg HG. TITLE Uncleaved TFIIA is a substrate for taspase 1 and active in transcription JOURNAL Mol Cell Biol 26 (7), 2728-2735 (2006) PUBMED 16537915 REMARK GeneRIF: Transfected taspase 1 enhances cleavage of TFIIA, and RNA interference knockdown of endogenous taspase 1 diminishes cleavage of TFIIA in vivo. REFERENCE 7 (bases 1 to 2155) AUTHORS Khan JA, Dunn BM and Tong L. TITLE Crystal structure of human Taspase1, a crucial protease regulating the function of MLL JOURNAL Structure 13 (10), 1443-1452 (2005) PUBMED 16216576...","source":"Homo sapiens (human)","symbol":"TASP1","synonym":"C20orf13; dJ585I14.2; SULEHS","version":"NR_136629.2"},{"aa_position":[],"accession":"NM_024792","definition":"Homo sapiens TLC domain containing 3A (TLCD3A), transcript variant 1, mRNA.","division":"RefSeq","geneid":"79850","gi":"","length":"2224","nt_position":[],"snippet":"GeneRIF: The researchers found evidence that CT120 may be a key factor in tumor progression and that down-regulation of CT120 may be an effective treatment for lung neoplasms. REFERENCE 3 (bases 1 to 2224) AUTHORS Pan,D., Wei,L., Yao,M., Wan,D. and Gu,J. TITLE Down-regulation of CT120A by RNA interference suppresses lung cancer cells growth and sensitizes to ultraviolet-induced apoptosis JOURNAL Cancer Lett 235 (1), 26-33 (2006) PUBMED 15927361 REFERENCE 4 (bases 1 to 2224) AUTHORS Pan,D.N., Li,J.J., Wei,L., Yao,M., Wan,D.F. and Gu,J.R. TITLE Inhibitory effect of CT120B, an alternative splice...","source":"Homo sapiens (human)","symbol":"TLCD3A","synonym":"CT120; FAM57A","version":"NM_024792.3"},{"aa_position":[],"accession":"NM_001378078","definition":"Homo sapiens G protein-coupled receptor 137 (GPR137), transcript variant 8, mRNA.","division":"RefSeq","geneid":"56834","gi":"","length":"1635","nt_position":[],"snippet":"urinary bladder cancer cell growth Erratum:[Biotechnol Appl Biochem. 2023 Aug;70(4):1560. doi: 10.1002/bab.2499. PMID: 37559496] REFERENCE 7 (bases 1 to 1635) AUTHORS Shao,X., Liu,Y., Huang,H., Zhuang,L., Luo,T., Huang,H. and Ge,X. TITLE Down-regulation of G protein-coupled receptor 137 by RNA interference inhibits cell growth of two hepatoma cell lines JOURNAL Cell Biol Int 39 (4), 418-426 (2015) PUBMED 25490967 REMARK GeneRIF: Knockdown of GPR137 in HepG2 cells led to cell cycle arrest at G0/G1 phase and G2/M phase, and induced cell apoptosis, as determined by flow cytometry analysis, which...","source":"Homo sapiens (human)","symbol":"GPR137","synonym":"C11orf4; GPR137A; TM7SF1L1","version":"NM_001378078.1"},{"aa_position":[],"accession":"NM_001365710","definition":"Homo sapiens vesicle transport through interaction with t-SNAREs 1A (VTI1A), transcript variant 7, mRNA.","division":"RefSeq","geneid":"143187","gi":"","length":"1795","nt_position":[],"snippet":"of colorectal adenocarcinomas identifies a recurrent VTI1A-TCF7L2 fusion JOURNAL Nat Genet 43 (10), 964-968 (2011) PUBMED 21892161 REMARK GeneRIF: We found a colorectal carcinoma cell line harboring the fusion gene to be dependent on VTI1A-TCF7L2 for anchorage-independent growth using RNA interference-mediated knockdown. Publication Status: Online-Only REFERENCE 6 (bases 1 to 1795) AUTHORS Flowerdew,S.E. and Burgoyne,R.D. TITLE A VAMP7/Vti1a SNARE complex distinguishes a non-conventional traffic route to the cell surface used by KChIP1 and Kv4 potassium channels JOURNAL Biochem J...","source":"Homo sapiens (human)","symbol":"VTI1A","synonym":"MMDS3; MVti1; Vti1-rp2; VTI1RP2","version":"NM_001365710.2"},{"aa_position":[],"accession":"NM_017714","definition":"Homo sapiens taspase 1 (TASP1), transcript variant 1, mRNA.","division":"RefSeq","geneid":"55617","gi":"","length":"2342","nt_position":[],"snippet":"J., Mitsiou,D.J., Hoiby,T., Veenstra,G.J., Korsmeyer,S.J. and Stunnenberg,H.G. TITLE Uncleaved TFIIA is a substrate for taspase 1 and active in transcription JOURNAL Mol Cell Biol 26 (7), 2728-2735 (2006) PUBMED 16537915 REMARK GeneRIF: Transfected taspase 1 enhances cleavage of TFIIA, and RNA interference knockdown of endogenous taspase 1 diminishes cleavage of TFIIA in vivo. REFERENCE 7 (bases 1 to 2342) AUTHORS Khan,J.A., Dunn,B.M. and Tong,L. TITLE Crystal structure of human Taspase1, a crucial protease regulating the function of MLL JOURNAL Structure 13 (10), 1443-1452 (2005) PUBMED...","source":"Homo sapiens (human)","symbol":"TASP1","synonym":"C20orf13; dJ585I14.2; SULEHS","version":"NM_017714.3"},{"aa_position":[],"accession":"NR_134522","definition":"Homo sapiens vesicle transport through interaction with t-SNAREs 1A (VTI1A), transcript variant 5, non-coding RNA.","division":"RefSeq","geneid":"143187","gi":"","length":"2206","nt_position":[],"snippet":"of colorectal adenocarcinomas identifies a recurrent VTI1A-TCF7L2 fusion JOURNAL Nat Genet 43 (10), 964-968 (2011) PUBMED 21892161 REMARK GeneRIF: We found a colorectal carcinoma cell line harboring the fusion gene to be dependent on VTI1A-TCF7L2 for anchorage-independent growth using RNA interference-mediated knockdown. Publication Status: Online-Only REFERENCE 6 (bases 1 to 2206) AUTHORS Flowerdew,S.E. and Burgoyne,R.D. TITLE A VAMP7/Vti1a SNARE complex distinguishes a non-conventional traffic route to the cell surface used by KChIP1 and Kv4 potassium channels JOURNAL Biochem J...","source":"Homo sapiens (human)","symbol":"VTI1A","synonym":"MMDS3; MVti1; Vti1-rp2; VTI1RP2","version":"NR_134522.2"},{"aa_position":[],"accession":"NR_134521","definition":"Homo sapiens vesicle transport through interaction with t-SNAREs 1A (VTI1A), transcript variant 4, non-coding RNA.","division":"RefSeq","geneid":"143187","gi":"","length":"2210","nt_position":[],"snippet":"of colorectal adenocarcinomas identifies a recurrent VTI1A-TCF7L2 fusion JOURNAL Nat Genet 43 (10), 964-968 (2011) PUBMED 21892161 REMARK GeneRIF: We found a colorectal carcinoma cell line harboring the fusion gene to be dependent on VTI1A-TCF7L2 for anchorage-independent growth using RNA interference-mediated knockdown. Publication Status: Online-Only REFERENCE 6 (bases 1 to 2210) AUTHORS Flowerdew,S.E. and Burgoyne,R.D. TITLE A VAMP7/Vti1a SNARE complex distinguishes a non-conventional traffic route to the cell surface used by KChIP1 and Kv4 potassium channels JOURNAL Biochem J...","source":"Homo sapiens (human)","symbol":"VTI1A","synonym":"MMDS3; MVti1; Vti1-rp2; VTI1RP2","version":"NR_134521.2"},{"aa_position":[],"accession":"NR_136628","definition":"Homo sapiens taspase 1 (TASP1), transcript variant 5, non-coding RNA.","division":"RefSeq","geneid":"55617","gi":"","length":"2222","nt_position":[],"snippet":"Hsieh JJ, Mitsiou DJ, Hoiby T, Veenstra GJ, Korsmeyer SJ and Stunnenberg HG. TITLE Uncleaved TFIIA is a substrate for taspase 1 and active in transcription JOURNAL Mol Cell Biol 26 (7), 2728-2735 (2006) PUBMED 16537915 REMARK GeneRIF: Transfected taspase 1 enhances cleavage of TFIIA, and RNA interference knockdown of endogenous taspase 1 diminishes cleavage of TFIIA in vivo. REFERENCE 7 (bases 1 to 2222) AUTHORS Khan JA, Dunn BM and Tong L. TITLE Crystal structure of human Taspase1, a crucial protease regulating the function of MLL JOURNAL Structure 13 (10), 1443-1452 (2005) PUBMED 16216576...","source":"Homo sapiens (human)","symbol":"TASP1","synonym":"C20orf13; dJ585I14.2; SULEHS","version":"NR_136628.2"},{"aa_position":[],"accession":"NM_001098576","definition":"Homo sapiens transmembrane BAX inhibitor motif containing 6 (TMBIM6), transcript variant 2, mRNA.","division":"RefSeq","geneid":"7009","gi":"","length":"3194","nt_position":[],"snippet":"human interactome JOURNAL Cell 184 (11), 3022-3040 (2021) PUBMED 33961781 REFERENCE 6 (bases 1 to 3194) AUTHORS Grzmil,M., Thelen,P., Hemmerlein,B., Schweyer,S., Voigt,S., Mury,D. and Burfeind,P. TITLE Bax inhibitor-1 is overexpressed in prostate cancer and its specific down-regulation by RNA interference leads to cell death in human prostate carcinoma cells JOURNAL Am J Pathol 163 (2), 543-552 (2003) PUBMED 12875974 REMARK GeneRIF: Results indicate that the human Bax inhibitor-1 gene may serve as a prostate cancer expression marker based on its overexpression in prostate carcinoma and...","source":"Homo sapiens (human)","symbol":"TMBIM6","synonym":"BAXI1; BI-1; TEGT","version":"NM_001098576.2"},{"aa_position":[],"accession":"NM_001323604","definition":"Homo sapiens taspase 1 (TASP1), transcript variant 4, mRNA.","division":"RefSeq","geneid":"55617","gi":"","length":"2417","nt_position":[],"snippet":"J., Mitsiou,D.J., Hoiby,T., Veenstra,G.J., Korsmeyer,S.J. and Stunnenberg,H.G. TITLE Uncleaved TFIIA is a substrate for taspase 1 and active in transcription JOURNAL Mol Cell Biol 26 (7), 2728-2735 (2006) PUBMED 16537915 REMARK GeneRIF: Transfected taspase 1 enhances cleavage of TFIIA, and RNA interference knockdown of endogenous taspase 1 diminishes cleavage of TFIIA in vivo. REFERENCE 7 (bases 1 to 2417) AUTHORS Khan,J.A., Dunn,B.M. and Tong,L. TITLE Crystal structure of human Taspase1, a crucial protease regulating the function of MLL JOURNAL Structure 13 (10), 1443-1452 (2005) PUBMED...","source":"Homo sapiens (human)","symbol":"TASP1","synonym":"C20orf13; dJ585I14.2; SULEHS","version":"NM_001323604.2"},{"aa_position":[],"accession":"NM_022899","definition":"Homo sapiens actin related protein 8 (ACTR8), transcript variant 1, mRNA.","division":"RefSeq","geneid":"93973","gi":"","length":"3579","nt_position":[],"snippet":"H. and Harata,M. TITLE The actin-related protein hArp8 accumulates on the mitotic chromosomes and functions in chromosome alignment JOURNAL Exp Cell Res 314 (4), 859-868 (2008) PUBMED 18163988 REMARK GeneRIF: Expression of truncated hArp8 proteins and depletion of endogenous hArp8 by RNA interference caused misalignment of mitotic chromosomes, suggesting that chromosome-associated hArp8 has a role in chromosome behavior. REFERENCE 8 (bases 1 to 3579) AUTHORS Wu,S., Shi,Y., Mulligan,P., Gay,F., Landry,J., Liu,H., Lu,J., Qi,H.H., Wang,W., Nickoloff,J.A., Wu,C. and Shi,Y. TITLE A YY1-INO80...","source":"Homo sapiens (human)","symbol":"ACTR8","synonym":"ARP8; hArp8; INO80N","version":"NM_022899.5"},{"aa_position":[],"accession":"NM_001365711","definition":"Homo sapiens vesicle transport through interaction with t-SNAREs 1A (VTI1A), transcript variant 8, mRNA.","division":"RefSeq","geneid":"143187","gi":"","length":"2533","nt_position":[],"snippet":"of colorectal adenocarcinomas identifies a recurrent VTI1A-TCF7L2 fusion JOURNAL Nat Genet 43 (10), 964-968 (2011) PUBMED 21892161 REMARK GeneRIF: We found a colorectal carcinoma cell line harboring the fusion gene to be dependent on VTI1A-TCF7L2 for anchorage-independent growth using RNA interference-mediated knockdown. Publication Status: Online-Only REFERENCE 6 (bases 1 to 2533) AUTHORS Flowerdew,S.E. and Burgoyne,R.D. TITLE A VAMP7/Vti1a SNARE complex distinguishes a non-conventional traffic route to the cell surface used by KChIP1 and Kv4 potassium channels JOURNAL Biochem J...","source":"Homo sapiens (human)","symbol":"VTI1A","synonym":"MMDS3; MVti1; Vti1-rp2; VTI1RP2","version":"NM_001365711.1"},{"aa_position":[],"accession":"NM_001365713","definition":"Homo sapiens vesicle transport through interaction with t-SNAREs 1A (VTI1A), transcript variant 10, mRNA.","division":"RefSeq","geneid":"143187","gi":"","length":"2544","nt_position":[],"snippet":"of colorectal adenocarcinomas identifies a recurrent VTI1A-TCF7L2 fusion JOURNAL Nat Genet 43 (10), 964-968 (2011) PUBMED 21892161 REMARK GeneRIF: We found a colorectal carcinoma cell line harboring the fusion gene to be dependent on VTI1A-TCF7L2 for anchorage-independent growth using RNA interference-mediated knockdown. Publication Status: Online-Only REFERENCE 6 (bases 1 to 2544) AUTHORS Flowerdew,S.E. and Burgoyne,R.D. TITLE A VAMP7/Vti1a SNARE complex distinguishes a non-conventional traffic route to the cell surface used by KChIP1 and Kv4 potassium channels JOURNAL Biochem J...","source":"Homo sapiens (human)","symbol":"VTI1A","synonym":"MMDS3; MVti1; Vti1-rp2; VTI1RP2","version":"NM_001365713.1"},{"aa_position":[],"accession":"NM_001378089","definition":"Homo sapiens G protein-coupled receptor 137 (GPR137), transcript variant 19, mRNA.","division":"RefSeq","geneid":"56834","gi":"","length":"1735","nt_position":[],"snippet":"urinary bladder cancer cell growth Erratum:[Biotechnol Appl Biochem. 2023 Aug;70(4):1560. doi: 10.1002/bab.2499. PMID: 37559496] REFERENCE 7 (bases 1 to 1735) AUTHORS Shao,X., Liu,Y., Huang,H., Zhuang,L., Luo,T., Huang,H. and Ge,X. TITLE Down-regulation of G protein-coupled receptor 137 by RNA interference inhibits cell growth of two hepatoma cell lines JOURNAL Cell Biol Int 39 (4), 418-426 (2015) PUBMED 25490967 REMARK GeneRIF: Knockdown of GPR137 in HepG2 cells led to cell cycle arrest at G0/G1 phase and G2/M phase, and induced cell apoptosis, as determined by flow cytometry analysis, which...","source":"Homo sapiens (human)","symbol":"GPR137","synonym":"C11orf4; GPR137A; TM7SF1L1","version":"NM_001378089.1"},{"aa_position":[],"accession":"NM_001128211","definition":"Homo sapiens NudC domain containing 1 (NUDCD1), transcript variant 2, mRNA.","division":"RefSeq","geneid":"84955","gi":"","length":"3854","nt_position":[],"snippet":"chaperone interaction network reveals the architecture of cellular protein homeostasis pathways JOURNAL Cell 158 (2), 434-448 (2014) PUBMED 25036637 REFERENCE 7 (bases 1 to 3854) AUTHORS Wang,Q., Li,M., Wang,Y., Zhang,Y., Jin,S., Xie,G., Liu,Z., Wang,S., Zhang,H., Shen,L. and Ge,H. TITLE RNA interference targeting CML66, a novel tumor antigen, inhibits proliferation, invasion and metastasis of HeLa cells JOURNAL Cancer Lett 269 (1), 127-138 (2008) PUBMED 18534745 REMARK GeneRIF: CML66 may play an oncogenic role in ways of favoring tumor cells proliferation, invasion and metastasis-associated...","source":"Homo sapiens (human)","symbol":"NUDCD1","synonym":"CML66; OVA66","version":"NM_001128211.2"},{"aa_position":[],"accession":"NM_001378081","definition":"Homo sapiens G protein-coupled receptor 137 (GPR137), transcript variant 11, mRNA.","division":"RefSeq","geneid":"56834","gi":"","length":"1742","nt_position":[],"snippet":"urinary bladder cancer cell growth Erratum:[Biotechnol Appl Biochem. 2023 Aug;70(4):1560. doi: 10.1002/bab.2499. PMID: 37559496] REFERENCE 7 (bases 1 to 1742) AUTHORS Shao,X., Liu,Y., Huang,H., Zhuang,L., Luo,T., Huang,H. and Ge,X. TITLE Down-regulation of G protein-coupled receptor 137 by RNA interference inhibits cell growth of two hepatoma cell lines JOURNAL Cell Biol Int 39 (4), 418-426 (2015) PUBMED 25490967 REMARK GeneRIF: Knockdown of GPR137 in HepG2 cells led to cell cycle arrest at G0/G1 phase and G2/M phase, and induced cell apoptosis, as determined by flow cytometry analysis, which...","source":"Homo sapiens (human)","symbol":"GPR137","synonym":"C11orf4; GPR137A; TM7SF1L1","version":"NM_001378081.1"},{"aa_position":[],"accession":"NR_146062","definition":"Homo sapiens argonaute RISC component 4 (AGO4), transcript variant 2, non-coding RNA.","division":"RefSeq","geneid":"192670","gi":"","length":"5087","nt_position":[],"snippet":"curated by NCBI staff. The reference sequence was derived from AL354864.16 and AL359186.15. On Jun 1, 2019 this sequence version replaced NR_146062.1. Summary: This gene encodes a member of the Argonaute family of proteins which contain PAZ and PIWI domains and play an integral role in RNA interference and short-interfering-RNA-mediated gene silencing. This gene is located on chromosome 1 in a cluster of related family members. [provided by RefSeq, Mar 2017]. Transcript Variant: This variant (2) differs at both the 5' and 3' ends compared to variant 1. This variant is represented as non-coding...","source":"Homo sapiens (human)","symbol":"AGO4","synonym":"EIF2C4","version":"NR_146062.2"},{"aa_position":[],"accession":"NM_015388","definition":"Homo sapiens Yip1 domain family member 3 (YIPF3), mRNA.","division":"RefSeq","geneid":"25844","gi":"","length":"1507","nt_position":[],"snippet":"Shields,D.C. and Simpson,J.C. TITLE Functional characterisation of the YIPF protein family in mammalian cells JOURNAL Histochem Cell Biol 147 (4), 439-451 (2017) PUBMED 274 REMARK GeneRIF: The significance of YIPF3 protein for the maintenance of the morphology of the Golgi was tested by RNA interference, revealing a number of specific morphological changes to this organelle on their depletion. REFERENCE 6 (bases 1 to 1507) AUTHORS Tanimoto,K., Suzuki,K., Jokitalo,E., Sakai,N., Sakaguchi,T., Tamura,D., Fujii,G., Aoki,K., Takada,S., Ishida,R., Tanabe,M., Itoh,H., Yoneda,Y., Sohda,M., Misumi,Y....","source":"Homo sapiens (human)","symbol":"YIPF3","synonym":"C6orf109; dJ337H4.3; FinGER3; KLIP1; Yip5b; YIPFbeta2","version":"NM_015388.4"},{"aa_position":[],"accession":"NR_136630","definition":"Homo sapiens taspase 1 (TASP1), transcript variant 7, non-coding RNA.","division":"RefSeq","geneid":"55617","gi":"","length":"2409","nt_position":[],"snippet":"Hsieh JJ, Mitsiou DJ, Hoiby T, Veenstra GJ, Korsmeyer SJ and Stunnenberg HG. TITLE Uncleaved TFIIA is a substrate for taspase 1 and active in transcription JOURNAL Mol Cell Biol 26 (7), 2728-2735 (2006) PUBMED 16537915 REMARK GeneRIF: Transfected taspase 1 enhances cleavage of TFIIA, and RNA interference knockdown of endogenous taspase 1 diminishes cleavage of TFIIA in vivo. REFERENCE 7 (bases 1 to 2409) AUTHORS Khan JA, Dunn BM and Tong L. TITLE Crystal structure of human Taspase1, a crucial protease regulating the function of MLL JOURNAL Structure 13 (10), 1443-1452 (2005) PUBMED 16216576...","source":"Homo sapiens (human)","symbol":"TASP1","synonym":"C20orf13; dJ585I14.2; SULEHS","version":"NR_136630.2"},{"aa_position":[],"accession":"NM_001001557","definition":"Homo sapiens growth differentiation factor 6 (GDF6), mRNA.","division":"RefSeq","geneid":"392255","gi":"","length":"3712","nt_position":[],"snippet":"JOURNAL Genes (Basel) 12 (9), 1354 (2021) PUBMED 34573339 REMARK GeneRIF: GDF6 Knockdown in a Family with Multiple Synostosis Syndrome and Speech Impairment. Publication Status: Online-Only REFERENCE 4 (bases 1 to 3712) AUTHORS Fang,Z., Zhao,Z., Eapen,V. and Clarke,R.A. TITLE siRNA Mediate RNA Interference Concordant with Early On-Target Transient Transcriptional Interference JOURNAL Genes (Basel) 12 (8), 1290 (2021) PUBMED 34440463 REMARK GeneRIF: siRNA Mediate RNA Interference Concordant with Early On-Target Transient Transcriptional Interference. Publication Status: Online-Only REFERENCE...","source":"Homo sapiens (human)","symbol":"GDF6","synonym":"BMP-13; BMP13; CDMP2; KFM; KFS; KFS1; KFSL; SGM1; SYNS4","version":"NM_001001557.4"},{"aa_position":[],"accession":"NM_001378087","definition":"Homo sapiens G protein-coupled receptor 137 (GPR137), transcript variant 17, mRNA.","division":"RefSeq","geneid":"56834","gi":"","length":"1786","nt_position":[],"snippet":"urinary bladder cancer cell growth Erratum:[Biotechnol Appl Biochem. 2023 Aug;70(4):1560. doi: 10.1002/bab.2499. PMID: 37559496] REFERENCE 7 (bases 1 to 1786) AUTHORS Shao,X., Liu,Y., Huang,H., Zhuang,L., Luo,T., Huang,H. and Ge,X. TITLE Down-regulation of G protein-coupled receptor 137 by RNA interference inhibits cell growth of two hepatoma cell lines JOURNAL Cell Biol Int 39 (4), 418-426 (2015) PUBMED 25490967 REMARK GeneRIF: Knockdown of GPR137 in HepG2 cells led to cell cycle arrest at G0/G1 phase and G2/M phase, and induced cell apoptosis, as determined by flow cytometry analysis, which...","source":"Homo sapiens (human)","symbol":"GPR137","synonym":"C11orf4; GPR137A; TM7SF1L1","version":"NM_001378087.1"},{"aa_position":[],"accession":"NM_001323603","definition":"Homo sapiens taspase 1 (TASP1), transcript variant 3, mRNA.","division":"RefSeq","geneid":"55617","gi":"","length":"2609","nt_position":[],"snippet":"J., Mitsiou,D.J., Hoiby,T., Veenstra,G.J., Korsmeyer,S.J. and Stunnenberg,H.G. TITLE Uncleaved TFIIA is a substrate for taspase 1 and active in transcription JOURNAL Mol Cell Biol 26 (7), 2728-2735 (2006) PUBMED 16537915 REMARK GeneRIF: Transfected taspase 1 enhances cleavage of TFIIA, and RNA interference knockdown of endogenous taspase 1 diminishes cleavage of TFIIA in vivo. REFERENCE 7 (bases 1 to 2609) AUTHORS Khan,J.A., Dunn,B.M. and Tong,L. TITLE Crystal structure of human Taspase1, a crucial protease regulating the function of MLL JOURNAL Structure 13 (10), 1443-1452 (2005) PUBMED...","source":"Homo sapiens (human)","symbol":"TASP1","synonym":"C20orf13; dJ585I14.2; SULEHS","version":"NM_001323603.2"},{"aa_position":[],"accession":"NM_032869","definition":"Homo sapiens NudC domain containing 1 (NUDCD1), transcript variant 1, mRNA.","division":"RefSeq","geneid":"84955","gi":"","length":"3919","nt_position":[],"snippet":"chaperone interaction network reveals the architecture of cellular protein homeostasis pathways JOURNAL Cell 158 (2), 434-448 (2014) PUBMED 25036637 REFERENCE 7 (bases 1 to 3919) AUTHORS Wang,Q., Li,M., Wang,Y., Zhang,Y., Jin,S., Xie,G., Liu,Z., Wang,S., Zhang,H., Shen,L. and Ge,H. TITLE RNA interference targeting CML66, a novel tumor antigen, inhibits proliferation, invasion and metastasis of HeLa cells JOURNAL Cancer Lett 269 (1), 127-138 (2008) PUBMED 18534745 REMARK GeneRIF: CML66 may play an oncogenic role in ways of favoring tumor cells proliferation, invasion and metastasis-associated...","source":"Homo sapiens (human)","symbol":"NUDCD1","synonym":"CML66; OVA66","version":"NM_032869.4"},{"aa_position":[],"accession":"NR_136631","definition":"Homo sapiens taspase 1 (TASP1), transcript variant 8, non-coding RNA.","division":"RefSeq","geneid":"55617","gi":"","length":"2489","nt_position":[],"snippet":"Hsieh JJ, Mitsiou DJ, Hoiby T, Veenstra GJ, Korsmeyer SJ and Stunnenberg HG. TITLE Uncleaved TFIIA is a substrate for taspase 1 and active in transcription JOURNAL Mol Cell Biol 26 (7), 2728-2735 (2006) PUBMED 16537915 REMARK GeneRIF: Transfected taspase 1 enhances cleavage of TFIIA, and RNA interference knockdown of endogenous taspase 1 diminishes cleavage of TFIIA in vivo. REFERENCE 7 (bases 1 to 2489) AUTHORS Khan JA, Dunn BM and Tong L. TITLE Crystal structure of human Taspase1, a crucial protease regulating the function of MLL JOURNAL Structure 13 (10), 1443-1452 (2005) PUBMED 16216576...","source":"Homo sapiens (human)","symbol":"TASP1","synonym":"C20orf13; dJ585I14.2; SULEHS","version":"NR_136631.2"},{"aa_position":[],"accession":"NM_001177358","definition":"Homo sapiens G protein-coupled receptor 137 (GPR137), transcript variant 5, mRNA.","division":"RefSeq","geneid":"56834","gi":"","length":"1811","nt_position":[],"snippet":"urinary bladder cancer cell growth Erratum:[Biotechnol Appl Biochem. 