LOCUS       NM_001001903            2408 bp    mRNA    linear   VRT 29-MAY-2023
DEFINITION  Xenopus tropicalis tumor protein p53 (tp53), mRNA.
ACCESSION   NM_001001903
VERSION     NM_001001903.1
KEYWORDS    RefSeq.
SOURCE      Xenopus tropicalis (tropical clawed frog)
  ORGANISM  Xenopus tropicalis
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae;
            Xenopus; Silurana.
REFERENCE   1  (bases 1 to 2408)
  AUTHORS   Shi Z, Liu G, Jiang H, Shi S, Zhang X, Deng Y and Chen Y.
  TITLE     Activation of P53 pathway contributes to Xenopus hybrid inviability
  JOURNAL   Proc Natl Acad Sci U S A 120 (21), e2303698120 (2023)
   PUBMED   37186864
  REMARK    GeneRIF: Activation of P53 pathway contributes to Xenopus hybrid
            inviability.
REFERENCE   2  (bases 1 to 2408)
  AUTHORS   Ran R, Li L, Shi Z, Liu G, Jiang H, Fang L, Xu T, Huang J, Chen W
            and Chen Y.
  TITLE     Disruption of tp53 leads to cutaneous nevus and melanoma formation
            in Xenopus tropicalis
  JOURNAL   Mol Oncol 16 (19), 3554-3567 (2022)
   PUBMED   35981147
  REMARK    GeneRIF: Disruption of tp53 leads to cutaneous nevus and melanoma
            formation in Xenopus tropicalis.
REFERENCE   3  (bases 1 to 2408)
  AUTHORS   Rana AA, Collart C, Gilchrist MJ and Smith JC.
  TITLE     Defining synphenotype groups in Xenopus tropicalis by use of
            antisense morpholino oligonucleotides
  JOURNAL   PLoS Genet 2 (11), e193 (2006)
   PUBMED   17112317
REFERENCE   4  (bases 1 to 2408)
  AUTHORS   Klein SL, Strausberg RL, Wagner L, Pontius J, Clifton SW and
            Richardson P.
  TITLE     Genetic and genomic tools for Xenopus research: The NIH Xenopus
            initiative
  JOURNAL   Dev Dyn 225 (4), 384-391 (2002)
   PUBMED   12454917
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC069046.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC069046.1, CU075781.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00028290, SAMD00028291
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2408
                     /organism="Xenopus tropicalis"
                     /mol_type="mRNA"
                     /db_xref="taxon:8364"
                     /chromosome="3"
                     /map="3"
     gene            1..2408
                     /gene="tp53"
                     /gene_synonym="lfs1; p53; Trp248; trp53; Xp53; Xrel3"
                     /note="tumor protein p53"
                     /db_xref="GeneID:431679"
                     /db_xref="Xenbase:XB-GENE-484286"
     exon            1..70
                     /gene="tp53"
                     /gene_synonym="lfs1; p53; Trp248; trp53; Xp53; Xrel3"
                     /inference="alignment:Splign:2.1.0"
     exon            71..156
                     /gene="tp53"
                     /gene_synonym="lfs1; p53; Trp248; trp53; Xp53; Xrel3"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    71..73
                     /gene="tp53"
                     /gene_synonym="lfs1; p53; Trp248; trp53; Xp53; Xrel3"
                     /note="upstream in-frame stop codon"
     CDS             86..1174
                     /gene="tp53"
                     /gene_synonym="lfs1; p53; Trp248; trp53; Xp53; Xrel3"
                     /note="Li-Fraumeni syndrome; tumor suppressor p53"
