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2024-03-28 20:44:51, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_199187               1439 bp    mRNA    linear   PRI 15-JUL-2013
DEFINITION  Homo sapiens keratin 18 (KRT18), transcript variant 2, mRNA.
ACCESSION   NM_199187
VERSION     NM_199187.1  GI:40354194
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1439)
  AUTHORS   Fortier,A.M., Asselin,E. and Cadrin,M.
  TITLE     Keratin 8 and 18 loss in epithelial cancer cells increases
            collective cell migration and cisplatin sensitivity through
            claudin1 up-regulation
  JOURNAL   J. Biol. Chem. 288 (16), 11555-11571 (2013)
   PUBMED   23449973
  REMARK    GeneRIF: K8/18 expression can influence the phenotype of epithelial
            cancer cells at a transcriptional level and supports the hypothesis
            that keratins play an active role in cancer progression.
REFERENCE   2  (bases 1 to 1439)
  AUTHORS   Mathew,J., Loranger,A., Gilbert,S., Faure,R. and Marceau,N.
  TITLE     Keratin 8/18 regulation of glucose metabolism in normal versus
            cancerous hepatic cells through differential modulation of
            hexokinase status and insulin signaling
  JOURNAL   Exp. Cell Res. 319 (4), 474-486 (2013)
   PUBMED   23164509
  REMARK    GeneRIF: A key K8/K18 regulation of glucose metabolism in normal
            and cancerous hepatic cells through differential modulations of
            mitochondrial hexokinase status and insulin-mediated signaling.
REFERENCE   3  (bases 1 to 1439)
  AUTHORS   Iyer,S.V., Dange,P.P., Alam,H., Sawant,S.S., Ingle,A.D.,
            Borges,A.M., Shirsat,N.V., Dalal,S.N. and Vaidya,M.M.
  TITLE     Understanding the role of keratins 8 and 18 in neoplastic potential
            of breast cancer derived cell lines
  JOURNAL   PLoS ONE 8 (1), E53532 (2013)
   PUBMED   23341946
  REMARK    GeneRIF: These results indicate the role of K8/18 in modulating
            invasion in breast cancer.
REFERENCE   4  (bases 1 to 1439)
  AUTHORS   Wang,Y., Zhu,J.F., Liu,Y.Y. and Han,G.P.
  TITLE     An analysis of cyclin D1, cytokeratin 5/6 and cytokeratin 8/18
            expression in breast papillomas and papillary carcinomas
  JOURNAL   Diagn Pathol 8, 8 (2013)
   PUBMED   23327593
  REMARK    GeneRIF: Report keratin 18 expression in breast papillomas and
            papillary carcinoma.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1439)
  AUTHORS   Valva,P., Casciato,P., Lezama,C., Galoppo,M., Gadano,A.,
            Galdame,O., Galoppo,M.C., Mullen,E., De Matteo,E. and Preciado,M.V.
  TITLE     Serum apoptosis markers related to liver damage in chronic
            hepatitis C: sFas as a marker of advanced fibrosis in children and
            adults while M30 of severe steatosis only in children
  JOURNAL   PLoS ONE 8 (1), E53519 (2013)
   PUBMED   23326448
  REMARK    GeneRIF: Serum sFas could be considered a possible marker of
            advanced fibrosis both in pediatric and adult patient with chronic
            hepatitis C as well as M30 might be a good predictor of steatosis
            severity in children.
REFERENCE   6  (bases 1 to 1439)
  AUTHORS   Omary,M.B., Baxter,G.T., Chou,C.F., Riopel,C.L., Lin,W.Y. and
            Strulovici,B.
  TITLE     PKC epsilon-related kinase associates with and phosphorylates
            cytokeratin 8 and 18
  JOURNAL   J. Cell Biol. 117 (3), 583-593 (1992)
   PUBMED   1374067
REFERENCE   7  (bases 1 to 1439)
  AUTHORS   Heath,P., Elvin,P., Jenner,D., Gammack,A., Morten,J. and Markham,A.
  TITLE     Localisation of a cDNA clone for human cytokeratin 18 to chromosome
            17p11-p12 by in situ hybridisation
  JOURNAL   Hum. Genet. 85 (6), 669-670 (1990)
   PUBMED   1699878
REFERENCE   8  (bases 1 to 1439)
  AUTHORS   Waseem,A., Gough,A.C., Spurr,N.K. and Lane,E.B.
