LOCUS       NR_026893               5173 bp    RNA     linear   PRI 16-JUL-2013
DEFINITION  Homo sapiens POU class 6 homeobox 1 (POU6F1), transcript variant 2,
            non-coding RNA.
ACCESSION   NR_026893
VERSION     NR_026893.1  GI:223890226
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5173)
  AUTHORS   Suzuki,N., Yoshioka,N., Uekawa,A., Matsumura,N., Tozawa,A.,
            Koike,J., Konishi,I., Kiguchi,K. and Ishizuka,B.
  TITLE     Transcription factor POU6F1 is important for proliferation of clear
            cell adenocarcinoma of the ovary and is a potential new molecular
            target
  JOURNAL   Int. J. Gynecol. Cancer 20 (2), 212-219 (2010)
   PUBMED   20134265
  REMARK    GeneRIF: POU6F1 siRNA dose-dependently suppressed the proliferation
            of clear cell adenocarcinoma cell lines.
REFERENCE   2  (bases 1 to 5173)
  AUTHORS   Yoshioka,N., Suzuki,N., Uekawa,A., Kiguchi,K. and Ishizuka,B.
  TITLE     POU6F1 is the transcription factor that might be involved in cell
            proliferation of clear cell adenocarcinoma of the ovary
  JOURNAL   Hum. Cell 22 (4), 94-100 (2009)
   PUBMED   19874398
  REMARK    GeneRIF: is the transcription factor that might be involved in cell
            proliferation of clear cell adenocarcinoma of the ovary.
REFERENCE   3  (bases 1 to 5173)
  AUTHORS   Pereira,J.H. and Kim,S.H.
  TITLE     Structure of human Brn-5 transcription factor in complex with CRH
            gene promoter
  JOURNAL   J. Struct. Biol. 167 (2), 159-165 (2009)
   PUBMED   19450691
  REMARK    GeneRIF: The crystal structure of human Brn-5 transcription factor
            in complex with corticotropin-releasing hormone gene promoter
            reveals an unexpected recognition mode of the protein to its
            cognate DNA
REFERENCE   4  (bases 1 to 5173)
  AUTHORS   Pereira,J.H., Ha,S.C. and Kim,S.H.
  TITLE     Crystallization and preliminary X-ray analysis of human Brn-5
            transcription factor in complex with DNA
  JOURNAL   Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 64 (PT 3),
            175-178 (2008)
   PUBMED   18323601
  REMARK    GeneRIF: Crystallization and preliminary X-ray analysis
REFERENCE   5  (bases 1 to 5173)
  AUTHORS   Abdel-Rahman,B., Fiddler,M., Rappolee,D. and Pergament,E.
  TITLE     Expression of transcription regulating genes in human
            preimplantation embryos
  JOURNAL   Hum. Reprod. 10 (10), 2787-2792 (1995)
   PUBMED   8567814
REFERENCE   6  (bases 1 to 5173)
  AUTHORS   Wey,E., Lyons,G.E. and Schafer,B.W.
  TITLE     A human POU domain gene, mPOU, is expressed in developing brain and
            specific adult tissues
  JOURNAL   Eur. J. Biochem. 220 (3), 753-762 (1994)
   PUBMED   7908264
REFERENCE   7  (bases 1 to 5173)
  AUTHORS   Messier,H., Brickner,H., Gaikwad,J. and Fotedar,A.
  TITLE     A novel POU domain protein which binds to the T-cell receptor beta
            enhancer
  JOURNAL   Mol. Cell. Biol. 13 (9), 5450-5460 (1993)
   PUBMED   8102789
REFERENCE   8  (bases 1 to 5173)
  AUTHORS   Takeda,J., Seino,S. and Bell,G.I.
  TITLE     Human Oct3 gene family: cDNA sequences, alternative splicing, gene
            organization, chromosomal location, and expression at low levels in
            adult tissues
  JOURNAL   Nucleic Acids Res. 20 (17), 4613-4620 (1992)
   PUBMED   1408763
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AI417271.1, AK095191.1, AL832881.1, BC051326.1, DA026332.1,
            DA084199.1, AC139768.14, BM703234.1, CK002954.1 and AW445212.1.
