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2024-04-19 09:37:32, GGRNA : RefSeq release 60 (20130726)
LOCUS NR_026571 4386 bp RNA linear PRI 16-JUL-2013
DEFINITION Homo sapiens NADPH oxidase 4 (NOX4), transcript variant 4,
non-coding RNA.
ACCESSION NR_026571
VERSION NR_026571.1 GI:219842349
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4386)
AUTHORS Koziel,R., Pircher,H., Kratochwil,M., Lener,B., Hermann,M.,
Dencher,N.A. and Jansen-Durr,P.
TITLE Mitochondrial respiratory chain complex I is inactivated by NADPH
oxidase Nox4
JOURNAL Biochem. J. 452 (2), 231-239 (2013)
PUBMED 23514110
REMARK GeneRIF: Nox4 specifically inhibits the activity of mitochondrial
electron transport chain complex I, decreasing the concentration of
complex I subunits and mitochondrial function by a new pathway.
REFERENCE 2 (bases 1 to 4386)
AUTHORS Matsushima,S., Kuroda,J., Ago,T., Zhai,P., Ikeda,Y., Oka,S.,
Fong,G.H., Tian,R. and Sadoshima,J.
TITLE Broad suppression of NADPH oxidase activity exacerbates
ischemia/reperfusion injury through inadvertent downregulation of
hypoxia-inducible factor-1alpha and upregulation of peroxisome
proliferator-activated receptor-alpha
JOURNAL Circ. Res. 112 (8), 1135-1149 (2013)
PUBMED 23476056
REMARK GeneRIF: Nox4 protects the heart from ischemia/reperfusion injury
by regulating hypoxia-inducible factor-1alpha and peroxisome
proliferator-activated receptor-alpha.
REFERENCE 3 (bases 1 to 4386)
AUTHORS Anilkumar,N., Jose,G.S., Sawyer,I., Santos,C.X., Sand,C.,
Brewer,A.C., Warren,D. and Shah,A.M.
TITLE A 28-kDa splice variant of NADPH oxidase-4 is nuclear-localized and
involved in redox signaling in vascular cells
JOURNAL Arterioscler. Thromb. Vasc. Biol. 33 (4), E104-E112 (2013)
PUBMED 23393389
REMARK GeneRIF: Nox4D is a nuclear-localized and functionally active
splice variant of Nox4 that may have important pathophysiologic
effects through modulation of nuclear signaling and DNA damage in
vascular cells.
REFERENCE 4 (bases 1 to 4386)
AUTHORS Comuzzie,A.G., Cole,S.A., Laston,S.L., Voruganti,V.S., Haack,K.,
Gibbs,R.A. and Butte,N.F.
TITLE Novel genetic loci identified for the pathophysiology of childhood
obesity in the Hispanic population
JOURNAL PLoS ONE 7 (12), E51954 (2012)
PUBMED 23251661
REFERENCE 5 (bases 1 to 4386)
AUTHORS Chang,G., Chen,L., Lin,H.M., Lin,Y. and Maranchie,J.K.
TITLE Nox4 inhibition enhances the cytotoxicity of cisplatin in human
renal cancer cells
JOURNAL J. Exp. Ther. Oncol. 10 (1), 9-18 (2012)
PUBMED 22946340
REMARK GeneRIF: Nox4 contributes to renal cancer cells chemo-resistance
through modulation of pro-apoptotic and anti-apoptotic signaling,
suggesting that Nox4 inhibition might enhance the efficacy of
conventional cytotoxic drugs against RCC.
REFERENCE 6 (bases 1 to 4386)
AUTHORS Bedard,K. and Krause,K.H.
TITLE The NOX family of ROS-generating NADPH oxidases: physiology and
pathophysiology
JOURNAL Physiol. Rev. 87 (1), 245-313 (2007)
PUBMED 17237347
REMARK Review article
REFERENCE 7 (bases 1 to 4386)
AUTHORS Brar,S.S., Kennedy,T.P., Sturrock,A.B., Huecksteadt,T.P.,
Quinn,M.T., Whorton,A.R. and Hoidal,J.R.
TITLE An NAD(P)H oxidase regulates growth and transcription in melanoma
cells
JOURNAL Am. J. Physiol., Cell Physiol. 282 (6), C1212-C1224 (2002)
PUBMED 11997235
REFERENCE 8 (bases 1 to 4386)
AUTHORS Cheng,G., Cao,Z., Xu,X., van Meir,E.G. and Lambeth,J.D.
