LOCUS       NM_001128661            4223 bp    mRNA    linear   VRT 05-FEB-2024
DEFINITION  Xenopus tropicalis pre-B-cell leukemia homeobox 2 (pbx2), mRNA.
ACCESSION   NM_001128661
VERSION     NM_001128661.1
KEYWORDS    RefSeq.
SOURCE      Xenopus tropicalis (tropical clawed frog)
  ORGANISM  Xenopus tropicalis
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae;
            Xenopus; Silurana.
REFERENCE   1  (bases 1 to 4223)
  AUTHORS   Klein,S.L., Strausberg,R.L., Wagner,L., Pontius,J., Clifton,S.W.
            and Richardson,P.
  TITLE     Genetic and genomic tools for Xenopus research: The NIH Xenopus
            initiative
  JOURNAL   Dev Dyn 225 (4), 384-391 (2002)
   PUBMED   12454917
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC167699.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC167699.1, BC135908.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00028290, SAMD00028291
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..4223
                     /organism="Xenopus tropicalis"
                     /mol_type="mRNA"
                     /db_xref="taxon:8364"
                     /chromosome="8"
                     /map="8"
     gene            1..4223
                     /gene="pbx2"
                     /gene_synonym="g17; hox12; pbx2mhc"
                     /note="pre-B-cell leukemia homeobox 2"
                     /db_xref="GeneID:100101713"
                     /db_xref="Xenbase:XB-GENE-484669"
     exon            1..656
                     /gene="pbx2"
                     /gene_synonym="g17; hox12; pbx2mhc"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    406..408
                     /gene="pbx2"
                     /gene_synonym="g17; hox12; pbx2mhc"
                     /note="upstream in-frame stop codon"
     CDS             454..1722
                     /gene="pbx2"
                     /gene_synonym="g17; hox12; pbx2mhc"
                     /codon_start=1
                     /product="pre-B-cell leukemia transcription factor 2"
                     /protein_id="NP_001122133.1"
                     /db_xref="GeneID:100101713"
                     /db_xref="Xenbase:XB-GENE-484669"
                     /translation="

MDEQGRLMQARGVGIPGHPIHGGPQTLTPHPMHEPPADNGEPRKQDIGDILQQIMTITDQSLDEAQAKKHALNCHRMKPALFSVLCEIKEKTGLSIRNTQEEEPVDPQLMRLDNMLLAEGVAGPEKGGGSAAAAAAAAASGGVSPDNSIEHSDYRNKLSQIRQIYHAELEKYEQACNEFTTHVMNLLREQSRTRPISPKEIERMVGIIHRKFSSIQMQLKQSTCEAVMILRSRFLDARRKRRNFSKQATEVLNEYFYSHLSNPYPSEEAKEELAKKCGITVSQVSNWFGNKRIRYKKNIGKFQEEANIYAVKTAVSVAQGGHSGANSPTTPTSAGSGGSFNLSGSNDMFMAMQGLNGDSYPPSQVESLRHTMGPGYSDSLSANQMYSPREIRANGGWQEAVTPSSVTSPTEGPGSVHSDTSN"

     misc_feature    454..582
                     /gene="pbx2"
                     /gene_synonym="g17; hox12; pbx2mhc"
                     /note="propagated from UniProtKB/Swiss-Prot (B3DM47.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    589..1161
                     /gene="pbx2"
                     /gene_synonym="g17; hox12; pbx2mhc"
                     /note="PBC domain; Region: PBC; pfam03792"
                     /db_xref="CDD:461052"
     misc_feature    598..837
                     /gene="pbx2"
                     /gene_synonym="g17; hox12; pbx2mhc"
                     /note="propagated from UniProtKB/Swiss-Prot (B3DM47.1);
                     Region: PBC-A.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU01322"
     misc_feature    844..1161
                     /gene="pbx2"
                     /gene_synonym="g17; hox12; pbx2mhc"
                     /note="propagated from UniProtKB/Swiss-Prot (B3DM47.1);
                     Region: PBC-B.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU01322"
