LOCUS       NM_001016021            2162 bp    mRNA    linear   VRT 02-FEB-2024
DEFINITION  Xenopus tropicalis cone-rod homeobox (crx), mRNA.
ACCESSION   NM_001016021
VERSION     NM_001016021.2
KEYWORDS    RefSeq.
SOURCE      Xenopus tropicalis (tropical clawed frog)
  ORGANISM  Xenopus tropicalis
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae;
            Xenopus; Silurana.
REFERENCE   1  (bases 1 to 2162)
  AUTHORS   Klein,S.L., Strausberg,R.L., Wagner,L., Pontius,J., Clifton,S.W.
            and Richardson,P.
  TITLE     Genetic and genomic tools for Xenopus research: The NIH Xenopus
            initiative
  JOURNAL   Dev Dyn 225 (4), 384-391 (2002)
   PUBMED   12454917
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CR848167.2.
            
            On Oct 14, 2005 this sequence version replaced NM_001016021.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CR848167.2, BC085002.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00861986, SAMN00861998
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2162
                     /organism="Xenopus tropicalis"
                     /mol_type="mRNA"
                     /db_xref="taxon:8364"
                     /chromosome="8"
                     /map="8"
     gene            1..2162
                     /gene="crx"
                     /gene_synonym="cord2; crd; crx-a; crx-b; otx5; otx5b; rx;
                     Xotx5; Xotx5b"
                     /note="cone-rod homeobox"
                     /db_xref="GeneID:548775"
                     /db_xref="Xenbase:XB-GENE-478452"
     exon            1..218
                     /gene="crx"
                     /gene_synonym="cord2; crd; crx-a; crx-b; otx5; otx5b; rx;
                     Xotx5; Xotx5b"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    104..106
                     /gene="crx"
                     /gene_synonym="cord2; crd; crx-a; crx-b; otx5; otx5b; rx;
                     Xotx5; Xotx5b"
                     /note="upstream in-frame stop codon"
     CDS             122..994
                     /gene="crx"
                     /gene_synonym="cord2; crd; crx-a; crx-b; otx5; otx5b; rx;
                     Xotx5; Xotx5b"
                     /note="orthodenticle homolog 5"
                     /codon_start=1
                     /product="homeobox protein otx5"
                     /protein_id="NP_001016021.1"
                     /db_xref="GeneID:548775"
                     /db_xref="Xenbase:XB-GENE-478452"
                     /translation="

MMSYIKQPHYAVNGLTLAGTGMDLLHSAVGYPTTPRKQRRERTTFTRAQLDILEALFAKTRYPDIFMREEVALKINLPESRVQVWFKNRRAKCRQQQQQSTGQAKPRPAKKKTSPARETNSEASTNGQYSPPPPGTAVTPSSTASATVSIWSPASISPIPDPLSAATTPCMQRSAGYPMTYSQAPAYTQSYGGSSSYFTGLDCGSYLSPMHPQLSAPGATLSPIATPTMGSHLSQSPASLSAQGYGASSLGFTSVDCLDYKDQTASWKLNFNATDCLDYKDQSSWKFQVL"

     misc_feature    236..403
                     /gene="crx"
                     /gene_synonym="cord2; crd; crx-a; crx-b; otx5; otx5b; rx;
                     Xotx5; Xotx5b"
                     /note="Region: Homeodomain; pfam00046"
                     /db_xref="CDD:459649"
     misc_feature    398..553
                     /gene="crx"
                     /gene_synonym="cord2; crd; crx-a; crx-b; otx5; otx5b; rx;
                     Xotx5; Xotx5b"
                     /note="propagated from UniProtKB/Swiss-Prot (Q28EM7.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    575..829
                     /gene="crx"
                     /gene_synonym="cord2; crd; crx-a; crx-b; otx5; otx5b; rx;
                     Xotx5; Xotx5b"
                     /note="Otx1 transcription factor; Region: TF_Otx;
                     pfam03529"
                     /db_xref="CDD:427350"
     exon            219..370
                     /gene="crx"
                     /gene_synonym="cord2; crd; crx-a; crx-b; otx5; otx5b; rx;
                     Xotx5; Xotx5b"
                     /inference="alignment:Splign:2.1.0"
     exon            371..2146
                     /gene="crx"
                     /gene_synonym="cord2; crd; crx-a; crx-b; otx5; otx5b; rx;
                     Xotx5; Xotx5b"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2144
                     /gene="crx"
                     /gene_synonym="cord2; crd; crx-a; crx-b; otx5; otx5b; rx;
                     Xotx5; Xotx5b"
ORIGIN      