            
            Transcript Variant: This variant (2) contains additional exons at
            the 5' end, compared to variant 1. This variant is represented as
            non-coding due to the presence of an upstream ORF that is predicted
            to interfere with translation of the longest ORF; translation of
            the upstream ORF renders the transcript a candidate for
            nonsense-mediated mRNA decay (NMD).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-321               AI417271.1         63-383
            322-1475            AK095191.1         322-1475
            1476-2369           AL832881.1         1018-1911
            2370-2932           BC051326.1         1715-2277
            2933-3222           DA026332.1         279-568
            3223-3515           DA084199.1         230-522
            3516-4109           AC139768.14        57379-57972
            4110-4576           BM703234.1         1-467
            4577-4818           CK002954.1         249-490
            4819-5173           AW445212.1         1-355               c
FEATURES             Location/Qualifiers
     source          1..5173
                     /organism="Homo sapiens"
                     /mol_type="transcribed RNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q13.13"
     gene            1..5173
                     /gene="POU6F1"
                     /gene_synonym="BRN5; MPOU; TCFB1"
                     /note="POU class 6 homeobox 1"
                     /db_xref="GeneID:5463"
                     /db_xref="HGNC:9224"
     misc_RNA        1..5173
                     /gene="POU6F1"
                     /gene_synonym="BRN5; MPOU; TCFB1"
                     /product="POU class 6 homeobox 1, transcript variant 2"
                     /db_xref="GeneID:5463"
                     /db_xref="HGNC:9224"
     exon            1..52
                     /gene="POU6F1"
                     /gene_synonym="BRN5; MPOU; TCFB1"
                     /inference="alignment:Splign:1.39.8"
     exon            53..147
                     /gene="POU6F1"
                     /gene_synonym="BRN5; MPOU; TCFB1"
                     /inference="alignment:Splign:1.39.8"
     misc_feature    100..846
                     /gene="POU6F1"
                     /gene_synonym="BRN5; MPOU; TCFB1"
                     /inference="COORDINATES: ab initio prediction:ORF Finder"
                     /note="long (>35aa) upstream ORF has strong Kozak
                     sequence; nonsense-mediated decay (NMD) candidate"
     exon            148..343
                     /gene="POU6F1"
                     /gene_synonym="BRN5; MPOU; TCFB1"
                     /inference="alignment:Splign:1.39.8"
     exon            344..465
                     /gene="POU6F1"
                     /gene_synonym="BRN5; MPOU; TCFB1"
                     /inference="alignment:Splign:1.39.8"
     variation       379
                     /gene="POU6F1"
                     /gene_synonym="BRN5; MPOU; TCFB1"
                     /replace="a"
                     /replace="c"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:4077093"
     exon            466..602
                     /gene="POU6F1"
                     /gene_synonym="BRN5; MPOU; TCFB1"
                     /inference="alignment:Splign:1.39.8"
     exon            603..856
                     /gene="POU6F1"
                     /gene_synonym="BRN5; MPOU; TCFB1"
                     /inference="alignment:Splign:1.39.8"
     exon            857..985
                     /gene="POU6F1"
                     /gene_synonym="BRN5; MPOU; TCFB1"
                     /inference="alignment:Splign:1.39.8"
     misc_feature    941..1846
                     /gene="POU6F1"
                     /gene_synonym="BRN5; MPOU; TCFB1"
                     /inference="COORDINATES:
                     alignment:Blast2seq::RefSeq|NM_002702.3"
                     /note="primary ORF"
     exon            986..1189
                     /gene="POU6F1"
                     /gene_synonym="BRN5; MPOU; TCFB1"
