GGRNA | NR_037873.1

LOCUS       NR_037873               5070 bp    RNA     linear   PRI 16-JUL-2013
DEFINITION  Homo sapiens zinc fingers and homeoboxes 1 (ZHX1), transcript
            variant 3, non-coding RNA.
ACCESSION   NR_037873
VERSION     NR_037873.1  GI:323510647
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5070)
  AUTHORS   Bird,L.E., Ren,J., Nettleship,J.E., Folkers,G.E., Owens,R.J. and
            Stammers,D.K.
  TITLE     Novel structural features in two ZHX homeodomains derived from a
            systematic study of single and multiple domains
  JOURNAL   BMC Struct. Biol. 10, 13 (2010)
   PUBMED   20509910
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5070)
  AUTHORS   Wienk,H., Lammers,I., Hotze,A., Wu,J., Wechselberger,R.W.,
            Owens,R., Stammers,D.K., Stuart,D., Kaptein,R. and Folkers,G.E.
  TITLE     The tandem zinc-finger region of human ZHX adopts a novel C2H2 zinc
            finger structure with a C-terminal extension
  JOURNAL   Biochemistry 48 (21), 4431-4439 (2009)
   PUBMED   19348505
  REMARK    GeneRIF: structure of the tandem zinc-finger region of human ZHX1
REFERENCE   3  (bases 1 to 5070)
  AUTHORS   Kim,S.H., Park,J., Choi,M.C., Kim,H.P., Park,J.H., Jung,Y.,
            Lee,J.H., Oh,D.Y., Im,S.A., Bang,Y.J. and Kim,T.Y.
  TITLE     Zinc-fingers and homeoboxes 1 (ZHX1) binds DNA methyltransferase
            (DNMT) 3B to enhance DNMT3B-mediated transcriptional repression
  JOURNAL   Biochem. Biophys. Res. Commun. 355 (2), 318-323 (2007)
   PUBMED   17303076
  REMARK    GeneRIF: ZHX1 enhanced the transcriptional repression mediated by
            DNMT3B when DNMT3B is directly targeted to DNA. These results
            showed for the first the direct linkage between DNMT and
            zinc-fingers homeoboxes protein, leading to enhanced gene silencing
            by DNMT3B
REFERENCE   4  (bases 1 to 5070)
  AUTHORS   Ogata-Kawata,H., Yamada,K., Uesaka-Yoshino,M., Kagawa,N. and
            Miyamoto,K.
  TITLE     BS69, a corepressor interacting with ZHX1, is a bifunctional
            transcription factor
  JOURNAL   Front. Biosci. 12, 1911-1926 (2007)
   PUBMED   17127430
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5070)
  AUTHORS   Liu,G., Clement,L.C., Kanwar,Y.S., Avila-Casado,C. and Chugh,S.S.
  TITLE     ZHX proteins regulate podocyte gene expression during the
            development of nephrotic syndrome
  JOURNAL   J. Biol. Chem. 281 (51), 39681-39692 (2006)
   PUBMED   17056598
  REMARK    GeneRIF: ZHX proteins 1, 2 and 3 are major transcriptional
            mediators of podocyte disease
            Erratum:[J Biol Chem. 2007 Apr 27;282(17):13140]
REFERENCE   6  (bases 1 to 5070)
  AUTHORS   Yamada,K., Kawata,H., Shou,Z., Hirano,S., Mizutani,T., Yazawa,T.,
            Sekiguchi,T., Yoshino,M., Kajitani,T. and Miyamoto,K.
  TITLE     Analysis of zinc-fingers and homeoboxes (ZHX)-1-interacting
            proteins: molecular cloning and characterization of a member of the
            ZHX family, ZHX3
  JOURNAL   Biochem. J. 373 (PT 1), 167-178 (2003)
   PUBMED   12659632
  REMARK    GeneRIF: a search of ZHX1-interacting proteins using a yeast
            two-hybrid system
REFERENCE   7  (bases 1 to 5070)
  AUTHORS   Yamada,K., Kawata,H., Matsuura,K., Shou,Z., Hirano,S., Mizutani,T.,
            Yazawa,T., Yoshino,M., Sekiguchi,T., Kajitani,T. and Miyamoto,K.