  TITLE     Localization of the gene for human simple epithelial keratin 18 to
            chromosome 12 using polymerase chain reaction
  JOURNAL   Genomics 7 (2), 188-194 (1990)
   PUBMED   1693358
REFERENCE   9  (bases 1 to 1439)
  AUTHORS   Waseem,A., Alexander,C.M., Steel,J.B. and Lane,E.B.
  TITLE     Embryonic simple epithelial keratins 8 and 18: chromosomal location
            emphasizes difference from other keratin pairs
  JOURNAL   New Biol. 2 (5), 464-478 (1990)
   PUBMED   1705144
REFERENCE   10 (bases 1 to 1439)
  AUTHORS   Romano,V., Hatzfeld,M., Magin,T.M., Zimbelmann,R., Franke,W.W.,
            Maier,G. and Ponstingl,H.
  TITLE     Cytokeratin expression in simple epithelia. I. Identification of
            mRNA coding for human cytokeratin no. 18 by a cDNA clone
  JOURNAL   Differentiation 30 (3), 244-253 (1986)
   PUBMED   2422083
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BG753529.1, CD106591.1,
            X12881.1 and BC000180.2.
            
            Summary: KRT18 encodes the type I intermediate filament chain
            keratin 18. Keratin 18, together with its filament partner keratin
            8, are perhaps the most commonly found members of the intermediate
            filament gene family. They are expressed in single layer epithelial
            tissues of the body. Mutations in this gene have been linked to
            cryptogenic cirrhosis. Two transcript variants encoding the same
            protein have been found for this gene. [provided by RefSeq, Jul
            2008].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1 and 2 both encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: BC000180.2, BC072017.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    ERS025083, ERS025084 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-99                BG753529.1         1-99
            100-726             CD106591.1         146-772
            727-1421            X12881.1           704-1398
            1422-1439           BC000180.2         1394-1411
FEATURES             Location/Qualifiers
     source          1..1439
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q13"
     gene            1..1439
                     /gene="KRT18"
                     /gene_synonym="CYK18; K18"
                     /note="keratin 18"
                     /db_xref="GeneID:3875"
                     /db_xref="HGNC:6430"
                     /db_xref="HPRD:01020"
                     /db_xref="MIM:148070"
     exon            1..68
                     /gene="KRT18"
                     /gene_synonym="CYK18; K18"
                     /inference="alignment:Splign:1.39.8"
     variation       26
                     /gene="KRT18"
                     /gene_synonym="CYK18; K18"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:115941399"
     variation       64
                     /gene="KRT18"
                     /gene_synonym="CYK18; K18"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:79477652"
     exon            69..486
                     /gene="KRT18"
                     /gene_synonym="CYK18; K18"
                     /inference="alignment:Splign:1.39.8"
     CDS             70..1362
                     /gene="KRT18"
                     /gene_synonym="CYK18; K18"
                     /note="cytokeratin 18; cell proliferation-inducing protein
                     46; CK-18; keratin-18; cytokeratin-18; cell
                     proliferation-inducing gene 46 protein"
                     /codon_start=1
                     /product="keratin, type I cytoskeletal 18"
                     /protein_id="NP_954657.1"
                     /db_xref="GI:40354195"
                     /db_xref="CCDS:CCDS31809.1"
                     /db_xref="GeneID:3875"
                     /db_xref="HGNC:6430"
                     /db_xref="HPRD:01020"
                     /db_xref="MIM:148070"
                     /translation="
MSFTTRSTFSTNYRSLGSVQAPSYGARPVSSAASVYAGAGGSGSRISVSRSTSFRGGMGSGGLATGIAGGLAGMGGIQNEKETMQSLNDRLASYLDRVRSLETENRRLESKIREHLEKKGPQVRDWSHYFKIIEDLRAQIFANTVDNARIVLQIDNARLAADDFRVKYETELAMRQSVENDIHGLRKVIDDTNITRLQLETEIEALKEELLFMKKNHEEEVKGLQAQIASSGLTVEVDAPKSQDLAKIMADIRAQYDELARKNREELDKYWSQQIEESTTVVTTQSAEVGAAETTLTELRRTVQSLEIDLDSMRNLKASLENSLREVEARYALQMEQLNGILLHLESELAQTRAEGQRQAQEYEALLNIKVKLEAEIATYRRLLEDGEDFNLGDALDSSNSMQTIQKTTTRRIVDGKVVSETNDTKVLRH
"
     misc_feature    73..306
                     /gene="KRT18"
                     /gene_synonym="CYK18; K18"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P05783.2);
                     Region: Head"
     misc_feature    73..75
                     /gene="KRT18"
                     /gene_synonym="CYK18; K18"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="N-acetylserine; propagated from
                     UniProtKB/Swiss-Prot (P05783.2); acetylation site"
     misc_feature    88..90
                     /gene="KRT18"
                     /gene_synonym="CYK18; K18"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (P05783.2); phosphorylation site"
     misc_feature    97..99
                     /gene="KRT18"
                     /gene_synonym="CYK18; K18"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (P05783.2); phosphorylation site"
     misc_feature    106..108
                     /gene="KRT18"
                     /gene_synonym="CYK18; K18"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     misc_feature    112..114
                     /gene="KRT18"
