LOCUS       NM_001142077            3147 bp    mRNA    linear   VRT 05-FEB-2024
DEFINITION  Xenopus tropicalis pre-B-cell leukemia homeobox 1 (pbx1), mRNA.
ACCESSION   NM_001142077
VERSION     NM_001142077.1
KEYWORDS    RefSeq.
SOURCE      Xenopus tropicalis (tropical clawed frog)
  ORGANISM  Xenopus tropicalis
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae;
            Xenopus; Silurana.
REFERENCE   1  (bases 1 to 3147)
  AUTHORS   Klein,S.L., Strausberg,R.L., Wagner,L., Pontius,J., Clifton,S.W.
            and Richardson,P.
  TITLE     Genetic and genomic tools for Xenopus research: The NIH Xenopus
            initiative
  JOURNAL   Dev Dyn 225 (4), 384-391 (2002)
   PUBMED   12454917
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC168027.1.
            
            ##Evidence-Data-START##
            CDS exon combination :: BC168027.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMN00861988, SAMN00861997 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..3147
                     /organism="Xenopus tropicalis"
                     /mol_type="mRNA"
                     /db_xref="taxon:8364"
                     /chromosome="4"
                     /map="4"
     gene            1..3147
                     /gene="pbx1"
                     /gene_synonym="pbx1b; Xpbx1; Xpbx1b"
                     /note="pre-B-cell leukemia homeobox 1"
                     /db_xref="GeneID:100216094"
                     /db_xref="Xenbase:XB-GENE-1217592"
     exon            1..454
                     /gene="pbx1"
                     /gene_synonym="pbx1b; Xpbx1; Xpbx1b"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    198..200
                     /gene="pbx1"
                     /gene_synonym="pbx1b; Xpbx1; Xpbx1b"
                     /note="upstream in-frame stop codon"
     CDS             264..1307
                     /gene="pbx1"
                     /gene_synonym="pbx1b; Xpbx1; Xpbx1b"
                     /codon_start=1
                     /product="pre-B-cell leukemia transcription factor 1"
                     /protein_id="NP_001135549.1"
                     /db_xref="GeneID:100216094"
                     /db_xref="Xenbase:XB-GENE-1217592"
                     /translation="

MDDQPRLMHSHPGVGMAGHPSLSQHMQDGTGANEGEGGRKQDIGDILQQIMTITDQSLDEAQARKHALNCHRMKPALFNVLCEIKEKTVLSIRGAQEEEPADPQLMRLDNMLLAEGVAGPEKGGGSAAAAAAAAASGGAGADNSAEHSDYRAKLSQIRQIYHTELEKYEQACNEFTTHVMNLLREQSRTRPISPKEIERMVSIIHRKFSSIQMQLKQSTCEAVMILRSRFLDARRKRRNFNKQATEILNEYFYSHLSNPYPSEEAKEELAKKCAITVSQVSNWFGNKRIRYKKNIGKFQEEANIYAAKTAVNATNVSVHGSQANSPSTPSSAGGYPSPCYQSDRRIQ"

     misc_feature    264..383
                     /gene="pbx1"
                     /gene_synonym="pbx1b; Xpbx1; Xpbx1b"
                     /note="propagated from UniProtKB/Swiss-Prot (B4F6V6.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    387..959
                     /gene="pbx1"
                     /gene_synonym="pbx1b; Xpbx1; Xpbx1b"
                     /note="PBC domain; Region: PBC; pfam03792"
                     /db_xref="CDD:461052"
     misc_feature    396..635
                     /gene="pbx1"
                     /gene_synonym="pbx1b; Xpbx1; Xpbx1b"
                     /note="propagated from UniProtKB/Swiss-Prot (B4F6V6.1);
                     Region: PBC-A.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU01322"
     misc_feature    642..959
                     /gene="pbx1"
                     /gene_synonym="pbx1b; Xpbx1; Xpbx1b"
                     /note="propagated from UniProtKB/Swiss-Prot (B4F6V6.1);
                     Region: PBC-B.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU01322"
     misc_feature    963..1145
                     /gene="pbx1"
                     /gene_synonym="pbx1b; Xpbx1; Xpbx1b"
                     /note="Homeodomain; DNA binding domains involved in the
                     transcriptional regulation of key eukaryotic developmental
                     processes; may bind to DNA as monomers or as homo- and/or
                     heterodimers, in a sequence-specific manner; Region:
                     homeodomain; cd00086"
                     /db_xref="CDD:238039"
     misc_feature    order(963..977,981..983,1041..1043,1059..1061,1098..1100,
                     1104..1109,1116..1121,1125..1133,1137..1142)
                     /gene="pbx1"
                     /gene_synonym="pbx1b; Xpbx1; Xpbx1b"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238039"
     misc_feature    order(969..971,978..980,1107..1109,1116..1121,1128..1130)
                     /gene="pbx1"
                     /gene_synonym="pbx1b; Xpbx1; Xpbx1b"
                     /note="specific DNA base contacts [nucleotide binding];
                     other site"
                     /db_xref="CDD:238039"
     misc_feature    1215..1304
                     /gene="pbx1"
                     /gene_synonym="pbx1b; Xpbx1; Xpbx1b"
                     /note="propagated from UniProtKB/Swiss-Prot (B4F6V6.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     exon            455..528
                     /gene="pbx1"
                     /gene_synonym="pbx1b; Xpbx1; Xpbx1b"
                     /inference="alignment:Splign:2.1.0"
     exon            529..773
                     /gene="pbx1"
                     /gene_synonym="pbx1b; Xpbx1; Xpbx1b"
                     /inference="alignment:Splign:2.1.0"
     exon            774..964
                     /gene="pbx1"
                     /gene_synonym="pbx1b; Xpbx1; Xpbx1b"
                     /inference="alignment:Splign:2.1.0"
     exon            965..1100
                     /gene="pbx1"
                     /gene_synonym="pbx1b; Xpbx1; Xpbx1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1101..1260
                     /gene="pbx1"
                     /gene_synonym="pbx1b; Xpbx1; Xpbx1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1261..1350
                     /gene="pbx1"
                     /gene_synonym="pbx1b; Xpbx1; Xpbx1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1351..3091
                     /gene="pbx1"
                     /gene_synonym="pbx1b; Xpbx1; Xpbx1b"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

