LOCUS       NM_001259385            7888 bp    mRNA    linear   INV 26-DEC-2023
DEFINITION  Drosophila melanogaster Argonaute-1 (AGO1), transcript variant D,
            mRNA.
ACCESSION   NM_001259385
VERSION     NM_001259385.1
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 7888)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7888)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7888)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 7888)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 7888)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 7888)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 7888)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 7888)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 7888)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 7888)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 7888)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 7888)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 7888)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 7888)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 7888)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 7888)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 7888)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 7888)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 7888)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 7888)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-OCT-2015) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   21 (bases 1 to 7888)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 7888)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   23 (bases 1 to 7888)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   24 (bases 1 to 7888)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NT_033778).
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..7888
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="2R"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..7888
                     /gene="AGO1"
                     /locus_tag="Dmel_CG6671"
                     /gene_synonym="Ago; ago-1; Ago-1; AGO-1; ago1; Ago1;
                     ago1-1; Agp1; anon-WO0257455.29; argonaute1; CG6671;
                     dAgo1; dAGO1; Dm Ago1; dmAgo1; DmAgo1; Dmel\CG6671;
                     l(2)04845; l(2)4845; l(2)k00208; l(2)k08121; MRE20"
                     /note="Argonaute-1"
                     /map="50C9-50C17"
                     /db_xref="FLYBASE:FBgn0262739"
                     /db_xref="GeneID:36544"
     CDS             349..3303
                     /gene="AGO1"
                     /locus_tag="Dmel_CG6671"
                     /gene_synonym="Ago; ago-1; Ago-1; AGO-1; ago1; Ago1;
                     ago1-1; Agp1; anon-WO0257455.29; argonaute1; CG6671;
                     dAgo1; dAGO1; Dm Ago1; dmAgo1; DmAgo1; Dmel\CG6671;
                     l(2)04845; l(2)4845; l(2)k00208; l(2)k08121; MRE20"
                     /note="CG6671 gene product from transcript CG6671-RD;
                     CG6671-PD; AGO1-PD; argonaute-1; argonaute protein 1;
                     Argonaute1; mRNA-like ncRNA in embryogenesis 20; argonaute
                     1"
                     /codon_start=1
                     /product="Argonaute-1, isoform D"
                     /protein_id="NP_001246314.1"
                     /db_xref="FLYBASE:FBpp0294043"
                     /db_xref="GeneID:36544"
