LOCUS       NM_001100223            1432 bp    mRNA    linear   VRT 16-APR-2022
DEFINITION  Xenopus tropicalis SIX homeobox 1 (six1), mRNA.
ACCESSION   NM_001100223
VERSION     NM_001100223.1
KEYWORDS    RefSeq.
SOURCE      Xenopus tropicalis (tropical clawed frog)
  ORGANISM  Xenopus tropicalis
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae;
            Xenopus; Silurana.
REFERENCE   1  (bases 1 to 1432)
  AUTHORS   Coppenrath K, Tavares ALP, Shaidani NI, Wlizla M, Moody SA and Horb
            M.
  TITLE     Generation of a new six1-null line in Xenopus tropicalis for study
            of development and congenital disease
  JOURNAL   Genesis 59 (12), e23453 (2021)
   PUBMED   34664392
  REMARK    GeneRIF: Generation of a new six1-null line in Xenopus tropicalis
            for study of development and congenital disease.
REFERENCE   2  (bases 1 to 1432)
  AUTHORS   Klein SL, Strausberg RL, Wagner L, Pontius J, Clifton SW and
            Richardson P.
  TITLE     Genetic and genomic tools for Xenopus research: The NIH Xenopus
            initiative
  JOURNAL   Dev Dyn 225 (4), 384-391 (2002)
   PUBMED   12454917
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC135608.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC135608.1, CX515554.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00028290, SAMD00028291
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1432
                     /organism="Xenopus tropicalis"
                     /mol_type="mRNA"
                     /db_xref="taxon:8364"
                     /chromosome="8"
                     /map="8"
     gene            1..1432
                     /gene="six1"
                     /gene_synonym="bos3; dfna23; tip39; XSix1"
                     /note="SIX homeobox 1"
                     /db_xref="GeneID:100101702"
                     /db_xref="Xenbase:XB-GENE-480717"
     exon            1..661
                     /gene="six1"
                     /gene_synonym="bos3; dfna23; tip39; XSix1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    96..98
                     /gene="six1"
                     /gene_synonym="bos3; dfna23; tip39; XSix1"
                     /note="upstream in-frame stop codon"
     CDS             102..956
                     /gene="six1"
                     /gene_synonym="bos3; dfna23; tip39; XSix1"
                     /note="sine oculis homeobox homolog 1"
                     /codon_start=1
                     /product="homeobox protein SIX1"
                     /protein_id="NP_001093693.1"
                     /db_xref="GeneID:100101702"
                     /db_xref="Xenbase:XB-GENE-480717"
                     /translation="

MSMLPSFGFTQEQVACVCEVLQQGGNLERLGRFLWSLPACDHLHKNESVLKAKAVVAFHRGNFRELYKILESHQFSPHNHPKLQQLWLKAHYVEAEKLRGRPLGAVGKYRVRRKFPLPRTIWDGEETSYCFKEKSRGVLREWYAHNPYPSPREKRELAEATGLTTTQVSNWFKNRRQRDRAAEAKERENTENNNTSSNKQNQLSPLDGGKSLMSSSEEEFSPPQSPDQNSVLLLQGSLTHPGGSSYSLSALSASQGGHGLQGHQHQLQDSLLGPLTSSLVDLGS"

     misc_feature    126..455
                     /gene="six1"
                     /gene_synonym="bos3; dfna23; tip39; XSix1"
                     /note="Transcriptional regulator, SIX1, N-terminal SD
                     domain; Region: SIX1_SD; pfam16878"
                     /db_xref="CDD:465293"
     misc_feature    486..641
                     /gene="six1"
                     /gene_synonym="bos3; dfna23; tip39; XSix1"
                     /note="Homeodomain; DNA binding domains involved in the
                     transcriptional regulation of key eukaryotic developmental
                     processes; may bind to DNA as monomers or as homo- and/or
                     heterodimers, in a sequence-specific manner; Region:
                     homeodomain; cd00086"
                     /db_xref="CDD:238039"
     misc_feature    order(489..491,609..611,618..623,630..632)
                     /gene="six1"
                     /gene_synonym="bos3; dfna23; tip39; XSix1"
                     /note="specific DNA base contacts [nucleotide binding];
                     other site"
                     /db_xref="CDD:238039"
     exon            662..1415
                     /gene="six1"
                     /gene_synonym="bos3; dfna23; tip39; XSix1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

gccagtactttccctgcgctcagagccgtggatatagcgtgtgctccccgtgtatgcctttacgtgtgcgctgtgggcccctggctgtgccacactgagccatgtctatgctgccttcctttggcttcactcaggagcaagtggcctgtgtgtgcgaggtgctgcagcagggaggcaacctggagagactgggcaggttcctatggtccttgccagcctgtgatcacctccacaagaatgagagtgtgctgaaggcaaaggccgtggtggcatttcacaggggcaacttcagagaactgtataagatactggagagccatcagttctccccgcacaaccaccccaaactgcagcaactctggctcaaggctcactatgtggaagcagagaaactgagggggagaccgctgggggcagtgggcaagtacagggtcagaaggaaattccccctgcccaggacaatctgggatggagaagagaccagttactgctttaaggagaagtcccgaggggtgctgagagaatggtatgcccataacccttacccgtctcccagggagaagcgggagctggctgaggccactggactaaccaccacccaggtcagcaattggttcaagaacaggaggcaaagggacagagcggcggaagcaaaagagagggaaaatacagaaaacaataacacatctagcaacaaacagaatcagctgtcacccctagatggaggaaagtcgctaatgtccagttcagaagaggaattctcccccccacagagcccggatcagaactctgtgctcctgttgcagggcagcctcacccaccccggcggctcctcttattccctgagcgctctcagcgcctcccagggcggccatggcctacaggggcaccagcaccagctgcaggactctctgcttgggcccctcacctccagcctggtggatctgggatcgtaagagcgaccgccggactcagccatggactgcactcttattgtacatagcaaggcactcatctcatggtacttaatgtggaaaggaaactgggactttttatacttttcttcggtacaatcaatcccacacagcaccccgcaccgctgaatgctcttacgttacggcctcctgtggcactcatataccctcttcccccaaattgctgtaacaaaatactgtataggagataccacaaggatataactgtgtcttatttatgaacacccctcccccccaaaaaaacaatgtggttaaacatgggaaatctggagagaattgctgtttgctcccactgtgacacctagaataattgcccagctatttggaggcgctaagtttacatttccccccacatttagtgttgaaagaagattgcaaagtagtttataataaaatacagtattagaaagtacaaaccaaaaaaaaaaaaaaaaaaa

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