LOCUS       NM_001166041            1011 bp    mRNA    linear   VRT 02-APR-2025
DEFINITION  Xenopus tropicalis ISL LIM homeobox 2 (isl2), mRNA.
ACCESSION   NM_001166041
VERSION     NM_001166041.1
KEYWORDS    RefSeq.
SOURCE      Xenopus tropicalis (tropical clawed frog)
  ORGANISM  Xenopus tropicalis
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae;
            Xenopus; Silurana.
REFERENCE   1  (bases 1 to 1011)
  AUTHORS   Shi,Y., Zhao,S., Li,J. and Mao,B.
  TITLE     Islet-1 is required for ventral neuron survival in Xenopus
  JOURNAL   Biochem Biophys Res Commun 388 (3), 506-510 (2009)
   PUBMED   19666005
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from GQ423190.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: GQ423190.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00028293, SAMD00028294
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1011
                     /organism="Xenopus tropicalis"
                     /mol_type="mRNA"
                     /db_xref="taxon:8364"
                     /chromosome="3"
                     /map="3"
     gene            1..1011
                     /gene="isl2"
                     /gene_synonym="islet-2; islet2b"
                     /note="ISL LIM homeobox 2"
                     /db_xref="GeneID:100306962"
                     /db_xref="Xenbase:XB-GENE-487556"
     exon            1..67
                     /gene="isl2"
                     /gene_synonym="islet-2; islet2b"
                     /inference="alignment:Splign:2.1.0"
     CDS             10..1011
                     /gene="isl2"
                     /gene_synonym="islet-2; islet2b"
                     /note="islet 2"
                     /codon_start=1
                     /product="insulin gene enhancer protein ISL-2"
                     /protein_id="NP_001159513.1"
                     /db_xref="GeneID:100306962"
                     /db_xref="Xenbase:XB-GENE-487556"
                     /translation="

MVDPILPCPLSAAMGEHPKKKAGLAVCVGCGSHILDQYILRVSPDLEWHAACLKCAECSQYLDENCTCFVRDGKTYCKRDYIRLFSARCPRCQGTLPRSELVMRVGERVYHTDCFRCSVCSRRLLPGEEISLRDQDLLCGAEHNLSDSGRPSSLRSHIHKQTEKTTRVRTVLNEKQLHTLRTCYAANPRPDALMKEQLVEMTGLSPRVIRVWFQNKRCKDKKKSILMKQLQQQQLNDKTSLQGLTGTPMVAGSPIRHDSAVQGSAVEVQTYQPPWKALSDFALQSDLDQPAFQQLVSFSESGSLGNSSGSDIASLSSQLPDTPNSMVPSPVET"

     misc_feature    88..252
                     /gene="isl2"
                     /gene_synonym="islet-2; islet2b"
                     /note="The first LIM domain of Isl, a member of LHX
                     protein family; Region: LIM1_Isl; cd09366"
                     /db_xref="CDD:188752"
     misc_feature    order(88..90,97..99,154..156,163..165,172..174,181..183,
                     238..240,247..249)
                     /gene="isl2"
                     /gene_synonym="islet-2; islet2b"
                     /note="Zn binding site [ion binding]; other site"
                     /db_xref="CDD:188752"
     misc_feature    274..438
                     /gene="isl2"
                     /gene_synonym="islet-2; islet2b"
                     /note="The second LIM domain of Isl, a member of LHX
                     protein family; Region: LIM2_Isl; cd09374"
                     /db_xref="CDD:188760"
     misc_feature    order(274..276,283..285,340..342,349..351,358..360,
                     367..369,424..426,433..435)
                     /gene="isl2"
                     /gene_synonym="islet-2; islet2b"
                     /note="Zn binding site [ion binding]; other site"
                     /db_xref="CDD:188760"
     misc_feature    502..672
                     /gene="isl2"
                     /gene_synonym="islet-2; islet2b"
                     /note="Homeodomain; Region: HOX; smart00389"
                     /db_xref="CDD:197696"
     misc_feature    order(508..519,523..525,574..576,592..594,631..633,
                     637..642,649..654,658..666,670..675)
                     /gene="isl2"
                     /gene_synonym="islet-2; islet2b"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238039"
     misc_feature    order(511..513,520..522,640..642,649..654,661..663)
                     /gene="isl2"
                     /gene_synonym="islet-2; islet2b"
                     /note="specific DNA base contacts [nucleotide binding];
                     other site"
                     /db_xref="CDD:238039"
     exon            68..257
                     /gene="isl2"
                     /gene_synonym="islet-2; islet2b"
                     /inference="alignment:Splign:2.1.0"
     exon            258..448
                     /gene="isl2"
                     /gene_synonym="islet-2; islet2b"
                     /inference="alignment:Splign:2.1.0"
     exon            449..726
                     /gene="isl2"
                     /gene_synonym="islet-2; islet2b"
                     /inference="alignment:Splign:2.1.0"
     exon            727..894
                     /gene="isl2"
                     /gene_synonym="islet-2; islet2b"
                     /inference="alignment:Splign:2.1.0"
     exon            895..1011
                     /gene="isl2"
                     /gene_synonym="islet-2; islet2b"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

cagctgtatatggtggatcctatcttgccctgcccgctctcggctgctatgggagagcatcccaaaaagaaggccggcctggccgtgtgtgtgggctgtgggagccacatcctcgatcagtacatcctgagagtgtccccagacctggagtggcacgcagcttgcctcaagtgcgccgagtgcagtcagtacctggatgaaaattgcacttgttttgtgcgggacggcaagacttactgcaagagggactatatcaggttattcagtgccaggtgcccccgctgccaagggactctgccccgctctgagctggtgatgagagtgggggagagggtgtatcacacagactgcttccgatgttctgtctgcagccgccgactccttccaggggaagagatcagcctgagggaccaagatctgttgtgtggggcagagcacaacctgtcagactctggcaggccctcatccctcaggtctcacatccacaaacaaacagaaaagactaccagggttcggacggtactaaatgaaaagcaactacatacattacgtacatgctatgcagccaatccccgtccagatgccctgatgaaggaacagctggttgaaatgactggactcagtccgcgggttatccgagtatggtttcagaacaagcgatgtaaagacaagaagaaatccattctcatgaaacagctccagcagcagcaactgaatgacaaaacaagcctgcagggtttgacaggaacaccaatggtagcaggaagtccaatccggcatgacagtgctgtgcagggaagtgccgttgaggtacagacatatcagccaccatggaaagcactcagtgactttgcattacagagtgacctggatcagcctgcattccaacaactggtgtctttttcggagtctggttccctaggaaactcttctggcagtgacatcgcttctctgtcctctcagcttcccgacaccccgaacagcatggtgcccagccctgtggagacgtga

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