                     /gene_synonym="CYK18; K18"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (P05783.2); phosphorylation site"
     misc_feature    121..123
                     /gene="KRT18"
                     /gene_synonym="CYK18; K18"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (P05783.2); phosphorylation site"
     misc_feature    157..159
                     /gene="KRT18"
                     /gene_synonym="CYK18; K18"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="glycosylation site"
     misc_feature    160..162
                     /gene="KRT18"
                     /gene_synonym="CYK18; K18"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="glycosylation site"
     misc_feature    160..162
                     /gene="KRT18"
                     /gene_synonym="CYK18; K18"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine, alternate; propagated from
                     UniProtKB/Swiss-Prot (P05783.2); phosphorylation site"
     misc_feature    169..171
                     /gene="KRT18"
                     /gene_synonym="CYK18; K18"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine, by CDK1; propagated from
                     UniProtKB/Swiss-Prot (P05783.2); phosphorylation site"
     misc_feature    169..171
                     /gene="KRT18"
                     /gene_synonym="CYK18; K18"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
                     /db_xref="HPRD:00302"
     misc_feature    175..177
                     /gene="KRT18"
                     /gene_synonym="CYK18; K18"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphotyrosine; propagated from
                     UniProtKB/Swiss-Prot (P05783.2); phosphorylation site"
     misc_feature    193..195
                     /gene="KRT18"
                     /gene_synonym="CYK18; K18"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (P05783.2); phosphorylation site"
     misc_feature    214..216
                     /gene="KRT18"
                     /gene_synonym="CYK18; K18"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="glycosylation site"
     misc_feature    226..228
                     /gene="KRT18"
                     /gene_synonym="CYK18; K18"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine, by CAMK, PKC/PRKCE and AURKA;
                     propagated from UniProtKB/Swiss-Prot (P05783.2);
                     phosphorylation site"
     misc_feature    226..228
                     /gene="KRT18"
                     /gene_synonym="CYK18; K18"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
                     /citation=[6]
                     /db_xref="HPRD:01498"
     misc_feature    226..228
                     /gene="KRT18"
                     /gene_synonym="CYK18; K18"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
                     /citation=[6]
                     /db_xref="HPRD:02092"
     misc_feature    226..228
                     /gene="KRT18"
                     /gene_synonym="CYK18; K18"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
                     /citation=[6]
                     /db_xref="HPRD:01500"
     misc_feature    226..228
                     /gene="KRT18"
                     /gene_synonym="CYK18; K18"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
                     /citation=[6]
                     /db_xref="HPRD:06532"
     misc_feature    247..249
                     /gene="KRT18"
                     /gene_synonym="CYK18; K18"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (P05783.2); phosphorylation site"
     misc_feature    262..264
                     /gene="KRT18"
                     /gene_synonym="CYK18; K18"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphothreonine; propagated from
                     UniProtKB/Swiss-Prot (P05783.2); phosphorylation site"
     misc_feature    262..264
                     /gene="KRT18"
                     /gene_synonym="CYK18; K18"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     misc_feature    277..1188
                     /gene="KRT18"
                     /gene_synonym="CYK18; K18"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P05783.2);
                     Region: Necessary for interaction with PNN"
     misc_feature    298..453
                     /gene="KRT18"
                     /gene_synonym="CYK18; K18"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P05783.2);
                     Region: Interaction with TRADD"
     misc_feature    304..1236
                     /gene="KRT18"
                     /gene_synonym="CYK18; K18"
                     /note="Intermediate filament protein; Region: Filament;
                     pfam00038"
                     /db_xref="CDD:200948"
     misc_feature    307..1230
                     /gene="KRT18"
                     /gene_synonym="CYK18; K18"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P05783.2);
                     Region: Rod"
     misc_feature    307..414
                     /gene="KRT18"
                     /gene_synonym="CYK18; K18"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P05783.2);
                     Region: Coil 1A"
     misc_feature    367..369
                     /gene="KRT18"
                     /gene_synonym="CYK18; K18"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (P05783.2); phosphorylation site"
     misc_feature    415..465
                     /gene="KRT18"
                     /gene_synonym="CYK18; K18"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P05783.2);
                     Region: Linker 1"