                     /db_xref="FLYBASE:FBgn0262739"
                     /translation="

MSTERELAPGGPAQLHPHTLPLTFPDLQMTSTVGIIGKVYESQWTPSPTRPQSPSQAQTSFDTLTSPPAPGSSVNPTAVTSPSAQNVAAGGATVAGAAATAAQVASALGATTGSVTPAIATATPATQPDMPVFTCPRRPNLGREGRPIVLRANHFQVTMPRGYVHHYDINIQPDKCPRKVNREIIETMVHAYSKIFGVLKPVFDGRNNLYTRDPLPIGNERLELEVTLPGEGKDRIFRVTIKWQAQVSLFNLEEALEGRTRQIPYDAILALDVVMRHLPSMTYTPVGRSFFSSPEGYYHPLGGGREVWFGFHQSVRPSQWKMMLNIDVSATAFYKAQPVIDFMCEVLDIRDINEQRKPLTDSQRVKFTKEIKGLKIEITHCGQMRRKYRVCNVTRRPAQMQSFPLQLENGQTVECTVAKYFLDKYRMKLRYPHLPCLQVGQEHKHTYLPLEVCNIVAGQRCIKKLTDMQTSTMIKATARSAPDREREINNLVKRADFNNDSYVQEFGLTISNSMMEVRGRVLPPPKLQYGGRVSTGLTGQQLFPPQNKVSLASPNQGVWDMRGKQFFTGVEIRIWAIACFAPQRTVREDALRNFTQQLQKISNDAGMPIIGQPCFCKYATGPDQVEPMFRYLKITFPGLQLVVVVLPGKTPVYAEVKRVGDTVLGMATQCVQAKNVNKTSPQTLSNLCLKINVKLGGINSILVPSIRPKVFNEPVIFLGADVTHPPAGDNKKPSIAAVVGSMDAHPSRYAATVRVQQHRQEIIQELSSMVRELLIMFYKSTGGYKPHRIILYRDGVSEGQFPHVLQHELTAIREACIKLEPEYRPGITFIVVQKRHHTRLFCAEKKEQSGKSGNIPAGTTVDVGITHPTEFDFYLCSHQGIQGTSRPSHYHVLWDDNHFDSDELQCLTYQLCHTYVRCTRSVSIPAPAYYAHLVAFRARYHLVEKEHDSGEGSHQSGCSEDRTPGAMARAITVHADTKKVMYFA"

     misc_feature    784..1173
                     /gene="AGO1"
                     /locus_tag="Dmel_CG6671"
                     /gene_synonym="Ago; ago-1; Ago-1; AGO-1; ago1; Ago1;
                     ago1-1; Agp1; anon-WO0257455.29; argonaute1; CG6671;
                     dAgo1; dAGO1; Dm Ago1; dmAgo1; DmAgo1; Dmel\CG6671;
                     l(2)04845; l(2)4845; l(2)k00208; l(2)k08121; MRE20"
                     /note="N-terminal domain of argonaute; Region: ArgoN;
                     pfam16486"
                     /db_xref="CDD:465134"
     misc_feature    1201..1353
                     /gene="AGO1"
                     /locus_tag="Dmel_CG6671"
                     /gene_synonym="Ago; ago-1; Ago-1; AGO-1; ago1; Ago1;
                     ago1-1; Agp1; anon-WO0257455.29; argonaute1; CG6671;
                     dAgo1; dAGO1; Dm Ago1; dmAgo1; DmAgo1; Dmel\CG6671;
                     l(2)04845; l(2)4845; l(2)k00208; l(2)k08121; MRE20"
                     /note="Argonaute linker 1 domain; Region: ArgoL1;
                     pfam08699"
                     /db_xref="CDD:462567"
     misc_feature    1354..1716
                     /gene="AGO1"
                     /locus_tag="Dmel_CG6671"
                     /gene_synonym="Ago; ago-1; Ago-1; AGO-1; ago1; Ago1;
                     ago1-1; Agp1; anon-WO0257455.29; argonaute1; CG6671;
                     dAgo1; dAGO1; Dm Ago1; dmAgo1; DmAgo1; Dmel\CG6671;
                     l(2)04845; l(2)4845; l(2)k00208; l(2)k08121; MRE20"
                     /note="PAZ domain, argonaute_like subfamily. Argonaute is
                     part of the RNA-induced silencing complex (RISC), and is
                     an endonuclease that plays a key role in the RNA
                     interference pathway. The PAZ domain has been named after
                     the proteins Piwi,Argonaut, and Zwille; Region:
                     PAZ_argonaute_like; cd02846"
                     /db_xref="CDD:239212"
     misc_feature    order(1510..1512,1555..1557,1597..1599,1609..1611,
                     1663..1665,1684..1686,1690..1692)
                     /gene="AGO1"
                     /locus_tag="Dmel_CG6671"
                     /gene_synonym="Ago; ago-1; Ago-1; AGO-1; ago1; Ago1;
                     ago1-1; Agp1; anon-WO0257455.29; argonaute1; CG6671;