gaggaaagcagagtctgagcccaaacaaaagcaggacaccgagctgtgtagaacttccctggcccggtacagaccccaccctcccgcggaaccgccgtgcctggatactgtaccttttcttcttgactaggacggattcctggcgccctgggattaacaggagggagccacaacaaaggcaggagagagaagaacaataagagttccctgtgcgctgcacaacacaggcacagggtgctgcagagcggggcttgctcctggaaatggatgatcagcccaggttgatgcacagccaccccggggtggggatggcgggacaccccagtctgtcccaacacatgcaggatggcacaggagccaacgaaggggaggggggcaggaagcaggacattggggatatattacagcagatcatgaccatcactgaccagagtctggatgaggcacaggccagaaaacacgctttgaactgccacagaatgaagcctgcgctattcaatgtattatgtgaaattaaggagaaaacagttctgagtattcggggagcacaagaagaggagcctgcagacccccagctaatgcggctagataacatgctgctggcagagggcgttgcaggcccagaaaagggaggagggtcagcggcagcagcagccgcagccgcagcatcaggtggagctggagctgacaactcagctgaacattctgactacagagcaaaactatcccaaataagacagatctatcacacagagctggagaaatatgaacaggcttgtaatgagttcaccactcacgtaatgaatcttctcagagaacagagcagaacccgacccatttccccgaaagagattgaacgtatggtgtcaattatccacaggaaatttagctcaatacaaatgcagctgaaacagagcacgtgtgaagctgtcatgatcctgcgctcacgcttcctggatgcacggcgaaaaagaagaaatttcaacaagcaagccacagaaattttgaatgagtatttctattcccacctcagcaacccataccctagcgaggaggccaaagaggaactagccaagaagtgtgccattacagtgtcacaggtatcaaactggttcggaaataagcgaatccgctataagaagaacataggtaaatttcaagaggaagccaatatttatgctgccaaaacggccgtgaatgctaccaatgtgtcagttcacggaagtcaagccaattcgccctcaactcccagttctgctggtggatacccttcgccatgttatcagtcagacaggcggatacagtgagactctgacagcgaatcagatgtacagtccgcagggcatcagtgctaatggggggtggcaggatgcagctaccccttcttctgtgacttccccaacagaaggacctggcagtgtccactctgatacctctaactgagttgcaggctcctacatcatcatcatcattctcaaaagccagattccatcccttccctctcactccagatggccactgtgggaatgcagaaaacagcagcctcatctgacatgcccatcagcactcccttcactgtcaatcatgatcttcttctttctccatgccttgctcagtttgcgttaatgaatgattcagaagtactgacaccatataaggacgtttgaattatgtgaaaagaaactaaaacaagaggaaattggatgtgggtagggagcaggatccatgtggtgatttaaaattggctgcacatttgcacgaaatcagccatctttaaataagctgcagaactttatttgcatacaaagaaatcacatactgtatgtccatccttggaaaagtatttttttacttcagtctggcatactgatactccacaaaccacctgagcctacacaggagcaccctattagattaaagcatttcatgaagaacctgccttctacttatttttgaaaaacttccctttttggatctgttcatatatctcagttcattaatagatggagccttgaactctgcaccatgtatgtcctggggtcactcttgaatgtttaacctcttcacctcttacagtcttacctactgcaccactcatgtaataacagtgaagttatgaggaataaggcctagattttgctacatagataggatgcaccgaacaccacttggaggtaatctgctggcagtaactacgtgcgtgatgggggtgaagaggttgcctactttagaggtttcctgctttaatactattggcagctggtccagttgtggataaagatgctactgagctccctgctaagacatcaatcaagcagacctcattacatctcttcagctgcactctgcctcccaggtcctagtctctgttccacagtatccttcaacatacaaggtttaatgcagattttttatttctattttgaattgacttcataaatattgcccccttttctggacattgcttttttccccatcacatttctaattactaaaatgaggccaaagccccatttcttctattagaaatcaatccatgccttttttatgatgctttccatatatccttatccagaaattactaggccactcacccagccctgaaacttttgcctgttgtataattattatgctgtacctaaacatagttcttaatacacaatttccttccctctgtttcatttttgaaacatcactctgcacagaaccgaggtacattctgctgtgacattgatgcctataaatggccttttcctttattttaccactcctgccaaggaactgaccccatggacatcactctgtgccaccctccttaatattcttcacttgttcatcattattttgaccttggtaaatcgtcctggctggcagctttcaaaggcacccacaaggtgtgtcagaaatccatgtttgataccaaaaatctgcacatactcgcacagaggaaaaacggacacagagggaagtgttcagctttattaacattcacataacttgtgtatcattgattgttatatttgggataaacatttgatgctggatgttcttgtatattctgaagaaaaaaaaaagaattgacaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa

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