2023 Aug;70(4):1560. doi: 10.1002/bab.2499. PMID: 37559496] REFERENCE 7 (bases 1 to 1811) AUTHORS Shao,X., Liu,Y., Huang,H., Zhuang,L., Luo,T., Huang,H. and Ge,X. TITLE Down-regulation of G protein-coupled receptor 137 by RNA interference inhibits cell growth of two hepatoma cell lines JOURNAL Cell Biol Int 39 (4), 418-426 (2015) PUBMED 25490967 REMARK GeneRIF: Knockdown of GPR137 in HepG2 cells led to cell cycle arrest at G0/G1 phase and G2/M phase, and induced cell apoptosis, as determined by flow cytometry analysis, which...","source":"Homo sapiens (human)","symbol":"GPR137","synonym":"C11orf4; GPR137A; TM7SF1L1","version":"NM_001177358.2"},{"aa_position":[],"accession":"NR_165394","definition":"Homo sapiens G protein-coupled receptor 137 (GPR137), transcript variant 20, non-coding RNA.","division":"RefSeq","geneid":"56834","gi":"","length":"1666","nt_position":[],"snippet":"urinary bladder cancer cell growth Erratum:[Biotechnol Appl Biochem. 2023 Aug;70(4):1560. doi: 10.1002/bab.2499. PMID: 37559496] REFERENCE 7 (bases 1 to 1666) AUTHORS Shao,X., Liu,Y., Huang,H., Zhuang,L., Luo,T., Huang,H. and Ge,X. TITLE Down-regulation of G protein-coupled receptor 137 by RNA interference inhibits cell growth of two hepatoma cell lines JOURNAL Cell Biol Int 39 (4), 418-426 (2015) PUBMED 25490967 REMARK GeneRIF: Knockdown of GPR137 in HepG2 cells led to cell cycle arrest at G0/G1 phase and G2/M phase, and induced cell apoptosis, as determined by flow cytometry analysis, which...","source":"Homo sapiens (human)","symbol":"GPR137","synonym":"C11orf4; GPR137A; TM7SF1L1","version":"NR_165394.1"},{"aa_position":[],"accession":"NR_134523","definition":"Homo sapiens vesicle transport through interaction with t-SNAREs 1A (VTI1A), transcript variant 6, non-coding RNA.","division":"RefSeq","geneid":"143187","gi":"","length":"2365","nt_position":[],"snippet":"of colorectal adenocarcinomas identifies a recurrent VTI1A-TCF7L2 fusion JOURNAL Nat Genet 43 (10), 964-968 (2011) PUBMED 21892161 REMARK GeneRIF: We found a colorectal carcinoma cell line harboring the fusion gene to be dependent on VTI1A-TCF7L2 for anchorage-independent growth using RNA interference-mediated knockdown. Publication Status: Online-Only REFERENCE 6 (bases 1 to 2365) AUTHORS Flowerdew,S.E. and Burgoyne,R.D. TITLE A VAMP7/Vti1a SNARE complex distinguishes a non-conventional traffic route to the cell surface used by KChIP1 and Kv4 potassium channels JOURNAL Biochem J...","source":"Homo sapiens (human)","symbol":"VTI1A","synonym":"MMDS3; MVti1; Vti1-rp2; VTI1RP2","version":"NR_134523.1"},{"aa_position":[],"accession":"NM_001026383","definition":"Homo sapiens coiled-coil domain containing 7 (CCDC7), transcript variant 2, mRNA.","division":"RefSeq","geneid":"79741","gi":"","length":"1896","nt_position":[],"snippet":"regular exercise JOURNAL Physiol Genomics 36 (2), 79-88 (2009) PUBMED 18984674 REMARK GeneRIF: Observational study of gene-disease association. (HuGE Navigator) REFERENCE 6 (bases 1 to 1896) AUTHORS Wang,C.T., Zhang,P., Wang,Y.S., Ruan,X.Z., Li,Z.Y., Peng,F., Yang,H.S. and Wei,Y.Q. TITLE RNA interference against Biot2, a novel mouse testis-specific gene, inhibits the growth of tumor cells JOURNAL Cell Mol Biol Lett 14 (3), 363-376 (2009) PUBMED 19277478 REFERENCE 7 (bases 1 to 1896) AUTHORS Grupe,A., Li,Y., Rowland,C., Nowotny,P., Hinrichs,A.L., Smemo,S., Kauwe,J.S., Maxwell,T.J., Cherny,S.,...","source":"Homo sapiens (human)","symbol":"CCDC7","synonym":"BIOT2; BioT2-A; BioT2-B; BioT2-C; C10orf68","version":"NM_001026383.3"},{"aa_position":[],"accession":"NM_001170881","definition":"Homo sapiens G protein-coupled receptor 137 (GPR137), transcript variant 1, mRNA.","division":"RefSeq","geneid":"56834","gi":"","length":"1892","nt_position":[],"snippet":"urinary bladder cancer cell growth Erratum:[Biotechnol Appl Biochem. 2023 Aug;70(4):1560. doi: 10.1002/bab.2499. PMID: 37559496] REFERENCE 7 (bases 1 to 1892) AUTHORS Shao,X., Liu,Y., Huang,H., Zhuang,L., Luo,T., Huang,H. and Ge,X. TITLE Down-regulation of G protein-coupled receptor 137 by RNA interference inhibits cell growth of two hepatoma cell lines JOURNAL Cell Biol Int 39 (4), 418-426 (2015) PUBMED 25490967 REMARK GeneRIF: Knockdown of GPR137 in HepG2 cells led to cell cycle arrest at G0/G1 phase and G2/M phase, and induced cell apoptosis, as determined by flow cytometry analysis, which...","source":"Homo sapiens (human)","symbol":"GPR137","synonym":"C11orf4; GPR137A; TM7SF1L1","version":"NM_001170881.2"},{"aa_position":[],"accession":"NM_001378082","definition":"Homo sapiens G protein-coupled receptor 137 (GPR137), transcript variant 12, mRNA.","division":"RefSeq","geneid":"56834","gi":"","length":"1891","nt_position":[],"snippet":"urinary bladder cancer cell growth Erratum:[Biotechnol Appl Biochem. 2023 Aug;70(4):1560. doi: 10.1002/bab.2499. PMID: 37559496] REFERENCE 7 (bases 1 to 1891) AUTHORS Shao,X., Liu,Y., Huang,H., Zhuang,L., Luo,T., Huang,H. and Ge,X. TITLE Down-regulation of G protein-coupled receptor 137 by RNA interference inhibits cell growth of two hepatoma cell lines JOURNAL Cell Biol Int 39 (4), 418-426 (2015) PUBMED 25490967 REMARK GeneRIF: Knockdown of GPR137 in HepG2 cells led to cell cycle arrest at G0/G1 phase and G2/M phase, and induced cell apoptosis, as determined by flow cytometry analysis, which...","source":"Homo sapiens (human)","symbol":"GPR137","synonym":"C11orf4; GPR137A; TM7SF1L1","version":"NM_001378082.1"},{"aa_position":[],"accession":"NM_001378088","definition":"Homo sapiens G protein-coupled receptor 137 (GPR137), transcript variant 18, mRNA.","division":"RefSeq","geneid":"56834","gi":"","length":"1910","nt_position":[],"snippet":"urinary bladder cancer cell growth Erratum:[Biotechnol Appl Biochem. 2023 Aug;70(4):1560. doi: 10.1002/bab.2499. PMID: 37559496] REFERENCE 7 (bases 1 to 1910) AUTHORS Shao,X., Liu,Y., Huang,H., Zhuang,L., Luo,T., Huang,H. and Ge,X. TITLE Down-regulation of G protein-coupled receptor 137 by RNA interference inhibits cell growth of two hepatoma cell lines JOURNAL Cell Biol Int 39 (4), 418-426 (2015) PUBMED 25490967 REMARK GeneRIF: Knockdown of GPR137 in HepG2 cells led to cell cycle arrest at G0/G1 phase and G2/M phase, and induced cell apoptosis, as determined by flow cytometry analysis, which...","source":"Homo sapiens (human)","symbol":"GPR137","synonym":"C11orf4; GPR137A; TM7SF1L1","version":"NM_001378088.1"},{"aa_position":[],"accession":"NM_001378086","definition":"Homo sapiens G protein-coupled receptor 137 (GPR137), transcript variant 16, mRNA.","division":"RefSeq","geneid":"56834","gi":"","length":"1923","nt_position":[],"snippet":"urinary bladder cancer cell growth Erratum:[Biotechnol Appl Biochem. 2023 Aug;70(4):1560. doi: 10.1002/bab.2499. PMID: 37559496] REFERENCE 7 (bases 1 to 1923) AUTHORS Shao,X., Liu,Y., Huang,H., Zhuang,L., Luo,T., Huang,H. and Ge,X. TITLE Down-regulation of G protein-coupled receptor 137 by RNA interference inhibits cell growth of two hepatoma cell lines JOURNAL Cell Biol Int 39 (4), 418-426 (2015) PUBMED 25490967 REMARK GeneRIF: Knockdown of GPR137 in HepG2 cells led to cell cycle arrest at G0/G1 phase and G2/M phase, and induced cell apoptosis, as determined by flow cytometry analysis, which...","source":"Homo sapiens (human)","symbol":"GPR137","synonym":"C11orf4; GPR137A; TM7SF1L1","version":"NM_001378086.1"},{"aa_position":[],"accession":"NM_001378083","definition":"Homo sapiens G protein-coupled receptor 137 (GPR137), transcript variant 13, mRNA.","division":"RefSeq","geneid":"56834","gi":"","length":"1936","nt_position":[],"snippet":"urinary bladder cancer cell growth Erratum:[Biotechnol Appl Biochem. 2023 Aug;70(4):1560. doi: 10.1002/bab.2499. PMID: 37559496] REFERENCE 7 (bases 1 to 1936) AUTHORS Shao,X., Liu,Y., Huang,H., Zhuang,L., Luo,T., Huang,H. and Ge,X. TITLE Down-regulation of G protein-coupled receptor 137 by RNA interference inhibits cell growth of two hepatoma cell lines JOURNAL Cell Biol Int 39 (4), 418-426 (2015) PUBMED 25490967 REMARK GeneRIF: Knockdown of GPR137 in HepG2 cells led to cell cycle arrest at G0/G1 phase and G2/M phase, and induced cell apoptosis, as determined by flow cytometry analysis, which...","source":"Homo sapiens (human)","symbol":"GPR137","synonym":"C11orf4; GPR137A; TM7SF1L1","version":"NM_001378083.1"},{"aa_position":[],"accession":"NM_152551","definition":"Homo sapiens small nuclear ribonucleoprotein U11/U12 subunit 48 (SNRNP48), mRNA.","division":"RefSeq","geneid":"154007","gi":"","length":"4174","nt_position":[],"snippet":"REFERENCE 7 (bases 1 to 4174) AUTHORS Turunen,J.J., Will,C.L., Grote,M., Luhrmann,R. and Frilander,M.J. TITLE The U11-48K protein contacts the 5' splice site of U12-type introns and the U11-59K protein JOURNAL Mol Cell Biol 28 (10), 3548-3560 (2008) PUBMED 18347052 REMARK GeneRIF: RNA interference-induced knockdown of 48K led to reduced cell growth and the inhibition of U12-type splicing, as well as the activation of cryptic, U2-type splice sites, suggesting that 48K plays a critical role in U12-type intron recognition. REFERENCE 8 (bases 1 to 4174) AUTHORS Golas,M.M., Sander,B., Will,C.L.,...","source":"Homo sapiens (human)","symbol":"SNRNP48","synonym":"C6orf151; dJ336K20B.1; dJ512B11.2","version":"NM_152551.4"},{"aa_position":[],"accession":"NM_015975","definition":"Homo sapiens TATA-box binding protein associated factor 9b (TAF9B), mRNA.","division":"RefSeq","geneid":"51616","gi":"","length":"2657","nt_position":[],"snippet":"Nature 434 (7031), 325-337 (2005) PUBMED 15772651 REFERENCE 8 (bases 1 to 2657) AUTHORS Chen,Z. and Manley,J.L. TITLE In vivo functional analysis of the histone 3-like TAF9 and a TAF9-related factor, TAF9L JOURNAL J Biol Chem 278 (37), 35172-35183 (2003) PUBMED 12837753 REMARK GeneRIF: RNA interference experiments suggest that TAF9L is essential for HeLa cell growth and this protein is involved in transcriptional repression. REFERENCE 9 (bases 1 to 2657) AUTHORS Albright,S.R. and Tjian,R. TITLE TAFs revisited: more data reveal new twists and confirm old ideas JOURNAL Gene...","source":"Homo sapiens (human)","symbol":"TAF9B","synonym":"DN-7; DN7; TAF9L; TAFII31L; TFIID-31","version":"NM_015975.5"},{"aa_position":[],"accession":"NM_001354683","definition":"Homo sapiens zinc finger and BTB domain containing 25 (ZBTB25), transcript variant 5, mRNA.","division":"RefSeq","geneid":"7597","gi":"","length":"2922","nt_position":[],"snippet":"differentiation, and lineage-specific transcription factors including ZBTB25 as a novel NF-AT repressor JOURNAL Blood 115 (26), 5376-5384 (2010) PUBMED 20410506 REMARK GeneRIF: ZBTB25 functions as a negative regulator of nuclear factor of activated T cells (NF-AT) activation, such that RNA interference mediated knockdown resulted in enhanced activation of target genes. REFERENCE 8 (bases 1 to 2922) AUTHORS Ravasi,T., Suzuki,H., Cannistraci,C.V., Katayama,S., Bajic,V.B., Tan,K., Akalin,A., Schmeier,S., Kanamori-Katayama,M., Bertin,N., Carninci,P., Daub,C.O., Forrest,A.R., Gough,J., Grimmond,S...","source":"Homo sapiens (human)","symbol":"ZBTB25","synonym":"C14orf51; KUP; ZNF46","version":"NM_001354683.2"},{"aa_position":[],"accession":"NM_001378077","definition":"Homo sapiens G protein-coupled receptor 137 (GPR137), transcript variant 7, mRNA.","division":"RefSeq","geneid":"56834","gi":"","length":"2016","nt_position":[],"snippet":"urinary bladder cancer cell growth Erratum:[Biotechnol Appl Biochem. 2023 Aug;70(4):1560. doi: 10.1002/bab.2499. PMID: 37559496] REFERENCE 7 (bases 1 to 2016) AUTHORS Shao,X., Liu,Y., Huang,H., Zhuang,L., Luo,T., Huang,H. and Ge,X. TITLE Down-regulation of G protein-coupled receptor 137 by RNA interference inhibits cell growth of two hepatoma cell lines JOURNAL Cell Biol Int 39 (4), 418-426 (2015) PUBMED 25490967 REMARK GeneRIF: Knockdown of GPR137 in HepG2 cells led to cell cycle arrest at G0/G1 phase and G2/M phase, and induced cell apoptosis, as determined by flow cytometry analysis, which...","source":"Homo sapiens (human)","symbol":"GPR137","synonym":"C11orf4; GPR137A; TM7SF1L1","version":"NM_001378077.1"},{"aa_position":[],"accession":"NR_165396","definition":"Homo sapiens G protein-coupled receptor 137 (GPR137), transcript variant 22, non-coding RNA.","division":"RefSeq","geneid":"56834","gi":"","length":"1790","nt_position":[],"snippet":"urinary bladder cancer cell growth Erratum:[Biotechnol Appl Biochem. 2023 Aug;70(4):1560. doi: 10.1002/bab.2499. PMID: 37559496] REFERENCE 7 (bases 1 to 1790) AUTHORS Shao,X., Liu,Y., Huang,H., Zhuang,L., Luo,T., Huang,H. and Ge,X. TITLE Down-regulation of G protein-coupled receptor 137 by RNA interference inhibits cell growth of two hepatoma cell lines JOURNAL Cell Biol Int 39 (4), 418-426 (2015) PUBMED 25490967 REMARK GeneRIF: Knockdown of GPR137 in HepG2 cells led to cell cycle arrest at G0/G1 phase and G2/M phase, and induced cell apoptosis, as determined by flow cytometry analysis, which...","source":"Homo sapiens (human)","symbol":"GPR137","synonym":"C11orf4; GPR137A; TM7SF1L1","version":"NR_165396.1"},{"aa_position":[],"accession":"XM_011540884","definition":"PREDICTED: Homo sapiens argonaute RISC component 4 (AGO4), transcript variant X7, mRNA.","division":"RefSeq","geneid":"192670","gi":"","length":"6413","nt_position":[],"snippet":"misc_feature 191..553 /gene=\"AGO4\" /gene_synonym=\"EIF2C4\" /note=\"PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille; Region: PAZ_argonaute_like; cd02846\" /db_xref=\"CDD:239212\" misc_feature order(347..349,392..394,434..436,446..448,500..502, 521..523,527..529) /gene=\"AGO4\" /gene_synonym=\"EIF2C4\" /note=\"nucleic acid-binding interface [nucleotide binding]; other site\" /db_xref=\"CDD:239212\" misc_...","source":"Homo sapiens (human)","symbol":"AGO4","synonym":"EIF2C4","version":"XM_011540884.3"},{"aa_position":[],"accession":"NM_001378079","definition":"Homo sapiens G protein-coupled receptor 137 (GPR137), transcript variant 9, mRNA.","division":"RefSeq","geneid":"56834","gi":"","length":"2042","nt_position":[],"snippet":"urinary bladder cancer cell growth Erratum:[Biotechnol Appl Biochem. 2023 Aug;70(4):1560. doi: 10.1002/bab.2499. PMID: 37559496] REFERENCE 7 (bases 1 to 2042) AUTHORS Shao,X., Liu,Y., Huang,H., Zhuang,L., Luo,T., Huang,H. and Ge,X. TITLE Down-regulation of G protein-coupled receptor 137 by RNA interference inhibits cell growth of two hepatoma cell lines JOURNAL Cell Biol Int 39 (4), 418-426 (2015) PUBMED 25490967 REMARK GeneRIF: Knockdown of GPR137 in HepG2 cells led to cell cycle arrest at G0/G1 phase and G2/M phase, and induced cell apoptosis, as determined by flow cytometry analysis, which...","source":"Homo sapiens (human)","symbol":"GPR137","synonym":"C11orf4; GPR137A; TM7SF1L1","version":"NM_001378079.1"},{"aa_position":[],"accession":"NR_165395","definition":"Homo sapiens G protein-coupled receptor 137 (GPR137), transcript variant 21, non-coding RNA.","division":"RefSeq","geneid":"56834","gi":"","length":"1816","nt_position":[],"snippet":"urinary bladder cancer cell growth Erratum:[Biotechnol Appl Biochem. 2023 Aug;70(4):1560. doi: 10.1002/bab.2499. PMID: 37559496] REFERENCE 7 (bases 1 to 1816) AUTHORS Shao,X., Liu,Y., Huang,H., Zhuang,L., Luo,T., Huang,H. and Ge,X. TITLE Down-regulation of G protein-coupled receptor 137 by RNA interference inhibits cell growth of two hepatoma cell lines JOURNAL Cell Biol Int 39 (4), 418-426 (2015) PUBMED 25490967 REMARK GeneRIF: Knockdown of GPR137 in HepG2 cells led to cell cycle arrest at G0/G1 phase and G2/M phase, and induced cell apoptosis, as determined by flow cytometry analysis, which...","source":"Homo sapiens (human)","symbol":"GPR137","synonym":"C11orf4; GPR137A; TM7SF1L1","version":"NR_165395.1"},{"aa_position":[],"accession":"NM_002263","definition":"Homo sapiens kinesin family member C1 (KIFC1), mRNA.","division":"RefSeq","geneid":"3833","gi":"","length":"2391","nt_position":[],"snippet":"Status: Online-Only REFERENCE 6 (bases 1 to 2391) AUTHORS Zhu,C., Zhao,J., Bibikova,M., Leverson,J.D., Bossy-Wetzel,E., Fan,J.B., Abraham,R.T. and Jiang,W. TITLE Functional analysis of human microtubule-based motor proteins, the kinesins and dyneins, in mitosis/cytokinesis using RNA interference JOURNAL Mol Biol Cell 16 (7), 3187-3199 (2005) PUBMED 15843429 REFERENCE 7 (bases 1 to 2391) AUTHORS Mungall,A.J., Palmer,S.A., Sims,S.K., Edwards,C.A., Ashurst,J.L., Wilming,L., Jones,M.C., Horton,R., Hunt,S.E., Scott,C.E., Gilbert,J.G., Clamp,M.E., Bethel,G., Milne,S., Ainscough,R., Almeida,J.P.,...","source":"Homo sapiens (human)","symbol":"KIFC1","synonym":"HSET; KNSL2","version":"NM_002263.4"},{"aa_position":[],"accession":"NM_145023","definition":"Homo sapiens coiled-coil domain containing 7 (CCDC7), transcript variant 1, mRNA.","division":"RefSeq","geneid":"79741","gi":"","length":"2130","nt_position":[],"snippet":"regular exercise JOURNAL Physiol Genomics 36 (2), 79-88 (2009) PUBMED 18984674 REMARK GeneRIF: Observational study of gene-disease association. (HuGE Navigator) REFERENCE 6 (bases 1 to 2130) AUTHORS Wang,C.T., Zhang,P., Wang,Y.S., Ruan,X.Z., Li,Z.Y., Peng,F., Yang,H.S. and Wei,Y.Q. TITLE RNA interference against Biot2, a novel mouse testis-specific gene, inhibits the growth of tumor cells JOURNAL Cell Mol Biol Lett 14 (3), 363-376 (2009) PUBMED 19277478 REFERENCE 7 (bases 1 to 2130) AUTHORS Grupe,A., Li,Y., Rowland,C., Nowotny,P., Hinrichs,A.L., Smemo,S., Kauwe,J.S., Maxwell,T.J., Cherny,S.,...","source":"Homo sapiens (human)","symbol":"CCDC7","synonym":"BIOT2; BioT2-A; BioT2-B; BioT2-C; C10orf68","version":"NM_145023.6"},{"aa_position":[],"accession":"NR_109826","definition":"Homo sapiens coiled-coil domain containing 7 (CCDC7), transcript variant 3, non-coding RNA.","division":"RefSeq","geneid":"79741","gi":"","length":"1820","nt_position":[],"snippet":"regular exercise JOURNAL Physiol Genomics 36 (2), 79-88 (2009) PUBMED 18984674 REMARK GeneRIF: Observational study of gene-disease association. (HuGE Navigator) REFERENCE 6 (bases 1 to 1820) AUTHORS Wang,C.T., Zhang,P., Wang,Y.S., Ruan,X.Z., Li,Z.Y., Peng,F., Yang,H.S. and Wei,Y.Q. TITLE RNA interference against Biot2, a novel mouse testis-specific gene, inhibits the growth of tumor cells JOURNAL Cell Mol Biol Lett 14 (3), 363-376 (2009) PUBMED 19277478 REFERENCE 7 (bases 1 to 1820) AUTHORS Grupe,A., Li,Y., Rowland,C., Nowotny,P., Hinrichs,A.L., Smemo,S., Kauwe,J.S., Maxwell,T.J., Cherny,S.,...","source":"Homo sapiens (human)","symbol":"CCDC7","synonym":"BIOT2; BioT2-A; BioT2-B; BioT2-C; C10orf68","version":"NR_109826.2"},{"aa_position":[],"accession":"NM_001378085","definition":"Homo sapiens G protein-coupled receptor 137 (GPR137), transcript variant 15, mRNA.","division":"RefSeq","geneid":"56834","gi":"","length":"2047","nt_position":[],"snippet":"urinary bladder cancer cell growth Erratum:[Biotechnol Appl Biochem. 2023 Aug;70(4):1560. doi: 10.1002/bab.2499. PMID: 37559496] REFERENCE 7 (bases 1 to 2047) AUTHORS Shao,X., Liu,Y., Huang,H., Zhuang,L., Luo,T., Huang,H. and Ge,X. TITLE Down-regulation of G protein-coupled receptor 137 by RNA interference inhibits cell growth of two hepatoma cell lines JOURNAL Cell Biol Int 39 (4), 418-426 (2015) PUBMED 25490967 REMARK GeneRIF: Knockdown of GPR137 in HepG2 cells led to cell cycle arrest at G0/G1 phase and G2/M phase, and induced cell apoptosis, as determined by flow cytometry analysis, which...","source":"Homo sapiens (human)","symbol":"GPR137","synonym":"C11orf4; GPR137A; TM7SF1L1","version":"NM_001378085.1"},{"aa_position":[],"accession":"XM_011540883","definition":"PREDICTED: Homo sapiens argonaute RISC component 4 (AGO4), transcript variant X6, mRNA.","division":"RefSeq","geneid":"192670","gi":"","length":"6550","nt_position":[],"snippet":"linker 1 domain; Region: ArgoL1; pfam08699\" /db_xref=\"CDD:462567\" misc_feature 328..690 /gene=\"AGO4\" /gene_synonym=\"EIF2C4\" /note=\"PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille; Region: PAZ_argonaute_like; cd02846\" /db_xref=\"CDD:239212\" misc_feature order(484..486,529..531,571..573,583..585,637..639, 658..660,664..666) /gene=\"AGO4\" /gene_synonym=\"EIF2C4\" /note=\"nucleic acid-binding...","source":"Homo sapiens (human)","symbol":"AGO4","synonym":"EIF2C4","version":"XM_011540883.3"},{"aa_position":[],"accession":"NM_020155","definition":"Homo sapiens G protein-coupled receptor 137 (GPR137), transcript variant 3, mRNA.","division":"RefSeq","geneid":"56834","gi":"","length":"2060","nt_position":[],"snippet":"urinary bladder cancer cell growth Erratum:[Biotechnol Appl Biochem. 2023 Aug;70(4):1560. doi: 10.1002/bab.2499. PMID: 37559496] REFERENCE 7 (bases 1 to 2060) AUTHORS Shao,X., Liu,Y., Huang,H., Zhuang,L., Luo,T., Huang,H. and Ge,X. TITLE Down-regulation of G protein-coupled receptor 137 by RNA interference inhibits cell growth of two hepatoma cell lines JOURNAL Cell Biol Int 39 (4), 418-426 (2015) PUBMED 25490967 REMARK GeneRIF: Knockdown of GPR137 in HepG2 cells led to cell cycle arrest at G0/G1 phase and G2/M phase, and induced cell apoptosis, as determined by flow cytometry analysis, which...","source":"Homo sapiens (human)","symbol":"GPR137","synonym":"C11orf4; GPR137A; TM7SF1L1","version":"NM_020155.4"},{"aa_position":[],"accession":"NM_003215","definition":"Homo sapiens tec protein tyrosine kinase (TEC), mRNA.","division":"RefSeq","geneid":"7006","gi":"","length":"3661","nt_position":[],"snippet":"J.P., Grotwinkel,M., Hentze,N., Mayer,M.P., Will,D.W., Uhrig,U., Lewis,J.D. and Nickel,W. TITLE Small Molecule Inhibitors Targeting Tec Kinase Block Unconventional Secretion of Fibroblast Growth Factor 2 JOURNAL J Biol Chem 291 (34), 17787-17803 (2016) PUBMED 27382052 REMARK GeneRIF: using RNA interference, the identified compounds corroborate the role of Tec kinase in unconventional secretion of FGF2. REFERENCE 5 (bases 1 to 3661) AUTHORS Kleino,I., Jarviluoma,A., Hepojoki,J., Huovila,A.P. and Saksela,K. TITLE Preferred SH3 domain partners of ADAM metalloproteases include shared and ADAM-...","source":"Homo sapiens (human)","symbol":"TEC","synonym":"PSCTK4","version":"NM_003215.3"},{"aa_position":[],"accession":"NM_001170880","definition":"Homo sapiens G protein-coupled receptor 137 (GPR137), transcript variant 2, mRNA.","division":"RefSeq","geneid":"56834","gi":"","length":"2166","nt_position":[],"snippet":"urinary bladder cancer cell growth Erratum:[Biotechnol Appl Biochem. 