                     dAgo1; dAGO1; Dm Ago1; dmAgo1; DmAgo1; Dmel\CG6671;
                     l(2)04845; l(2)4845; l(2)k00208; l(2)k08121; MRE20"
                     /note="nucleic acid-binding interface [nucleotide
                     binding]; other site"
                     /db_xref="CDD:239212"
     misc_feature    1852..3174
                     /gene="AGO1"
                     /locus_tag="Dmel_CG6671"
                     /gene_synonym="Ago; ago-1; Ago-1; AGO-1; ago1; Ago1;
                     ago1-1; Agp1; anon-WO0257455.29; argonaute1; CG6671;
                     dAgo1; dAGO1; Dm Ago1; dmAgo1; DmAgo1; Dmel\CG6671;
                     l(2)04845; l(2)4845; l(2)k00208; l(2)k08121; MRE20"
                     /note="PIWI domain, Argonaute-like subfamily. Argonaute is
                     the central component of the RNA-induced silencing complex
                     (RISC) and related complexes. The PIWI domain is the
                     C-terminal portion of Argonaute and consists of two
                     subdomains, one of which provides the...; Region:
                     Piwi_ago-like; cd04657"
                     /db_xref="CDD:240015"
     misc_feature    order(2305..2307,2317..2319,2353..2364,2371..2373,
                     2395..2397,2404..2406,2416..2418,2428..2430)
                     /gene="AGO1"
                     /locus_tag="Dmel_CG6671"
                     /gene_synonym="Ago; ago-1; Ago-1; AGO-1; ago1; Ago1;
                     ago1-1; Agp1; anon-WO0257455.29; argonaute1; CG6671;
                     dAgo1; dAGO1; Dm Ago1; dmAgo1; DmAgo1; Dmel\CG6671;
                     l(2)04845; l(2)4845; l(2)k00208; l(2)k08121; MRE20"
                     /note="5' RNA guide strand anchoring site [active]"
                     /db_xref="CDD:240015"
     misc_feature    order(2509..2511,2515..2517,2728..2730,3142..3144)
                     /gene="AGO1"
                     /locus_tag="Dmel_CG6671"
                     /gene_synonym="Ago; ago-1; Ago-1; AGO-1; ago1; Ago1;
                     ago1-1; Agp1; anon-WO0257455.29; argonaute1; CG6671;
                     dAgo1; dAGO1; Dm Ago1; dmAgo1; DmAgo1; Dmel\CG6671;
                     l(2)04845; l(2)4845; l(2)k00208; l(2)k08121; MRE20"
                     /note="active site"
                     /db_xref="CDD:240015"
ORIGIN      

caaataagttgtgtttgtgcaaaactcgcgcgttcgcaattttccgaagctgactctcaattctcatacataacgatctcaagcgatctccgccaggcgaatcaaacccggatatatccagatctgcacgctggaaaagtaacgtccgcaacggtttaaatccagtcgagacgcaaaccccactcaactccttaatgagttcccctccattaaacggaattcaccaaaaaaaacgattgatttgccgctgataaagctgataaaagcgcacacacacaccaaagtcagctgcaattttgcgataaggagcagcgacgccgcctcaaactgacgccgacaccgactaaaatgtccacggagcgtgagctggctcccggtgggccagctcagctccatccgcacacgctgccgctgacttttccggatctccagatgacctccaccgtgggcatcattgggaaagtctacgagtcacagtggaccccctcgcccactcggcctcagagtccctctcaggcgcagactagcttcgacacgctcacatcaccaccagcgcccggctcgtcggtcaatcccaccgccgtcaccagcccaagtgcccagaatgtggccgctggtggagcaactgtggccggtgcagcagcaactgccgcccaggtggcctccgccttgggtgccaccaccggcagcgtgacgccagcaattgccaccgcaacgccagccacgcagccggatatgcccgtctttacgtgtccacgacgcccgaatctcggacgagagggtcgcccgattgtgctgcgcgccaatcacttccaggtgacaatgccgcgtggctatgtgcatcactatgacatcaatatacagccggacaagtgtccgcgaaaggtgaaccgtgagattatcgagactatggtgcatgcctatagcaagatcttcggagtgctcaagccggtgttcgatggtcgcaacaatctgtatacccgcgatcccctgcccattggcaacgagcgtctagagctggaggttactctacccggcgagggcaaagatcgaatctttcgcgtgacgatcaagtggcaggctcaggtctcgctcttcaatttggaggaagctctcgaaggccgcacgcggcagataccctatgatgccattttggcgctcgatgtggtcatgcgccatctgcccagcatgacgtacacgccagtgggacgtagcttcttcagttccccggagggttactaccatcccctgggtggtggacgcgaggtttggttcggtttccatcagagcgtaaggccctcgcagtggaagatgatgctcaatatcgatgtctcggccaccgctttctacaaggctcaaccagtcattgacttcatgtgcgaggtgctggacattcgcgacatcaacgagcagcgcaaaccgctcaccgattcgcagcgcgtcaagttcacgaaggagatcaagggtttgaagatcgagatcacccactgcggccagatgcgtcgcaagtatcgtgtgtgcaacgtcactcgccgccccgctcagatgcaatcattcccactgcagctggagaacggacagaccgtagagtgcaccgtggccaagtacttcctggacaagtaccgcatgaaattgcgctacccgcacttgccctgcctgcaggttggccaagagcacaagcacacttacctgcctctagaggtgtgcaacattgtggccggacagcggtgcattaaaaagctgaccgatatgcagacgtcgaccatgatcaaggccacagctcgttcagctccggatcgtgagcgtgagattaacaacttggtaaagcgcgccgacttcaacaacgattcgtatgtgcaagagtttggcctgaccatctccaattcgatgatggaggtacgaggacgcgtcttgcctcctcccaagcttcagtatgggggacgtgtgtctaccggcctcaccggccagcagctgttcccgccacagaacaaggtgagcttggcctcgcccaaccagggtgtatgggatatgcgaggcaagcagttcttcactggcgtcgagatccgcatctgggccatcgcctgttttgccccacagcgcacggtgcgcgaggatgcgctgcgtaatttcacccagcagctgcagaagatctcaaacgatgcaggcatgccgataattggacagccgtgcttctgtaagtacgccaccgggccggatcaagtggaacccatgttccgttacctgaagatcaccttccccggcctgcaactcgtcgtggttgtgctgcccggcaagactccagtatacgccgaggtgaagcgtgtaggtgacaccgttctgggtatggccacccagtgtgtgcaggccaagaacgtgaacaagacatcgccacagacgctctctaatctgtgtctgaagatcaacgtcaagttgggcggcatcaattcaattctggtcccctccattcggccaaaggtcttcaatgagccggtcatctttttgggtgccgatgtgacacacccaccagctggcgacaacaagaaaccatcgattgccgccgtcgtgggctccatggatgcccatccatcgcggtatgccgccaccgttcgcgtacagcagcaccgacaggagatcatccaggagctgagcagcatggtgcgcgagctgttgatcatgttctacaagtcgacgggcggctacaagccccaccgcatcatactctatcgtgacggagtctccgagggacaattcccacatgtcctgcaacacgaattgaccgccattcgcgaggcctgcattaagctagagccagagtatcggccgggcatcacattcattgtggtgcagaagcgccatcacactcgactcttctgcgcggagaagaaggagcagagcggcaaatcgggcaatattcccgcaggcaccaccgtcgatgtgggcatcacacatcccaccgaatttgatttctatctatgcagccatcagggcatccagggcaccagtcgcccctcgcactaccacgttctgtgggacgacaatcactttgactcggacgagctgcagtgcctcacgtatcagctatgccatacgtacgtgcgctgcacccgatccgtcagtataccggcgccagcctactacgcccatttagtggccttccgtgccagatatcatctggtggagaaggagcacgattcgggcgagggttcgcaccagagcggctgctcagaggatcgtacgccaggtgccatggccagggccatcactgtgcacgcggataccaagaaggtcatgtactttgcctaaaaagtatcgcccctccccaataccaacaccaaaaagctaaagaatacaaaatcagtttcgaatttcgattcgaataagcaactccccacttccttccctcaaatcagaaagcggaaagcggatgaaagccaagcatagaagtttagaattaagttacgttttacgttgagagagcgcggatgggtggaaaaaccaatcagaatacgaagatcttgcatgcattagttacgtacacgtacatatatagtaagcagagtaatgaaaatcccacaaacaccatccacacactcactcatccacacacacacaaatcagatagccacacagtgagaaatgataactaatcgaatgtcaggcacaagtttgcgaaatcaaagaaatgtgagaattctcaaaaacaagcgtagcaaacaaattgaaagcaaataggaaatcaactaaagggaacaaaaactacgacagcaacaccaaccaacaccagaaaaacaaaacaaattaaaacataaccaaaatggaagtgaaattacgtgaaaagcgagcgtcatcagcacgagagagagagacaagttttgtaatagaaattacgattaaattgtacaatatatttttacacgatacgaaatgaagacatgatgaatgataatgaatgaatgcatacaaccaaaggtttttagtatacaaaatgaatacgttgctgatcgactcacacagcaaacaccacatgaacaccaaccactcggattctctgtactgtgaacgaagaccaccaccaaaatataaacaaaaaccacaagcgacattaaagcgacaagcattgaaagagtgtgtagacacaacttagcatgtactaatgaattacttcaatacttcaactagggcgctgacaaaaccaagcaagaacatttaatagtttgtaagttgggctctaccaaaaaccgaacacaaaatgagagagagagagagagagaaaaatgcaagcaaggccagataagttaagtgggcaatgaataacgagaactgcaatttcaacaagggacaaacttttggtcaaaacaatagctatacttatagagcagagcctaatatatacatacataattagaatctaaaactaaaatttaaagtttttacgaaacgataaccaagcggatggagctgttgtaacaatgtagattacttaaattcaaaagtgcaaataacacggtagcagacacgttacgttggcagtgctgatattttatgttagtccttagtttaccctcttttatgcaccacaccaccacacaatcagactccgaacttcttcaaccctcctcgagtccaaggcatatcactcaatgtcctcttatttatgtacctcctacaataagccttatgatatatttagttgtaccttatatatatatatatatattttttaaaacgaatgcctaacgaaatttgttgatttcttcatgttgatgcttcgaattggcttcttcgctgcttttcgttgtaataatttcgtattaattaactttagatcaaagtggtgtacgggtaataataaacaaggtaactcttctccaccgtccgccggagggaggtggcaacaacatttcaatattttacaaagtagttttagtttcgccaaaatcaacaagcaaacaaacaatatcaatatcaatatgaaacgtatgcttagtaattgtactatatcgaggacacagttcaagttaacattataatgagttgttatttatgcggcgcgggcgacgacgttctatccactcggaatcgcccgggccaaacctaatttataattgtatacatccttcttcacagaacctttaatttagatttagtttccaagtttgcaagctgttttgccaatcgtacattatgtgagcattataaaatacataatatatataaatctatatgcttatatttaatcatttactgcacttacaaattagttggtaatcctcaagaatatatgtataaagaaaaaaagggaacagaacggaagaaaggaggtcgcacgcggtccctcaaaatgttgaatcgaacttatagaaatctctttggatttgaaatcatatacaaactggtggaacttcacgaatgatttcaaatcccttgatatttcagtggtggcaaaaaatttttaaatctgcattctcaatgcctgtttttaaacttctcgatgtttatcatttagtcaactacttcgagtgcaatgatatcttttgcagaaattttaaaaccagagttaatatttaaaagtcttcaaataaagttttttttttgtctaaattttgactagtccttccaacgaggctcaacatagctgatattaatagcttattaattaattaatattaattggtaatgcgtttaaatgcgattaacattttgtggggctgtgcaattaattgtgtgggcgtatttgtggacttattcattttccatttttttttctaataacgtttctacacaagggattaaaattttaaacttatgtcttaatttttacttaaagcaacccgatgcaaaaaaaaacaaacaaacaaaaaccaacaaaaaaacgaatcaaacaattttagttttaagaaaaaaaaaaacaagaaaacgaaaacgaaacaatgcaaaggagttcgcgattcggggctcgatttttgagatcggccagaaagaaccaacatttacattatatattcacttagtttaagctgaagctgaaatgtgtgccgacaatgaatgcatctcgtagttgtaaaatgagcgaaatattcaacaataatttactttaccacacaatacatgagaaagtccaaagctttaacttactcgcaagatgaatgaagcggaaatatcggtgggaaaacccttatcactaatgaaaatgccaataacaagctgctatctcctcccatccaagaaaaatgggctgtaacagttgtccctatatacacgcgtaaaacttatacatatatagtaaagctggataactccgattttcccaagaactcaagaaaactactcacacacgctacaatttcaatggtttcttcagtgtcgtgcagctaagtaaaaggaaaacaagttggaggagaagattgaagatcgtggatggccttagatatcatttccaaactatgttctgctcagaggcaaggcccaaataaaaagacaaaaagccgggatatccaaatgggaacttacatttttatctgtcaaaattcaattgagctttaaactaaagatagatcgagaaaaaacgaaaataaaaaaaaaacaaaaaaaaaatggaagtaaaaacttgaacaaaaaaaagaagagaagagtaagaaatacagaaaggaatcgcattgtttctacatattacttataaatgtgccgtttatagatgtctacaattatatacaacaaatatagatatatacctagatatataatcagatcgaaatcgaagctagaacagcaatttgcacaactcttcctaaaggaaataaaaagataaaaatacaaatctaaatctaactaacgattaaattacatatatgccacaattaccgagatttcaagaagtgacggactaactccaagcaattaaaacgttatatttgaaataacttatgaacttatgataccatatatgtatgtgtgtactctatactcttccaactagacccagagtcccactcgaacccggaccacatgcgcgatccacatagccattagcccacaaacactcaatccacacaatacacacaatccacactcgacttagtgttccaaatgcgcatcggatcagatcggataacgaaccccttagctgaaattcgactagcaaaatcaatacgttagtaacacttattcgtgcgttaagattagggagatcatctggtacataccttactttaaaaatcaaccaaaatgccgggtaattaatcaataaaatacatattattagttctaatctaagaggagtaaacaaaaacaaaacaaaaacaaaaggaaaacaaaaatacatcaacattatgaataaagaaaaataagcaacgtgagcaacgtaatatgggaaatctgtaactttggtgatctttttaaatgttattagtaaaagaaggcaaaacaaaatcaagtttaatgacgaatacaaatcaaaccagttttaaatgtgacttaaattacgacgtaaacgacatttttccacaacattatatgtgtaaacaagacgaaaaacaaaacaaaaaatgcaaaatgcgagtttgtgaaatatgcaatttaatgaaagttgatgatcttttcgatataattctgtcaagctgtcttaacaattagttataagcgcttcaatacaagaaaccatcaaacaaaaatcaacaaactcaattaagttatggaaaacacaattatatataacaacaaatcgtatatgttttatacaaattgtaattatttttatcgatttcgatttgattttttaaacccacgaaatgtacccatcccttgtaaaacaaaaacgattttagtttgcgtttaaaataagaaaacagcatatacaattcatttttgttcaataaaaatatatttaact

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