     misc_feature    460..462
                     /gene="KRT18"
                     /gene_synonym="CYK18; K18"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="N6-acetyllysine; propagated from
                     UniProtKB/Swiss-Prot (P05783.2); acetylation site"
     misc_feature    466..741
                     /gene="KRT18"
                     /gene_synonym="CYK18; K18"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P05783.2);
                     Region: Coil 1B"
     misc_feature    598..600
                     /gene="KRT18"
                     /gene_synonym="CYK18; K18"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (P05783.2); phosphorylation site"
     misc_feature    742..813
                     /gene="KRT18"
                     /gene_synonym="CYK18; K18"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P05783.2);
                     Region: Linker 12"
     misc_feature    781..786
                     /gene="KRT18"
                     /gene_synonym="CYK18; K18"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Cleavage, by caspase-3, caspase-6 or caspase-7;
                     propagated from UniProtKB/Swiss-Prot (P05783.2); cleavage
                     site"
     misc_feature    781..783
                     /gene="KRT18"
                     /gene_synonym="CYK18; K18"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="proteolytic cleavage site; modified site"
                     /db_xref="HPRD:02799"
     misc_feature    781..783
                     /gene="KRT18"
                     /gene_synonym="CYK18; K18"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="proteolytic cleavage site; modified site"
                     /db_xref="HPRD:03321"
     misc_feature    781..783
                     /gene="KRT18"
                     /gene_synonym="CYK18; K18"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="proteolytic cleavage site; modified site"
                     /db_xref="HPRD:03457"
     misc_feature    796..1242
                     /gene="KRT18"
                     /gene_synonym="CYK18; K18"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P05783.2);
                     Region: Interaction with DNAJB6"
     misc_feature    814..1230
                     /gene="KRT18"
                     /gene_synonym="CYK18; K18"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P05783.2);
                     Region: Coil 2"
     misc_feature    880..882
                     /gene="KRT18"
                     /gene_synonym="CYK18; K18"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Stutter; propagated from UniProtKB/Swiss-Prot
                     (P05783.2); other site"
     misc_feature    973..975
                     /gene="KRT18"
                     /gene_synonym="CYK18; K18"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphothreonine; propagated from
                     UniProtKB/Swiss-Prot (P05783.2); phosphorylation site"
     misc_feature    1024..1026
                     /gene="KRT18"
                     /gene_synonym="CYK18; K18"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (P05783.2); phosphorylation site"
     misc_feature    1060..1062
                     /gene="KRT18"
                     /gene_synonym="CYK18; K18"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Stutter; propagated from UniProtKB/Swiss-Prot
                     (P05783.2); other site"
     misc_feature    1231..1359
                     /gene="KRT18"
                     /gene_synonym="CYK18; K18"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P05783.2);
                     Region: Tail"
     misc_feature    1258..1260
                     /gene="KRT18"
                     /gene_synonym="CYK18; K18"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="proteolytic cleavage site; modified site"
                     /db_xref="HPRD:02799"
     misc_feature    1264..1266
                     /gene="KRT18"
                     /gene_synonym="CYK18; K18"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (P05783.2); phosphorylation site"
     misc_feature    1264..1266
                     /gene="KRT18"
                     /gene_synonym="CYK18; K18"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     misc_feature    1279..1281
                     /gene="KRT18"
                     /gene_synonym="CYK18; K18"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphothreonine; propagated from
                     UniProtKB/Swiss-Prot (P05783.2); phosphorylation site"
     misc_feature    1345..1347
                     /gene="KRT18"
                     /gene_synonym="CYK18; K18"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="N6-acetyllysine; propagated from
                     UniProtKB/Swiss-Prot (P05783.2); acetylation site"
     variation       74
                     /gene="KRT18"
                     /gene_synonym="CYK18; K18"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:369198778"
     variation       75
                     /gene="KRT18"
                     /gene_synonym="CYK18; K18"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:141170056"
     variation       80
                     /gene="KRT18"
                     /gene_synonym="CYK18; K18"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:76301931"
     variation       117
                     /gene="KRT18"
                     /gene_synonym="CYK18; K18"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:80354424"
     variation       119
                     /gene="KRT18"