2023 Aug;70(4):1560. doi: 10.1002/bab.2499. PMID: 37559496] REFERENCE 7 (bases 1 to 2166) AUTHORS Shao,X., Liu,Y., Huang,H., Zhuang,L., Luo,T., Huang,H. and Ge,X. TITLE Down-regulation of G protein-coupled receptor 137 by RNA interference inhibits cell growth of two hepatoma cell lines JOURNAL Cell Biol Int 39 (4), 418-426 (2015) PUBMED 25490967 REMARK GeneRIF: Knockdown of GPR137 in HepG2 cells led to cell cycle arrest at G0/G1 phase and G2/M phase, and induced cell apoptosis, as determined by flow cytometry analysis, which...","source":"Homo sapiens (human)","symbol":"GPR137","synonym":"C11orf4; GPR137A; TM7SF1L1","version":"NM_001170880.2"},{"aa_position":[],"accession":"XM_005270579","definition":"PREDICTED: Homo sapiens argonaute RISC component 4 (AGO4), transcript variant X5, mRNA.","division":"RefSeq","geneid":"192670","gi":"","length":"6757","nt_position":[],"snippet":"linker 1 domain; Region: ArgoL1; pfam08699\" /db_xref=\"CDD:462567\" misc_feature 535..897 /gene=\"AGO4\" /gene_synonym=\"EIF2C4\" /note=\"PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille; Region: PAZ_argonaute_like; cd02846\" /db_xref=\"CDD:239212\" misc_feature order(691..693,736..738,778..780,790..792,844..846, 865..867,871..873) /gene=\"AGO4\" /gene_synonym=\"EIF2C4\" /note=\"nucleic acid-binding...","source":"Homo sapiens (human)","symbol":"AGO4","synonym":"EIF2C4","version":"XM_005270579.4"},{"aa_position":[],"accession":"NM_012154","definition":"Homo sapiens argonaute RISC catalytic component 2 (AGO2), transcript variant 1, mRNA.","division":"RefSeq","geneid":"27161","gi":"","length":"14595","nt_position":[],"snippet":"COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC067931.16 and AC107375.5. On Nov 23, 2018 this sequence version replaced NM_012154.4. Summary: This gene encodes a member of the Argonaute family of proteins which play a role in RNA interference. The encoded protein is highly basic, and contains a PAZ domain and a PIWI domain. It may interact with dicer1 and play a role in short-interfering-RNA-mediated gene silencing. Multiple transcript variants encoding different isoforms have been found for this gene....","source":"Homo sapiens (human)","symbol":"AGO2","synonym":"CASC7; EIF2C2; LESKRES; LINC00980; PPD; Q10","version":"NM_012154.5"},{"aa_position":[],"accession":"NM_001395699","definition":"Homo sapiens dicer 1, ribonuclease III (DICER1), transcript variant 29, mRNA.","division":"RefSeq","geneid":"23405","gi":"","length":"2675","nt_position":[],"snippet":"NCBI staff. The reference sequence was derived from AL356017.3. Summary: This gene encodes a protein possessing an RNA helicase motif containing a DEXH box in its amino terminus and an RNA motif in the carboxy terminus. The encoded protein functions as a ribonuclease and is required by the RNA interference and small temporal RNA (stRNA) pathways to produce the active small RNA component that represses gene expression. This protein also acts as a strong antiviral agent with activity against RNA viruses, including the Zika and SARS-CoV-2 viruses. Alternative splicing results in multiple...","source":"Homo sapiens (human)","symbol":"DICER1","synonym":"aviD; DCR1; Dicer; Dicer1e; GLOW; HERNA; K12H4.8-LIKE; MNG1; RMSE2","version":"NM_001395699.1"},{"aa_position":[],"accession":"XM_005270578","definition":"PREDICTED: Homo sapiens argonaute RISC component 4 (AGO4), transcript variant X4, mRNA.","division":"RefSeq","geneid":"192670","gi":"","length":"6940","nt_position":[],"snippet":"linker 1 domain; Region: ArgoL1; pfam08699\" /db_xref=\"CDD:462567\" misc_feature 718..1080 /gene=\"AGO4\" /gene_synonym=\"EIF2C4\" /note=\"PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille; Region: PAZ_argonaute_like; cd02846\" /db_xref=\"CDD:239212\" misc_feature order(874..876,919..921,961..963,973..975,1027..1029, 1048..1050,1054..1056) /gene=\"AGO4\" /gene_synonym=\"EIF2C4\" /note=\"nucleic acid-binding...","source":"Homo sapiens (human)","symbol":"AGO4","synonym":"EIF2C4","version":"XM_005270578.4"},{"aa_position":[],"accession":"NM_018323","definition":"Homo sapiens phosphatidylinositol 4-kinase type 2 beta (PI4K2B), transcript variant 1, mRNA.","division":"RefSeq","geneid":"55300","gi":"","length":"3594","nt_position":[],"snippet":"J., White,I.J., Al-Shawi,R., Simons,J.P., Mossinger,J., Haucke,V. and Cutler,D.F. TITLE Type II PI4-kinases control Weibel-Palade body biogenesis and von Willebrand factor structure in human endothelial cells JOURNAL J Cell Sci 129 (10), 2096-2105 (2016) PUBMED 27068535 REMARK GeneRIF: RNA interference of the type II phosphatidylinositol 4-kinases PI4KIIa and PI4KIIa in primary human endothelial cells leads to formation of an increased proportion of short WPB with perturbed packing of VWF, as exemplified by increased exposure of antibody-binding sites. REFERENCE 2 (bases 1 to 3594) AUTHORS...","source":"Homo sapiens (human)","symbol":"PI4K2B","synonym":"PI4KIIB; PIK42B","version":"NM_018323.4"},{"aa_position":[],"accession":"NM_001363260","definition":"Homo sapiens cilia and flagella associated protein 418 (CFAP418), transcript variant 2, mRNA.","division":"RefSeq","geneid":"157657","gi":"","length":"3244","nt_position":[],"snippet":"PUBMED 36233334 REMARK GeneRIF: Interactions between C8orf37 and FAM161A, Two Ciliary Proteins Essential for Photoreceptor Survival. Publication Status: Online-Only REFERENCE 3 (bases 1 to 3244) AUTHORS Fang,Z., Zhao,Z., Eapen,V. and Clarke,R.A. TITLE siRNA Mediate RNA Interference Concordant with Early On-Target Transient Transcriptional Interference JOURNAL Genes (Basel) 12 (8), 1290 (2021) PUBMED 34440463 REMARK Publication Status: Online-Only REFERENCE 4 (bases 1 to 3244) AUTHORS Sharif,A.S., Yu,D., Loertscher,S., Austin,R., Nguyen,K., Mathur,P.D., Clark,A.M., Zou,J., Lobanova,E.S.,...","source":"Homo sapiens (human)","symbol":"CFAP418","synonym":"BBS21; C8orf37; CORD16; FAP418; MOT25; RP64; smalltalk","version":"NM_001363260.1"},{"aa_position":[],"accession":"NR_165397","definition":"Homo sapiens G protein-coupled receptor 137 (GPR137), transcript variant 23, non-coding RNA.","division":"RefSeq","geneid":"56834","gi":"","length":"2015","nt_position":[],"snippet":"urinary bladder cancer cell growth Erratum:[Biotechnol Appl Biochem. 2023 Aug;70(4):1560. doi: 10.1002/bab.2499. PMID: 37559496] REFERENCE 7 (bases 1 to 2015) AUTHORS Shao,X., Liu,Y., Huang,H., Zhuang,L., Luo,T., Huang,H. and Ge,X. TITLE Down-regulation of G protein-coupled receptor 137 by RNA interference inhibits cell growth of two hepatoma cell lines JOURNAL Cell Biol Int 39 (4), 418-426 (2015) PUBMED 25490967 REMARK GeneRIF: Knockdown of GPR137 in HepG2 cells led to cell cycle arrest at G0/G1 phase and G2/M phase, and induced cell apoptosis, as determined by flow cytometry analysis, which...","source":"Homo sapiens (human)","symbol":"GPR137","synonym":"C11orf4; GPR137A; TM7SF1L1","version":"NR_165397.1"},{"aa_position":[],"accession":"NM_005857","definition":"Homo sapiens zinc metallopeptidase STE24 (ZMPSTE24), mRNA.","division":"RefSeq","geneid":"10269","gi":"","length":"2975","nt_position":[],"snippet":"AUTHORS Gruber,J., Lampe,T., Osborn,M. and Weber,K. TITLE RNAi of FACE1 protease results in growth inhibition of human cells expressing lamin A: implications for Hutchinson-Gilford progeria syndrome JOURNAL J Cell Sci 118 (Pt 4), 689-696 (2005) PUBMED 15671064 REMARK GeneRIF: RNA interference of FACE1 protease results in a halt of cell division and accumulation of prelamin A. REFERENCE 5 (bases 1 to 2975) AUTHORS Navarro,C.L., De Sandre-Giovannoli,A., Bernard,R., Boccaccio,I., Boyer,A., Genevieve,D., Hadj-Rabia,S., Gaudy-Marqueste,C., Smitt,H.S., Vabres,P., Faivre,L., Verloes,A., Van...","source":"Homo sapiens (human)","symbol":"ZMPSTE24","synonym":"FACE-1; FACE1; HGPS; PRO1; RSDM1; STE24; Ste24p","version":"NM_005857.5"},{"aa_position":[],"accession":"NM_174909","definition":"Homo sapiens transmembrane protein 167A (TMEM167A), mRNA.","division":"RefSeq","geneid":"153339","gi":"","length":"4528","nt_position":[],"snippet":"sCOMP and uCTX-II with genome wide significance JOURNAL J Med Genet 51 (9), 596-604 (2014) PUBMED 25057126 REFERENCE 5 (bases 1 to 4528) AUTHORS Wendler,F., Gillingham,A.K., Sinka,R., Rosa-Ferreira,C., Gordon,D.E., Franch-Marro,X., Peden,A.A., Vincent,J.P. and Munro,S. TITLE A genome-wide RNA interference screen identifies two novel components of the metazoan secretory pathway JOURNAL EMBO J 29 (2), 304-314 (2010) PUBMED 19942856 REFERENCE 6 (bases 1 to 4528) AUTHORS Moretto,A., Bertolazzi,M., Capodicasa,E., Peraica,M., Richardson,R.J., Scapellato,M.L. and Lotti,M. TITLE Phenylmethanesulfonyl...","source":"Homo sapiens (human)","symbol":"TMEM167A","synonym":"kish; TMEM167","version":"NM_174909.5"},{"aa_position":[],"accession":"NM_177965","definition":"Homo sapiens cilia and flagella associated protein 418 (CFAP418), transcript variant 1, mRNA.","division":"RefSeq","geneid":"157657","gi":"","length":"3340","nt_position":[],"snippet":"PUBMED 36233334 REMARK GeneRIF: Interactions between C8orf37 and FAM161A, Two Ciliary Proteins Essential for Photoreceptor Survival. Publication Status: Online-Only REFERENCE 3 (bases 1 to 3340) AUTHORS Fang,Z., Zhao,Z., Eapen,V. and Clarke,R.A. TITLE siRNA Mediate RNA Interference Concordant with Early On-Target Transient Transcriptional Interference JOURNAL Genes (Basel) 12 (8), 1290 (2021) PUBMED 34440463 REMARK Publication Status: Online-Only REFERENCE 4 (bases 1 to 3340) AUTHORS Sharif,A.S., Yu,D., Loertscher,S., Austin,R., Nguyen,K., Mathur,P.D., Clark,A.M., Zou,J., Lobanova,E.S.,...","source":"Homo sapiens (human)","symbol":"CFAP418","synonym":"BBS21; C8orf37; CORD16; FAP418; MOT25; RP64; smalltalk","version":"NM_177965.4"},{"aa_position":[],"accession":"NR_144633","definition":"Homo sapiens phosphatidylinositol 4-kinase type 2 beta (PI4K2B), transcript variant 2, non-coding RNA.","division":"RefSeq","geneid":"55300","gi":"","length":"3609","nt_position":[],"snippet":"Vizi J, White IJ, Al-Shawi R, Simons JP, Mossinger J, Haucke V and Cutler DF. TITLE Type II PI4-kinases control Weibel-Palade body biogenesis and von Willebrand factor structure in human endothelial cells JOURNAL J. Cell. Sci. 129 (10), 2096-2105 (2016) PUBMED 27068535 REMARK GeneRIF: RNA interference of the type II phosphatidylinositol 4-kinases PI4KIIa and PI4KIIa in primary human endothelial cells leads to formation of an increased proportion of short WPB with perturbed packing of VWF, as exemplified by increased exposure of antibody-binding sites. REFERENCE 2 (bases 1 to 3609) AUTHORS...","source":"Homo sapiens (human)","symbol":"PI4K2B","synonym":"PI4KIIB; PIK42B","version":"NR_144633.2"},{"aa_position":[],"accession":"NM_001130047","definition":"Homo sapiens tubulin folding cofactor E like (TBCEL), transcript variant 2, mRNA.","division":"RefSeq","geneid":"219899","gi":"","length":"5025","nt_position":[],"snippet":"Sellin,M.E., Holmfeldt,P., Stenmark,S. and Gullberg,M. TITLE Op18/Stathmin counteracts the activity of overexpressed tubulin-disrupting proteins in a human leukemia cell line JOURNAL Exp Cell Res 314 (6), 1367-1377 (2008) PUBMED 18262179 REMARK GeneRIF: Depletion of Op18 by means of RNA interference increased the susceptibility of tubulin to TBCE or E-like mediated disruption, while overexpressed Op18 exerted a tubulin-protective effect. REFERENCE 4 (bases 1 to 5025) AUTHORS Bartolini,F., Tian,G., Piehl,M., Cassimeris,L., Lewis,S.A. and Cowan,N.J. TITLE Identification of a novel tubulin-...","source":"Homo sapiens (human)","symbol":"TBCEL","synonym":"El; LRRC35","version":"NM_001130047.3"},{"aa_position":[],"accession":"NM_001099293","definition":"Homo sapiens kinesin family member 4B (KIF4B), mRNA.","division":"RefSeq","geneid":"285643","gi":"","length":"4387","nt_position":[],"snippet":"e357 (2005) PUBMED 16201836 REFERENCE 2 (bases 1 to 4387) AUTHORS Zhu,C., Zhao,J., Bibikova,M., Leverson,J.D., Bossy-Wetzel,E., Fan,J.B., Abraham,R.T. and Jiang,W. TITLE Functional analysis of human microtubule-based motor proteins, the kinesins and dyneins, in mitosis/cytokinesis using RNA interference JOURNAL Mol Biol Cell 16 (7), 3187-3199 (2005) PUBMED 15843429 REFERENCE 3 (bases 1 to 4387) AUTHORS Oh,S., Hahn,H., Torrey,T.A., Shin,H., Choi,W., Lee,Y.M., Morse,H.C. and Kim,W. TITLE Identification of the human homologue of mouse KIF4, a kinesin superfamily motor protein JOURNAL Biochim...","source":"Homo sapiens (human)","symbol":"KIF4B","synonym":"","version":"NM_001099293.3"},{"aa_position":[],"accession":"NM_152715","definition":"Homo sapiens tubulin folding cofactor E like (TBCEL), transcript variant 1, mRNA.","division":"RefSeq","geneid":"219899","gi":"","length":"5162","nt_position":[],"snippet":"Sellin,M.E., Holmfeldt,P., Stenmark,S. and Gullberg,M. TITLE Op18/Stathmin counteracts the activity of overexpressed tubulin-disrupting proteins in a human leukemia cell line JOURNAL Exp Cell Res 314 (6), 1367-1377 (2008) PUBMED 18262179 REMARK GeneRIF: Depletion of Op18 by means of RNA interference increased the susceptibility of tubulin to TBCE or E-like mediated disruption, while overexpressed Op18 exerted a tubulin-protective effect. REFERENCE 4 (bases 1 to 5162) AUTHORS Bartolini,F., Tian,G., Piehl,M., Cassimeris,L., Lewis,S.A. and Cowan,N.J. TITLE Identification of a novel tubulin-...","source":"Homo sapiens (human)","symbol":"TBCEL","synonym":"El; LRRC35","version":"NM_152715.5"},{"aa_position":[],"accession":"NM_001363644","definition":"Homo sapiens tubulin folding cofactor E like (TBCEL), transcript variant 3, mRNA.","division":"RefSeq","geneid":"219899","gi":"","length":"5270","nt_position":[],"snippet":"Sellin,M.E., Holmfeldt,P., Stenmark,S. and Gullberg,M. TITLE Op18/Stathmin counteracts the activity of overexpressed tubulin-disrupting proteins in a human leukemia cell line JOURNAL Exp Cell Res 314 (6), 1367-1377 (2008) PUBMED 18262179 REMARK GeneRIF: Depletion of Op18 by means of RNA interference increased the susceptibility of tubulin to TBCE or E-like mediated disruption, while overexpressed Op18 exerted a tubulin-protective effect. REFERENCE 4 (bases 1 to 5270) AUTHORS Bartolini,F., Tian,G., Piehl,M., Cassimeris,L., Lewis,S.A. and Cowan,N.J. TITLE Identification of a novel tubulin-...","source":"Homo sapiens (human)","symbol":"TBCEL","synonym":"El; LRRC35","version":"NM_001363644.2"},{"aa_position":[],"accession":"NM_001291446","definition":"Homo sapiens spalt like transcription factor 2 (SALL2), transcript variant 2, mRNA.","division":"RefSeq","geneid":"6297","gi":"","length":"3855","nt_position":[],"snippet":"function. REFERENCE 3 (bases 1 to 3855) AUTHORS Miao,F., Zhang,X., Cao,Y., Wang,Y. and Zhang,X. TITLE Effect of siRNA-silencing of SALL2 gene on growth, migration and invasion of human ovarian carcinoma A2780 cells JOURNAL BMC Cancer 17 (1), 838 (2017) PUBMED 29228922 REMARK GeneRIF: Using RNA interference, the role of Spalt-like gene-2 (SALL2) was investigated in human ovarian carcinoma (OC) A2780 cells. Found downregulation of SALL2 promoted growth of the OC cell line. Publication Status: Online-Only REFERENCE 4 (bases 1 to 3855) AUTHORS Hermosilla,V.E., Hepp,M.I., Escobar,D., Farkas,C.,...","source":"Homo sapiens (human)","symbol":"SALL2","synonym":"COLB; HSAL2; p150(Sal2); Sal-2; ZNF795","version":"NM_001291446.2"},{"aa_position":[],"accession":"NM_001291447","definition":"Homo sapiens spalt like transcription factor 2 (SALL2), transcript variant 3, mRNA.","division":"RefSeq","geneid":"6297","gi":"","length":"3868","nt_position":[],"snippet":"function. REFERENCE 3 (bases 1 to 3868) AUTHORS Miao,F., Zhang,X., Cao,Y., Wang,Y. and Zhang,X. TITLE Effect of siRNA-silencing of SALL2 gene on growth, migration and invasion of human ovarian carcinoma A2780 cells JOURNAL BMC Cancer 17 (1), 838 (2017) PUBMED 29228922 REMARK GeneRIF: Using RNA interference, the role of Spalt-like gene-2 (SALL2) was investigated in human ovarian carcinoma (OC) A2780 cells. Found downregulation of SALL2 promoted growth of the OC cell line. Publication Status: Online-Only REFERENCE 4 (bases 1 to 3868) AUTHORS Hermosilla,V.E., Hepp,M.I., Escobar,D., Farkas,C.,...","source":"Homo sapiens (human)","symbol":"SALL2","synonym":"COLB; HSAL2; p150(Sal2); Sal-2; ZNF795","version":"NM_001291447.2"},{"aa_position":[],"accession":"NM_001394786","definition":"Homo sapiens nuclear factor of activated T cells 2 interacting protein (NFATC2IP), transcript variant 4, mRNA.","division":"RefSeq","geneid":"84901","gi":"","length":"4033","nt_position":[],"snippet":"differentiation, and lineage-specific transcription factors including ZBTB25 as a novel NF-AT repressor JOURNAL Blood 115 (26), 5376-5384 (2010) PUBMED 20410506 REMARK GeneRIF: ZBTB25 functions as a negative regulator of nuclear factor of activated T cells (NF-AT) activation, such that RNA interference mediated knockdown resulted in enhanced activation of target genes. REFERENCE 8 (bases 1 to 4033) AUTHORS Beausoleil,S.A., Villen,J., Gerber,S.A., Rush,J. and Gygi,S.P. TITLE A probability-based approach for high-throughput protein phosphorylation analysis and site localization JOURNAL Nat...","source":"Homo sapiens (human)","symbol":"NFATC2IP","synonym":"ESC2; NIP45; RAD60","version":"NM_001394786.1"},{"aa_position":[],"accession":"NM_001304507","definition":"Homo sapiens zinc finger and BTB domain containing 25 (ZBTB25), transcript variant 1, mRNA.","division":"RefSeq","geneid":"7597","gi":"","length":"3324","nt_position":[],"snippet":"differentiation, and lineage-specific transcription factors including ZBTB25 as a novel NF-AT repressor JOURNAL Blood 115 (26), 5376-5384 (2010) PUBMED 20410506 REMARK GeneRIF: ZBTB25 functions as a negative regulator of nuclear factor of activated T cells (NF-AT) activation, such that RNA interference mediated knockdown resulted in enhanced activation of target genes. REFERENCE 8 (bases 1 to 3324) AUTHORS Ravasi,T., Suzuki,H., Cannistraci,C.V., Katayama,S., Bajic,V.B., Tan,K., Akalin,A., Schmeier,S., Kanamori-Katayama,M., Bertin,N., Carninci,P., Daub,C.O., Forrest,A.R., Gough,J., Grimmond,S...","source":"Homo sapiens (human)","symbol":"ZBTB25","synonym":"C14orf51; KUP; ZNF46","version":"NM_001304507.1"},{"aa_position":[],"accession":"NM_001007102","definition":"Homo sapiens L3MBTL histone methyl-lysine binding protein 3 (L3MBTL3), transcript variant 2, mRNA.","division":"RefSeq","geneid":"84456","gi":"","length":"4131","nt_position":[],"snippet":"Kiemeney,L.A., Kong,A., Thorsteinsdottir,U. and Stefansson,K. TITLE Many sequence variants affecting diversity of adult human height JOURNAL Nat Genet 40 (5), 609-615 (2008) PUBMED 18391951 REFERENCE 9 (bases 1 to 4131) AUTHORS Lu,J., Ruhf,M.L., Perrimon,N. and Leder,P. TITLE A genome-wide RNA interference screen identifies putative chromatin regulators essential for E2F repression JOURNAL Proc Natl Acad Sci U S A 104 (22), 9381-9386 (2007) PUBMED 17517653 REFERENCE 10 (bases 1 to 4131) AUTHORS Arai,S. and Miyazaki,T. TITLE Impaired maturation of myeloid progenitors in mice lacking novel...","source":"Homo sapiens (human)","symbol":"L3MBTL3","synonym":"MBT-1; MBT1","version":"NM_001007102.4"},{"aa_position":[],"accession":"NM_001346550","definition":"Homo sapiens L3MBTL histone methyl-lysine binding protein 3 (L3MBTL3), transcript variant 3, mRNA.","division":"RefSeq","geneid":"84456","gi":"","length":"4117","nt_position":[],"snippet":"Kiemeney,L.A., Kong,A., Thorsteinsdottir,U. and Stefansson,K. TITLE Many sequence variants affecting diversity of adult human height JOURNAL Nat Genet 40 (5), 609-615 (2008) PUBMED 18391951 REFERENCE 9 (bases 1 to 4117) AUTHORS Lu,J., Ruhf,M.L., Perrimon,N. and Leder,P. TITLE A genome-wide RNA interference screen identifies putative chromatin regulators essential for E2F repression JOURNAL Proc Natl Acad Sci U S A 104 (22), 9381-9386 (2007) PUBMED 17517653 REFERENCE 10 (bases 1 to 4117) AUTHORS Arai,S. and Miyazaki,T. TITLE Impaired maturation of myeloid progenitors in mice lacking novel...","source":"Homo sapiens (human)","symbol":"L3MBTL3","synonym":"MBT-1; MBT1","version":"NM_001346550.2"},{"aa_position":[],"accession":"NM_145206","definition":"Homo sapiens vesicle transport through interaction with t-SNAREs 1A (VTI1A), transcript variant 2, mRNA.","division":"RefSeq","geneid":"143187","gi":"","length":"4174","nt_position":[],"snippet":"of colorectal adenocarcinomas identifies a recurrent VTI1A-TCF7L2 fusion JOURNAL Nat Genet 43 (10), 964-968 (2011) PUBMED 21892161 REMARK GeneRIF: We found a colorectal carcinoma cell line harboring the fusion gene to be dependent on VTI1A-TCF7L2 for anchorage-independent growth using RNA interference-mediated knockdown. Publication Status: Online-Only REFERENCE 6 (bases 1 to 4174) AUTHORS Flowerdew,S.E. and Burgoyne,R.D. TITLE A VAMP7/Vti1a SNARE complex distinguishes a non-conventional traffic route to the cell surface used by KChIP1 and Kv4 potassium channels JOURNAL Biochem J...","source":"Homo sapiens (human)","symbol":"VTI1A","synonym":"MMDS3; MVti1; Vti1-rp2; VTI1RP2","version":"NM_145206.4"},{"aa_position":[],"accession":"NM_001304351","definition":"Homo sapiens ADAM metallopeptidase domain 28 (ADAM28), transcript variant 4, mRNA.","division":"RefSeq","geneid":"10863","gi":"","length":"6956","nt_position":[],"snippet":"TITLE ADAM28: Another ambivalent protease in cancer JOURNAL Cancer Lett 494, 18-26 (2020) PUBMED 32861707 REMARK GeneRIF: ADAM28: Another ambivalent protease in cancer. Review article REFERENCE 4 (bases 1 to 6956) AUTHORS Zhao,Z., Qiu,H.Y., Fu,L. and Li,J. TITLE [Construction of ADAM28 shRNA interference vector and its inhibitory effect on human periodontal ligament stem cells] JOURNAL Shanghai Kou Qiang Yi Xue 29 (5), 476-481 (2020) PUBMED 33543212 REMARK GeneRIF: [Construction of ADAM28 shRNA interference vector and its inhibitory effect on human periodontal ligament stem cells]. REFERENCE...","source":"Homo sapiens (human)","symbol":"ADAM28","synonym":"ADAM 28; eMDC II; eMDCII; MDC-L; MDCL","version":"NM_001304351.2"},{"aa_position":[],"accession":"NM_001318205","definition":"Homo sapiens vesicle transport through interaction with t-SNAREs 1A (VTI1A), transcript variant 3, mRNA.","division":"RefSeq","geneid":"143187","gi":"","length":"4185","nt_position":[],"snippet":"of colorectal adenocarcinomas identifies a recurrent VTI1A-TCF7L2 fusion JOURNAL Nat Genet 43 (10), 964-968 (2011) PUBMED 21892161 REMARK GeneRIF: We found a colorectal carcinoma cell line harboring the fusion gene to be dependent on VTI1A-TCF7L2 for anchorage-independent growth using RNA interference-mediated knockdown. Publication Status: Online-Only REFERENCE 6 (bases 1 to 4185) AUTHORS Flowerdew,S.E. and Burgoyne,R.D. TITLE A VAMP7/Vti1a SNARE complex distinguishes a non-conventional traffic route to the cell surface used by KChIP1 and Kv4 potassium channels JOURNAL Biochem J...","source":"Homo sapiens (human)","symbol":"VTI1A","synonym":"MMDS3; MVti1; Vti1-rp2; VTI1RP2","version":"NM_001318205.2"},{"aa_position":[],"accession":"NM_001318203","definition":"Homo sapiens vesicle transport through interaction with t-SNAREs 1A (VTI1A), transcript variant 1, mRNA.","division":"RefSeq","geneid":"143187","gi":"","length":"4195","nt_position":[],"snippet":"of colorectal adenocarcinomas identifies a recurrent VTI1A-TCF7L2 fusion JOURNAL Nat Genet 43 (10), 964-968 (2011) PUBMED 21892161 REMARK GeneRIF: We found a colorectal carcinoma cell line harboring the fusion gene to be dependent on VTI1A-TCF7L2 for anchorage-independent growth using RNA interference-mediated knockdown. Publication Status: Online-Only REFERENCE 6 (bases 1 to 4195) AUTHORS Flowerdew,S.E. and Burgoyne,R.D. TITLE A VAMP7/Vti1a SNARE complex distinguishes a non-conventional traffic route to the cell surface used by KChIP1 and Kv4 potassium channels JOURNAL Biochem J...","source":"Homo sapiens (human)","symbol":"VTI1A","synonym":"MMDS3; MVti1; Vti1-rp2; VTI1RP2","version":"NM_001318203.2"},{"aa_position":[],"accession":"NM_001365712","definition":"Homo sapiens vesicle transport through interaction