LOCUS       NM_001008052            2007 bp    mRNA    linear   VRT 26-APR-2024
DEFINITION  Xenopus tropicalis SRY-box 11 (sox11), mRNA.
ACCESSION   NM_001008052
VERSION     NM_001008052.1
KEYWORDS    RefSeq.
SOURCE      Xenopus tropicalis (tropical clawed frog)
  ORGANISM  Xenopus tropicalis
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae;
            Xenopus; Silurana.
REFERENCE   1  (bases 1 to 2007)
  AUTHORS   Hempel,A., Pagnamenta,A.T., Blyth,M., Mansour,S., McConnell,V.,
            Kou,I., Ikegawa,S., Tsurusaki,Y., Matsumoto,N., Lo-Castro,A.,
            Plessis,G., Albrecht,B., Battaglia,A., Taylor,J.C., Howard,M.F.,
            Keays,D., Sohal,A.S., Kuhl,S.J., Kini,U. and McNeill,A.
  CONSRTM   DDD Collaboration
  TITLE     Deletions and de novo mutations of SOX11 are associated with a
            neurodevelopmental disorder with features of Coffin-Siris syndrome
  JOURNAL   J Med Genet 53 (3), 152-162 (2016)
   PUBMED   26543203
REFERENCE   2  (bases 1 to 2007)
  AUTHORS   Cizelsky,W., Hempel,A., Metzig,M., Tao,S., Hollemann,T., Kuhl,M.
            and Kuhl,S.J.
  TITLE     sox4 and sox11 function during Xenopus laevis eye development
  JOURNAL   PLoS One 8 (7), e69372 (2013)
   PUBMED   23874955
  REMARK    GeneRIF: Sox4 and Sox11 are required for Xenopus visual system
            development.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2007)
  AUTHORS   Klein,S.L., Strausberg,R.L., Wagner,L., Pontius,J., Clifton,S.W.
            and Richardson,P.
  TITLE     Genetic and genomic tools for Xenopus research: The NIH Xenopus
            initiative
  JOURNAL   Dev Dyn 225 (4), 384-391 (2002)
   PUBMED   12454917
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC080939.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC080939.1 [ECO:0000332]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2007
                     /organism="Xenopus tropicalis"
                     /mol_type="mRNA"
                     /db_xref="taxon:8364"
                     /chromosome="5"
                     /map="5"
     gene            1..2007
                     /gene="sox11"
                     /gene_synonym="sox11-a; sox11-b; XLS13; xls13a; XLS13b;
                     xSOX-11; xsox11"
                     /note="SRY-box 11"
                     /db_xref="GeneID:493415"
                     /db_xref="Xenbase:XB-GENE-483418"
     exon            1..2007
                     /gene="sox11"
                     /gene_synonym="sox11-a; sox11-b; XLS13; xls13a; XLS13b;
                     xSOX-11; xsox11"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    19..21
                     /gene="sox11"
                     /gene_synonym="sox11-a; sox11-b; XLS13; xls13a; XLS13b;
                     xSOX-11; xsox11"
                     /note="upstream in-frame stop codon"
     CDS             91..1242
                     /gene="sox11"
                     /gene_synonym="sox11-a; sox11-b; XLS13; xls13a; XLS13b;
                     xSOX-11; xsox11"
                     /note="SRY (sex determining region Y)-box 11"
                     /codon_start=1
                     /product="transcription factor Sox-11"
                     /protein_id="NP_001008053.1"
                     /db_xref="GeneID:493415"
                     /db_xref="Xenbase:XB-GENE-483418"
                     /translation="

MVQQADSLDMDSSQHTEPDTEEGEFMACSPVALDESDPDWCKTATGHIKRPMNAFMVWSKIERRKIMEQSPDMHNAEISKRLGKRWKMLNDSEKIPFIREAERLRLKHMADYPDYKYRPRKKPKVDPSASKPASLAQSPEKSPKSRSAGKKCPKLKPGSHSGSSSSSGSAKSLTIKSEYGGDDYVFGSPKAASKAAKCVFMDEDDEEEEEDEEEDELQIRIKQEEEDEPLRQYNVAKVPASPTLSSSSAESAEGASMYEDVRNGTRLYYNFKNITKQSTIPQATITLAPAPRSAGTTSPSSHKDELMFDLSLNFTQQNPPVPELGNPNSGNLSLSLVDKDLDSCSEGSLGSHFDFPDYCTPELSEMIAGDWLEANFSDLVFTY"