                     /codon_start=1
                     /product="cellular tumor antigen p53"
                     /protein_id="NP_001001903.1"
                     /db_xref="GeneID:431679"
                     /db_xref="Xenbase:XB-GENE-484286"
                     /translation="

MEPSSETGMEPPLSQETFEDLWSLLPDPLQTGTGQMENFAEFSEYPLAPDMTVLQEGLMGNTVPTVTSSAVPSTEDYAGSYGLKLEFQQNGTAKSVTCTYSTDLNKLFCQLAKTCPLLVRVERPPPLGSILRATAVYKKSEHVAEVVKRCPHHERSVEPGDDPAPPSHLMRVEGNSKAYYMEDVGTGRHSVCVPYEGPQVGTECTTVLYNYMCNSSCMGGMNRRPILTIITLESPEGLLLGRRCFEVRVCACPGRDRRTEEDNCTKKRGLKPNGKRELSHPPSSDPPLPKKRLVEEDDEETFTLLIKGRSRYEMIKKLNDALELQESLDQQKLSIKCRKCRDEIKPKKGKKLLVKDELQDSE"

     misc_feature    98..169
                     /gene="tp53"
                     /gene_synonym="lfs1; p53; Trp248; trp53; Xp53; Xrel3"
                     /note="P53 transactivation motif; Region: P53_TAD;
                     pfam08563"
                     /db_xref="CDD:462520"
     misc_feature    335..877
                     /gene="tp53"
                     /gene_synonym="lfs1; p53; Trp248; trp53; Xp53; Xrel3"
                     /note="P53 DNA-binding domain; Region: P53; cd08367"
                     /db_xref="CDD:176262"
     misc_feature    order(533..535,542..544,722..724,734..736)
                     /gene="tp53"
                     /gene_synonym="lfs1; p53; Trp248; trp53; Xp53; Xrel3"
                     /note="zinc binding site [ion binding]; other site"
                     /db_xref="CDD:176262"
     misc_feature    order(536..544,548..550)
                     /gene="tp53"
                     /gene_synonym="lfs1; p53; Trp248; trp53; Xp53; Xrel3"
                     /note="dimerization site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:176262"
     misc_feature    order(725..727,731..733,752..754,827..829,833..841,
                     848..850)
                     /gene="tp53"
                     /gene_synonym="lfs1; p53; Trp248; trp53; Xp53; Xrel3"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:176262"
     misc_feature    953..1081
                     /gene="tp53"
                     /gene_synonym="lfs1; p53; Trp248; trp53; Xp53; Xrel3"
                     /note="P53 tetramerization motif; Region: P53_tetramer;
                     pfam07710"
                     /db_xref="CDD:462238"
     exon            157..205
                     /gene="tp53"
                     /gene_synonym="lfs1; p53; Trp248; trp53; Xp53; Xrel3"
                     /inference="alignment:Splign:2.1.0"
     exon            206..382
                     /gene="tp53"
                     /gene_synonym="lfs1; p53; Trp248; trp53; Xp53; Xrel3"
                     /inference="alignment:Splign:2.1.0"
     exon            383..569
                     /gene="tp53"
                     /gene_synonym="lfs1; p53; Trp248; trp53; Xp53; Xrel3"
                     /inference="alignment:Splign:2.1.0"
     exon            570..682
                     /gene="tp53"
                     /gene_synonym="lfs1; p53; Trp248; trp53; Xp53; Xrel3"
                     /inference="alignment:Splign:2.1.0"
     exon            683..792
                     /gene="tp53"
                     /gene_synonym="lfs1; p53; Trp248; trp53; Xp53; Xrel3"