with t-SNAREs 1A (VTI1A), transcript variant 9, mRNA.","division":"RefSeq","geneid":"143187","gi":"","length":"4206","nt_position":[],"snippet":"of colorectal adenocarcinomas identifies a recurrent VTI1A-TCF7L2 fusion JOURNAL Nat Genet 43 (10), 964-968 (2011) PUBMED 21892161 REMARK GeneRIF: We found a colorectal carcinoma cell line harboring the fusion gene to be dependent on VTI1A-TCF7L2 for anchorage-independent growth using RNA interference-mediated knockdown. Publication Status: Online-Only REFERENCE 6 (bases 1 to 4206) AUTHORS Flowerdew,S.E. and Burgoyne,R.D. TITLE A VAMP7/Vti1a SNARE complex distinguishes a non-conventional traffic route to the cell surface used by KChIP1 and Kv4 potassium channels JOURNAL Biochem J...","source":"Homo sapiens (human)","symbol":"VTI1A","synonym":"MMDS3; MVti1; Vti1-rp2; VTI1RP2","version":"NM_001365712.1"},{"aa_position":[],"accession":"NM_014265","definition":"Homo sapiens ADAM metallopeptidase domain 28 (ADAM28), transcript variant 1, mRNA.","division":"RefSeq","geneid":"10863","gi":"","length":"7019","nt_position":[],"snippet":"TITLE ADAM28: Another ambivalent protease in cancer JOURNAL Cancer Lett 494, 18-26 (2020) PUBMED 32861707 REMARK GeneRIF: ADAM28: Another ambivalent protease in cancer. Review article REFERENCE 4 (bases 1 to 7019) AUTHORS Zhao,Z., Qiu,H.Y., Fu,L. and Li,J. TITLE [Construction of ADAM28 shRNA interference vector and its inhibitory effect on human periodontal ligament stem cells] JOURNAL Shanghai Kou Qiang Yi Xue 29 (5), 476-481 (2020) PUBMED 33543212 REMARK GeneRIF: [Construction of ADAM28 shRNA interference vector and its inhibitory effect on human periodontal ligament stem cells]. REFERENCE...","source":"Homo sapiens (human)","symbol":"ADAM28","synonym":"ADAM 28; eMDC II; eMDCII; MDC-L; MDCL","version":"NM_014265.6"},{"aa_position":[],"accession":"NM_032438","definition":"Homo sapiens L3MBTL histone methyl-lysine binding protein 3 (L3MBTL3), transcript variant 1, mRNA.","division":"RefSeq","geneid":"84456","gi":"","length":"4206","nt_position":[],"snippet":"Kiemeney,L.A., Kong,A., Thorsteinsdottir,U. and Stefansson,K. TITLE Many sequence variants affecting diversity of adult human height JOURNAL Nat Genet 40 (5), 609-615 (2008) PUBMED 18391951 REFERENCE 9 (bases 1 to 4206) AUTHORS Lu,J., Ruhf,M.L., Perrimon,N. and Leder,P. TITLE A genome-wide RNA interference screen identifies putative chromatin regulators essential for E2F repression JOURNAL Proc Natl Acad Sci U S A 104 (22), 9381-9386 (2007) PUBMED 17517653 REFERENCE 10 (bases 1 to 4206) AUTHORS Arai,S. and Miyazaki,T. TITLE Impaired maturation of myeloid progenitors in mice lacking novel...","source":"Homo sapiens (human)","symbol":"L3MBTL3","synonym":"MBT-1; MBT1","version":"NM_032438.4"},{"aa_position":[],"accession":"NM_001317123","definition":"Homo sapiens argonaute RISC component 1 (AGO1), transcript variant 2, mRNA.","division":"RefSeq","geneid":"26523","gi":"","length":"13617","nt_position":[],"snippet":"sequence was derived from AL139286.13, AK001622.1, AK314148.1, AF093097.1 and CR936823.1. On Aug 13, 2020 this sequence version replaced NM_001317123.1. Summary: This gene encodes a member of the argonaute family of proteins, which associate with small RNAs and have important roles in RNA interference (RNAi) and RNA silencing. This protein binds to microRNAs (miRNAs) or small interfering RNAs (siRNAs) and represses translation of mRNAs that are complementary to them. It is also involved in transcriptional gene silencing (TGS) of promoter regions that are complementary to bound short antigene...","source":"Homo sapiens (human)","symbol":"AGO1","synonym":"EIF2C; EIF2C1; GERP95; hAgo1; NEDLBAS; Q99","version":"NM_001317123.2"},{"aa_position":[],"accession":"NM_145695","definition":"Homo sapiens diacylglycerol kinase beta (DGKB), transcript variant 2, mRNA.","division":"RefSeq","geneid":"1607","gi":"","length":"3360","nt_position":[],"snippet":"AUTHORS Peiris,H., Park,S., Louis,S., Gu,X., Lam,J.Y., Asplund,O., Ippolito,G.C., Bottino,R., Groop,L., Tucker,H. and Kim,S.K. TITLE Discovering human diabetes-risk gene function with genetics and physiological assays JOURNAL Nat Commun 9 (1), 3855 (2018) PUBMED 30242153 REMARK GeneRIF: RNA interference-mediated knockdown of the Drosophila ortholog of DGKB in insulin-producing cells, a model for mammalian beta cells, conferred increased insulin output. Publication Status: Online-Only REFERENCE 4 (bases 1 to 3360) AUTHORS Tarnowski,M., Malinowski,D., Pawlak,K., Dziedziejko,V., Safranow,K. and...","source":"Homo sapiens (human)","symbol":"DGKB","synonym":"DAGK2; DGK; DGK-BETA","version":"NM_145695.2"},{"aa_position":[],"accession":"NM_001346551","definition":"Homo sapiens L3MBTL histone methyl-lysine binding protein 3 (L3MBTL3), transcript variant 4, mRNA.","division":"RefSeq","geneid":"84456","gi":"","length":"4225","nt_position":[],"snippet":"Kiemeney,L.A., Kong,A., Thorsteinsdottir,U. and Stefansson,K. TITLE Many sequence variants affecting diversity of adult human height JOURNAL Nat Genet 40 (5), 609-615 (2008) PUBMED 18391951 REFERENCE 9 (bases 1 to 4225) AUTHORS Lu,J., Ruhf,M.L., Perrimon,N. and Leder,P. TITLE A genome-wide RNA interference screen identifies putative chromatin regulators essential for E2F repression JOURNAL Proc Natl Acad Sci U S A 104 (22), 9381-9386 (2007) PUBMED 17517653 REFERENCE 10 (bases 1 to 4225) AUTHORS Arai,S. and Miyazaki,T. TITLE Impaired maturation of myeloid progenitors in mice lacking novel...","source":"Homo sapiens (human)","symbol":"L3MBTL3","synonym":"MBT-1; MBT1","version":"NM_001346551.2"},{"aa_position":[],"accession":"NM_001080472","definition":"Homo sapiens fat storage inducing transmembrane protein 2 (FITM2), mRNA.","division":"RefSeq","geneid":"128486","gi":"","length":"4628","nt_position":[],"snippet":"sensory neuropathy JOURNAL Dis Model Mech 10 (2), 105-118 (2017) PUBMED 28067622 REMARK GeneRIF: In order to obtain independent evidence for the involvement of FITM2 in the human pathology, downregulation of the single Fitm ortholog, CG10671, in Drosophila melanogaster was pursued using RNA interference. REFERENCE 9 (bases 1 to 4628) AUTHORS Bai,S.W., Herrera-Abreu,M.T., Rohn,J.L., Racine,V., Tajadura,V., Suryavanshi,N., Bechtel,S., Wiemann,S., Baum,B. and Ridley,A.J. TITLE Identification and characterization of a set of conserved and new regulators of cytoskeletal organization, cell...","source":"Homo sapiens (human)","symbol":"FITM2","synonym":"C20orf142; dJ881L22.2; Fit2; SIDDIS","version":"NM_001080472.4"},{"aa_position":[],"accession":"NM_001317122","definition":"Homo sapiens argonaute RISC component 1 (AGO1), transcript variant 1, mRNA.","division":"RefSeq","geneid":"26523","gi":"","length":"13712","nt_position":[],"snippet":"was derived from HY052874.1, BC063275.1, AK314148.1, AF093097.1, CR936823.1 and AL139286.13. On Aug 13, 2020 this sequence version replaced NM_001317122.1. Summary: This gene encodes a member of the argonaute family of proteins, which associate with small RNAs and have important roles in RNA interference (RNAi) and RNA silencing. This protein binds to microRNAs (miRNAs) or small interfering RNAs (siRNAs) and represses translation of mRNAs that are complementary to them. It is also involved in transcriptional gene silencing (TGS) of promoter regions that are complementary to bound short...","source":"Homo sapiens (human)","symbol":"AGO1","synonym":"EIF2C; EIF2C1; GERP95; hAgo1; NEDLBAS; Q99","version":"NM_001317122.2"},{"aa_position":[],"accession":"NM_001164623","definition":"Homo sapiens argonaute RISC catalytic component 2 (AGO2), transcript variant 2, mRNA.","division":"RefSeq","geneid":"27161","gi":"","length":"14493","nt_position":[],"snippet":"REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC067931.16 and AC107375.5. On May 31, 2019 this sequence version replaced NM_001164623.2. Summary: This gene encodes a member of the Argonaute family of proteins which play a role in RNA interference. The encoded protein is highly basic, and contains a PAZ domain and a PIWI domain. It may interact with dicer1 and play a role in short-interfering-RNA-mediated gene silencing. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]....","source":"Homo sapiens (human)","symbol":"AGO2","synonym":"CASC7; EIF2C2; LESKRES; LINC00980; PPD; Q10","version":"NM_001164623.3"},{"aa_position":[],"accession":"NM_012199","definition":"Homo sapiens argonaute RISC component 1 (AGO1), transcript variant 1, mRNA.","division":"RefSeq","geneid":"26523","gi":"","length":"13712","nt_position":[],"snippet":"was derived from HY052874.1, BC063275.1, AK314148.1, AF093097.1, CR936823.1 and AL139286.13. On Nov 23, 2018 this sequence version replaced NM_012199.4. Summary: This gene encodes a member of the argonaute family of proteins, which associate with small RNAs and have important roles in RNA interference (RNAi) and RNA silencing. This protein binds to microRNAs (miRNAs) or small interfering RNAs (siRNAs) and represses translation of mRNAs that are complementary to them. It is also involved in transcriptional gene silencing (TGS) of promoter regions that are complementary to bound short antigene...","source":"Homo sapiens (human)","symbol":"AGO1","synonym":"EIF2C; EIF2C1; GERP95; hAgo1; NEDLBAS; Q99","version":"NM_012199.5"},{"aa_position":[],"accession":"NM_001394785","definition":"Homo sapiens nuclear factor of activated T cells 2 interacting protein (NFATC2IP), transcript variant 3, mRNA.","division":"RefSeq","geneid":"84901","gi":"","length":"4309","nt_position":[],"snippet":"differentiation, and lineage-specific transcription factors including ZBTB25 as a novel NF-AT repressor JOURNAL Blood 115 (26), 5376-5384 (2010) PUBMED 20410506 REMARK GeneRIF: ZBTB25 functions as a negative regulator of nuclear factor of activated T cells (NF-AT) activation, such that RNA interference mediated knockdown resulted in enhanced activation of target genes. REFERENCE 8 (bases 1 to 4309) AUTHORS Beausoleil,S.A., Villen,J., Gerber,S.A., Rush,J. and Gygi,S.P. TITLE A probability-based approach for high-throughput protein phosphorylation analysis and site localization JOURNAL Nat...","source":"Homo sapiens (human)","symbol":"NFATC2IP","synonym":"ESC2; NIP45; RAD60","version":"NM_001394785.1"},{"aa_position":[],"accession":"NM_001395696","definition":"Homo sapiens dicer 1, ribonuclease III (DICER1), transcript variant 25, mRNA.","division":"RefSeq","geneid":"23405","gi":"","length":"5788","nt_position":[],"snippet":"reference sequence was derived from AL356017.3 and AL390254.6. Summary: This gene encodes a protein possessing an RNA helicase motif containing a DEXH box in its amino terminus and an RNA motif in the carboxy terminus. The encoded protein functions as a ribonuclease and is required by the RNA interference and small temporal RNA (stRNA) pathways to produce the active small RNA component that represses gene expression. This protein also acts as a strong antiviral agent with activity against RNA viruses, including the Zika and SARS-CoV-2 viruses. Alternative splicing results in multiple...","source":"Homo sapiens (human)","symbol":"DICER1","synonym":"aviD; DCR1; Dicer; Dicer1e; GLOW; HERNA; K12H4.8-LIKE; MNG1; RMSE2","version":"NM_001395696.1"},{"aa_position":[],"accession":"NM_001395233","definition":"Homo sapiens coiled-coil domain containing 7 (CCDC7), transcript variant 7, mRNA.","division":"RefSeq","geneid":"79741","gi":"","length":"3902","nt_position":[],"snippet":"regular exercise JOURNAL Physiol Genomics 36 (2), 79-88 (2009) PUBMED 18984674 REMARK GeneRIF: Observational study of gene-disease association. (HuGE Navigator) REFERENCE 6 (bases 1 to 3902) AUTHORS Wang,C.T., Zhang,P., Wang,Y.S., Ruan,X.Z., Li,Z.Y., Peng,F., Yang,H.S. and Wei,Y.Q. TITLE RNA interference against Biot2, a novel mouse testis-specific gene, inhibits the growth of tumor cells JOURNAL Cell Mol Biol Lett 14 (3), 363-376 (2009) PUBMED 19277478 REFERENCE 7 (bases 1 to 3902) AUTHORS Grupe,A., Li,Y., Rowland,C., Nowotny,P., Hinrichs,A.L., Smemo,S., Kauwe,J.S., Maxwell,T.J., Cherny,S.,...","source":"Homo sapiens (human)","symbol":"CCDC7","synonym":"BIOT2; BioT2-A; BioT2-B; BioT2-C; C10orf68","version":"NM_001395233.1"},{"aa_position":[],"accession":"NR_130710","definition":"Homo sapiens ADAM metallopeptidase domain 28 (ADAM28), transcript variant 6, non-coding RNA.","division":"RefSeq","geneid":"10863","gi":"","length":"7085","nt_position":[],"snippet":"D. TITLE ADAM28: Another ambivalent protease in cancer JOURNAL Cancer Lett 494, 18-26 (2020) PUBMED 32861707 REMARK GeneRIF: ADAM28: Another ambivalent protease in cancer. Review article REFERENCE 4 (bases 1 to 7085) AUTHORS Zhao Z, Qiu HY, Fu L and Li J. TITLE [Construction of ADAM28 shRNA interference vector and its inhibitory effect on human periodontal ligament stem cells] JOURNAL Shanghai Kou Qiang Yi Xue 29 (5), 476-481 (2020) PUBMED 33543212 REMARK GeneRIF: [Construction of ADAM28 shRNA interference vector and its inhibitory effect on human periodontal ligament stem cells]. REFERENCE...","source":"Homo sapiens (human)","symbol":"ADAM28","synonym":"ADAM 28; eMDC II; eMDCII; MDC-L; MDCL","version":"NR_130710.2"},{"aa_position":[],"accession":"NM_001394784","definition":"Homo sapiens nuclear factor of activated T cells 2 interacting protein (NFATC2IP), transcript variant 2, mRNA.","division":"RefSeq","geneid":"84901","gi":"","length":"4483","nt_position":[],"snippet":"differentiation, and lineage-specific transcription factors including ZBTB25 as a novel NF-AT repressor JOURNAL Blood 115 (26), 5376-5384 (2010) PUBMED 20410506 REMARK GeneRIF: ZBTB25 functions as a negative regulator of nuclear factor of activated T cells (NF-AT) activation, such that RNA interference mediated knockdown resulted in enhanced activation of target genes. REFERENCE 8 (bases 1 to 4483) AUTHORS Beausoleil,S.A., Villen,J., Gerber,S.A., Rush,J. and Gygi,S.P. TITLE A probability-based approach for high-throughput protein phosphorylation analysis and site localization JOURNAL Nat...","source":"Homo sapiens (human)","symbol":"NFATC2IP","synonym":"ESC2; NIP45; RAD60","version":"NM_001394784.1"},{"aa_position":[],"accession":"NM_001395694","definition":"Homo sapiens dicer 1, ribonuclease III (DICER1), transcript variant 23, mRNA.","division":"RefSeq","geneid":"23405","gi":"","length":"5925","nt_position":[],"snippet":"reference sequence was derived from AL356017.3 and AL390254.6. Summary: This gene encodes a protein possessing an RNA helicase motif containing a DEXH box in its amino terminus and an RNA motif in the carboxy terminus. The encoded protein functions as a ribonuclease and is required by the RNA interference and small temporal RNA (stRNA) pathways to produce the active small RNA component that represses gene expression. This protein also acts as a strong antiviral agent with activity against RNA viruses, including the Zika and SARS-CoV-2 viruses. Alternative splicing results in multiple...","source":"Homo sapiens (human)","symbol":"DICER1","synonym":"aviD; DCR1; Dicer; Dicer1e; GLOW; HERNA; K12H4.8-LIKE; MNG1; RMSE2","version":"NM_001395694.1"},{"aa_position":[],"accession":"NM_001395693","definition":"Homo sapiens dicer 1, ribonuclease III (DICER1), transcript variant 22, mRNA.","division":"RefSeq","geneid":"23405","gi":"","length":"5919","nt_position":[],"snippet":"reference sequence was derived from AL356017.3 and AL390254.6. Summary: This gene encodes a protein possessing an RNA helicase motif containing a DEXH box in its amino terminus and an RNA motif in the carboxy terminus. The encoded protein functions as a ribonuclease and is required by the RNA interference and small temporal RNA (stRNA) pathways to produce the active small RNA component that represses gene expression. This protein also acts as a strong antiviral agent with activity against RNA viruses, including the Zika and SARS-CoV-2 viruses. Alternative splicing results in multiple...","source":"Homo sapiens (human)","symbol":"DICER1","synonym":"aviD; DCR1; Dicer; Dicer1e; GLOW; HERNA; K12H4.8-LIKE; MNG1; RMSE2","version":"NM_001395693.1"},{"aa_position":[],"accession":"NM_001395695","definition":"Homo sapiens dicer 1, ribonuclease III (DICER1), transcript variant 24, mRNA.","division":"RefSeq","geneid":"23405","gi":"","length":"6020","nt_position":[],"snippet":"reference sequence was derived from AL356017.3 and AL390254.6. Summary: This gene encodes a protein possessing an RNA helicase motif containing a DEXH box in its amino terminus and an RNA motif in the carboxy terminus. The encoded protein functions as a ribonuclease and is required by the RNA interference and small temporal RNA (stRNA) pathways to produce the active small RNA component that represses gene expression. This protein also acts as a strong antiviral agent with activity against RNA viruses, including the Zika and SARS-CoV-2 viruses. Alternative splicing results in multiple...","source":"Homo sapiens (human)","symbol":"DICER1","synonym":"aviD; DCR1; Dicer; Dicer1e; GLOW; HERNA; K12H4.8-LIKE; MNG1; RMSE2","version":"NM_001395695.1"},{"aa_position":[],"accession":"NM_001395692","definition":"Homo sapiens dicer 1, ribonuclease III (DICER1), transcript variant 21, mRNA.","division":"RefSeq","geneid":"23405","gi":"","length":"6086","nt_position":[],"snippet":"reference sequence was derived from AL356017.3 and AL390254.6. Summary: This gene encodes a protein possessing an RNA helicase motif containing a DEXH box in its amino terminus and an RNA motif in the carboxy terminus. The encoded protein functions as a ribonuclease and is required by the RNA interference and small temporal RNA (stRNA) pathways to produce the active small RNA component that represses gene expression. This protein also acts as a strong antiviral agent with activity against RNA viruses, including the Zika and SARS-CoV-2 viruses. Alternative splicing results in multiple...","source":"Homo sapiens (human)","symbol":"DICER1","synonym":"aviD; DCR1; Dicer; Dicer1e; GLOW; HERNA; K12H4.8-LIKE; MNG1; RMSE2","version":"NM_001395692.1"},{"aa_position":[],"accession":"NM_032815","definition":"Homo sapiens nuclear factor of activated T cells 2 interacting protein (NFATC2IP), transcript variant 1, mRNA.","division":"RefSeq","geneid":"84901","gi":"","length":"4564","nt_position":[],"snippet":"differentiation, and lineage-specific transcription factors including ZBTB25 as a novel NF-AT repressor JOURNAL Blood 115 (26), 5376-5384 (2010) PUBMED 20410506 REMARK GeneRIF: ZBTB25 functions as a negative regulator of nuclear factor of activated T cells (NF-AT) activation, such that RNA interference mediated knockdown resulted in enhanced activation of target genes. REFERENCE 8 (bases 1 to 4564) AUTHORS Beausoleil,S.A., Villen,J., Gerber,S.A., Rush,J. and Gygi,S.P. TITLE A probability-based approach for high-throughput protein phosphorylation analysis and site localization JOURNAL Nat...","source":"Homo sapiens (human)","symbol":"NFATC2IP","synonym":"ESC2; NIP45; RAD60","version":"NM_032815.4"},{"aa_position":[],"accession":"NM_001310327","definition":"Homo sapiens iron-sulfur cluster assembly factor IBA57 (IBA57), transcript variant 2, mRNA; nuclear gene for mitochondrial product.","division":"RefSeq","geneid":"200205","gi":"","length":"7515","nt_position":[],"snippet":"O., Niggemeyer,B., Elsasser,H.P., Muhlenhoff,U. and Lill,R. TITLE The human mitochondrial ISCA1, ISCA2, and IBA57 proteins are required for [4Fe-4S] protein maturation JOURNAL Mol Biol Cell 23 (7), 1157-1166 (2012) PUBMED 22323289 REMARK GeneRIF: ISCA1, ISCA2, and IBA57 were depleted by RNA interference. Depleted cells contained massively swollen and enlarged mitochondria that were virtually devoid of cristae membranes, demonstrating the importance of these proteins for mitochondrial biogenesis. REFERENCE 8 (bases 1 to 7515) AUTHORS Hendrickson,S.L., Lautenberger,J.A., Chinn,L.W., Malasky,M.,...","source":"Homo sapiens (human)","symbol":"IBA57","synonym":"C1orf69; MMDS3; SPG74","version":"NM_001310327.2"},{"aa_position":[],"accession":"NM_001320547","definition":"Homo sapiens WD repeat domain 6 (WDR6), transcript variant 3, mRNA.","division":"RefSeq","geneid":"11180","gi":"","length":"3984","nt_position":[],"snippet":"M.A. TITLE A reference map of the human binary protein interactome JOURNAL Nature 580 (7803), 402-408 (2020) PUBMED 32296183 REFERENCE 3 (bases 1 to 3984) AUTHORS Sivan,G., Ormanoglu,P., Buehler,E.C., Martin,S.E. and Moss,B. TITLE Identification of Restriction Factors by Human Genome-Wide RNA Interference Screening of Viral Host Range Mutants Exemplified by Discovery of SAMD9 and WDR6 as Inhibitors of the Vaccinia Virus K1L-C7L- Mutant JOURNAL mBio 6 (4), e01122 (2015) PUBMED 26242627 REMARK GeneRIF: Replication of the K1L(-)C7L(-) mutant vaccinia virus virus was enabled by multiple siRNAs to...","source":"Homo sapiens (human)","symbol":"WDR6","synonym":"Trm734","version":"NM_001320547.2"},{"aa_position":[],"accession":"NM_018031","definition":"Homo sapiens WD repeat domain 6 (WDR6), transcript variant 1, mRNA.","division":"RefSeq","geneid":"11180","gi":"","length":"4070","nt_position":[],"snippet":"M.A. TITLE A reference map of the human binary protein interactome JOURNAL Nature 580 (7803), 402-408 (2020) PUBMED 32296183 REFERENCE 3 (bases 1 to 4070) AUTHORS Sivan,G., Ormanoglu,P., Buehler,E.C., Martin,S.E. and Moss,B. TITLE Identification of Restriction Factors by Human Genome-Wide RNA Interference Screening of Viral Host Range Mutants Exemplified by Discovery of SAMD9 and WDR6 as Inhibitors of the Vaccinia Virus K1L-C7L- Mutant JOURNAL mBio 6 (4), e01122 (2015) PUBMED 26242627 REMARK GeneRIF: Replication of the K1L(-)C7L(-) mutant vaccinia virus virus was enabled by multiple siRNAs to...","source":"Homo sapiens (human)","symbol":"WDR6","synonym":"Trm734","version":"NM_018031.6"},{"aa_position":[],"accession":"NM_005407","definition":"Homo sapiens spalt like transcription factor 2 (SALL2), transcript variant 1, mRNA.","division":"RefSeq","geneid":"6297","gi":"","length":"4848","nt_position":[],"snippet":"function. REFERENCE 3 (bases 1 to 4848) AUTHORS Miao,F., Zhang,X., Cao,Y., Wang,Y. and Zhang,X. TITLE Effect of siRNA-silencing of SALL2 gene on growth, migration and invasion of human ovarian carcinoma A2780 cells JOURNAL BMC Cancer 17 (1), 838 (2017) PUBMED 29228922 REMARK GeneRIF: Using RNA interference, the role of Spalt-like gene-2 (SALL2) was investigated in human ovarian carcinoma (OC) A2780 cells. Found downregulation of SALL2 promoted growth of the OC cell line. Publication Status: Online-Only REFERENCE 4 (bases 1 to 4848) AUTHORS Hermosilla,V.E., Hepp,M.I., Escobar,D., Farkas,C.,...","source":"Homo sapiens (human)","symbol":"SALL2","synonym":"COLB; HSAL2; p150(Sal2); Sal-2; ZNF795","version":"NM_005407.3"},{"aa_position":[],"accession":"NR_172207","definition":"Homo sapiens nuclear factor of activated T cells 2 interacting protein (NFATC2IP), transcript variant 5, non-coding