                     /inference="alignment:Splign:1.39.8"
     exon            1190..1331
                     /gene="POU6F1"
                     /gene_synonym="BRN5; MPOU; TCFB1"
                     /inference="alignment:Splign:1.39.8"
     exon            1332..1500
                     /gene="POU6F1"
                     /gene_synonym="BRN5; MPOU; TCFB1"
                     /inference="alignment:Splign:1.39.8"
     exon            1501..5157
                     /gene="POU6F1"
                     /gene_synonym="BRN5; MPOU; TCFB1"
                     /inference="alignment:Splign:1.39.8"
     variation       1729
                     /gene="POU6F1"
                     /gene_synonym="BRN5; MPOU; TCFB1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:2228250"
     variation       1997
                     /gene="POU6F1"
                     /gene_synonym="BRN5; MPOU; TCFB1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1126902"
     variation       2370
                     /gene="POU6F1"
                     /gene_synonym="BRN5; MPOU; TCFB1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:3490"
     variation       2375
                     /gene="POU6F1"
                     /gene_synonym="BRN5; MPOU; TCFB1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1126904"
     variation       2435
                     /gene="POU6F1"
                     /gene_synonym="BRN5; MPOU; TCFB1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1126905"
     polyA_signal    2847..2852
                     /gene="POU6F1"
                     /gene_synonym="BRN5; MPOU; TCFB1"
     polyA_signal    2892..2897
                     /gene="POU6F1"
                     /gene_synonym="BRN5; MPOU; TCFB1"
     polyA_site      2932
                     /gene="POU6F1"
                     /gene_synonym="BRN5; MPOU; TCFB1"
     polyA_signal    5133..5138
                     /gene="POU6F1"
                     /gene_synonym="BRN5; MPOU; TCFB1"
     polyA_site      5157
                     /gene="POU6F1"
                     /gene_synonym="BRN5; MPOU; TCFB1"
ORIGIN      

aatcggtggccgccagacacccgcggcgaaggcggctcgggctcgggctccggatgtgctaggtgtgggccggcccccacccgaccctgacaagtgaccatggatcctggagccgggtcagagacatctctgactgtcaatgagcaggtcatcgtgatgtcaggtcatgagaccatccgagtgctggaagtcggagtggatgcccaactccctgctgaggaagagagcaaaggactggagggtgtggccgccgagggctcccagagcggagaccctgctgaagccagtcaagctgctggtgaagctgggccagacaacctgggctcctctgcagaggcaactgtgaagtcacccccggggatccctccgagccctgcccctgccattgccaccttcagccaagccccaagccagcctcaggcatcgcagaccctgacgccactggctgtacaagctgccccccagtattgcaggtcaagtggctggtcagcaggggctggccgtgtggacaattcctacagcaactgtggctgccctcccaggactgaccgctgcttctcctacggggggagtgttcaagccacctttagccggtctccaagcagctgctgtgctgaacaccgctcttccggcaccggtacaagctgccgcaccagtacaggcctcctcgacggcccaaccccggccaccagcccagccccagacgctgttccagacccagccgctgctgcagaccacacctgccatcctcccgcagcccactgctgccaccgctgctgcccctacccccaagccagtggacacccccccacagatcaccgtccagcctgcaggcttcgcatttagcccaggaatcatcagtgctgcttccctcgggggacagacccagatcctggggtccctcactacagctccagtcattaccagcgccattcccagcatgccagggatcagcagtcagatcctcaccaatgctcagggacaggttattggaacccttccatgggtagtgaactcagctagtgtggcggccccagcaccagcccaaagcctgcaggtccaggccgtgaccccccagctgttgttgaacgcccagggccaggtgattgcgaccctggctagcagccccctgcctccacctgtggctgtccggaagccaagcacacctgagtcccctgctaagagtgaggtgcagcccatccagcccacaccaaccgtgccccagcctgctgtggtcattgccagcccagctccagccgccaagccatctgcctctgctcctatcccaattacctgctcagagacccccaccgtcagccagttggtgtccaagccacatactccaagtctggatgaggatgggatcaacttagaagagatccgggagtttgccaagaactttaagatccggcggctctcgctgggccttacacagacccaggtgggtcaggctctgactgcaacggaaggtccagcctacagccagtcagccatctgccggttcgagaagctagacatcacacccaagagtgcccagaagctaaagccggtgctggaaaagtggctaaacgaagctgaactgcggaaccaggaaggccagcagaacctgatggagtttgtgggaggcgagccctccaagaaacgcaaacgccgcacctccttcaccccccaggccatagaggctctcaatgcctattttgagaagaacccactgcccacaggccaggagatcactgaaattgctaaggagctcaactacgaccgtgaggtagtgcgggtctggttctgcaatcggcgccagacgctcaagaacaccagcaagctgaacgtctttcagatcccttagggctcagcccctggccctgtgttctagcactttgtccatttcccgtggcatccggctgcagccactgccatgacagcacctgtcattttgccacgtgcagctgtgctcaccccaggtcatcagactccaccgtgtgcatgtgcatcaatgtccctcttttctcccacacatctcacatcatggggaggccagagggggccacacgagagctccaggctctgggctggtcactccgaagaagaggatttgtgacgtcacttagagaagcaccttgctagcatggtttctgaagggtgaattctggtggggaaccagaaactccctgtctttggggcagggctaaagcagctcctaaggaccactggccattagctcttgcttttgatggcattctctttccaccttgtcttctcctttgctcctctgtgttagtgtggcaggtatgacaactcatccagtggaaacacagcctcacactgcccttccgccccccacactttgcctgcaggtgcaccgaaaggacctgggagataaaattcaaaaaagtgtgatgtgctgctcagaaggtcagactccatgtctgccttgacctcaaggtcagaaggttcccaaacccctggggctggaacatgggatctcctcttccacctcttcctggttcctttgcggggaaaattgcactaaaacagaaccttttcttaatccatgttggaaggaagcaacagtgaactctacctgttctggagttctcctgggtctgcagaaggttgggaatttagaaaataaggctgttctttcatattttaatttaatctctgtcaatggccatccctcccacaaaaaaacgtgggttaagagaacttgcagactggatatgcaagcaaacgggcaactctggagaaaaataaggaaaggaatgctgactttctctttctttctcttgtccccacacccattcccaacccaatactggggccttctcaaaaggagcaaattaaacaataaaccagacagcaaggccctgggggaaaggacaacatcctgaaataaatgatggagcccaggaaggtctcttgtggaagttgacttaactctaattttctttgtaactttaagccttggatacgggaggagaaatctcattttgtcgagtctcagaccatgtctgtgtgtaagcaatccccacagtgtcctctgagccaaggacacccccagatcagattgagttttgcttctagacggggtagctatggtaccttgggggttagctctcatccaagctgttaagtgagtttccagcctcactgtggctggaaagcccctaaaattcagtatgtaactccaggaagtcaggagagaactgagatttgcctagatgaccacaggcttgcggtgtagattatccctaaagggccccaagtcacgggggtcaaccacccctgtcttcagtactcttatccttacagaggctggtctctaacagctgcctccagtggacctcccatgatccaccctgagggaaggaccgtcagctggggacacatcaccacctctgtcagtcactggtgcagagccacctcctagcctagcttcctctggtgtcctgtttcctttcccacttactgttggtgcctcccaggccctgcagtgccagcgtggccaccctcttggtagcctggccagtaagaggaggacagttgtgtgctgaattagcacacgcacgtgcagcgcgcacagacgcgcgcacacacacacacatacacgctctgctgcatttggacaaaccatgcctgccagagtgtagcagaggtgaggaagcaggtgggcagcttgcctgacccagcttttcaggagagcgtgtctccaacagagagtctccacactctagttcagggttatcgacctgcctcaatgagatgacagactcatttgggaggggtgttgcaaacaagttttcagtgagaatagttaagttccagagcttgtaaaggattcagtgactgacacttcagtaaattaggccaggcacattggcttatgcctgtaattccaacactttggaaggccgaggtgggcggatcatttgaggtctggagttcgagaccagcctgaccaacatggtgaaaccccgtctctactaaaaatacaaaaattagccaggtgtggtagtgcacatctgtaatcccagctacttgggaggtggaggcaggagaattgcttgaaccctggaggttgcaatgagctgagatcacactacttcactccagcctgggtgacagagcaagactcggtctcaaacaaacaaaaacttatggcgatgcaggttttcatgctcagacgcttgcattcaggtatgctttcttttttgagagagacaaatgggtcacagctggcaccctgggaatagcacataatccagggtgtgtctgtggtggtggacgtgcaggggaacaccatctgtcctgtgtcatgatgggaaaacaatcatgaaccactggtctaaattaggcctggccatgctttctcagcccctccctcatttaaatttgtcttcccaaagctgagctaaaactaaaccatttctcctctgctggaatgatggattggtcattcagaggaacaataccaggggtgggaggtttgcaggctgagttccccaggcatgggggtgcagggtgtccctgaggtttacccaaagcacagctcgctggcctgtgacctctgcccttcctcccacagtgtaagaccccccaggaagcagctggggcctgaacctctcacctaggaggtaggtttattttattttttgttagcatcaggctctgaaggagttggtatacattttgttttgaaaacatcttctggacttacaccagagcttagtgtcgtctttactatggaaagagaggagaatggacagaaatggtttaactgtgtggagttttgtttgttttgttttaaatggaagaaagaccaaaactttcctggtggatcagctagggcctttgaccctgcattaccacggcattttatccaggtgaagtccagggaaagaactcagccaaatggactaaggaacacacgagtttggaatgcgagactctgacatttttgtgttcttggaaatccaattaccttcccatgcccagatttccttcctgcctcttggaccaggctctggcactgaggttctcactgttcccaacacagacaaagcttcctgagggctggaggggcagcaaggggagaggagaatggggaagaagcgcttgatgtagttgtgtggaataaacagtattttttcttttgtaaaaaaaaaaaaaaaaa

//

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:5463 -> Molecular function: GO:0003700 [sequence-specific DNA binding transcription factor activity] evidence: IEA
            GeneID:5463 -> Molecular function: GO:0043565 [sequence-specific DNA binding] evidence: IEA
            GeneID:5463 -> Biological process: GO:0006351 [transcription, DNA-dependent] evidence: IEA
            GeneID:5463 -> Biological process: GO:0007420 [brain development] evidence: TAS
            GeneID:5463 -> Biological process: GO:0007507 [heart development] evidence: TAS
            GeneID:5463 -> Biological process: GO:0007517 [muscle organ development] evidence: TAS
            GeneID:5463 -> Cellular component: GO:0031965 [nuclear membrane] evidence: IDA
            GeneID:5463 -> Cellular component: GO:0043231 [intracellular membrane-bounded organelle] evidence: IDA