LOCUS       NM_001006781            2413 bp    mRNA    linear   VRT 03-APR-2024
DEFINITION  Xenopus tropicalis Meis homeobox 3 (meis3), mRNA.
ACCESSION   NM_001006781
VERSION     NM_001006781.1
KEYWORDS    RefSeq.
SOURCE      Xenopus tropicalis (tropical clawed frog)
  ORGANISM  Xenopus tropicalis
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae;
            Xenopus; Silurana.
REFERENCE   1  (bases 1 to 2413)
  AUTHORS   Elkouby,Y.M., Elias,S., Casey,E.S., Blythe,S.A., Tsabar,N.,
            Klein,P.S., Root,H., Liu,K.J. and Frank,D.
  TITLE     Mesodermal Wnt signaling organizes the neural plate via Meis3
  JOURNAL   Development 137 (9), 1531-1541 (2010)
   PUBMED   20356957
  REMARK    GeneRIF: Data show that Meis3 is a direct target of
            Wnt/beta-catenin signaling.
REFERENCE   2  (bases 1 to 2413)
  AUTHORS   Klein,S.L., Strausberg,R.L., Wagner,L., Pontius,J., Clifton,S.W.
            and Richardson,P.
  TITLE     Genetic and genomic tools for Xenopus research: The NIH Xenopus
            initiative
  JOURNAL   Dev Dyn 225 (4), 384-391 (2002)
   PUBMED   12454917
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC075589.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC075589.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00028290, SAMD00028291
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2413
                     /organism="Xenopus tropicalis"
                     /mol_type="mRNA"
                     /db_xref="taxon:8364"
                     /chromosome="8"
                     /map="8"
     gene            1..2413
                     /gene="meis3"
                     /gene_synonym="meis1; meis3-a; meis3-b; mrg2; XMeis3"
                     /note="Meis homeobox 3"
                     /db_xref="GeneID:448474"
                     /db_xref="Xenbase:XB-GENE-485337"
     exon            1..28
                     /gene="meis3"
                     /gene_synonym="meis1; meis3-a; meis3-b; mrg2; XMeis3"
                     /inference="alignment:Splign:2.1.0"
     exon            29..402
                     /gene="meis3"
                     /gene_synonym="meis1; meis3-a; meis3-b; mrg2; XMeis3"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    181..183
                     /gene="meis3"
                     /gene_synonym="meis1; meis3-a; meis3-b; mrg2; XMeis3"
                     /note="upstream in-frame stop codon"
     CDS             391..1752
                     /gene="meis3"
                     /gene_synonym="meis1; meis3-a; meis3-b; mrg2; XMeis3"
                     /note="Meis1, myeloid ecotropic viral integration site 1
                     homolog"
                     /codon_start=1
                     /product="homeobox protein meis3"
                     /protein_id="NP_001006782.1"
                     /db_xref="GeneID:448474"
                     /db_xref="Xenbase:XB-GENE-485337"
                     /translation="

MAQRYDEMVHYPGLDGMPLAGFGDAHTGRALQHHSLSQSAPYGSTGAAHRVPMPPGMGSNDGLKREKDEIYGHPLFPLLALVFEKCELATCSPRDNSGSFPGGDVCSSDSFNEDIAVFAKQVRTEKPLFSSNPELDSLMIQAIQVLRFHLLELEKVHDLCDNFCHRYITCLKGKMPIDLVIDDRDGSSKSDLEDFTGSCTSLSDQNNSWIRDHDETGSTHSGTPGPSSGGLASQSGDNSSEQGDCMDNSVASPSTGDDDDLDRDKKRNKKRGIFPKVATNIMRAWLFQHLSHPYPSEEQKKQLAQDTGLTILQVNNWFINARRRIVQPMIDQSNRTGQGGAPYSPDGQNMGGYVMDGQQHMGIRPPGFQGIPGDYTAAPSTMPMGFPPAGYTPAIPPHSAGLRHGPSLHSYLPGHPHHASMILPAGTSPHHLVSAQSPADALLNGQNIDIHAH"