TITLE Homologs of gp91phox: cloning and tissue expression of Nox3, Nox4,
and Nox5
JOURNAL Gene 269 (1-2), 131-140 (2001)
PUBMED 11376945
REFERENCE 9 (bases 1 to 4386)
AUTHORS Shiose,A., Kuroda,J., Tsuruya,K., Hirai,M., Hirakata,H., Naito,S.,
Hattori,M., Sakaki,Y. and Sumimoto,H.
TITLE A novel superoxide-producing NAD(P)H oxidase in kidney
JOURNAL J. Biol. Chem. 276 (2), 1417-1423 (2001)
PUBMED 11032835
REFERENCE 10 (bases 1 to 4386)
AUTHORS Geiszt,M., Kopp,J.B., Varnai,P. and Leto,T.L.
TITLE Identification of renox, an NAD(P)H oxidase in kidney
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 97 (14), 8010-8014 (2000)
PUBMED 10869423
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from AP002404.2, AJ704725.1,
BU730205.1, AP001815.4 and AW207163.1.
Summary: This gene encodes a member of the NOX-family of enzymes
that functions as the catalytic subunit the NADPH oxidase complex.
The encoded protein is localized to non-phagocytic cells where it
acts as an oxygen sensor and catalyzes the reduction of molecular
oxygen to various reactive oxygen species (ROS). The ROS generated
by this protein have been implicated in numerous biological
functions including signal transduction, cell differentiation and
tumor cell growth. A pseudogene has been identified on the other
arm of chromosome 11. Alternative splicing results in multiple
transcript variants.[provided by RefSeq, Jan 2009].
Transcript Variant: This variant (4) uses an alternate splice site
in an internal exon, compared to variant 1. This variant is
represented as non-coding because the use of the 5'-most supported
translational start codon, as used in variant 1, renders the
transcript a candidate for nonsense-mediated mRNA decay (NMD).
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-239 AP002404.2 26180-26418 c
240-1972 AJ704725.1 1-1733
1973-2384 BU730205.1 16-427 c
2385-3943 AP001815.4 17607-19165 c
3944-4386 AW207163.1 1-443 c
FEATURES Location/Qualifiers
source 1..4386
/organism="Homo sapiens"
/mol_type="transcribed RNA"
/db_xref="taxon:9606"
/chromosome="11"
/map="11q14.2-q21"
gene 1..4386
/gene="NOX4"
/gene_synonym="KOX; KOX-1; RENOX"
/note="NADPH oxidase 4"
/db_xref="GeneID:50507"
/db_xref="HGNC:7891"
/db_xref="MIM:605261"
misc_RNA 1..4386
/gene="NOX4"
/gene_synonym="KOX; KOX-1; RENOX"
/product="NADPH oxidase 4, transcript variant 4"
/db_xref="GeneID:50507"
/db_xref="HGNC:7891"
/db_xref="MIM:605261"
exon 1..296
/gene="NOX4"
/gene_synonym="KOX; KOX-1; RENOX"
/inference="alignment:Splign:1.39.8"
variation 177
/gene="NOX4"
/gene_synonym="KOX; KOX-1; RENOX"
/replace="c"
/replace="t"
/db_xref="dbSNP:2289124"
variation 201
/gene="NOX4"
/gene_synonym="KOX; KOX-1; RENOX"
/replace="g"
/replace="t"
/db_xref="dbSNP:2289125"
misc_feature 240..404
/gene="NOX4"
/gene_synonym="KOX; KOX-1; RENOX"
/inference="COORDINATES:
alignment:Blast2seq::RefSeq|NM_001143837.1"
/note="primary ORF has stop codon >50 nucleotides from the
terminal splice site; nonsense-mediated decay (NMD)
candidate"
exon 297..392
/gene="NOX4"
/gene_synonym="KOX; KOX-1; RENOX"
/inference="alignment:Splign:1.39.8"
exon 393..499
/gene="NOX4"
/gene_synonym="KOX; KOX-1; RENOX"
/inference="alignment:Splign:1.39.8"
exon 500..584
/gene="NOX4"
/gene_synonym="KOX; KOX-1; RENOX"
/inference="alignment:Splign:1.39.8"
variation 546..547
/gene="NOX4"
/gene_synonym="KOX; KOX-1; RENOX"
/replace=""
/replace="c"
/db_xref="dbSNP:34078833"