                     /inference="alignment:Splign:2.1.0"
     exon            793..914
                     /gene="tp53"
                     /gene_synonym="lfs1; p53; Trp248; trp53; Xp53; Xrel3"
                     /inference="alignment:Splign:2.1.0"
     exon            915..1000
                     /gene="tp53"
                     /gene_synonym="lfs1; p53; Trp248; trp53; Xp53; Xrel3"
                     /inference="alignment:Splign:2.1.0"
     exon            1001..1083
                     /gene="tp53"
                     /gene_synonym="lfs1; p53; Trp248; trp53; Xp53; Xrel3"
                     /inference="alignment:Splign:2.1.0"
     exon            1084..2351
                     /gene="tp53"
                     /gene_synonym="lfs1; p53; Trp248; trp53; Xp53; Xrel3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

gccgagaggaacggaccggatagaaacagagcgaccgattcttgttccgttaccgacactttccggcctgtgatctggttctgccatggaaccttcttctgagaccggcatggagccgcccctcagccaggagaccttcgaggatttgtggagcctgttgccggaccccctacagaccgggacaggtcagatggaaaactttgcggagttttcagagtaccccctggcgccagacatgacggttctgcaggaagggcttatgggtaataccgtgcccaccgtgacttcgtctgctgtcccctcaactgaggattacgcagggagctacgggctcaaattggagttccaacagaatggaaccgcaaagtctgttacctgcacatactccaccgacctcaacaagctcttctgccaattggccaagacctgccctttgctggtccgtgtggagagacccccgccgctcggctccattctccgggctacggccgtgtacaagaaatccgagcacgtggccgaggtggtcaagaggtgcccccaccatgagcgcagcgtggagccaggggatgaccctgcccctcccagtcacctgatgcgcgtggagggaaattcaaaggcttattatatggaggatgttggtaccgggcgccatagtgtctgtgtgccctatgagggccctcaggtcggaaccgaatgtaccaccgttctgtacaactatatgtgtaacagctcgtgtatgggtgggatgaaccgccggcccattctcactattatcaccctggagtccccagaggggctgctgcttggccgccgctgctttgaggttcgtgtgtgcgcctgccccgggagggatcgtcgcacagaagaagataattgcacaaagaaacggggcctgaaacccaacgggaagagagagctttctcacccaccatccagtgaccctccacttcccaagaagcgccttgttgaggaggatgatgaagagaccttcaccttgctgattaaggggcggagccgctatgagatgataaagaaactgaatgacgcacttgaattacaagagagcctcgaccagcagaaactgtccataaagtgccgcaagtgccgggacgagatcaaacccaagaaagggaagaagctgctggtgaaagatgagctgcaggactccgagtgagaccccgacgggagccagcacttggggggcatcggtggccggttctccgacttttgttttttttgttttgttttttttttaagctctgtccctccttttagctagtttagagggtccgcattgcccttggggggcccgctagttctatatggcacccaatattatccagtcattatgtgtttgggggctcaattacactgtttactctgtatcattgtaagagatgggggtacacccccccaccctgataatgcatttaaggaaaatgaatgtcatattgttgtggcccacgaacaaagtaccaaggtccccctggcccgcccagtctgtggttccagtgcattatggggcactgggtcaggctgtgtgggtcacccaatcagtgaggtggcaccccacttgggtaaagggagggcctctactcctgccaacctgttagtcattgactcctgtaaggaggagctaatgcagtgggggaggggcttaaggacaggcaaaatagttccctttccattggccaaagtgatggtgttggcccttactggggctgaatcccataatgcatctgtagggctcgggacggcccagtgtacgcatcagagggtggagcttcctgcagattgagttgaattcccccttgagtggggaatgtattggagtgggataggccccgcccatccagggttctgctgactgccaccttattatgtaaccctgtgggtgagggtgtgaatggtatgtgcccagtgtgggagggatataactgccactcctacccccccatacagactctcctggcatgccagcatggtgggcactgtatgggttcattgctgctccggtgtagtggcacctatgcctctgggggtgctagagagctcagggagtttcccaggcaggggcaataagaggcccggggggtaagatttaggctctgaagggcagttatatcgacatttcatggagattagcgccacatttcctcccttcagcgccaaatgggttatgggcatcaatgggttatgggcatcattattcggttgctggggctcccccagatctgcccctgtctccccccccaaatgtgcccctgtctccccataaccttcctttttactaacactcactgccaatgaattttgtatcttctttttttaataaaaaaaatccagtaatcaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa

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