  TITLE     Functional analysis and the molecular dissection of zinc-fingers
            and homeoboxes 1 (ZHX1)
  JOURNAL   Biochem. Biophys. Res. Commun. 297 (2), 368-374 (2002)
   PUBMED   12237128
  REMARK    GeneRIF: This study characterized features of ZHX-1 involved in
            nuclear localization, dimerization, and transcriptional activity,
            and mapped these domains.
REFERENCE   8  (bases 1 to 5070)
  AUTHORS   Hirano,S., Yamada,K., Kawata,H., Shou,Z., Mizutani,T., Yazawa,T.,
            Kajitani,T., Sekiguchi,T., Yoshino,M., Shigematsu,Y., Mayumi,M. and
            Miyamoto,K.
  TITLE     Rat zinc-fingers and homeoboxes 1 (ZHX1), a nuclear
            factor-YA-interacting nuclear protein, forms a homodimer
  JOURNAL   Gene 290 (1-2), 107-114 (2002)
   PUBMED   12062805
REFERENCE   9  (bases 1 to 5070)
  AUTHORS   Yamada,K., Osawa,H. and Granner,D.K.
  TITLE     Identification of proteins that interact with NF-YA
  JOURNAL   FEBS Lett. 460 (1), 41-45 (1999)
   PUBMED   10571058
REFERENCE   10 (bases 1 to 5070)
  AUTHORS   Yamada,K., Printz,R.L., Osawa,H. and Granner,D.K.
  TITLE     Human ZHX1: cloning, chromosomal location, and interaction with
            transcription factor NF-Y
  JOURNAL   Biochem. Biophys. Res. Commun. 261 (3), 614-621 (1999)
   PUBMED   10441475
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK289532.1, AF106862.1,
            CA776642.1, BC040481.1 and AK025236.1.
            
            Summary: The members of the zinc fingers and homeoboxes gene family
            are nuclear homodimeric transcriptional repressors that interact
            with the A subunit of nuclear factor-Y (NF-YA) and contain two
            C2H2-type zinc fingers and five homeobox DNA-binding domains. This
            gene encodes member 1 of this gene family. In addition to forming
            homodimers, this protein heterodimerizes with members 2 and 3 of
            the zinc fingers and homeoboxes family. Alternative splicing
            results in multiple transcript variants. Read-through transcription
            also exists between this gene and the downstream chromosome 8 open
            reading frame 76 (C8orf76) gene. [provided by RefSeq, Feb 2011].
            
            Transcript Variant: This variant (3) contains an alternate first
            exon, compared to variant 1. This variant is represented as
            non-coding due to the presence of an upstream ORF that is predicted
            to interfere with translation of the downstream ORF, as found in
            variant 1. Translation of the upstream ORF would render the
            transcript a candidate for nonsense-mediated mRNA decay (NMD).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2342              AK289532.1         1-2342
            2343-3648           AF106862.1         1826-3131
            3649-4103           CA776642.1         140-594
            4104-5024           BC040481.1         3994-4914
            5025-5070           AK025236.1         2584-2629
FEATURES             Location/Qualifiers
     source          1..5070
                     /organism="Homo sapiens"
                     /mol_type="transcribed RNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q24.13"
     gene            1..5070
                     /gene="ZHX1"
                     /note="zinc fingers and homeoboxes 1"
                     /db_xref="GeneID:11244"
                     /db_xref="HGNC:12871"
                     /db_xref="MIM:604764"
     misc_RNA        1..5070