exon 585..682
/gene="NOX4"
/gene_synonym="KOX; KOX-1; RENOX"
/inference="alignment:Splign:1.39.8"
exon 683..710
/gene="NOX4"
/gene_synonym="KOX; KOX-1; RENOX"
/inference="alignment:Splign:1.39.8"
exon 711..783
/gene="NOX4"
/gene_synonym="KOX; KOX-1; RENOX"
/inference="alignment:Splign:1.39.8"
exon 784..864
/gene="NOX4"
/gene_synonym="KOX; KOX-1; RENOX"
/inference="alignment:Splign:1.39.8"
exon 865..1081
/gene="NOX4"
/gene_synonym="KOX; KOX-1; RENOX"
/inference="alignment:Splign:1.39.8"
exon 1082..1246
/gene="NOX4"
/gene_synonym="KOX; KOX-1; RENOX"
/inference="alignment:Splign:1.39.8"
exon 1247..1309
/gene="NOX4"
/gene_synonym="KOX; KOX-1; RENOX"
/inference="alignment:Splign:1.39.8"
exon 1310..1370
/gene="NOX4"
/gene_synonym="KOX; KOX-1; RENOX"
/inference="alignment:Splign:1.39.8"
exon 1371..1452
/gene="NOX4"
/gene_synonym="KOX; KOX-1; RENOX"
/inference="alignment:Splign:1.39.8"
exon 1453..1572
/gene="NOX4"
/gene_synonym="KOX; KOX-1; RENOX"
/inference="alignment:Splign:1.39.8"
exon 1573..1681
/gene="NOX4"
/gene_synonym="KOX; KOX-1; RENOX"
/inference="alignment:Splign:1.39.8"
exon 1682..1750
/gene="NOX4"
/gene_synonym="KOX; KOX-1; RENOX"
/inference="alignment:Splign:1.39.8"
exon 1751..1851
/gene="NOX4"
/gene_synonym="KOX; KOX-1; RENOX"
/inference="alignment:Splign:1.39.8"
exon 1852..4375
/gene="NOX4"
/gene_synonym="KOX; KOX-1; RENOX"
/inference="alignment:Splign:1.39.8"
polyA_signal 2361..2366
/gene="NOX4"
/gene_synonym="KOX; KOX-1; RENOX"
polyA_site 2384
/gene="NOX4"
/gene_synonym="KOX; KOX-1; RENOX"
variation 2804..2805
/gene="NOX4"
/gene_synonym="KOX; KOX-1; RENOX"
/replace=""
/replace="ac"
/db_xref="dbSNP:67347334"
variation 3236..3237
/gene="NOX4"
/gene_synonym="KOX; KOX-1; RENOX"
/replace=""
/replace="c"
/db_xref="dbSNP:34486773"
variation 3336..3337
/gene="NOX4"
/gene_synonym="KOX; KOX-1; RENOX"
/replace=""
/replace="g"
/db_xref="dbSNP:35013442"
polyA_signal 4356..4361
/gene="NOX4"
/gene_synonym="KOX; KOX-1; RENOX"
polyA_site 4375
/gene="NOX4"
/gene_synonym="KOX; KOX-1; RENOX"
ORIGIN
tgagtgggcagagctgacccggtgcgggtgggagtcagggcgcccggaaaacccggctctgggtagcagaccccgcccgggctggctcggcgccgggccttcgggcttccactcagtctttgaccctcggtcctcgctcagcggcccggcaggccgcacaactgtaaccgctgccccggccgccgcccgctccttctcggtccggcgggcacagagcgcagcgcggcggggccggcggcatggctgtgtcctggaggagctggctcgccaacgaaggggttaaacacctctgcctgttcatctggctctccatgaatgtcctgcttttctggaaaaccttcttgctgtataaccaagggccagagtatcactacctccaccagatgttgggggattgtgtctaagcagagcctcagcatctgttcttaacctcaactgcagccttatccttttacccatgtgccgaacactcttggcttacctccgaggatcacagaaggttccaagcaggagaaccaggagattgttggataaaagcagaacattccatattacctgtggtgttactatctgtattttctcaggcgtgcatgtggctgcccatctggtgaatgccctcaacttctcagtgaattacagtgaagactttgttgaactgaatgcagcaagataccgagatgaggatcctagaaaacttctcttcacaactgttcctggcctgacaggggtctgcatggtggtggtgctattcctcatgatcacagcctctacatatgcaataagagtttctaactatgatatcttctggtatactcataacctcttctttgtcttctacatgctgctgacgttgcatgtttcaggagggctgctgaagtatcaaactaatttagatacccaccctcccggctgcatcagtcttaaccgaaccagctctcagaatatttccttaccagagtatttctcagaacattttcatgaacctttccctgaaggattttcaaaaccggcagagtttacccagcacaaatttgtgaagatttgtatggaagagcccagattccaagctaattttccacagacttggctttggatttctggacctttgtgcctgtactgtgccgaaagactttacaggtatatccggagcaataagccagtcaccatcatttcggtcataagtcatccctcagatgtcatggaaatccgaatggtcaaagaaaattttaaagcaagacctggtcagtatattactctacattgtcccagtgtatctgcattagaaaatcatccatttaccctcacaatgtgtccaactgaaaccaaagcaacatttggggttcatcttaaaatagtaggagactggacagaacgatttcgagatttactactgcctccatctagtcaagactccgaaattctgcccttcattcaatctagaaattatcccaagctgtatattgatggtccttttggaagtccatttgaggaatcactgaactatgaggtcagcctctgcgtggctggaggcattggagtaactccatttgcatcaatactcaacaccctgttggatgactggaaaccatacaagcttagaagactatactttatttgggtatgcagagatatccagtccttccgttggtttgcagatttactctgtatgttgcataacaagttttggcaagagaacagacctgactatgtcaacatccagctgtacctcagtcaaacagatgggatacagaagataattggagaaaaatatcatgcactgaattcaagactgtttataggacgtcctcggtggaaacttttgtttgatgaaatagcaaaatataacagaggaaaaacagttggtgttttctgttgtggacccaattcactatccaagactcttcataaactgagtaaccagaacaactcatatgggacaagatttgaatacaataaagagtctttcagctgaaaacttttgccatgaagcaggactctaaagaaggaatgagtgcaatttctaagactttgaaactcagcggaatcaatcagctgtgttatgccaaagaatagtaaggttttcttatttatgattatttaaaatggaaatgtgagaatgtggcaagatgaccgtcacattacatgtttaatctggaaaccaaagagaccctgaagaatatttgatgtgatgattcacttttcagttctcaaattaaaagaaaactgttagatgcacactgttgattttcatggtggattcaagaactccctagtgaggagctgaacttgctcaatctaaggctgattgtcgtgttcctctttaaattgtttttggttgaacaaatgcaagattgaacaaaattaaaaattcattgaagctgaaattccattttctgtgttgtgtataaacagagtagctttaatttgcaagcactccaggcaaatatattagatgtttgaaaacacagcacaagactctgtattgatacgggtactttgtgtcaatatctaatcgtctccactacttatgctaatacctctatttgatatctgaagactatatgctaactgaaccttcctcaaatgttgttatagtatctatttttatatatttttttctttttattcctctctctagggaaatatgccttcccttagcatgcattagacataatgatttaataggtccctttcatcttcatttaaatctatcactattgcatggtaatgaaaatattcctactataaattataaagggatatatatatatggatatatatatgtatatacacatatatatatacacacacacacacatatatatatatatatatatatatacacatatactaataacttttcccttttttcagcatttttgtctctattattattattgtttttttcccaggtagggtttgtcttaggctgtagcctctaaggatagttagttaatttgcactttgagaccaaaggacatcatgtgtgtcagtagggactgaatataagatttatctcctttgccacacattggtttatgatggagacattgaaagtctagtcatattcctgaacagtaaaacctgtattttaccttttaagtaagaggaaatatgatattcttattcaaacttaagtttagaatccagaatattactgtcgcactttttggtatcctgagtttccatagggaactattgggtttaaagtcaccgttggaactacactgtgtgatcttataaacttatgttccctggctatcatattcttggctcagaacaatatttcccattactatcttaagaattaaggcattcatggctcacgcctgtaatcccggcactttgggaggccaaggcaggtggatcacgaggtcagagttcaagaccagcctgaccaagttggtgaaaccccatcgctactaaaaatacaaatattaggcgggtgtggtggcgggtgcctataatcccaactactcgggagactgaggcaaagaatcgcttgaacccggtgggcggaggttgcagtgagccaagattgcaccactgcactccagcctgggtgacagagcaagattccatctcaaaaaaaaaaaaaaaaaaaaaaaaaaagaattaaagcattcatacagtttagtgattttgtttagtagtcggctatcaattgctatcaaatataacactgctgaaatcagcagtgtgacttaccttgccattgttaaaatgttacataaaacataacatgatagatgctaaggcctttttttgctataattcaccaatagcaatcaagcatgctaacccatactgaatgatatttacttgtagatatttcttcctttccttgaaattctcctttctatggaaagaagatgaacccaaaaaagtgataggaaatgtggaatgctcatgcagatttagctctgaaggcatatttaataactagtatgtcttgacaacagtctttagattaaaaagaattttcatggaaacatttaacagaaagaactagtaaaaagacactttgagttagtccaggcttaatgtgcaatactgactctatactgatcataatttatttatgcgatcatattaatagacctaatttcattaaaacaggtagaagatttttcaaaagaaagatgatgtttcaaagctggtctgccattctagatgagcctccttgcttatttaagttccagtaggtgttcaaatgttaaatgttaaacataggtcatctttgcttctgcagggcttcatcttgcatgtttaagagaactttgttttattttgagggattatttctctggggatcattcttataatacaagccttaaatcactaattttagtagcaataaatgttaaaattgaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:50507 -> Molecular function: GO:0000166 [nucleotide binding] evidence: TAS
GeneID:50507 -> Molecular function: GO:0009055 [electron carrier activity] evidence: TAS
GeneID:50507 -> Molecular function: GO:0016174 [NAD(P)H oxidase activity] evidence: TAS
GeneID:50507 -> Molecular function: GO:0016175 [superoxide-generating NADPH oxidase activity] evidence: IEA