RNA.","division":"RefSeq","geneid":"84901","gi":"","length":"4296","nt_position":[],"snippet":"differentiation, and lineage-specific transcription factors including ZBTB25 as a novel NF-AT repressor JOURNAL Blood 115 (26), 5376-5384 (2010) PUBMED 20410506 REMARK GeneRIF: ZBTB25 functions as a negative regulator of nuclear factor of activated T cells (NF-AT) activation, such that RNA interference mediated knockdown resulted in enhanced activation of target genes. REFERENCE 8 (bases 1 to 4296) AUTHORS Beausoleil,S.A., Villen,J., Gerber,S.A., Rush,J. and Gygi,S.P. TITLE A probability-based approach for high-throughput protein phosphorylation analysis and site localization JOURNAL Nat...","source":"Homo sapiens (human)","symbol":"NFATC2IP","synonym":"ESC2; NIP45; RAD60","version":"NR_172207.1"},{"aa_position":[],"accession":"NM_001364564","definition":"Homo sapiens spalt like transcription factor 2 (SALL2), transcript variant 6, mRNA.","division":"RefSeq","geneid":"6297","gi":"","length":"4861","nt_position":[],"snippet":"function. REFERENCE 3 (bases 1 to 4861) AUTHORS Miao,F., Zhang,X., Cao,Y., Wang,Y. and Zhang,X. TITLE Effect of siRNA-silencing of SALL2 gene on growth, migration and invasion of human ovarian carcinoma A2780 cells JOURNAL BMC Cancer 17 (1), 838 (2017) PUBMED 29228922 REMARK GeneRIF: Using RNA interference, the role of Spalt-like gene-2 (SALL2) was investigated in human ovarian carcinoma (OC) A2780 cells. Found downregulation of SALL2 promoted growth of the OC cell line. Publication Status: Online-Only REFERENCE 4 (bases 1 to 4861) AUTHORS Hermosilla,V.E., Hepp,M.I., Escobar,D., Farkas,C.,...","source":"Homo sapiens (human)","symbol":"SALL2","synonym":"COLB; HSAL2; p150(Sal2); Sal-2; ZNF795","version":"NM_001364564.1"},{"aa_position":[],"accession":"NM_001395698","definition":"Homo sapiens dicer 1, ribonuclease III (DICER1), transcript variant 28, mRNA.","division":"RefSeq","geneid":"23405","gi":"","length":"3925","nt_position":[],"snippet":"NCBI staff. The reference sequence was derived from AL356017.3. Summary: This gene encodes a protein possessing an RNA helicase motif containing a DEXH box in its amino terminus and an RNA motif in the carboxy terminus. The encoded protein functions as a ribonuclease and is required by the RNA interference and small temporal RNA (stRNA) pathways to produce the active small RNA component that represses gene expression. This protein also acts as a strong antiviral agent with activity against RNA viruses, including the Zika and SARS-CoV-2 viruses. Alternative splicing results in multiple...","source":"Homo sapiens (human)","symbol":"DICER1","synonym":"aviD; DCR1; Dicer; Dicer1e; GLOW; HERNA; K12H4.8-LIKE; MNG1; RMSE2","version":"NM_001395698.1"},{"aa_position":[],"accession":"NR_109827","definition":"Homo sapiens coiled-coil domain containing 7 (CCDC7), transcript variant 4, non-coding RNA.","division":"RefSeq","geneid":"79741","gi":"","length":"4251","nt_position":[],"snippet":"regular exercise JOURNAL Physiol Genomics 36 (2), 79-88 (2009) PUBMED 18984674 REMARK GeneRIF: Observational study of gene-disease association. (HuGE Navigator) REFERENCE 6 (bases 1 to 4251) AUTHORS Wang,C.T., Zhang,P., Wang,Y.S., Ruan,X.Z., Li,Z.Y., Peng,F., Yang,H.S. and Wei,Y.Q. TITLE RNA interference against Biot2, a novel mouse testis-specific gene, inhibits the growth of tumor cells JOURNAL Cell Mol Biol Lett 14 (3), 363-376 (2009) PUBMED 19277478 REFERENCE 7 (bases 1 to 4251) AUTHORS Grupe,A., Li,Y., Rowland,C., Nowotny,P., Hinrichs,A.L., Smemo,S., Kauwe,J.S., Maxwell,T.J., Cherny,S.,...","source":"Homo sapiens (human)","symbol":"CCDC7","synonym":"BIOT2; BioT2-A; BioT2-B; BioT2-C; C10orf68","version":"NR_109827.2"},{"aa_position":[],"accession":"NM_001320546","definition":"Homo sapiens WD repeat domain 6 (WDR6), transcript variant 2, mRNA.","division":"RefSeq","geneid":"11180","gi":"","length":"4284","nt_position":[],"snippet":"M.A. TITLE A reference map of the human binary protein interactome JOURNAL Nature 580 (7803), 402-408 (2020) PUBMED 32296183 REFERENCE 3 (bases 1 to 4284) AUTHORS Sivan,G., Ormanoglu,P., Buehler,E.C., Martin,S.E. and Moss,B. TITLE Identification of Restriction Factors by Human Genome-Wide RNA Interference Screening of Viral Host Range Mutants Exemplified by Discovery of SAMD9 and WDR6 as Inhibitors of the Vaccinia Virus K1L-C7L- Mutant JOURNAL mBio 6 (4), e01122 (2015) PUBMED 26242627 REMARK GeneRIF: Replication of the K1L(-)C7L(-) mutant vaccinia virus virus was enabled by multiple siRNAs to...","source":"Homo sapiens (human)","symbol":"WDR6","synonym":"Trm734","version":"NM_001320546.3"},{"aa_position":[],"accession":"NM_001010867","definition":"Homo sapiens iron-sulfur cluster assembly factor IBA57 (IBA57), transcript variant 1, mRNA; nuclear gene for mitochondrial product.","division":"RefSeq","geneid":"200205","gi":"","length":"7828","nt_position":[],"snippet":"O., Niggemeyer,B., Elsasser,H.P., Muhlenhoff,U. and Lill,R. TITLE The human mitochondrial ISCA1, ISCA2, and IBA57 proteins are required for [4Fe-4S] protein maturation JOURNAL Mol Biol Cell 23 (7), 1157-1166 (2012) PUBMED 22323289 REMARK GeneRIF: ISCA1, ISCA2, and IBA57 were depleted by RNA interference. Depleted cells contained massively swollen and enlarged mitochondria that were virtually devoid of cristae membranes, demonstrating the importance of these proteins for mitochondrial biogenesis. REFERENCE 8 (bases 1 to 7828) AUTHORS Hendrickson,S.L., Lautenberger,J.A., Chinn,L.W., Malasky,M.,...","source":"Homo sapiens (human)","symbol":"IBA57","synonym":"C1orf69; MMDS3; SPG74","version":"NM_001010867.4"},{"aa_position":[],"accession":"NM_001300906","definition":"Homo sapiens inhibitor of Bruton tyrosine kinase (IBTK), transcript variant 2, mRNA.","division":"RefSeq","geneid":"25998","gi":"","length":"5995","nt_position":[],"snippet":"M., Scala,G. and Quinto,I. TITLE The expression of inhibitor of bruton's tyrosine kinase gene is progressively up regulated in the clinical course of chronic lymphocytic leukaemia conferring resistance to apoptosis JOURNAL Cell Death Dis 9 (1), 13 (2018) PUBMED 29317636 REMARK GeneRIF: RNA interference of Inhibitor of brutons tyrosine kinase-isoform alpha up regulated the expression of pro-apoptotic genes, including TNF, CRADD, CASP7, BNIP3 and BIRC3 and is a novel marker of CLL progression promoting cell growth and resistance to apoptosis. Publication Status: Online-Only REFERENCE 3...","source":"Homo sapiens (human)","symbol":"IBTK","synonym":"BTBD26; BTKI","version":"NM_001300906.2"},{"aa_position":[],"accession":"NM_199053","definition":"Homo sapiens trafficking protein particle complex subunit 11 (TRAPPC11), transcript variant 2, mRNA.","division":"RefSeq","geneid":"60684","gi":"","length":"4404","nt_position":[],"snippet":"an early stage in ER-to-Golgi trafficking JOURNAL Mol Biol Cell 22 (12), 2083-2093 (2011) PUBMED 21525244 REFERENCE 10 (bases 1 to 4404) AUTHORS Wendler,F., Gillingham,A.K., Sinka,R., Rosa-Ferreira,C., Gordon,D.E., Franch-Marro,X., Peden,A.A., Vincent,J.P. and Munro,S. TITLE A genome-wide RNA interference screen identifies two novel components of the metazoan secretory pathway JOURNAL EMBO J 29 (2), 304-314 (2010) PUBMED 19942856...","source":"Homo sapiens (human)","symbol":"TRAPPC11","synonym":"C4orf41; FOIGR; GRY; LGMD2S; LGMDR18","version":"NM_199053.3"},{"aa_position":[],"accession":"NM_015525","definition":"Homo sapiens inhibitor of Bruton tyrosine kinase (IBTK), transcript variant 1, mRNA.","division":"RefSeq","geneid":"25998","gi":"","length":"6040","nt_position":[],"snippet":"M., Scala,G. and Quinto,I. TITLE The expression of inhibitor of bruton's tyrosine kinase gene is progressively up regulated in the clinical course of chronic lymphocytic leukaemia conferring resistance to apoptosis JOURNAL Cell Death Dis 9 (1), 13 (2018) PUBMED 29317636 REMARK GeneRIF: RNA interference of Inhibitor of brutons tyrosine kinase-isoform alpha up regulated the expression of pro-apoptotic genes, including TNF, CRADD, CASP7, BNIP3 and BIRC3 and is a novel marker of CLL progression promoting cell growth and resistance to apoptosis. Publication Status: Online-Only REFERENCE 3...","source":"Homo sapiens (human)","symbol":"IBTK","synonym":"BTBD26; BTKI","version":"NM_015525.4"},{"aa_position":[],"accession":"NM_021942","definition":"Homo sapiens trafficking protein particle complex subunit 11 (TRAPPC11), transcript variant 1, mRNA.","division":"RefSeq","geneid":"60684","gi":"","length":"4523","nt_position":[],"snippet":"an early stage in ER-to-Golgi trafficking JOURNAL Mol Biol Cell 22 (12), 2083-2093 (2011) PUBMED 21525244 REFERENCE 10 (bases 1 to 4523) AUTHORS Wendler,F., Gillingham,A.K., Sinka,R., Rosa-Ferreira,C., Gordon,D.E., Franch-Marro,X., Peden,A.A., Vincent,J.P. and Munro,S. TITLE A genome-wide RNA interference screen identifies two novel components of the metazoan secretory pathway JOURNAL EMBO J 29 (2), 304-314 (2010) PUBMED 19942856...","source":"Homo sapiens (human)","symbol":"TRAPPC11","synonym":"C4orf41; FOIGR; GRY; LGMD2S; LGMDR18","version":"NM_021942.6"},{"aa_position":[],"accession":"NM_007174","definition":"Homo sapiens citron rho-interacting serine/threonine kinase (CIT), transcript variant 2, mRNA.","division":"RefSeq","geneid":"11113","gi":"","length":"8610","nt_position":[],"snippet":"JOURNAL Nat Commun 13 (1), 5472 (2022) PUBMED 36115835 REMARK Erratum:[Nat Commun. 2022 Dec 7;13(1):7555. doi: 10.1038/s41467-022-35177-6. PMID: 36477203] Publication Status: Online-Only REFERENCE 4 (bases 1 to 8610) AUTHORS Fu,Y., Huang,J., Wang,K.S., Zhang,X. and Han,Z.G. TITLE RNA interference targeting CITRON can significantly inhibit the proliferation of hepatocellular carcinoma cells JOURNAL Mol Biol Rep 38 (2), 693-702 (2011) PUBMED 20369383 REMARK GeneRIF: CITRON has a role in proliferation of hepatocellular carcinoma cells REFERENCE 5 (bases 1 to 8610) AUTHORS Nicodemus,K.K.,...","source":"Homo sapiens (human)","symbol":"CIT","synonym":"CITK; CRIK; MCPH17; STK21","version":"NM_007174.3"},{"aa_position":[],"accession":"NM_001206999","definition":"Homo sapiens citron rho-interacting serine/threonine kinase (CIT), transcript variant 1, mRNA.","division":"RefSeq","geneid":"11113","gi":"","length":"8736","nt_position":[],"snippet":"JOURNAL Nat Commun 13 (1), 5472 (2022) PUBMED 36115835 REMARK Erratum:[Nat Commun. 2022 Dec 7;13(1):7555. doi: 10.1038/s41467-022-35177-6. PMID: 36477203] Publication Status: Online-Only REFERENCE 4 (bases 1 to 8736) AUTHORS Fu,Y., Huang,J., Wang,K.S., Zhang,X. and Han,Z.G. TITLE RNA interference targeting CITRON can significantly inhibit the proliferation of hepatocellular carcinoma cells JOURNAL Mol Biol Rep 38 (2), 693-702 (2011) PUBMED 20369383 REMARK GeneRIF: CITRON has a role in proliferation of hepatocellular carcinoma cells REFERENCE 5 (bases 1 to 8736) AUTHORS Nicodemus,K.K.,...","source":"Homo sapiens (human)","symbol":"CIT","synonym":"CITK; CRIK; MCPH17; STK21","version":"NM_001206999.2"},{"aa_position":[],"accession":"NM_001195573","definition":"Homo sapiens dicer 1, ribonuclease III (DICER1), transcript variant 3, mRNA.","division":"RefSeq","geneid":"23405","gi":"","length":"9921","nt_position":[],"snippet":"was derived from AL356017.3, HM595745.1 and AL390254.6. Summary: This gene encodes a protein possessing an RNA helicase motif containing a DEXH box in its amino terminus and an RNA motif in the carboxy terminus. The encoded protein functions as a ribonuclease and is required by the RNA interference and small temporal RNA (stRNA) pathways to produce the active small RNA component that represses gene expression. This protein also acts as a strong antiviral agent with activity against RNA viruses, including the Zika and SARS-CoV-2 viruses. Alternative splicing results in multiple transcript...","source":"Homo sapiens (human)","symbol":"DICER1","synonym":"aviD; DCR1; Dicer; Dicer1e; GLOW; HERNA; K12H4.8-LIKE; MNG1; RMSE2","version":"NM_001195573.1"},{"aa_position":[],"accession":"NM_001318139","definition":"Homo sapiens myocardin related transcription factor A (MRTFA), transcript variant 5, mRNA.","division":"RefSeq","geneid":"57591","gi":"","length":"4194","nt_position":[],"snippet":"for serum response factor (SRF), is required for serum induction of SRF target genes JOURNAL Mol Cell Biol 23 (18), 6597-6608 (2003) PUBMED 12944485 REMARK GeneRIF: Role of MKL1 in serum induction of c-fos and other SRE-regulated genes with a dominant negative MKL1 mutant (DN-MKL1) and RNA interference (RNAi) was assessed. DN-MKL1 and RNAi specifically blocked SRE-dependent reporter gene activation by serum and RhoA REFERENCE 8 (bases 1 to 4194) AUTHORS Ma,Z., Morris,S.W., Valentine,V., Li,M., Herbrick,J.A., Cui,X., Bouman,D., Li,Y., Mehta,P.K., Nizetic,D., Kaneko,Y., Chan,G.C., Chan,L.C.,...","source":"Homo sapiens (human)","symbol":"MRTFA","synonym":"BSAC; MAL; MKL; MKL1; MRTF-A","version":"NM_001318139.2"},{"aa_position":[],"accession":"NM_001282660","definition":"Homo sapiens myocardin related transcription factor A (MRTFA), transcript variant 2, mRNA.","division":"RefSeq","geneid":"57591","gi":"","length":"4110","nt_position":[],"snippet":"for serum response factor (SRF), is required for serum induction of SRF target genes JOURNAL Mol Cell Biol 23 (18), 6597-6608 (2003) PUBMED 12944485 REMARK GeneRIF: Role of MKL1 in serum induction of c-fos and other SRE-regulated genes with a dominant negative MKL1 mutant (DN-MKL1) and RNA interference (RNAi) was assessed. DN-MKL1 and RNAi specifically blocked SRE-dependent reporter gene activation by serum and RhoA REFERENCE 8 (bases 1 to 4110) AUTHORS Ma,Z., Morris,S.W., Valentine,V., Li,M., Herbrick,J.A., Cui,X., Bouman,D., Li,Y., Mehta,P.K., Nizetic,D., Kaneko,Y., Chan,G.C., Chan,L.C.,...","source":"Homo sapiens (human)","symbol":"MRTFA","synonym":"BSAC; MAL; MKL; MKL1; MRTF-A","version":"NM_001282660.2"},{"aa_position":[],"accession":"NM_001395687","definition":"Homo sapiens dicer 1, ribonuclease III (DICER1), transcript variant 16, mRNA.","division":"RefSeq","geneid":"23405","gi":"","length":"10064","nt_position":[],"snippet":"reference sequence was derived from AL356017.3 and AL390254.6. Summary: This gene encodes a protein possessing an RNA helicase motif containing a DEXH box in its amino terminus and an RNA motif in the carboxy terminus. The encoded protein functions as a ribonuclease and is required by the RNA interference and small temporal RNA (stRNA) pathways to produce the active small RNA component that represses gene expression. This protein also acts as a strong antiviral agent with activity against RNA viruses, including the Zika and SARS-CoV-2 viruses. Alternative splicing results in multiple...","source":"Homo sapiens (human)","symbol":"DICER1","synonym":"aviD; DCR1; Dicer; Dicer1e; GLOW; HERNA; K12H4.8-LIKE; MNG1; RMSE2","version":"NM_001395687.1"},{"aa_position":[],"accession":"NM_001282661","definition":"Homo sapiens myocardin related transcription factor A (MRTFA), transcript variant 3, mRNA.","division":"RefSeq","geneid":"57591","gi":"","length":"4372","nt_position":[],"snippet":"for serum response factor (SRF), is required for serum induction of SRF target genes JOURNAL Mol Cell Biol 23 (18), 6597-6608 (2003) PUBMED 12944485 REMARK GeneRIF: Role of MKL1 in serum induction of c-fos and other SRE-regulated genes with a dominant negative MKL1 mutant (DN-MKL1) and RNA interference (RNAi) was assessed. DN-MKL1 and RNAi specifically blocked SRE-dependent reporter gene activation by serum and RhoA REFERENCE 8 (bases 1 to 4372) AUTHORS Ma,Z., Morris,S.W., Valentine,V., Li,M., Herbrick,J.A., Cui,X., Bouman,D., Li,Y., Mehta,P.K., Nizetic,D., Kaneko,Y., Chan,G.C., Chan,L.C.,...","source":"Homo sapiens (human)","symbol":"MRTFA","synonym":"BSAC; MAL; MKL; MKL1; MRTF-A","version":"NM_001282661.3"},{"aa_position":[],"accession":"NM_001395700","definition":"Homo sapiens dicer 1, ribonuclease III (DICER1), transcript variant 30, mRNA.","division":"RefSeq","geneid":"23405","gi":"","length":"6930","nt_position":[],"snippet":"NCBI staff. The reference sequence was derived from AL356017.3. Summary: This gene encodes a protein possessing an RNA helicase motif containing a DEXH box in its amino terminus and an RNA motif in the carboxy terminus. The encoded protein functions as a ribonuclease and is required by the RNA interference and small temporal RNA (stRNA) pathways to produce the active small RNA component that represses gene expression. This protein also acts as a strong antiviral agent with activity against RNA viruses, including the Zika and SARS-CoV-2 viruses. Alternative splicing results in multiple...","source":"Homo sapiens (human)","symbol":"DICER1","synonym":"aviD; DCR1; Dicer; Dicer1e; GLOW; HERNA; K12H4.8-LIKE; MNG1; RMSE2","version":"NM_001395700.1"},{"aa_position":[],"accession":"NM_001395690","definition":"Homo sapiens dicer 1, ribonuclease III (DICER1), transcript variant 19, mRNA.","division":"RefSeq","geneid":"23405","gi":"","length":"10259","nt_position":[],"snippet":"reference sequence was derived from AL356017.3 and AL390254.6. Summary: This gene encodes a protein possessing an RNA helicase motif containing a DEXH box in its amino terminus and an RNA motif in the carboxy terminus. The encoded protein functions as a ribonuclease and is required by the RNA interference and small temporal RNA (stRNA) pathways to produce the active small RNA component that represses gene expression. This protein also acts as a strong antiviral agent with activity against RNA viruses, including the Zika and SARS-CoV-2 viruses. Alternative splicing results in multiple...","source":"Homo sapiens (human)","symbol":"DICER1","synonym":"aviD; DCR1; Dicer; Dicer1e; GLOW; HERNA; K12H4.8-LIKE; MNG1; RMSE2","version":"NM_001395690.1"},{"aa_position":[],"accession":"NM_001291628","definition":"Homo sapiens dicer 1, ribonuclease III (DICER1), transcript variant 5, mRNA.","division":"RefSeq","geneid":"23405","gi":"","length":"10160","nt_position":[],"snippet":"On Aug 13, 2020 this sequence version replaced NM_001291628.1. Summary: This gene encodes a protein possessing an RNA helicase motif containing a DEXH box in its amino terminus and an RNA motif in the carboxy terminus. The encoded protein functions as a ribonuclease and is required by the RNA interference and small temporal RNA (stRNA) pathways to produce the active small RNA component that represses gene expression. This protein also acts as a strong antiviral agent with activity against RNA viruses, including the Zika and SARS-CoV-2 viruses. Alternative splicing results in multiple...","source":"Homo sapiens (human)","symbol":"DICER1","synonym":"aviD; DCR1; Dicer; Dicer1e; GLOW; HERNA; K12H4.8-LIKE; MNG1; RMSE2","version":"NM_001291628.2"},{"aa_position":[],"accession":"NM_001271282","definition":"Homo sapiens dicer 1, ribonuclease III (DICER1), transcript variant 4, mRNA.","division":"RefSeq","geneid":"23405","gi":"","length":"10263","nt_position":[],"snippet":"On Jun 2, 2019 this sequence version replaced NM_001271282.2. Summary: This gene encodes a protein possessing an RNA helicase motif containing a DEXH box in its amino terminus and an RNA motif in the carboxy terminus. The encoded protein functions as a ribonuclease and is required by the RNA interference and small temporal RNA (stRNA) pathways to produce the active small RNA component that represses gene expression. This protein also acts as a strong antiviral agent with activity against RNA viruses, including the Zika and SARS-CoV-2 viruses. Alternative splicing results in multiple transcript...","source":"Homo sapiens (human)","symbol":"DICER1","synonym":"aviD; DCR1; Dicer; Dicer1e; GLOW; HERNA; K12H4.8-LIKE; MNG1; RMSE2","version":"NM_001271282.3"},{"aa_position":[],"accession":"NM_001354635","definition":"Homo sapiens exoribonuclease 1 (ERI1), transcript variant 3, mRNA.","division":"RefSeq","geneid":"90459","gi":"","length":"4463","nt_position":[],"snippet":"Data describe the structure of the nuclease domain of 3'-5'-exoribonuclease (3'hExo) complexed with rAMP in the presence of magnesium at 1.6 A resolution. REFERENCE 9 (bases 1 to 4463) AUTHORS Kennedy,S., Wang,D. and Ruvkun,G. TITLE A conserved siRNA-degrading RNase negatively regulates RNA interference in C. elegans JOURNAL Nature 427 (6975), 645-649 (2004) PUBMED 14961122 REMARK GeneRIF: molecular cloning; degrades siRNAs in vitro[ERI-1] REFERENCE 10 (bases 1 to 4463) AUTHORS Dominski,Z., Yang,X.C., Kaygun,H., Dadlez,M. and Marzluff,W.F. TITLE A 3' exonuclease that specifically interacts...","source":"Homo sapiens (human)","symbol":"ERI1","synonym":"3'HEXO; HEXO; HXAL; SEMDGC; SEMDGS; THEX1","version":"NM_001354635.2"},{"aa_position":[],"accession":"NM_001395689","definition":"Homo sapiens dicer 1, ribonuclease III (DICER1), transcript variant 18, mRNA.","division":"RefSeq","geneid":"23405","gi":"","length":"10253","nt_position":[],"snippet":"reference sequence was derived from AL356017.3 and AL390254.6. Summary: This gene encodes a protein possessing an RNA helicase motif containing a DEXH box in its amino terminus and an RNA motif in the carboxy terminus. The encoded protein functions as a ribonuclease and is required by the RNA interference and small temporal RNA (stRNA) pathways to produce the active small RNA component that represses gene expression. This protein also acts as a strong antiviral agent with activity against RNA viruses, including the Zika and SARS-CoV-2 viruses. Alternative splicing results in multiple...","source":"Homo sapiens (human)","symbol":"DICER1","synonym":"aviD; DCR1; Dicer; Dicer1e; GLOW; HERNA; K12H4.8-LIKE; MNG1; RMSE2","version":"NM_001395689.1"},{"aa_position":[],"accession":"NM_001395691","definition":"Homo sapiens dicer 1, ribonuclease III (DICER1), transcript variant 20, mRNA.","division":"RefSeq","geneid":"23405","gi":"","length":"10275","nt_position":[],"snippet":"reference sequence was derived from AL356017.3 and AL390254.6. Summary: This gene encodes a protein possessing an RNA helicase motif containing a DEXH box in its amino terminus and an RNA motif in the carboxy terminus. The encoded protein functions as a ribonuclease and is required by the RNA interference and small temporal RNA (stRNA) pathways to produce the active small RNA component that represses gene expression. This protein also acts as a strong antiviral agent with activity against RNA viruses, including the Zika and SARS-CoV-2 viruses. Alternative splicing results in multiple...","source":"Homo sapiens (human)","symbol":"DICER1","synonym":"aviD; DCR1; Dicer; Dicer1e; GLOW; HERNA; K12H4.8-LIKE; MNG1; RMSE2","version":"NM_001395691.1"},{"aa_position":[],"accession":"NM_030621","definition":"Homo sapiens dicer 1, ribonuclease III (DICER1), transcript variant 2, mRNA.","division":"RefSeq","geneid":"23405","gi":"","length":"10377","nt_position":[],"snippet":"On Apr 23, 2014 this sequence version replaced NM_030621.3. Summary: This gene encodes a protein possessing an RNA helicase motif containing a DEXH box in its amino terminus and an RNA motif in the