     misc_feature    1165..1347
                     /gene="pbx2"
                     /gene_synonym="g17; hox12; pbx2mhc"
                     /note="Homeodomain; DNA binding domains involved in the
                     transcriptional regulation of key eukaryotic developmental
                     processes; may bind to DNA as monomers or as homo- and/or
                     heterodimers, in a sequence-specific manner; Region:
                     homeodomain; cd00086"
                     /db_xref="CDD:238039"
     misc_feature    order(1165..1179,1183..1185,1243..1245,1261..1263,
                     1300..1302,1306..1311,1318..1323,1327..1335,1339..1344)
                     /gene="pbx2"
                     /gene_synonym="g17; hox12; pbx2mhc"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238039"
     misc_feature    order(1171..1173,1180..1182,1309..1311,1318..1323,
                     1330..1332)
                     /gene="pbx2"
                     /gene_synonym="g17; hox12; pbx2mhc"
                     /note="specific DNA base contacts [nucleotide binding];
                     other site"
                     /db_xref="CDD:238039"
     misc_feature    1408..1476
                     /gene="pbx2"
                     /gene_synonym="g17; hox12; pbx2mhc"
                     /note="propagated from UniProtKB/Swiss-Prot (B3DM47.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1510..1719
                     /gene="pbx2"
                     /gene_synonym="g17; hox12; pbx2mhc"
                     /note="propagated from UniProtKB/Swiss-Prot (B3DM47.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     exon            657..730
                     /gene="pbx2"
                     /gene_synonym="g17; hox12; pbx2mhc"
                     /inference="alignment:Splign:2.1.0"
     exon            731..975
                     /gene="pbx2"
                     /gene_synonym="g17; hox12; pbx2mhc"
                     /inference="alignment:Splign:2.1.0"
     exon            976..1166
                     /gene="pbx2"
                     /gene_synonym="g17; hox12; pbx2mhc"
                     /inference="alignment:Splign:2.1.0"
     exon            1167..1302
                     /gene="pbx2"
                     /gene_synonym="g17; hox12; pbx2mhc"
                     /inference="alignment:Splign:2.1.0"
     exon            1303..1456
                     /gene="pbx2"
                     /gene_synonym="g17; hox12; pbx2mhc"
                     /inference="alignment:Splign:2.1.0"
     exon            1457..1545
                     /gene="pbx2"
                     /gene_synonym="g17; hox12; pbx2mhc"
                     /inference="alignment:Splign:2.1.0"
     exon            1546..1629
                     /gene="pbx2"
                     /gene_synonym="g17; hox12; pbx2mhc"
                     /inference="alignment:Splign:2.1.0"
     exon            1630..4203
                     /gene="pbx2"
                     /gene_synonym="g17; hox12; pbx2mhc"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

ccattttacactcctcttttcccagcttcaatacagcgctactggctttttttagggatcccagaaaaaagcgaagcaggattgcaccccaccccaaaaatcatccggactgagctgtccgagtcttagcgatttagccgcccaggcgcgtcggacagtgcaacacggagcgatctatcggaggagccacttgaggagaaaggaagcctgggcgcgatctgtatacactgcctacagtcggggcttcgtaggcgctgctgggagaggaggcgaattccttccgagcaaatcgcatggtggaagcacagagcgatcagtagagcaggacgggactactcggggcaggaggagagttctatgaagggcagggggagttgtacaaggagacagagctgaggggacaagtgagaaacacacataaaaacaggagagcgatccctcgctggtgctcagatggatgaacaaggcaggctgatgcaggccaggggggtggggattccaggacaccccattcatggggggccccaaactctcactcctcatcctatgcatgaacccccggcagacaatggggagcccaggaaacaggatatcggtgacatattgcaacagatcatgactatcacggaccagagccttgatgaagcccaggcaaagaaacatgctttgaactgccacaggatgaaacctgcacttttcagtgtcctttgtgaaattaaagagaaaacagggttgagtattcgtaacacccaagaggaagagcctgttgaccctcagctcatgcgcttggacaatatgttactagcagaaggtgtagcaggaccagagaaaggtggtggatccgcggcagcggctgcagcagcagcagcttcaggtggagtctctcccgataattccattgagcactcggattacagaaacaaactgtcccaaatccgacagatttatcatgccgaactggagaagtatgagcaggcctgtaatgagttcacaacccatgtaatgaacctgttgagagagcagagccgaaccagacctatatcaccgaaggagatagagcgaatggttgggatcatccaccgaaagtttagttccattcagatgcagctcaagcagagtacctgtgaggctgtcatgatcctacgctcccgatttctggacgcacggaggaagagaagaaatttcagtaaacaagctactgaagtcttgaacgaatatttctactcacatctgagtaacccataccccagtgaggaggcaaaggaggagctggcaaagaagtgtggcataacagtgtcacaggtttcaaactggtttggaaacaagagaattaggtacaagaagaacattggaaagttccaggaagaggcaaatatctatgctgtgaagacagctgttagtgtggcacagggaggacacagtggggccaactccccaacaacccctacctctgcaggttctggtggttcattcaacctctctggatctaatgatatgttcatggcgatgcagggcttaaatggggattcttatcccccttcacaggtggagtccttgcgccacacgatgggccctggctacagtgatagtttgtcagcaaatcagatgtacagcccgcgggagatacgggcaaatggagggtggcaagaagctgtcaccccatcgtctgtcacctcccctacagaaggacctggcagtgtgcactctgacacctcgaactgagctctctcctctctgtgctccacctctctaccaaaccaggctctttacatggatataaccccttcctcaactaactcccgtaatctggaactaacggggaggaggattgtggaagaccactctccccttactcctctcttgcctcctattgctccttttaaaaagcccttggttcttccatcttttggaatagctgactaatggacagtaatggtctgcgttttttaaggaaataaggggttgagggcataacaccctatccctgttttaagggcagagactattgcccaaatactcccaaccaaaggatagtaatcgacccatcaccaagaagaaatccaaataaataccttgtaaagttcaagatggatgcccaacatggtatttttctgtatcgaaccaagaaagaagttatcatactgcccactagaaaaaaaaaagtgtcttgcccataagcaattatcctatagcacaataagaatcatatgtgtggatatgcttgaaggaggaaaaatataaaatgaagaattaacagggaataataaaccttatttcacatttaggggatggctttgaactcattctgtttgtagaacaggggaagaagagaggaaagtgttttaagaggtgtgaagaggacaaatgttaaaaggaggggcaagctagacaaagagagaaaggttaaagaaaatgggggatccagggaaaatgaggagagaaaaatgaaagaatgtaaaagccaaaacaaagagctacaaataaggactgttaaggtcaacgaaagactaaatctcctcactctctccctccagagtccacccaaaatcctttgaggctcagccaatcaaagaacagcgttattacctcatagcggctcacataaccaatagagaagactcttttctgtttattttttcctttctttttctgagttttctttttgttcacgcgttcgcaagtttgactacctccgaagggaaaataaaatatatataaatatatataaaaaaaactctctctcactcctgcacgggggcacagcaaagtgtgtggagaatttttctctaacttgatctgcttcccccttcactcccctttttttgttttgggaagttgggttatgaatagggttggtttttagagttttgtgtttagggaagtcttctaagggggcatttttattcttattttatttttggtgtgtgttgttggagaggaagttacagaaatgaagtagtaaggctgtgtgggtaacgctcagtgtctaacaaatcaaattgagcatttggtgcatcccttaaattttatacatttataccattaattattattttatgtgcatagatatttgaaacatacatcatgcttatttaggaacatgtgtatgtgtatatacatatataatgtgtgtgcattcataccaacaccacaaatctaaataaataattgcttggtgtttgtatctttatgcaaaggcagtaacatatgctgacgtataaatgtattaaaggacagattaaatcttaacactttttgagcaggcgtgtgattctggaattggtttagcacagccacagaatcccatgcacagacatgttccaaatcataaatgtattatatcatttctacatctgacatacacatttattagacacgcatttgcatataacaggttgactaaataatgaaaatgtatcagccaccaatgtgtagactcaacactgtttgacctcatgagttacattcacaaaaatactcacaaagataaggtggcaaaatccataaaattcagtgatagtctcagaatctgcctaaatcctgaatttagtgcatgcgttatatttatagggatgcactaaatgcttatttgtttctctaaactcaaggatatttcagaattttaaagataataggcacacaacatgttttatggcagtctgttcacttttgaccagacttacccaccatttatttgagtgcgcggtaaataccacaaaaaacattcctaatggatattctggacgatttggctgatgatcatgtaggctaatgaatgcagctttcagcggagcagcctaccaccatagccccttagtgatccatttaattgtctggatcagtttattaaaaggccagccagataaccgtcatctggctgcatattgtgcccatcttaggccttctaaaatatatgggaaaacacatggaatgtggatatttctaaatatgtcaagtgcagggacactcgagcacacagccttcctcttctgttctagcggcctggtcctgaatgctagactttgaggtgtgtgagattaggcaagatcttttcatatgtgtatattatacttttgtttgtttgtttaatttctctgccccatttagttgagggaaacctgtttatgaactgttattttggggttcttagaatattttttttttttctttcacaattattaaaaatgaatcactgacaaaccaaaaaaaaaaaaaaaaaaaaa

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