GeneID:50507 -> Molecular function: GO:0019826 [oxygen sensor activity] evidence: TAS
GeneID:50507 -> Molecular function: GO:0020037 [heme binding] evidence: TAS
GeneID:50507 -> Molecular function: GO:0050660 [flavin adenine dinucleotide binding] evidence: TAS
GeneID:50507 -> Molecular function: GO:0072341 [modified amino acid binding] evidence: IDA
GeneID:50507 -> Biological process: GO:0000902 [cell morphogenesis] evidence: ISS
GeneID:50507 -> Biological process: GO:0001666 [response to hypoxia] evidence: IEA
GeneID:50507 -> Biological process: GO:0006954 [inflammatory response] evidence: TAS
GeneID:50507 -> Biological process: GO:0007569 [cell aging] evidence: ISS
GeneID:50507 -> Biological process: GO:0008285 [negative regulation of cell proliferation] evidence: ISS
GeneID:50507 -> Biological process: GO:0014911 [positive regulation of smooth muscle cell migration] evidence: IEA
GeneID:50507 -> Biological process: GO:0035051 [cardiocyte differentiation] evidence: IEA
GeneID:50507 -> Biological process: GO:0042554 [superoxide anion generation] evidence: ISS
GeneID:50507 -> Biological process: GO:0043065 [positive regulation of apoptotic process] evidence: IEA
GeneID:50507 -> Biological process: GO:0043406 [positive regulation of MAP kinase activity] evidence: IEA
GeneID:50507 -> Biological process: GO:0045453 [bone resorption] evidence: IEA
GeneID:50507 -> Biological process: GO:0050667 [homocysteine metabolic process] evidence: IDA
GeneID:50507 -> Biological process: GO:0051496 [positive regulation of stress fiber assembly] evidence: IEA
GeneID:50507 -> Biological process: GO:0051897 [positive regulation of protein kinase B signaling cascade] evidence: IEA
GeneID:50507 -> Biological process: GO:0055114 [oxidation-reduction process] evidence: IDA
GeneID:50507 -> Biological process: GO:0070374 [positive regulation of ERK1 and ERK2 cascade] evidence: IEA
GeneID:50507 -> Biological process: GO:0071320 [cellular response to cAMP] evidence: IEA
GeneID:50507 -> Biological process: GO:0071333 [cellular response to glucose stimulus] evidence: IEA
GeneID:50507 -> Biological process: GO:0071480 [cellular response to gamma radiation] evidence: IEA
GeneID:50507 -> Biological process: GO:0071560 [cellular response to transforming growth factor beta stimulus] evidence: IEA
GeneID:50507 -> Biological process: GO:0072593 [reactive oxygen species metabolic process] evidence: IDA
GeneID:50507 -> Biological process: GO:2000379 [positive regulation of reactive oxygen species metabolic process] evidence: IEA
GeneID:50507 -> Biological process: GO:2000573 [positive regulation of DNA biosynthetic process] evidence: IEA
GeneID:50507 -> Cellular component: GO:0005634 [nucleus] evidence: IEA
GeneID:50507 -> Cellular component: GO:0005739 [mitochondrion] evidence: IEA
GeneID:50507 -> Cellular component: GO:0005789 [endoplasmic reticulum membrane] evidence: IEA
GeneID:50507 -> Cellular component: GO:0005925 [focal adhesion] evidence: IEA
GeneID:50507 -> Cellular component: GO:0016021 [integral to membrane] evidence: TAS
GeneID:50507 -> Cellular component: GO:0016324 [apical plasma membrane] evidence: IEA
GeneID:50507 -> Cellular component: GO:0043020 [NADPH oxidase complex] evidence: IEA
GeneID:50507 -> Cellular component: GO:0048471 [perinuclear region of cytoplasm] evidence: IEA
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