carboxy terminus. The encoded protein functions as a ribonuclease and is required by the RNA interference and small temporal RNA (stRNA) pathways to produce the active small RNA component that represses gene expression. This protein also acts as a strong antiviral agent with activity against RNA viruses, including the Zika and SARS-CoV-2 viruses. Alternative splicing results in multiple transcript...","source":"Homo sapiens (human)","symbol":"DICER1","synonym":"aviD; DCR1; Dicer; Dicer1e; GLOW; HERNA; K12H4.8-LIKE; MNG1; RMSE2","version":"NM_030621.4"},{"aa_position":[],"accession":"NM_001395678","definition":"Homo sapiens dicer 1, ribonuclease III (DICER1), transcript variant 7, mRNA.","division":"RefSeq","geneid":"23405","gi":"","length":"10223","nt_position":[],"snippet":"On Jul 30, 2021 this sequence version replaced XM_017021121.2. Summary: This gene encodes a protein possessing an RNA helicase motif containing a DEXH box in its amino terminus and an RNA motif in the carboxy terminus. The encoded protein functions as a ribonuclease and is required by the RNA interference and small temporal RNA (stRNA) pathways to produce the active small RNA component that represses gene expression. This protein also acts as a strong antiviral agent with activity against RNA viruses, including the Zika and SARS-CoV-2 viruses. Alternative splicing results in multiple...","source":"Homo sapiens (human)","symbol":"DICER1","synonym":"aviD; DCR1; Dicer; Dicer1e; GLOW; HERNA; K12H4.8-LIKE; MNG1; RMSE2","version":"NM_001395678.1"},{"aa_position":[],"accession":"NM_001395697","definition":"Homo sapiens dicer 1, ribonuclease III (DICER1), transcript variant 27, mRNA.","division":"RefSeq","geneid":"23405","gi":"","length":"10436","nt_position":[],"snippet":"reference sequence was derived from AL356017.3 and AL390254.6. Summary: This gene encodes a protein possessing an RNA helicase motif containing a DEXH box in its amino terminus and an RNA motif in the carboxy terminus. The encoded protein functions as a ribonuclease and is required by the RNA interference and small temporal RNA (stRNA) pathways to produce the active small RNA component that represses gene expression. This protein also acts as a strong antiviral agent with activity against RNA viruses, including the Zika and SARS-CoV-2 viruses. Alternative splicing results in multiple...","source":"Homo sapiens (human)","symbol":"DICER1","synonym":"aviD; DCR1; Dicer; Dicer1e; GLOW; HERNA; K12H4.8-LIKE; MNG1; RMSE2","version":"NM_001395697.1"},{"aa_position":[],"accession":"NM_001395677","definition":"Homo sapiens dicer 1, ribonuclease III (DICER1), transcript variant 6, mRNA.","division":"RefSeq","geneid":"23405","gi":"","length":"10434","nt_position":[],"snippet":"reference sequence was derived from AL356017.3 and AL390254.6. Summary: This gene encodes a protein possessing an RNA helicase motif containing a DEXH box in its amino terminus and an RNA motif in the carboxy terminus. The encoded protein functions as a ribonuclease and is required by the RNA interference and small temporal RNA (stRNA) pathways to produce the active small RNA component that represses gene expression. This protein also acts as a strong antiviral agent with activity against RNA viruses, including the Zika and SARS-CoV-2 viruses. Alternative splicing results in multiple...","source":"Homo sapiens (human)","symbol":"DICER1","synonym":"aviD; DCR1; Dicer; Dicer1e; GLOW; HERNA; K12H4.8-LIKE; MNG1; RMSE2","version":"NM_001395677.1"},{"aa_position":[],"accession":"NM_001395688","definition":"Homo sapiens dicer 1, ribonuclease III (DICER1), transcript variant 17, mRNA.","division":"RefSeq","geneid":"23405","gi":"","length":"10420","nt_position":[],"snippet":"On Jul 30, 2021 this sequence version replaced XM_017021122.2. Summary: This gene encodes a protein possessing an RNA helicase motif containing a DEXH box in its amino terminus and an RNA motif in the carboxy terminus. The encoded protein functions as a ribonuclease and is required by the RNA interference and small temporal RNA (stRNA) pathways to produce the active small RNA component that represses gene expression. This protein also acts as a strong antiviral agent with activity against RNA viruses, including the Zika and SARS-CoV-2 viruses. Alternative splicing results in multiple...","source":"Homo sapiens (human)","symbol":"DICER1","synonym":"aviD; DCR1; Dicer; Dicer1e; GLOW; HERNA; K12H4.8-LIKE; MNG1; RMSE2","version":"NM_001395688.1"},{"aa_position":[],"accession":"NM_001395680","definition":"Homo sapiens dicer 1, ribonuclease III (DICER1), transcript variant 9, mRNA.","division":"RefSeq","geneid":"23405","gi":"","length":"10390","nt_position":[],"snippet":"this sequence version replaced NM_001395681.1, XM_011536600.3. Summary: This gene encodes a protein possessing an RNA helicase motif containing a DEXH box in its amino terminus and an RNA motif in the carboxy terminus. The encoded protein functions as a ribonuclease and is required by the RNA interference and small temporal RNA (stRNA) pathways to produce the active small RNA component that represses gene expression. This protein also acts as a strong antiviral agent with activity against RNA viruses, including the Zika and SARS-CoV-2 viruses. Alternative splicing results in multiple...","source":"Homo sapiens (human)","symbol":"DICER1","synonym":"aviD; DCR1; Dicer; Dicer1e; GLOW; HERNA; K12H4.8-LIKE; MNG1; RMSE2","version":"NM_001395680.1"},{"aa_position":[],"accession":"NM_001243953","definition":"Homo sapiens kinesin family member 2A (KIF2A), transcript variant 4, mRNA.","division":"RefSeq","geneid":"3796","gi":"","length":"7787","nt_position":[],"snippet":"appropriately at anaphase. REFERENCE 7 (bases 1 to 7787) AUTHORS Zhu,C., Zhao,J., Bibikova,M., Leverson,J.D., Bossy-Wetzel,E., Fan,J.B., Abraham,R.T. and Jiang,W. TITLE Functional analysis of human microtubule-based motor proteins, the kinesins and dyneins, in mitosis/cytokinesis using RNA interference JOURNAL Mol Biol Cell 16 (7), 3187-3199 (2005) PUBMED 15843429 REFERENCE 8 (bases 1 to 7787) AUTHORS Ganem,N.J. and Compton,D.A. TITLE The KinI kinesin Kif2a is required for bipolar spindle assembly through a functional relationship with MCAK JOURNAL J Cell Biol 166 (4), 473-478 (2004) PUBMED...","source":"Homo sapiens (human)","symbol":"KIF2A","synonym":"CDCBM3; HK2; KIF2","version":"NM_001243953.2"},{"aa_position":[],"accession":"NM_001395686","definition":"Homo sapiens dicer 1, ribonuclease III (DICER1), transcript variant 15, mRNA.","division":"RefSeq","geneid":"23405","gi":"","length":"10376","nt_position":[],"snippet":"reference sequence was derived from AL356017.3 and AL390254.6. Summary: This gene encodes a protein possessing an RNA helicase motif containing a DEXH box in its amino terminus and an RNA motif in the carboxy terminus. The encoded protein functions as a ribonuclease and is required by the RNA interference and small temporal RNA (stRNA) pathways to produce the active small RNA component that represses gene expression. This protein also acts as a strong antiviral agent with activity against RNA viruses, including the Zika and SARS-CoV-2 viruses. Alternative splicing results in multiple...","source":"Homo sapiens (human)","symbol":"DICER1","synonym":"aviD; DCR1; Dicer; Dicer1e; GLOW; HERNA; K12H4.8-LIKE; MNG1; RMSE2","version":"NM_001395686.1"},{"aa_position":[],"accession":"NM_001282662","definition":"Homo sapiens myocardin related transcription factor A (MRTFA), transcript variant 4, mRNA.","division":"RefSeq","geneid":"57591","gi":"","length":"4532","nt_position":[],"snippet":"for serum response factor (SRF), is required for serum induction of SRF target genes JOURNAL Mol Cell Biol 23 (18), 6597-6608 (2003) PUBMED 12944485 REMARK GeneRIF: Role of MKL1 in serum induction of c-fos and other SRE-regulated genes with a dominant negative MKL1 mutant (DN-MKL1) and RNA interference (RNAi) was assessed. DN-MKL1 and RNAi specifically blocked SRE-dependent reporter gene activation by serum and RhoA REFERENCE 8 (bases 1 to 4532) AUTHORS Ma,Z., Morris,S.W., Valentine,V., Li,M., Herbrick,J.A., Cui,X., Bouman,D., Li,Y., Mehta,P.K., Nizetic,D., Kaneko,Y., Chan,G.C., Chan,L.C.,...","source":"Homo sapiens (human)","symbol":"MRTFA","synonym":"BSAC; MAL; MKL; MKL1; MRTF-A","version":"NM_001282662.3"},{"aa_position":[],"accession":"NM_020831","definition":"Homo sapiens myocardin related transcription factor A (MRTFA), transcript variant 1, mRNA.","division":"RefSeq","geneid":"57591","gi":"","length":"4522","nt_position":[],"snippet":"for serum response factor (SRF), is required for serum induction of SRF target genes JOURNAL Mol Cell Biol 23 (18), 6597-6608 (2003) PUBMED 12944485 REMARK GeneRIF: Role of MKL1 in serum induction of c-fos and other SRE-regulated genes with a dominant negative MKL1 mutant (DN-MKL1) and RNA interference (RNAi) was assessed. DN-MKL1 and RNAi specifically blocked SRE-dependent reporter gene activation by serum and RhoA REFERENCE 8 (bases 1 to 4522) AUTHORS Ma,Z., Morris,S.W., Valentine,V., Li,M., Herbrick,J.A., Cui,X., Bouman,D., Li,Y., Mehta,P.K., Nizetic,D., Kaneko,Y., Chan,G.C., Chan,L.C.,...","source":"Homo sapiens (human)","symbol":"MRTFA","synonym":"BSAC; MAL; MKL; MKL1; MRTF-A","version":"NM_020831.6"},{"aa_position":[],"accession":"NM_153332","definition":"Homo sapiens exoribonuclease 1 (ERI1), transcript variant 1, mRNA.","division":"RefSeq","geneid":"90459","gi":"","length":"4521","nt_position":[],"snippet":"Data describe the structure of the nuclease domain of 3'-5'-exoribonuclease (3'hExo) complexed with rAMP in the presence of magnesium at 1.6 A resolution. REFERENCE 9 (bases 1 to 4521) AUTHORS Kennedy,S., Wang,D. and Ruvkun,G. TITLE A conserved siRNA-degrading RNase negatively regulates RNA interference in C. elegans JOURNAL Nature 427 (6975), 645-649 (2004) PUBMED 14961122 REMARK GeneRIF: molecular cloning; degrades siRNAs in vitro[ERI-1] REFERENCE 10 (bases 1 to 4521) AUTHORS Dominski,Z., Yang,X.C., Kaygun,H., Dadlez,M. and Marzluff,W.F. TITLE A 3' exonuclease that specifically interacts...","source":"Homo sapiens (human)","symbol":"ERI1","synonym":"3'HEXO; HEXO; HXAL; SEMDGC; SEMDGS; THEX1","version":"NM_153332.4"},{"aa_position":[],"accession":"NM_177438","definition":"Homo sapiens dicer 1, ribonuclease III (DICER1), transcript variant 1, mRNA.","division":"RefSeq","geneid":"23405","gi":"","length":"10384","nt_position":[],"snippet":"On Feb 25, 2020 this sequence version replaced NM_177438.2. Summary: This gene encodes a protein possessing an RNA helicase motif containing a DEXH box in its amino terminus and an RNA motif in the carboxy terminus. The encoded protein functions as a ribonuclease and is required by the RNA interference and small temporal RNA (stRNA) pathways to produce the active small RNA component that represses gene expression. This protein also acts as a strong antiviral agent with activity against RNA viruses, including the Zika and SARS-CoV-2 viruses. Alternative splicing results in multiple transcript...","source":"Homo sapiens (human)","symbol":"DICER1","synonym":"aviD; DCR1; Dicer; Dicer1e; GLOW; HERNA; K12H4.8-LIKE; MNG1; RMSE2","version":"NM_177438.3"},{"aa_position":[],"accession":"NM_001395683","definition":"Homo sapiens dicer 1, ribonuclease III (DICER1), transcript variant 12, mRNA.","division":"RefSeq","geneid":"23405","gi":"","length":"10485","nt_position":[],"snippet":"reference sequence was derived from AL356017.3 and AL390254.6. Summary: This gene encodes a protein possessing an RNA helicase motif containing a DEXH box in its amino terminus and an RNA motif in the carboxy terminus. The encoded protein functions as a ribonuclease and is required by the RNA interference and small temporal RNA (stRNA) pathways to produce the active small RNA component that represses gene expression. This protein also acts as a strong antiviral agent with activity against RNA viruses, including the Zika and SARS-CoV-2 viruses. Alternative splicing results in multiple...","source":"Homo sapiens (human)","symbol":"DICER1","synonym":"aviD; DCR1; Dicer; Dicer1e; GLOW; HERNA; K12H4.8-LIKE; MNG1; RMSE2","version":"NM_001395683.1"},{"aa_position":[],"accession":"NM_001395684","definition":"Homo sapiens dicer 1, ribonuclease III (DICER1), transcript variant 13, mRNA.","division":"RefSeq","geneid":"23405","gi":"","length":"10527","nt_position":[],"snippet":"reference sequence was derived from AL356017.3 and AL390254.6. Summary: This gene encodes a protein possessing an RNA helicase motif containing a DEXH box in its amino terminus and an RNA motif in the carboxy terminus. The encoded protein functions as a ribonuclease and is required by the RNA interference and small temporal RNA (stRNA) pathways to produce the active small RNA component that represses gene expression. This protein also acts as a strong antiviral agent with activity against RNA viruses, including the Zika and SARS-CoV-2 viruses. Alternative splicing results in multiple...","source":"Homo sapiens (human)","symbol":"DICER1","synonym":"aviD; DCR1; Dicer; Dicer1e; GLOW; HERNA; K12H4.8-LIKE; MNG1; RMSE2","version":"NM_001395684.1"},{"aa_position":[],"accession":"NM_001395679","definition":"Homo sapiens dicer 1, ribonuclease III (DICER1), transcript variant 8, mRNA.","division":"RefSeq","geneid":"23405","gi":"","length":"10551","nt_position":[],"snippet":"On Jul 30, 2021 this sequence version replaced XM_011536599.2. Summary: This gene encodes a protein possessing an RNA helicase motif containing a DEXH box in its amino terminus and an RNA motif in the carboxy terminus. The encoded protein functions as a ribonuclease and is required by the RNA interference and small temporal RNA (stRNA) pathways to produce the active small RNA component that represses gene expression. This protein also acts as a strong antiviral agent with activity against RNA viruses, including the Zika and SARS-CoV-2 viruses. Alternative splicing results in multiple...","source":"Homo sapiens (human)","symbol":"DICER1","synonym":"aviD; DCR1; Dicer; Dicer1e; GLOW; HERNA; K12H4.8-LIKE; MNG1; RMSE2","version":"NM_001395679.1"},{"aa_position":[],"accession":"NM_004520","definition":"Homo sapiens kinesin family member 2A (KIF2A), transcript variant 1, mRNA.","division":"RefSeq","geneid":"3796","gi":"","length":"7844","nt_position":[],"snippet":"appropriately at anaphase. REFERENCE 7 (bases 1 to 7844) AUTHORS Zhu,C., Zhao,J., Bibikova,M., Leverson,J.D., Bossy-Wetzel,E., Fan,J.B., Abraham,R.T. and Jiang,W. TITLE Functional analysis of human microtubule-based motor proteins, the kinesins and dyneins, in mitosis/cytokinesis using RNA interference JOURNAL Mol Biol Cell 16 (7), 3187-3199 (2005) PUBMED 15843429 REFERENCE 8 (bases 1 to 7844) AUTHORS Ganem,N.J. and Compton,D.A. TITLE The KinI kinesin Kif2a is required for bipolar spindle assembly through a functional relationship with MCAK JOURNAL J Cell Biol 166 (4), 473-478 (2004) PUBMED...","source":"Homo sapiens (human)","symbol":"KIF2A","synonym":"CDCBM3; HK2; KIF2","version":"NM_004520.5"},{"aa_position":[],"accession":"NM_001395682","definition":"Homo sapiens dicer 1, ribonuclease III (DICER1), transcript variant 11, mRNA.","division":"RefSeq","geneid":"23405","gi":"","length":"10694","nt_position":[],"snippet":"On Jul 30, 2021 this sequence version replaced XM_011536601.3. Summary: This gene encodes a protein possessing an RNA helicase motif containing a DEXH box in its amino terminus and an RNA motif in the carboxy terminus. The encoded protein functions as a ribonuclease and is required by the RNA interference and small temporal RNA (stRNA) pathways to produce the active small RNA component that represses gene expression. This protein also acts as a strong antiviral agent with activity against RNA viruses, including the Zika and SARS-CoV-2 viruses. Alternative splicing results in multiple...","source":"Homo sapiens (human)","symbol":"DICER1","synonym":"aviD; DCR1; Dicer; Dicer1e; GLOW; HERNA; K12H4.8-LIKE; MNG1; RMSE2","version":"NM_001395682.1"},{"aa_position":[],"accession":"NM_001098511","definition":"Homo sapiens kinesin family member 2A (KIF2A), transcript variant 2, mRNA.","division":"RefSeq","geneid":"3796","gi":"","length":"7958","nt_position":[],"snippet":"appropriately at anaphase. REFERENCE 7 (bases 1 to 7958) AUTHORS Zhu,C., Zhao,J., Bibikova,M., Leverson,J.D., Bossy-Wetzel,E., Fan,J.B., Abraham,R.T. and Jiang,W. TITLE Functional analysis of human microtubule-based motor proteins, the kinesins and dyneins, in mitosis/cytokinesis using RNA interference JOURNAL Mol Biol Cell 16 (7), 3187-3199 (2005) PUBMED 15843429 REFERENCE 8 (bases 1 to 7958) AUTHORS Ganem,N.J. and Compton,D.A. TITLE The KinI kinesin Kif2a is required for bipolar spindle assembly through a functional relationship with MCAK JOURNAL J Cell Biol 166 (4), 473-478 (2004) PUBMED...","source":"Homo sapiens (human)","symbol":"KIF2A","synonym":"CDCBM3; HK2; KIF2","version":"NM_001098511.3"},{"aa_position":[],"accession":"NM_001243952","definition":"Homo sapiens kinesin family member 2A (KIF2A), transcript variant 3, mRNA.","division":"RefSeq","geneid":"3796","gi":"","length":"8047","nt_position":[],"snippet":"appropriately at anaphase. REFERENCE 7 (bases 1 to 8047) AUTHORS Zhu,C., Zhao,J., Bibikova,M., Leverson,J.D., Bossy-Wetzel,E., Fan,J.B., Abraham,R.T. and Jiang,W. TITLE Functional analysis of human microtubule-based motor proteins, the kinesins and dyneins, in mitosis/cytokinesis using RNA interference JOURNAL Mol Biol Cell 16 (7), 3187-3199 (2005) PUBMED 15843429 REFERENCE 8 (bases 1 to 8047) AUTHORS Ganem,N.J. and Compton,D.A. TITLE The KinI kinesin Kif2a is required for bipolar spindle assembly through a functional relationship with MCAK JOURNAL J Cell Biol 166 (4), 473-478 (2004) PUBMED...","source":"Homo sapiens (human)","symbol":"KIF2A","synonym":"CDCBM3; HK2; KIF2","version":"NM_001243952.2"},{"aa_position":[],"accession":"NM_001134888","definition":"Homo sapiens retrotransposon Gag like 1 (RTL1), transcript variant 1, mRNA.","division":"RefSeq","geneid":"388015","gi":"","length":"5398","nt_position":[],"snippet":"retrotransposon-derived, paternally expressed imprinted gene that is highly expressed at the late fetal stage in both the fetus and placenta. It has an overlapping maternally expressed antisense transcript, which contains several microRNAs targeting the transcripts of this gene through an RNA interference (RNAi) mechanism. This gene is essential for maintenance of the fetal capillaries. [provided by RefSeq, Jul 2009]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##...","source":"Homo sapiens (human)","symbol":"RTL1","synonym":"HUR1; Mar1; MART1; PEG11; SIRH2","version":"NM_001134888.3"},{"aa_position":[],"accession":"NM_001395015","definition":"Homo sapiens coiled-coil domain containing 7 (CCDC7), transcript variant 6, mRNA.","division":"RefSeq","geneid":"79741","gi":"","length":"4826","nt_position":[],"snippet":"regular exercise JOURNAL Physiol Genomics 36 (2), 79-88 (2009) PUBMED 18984674 REMARK GeneRIF: Observational study of gene-disease association. (HuGE Navigator) REFERENCE 6 (bases 1 to 4826) AUTHORS Wang,C.T., Zhang,P., Wang,Y.S., Ruan,X.Z., Li,Z.Y., Peng,F., Yang,H.S. and Wei,Y.Q. TITLE RNA interference against Biot2, a novel mouse testis-specific gene, inhibits the growth of tumor cells JOURNAL Cell Mol Biol Lett 14 (3), 363-376 (2009) PUBMED 19277478 REFERENCE 7 (bases 1 to 4826) AUTHORS Grupe,A., Li,Y., Rowland,C., Nowotny,P., Hinrichs,A.L., Smemo,S., Kauwe,J.S., Maxwell,T.J., Cherny,S.,...","source":"Homo sapiens (human)","symbol":"CCDC7","synonym":"BIOT2; BioT2-A; BioT2-B; BioT2-C; C10orf68","version":"NM_001395015.1"},{"aa_position":[],"accession":"NM_001351850","definition":"Homo sapiens trinucleotide repeat containing adaptor 6A (TNRC6A), transcript variant 3, mRNA.","division":"RefSeq","geneid":"27327","gi":"","length":"8506","nt_position":[],"snippet":"sequence was derived from AC010321.8 and AC008731.8. On May 31, 2019 this sequence version replaced NM_001351850.1. Summary: This gene encodes a member of the trinucleotide repeat containing 6 protein family. The protein functions in post-transcriptional gene silencing through the RNA interference (RNAi) and microRNA pathways. The protein associates with messenger RNAs and Argonaute proteins in cytoplasmic bodies known as GW-bodies or P-bodies. Inhibiting expression of this gene delocalizes other GW-body proteins and impairs RNAi and microRNA-induced gene silencing....","source":"Homo sapiens (human)","symbol":"TNRC6A","synonym":"CAGH26; FAME6; GW1; GW182; TNRC6","version":"NM_001351850.2"},{"aa_position":[],"accession":"NM_001350722","definition":"Homo sapiens diacylglycerol kinase beta (DGKB), transcript variant 17, mRNA.","division":"RefSeq","geneid":"1607","gi":"","length":"6812","nt_position":[],"snippet":"AUTHORS Peiris,H., Park,S., Louis,S., Gu,X., Lam,J.Y., Asplund,O., Ippolito,G.C., Bottino,R., Groop,L., Tucker,H. and Kim,S.K. TITLE Discovering human diabetes-risk gene function with genetics and physiological assays JOURNAL Nat Commun 9 (1), 3855 (2018) PUBMED 30242153 REMARK GeneRIF: RNA interference-mediated knockdown of the Drosophila ortholog of DGKB in insulin-producing cells, a model for mammalian beta cells, conferred increased insulin output. Publication Status: Online-Only REFERENCE 4 (bases 1 to 6812) AUTHORS Tarnowski,M., Malinowski,D., Pawlak,K., Dziedziejko,V., Safranow,K. and...","source":"Homo sapiens (human)","symbol":"DGKB","synonym":"DAGK2; DGK; DGK-BETA","version":"NM_001350722.2"},{"aa_position":[],"accession":"NM_001350717","definition":"Homo sapiens diacylglycerol kinase beta (DGKB), transcript variant 12, mRNA.","division":"RefSeq","geneid":"1607","gi":"","length":"6811","nt_position":[],"snippet":"AUTHORS Peiris,H., Park,S., Louis,S., Gu,X., Lam,J.Y., Asplund,O., Ippolito,G.C., Bottino,R., Groop,L., Tucker,H. and Kim,S.K. TITLE Discovering human diabetes-risk gene function with genetics and physiological assays JOURNAL Nat Commun 9 (1), 3855 (2018) PUBMED 30242153 REMARK GeneRIF: RNA interference-mediated knockdown of the Drosophila ortholog of DGKB in insulin-producing cells, a model for mammalian beta cells, conferred increased insulin output. Publication Status: Online-Only REFERENCE 4 (bases 1 to 6811) AUTHORS Tarnowski,M., Malinowski,D., Pawlak,K., Dziedziejko,V., Safranow,K. and...","source":"Homo sapiens (human)","symbol":"DGKB","synonym":"DAGK2; DGK; DGK-BETA","version":"NM_001350717.2"},{"aa_position":[],"accession":"NM_001350721","definition":"Homo sapiens diacylglycerol kinase beta (DGKB), transcript variant 16, mRNA.","division":"RefSeq","geneid":"1607","gi":"","length":"6787","nt_position":[],"snippet":"AUTHORS Peiris,H., Park,S., Louis,S., Gu,X., Lam,J.Y., Asplund,O., Ippolito,G.C., Bottino,R., Groop,L., Tucker,H. and Kim,S.K. TITLE Discovering human diabetes-risk gene function with genetics and physiological assays JOURNAL Nat Commun 9 (1), 3855 (2018) PUBMED 30242153 REMARK GeneRIF: RNA