     misc_feature    487..582
                     /gene="meis3"
                     /gene_synonym="meis1; meis3-a; meis3-b; mrg2; XMeis3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6DIF3.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    694..948
                     /gene="meis3"
                     /gene_synonym="meis1; meis3-a; meis3-b; mrg2; XMeis3"
                     /note="N-terminal of Homeobox Meis and PKNOX1; Region:
                     Meis_PKNOX_N; pfam16493"
                     /db_xref="CDD:465140"
     misc_feature    964..1206
                     /gene="meis3"
                     /gene_synonym="meis1; meis3-a; meis3-b; mrg2; XMeis3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6DIF3.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    order(1195..1206,1210..1212,1270..1272,1288..1290,
                     1327..1329,1333..1338,1345..1350,1354..1362)
                     /gene="meis3"
                     /gene_synonym="meis1; meis3-a; meis3-b; mrg2; XMeis3"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238039"
     misc_feature    order(1198..1200,1207..1209,1336..1338,1345..1350,
                     1357..1359)
                     /gene="meis3"
                     /gene_synonym="meis1; meis3-a; meis3-b; mrg2; XMeis3"
                     /note="specific DNA base contacts [nucleotide binding];
                     other site"
                     /db_xref="CDD:238039"
     misc_feature    1246..1362
                     /gene="meis3"
                     /gene_synonym="meis1; meis3-a; meis3-b; mrg2; XMeis3"
                     /note="Homeobox KN domain; Region: Homeobox_KN; pfam05920"
                     /db_xref="CDD:428673"
     exon            403..605
                     /gene="meis3"
                     /gene_synonym="meis1; meis3-a; meis3-b; mrg2; XMeis3"
                     /inference="alignment:Splign:2.1.0"
     exon            606..753
                     /gene="meis3"
                     /gene_synonym="meis1; meis3-a; meis3-b; mrg2; XMeis3"
                     /inference="alignment:Splign:2.1.0"
     exon            754..804
                     /gene="meis3"
                     /gene_synonym="meis1; meis3-a; meis3-b; mrg2; XMeis3"
                     /inference="alignment:Splign:2.1.0"
     exon            805..855
                     /gene="meis3"
                     /gene_synonym="meis1; meis3-a; meis3-b; mrg2; XMeis3"
                     /inference="alignment:Splign:2.1.0"
     exon            856..1005
                     /gene="meis3"
                     /gene_synonym="meis1; meis3-a; meis3-b; mrg2; XMeis3"
                     /inference="alignment:Splign:2.1.0"
     exon            1006..1117
                     /gene="meis3"
                     /gene_synonym="meis1; meis3-a; meis3-b; mrg2; XMeis3"
                     /inference="alignment:Splign:2.1.0"
     exon            1118..1263
                     /gene="meis3"
                     /gene_synonym="meis1; meis3-a; meis3-b; mrg2; XMeis3"
                     /inference="alignment:Splign:2.1.0"
     exon            1264..1340
                     /gene="meis3"
                     /gene_synonym="meis1; meis3-a; meis3-b; mrg2; XMeis3"
                     /inference="alignment:Splign:2.1.0"
     exon            1341..1399
                     /gene="meis3"
                     /gene_synonym="meis1; meis3-a; meis3-b; mrg2; XMeis3"
                     /inference="alignment:Splign:2.1.0"
     exon            1400..1489
                     /gene="meis3"
                     /gene_synonym="meis1; meis3-a; meis3-b; mrg2; XMeis3"
                     /inference="alignment:Splign:2.1.0"
     exon            1490..2393
                     /gene="meis3"
                     /gene_synonym="meis1; meis3-a; meis3-b; mrg2; XMeis3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

caagaactgagcatcctccaggaggaaggaaggcaaagaaagggggtgcactgactggagcactaagagaggaggctgtttggggggctgccgtttgcacacctccctcctccttcactccccccacccactgctcctgaagatcatcagtcatttggattttgacagatcttgcaaccttgatggacaggcagaaagagcagctttaagataccaagagaggagaggggggaacgcacagctcctgtggctctccatgctccagtctccagcttgggcttctccctggactcaggtcccaccttgttcccttgcactgagggcacttccagtcttgtccaggaacagctgcccttcttccacaagtctcccaggcggacccgactcggaatggcacaaaggtatgatgagatggtgcattacccaggattggatgggatgcctctggcaggatttggggatgcccacacaggccgagcactacagcaccactcacttagtcagagtgcaccctatggatctacaggagcagctcaccgagtaccaatgccccctggaatgggcagcaacgatggtctgaaaagagagaaggatgagatttatgggcaccctctgtttcctctgctggctttggtgttcgagaagtgcgaattggctacgtgttccccccgcgacaattcagggtcattcccagggggtgatgtttgctcttcagattcttttaacgaagatatcgctgtttttgccaaacaggtcagaacagaaaaaccccttttctcttccaacccagagctggacagtttgatgatacaagccattcaagttttacgattccacctgttggagttagaaaaggttcatgatctatgtgacaatttctgccatcggtatatcacatgtcttaaaggcaagatgcccattgatttagttatagatgatcgcgatggttcttccaagtctgatctggaagatttcacaggttcctgcaccagcctatcagaccagaataactcatggatacgagatcatgacgagacaggctcgactcactcaggtacaccgggtccttccagcggagggctagcttcccaaagtggagataattccagtgaacagggtgactgtatggataacagtgtggcatcgccgagcacaggggatgacgacgacttagatagagacaagaagaggaacaaaaaaagaggcatttttcccaaagttgccacaaacataatgagggcgtggctctttcagcacctctcgcacccttacccctctgaagaacagaaaaagcagctagcacaggatacagggctcacgatattacaggtcaacaattggtttattaatgcaagaagacgcatcgtccaacctatgattgaccagtctaatcgcacagggcaaggaggagctccctacagcccagatggtcagaacatgggaggatatgtcatggatggacaacaacacatgggcattcgacccccaggcttccaaggaattcctggggattacacagcagccccaagcactatgcccatgggattcccaccggctgggtacacacctgccataccgccacactcagctggtcttcgccacggaccgtctttacactcctacctcccagggcaccctcaccacgcctctatgattctgccagctggcacctccccacaccacctggtttcagcgcagagtccggcggacgcacttctaaatggtcaaaacatagacattcacgctcactaatattggacaccttgggcgttagttcagtgacatttttattttacctccaacctcagttttttaaagggtgttggctaaacttcatatgcttgttctgcaaaaggaataaagcaagtgttcaagcctttatccagctaactgtagctgcagagtggttagaaacaagtggatgataacaggacattcaagagaaaggacacaggatggaagccattcaggtggaagagaaacaatggcaaagttaagccaaatgggcagtggcccttcctgggagtctgcgtgaagtcatatccaaggaaggaataacagtctaatggaggagaagaaacattctttttaagcacacccttcattcccactatttgtttttggaaggaccaagacaagatgttcatgtatggacagatgaactgtgatttacatttttagggacttttttttttttcttttatcttgtcacttgaagcagggactacgttaacttgtacatttttaagtaatataattatttgggttgatacatgtcttgttttacctgttttttatgataaaggaaaagaacttgaaaacaaaatgccactgtggatgtatatacatatgtaaaaatatttatagcacctataaaattcagggtaagcagaaaaaaaaaaaaaaaaaaaaa

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