                     /gene="ZHX1"
                     /product="zinc fingers and homeoboxes 1, transcript
                     variant 3"
                     /db_xref="GeneID:11244"
                     /db_xref="HGNC:12871"
                     /db_xref="MIM:604764"
     exon            1..202
                     /gene="ZHX1"
                     /inference="alignment:Splign:1.39.8"
     misc_feature    126..248
                     /gene="ZHX1"
                     /inference="COORDINATES: ab initio prediction:ORF Finder"
                     /note="long (>35aa) upstream ORF has strong Kozak
                     sequence; nonsense-mediated decay (NMD) candidate"
     exon            203..316
                     /gene="ZHX1"
                     /inference="alignment:Splign:1.39.8"
     exon            317..3166
                     /gene="ZHX1"
                     /inference="alignment:Splign:1.39.8"
     variation       532
                     /gene="ZHX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:16898197"
     misc_feature    542..3163
                     /gene="ZHX1"
                     /inference="COORDINATES:
                     alignment:Blast2seq::RefSeq|NM_007222.4"
                     /note="primary ORF"
     exon            3167..5037
                     /gene="ZHX1"
                     /inference="alignment:Splign:1.39.8"
     variation       3649..3650
                     /gene="ZHX1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:1966863"
     polyA_signal    4720..4725
                     /gene="ZHX1"
     variation       4741
                     /gene="ZHX1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:1869248"
     polyA_site      4744
                     /gene="ZHX1"
     polyA_signal    5007..5012
                     /gene="ZHX1"
     polyA_site      5037
                     /gene="ZHX1"
ORIGIN

aaaaaatcagacttccacttgaagcaattgcatcttttaggattaatgtggctcagcggagctctgctgtgcttttaggattactgtggctcagcggagctctgcacaaagggtccgcgactgggatgggggtggggagtgaacgtcaaggggcccaggagcgctcgagcgtccaaggcccggcgtgtggagcagctggagggagaagacagactgctgctttggacctgttggtaatgatggcctgagctaaacatctaactagaagggatacccttccatttcaaagaacagaatgctaaggaagctgtggcaagtgattggagttgtgcttcaaaaatttcagaaattcagcagtattttatctgccaacaataagctctttacttgattgcaccatgagaaagctgctaatgagacttgttgagcacaaaaatggacttgaagaaccaaaagccattgttttcaaatgaagaacactgaacagttttaagcctcgatgctttttaatcaccactgagcttttcctcataacatcagaatggcaagcaggcgaaaatcaacaacaccttgcatggtccttgccagtgaacaagatccagaccttgagttgatatcagatttggatgaaggtcctcctgtgcttacacctgtagaaaacaccagagcagagagtatctcaagtgatgaagaggttcatgaatctgtggattcagacaatcagcaaaataaaaaagttgaaggtggatatgaatgtaaatattgtacttttcaaactccagatctaaatatgtttacttttcatgtggattcggaacatcccaatgtagtgctaaattcatcctatgtttgtgtcgaatgcaattttcttaccaaaaggtatgatgcactttctgagcataatctgaaatatcacccaggagaagagaattttaagttgactatggtgaaacgtaataaccagacaatctttgaacaaacaataaatgatctgacttttgatggtagttttgttaaagaggagaatgcagagcaagcagaatctacagaagtttcttcttcgggaatatctatcagtaaaactcctatcatgaaaatgatgaaaaataaagtggaaaataaacggattgcagttcatcataactcagttgaggacgttcctgaagagaaagagaatgaaatcaaaccagaccgtgaagaaattgtagaaaatccaagttcttcagcttctgaatctaatacaagtacttccattgtaaacagaatacatccaagtactgccagcacggtagtgacaccagcagcagttcttcctggattggcacaggtgataactgctgtatctgctcagcagaattctaatttgattcccaaagtcttaatccctgttaatagcattcccacctacaatgctgcattggataacaatccccttttacttaacacctacaacaagttcccttacccaacaatgtcagaaattacagttctttctgctcaagcaaaatatacagaggaacagatcaagatatggttttcagcccaacgtttaaaacatggtgttagttggactcccgaggaagtagaggaggcaagaaggaaacaattcaatggaacagtgcatactgtacctcagaccataactgttattcctacacacatttccacagggagtaatggtttaccatctattttacagacatgccaaatagttggtcagcctggtctggtccttactcaagtggctggaacaaacaccttgccagttacagcacctatagccttgacagtggcaggcgttccaagtcaaaataatatacagaaaagtcaggtacctgctgctcagcctactgcagaaacaaagccagcaacagcagcagttccaacttctcaaagtgtcaaacatgaaactgcattggtaaaccctgattcatttggcattcgggcaaaaaagacaaaagagcaactggcagaattaaaagttagctaccttaaaaatcagtttccccatgattcagaaattatcagacttatgaaaataacaggcctgacgaaaggagagattaaaaaatggtttagtgacacaaggtacaaccagagaaattcaaagagtaatcagtgcttacatctcaacaatgattcctctaccaccattattatagactccagtgatgaaaccacggaatccccaactgttggtactgcacagcctaagcaatcctggaatccttttcctgactttactccccaaaagtttaaagagaaaactgcagagcagcttcgtgtccttcaggcaagttttctcaacagctctgtacttacagatgaagaattaaataggttaagggcacaaaccaaacttaccagaagagaaatcgatgcttggtttacagagaagaagaaatcaaaagctttaaaggaagagaaaatggaaatagatgaaagtaatgcaggtagttccaaagaagaagctggagaaacttctcctgcagatgaatctggtgcacctaagtcagggagtacaggcaagatatgtaaaaaaacacctgagcagctgcacatgcttaagagtgcatttgtccggacacagtggccatcaccagaagagtatgacaagttggccaaagaaagcgggcttgctagaacagacatagttagttggtttggggacacccgttatgcttggaagaatggaaacttgaaatggtactactactatcagagcgccaattcaagtagtatgaatggtctgtcttcccttaggaaaagagggagagggagacccaaaggacggggaagaggaagaccgcgtgggcggcctagaggaagcaaaagaattaacaactgggacaggggaccatcactcataaaatttaaaactggaactgcaatacttaaggattattacctgaagcacaagtttcttaatgagcaagaccttgatgaacttgttaacaaatcacatatgggctatgagcaggtcagagagtggtttgcagaaagacagagaagatcagaattaggtatagaattatttgaggaaaatgaggaggaagatgaagttattgatgaccaggaagaggatgaagaagaaacagatgatagtgacacttgggaacctccacgacatgtgaaacggaagctgtctaaatcagatgactgaaatctgcctaaaacgttgaaggagaatcaattcttcaactcaagatgtctgatttactgtgaatttgcccaatctttgatgacattgaaaacgttttggggcatacacactcaaaaagcaggatccaatacccaaaagaaatggaacttaatgttgtgccaaagttaaactactgcagttggtggaagttctgcaatgtaaatagaacactaattaaaaaacaacttgtaaaaatgcaatttaaattttaatacagtacatttttcttctaatatgatggagacattctgaatcttagactttctgagggggtttaatgaccactagagcttgtcctcatattcagtccagtttaatactgtatgtctagtaagatgggctatatattgcctctattctttgagatgtgattaagcttagaactttgaccaaaaattttacagtaaaaattgttagaaatgggtaaaaaaaaaaaaaaaaaaaaaaccctgatttattactatgtcttatttatcagaccctgcactaagattaaaagttgtgcatgggcttatacaatttcaaatgtaaaaacagcctatttatatatgttgaaacaataagattttatggtttcactggcccttaataattggatccttcattaaacacatccatgaataccactgtttctactgttacttgttccattagaagctgatttgctttttattaaactgcaggaaattaattctgaagaaggaaaagaaactgacatggtaatttggatagggtgaagctttgaaataaatactgcaccaaaaatgtgaaaaagaatcacgtagtaaatgtatacttagtgttttcttacaatcgtggaaatcagaaatgtttatacaggtgtcagatcagaatttttaagagttatctttcagtgaaattttataacagtttcagtgaatagagaaaaaattctgaactgatcataatgagttaaaagttagcttttcacttatgaatcatgggagtgttaactgttaactcttgccgtatcaggagactgaaagttcatactaatttacaaactttgtaaagactggtgctgttcattcatattgggaagaaccctttcttttgtgaccataggaccatttttcaaaatgcgctttcttcgtagaagaaatgttcagtttaattagctttggattttaacatgtttttctgaatgaccagatgtaggcttagccagtttattttctctaatttaatggataataaatattaagctcttggttaaatgtttttcagccattgaaaatgttatgaaaaagccttgaatatgcatgctgctttcatttttataaactttttattttttaactatagctttattagtaattccaaaatgctgcaatgtagctgatttcctcactcagacagctggctttgtgggtggcttttttcatactactgttaacttttttaaaaaagaagcaatgtaaagaccgtaatgcactaagctttttttttttcttttacacgtttaaaaacttcttaaagcactctgtaatataatgattaaattgctcccttttataaacattgctaatgtggtctgagttttgtttgacaataattttaatgttctcaaaatttgaaatgtcaagtattagaaatgaagcctttgaatatagttgtttcccttgcaatatgttaactctgtgtagctgtatataactattaatttccctcatctcttttataggcctgataaaactcttctctgacgtttgctagcttttaaatatatttatttgacagagcaaaagaaccctcttctggttgattgtgaccttgaatacaaaataaaagtagtgattagtagtttacagtgaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa

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