     misc_feature    91..162
                     /gene="sox11"
                     /gene_synonym="sox11-a; sox11-b; XLS13; xls13a; XLS13b;
                     xSOX-11; xsox11"
                     /note="propagated from UniProtKB/Swiss-Prot (Q66JF1.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    199..474
                     /gene="sox11"
                     /gene_synonym="sox11-a; sox11-b; XLS13; xls13a; XLS13b;
                     xSOX-11; xsox11"
                     /note="high mobility group (HMG)-box found in sex
                     determining region Y (SRY)-box 11 (SOX11) and similar
                     proteins; Region: HMG-box_SoxC_SOX11; cd22037"
                     /db_xref="CDD:438846"
     misc_feature    order(229..231,235..240,244..249,253..258,268..270,
                     277..279,289..291,310..318,325..330,337..339,346..351,
                     403..405,439..441,445..453)
                     /gene="sox11"
                     /gene_synonym="sox11-a; sox11-b; XLS13; xls13a; XLS13b;
                     xSOX-11; xsox11"
                     /note="putative DNA binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:438846"
     misc_feature    433..612
                     /gene="sox11"
                     /gene_synonym="sox11-a; sox11-b; XLS13; xls13a; XLS13b;
                     xSOX-11; xsox11"
                     /note="propagated from UniProtKB/Swiss-Prot (Q66JF1.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    679..783
                     /gene="sox11"
                     /gene_synonym="sox11-a; sox11-b; XLS13; xls13a; XLS13b;
                     xSOX-11; xsox11"
                     /note="propagated from UniProtKB/Swiss-Prot (Q66JF1.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
ORIGIN      

gggaagcggggctctgtgtaaggcgctggcactacagtagcagcacctcagcgcctcagccaaagccaagtagtccgcacagtgacagcaatggtgcagcaagccgacagcctggacatggacagcagccagcacactgagcccgacacggaggaaggggagtttatggcgtgcagcccggtggctctggatgagagcgacccagactggtgtaaaacagccaccgggcacatcaagcggcccatgaacgccttcatggtctggtccaagatagagcggcggaagatcatggagcagtccccggacatgcacaacgccgagatctccaagcgcctggggaagcgctggaaaatgctcaacgacagcgagaaaatccccttcatcagggaagccgagcggctgcggctcaaacacatggccgattatcccgactacaagtaccggcccaggaaaaagcccaaagtggatccttcagcctccaagccggcctctctggctcagtccccggagaagagccccaagagccggagcgcaggcaagaaatgccccaagctaaagcccggcagccacagcggcagcagcagctcctccggctccgccaagtcgctcaccatcaagtccgagtacggcggcgacgactatgtcttcggcagccccaaggcggcgagcaaggcggccaaatgcgtcttcatggacgaggacgatgaggaggaggaggaagacgaagaggaggacgagctgcagattcggatcaagcaggaggaggaggacgagccgctgcgacaatacaatgtggccaaagtaccggccagcccgaccttgagctcttcatcggccgagtcggcggaaggcgccagcatgtatgaggatgttcggaacggaaccagactctattacaacttcaagaacataacgaagcaaagcacaatcccccaagccaccatcaccctggccccggccccccgatctgccggcactacctcacccagcagccacaaggacgagctcatgttcgatctcagtttgaacttcacccagcagaaccctccggtaccggagcttgggaaccccaactcaggaaacctctccctctccctggtggacaaggacttggactcatgcagtgagggcagcctgggctcccacttcgatttcccagattactgcactcccgaactcagcgagatgatcgcaggggactggttggaagccaacttttcagacttggtattcacttactgaaatgagtgttttttttttttgttaataattattattattattgattcctaaaaaattctggtggggaggggaatctccagagaaatggatgagggccacacaaattctttgagctccatcaacgtctcggtacagattaaagggctgttcttgcatcttttttttatatatatatataaacgtccagcctttgaatttttgggcgatcactgtagaaggaagaggatgaggagggccaatggacataggggaatgaagaaaaggagattgttttaaaaaaaaaaaaaacacaagcggtctggaaaatggtctggcagaacaaaaatgtcttatttcttggcagctcaagggggggggggggcactttttattattttttaatgttattctgctggaaaaaggaactgacaacaagatttttttttatttttcgtttctggaaggagaaaaaaaaactgatctcttctatgcatctgattctcaatctgcagggagttgcaacatgcagacaggactacacaactgctacactacacaaacacacaactacagaactgtgaactgattctcaactcagagagtttacttcttacaggtcaaacaccaatgtacaggtttttttttgttcttctctggtcacaatgtgatttttacttgccaacaactactttataatttttttttttattattatttgtaaccggttccctttattacctccttgaatccagacaacccagacctcagtacaaaaaaaaaaaaaaa

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