                     /gene_synonym="CYK18; K18"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:79476176"
     variation       122
                     /gene="KRT18"
                     /gene_synonym="CYK18; K18"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:147350452"
     variation       138
                     /gene="KRT18"
                     /gene_synonym="CYK18; K18"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:141066547"
     variation       145
                     /gene="KRT18"
                     /gene_synonym="CYK18; K18"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:78514003"
     variation       146
                     /gene="KRT18"
                     /gene_synonym="CYK18; K18"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11551634"
     variation       148
                     /gene="KRT18"
                     /gene_synonym="CYK18; K18"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:77825282"
     variation       152
                     /gene="KRT18"
                     /gene_synonym="CYK18; K18"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:74379840"
     variation       161
                     /gene="KRT18"
                     /gene_synonym="CYK18; K18"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:374064321"
     variation       163
                     /gene="KRT18"
                     /gene_synonym="CYK18; K18"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:74953757"
     variation       171
                     /gene="KRT18"
                     /gene_synonym="CYK18; K18"
                     /replace="a"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:78343594"
     variation       181
                     /gene="KRT18"
                     /gene_synonym="CYK18; K18"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:77999286"
     variation       183
                     /gene="KRT18"
                     /gene_synonym="CYK18; K18"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:75380684"
     variation       186
                     /gene="KRT18"
                     /gene_synonym="CYK18; K18"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:75174163"
     variation       196
                     /gene="KRT18"
                     /gene_synonym="CYK18; K18"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:75441140"
     variation       203
                     /gene="KRT18"
                     /gene_synonym="CYK18; K18"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:200221269"
     variation       210
                     /gene="KRT18"
                     /gene_synonym="CYK18; K18"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:80004568"
     variation       217
                     /gene="KRT18"
                     /gene_synonym="CYK18; K18"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:78479490"
     variation       218
                     /gene="KRT18"
                     /gene_synonym="CYK18; K18"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:11551633"
     variation       232
                     /gene="KRT18"
                     /gene_synonym="CYK18; K18"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:78718957"
     variation       236
                     /gene="KRT18"
                     /gene_synonym="CYK18; K18"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:76183244"
     variation       246
                     /gene="KRT18"
                     /gene_synonym="CYK18; K18"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:76187914"
     variation       249
                     /gene="KRT18"
                     /gene_synonym="CYK18; K18"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:186267053"
     variation       262..285
                     /gene="KRT18"
                     /gene_synonym="CYK18; K18"
                     /replace=""
                     /replace="accgggatagccgggggtctggca"
                     /db_xref="dbSNP:267607417"
     variation       264
                     /gene="KRT18"
                     /gene_synonym="CYK18; K18"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:79913669"
     variation       270
                     /gene="KRT18"
                     /gene_synonym="CYK18; K18"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:77364359"
     variation       274
                     /gene="KRT18"
                     /gene_synonym="CYK18; K18"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:11551624"
     variation       307
                     /gene="KRT18"
                     /gene_synonym="CYK18; K18"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199572098"
     variation       321
                     /gene="KRT18"
                     /gene_synonym="CYK18; K18"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:79346135"
     variation       338
                     /gene="KRT18"
                     /gene_synonym="CYK18; K18"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:11551641"
     variation       344
                     /gene="KRT18"
                     /gene_synonym="CYK18; K18"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11551623"
     variation       351
                     /gene="KRT18"
                     /gene_synonym="CYK18; K18"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:386834224"
     variation       374
                     /gene="KRT18"
                     /gene_synonym="CYK18; K18"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:144926827"
     variation       376
                     /gene="KRT18"
                     /gene_synonym="CYK18; K18"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:61136606"
     variation       378
                     /gene="KRT18"
                     /gene_synonym="CYK18; K18"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:373362435"
     variation       385
                     /gene="KRT18"
                     /gene_synonym="CYK18; K18"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11551638"
     variation       399
                     /gene="KRT18"
                     /gene_synonym="CYK18; K18"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11551621"
     variation       411
                     /gene="KRT18"
                     /gene_synonym="CYK18; K18"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:11551637"
     variation       425
                     /gene="KRT18"
                     /gene_synonym="CYK18; K18"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:147945345"
     variation       436
                     /gene="KRT18"
                     /gene_synonym="CYK18; K18"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:11551629"
     variation       439
                     /gene="KRT18"
                     /gene_synonym="CYK18; K18"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:11551632"
     variation       447
                     /gene="KRT18"
                     /gene_synonym="CYK18; K18"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:140324943"
     variation       452
                     /gene="KRT18"
                     /gene_synonym="CYK18; K18"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:57758506"
     exon            487..569
                     /gene="KRT18"
                     /gene_synonym="CYK18; K18"
                     /inference="alignment:Splign:1.39.8"
     variation       507
                     /gene="KRT18"
                     /gene_synonym="CYK18; K18"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:370728079"
     variation       515
                     /gene="KRT18"
                     /gene_synonym="CYK18; K18"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200694483"
     variation       517
                     /gene="KRT18"
                     /gene_synonym="CYK18; K18"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:59979366"
     variation       542
                     /gene="KRT18"
                     /gene_synonym="CYK18; K18"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:369948432"
     variation       543
                     /gene="KRT18"
                     /gene_synonym="CYK18; K18"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:78791501"
     variation       550
                     /gene="KRT18"
                     /gene_synonym="CYK18; K18"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:11551626"
     variation       558
                     /gene="KRT18"
                     /gene_synonym="CYK18; K18"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:77832070"
     exon            570..726
                     /gene="KRT18"
                     /gene_synonym="CYK18; K18"
                     /inference="alignment:Splign:1.39.8"
     variation       571..572
                     /gene="KRT18"
                     /gene_synonym="CYK18; K18"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:17856017"
     variation       581
                     /gene="KRT18"
                     /gene_synonym="CYK18; K18"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:11551625"
     variation       594
                     /gene="KRT18"
                     /gene_synonym="CYK18; K18"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:369743947"
     variation       645
                     /gene="KRT18"
                     /gene_synonym="CYK18; K18"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11551628"
     variation       646
                     /gene="KRT18"
                     /gene_synonym="CYK18; K18"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:11170343"
     variation       654
                     /gene="KRT18"
                     /gene_synonym="CYK18; K18"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:115544685"
     variation       668
                     /gene="KRT18"
                     /gene_synonym="CYK18; K18"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:146788536"
     variation       672
                     /gene="KRT18"
                     /gene_synonym="CYK18; K18"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:11551622"
     variation       720
                     /gene="KRT18"
                     /gene_synonym="CYK18; K18"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:372594060"
     variation       721
                     /gene="KRT18"
                     /gene_synonym="CYK18; K18"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:375823747"
     exon            727..891
                     /gene="KRT18"
                     /gene_synonym="CYK18; K18"
                     /inference="alignment:Splign:1.39.8"
     variation       758
                     /gene="KRT18"
                     /gene_synonym="CYK18; K18"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:58472472"
     variation       789
                     /gene="KRT18"
                     /gene_synonym="CYK18; K18"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:1049159"
     variation       810
                     /gene="KRT18"
