LOCUS       NM_001171927            1920 bp    mRNA    linear   VRT 07-FEB-2024
DEFINITION  Xenopus tropicalis iroquois homeobox 5 (irx5), mRNA.
ACCESSION   NM_001171927
VERSION     NM_001171927.1
KEYWORDS    RefSeq.
SOURCE      Xenopus tropicalis (tropical clawed frog)
  ORGANISM  Xenopus tropicalis
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae;
            Xenopus; Silurana.
REFERENCE   1  (bases 1 to 1920)
  AUTHORS   Rodriguez-Seguel,E., Alarcon,P. and Gomez-Skarmeta,J.L.
  TITLE     The Xenopus Irx genes are essential for neural patterning and
            define the border between prethalamus and thalamus through mutual
            antagonism with the anterior repressors Fezf and Arx
  JOURNAL   Dev Biol 329 (2), 258-268 (2009)
   PUBMED   19268445
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CU025206.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CU025206.1, CF150935.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00028291, SAMD00028292
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1920
                     /organism="Xenopus tropicalis"
                     /mol_type="mRNA"
                     /db_xref="taxon:8364"
                     /chromosome="4"
                     /map="4"
     gene            1..1920
                     /gene="irx5"
                     /gene_synonym="iroquois-5; irx-2a; Xiro5"
                     /note="iroquois homeobox 5"
                     /db_xref="GeneID:100038201"
                     /db_xref="Xenbase:XB-GENE-484376"
     exon            1..420
                     /gene="irx5"
                     /gene_synonym="iroquois-5; irx-2a; Xiro5"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    157..159
                     /gene="irx5"
                     /gene_synonym="iroquois-5; irx-2a; Xiro5"
                     /note="upstream in-frame stop codon"
     CDS             172..1632
                     /gene="irx5"
                     /gene_synonym="iroquois-5; irx-2a; Xiro5"
                     /codon_start=1
                     /product="iroquois-class homeodomain protein irx-5"
                     /protein_id="NP_001165398.1"
                     /db_xref="GeneID:100038201"
                     /db_xref="Xenbase:XB-GENE-484376"
                     /translation="

MCLAMSYPQGYLYQPSASLALYSCPAYSTTVISGPRTDELGRSPSGSAFSPYAGSTAFTASSAGFNSPLQYSGDPAAAFTSYVGSPYDHSAGMAGSLGYHPYAAPLGTYPYGDPAYRKNATRDATATLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMTWTPRNRSEDEEDDENIDLEKNEEDDPRKLEEKGDQDGDAGDQKRSPSAVDFDRLEGEVRQGKELDQTRSDSEQNEVEERNDLLSKNSAPPTSPLCPPDQSPQAQEDQNLHRHTVHNHHHQSIQQLHHHSHQSHPLDLVHRNALVQHGPVTNNATSVIHSPPASTSKPKLWSLAEIATSSDKVKESSDAAAVAGTTPAQSMVVSASSPSRSPSAQCHFPSNTVLSRPLYYSNPFYPGYTNYGTFSHLHSHHGPSTTSPTVNSTHHFSGINQTVLNRAEALAKECKLRSQSQADLNKDTPYEMKKGMSSI"

     misc_feature    order(520..525,529..531,589..591,607..609,646..648,
                     652..657,664..669,673..681,685..690)
                     /gene="irx5"
                     /gene_synonym="iroquois-5; irx-2a; Xiro5"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238039"
     misc_feature    order(526..528,655..657,664..669,676..678)
                     /gene="irx5"
                     /gene_synonym="iroquois-5; irx-2a; Xiro5"
                     /note="specific DNA base contacts [nucleotide binding];
                     other site"
                     /db_xref="CDD:238039"
     misc_feature    565..681
                     /gene="irx5"
                     /gene_synonym="iroquois-5; irx-2a; Xiro5"
                     /note="Homeobox KN domain; Region: Homeobox_KN; pfam05920"
                     /db_xref="CDD:428673"
     misc_feature    1189..1242
                     /gene="irx5"
                     /gene_synonym="iroquois-5; irx-2a; Xiro5"
                     /note="Motif in Iroquois-class homeodomain proteins
                     (only). Unknown function; Region: IRO; smart00548"
                     /db_xref="CDD:214716"
     exon            421..823
                     /gene="irx5"
                     /gene_synonym="iroquois-5; irx-2a; Xiro5"
                     /inference="alignment:Splign:2.1.0"
     exon            824..1888
                     /gene="irx5"
                     /gene_synonym="iroquois-5; irx-2a; Xiro5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

ggaacagagaaaaagagagcagcagcaggaggcagcaagaactgggactgcttttctgtactgcaactggtggggttcatttctatgcatttgtgtccggaaaccctgacaagagctgggtcccagttttccttgtactgtgtgcgtctcaaccgataagagtttatatgcatgtgtcttgccatgtcctatcctcagggctacttataccaaccatctgcttctttggctctgtactcctgccctgcttacagcaccactgtcatctctggacccaggactgatgagcttgggaggtccccttctggctctgccttctcaccttacgctggatctacagctttcactgccagctctgctggcttcaactctcccctccagtacagcggggacccagctgctgcctttacttcctatgtgggctctccgtatgatcacagcgctggcatggctggatcattaggatatcacccatatgctgctcctttgggaacgtatccttatggcgacccagcgtacaggaaaaatgccaccagagatgcaactgccactttgaaggcctggctcaacgaacacaggaagaatccttaccccacaaagggcgagaagattatgttggctattattactaagatgaccctaactcaagtgtccacctggtttgctaacgcaaggaggaggctaaaaaaagaaaataaaatgacatggactccgagaaacaggagtgaggatgaggaggatgacgaaaatattgatctggaaaaaaatgaagaagacgatccaagaaaacttgaagagaagggggaccaagatggagatgcaggggatcaaaagaggagccctagtgcggtggattttgacaggttagaaggtgaagtacgtcagggtaaggagctggaccagacaaggagcgattctgaacagaacgaagtagaggaaagaaatgatcttctgtccaaaaactctgctccccccacctcacccctgtgccctccagatcagtccccgcaggcccaagaagatcagaacttgcatcgtcacactgttcacaaccaccaccaccagtcaatccagcaactacatcaccacagtcaccagtctcatccattagacctggtgcataggaacgctcttgtccaacatggcccagtcaccaacaatgccacctcagttatccactccccaccagcttccacctcaaagcctaaactctggtcactggcagagatagcaacttcttcggacaaagtcaaagaaagcagcgatgctgctgcagttgcagggaccactccagcccagtctatggttgttagtgcctcttctccatccagatcaccttcggcacaatgccatttccccagcaacaccgttctgtctcgtcccctttattacagcaatcccttttaccctggttatacgaactatggcactttcagtcaccttcacagccaccatggacctagcacaactagcccaacggttaacagcacccatcatttcagtggaataaaccagactgtattaaacagagccgaggctttggccaaagagtgcaaacttagaagccagtcacaagctgacctaaacaaagacacgccttatgaaatgaagaaaggtatgtctagcatttaattttggcttcctctacaggccttggacttccattttttaatttattgaacatacaatgccttgttagtgtattccttcaccatcaagaaaataattattaacggttgaaatccaaagtatttttggtactttgatttaacagatgtcttaatccaactgcaagaaaatacctgatttgtattaatcggattctgtatatttacgtagcgaatttgtatttaaatggatcatcaatatcagtaaattatgaaaacaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa

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