interference-mediated knockdown of the Drosophila ortholog of DGKB in insulin-producing cells, a model for mammalian beta cells, conferred increased insulin output. Publication Status: Online-Only REFERENCE 4 (bases 1 to 6787) AUTHORS Tarnowski,M., Malinowski,D., Pawlak,K., Dziedziejko,V., Safranow,K. and...","source":"Homo sapiens (human)","symbol":"DGKB","synonym":"DAGK2; DGK; DGK-BETA","version":"NM_001350721.2"},{"aa_position":[],"accession":"NM_001350724","definition":"Homo sapiens diacylglycerol kinase beta (DGKB), transcript variant 19, mRNA.","division":"RefSeq","geneid":"1607","gi":"","length":"6785","nt_position":[],"snippet":"AUTHORS Peiris,H., Park,S., Louis,S., Gu,X., Lam,J.Y., Asplund,O., Ippolito,G.C., Bottino,R., Groop,L., Tucker,H. and Kim,S.K. TITLE Discovering human diabetes-risk gene function with genetics and physiological assays JOURNAL Nat Commun 9 (1), 3855 (2018) PUBMED 30242153 REMARK GeneRIF: RNA interference-mediated knockdown of the Drosophila ortholog of DGKB in insulin-producing cells, a model for mammalian beta cells, conferred increased insulin output. Publication Status: Online-Only REFERENCE 4 (bases 1 to 6785) AUTHORS Tarnowski,M., Malinowski,D., Pawlak,K., Dziedziejko,V., Safranow,K. and...","source":"Homo sapiens (human)","symbol":"DGKB","synonym":"DAGK2; DGK; DGK-BETA","version":"NM_001350724.2"},{"aa_position":[],"accession":"NM_001350711","definition":"Homo sapiens diacylglycerol kinase beta (DGKB), transcript variant 7, mRNA.","division":"RefSeq","geneid":"1607","gi":"","length":"6823","nt_position":[],"snippet":"AUTHORS Peiris,H., Park,S., Louis,S., Gu,X., Lam,J.Y., Asplund,O., Ippolito,G.C., Bottino,R., Groop,L., Tucker,H. and Kim,S.K. TITLE Discovering human diabetes-risk gene function with genetics and physiological assays JOURNAL Nat Commun 9 (1), 3855 (2018) PUBMED 30242153 REMARK GeneRIF: RNA interference-mediated knockdown of the Drosophila ortholog of DGKB in insulin-producing cells, a model for mammalian beta cells, conferred increased insulin output. Publication Status: Online-Only REFERENCE 4 (bases 1 to 6823) AUTHORS Tarnowski,M., Malinowski,D., Pawlak,K., Dziedziejko,V., Safranow,K. and...","source":"Homo sapiens (human)","symbol":"DGKB","synonym":"DAGK2; DGK; DGK-BETA","version":"NM_001350711.2"},{"aa_position":[],"accession":"NM_001350723","definition":"Homo sapiens diacylglycerol kinase beta (DGKB), transcript variant 18, mRNA.","division":"RefSeq","geneid":"1607","gi":"","length":"6809","nt_position":[],"snippet":"AUTHORS Peiris,H., Park,S., Louis,S., Gu,X., Lam,J.Y., Asplund,O., Ippolito,G.C., Bottino,R., Groop,L., Tucker,H. and Kim,S.K. TITLE Discovering human diabetes-risk gene function with genetics and physiological assays JOURNAL Nat Commun 9 (1), 3855 (2018) PUBMED 30242153 REMARK GeneRIF: RNA interference-mediated knockdown of the Drosophila ortholog of DGKB in insulin-producing cells, a model for mammalian beta cells, conferred increased insulin output. Publication Status: Online-Only REFERENCE 4 (bases 1 to 6809) AUTHORS Tarnowski,M., Malinowski,D., Pawlak,K., Dziedziejko,V., Safranow,K. and...","source":"Homo sapiens (human)","symbol":"DGKB","synonym":"DAGK2; DGK; DGK-BETA","version":"NM_001350723.2"},{"aa_position":[],"accession":"NM_001354636","definition":"Homo sapiens exoribonuclease 1 (ERI1), transcript variant 4, mRNA.","division":"RefSeq","geneid":"90459","gi":"","length":"4859","nt_position":[],"snippet":"Data describe the structure of the nuclease domain of 3'-5'-exoribonuclease (3'hExo) complexed with rAMP in the presence of magnesium at 1.6 A resolution. REFERENCE 9 (bases 1 to 4859) AUTHORS Kennedy,S., Wang,D. and Ruvkun,G. TITLE A conserved siRNA-degrading RNase negatively regulates RNA interference in C. elegans JOURNAL Nature 427 (6975), 645-649 (2004) PUBMED 14961122 REMARK GeneRIF: molecular cloning; degrades siRNAs in vitro[ERI-1] REFERENCE 10 (bases 1 to 4859) AUTHORS Dominski,Z., Yang,X.C., Kaygun,H., Dadlez,M. and Marzluff,W.F. TITLE A 3' exonuclease that specifically interacts...","source":"Homo sapiens (human)","symbol":"ERI1","synonym":"3'HEXO; HEXO; HXAL; SEMDGC; SEMDGS; THEX1","version":"NM_001354636.2"},{"aa_position":[],"accession":"NM_001350719","definition":"Homo sapiens diacylglycerol kinase beta (DGKB), transcript variant 14, mRNA.","division":"RefSeq","geneid":"1607","gi":"","length":"6808","nt_position":[],"snippet":"AUTHORS Peiris,H., Park,S., Louis,S., Gu,X., Lam,J.Y., Asplund,O., Ippolito,G.C., Bottino,R., Groop,L., Tucker,H. and Kim,S.K. TITLE Discovering human diabetes-risk gene function with genetics and physiological assays JOURNAL Nat Commun 9 (1), 3855 (2018) PUBMED 30242153 REMARK GeneRIF: RNA interference-mediated knockdown of the Drosophila ortholog of DGKB in insulin-producing cells, a model for mammalian beta cells, conferred increased insulin output. Publication Status: Online-Only REFERENCE 4 (bases 1 to 6808) AUTHORS Tarnowski,M., Malinowski,D., Pawlak,K., Dziedziejko,V., Safranow,K. and...","source":"Homo sapiens (human)","symbol":"DGKB","synonym":"DAGK2; DGK; DGK-BETA","version":"NM_001350719.2"},{"aa_position":[],"accession":"NM_001350707","definition":"Homo sapiens diacylglycerol kinase beta (DGKB), transcript variant 4, mRNA.","division":"RefSeq","geneid":"1607","gi":"","length":"6844","nt_position":[],"snippet":"AUTHORS Peiris,H., Park,S., Louis,S., Gu,X., Lam,J.Y., Asplund,O., Ippolito,G.C., Bottino,R., Groop,L., Tucker,H. and Kim,S.K. TITLE Discovering human diabetes-risk gene function with genetics and physiological assays JOURNAL Nat Commun 9 (1), 3855 (2018) PUBMED 30242153 REMARK GeneRIF: RNA interference-mediated knockdown of the Drosophila ortholog of DGKB in insulin-producing cells, a model for mammalian beta cells, conferred increased insulin output. Publication Status: Online-Only REFERENCE 4 (bases 1 to 6844) AUTHORS Tarnowski,M., Malinowski,D., Pawlak,K., Dziedziejko,V., Safranow,K. and...","source":"Homo sapiens (human)","symbol":"DGKB","synonym":"DAGK2; DGK; DGK-BETA","version":"NM_001350707.2"},{"aa_position":[],"accession":"NM_001321115","definition":"Homo sapiens coiled-coil domain containing 7 (CCDC7), transcript variant 5, mRNA.","division":"RefSeq","geneid":"79741","gi":"","length":"5060","nt_position":[],"snippet":"regular exercise JOURNAL Physiol Genomics 36 (2), 79-88 (2009) PUBMED 18984674 REMARK GeneRIF: Observational study of gene-disease association. (HuGE Navigator) REFERENCE 6 (bases 1 to 5060) AUTHORS Wang,C.T., Zhang,P., Wang,Y.S., Ruan,X.Z., Li,Z.Y., Peng,F., Yang,H.S. and Wei,Y.Q. TITLE RNA interference against Biot2, a novel mouse testis-specific gene, inhibits the growth of tumor cells JOURNAL Cell Mol Biol Lett 14 (3), 363-376 (2009) PUBMED 19277478 REFERENCE 7 (bases 1 to 5060) AUTHORS Grupe,A., Li,Y., Rowland,C., Nowotny,P., Hinrichs,A.L., Smemo,S., Kauwe,J.S., Maxwell,T.J., Cherny,S.,...","source":"Homo sapiens (human)","symbol":"CCDC7","synonym":"BIOT2; BioT2-A; BioT2-B; BioT2-C; C10orf68","version":"NM_001321115.2"},{"aa_position":[],"accession":"NM_001350714","definition":"Homo sapiens diacylglycerol kinase beta (DGKB), transcript variant 9, mRNA.","division":"RefSeq","geneid":"1607","gi":"","length":"6820","nt_position":[],"snippet":"AUTHORS Peiris,H., Park,S., Louis,S., Gu,X., Lam,J.Y., Asplund,O., Ippolito,G.C., Bottino,R., Groop,L., Tucker,H. and Kim,S.K. TITLE Discovering human diabetes-risk gene function with genetics and physiological assays JOURNAL Nat Commun 9 (1), 3855 (2018) PUBMED 30242153 REMARK GeneRIF: RNA interference-mediated knockdown of the Drosophila ortholog of DGKB in insulin-producing cells, a model for mammalian beta cells, conferred increased insulin output. Publication Status: Online-Only REFERENCE 4 (bases 1 to 6820) AUTHORS Tarnowski,M., Malinowski,D., Pawlak,K., Dziedziejko,V., Safranow,K. and...","source":"Homo sapiens (human)","symbol":"DGKB","synonym":"DAGK2; DGK; DGK-BETA","version":"NM_001350714.2"},{"aa_position":[],"accession":"NM_001350716","definition":"Homo sapiens diacylglycerol kinase beta (DGKB), transcript variant 11, mRNA.","division":"RefSeq","geneid":"1607","gi":"","length":"6823","nt_position":[],"snippet":"AUTHORS Peiris,H., Park,S., Louis,S., Gu,X., Lam,J.Y., Asplund,O., Ippolito,G.C., Bottino,R., Groop,L., Tucker,H. and Kim,S.K. TITLE Discovering human diabetes-risk gene function with genetics and physiological assays JOURNAL Nat Commun 9 (1), 3855 (2018) PUBMED 30242153 REMARK GeneRIF: RNA interference-mediated knockdown of the Drosophila ortholog of DGKB in insulin-producing cells, a model for mammalian beta cells, conferred increased insulin output. Publication Status: Online-Only REFERENCE 4 (bases 1 to 6823) AUTHORS Tarnowski,M., Malinowski,D., Pawlak,K., Dziedziejko,V., Safranow,K. and...","source":"Homo sapiens (human)","symbol":"DGKB","synonym":"DAGK2; DGK; DGK-BETA","version":"NM_001350716.2"},{"aa_position":[],"accession":"NM_001350706","definition":"Homo sapiens diacylglycerol kinase beta (DGKB), transcript variant 3, mRNA.","division":"RefSeq","geneid":"1607","gi":"","length":"6844","nt_position":[],"snippet":"AUTHORS Peiris,H., Park,S., Louis,S., Gu,X., Lam,J.Y., Asplund,O., Ippolito,G.C., Bottino,R., Groop,L., Tucker,H. and Kim,S.K. TITLE Discovering human diabetes-risk gene function with genetics and physiological assays JOURNAL Nat Commun 9 (1), 3855 (2018) PUBMED 30242153 REMARK GeneRIF: RNA interference-mediated knockdown of the Drosophila ortholog of DGKB in insulin-producing cells, a model for mammalian beta cells, conferred increased insulin output. Publication Status: Online-Only REFERENCE 4 (bases 1 to 6844) AUTHORS Tarnowski,M., Malinowski,D., Pawlak,K., Dziedziejko,V., Safranow,K. and...","source":"Homo sapiens (human)","symbol":"DGKB","synonym":"DAGK2; DGK; DGK-BETA","version":"NM_001350706.2"},{"aa_position":[],"accession":"NM_001350709","definition":"Homo sapiens diacylglycerol kinase beta (DGKB), transcript variant 6, mRNA.","division":"RefSeq","geneid":"1607","gi":"","length":"6841","nt_position":[],"snippet":"AUTHORS Peiris,H., Park,S., Louis,S., Gu,X., Lam,J.Y., Asplund,O., Ippolito,G.C., Bottino,R., Groop,L., Tucker,H. and Kim,S.K. TITLE Discovering human diabetes-risk gene function with genetics and physiological assays JOURNAL Nat Commun 9 (1), 3855 (2018) PUBMED 30242153 REMARK GeneRIF: RNA interference-mediated knockdown of the Drosophila ortholog of DGKB in insulin-producing cells, a model for mammalian beta cells, conferred increased insulin output. Publication Status: Online-Only REFERENCE 4 (bases 1 to 6841) AUTHORS Tarnowski,M., Malinowski,D., Pawlak,K., Dziedziejko,V., Safranow,K. and...","source":"Homo sapiens (human)","symbol":"DGKB","synonym":"DAGK2; DGK; DGK-BETA","version":"NM_001350709.2"},{"aa_position":[],"accession":"NM_001304743","definition":"Homo sapiens STE20 like kinase (SLK), transcript variant 2, mRNA.","division":"RefSeq","geneid":"9748","gi":"","length":"7734","nt_position":[],"snippet":"units and the extracellular matrix. REFERENCE 2 (bases 1 to 7734) AUTHORS Wang,K., Hong,R.L., Lu,J.B. and Wang,D.L. TITLE Ste20-like kinase is upregulated in glioma and induces glioma invasion JOURNAL Neoplasma 65 (2), 185-191 (2018) PUBMED 29534578 REMARK GeneRIF: The inhibition of SLK by RNA interference significantly suppressed the invasion ability of glioma, and on protein level, knock- down of SLK leaded to an up-regulation of E-cadherin and a down-regulation of Vimentin in glioma cells. REFERENCE 3 (bases 1 to 7734) AUTHORS Fokin,A.I., Klementeva,T.S., Nadezhdina,E.S. and Burakov,A.V....","source":"Homo sapiens (human)","symbol":"SLK","synonym":"bA16H23.1; LOSK; se20-9; STK2","version":"NM_001304743.2"},{"aa_position":[],"accession":"NM_001330520","definition":"Homo sapiens trinucleotide repeat containing adaptor 6A (TNRC6A), transcript variant 2, mRNA.","division":"RefSeq","geneid":"27327","gi":"","length":"8344","nt_position":[],"snippet":"was derived from AC002565.1, AC008731.8 and BU743266.1. On May 31, 2019 this sequence version replaced NM_001330520.2. Summary: This gene encodes a member of the trinucleotide repeat containing 6 protein family. The protein functions in post-transcriptional gene silencing through the RNA interference (RNAi) and microRNA pathways. The protein associates with messenger RNAs and Argonaute proteins in cytoplasmic bodies known as GW-bodies or P-bodies. Inhibiting expression of this gene delocalizes other GW-body proteins and impairs RNAi and microRNA-induced gene silencing....","source":"Homo sapiens (human)","symbol":"TNRC6A","synonym":"CAGH26; FAME6; GW1; GW182; TNRC6","version":"NM_001330520.3"},{"aa_position":[],"accession":"NM_014720","definition":"Homo sapiens STE20 like kinase (SLK), transcript variant 1, mRNA.","division":"RefSeq","geneid":"9748","gi":"","length":"7827","nt_position":[],"snippet":"units and the extracellular matrix. REFERENCE 2 (bases 1 to 7827) AUTHORS Wang,K., Hong,R.L., Lu,J.B. and Wang,D.L. TITLE Ste20-like kinase is upregulated in glioma and induces glioma invasion JOURNAL Neoplasma 65 (2), 185-191 (2018) PUBMED 29534578 REMARK GeneRIF: The inhibition of SLK by RNA interference significantly suppressed the invasion ability of glioma, and on protein level, knock- down of SLK leaded to an up-regulation of E-cadherin and a down-regulation of Vimentin in glioma cells. REFERENCE 3 (bases 1 to 7827) AUTHORS Fokin,A.I., Klementeva,T.S., Nadezhdina,E.S. and Burakov,A.V....","source":"Homo sapiens (human)","symbol":"SLK","synonym":"bA16H23.1; LOSK; se20-9; STK2","version":"NM_014720.4"},{"aa_position":[],"accession":"NM_014494","definition":"Homo sapiens trinucleotide repeat containing adaptor 6A (TNRC6A), transcript variant 1, mRNA.","division":"RefSeq","geneid":"27327","gi":"","length":"8491","nt_position":[],"snippet":"AC002565.1, BE158958.1, AJ492221.1, AC008731.8 and BU743266.1. On Nov 22, 2018 this sequence version replaced NM_014494.3. Summary: This gene encodes a member of the trinucleotide repeat containing 6 protein family. The protein functions in post-transcriptional gene silencing through the RNA interference (RNAi) and microRNA pathways. The protein associates with messenger RNAs and Argonaute proteins in cytoplasmic bodies known as GW-bodies or P-bodies. Inhibiting expression of this gene delocalizes other GW-body proteins and impairs RNAi and microRNA-induced gene silencing....","source":"Homo sapiens (human)","symbol":"TNRC6A","synonym":"CAGH26; FAME6; GW1; GW182; TNRC6","version":"NM_014494.4"},{"aa_position":[],"accession":"NM_001350720","definition":"Homo sapiens diacylglycerol kinase beta (DGKB), transcript variant 15, mRNA.","division":"RefSeq","geneid":"1607","gi":"","length":"7155","nt_position":[],"snippet":"AUTHORS Peiris,H., Park,S., Louis,S., Gu,X., Lam,J.Y., Asplund,O., Ippolito,G.C., Bottino,R., Groop,L., Tucker,H. and Kim,S.K. TITLE Discovering human diabetes-risk gene function with genetics and physiological assays JOURNAL Nat Commun 9 (1), 3855 (2018) PUBMED 30242153 REMARK GeneRIF: RNA interference-mediated knockdown of the Drosophila ortholog of DGKB in insulin-producing cells, a model for mammalian beta cells, conferred increased insulin output. Publication Status: Online-Only REFERENCE 4 (bases 1 to 7155) AUTHORS Tarnowski,M., Malinowski,D., Pawlak,K., Dziedziejko,V., Safranow,K. and...","source":"Homo sapiens (human)","symbol":"DGKB","synonym":"DAGK2; DGK; DGK-BETA","version":"NM_001350720.1"},{"aa_position":[],"accession":"NM_001350718","definition":"Homo sapiens diacylglycerol kinase beta (DGKB), transcript variant 13, mRNA.","division":"RefSeq","geneid":"1607","gi":"","length":"7176","nt_position":[],"snippet":"AUTHORS Peiris,H., Park,S., Louis,S., Gu,X., Lam,J.Y., Asplund,O., Ippolito,G.C., Bottino,R., Groop,L., Tucker,H. and Kim,S.K. TITLE Discovering human diabetes-risk gene function with genetics and physiological assays JOURNAL Nat Commun 9 (1), 3855 (2018) PUBMED 30242153 REMARK GeneRIF: RNA interference-mediated knockdown of the Drosophila ortholog of DGKB in insulin-producing cells, a model for mammalian beta cells, conferred increased insulin output. Publication Status: Online-Only REFERENCE 4 (bases 1 to 7176) AUTHORS Tarnowski,M., Malinowski,D., Pawlak,K., Dziedziejko,V., Safranow,K. and...","source":"Homo sapiens (human)","symbol":"DGKB","synonym":"DAGK2; DGK; DGK-BETA","version":"NM_001350718.1"},{"aa_position":[],"accession":"NM_001350712","definition":"Homo sapiens diacylglycerol kinase beta (DGKB), transcript variant 8, mRNA.","division":"RefSeq","geneid":"1607","gi":"","length":"7188","nt_position":[],"snippet":"AUTHORS Peiris,H., Park,S., Louis,S., Gu,X., Lam,J.Y., Asplund,O., Ippolito,G.C., Bottino,R., Groop,L., Tucker,H. and Kim,S.K. TITLE Discovering human diabetes-risk gene function with genetics and physiological assays JOURNAL Nat Commun 9 (1), 3855 (2018) PUBMED 30242153 REMARK GeneRIF: RNA interference-mediated knockdown of the Drosophila ortholog of DGKB in insulin-producing cells, a model for mammalian beta cells, conferred increased insulin output. Publication Status: Online-Only REFERENCE 4 (bases 1 to 7188) AUTHORS Tarnowski,M., Malinowski,D., Pawlak,K., Dziedziejko,V., Safranow,K. and...","source":"Homo sapiens (human)","symbol":"DGKB","synonym":"DAGK2; DGK; DGK-BETA","version":"NM_001350712.1"},{"aa_position":[],"accession":"NM_001350715","definition":"Homo sapiens diacylglycerol kinase beta (DGKB), transcript variant 10, mRNA.","division":"RefSeq","geneid":"1607","gi":"","length":"7191","nt_position":[],"snippet":"AUTHORS Peiris,H., Park,S., Louis,S., Gu,X., Lam,J.Y., Asplund,O., Ippolito,G.C., Bottino,R., Groop,L., Tucker,H. and Kim,S.K. TITLE Discovering human diabetes-risk gene function with genetics and physiological assays JOURNAL Nat Commun 9 (1), 3855 (2018) PUBMED 30242153 REMARK GeneRIF: RNA interference-mediated knockdown of the Drosophila ortholog of DGKB in insulin-producing cells, a model for mammalian beta cells, conferred increased insulin output. Publication Status: Online-Only REFERENCE 4 (bases 1 to 7191) AUTHORS Tarnowski,M., Malinowski,D., Pawlak,K., Dziedziejko,V., Safranow,K. and...","source":"Homo sapiens (human)","symbol":"DGKB","synonym":"DAGK2; DGK; DGK-BETA","version":"NM_001350715.1"},{"aa_position":[],"accession":"NM_001350708","definition":"Homo sapiens diacylglycerol kinase beta (DGKB), transcript variant 5, mRNA.","division":"RefSeq","geneid":"1607","gi":"","length":"7209","nt_position":[],"snippet":"AUTHORS Peiris,H., Park,S., Louis,S., Gu,X., Lam,J.Y., Asplund,O., Ippolito,G.C., Bottino,R., Groop,L., Tucker,H. and Kim,S.K. TITLE Discovering human diabetes-risk gene function with genetics and physiological assays JOURNAL Nat Commun 9 (1), 3855 (2018) PUBMED 30242153 REMARK GeneRIF: RNA interference-mediated knockdown of the Drosophila ortholog of DGKB in insulin-producing cells, a model for mammalian beta cells, conferred increased insulin output. Publication Status: Online-Only REFERENCE 4 (bases 1 to 7209) AUTHORS Tarnowski,M., Malinowski,D., Pawlak,K., Dziedziejko,V., Safranow,K. and...","source":"Homo sapiens (human)","symbol":"DGKB","synonym":"DAGK2; DGK; DGK-BETA","version":"NM_001350708.1"},{"aa_position":[],"accession":"NM_001350705","definition":"Homo sapiens diacylglycerol kinase beta (DGKB), transcript variant 1, mRNA.","division":"RefSeq","geneid":"1607","gi":"","length":"7212","nt_position":[],"snippet":"AUTHORS Peiris,H., Park,S., Louis,S., Gu,X., Lam,J.Y., Asplund,O., Ippolito,G.C., Bottino,R., Groop,L., Tucker,H. and Kim,S.K. TITLE Discovering human diabetes-risk gene function with genetics and physiological assays JOURNAL Nat Commun 9 (1), 3855 (2018) PUBMED 30242153 REMARK GeneRIF: RNA interference-mediated knockdown of the Drosophila ortholog of DGKB in insulin-producing cells, a model for mammalian beta cells, conferred increased insulin output. Publication Status: Online-Only REFERENCE 4 (bases 1 to 7212) AUTHORS Tarnowski,M., Malinowski,D., Pawlak,K., Dziedziejko,V., Safranow,K. and...","source":"Homo sapiens (human)","symbol":"DGKB","synonym":"DAGK2; DGK; DGK-BETA","version":"NM_001350705.1"},{"aa_position":[],"accession":"XM_017000526","definition":"PREDICTED: Homo sapiens argonaute RISC catalytic component 3 (AGO3), transcript variant X6, mRNA.","division":"RefSeq","geneid":"192669","gi":"","length":"18735","nt_position":[],"snippet":"misc_feature 100..441 /gene=\"AGO3\" /gene_synonym=\"EIF2C3\" /note=\"PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille; Region: PAZ_argonaute_like; cd02846\" /db_xref=\"CDD:239212\" misc_feature order(235..237,280..282,322..324,334..336,388..390, 409..411,415..417) /gene=\"AGO3\" /gene_synonym=\"EIF2C3\" /note=\"nucleic acid-binding interface [nucleotide binding]; other site\" /db_xref=\"CDD:239212\" misc_...","source":"Homo sapiens (human)","symbol":"AGO3","synonym":"EIF2C3","version":"XM_017000526.3"},{"aa_position":[],"accession":"NM_001313960","definition":"Homo sapiens ALF transcription elongation factor 1 (AFF1), transcript variant 4, mRNA.","division":"RefSeq","geneid":"4299","gi":"","length":"8090","nt_position":[],"snippet":"family have three conserved domains: an N-terminal homology domain, an AF4/ lymphoid nuclear protein domain, and a C-terminal homology domain. The protein functions as a regulator of RNA polymerase II-mediated transcription through elongation and chromatin remodeling functions. Through RNA interference screens, this gene has been shown to promote the expression of CD133, a plasma membrane glycoprotein required for leukemia cell survival. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2017]. Transcript Variant: This variant (4) contains a distinct 5' UTR...","source":"Homo sapiens (human)","symbol":"AFF1","synonym":"AF4; FEL; MLLT2; PBM1","version":"NM_001313960.2"},{"aa_position":[],"accession":"XM_047448134","definition":"PREDICTED: Homo sapiens argonaute RISC catalytic component 3 (AGO3), transcript variant X4, mRNA.","division":"RefSeq","geneid":"192669","gi":"","length":"19685","nt_position":[],"snippet":"misc_feature 1050..1391 /gene=\"AGO3\" /gene_synonym=\"EIF2C3\" /note=\"PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille; Region: PAZ_argonaute_like; cd02846\" /db_xref=\"CDD:239212\" misc_feature order(1185..1187,1230..1232,1272..1274,1284..1286, 1338..1340,1359..1361,1365..1367) /gene=\"AGO3\" /gene_synonym=\"EIF2C3\" /note=\"nucleic acid-binding interface [nucleotide binding]; other site\" /db_xref=\"CDD...","source":"Homo sapiens (human)","symbol":"AGO3","synonym":"EIF2C3","version":"XM_047448134.1"},{"aa_position":[],"accession":"XM_017000524","definition":"PREDICTED: Homo sapiens argonaute RISC catalytic component 3 (AGO3), transcript variant X5, mRNA.","division":"RefSeq","geneid":"192669","gi":"","length":"19690","nt_position":[],"snippet":"misc_feature 1055..1396 /gene=\"AGO3\" /gene_synonym=\"EIF2C3\" /note=\"PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille; Region: PAZ_argonaute_like; cd02846\" /db_xref=\"CDD:239212\" misc_feature order(1190..1192,1235..1237,1277..1279,1289..1291, 1343..1345,1364..1366,1370..1372) /gene=\"AGO3\" /gene_synonym=\"EIF2C3\" /note=\"nucleic acid-binding interface [nucleotide binding]; other site\" /db_xref=\"CDD...","source":"Homo sapiens (human)","symbol":"AGO3","synonym":"EIF2C3","version":"XM_017000524.3"},{"aa_position":[],"accession":"XM_011541236","definition":"PREDICTED: Homo sapiens argonaute RISC component 1 (AGO1), transcript variant X1, mRNA.","division":"RefSeq","geneid":"26523","gi":"","length":"13721","nt_position":[],"snippet":"pfam08699\" /db_xref=\"CDD:462567\" misc_feature 886..1248 /gene=\"AGO1\" /gene_synonym=\"EIF2C; EIF2C1; GERP95; hAgo1; NEDLBAS; Q99\" /note=\"PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille; Region: PAZ_argonaute_like; cd02846\" /db_xref=\"CDD:239212\" misc_feature order(1042..1044,1087..1089,1129..1131,1141..1143, 1195..1197,1216..1218,1222..1224) /gene=\"AGO1\" /gene_synonym=\"EIF2C; EIF2C1; GERP95;...","source":"Homo sapiens (human)","symbol":"AGO1","synonym":"EIF2C; EIF2C1; GERP95; hAgo1; NEDLBAS; Q99","version":"XM_011541236.3"},{"aa_position":[],"accession":"XM_005270575","definition":"PREDICTED: Homo sapiens argonaute RISC catalytic component 3 (AGO3), transcript variant X1, mRNA.","division":"RefSeq","geneid":"192669","gi":"","length":"19617","nt_position":[],"snippet":"linker 1 domain; Region: ArgoL1; pfam08699\" /db_xref=\"CDD:462567\" misc_feature 961..1323 /gene=\"AGO3\" /gene_synonym=\"EIF2C3\" /note=\"PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille; Region: PAZ_argonaute_like; cd02846\" /db_xref=\"CDD:239212\" misc_feature order(1117..1119,1162..1164,1204..1206,1216..1218, 1270..1272,1291..1293,1297..1299) /gene=\"AGO3\" /gene_synonym=\"EIF2C3\" /note=\"nucleic acid-...","source":"Homo sapiens (human)","symbol":"AGO3","synonym":"EIF2C3","version":"XM_005270575.5"},{"aa_position":[],"accession":"XM_017000523","definition":"PREDICTED: Homo sapiens argonaute RISC catalytic component 3 (AGO3), transcript variant X2, mRNA.","division":"RefSeq","geneid":"192669","gi":"","length":"19633","nt_position":[],"snippet":"linker 1 domain; Region: ArgoL1; pfam08699\" /db_xref=\"CDD:462567\" misc_feature 977..1339 /gene=\"AGO3\" /gene_synonym=\"EIF2C3\" /note=\"PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille; Region: PAZ_argonaute_like; cd02846\" /db_xref=\"CDD:239212\" misc_feature order(1133..1135,1178..1180,1220..1222,1232..1234, 1286..1288,1307..1309,1313..1315) /gene=\"AGO3\" /gene_synonym=\"EIF2C3\" /note=\"nucleic acid-...","source":"Homo sapiens (human)","symbol":"AGO3","synonym":"EIF2C3","version":"XM_017000523.3"},{"aa_position":[],"accession":"NM_032312","definition":"Homo sapiens Yip1 domain family member 4 (YIPF4), mRNA.","division":"RefSeq","geneid":"84272","gi":"","length":"11955","nt_position":[],"snippet":"Shields,D.C. and Simpson,J.C. TITLE Functional characterisation of the YIPF protein family in mammalian cells JOURNAL Histochem Cell Biol 147 (4), 439-451 (2017) PUBMED 274 REMARK GeneRIF: The significance of YIPF4 protein for the maintenance of the morphology of the Golgi was tested by RNA interference, revealing a number of specific morphological changes to this organelle on their depletion. REFERENCE 5 (bases 1 to 11955) AUTHORS Muller,M., Wasson,C.W., Bhatia,R., Boxall,S., Millan,D., Goh,G.Y., Haas,J., Stonehouse,N.J. and Macdonald,A. TITLE YIP1 family member 4 (YIPF4) is a novel cellular...","source":"Homo sapiens (human)","symbol":"YIPF4","synonym":"FinGER4; Nbla11189; YIPFalpha2","version":"NM_032312.4"},{"aa_position":[],"accession":"XM_011516968","definition":"PREDICTED: Homo sapiens argonaute RISC catalytic component 2 (AGO2), transcript variant X5, mRNA.","division":"RefSeq","geneid":"27161","gi":"","length":"14567","nt_position":[],"snippet":"pfam08699\" /db_xref=\"CDD:462567\" misc_feature 778..1140 /gene=\"AGO2\" /gene_synonym=\"CASC7; EIF2C2; LESKRES; LINC00980; PPD; Q10\" /note=\"PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille; Region: PAZ_argonaute_like; cd02846\" /db_xref=\"CDD:239212\" misc_feature order(934..936,979..981,1021..1023,1033..1035,1087..1089, 1108..1110,1114..1116) /gene=\"AGO2\" /gene_synonym=\"CASC7; EIF2C2; LESKRES;...","source":"Homo sapiens (human)","symbol":"AGO2","synonym":"CASC7; EIF2C2; LESKRES; LINC00980; PPD; Q10","version":"XM_011516968.3"},{"aa_position":[],"accession":"XM_011516965","definition":"PREDICTED: Homo sapiens argonaute RISC catalytic component 2 (AGO2), transcript variant X1, mRNA.","division":"RefSeq","geneid":"27161","gi":"","length":"14779","nt_position":[],"snippet":"pfam08699\" /db_xref=\"CDD:462567\" misc_feature 990..1352 /gene=\"AGO2\" /gene_synonym=\"CASC7; EIF2C2; LESKRES; LINC00980; PPD; Q10\" /note=\"PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille; Region: PAZ_argonaute_like; cd02846\" /db_xref=\"CDD:239212\" misc_feature order(1146..1148,1191..1193,1233..1235,1245..1247, 1299..1301,1320..1322,1326..1328) /gene=\"AGO2\" /gene_synonym=\"CASC7; EIF2C2; LESKRES;...","source":"Homo sapiens (human)","symbol":"AGO2","synonym":"CASC7; EIF2C2; LESKRES; LINC00980; PPD; Q10","version":"XM_011516965.3"},{"aa_position":[],"accession":"XM_047421697","definition":"PREDICTED: Homo sapiens argonaute RISC catalytic component 2 (AGO2), transcript variant X4, mRNA.","division":"RefSeq","geneid":"27161","gi":"","length":"14713","nt_position":[],"snippet":"pfam08699\" /db_xref=\"CDD:462567\" misc_feature 924..1286 /gene=\"AGO2\" /gene_synonym=\"CASC7; EIF2C2; LESKRES; LINC00980; PPD; Q10\" /note=\"PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille; Region: PAZ_argonaute_like; cd02846\" /db_xref=\"CDD:239212\" misc_feature order(1080..1082,1125..1127,1167..1169,1179..1181, 1233..1235,1254..1256,1260..1262) /gene=\"AGO2\" /gene_synonym=\"CASC7; EIF2C2; LESKRES;...","source":"Homo sapiens (human)","symbol":"AGO2","synonym":"CASC7; EIF2C2; LESKRES; LINC00980; PPD; Q10","version":"XM_047421697.1"},{"aa_position":[],"accession":"XM_011540879","definition":"PREDICTED: Homo sapiens argonaute RISC catalytic component 3 (AGO3), transcript variant X3, mRNA.","division":"RefSeq","geneid":"192669","gi":"","length":"20771","nt_position":[],"snippet":"linker 1 domain; Region: ArgoL1; pfam08699\" /db_xref=\"CDD:462567\" misc_feature 2115..2477 /gene=\"AGO3\" /gene_synonym=\"EIF2C3\" /note=\"PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille; Region: PAZ_argonaute_like; cd02846\" /db_xref=\"CDD:239212\" misc_feature order(2271..2273,2316..2318,2358..2360,2370..2372, 2424..2426,2445..2447,2451..2453) /gene=\"AGO3\" /gene_synonym=\"EIF2C3\" /note=\"nucleic acid...","source":"Homo sapiens (human)","symbol":"AGO3","synonym":"EIF2C3","version":"XM_011540879.4"},{"aa_position":[],"accession":"NM_006977","definition":"Homo sapiens zinc finger and BTB domain containing 25 (ZBTB25), transcript variant 2, mRNA.","division":"RefSeq","geneid":"7597","gi":"","length":"10365","nt_position":[],"snippet":"differentiation, and lineage-specific transcription factors including ZBTB25 as a novel NF-AT repressor JOURNAL Blood 115 (26), 5376-5384 (2010) PUBMED 20410506 REMARK GeneRIF: ZBTB25 functions as a negative regulator of nuclear factor of activated T cells (NF-AT) activation, such that RNA interference mediated knockdown resulted in enhanced activation of target genes. REFERENCE 8 (bases 1 to 10365) AUTHORS Ravasi,T., Suzuki,H., Cannistraci,C.V., Katayama,S., Bajic,V.B., Tan,K., Akalin,A., Schmeier,S., Kanamori-Katayama,M., Bertin,N., Carninci,P., Daub,C.O., Forrest,A.R., Gough,J., Grimmond,S...","source":"Homo sapiens (human)","symbol":"ZBTB25","synonym":"C14orf51; KUP; ZNF46","version":"NM_006977.5"},{"aa_position":[],"accession":"NM_001354687","definition":"Homo sapiens zinc finger and BTB domain containing 25 (ZBTB25), transcript variant 9, mRNA.","division":"RefSeq","geneid":"7597","gi":"","length":"10564","nt_position":[],"snippet":"differentiation, and lineage-specific transcription factors including ZBTB25 as a novel NF-AT repressor JOURNAL Blood 115 (26), 5376-5384 (2010) PUBMED 20410506 REMARK GeneRIF: ZBTB25 functions as a negative regulator of nuclear factor of activated T cells (NF-AT) activation, such that RNA interference mediated knockdown resulted in enhanced activation of target genes. REFERENCE 8 (bases 1 to 10564) AUTHORS Ravasi,T., Suzuki,H., Cannistraci,C.V., Katayama,S., Bajic,V.B., Tan,K., Akalin,A., Schmeier,S., Kanamori-Katayama,M., Bertin,N., Carninci,P., Daub,C.O., Forrest,A.R., Gough,J., Grimmond,S...","source":"Homo sapiens (human)","symbol":"ZBTB25","synonym":"C14orf51; KUP; ZNF46","version":"NM_001354687.2"},{"aa_position":[],"accession":"NM_153252","definition":"Homo sapiens bromodomain and WD repeat domain containing 3 (BRWD3), transcript variant 1, mRNA.","division":"RefSeq","geneid":"254065","gi":"","length":"12921","nt_position":[],"snippet":"and may cause disease by altering intracellular signaling pathways affecting cellular proliferation. REFERENCE 9 (bases 1 to 12921) AUTHORS Muller,P., Kuttenkeuler,D., Gesellchen,V., Zeidler,M.P. and Boutros,M. TITLE Identification of JAK/STAT signalling components by genome-wide RNA interference JOURNAL Nature 436 (7052), 871-875 (2005) PUBMED 16094372 REFERENCE 10 (bases 1 to 12921) AUTHORS Kalla,C., Nentwich,H., Schlotter,M., Mertens,D., Wildenberger,K., Dohner,H., Stilgenbauer,S. and Lichter,P. TITLE Translocation t(X;11)(q13;q23) in B-cell chronic lymphocytic leukemia disrupts two novel...","source":"Homo sapiens (human)","symbol":"BRWD3","synonym":"BRODL; DCAF20; MRX93; XLID93","version":"NM_153252.5"},{"aa_position":[],"accession":"NM_005935","definition":"Homo sapiens ALF transcription elongation factor 1 (AFF1), transcript variant 2, mRNA.","division":"RefSeq","geneid":"4299","gi":"","length":"9108","nt_position":[],"snippet":"family have three conserved domains: an N-terminal homology domain, an AF4/ lymphoid nuclear protein domain, and a C-terminal homology domain. The protein functions as a regulator of RNA polymerase II-mediated transcription through elongation and chromatin remodeling functions. Through RNA interference screens, this gene has been shown to promote the expression of CD133, a plasma membrane glycoprotein required for leukemia cell survival. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2017]. Transcript Variant: This variant (2) contains a distinct 5' UTR...","source":"Homo sapiens (human)","symbol":"AFF1","synonym":"AF4; FEL; MLLT2; PBM1","version":"NM_005935.4"},{"aa_position":[],"accession":"NM_001313959","definition":"Homo sapiens ALF transcription elongation factor 1 (AFF1), transcript variant 3, mRNA.","division":"RefSeq","geneid":"4299","gi":"","length":"9111","nt_position":[],"snippet":"family have three conserved domains: an N-terminal homology domain, an AF4/ lymphoid nuclear protein domain, and a C-terminal homology domain. The protein functions as a regulator of RNA polymerase II-mediated transcription through elongation and chromatin remodeling functions. Through RNA interference screens, this gene has been shown to promote the expression of CD133, a plasma membrane glycoprotein required for leukemia cell survival. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2017]. Transcript Variant: This variant (3) contains a distinct 5' UTR...","source":"Homo sapiens (human)","symbol":"AFF1","synonym":"AF4; FEL; MLLT2; PBM1","version":"NM_001313959.2"},{"aa_position":[],"accession":"NM_001166693","definition":"Homo sapiens ALF transcription elongation factor 1 (AFF1), transcript variant 1, mRNA.","division":"RefSeq","geneid":"4299","gi":"","length":"9261","nt_position":[],"snippet":"family have three conserved domains: an N-terminal homology domain, an AF4/ lymphoid nuclear protein domain, and a C-terminal homology domain. The protein functions as a regulator of RNA polymerase II-mediated transcription through elongation and chromatin remodeling functions. Through RNA interference screens, this gene has been shown to promote the expression of CD133, a plasma membrane glycoprotein required for leukemia cell survival. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2017]. Transcript Variant: This variant (1) encodes the longest isoform...","source":"Homo sapiens (human)","symbol":"AFF1","synonym":"AF4; FEL; MLLT2; PBM1","version":"NM_001166693.3"},{"aa_position":[],"accession":"NM_001354685","definition":"Homo sapiens zinc finger and BTB domain containing 25 (ZBTB25), transcript variant 7, mRNA.","division":"RefSeq","geneid":"7597","gi":"","length":"10909","nt_position":[],"snippet":"differentiation, and lineage-specific transcription factors including ZBTB25 as a novel NF-AT repressor JOURNAL Blood 115 (26), 5376-5384 (2010) PUBMED 20410506 REMARK GeneRIF: ZBTB25 functions as a negative regulator of nuclear factor of activated T cells (NF-AT) activation, such that RNA interference mediated knockdown resulted in enhanced activation of target genes. REFERENCE 8 (bases 1 to 10909) AUTHORS Ravasi,T., Suzuki,H., Cannistraci,C.V., Katayama,S., Bajic,V.B., Tan,K., Akalin,A., Schmeier,S., Kanamori-Katayama,M., Bertin,N., Carninci,P., Daub,C.O., Forrest,A.R., Gough,J., Grimmond,S...","source":"Homo sapiens (human)","symbol":"ZBTB25","synonym":"C14orf51; KUP; ZNF46","version":"NM_001354685.2"},{"aa_position":[],"accession":"NM_001354684","definition":"Homo sapiens zinc finger and BTB domain containing 25 (ZBTB25), transcript variant 6, mRNA.","division":"RefSeq","geneid":"7597","gi":"","length":"11517","nt_position":[],"snippet":"differentiation, and lineage-specific transcription factors including ZBTB25 as a novel NF-AT repressor JOURNAL Blood 115 (26), 5376-5384 (2010) PUBMED 20410506 REMARK GeneRIF: ZBTB25 functions as a negative regulator of nuclear factor of activated T cells (NF-AT) activation, such that RNA interference mediated knockdown resulted in enhanced activation of target genes. REFERENCE 8 (bases 1 to 11517) AUTHORS Ravasi,T., Suzuki,H., Cannistraci,C.V., Katayama,S., Bajic,V.B., Tan,K., Akalin,A., Schmeier,S., Kanamori-Katayama,M., Bertin,N., Carninci,P., Daub,C.O., Forrest,A.R., Gough,J., Grimmond,S...","source":"Homo sapiens (human)","symbol":"ZBTB25","synonym":"C14orf51; KUP; ZNF46","version":"NM_001354684.2"},{"aa_position":[],"accession":"NM_001354682","definition":"Homo sapiens zinc finger and BTB domain containing 25 (ZBTB25), transcript variant 4, mRNA.","division":"RefSeq","geneid":"7597","gi":"","length":"10822","nt_position":[],"snippet":"differentiation, and lineage-specific transcription factors including ZBTB25 as a novel NF-AT repressor JOURNAL Blood 115 (26), 5376-5384 (2010) PUBMED 20410506 REMARK GeneRIF: ZBTB25 functions as a negative regulator of nuclear factor of activated T cells (NF-AT) activation, such that RNA interference mediated knockdown resulted in enhanced activation of target genes. REFERENCE 8 (bases 1 to 10822) AUTHORS Ravasi,T., Suzuki,H., Cannistraci,C.V., Katayama,S., Bajic,V.B., Tan,K., Akalin,A., Schmeier,S., Kanamori-Katayama,M., Bertin,N., Carninci,P., Daub,C.O., Forrest,A.R., Gough,J., Grimmond,S...","source":"Homo sapiens (human)","symbol":"ZBTB25","synonym":"C14orf51; KUP; ZNF46","version":"NM_001354682.2"},{"aa_position":[],"accession":"NM_001354686","definition":"Homo sapiens zinc finger and BTB domain containing 25 (ZBTB25), transcript variant 8, mRNA.","division":"RefSeq","geneid":"7597","gi":"","length":"11108","nt_position":[],"snippet":"differentiation, and lineage-specific transcription factors including ZBTB25 as a novel NF-AT repressor JOURNAL Blood 115 (26), 5376-5384 (2010) PUBMED 20410506 REMARK GeneRIF: ZBTB25 functions as a negative regulator of nuclear factor of activated T cells (NF-AT) activation, such that RNA interference mediated knockdown resulted in enhanced activation of target genes. REFERENCE 8 (bases 1 to 11108) AUTHORS Ravasi,T., Suzuki,H., Cannistraci,C.V., Katayama,S., Bajic,V.B., Tan,K., Akalin,A., Schmeier,S., Kanamori-Katayama,M., Bertin,N., Carninci,P., Daub,C.O., Forrest,A.R., Gough,J., Grimmond,S...","source":"Homo sapiens (human)","symbol":"ZBTB25","synonym":"C14orf51; KUP; ZNF46","version":"NM_001354686.2"},{"aa_position":[],"accession":"XM_047421696","definition":"PREDICTED: Homo sapiens argonaute RISC catalytic component 2 (AGO2), transcript variant X3, mRNA.","division":"RefSeq","geneid":"27161","gi":"","length":"17159","nt_position":[],"snippet":"pfam08699\" /db_xref=\"CDD:462567\" misc_feature 3370..3732 /gene=\"AGO2\" /gene_synonym=\"CASC7; EIF2C2; LESKRES; LINC00980; PPD; Q10\" /note=\"PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille; Region: PAZ_argonaute_like; cd02846\" /db_xref=\"CDD:239212\" misc_feature order(3526..3528,3571..3573,3613..3615,3625..3627, 3679..3681,3700..3702,3706..3708) /gene=\"AGO2\" /gene_synonym=\"CASC7; EIF2C2; LESKRES...","source":"Homo sapiens (human)","symbol":"AGO2","synonym":"CASC7; EIF2C2; LESKRES; LINC00980; PPD; Q10","version":"XM_047421696.1"},{"aa_position":[],"accession":"NR_172715","definition":"Homo sapiens dicer 1, ribonuclease III (DICER1), transcript variant 31, non-coding RNA.","division":"RefSeq","geneid":"23405","gi":"","length":"7334","nt_position":[],"snippet":"reference sequence was derived from AL356017.3 and AL390254.6. Summary: This gene encodes a protein possessing an RNA helicase motif containing a DEXH box in its amino terminus and an RNA motif in the carboxy terminus. The encoded protein functions as a ribonuclease and is required by the RNA interference and small temporal RNA (stRNA) pathways to produce the active small RNA component that represses gene expression. This protein also acts as a strong antiviral agent with activity against RNA viruses, including the Zika and SARS-CoV-2 viruses. Alternative splicing results in multiple...","source":"Homo sapiens (human)","symbol":"DICER1","synonym":"aviD; DCR1; Dicer; Dicer1e; GLOW; HERNA; K12H4.8-LIKE; MNG1; RMSE2","version":"NR_172715.1"},{"aa_position":[],"accession":"NR_172717","definition":"Homo sapiens dicer 1, ribonuclease III (DICER1), transcript variant 33, non-coding RNA.","division":"RefSeq","geneid":"23405","gi":"","length":"7428","nt_position":[],"snippet":"reference sequence was derived from AL356017.3 and AL390254.6. Summary: This gene encodes a protein possessing an RNA helicase motif containing a DEXH box in its amino terminus and an RNA motif in the carboxy terminus. The encoded protein functions as a ribonuclease and is required by the RNA interference and small temporal RNA (stRNA) pathways to produce the active small RNA component that represses gene expression. This protein also acts as a strong antiviral agent with activity against RNA viruses, including the Zika and SARS-CoV-2 viruses. Alternative splicing results in multiple...","source":"Homo sapiens (human)","symbol":"DICER1","synonym":"aviD; DCR1; Dicer; Dicer1e; GLOW; HERNA; K12H4.8-LIKE; MNG1; RMSE2","version":"NR_172717.1"},{"aa_position":[],"accession":"NR_172719","definition":"Homo sapiens dicer 1, ribonuclease III (DICER1), transcript variant 35, non-coding RNA.","division":"RefSeq","geneid":"23405","gi":"","length":"10307","nt_position":[],"snippet":"reference sequence was derived from AL356017.3 and AL390254.6. Summary: This gene encodes a protein possessing an RNA helicase motif containing a DEXH box in its amino terminus and an RNA motif in the carboxy terminus. The encoded protein functions as a ribonuclease and is required by the RNA interference and small temporal RNA (stRNA) pathways to produce the active small RNA component that represses gene expression. This protein also acts as a strong antiviral agent with activity against RNA viruses, including the Zika and SARS-CoV-2 viruses. Alternative splicing results in multiple...","source":"Homo sapiens (human)","symbol":"DICER1","synonym":"aviD; DCR1; Dicer; Dicer1e; GLOW; HERNA; K12H4.8-LIKE; MNG1; RMSE2","version":"NR_172719.1"},{"aa_position":[],"accession":"NR_172718","definition":"Homo sapiens dicer 1, ribonuclease III (DICER1), transcript variant 34, non-coding RNA.","division":"RefSeq","geneid":"23405","gi":"","length":"10474","nt_position":[],"snippet":"reference sequence was derived from AL356017.3 and AL390254.6. Summary: This gene encodes a protein possessing an RNA helicase motif containing a DEXH box in its amino terminus and an RNA motif in the carboxy terminus. The encoded protein functions as a ribonuclease and is required by the RNA interference and small temporal RNA (stRNA) pathways to produce the active small RNA component that represses gene expression. This protein also acts as a strong antiviral agent with activity against RNA viruses, including the Zika and SARS-CoV-2 viruses. Alternative splicing results in multiple...","source":"Homo sapiens (human)","symbol":"DICER1","synonym":"aviD; DCR1; Dicer; Dicer1e; GLOW; HERNA; K12H4.8-LIKE; MNG1; RMSE2","version":"NR_172718.1"},{"aa_position":[],"accession":"NR_172720","definition":"Homo sapiens dicer 1, ribonuclease III (DICER1), transcript variant 36, non-coding RNA.","division":"RefSeq","geneid":"23405","gi":"","length":"10510","nt_position":[],"snippet":"reference sequence was derived from AL356017.3 and AL390254.6. Summary: This gene encodes a protein possessing an RNA helicase motif containing a DEXH box in its amino terminus and an RNA motif in the carboxy terminus. The encoded protein functions as a ribonuclease and is required by the RNA interference and small temporal RNA (stRNA) pathways to produce the active small RNA component that represses gene expression. This protein also acts as a strong antiviral agent with activity against RNA viruses, including the Zika and SARS-CoV-2 viruses. Alternative splicing results in multiple...","source":"Homo sapiens (human)","symbol":"DICER1","synonym":"aviD; DCR1; Dicer; Dicer1e; GLOW; HERNA; K12H4.8-LIKE; MNG1; RMSE2","version":"NR_172720.1"},{"aa_position":[],"accession":"NR_172716","definition":"Homo sapiens dicer 1, ribonuclease III (DICER1), transcript variant 32, non-coding RNA.","division":"RefSeq","geneid":"23405","gi":"","length":"10641","nt_position":[],"snippet":"reference sequence was derived from AL356017.3 and AL390254.6. Summary: This gene encodes a protein possessing an RNA helicase motif containing a DEXH box in its amino terminus and an RNA motif in the carboxy terminus. The encoded protein functions as a ribonuclease and is required by the RNA interference and small temporal RNA (stRNA) pathways to produce the active small RNA component that represses gene expression. This protein also acts as a strong antiviral agent with activity against RNA viruses, including the Zika and SARS-CoV-2 viruses. Alternative splicing results in multiple...","source":"Homo sapiens (human)","symbol":"DICER1","synonym":"aviD; DCR1; Dicer; Dicer1e; GLOW; HERNA; K12H4.8-LIKE; MNG1; RMSE2","version":"NR_172716.1"}],"summary":[{"count":322,"keyword":"RNA interference"},{"count":322,"keyword":"[INTERSECTION]"}],"time":"2026-05-13 07:05:44","version":"GGRNA.v2 : RefSeq release 233 (Jan, 2026)"}