                     /gene_synonym="CYK18; K18"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:17174405"
     STS             811..988
                     /gene="KRT18"
                     /gene_synonym="CYK18; K18"
                     /standard_name="G66248"
                     /db_xref="UniSTS:230089"
     variation       816
                     /gene="KRT18"
                     /gene_synonym="CYK18; K18"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:191325805"
     variation       830
                     /gene="KRT18"
                     /gene_synonym="CYK18; K18"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:11551642"
     variation       831
                     /gene="KRT18"
                     /gene_synonym="CYK18; K18"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:145578755"
     variation       851
                     /gene="KRT18"
                     /gene_synonym="CYK18; K18"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:57354642"
     variation       858
                     /gene="KRT18"
                     /gene_synonym="CYK18; K18"
                     /replace="c"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:11551643"
     exon            892..1017
                     /gene="KRT18"
                     /gene_synonym="CYK18; K18"
                     /inference="alignment:Splign:1.39.8"
     variation       896
                     /gene="KRT18"
                     /gene_synonym="CYK18; K18"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:61696408"
     variation       923
                     /gene="KRT18"
                     /gene_synonym="CYK18; K18"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:59112368"
     variation       945
                     /gene="KRT18"
                     /gene_synonym="CYK18; K18"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:141750671"
     variation       951
                     /gene="KRT18"
                     /gene_synonym="CYK18; K18"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:150137089"
     variation       953
                     /gene="KRT18"
                     /gene_synonym="CYK18; K18"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:267607418"
     variation       959
                     /gene="KRT18"
                     /gene_synonym="CYK18; K18"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:115810585"
     variation       969
                     /gene="KRT18"
                     /gene_synonym="CYK18; K18"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:11551636"
     variation       993
                     /gene="KRT18"
                     /gene_synonym="CYK18; K18"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:149270992"
     variation       994
                     /gene="KRT18"
                     /gene_synonym="CYK18; K18"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199930351"
     exon            1018..1241
                     /gene="KRT18"
                     /gene_synonym="CYK18; K18"
                     /inference="alignment:Splign:1.39.8"
     variation       1056
                     /gene="KRT18"
                     /gene_synonym="CYK18; K18"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:371513958"
     variation       1057
                     /gene="KRT18"
                     /gene_synonym="CYK18; K18"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:147365823"
     variation       1062
                     /gene="KRT18"
                     /gene_synonym="CYK18; K18"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:58138700"
     STS             1064..1252
                     /gene="KRT18"
                     /gene_synonym="CYK18; K18"
                     /standard_name="SHGC-11808"
                     /db_xref="UniSTS:27701"
     variation       1071
                     /gene="KRT18"
                     /gene_synonym="CYK18; K18"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:11542066"
     variation       1081
                     /gene="KRT18"
                     /gene_synonym="CYK18; K18"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11551635"
     variation       1086
                     /gene="KRT18"
                     /gene_synonym="CYK18; K18"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:372449912"
     variation       1087
                     /gene="KRT18"
                     /gene_synonym="CYK18; K18"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:57370769"
     STS             1096..1174
                     /gene="KRT18"
                     /gene_synonym="CYK18; K18"
                     /standard_name="G66074"
                     /db_xref="UniSTS:230065"
     variation       1105
                     /gene="KRT18"
                     /gene_synonym="CYK18; K18"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:143380812"
     STS             1139..1308
                     /gene="KRT18"
                     /gene_synonym="CYK18; K18"
                     /standard_name="PMC17321P1"
                     /db_xref="UniSTS:271636"
     variation       1155
                     /gene="KRT18"
                     /gene_synonym="CYK18; K18"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:144702029"
     variation       1186
                     /gene="KRT18"
                     /gene_synonym="CYK18; K18"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:17467"
     variation       1211
                     /gene="KRT18"