cagattcagctgagagaagacctgtatctggatcaactgagagtaaagaaactctgatttcaggctagcataccacaaaaatatcaagtttattgaagtcccctgaaactcggccactgaaatgatgtcctacattaaacaacctcattatgcagtcaatggacttactctagctggtactggaatggaccttctgcactcagctgtaggatacccaacaaccccacggaaacaaagaagagagagaacaacttttaccagggcccagctggatattttggaagccctctttgctaaaacacgctaccctgacattttcatgagggaggaggtggctctaaagataaatctaccagagtcccgagtgcaggtctggtttaaaaatagaagggcaaaatgtcgccagcaacaacagcagagcaccggacaagctaagcctcgaccagctaagaagaaaacttcccctgccagggagaccaattcagaggcaagcaccaatgggcagtacagtcctcctcctcctggcactgcagttacccctagttccacagctagtgcaacagtgtccatatggagtccagcctccatatcccccattcctgatcctctctctgctgcgactactccctgcatgcagaggtcagctggctatccaatgacctatagtcaggcccctgcttatactcagagctatggaggatcttcatcttatttcacagggctggactgtggatcctatctatctcctatgcacccacagctctcagctcctggtgccacattgagcccaattgccacgcctacgatgggtagccaccttagccaatctccggcatccctttccgcccagggatatggagcttccagtcttggcttcacctcagtggattgcttagactacaaagaccaaactgcttcctggaagctaaacttcaatgccactgactgccttgattataaagaccagagctcatggaaatttcaggtcttgtagatatgactgaagtccaagcctcattttcatcatcctcaacttcagtataaactgtgcttcatatttcagctttacaagagtggcttgactggatatctaacgatggaacaaacacaaaaacattaataactttatatctttatgccattaactcttttagaacaaattgcctgtacaactccacagtttgaaaccacacaaatgtctgtaaaaacacagcacaccaagcttattttcttttttaatctgaaaaacataaagttttgataaaatgacaacaaatgtaggggagatcattttaaaagcactttggcctgaggaagctatgataacagttccttactcccctatcttgttgttgattgggaaatttgttgtgataaaataatcaggtttttggcattaaacctgttttgctgcacattttgcttactctgccctagccaccaaagataattcagtaatctctggagtaaaagtgttctccagatatctaccaaagtttcaaaatgagatgtgactcaacacagccattccttatctttccaatttcttaacccttataatgcatatttgaactttaatttaaattgatatctgataacgcacagaagttcatcaggtgcatatgagccacctactgcaaaacctgtatttaaagcccccctaccaacagtgaaaaagaatgaaaagtaatctgctctgttcagtttaggacacaatgcctgaaaggcacaaccttctgcagattctgaaatccaatcaagctaaacaatagcaggctcctcatgtaccagagctaacacaatcactgtagttcattacaagcattgttcatttatttgaacaagcataaacttgagactcacaactaaccaatgatatttttgaatggagttaatttattttataaaaggtttctacctatccaccgctgtatgatttgtcataccatggaatactataaatgagaagtgtttttctgtgttgtgctttagtctttgtgttaactagcaaagttctatataggggtttatgtctgtcccagcaaatcagtacaaactttcttttagttctgtaatattaattaattaatgttatgacaaaaaatataaatgtgcaaaatattaaaattattgtgttaaaccacaaaaaaaaaaaaaaaaaa

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