                     /gene_synonym="CYK18; K18"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:147541172"
     variation       1213
                     /gene="KRT18"
                     /gene_synonym="CYK18; K18"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:11551627"
     STS             1227..1407
                     /gene="KRT18"
                     /gene_synonym="CYK18; K18"
                     /standard_name="STS-N95819"
                     /db_xref="UniSTS:81461"
     exon            1242..1421
                     /gene="KRT18"
                     /gene_synonym="CYK18; K18"
                     /inference="alignment:Splign:1.39.8"
     variation       1297
                     /gene="KRT18"
                     /gene_synonym="CYK18; K18"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:1063607"
     variation       1299
                     /gene="KRT18"
                     /gene_synonym="CYK18; K18"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:386834225"
     variation       1301
                     /gene="KRT18"
                     /gene_synonym="CYK18; K18"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:148580152"
     variation       1304
                     /gene="KRT18"
                     /gene_synonym="CYK18; K18"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:146080391"
     variation       1305
                     /gene="KRT18"
                     /gene_synonym="CYK18; K18"
                     /replace="a"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:142940942"
     variation       1337
                     /gene="KRT18"
                     /gene_synonym="CYK18; K18"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200552337"
     variation       1351
                     /gene="KRT18"
                     /gene_synonym="CYK18; K18"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:709170"
     variation       1389
                     /gene="KRT18"
                     /gene_synonym="CYK18; K18"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:377238570"
     polyA_signal    1402..1407
                     /gene="KRT18"
                     /gene_synonym="CYK18; K18"
     polyA_site      1421
                     /gene="KRT18"
                     /gene_synonym="CYK18; K18"
ORIGIN      
gcagcctcgagggccaacaacacctgctgtccgtgtccatgcccggttggccaccccgtttctgggggcatgagcttcaccactcgctccaccttctccaccaactaccggtccctgggctctgtccaggcgcccagctacggcgcccggccggtcagcagcgcggccagcgtctatgcaggcgctgggggctctggttcccggatctccgtgtcccgctccaccagcttcaggggcggcatggggtccgggggcctggccaccgggatagccgggggtctggcaggaatgggaggcatccagaacgagaaggagaccatgcaaagcctgaacgaccgcctggcctcttacctggacagagtgaggagcctggagaccgagaaccggaggctggagagcaaaatccgggagcacttggagaagaagggaccccaggtcagagactggagccattacttcaagatcatcgaggacctgagggctcagatcttcgcaaatactgtggacaatgcccgcatcgttctgcagattgacaatgcccgtcttgctgctgatgactttagagtcaagtatgagacagagctggccatgcgccagtctgtggagaacgacatccatgggctccgcaaggtcattgatgacaccaatatcacacgactgcagctggagacagagatcgaggctctcaaggaggagctgctcttcatgaagaagaaccacgaagaggaagtaaaaggcctacaagcccagattgccagctctgggttgaccgtggaggtagatgcccccaaatctcaggacctcgccaagatcatggcagacatccgggcccaatatgacgagctggctcggaagaaccgagaggagctagacaagtactggtctcagcagattgaggagagcaccacagtggtcaccacacagtctgctgaggttggagctgctgagacgacgctcacagagctgagacgtacagtccagtccttggagatcgacctggactccatgagaaatctgaaggccagcttggagaacagcctgagggaggtggaggcccgctacgccctacagatggagcagctcaacgggatcctgctgcaccttgagtcagagctggcacagacccgggcagagggacagcgccaggcccaggagtatgaggccctgctgaacatcaaggtcaagctggaggctgagatcgccacctaccgccgcctgctggaagatggcgaggactttaatcttggtgatgccttggacagcagcaactccatgcaaaccatccaaaagaccaccacccgccggatagtggatggcaaagtggtgtctgagaccaatgacaccaaagttctgaggcattaagccagcagaagcagggtaccctttggggagcaggaggccaataaaaagttcagagttcaaaaaaaaaaaaaaaaaaa
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:3875 -> Molecular function: GO:0005198 [structural molecule activity] evidence: IEA
            GeneID:3875 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
            GeneID:3875 -> Molecular function: GO:0097110 [scaffold protein binding] evidence: IPI
            GeneID:3875 -> Biological process: GO:0006915 [apoptotic process] evidence: IEA
            GeneID:3875 -> Biological process: GO:0007049 [cell cycle] evidence: IEA
            GeneID:3875 -> Biological process: GO:0009653 [anatomical structure morphogenesis] evidence: TAS
            GeneID:3875 -> Biological process: GO:0019048 [modulation by virus of host morphology or physiology] evidence: IEA
            GeneID:3875 -> Biological process: GO:0033209 [tumor necrosis factor-mediated signaling pathway] evidence: IEA
            GeneID:3875 -> Biological process: GO:0043000 [Golgi to plasma membrane CFTR protein transport] evidence: IDA
            GeneID:3875 -> Biological process: GO:0043066 [negative regulation of apoptotic process] evidence: IDA
            GeneID:3875 -> Cellular component: GO:0005730 [nucleolus] evidence: IEA
            GeneID:3875 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA
            GeneID:3875 -> Cellular component: GO:0005815 [microtubule organizing center] evidence: IDA
            GeneID:3875 -> Cellular component: GO:0005882 [intermediate filament] evidence: IDA
            GeneID:3875 -> Cellular component: GO:0034451 [centriolar satellite] evidence: IDA
            GeneID:3875 -> Cellular component: GO:0045095 [keratin filament] evidence: IDA
            GeneID:3875 -> Cellular component: GO:0048471 [perinuclear region of cytoplasm] evidence: IEA

by @meso_cacase at DBCLS
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