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2024-04-20 23:52:07, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_182796 2293 bp mRNA linear PRI 01-JUL-2013
DEFINITION Homo sapiens methionine adenosyltransferase II, beta (MAT2B),
transcript variant 2, mRNA.
ACCESSION NM_182796
VERSION NM_182796.2 GI:422010900
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2293)
AUTHORS Shafqat,N., Muniz,J.R., Pilka,E.S., Papagrigoriou,E., von Delft,F.,
Oppermann,U. and Yue,W.W.
TITLE Insight into S-adenosylmethionine biosynthesis from the crystal
structures of the human methionine adenosyltransferase catalytic
and regulatory subunits
JOURNAL Biochem. J. 452 (1), 27-36 (2013)
PUBMED 23425511
REMARK GeneRIF: The structure of MAT2B reveals a short-chain
dehydrogenase/reductase (SDR) core with specificity for the NADP/H
cofactor, and harbors the SDR catalytic triad.
REFERENCE 2 (bases 1 to 2293)
AUTHORS Nordgren,K.K., Peng,Y., Pelleymounter,L.L., Moon,I., Abo,R.,
Feng,Q., Eckloff,B., Yee,V.C., Wieben,E. and Weinshilboum,R.M.
TITLE Methionine adenosyltransferase 2A/2B and methylation: gene sequence
variation and functional genomics
JOURNAL Drug Metab. Dispos. 39 (11), 2135-2147 (2011)
PUBMED 21813468
REMARK GeneRIF: Coexpression of MAT2A and MAT2B in COS-1 cells resulted in
significantly increased MAT enzyme activity.
REFERENCE 3 (bases 1 to 2293)
AUTHORS Xia,M., Chen,Y., Wang,L.C., Zandi,E., Yang,H., Bemanian,S.,
Martinez-Chantar,M.L., Mato,J.M. and Lu,S.C.
TITLE Novel function and intracellular localization of methionine
adenosyltransferase 2beta splicing variants
JOURNAL J. Biol. Chem. 285 (26), 20015-20021 (2010)
PUBMED 20421296
REMARK GeneRIF: Data show MAT2beta variants reside mostly in the nucleus
and regulate HuR subcellular content to affect cell proliferation.
REFERENCE 4 (bases 1 to 2293)
AUTHORS Attia,R.R., Gardner,L.A., Mahrous,E., Taxman,D.J., Legros,L.,
Rowe,S., Ting,J.P., Geller,A. and Kotb,M.
TITLE Selective targeting of leukemic cell growth in vivo and in vitro
using a gene silencing approach to diminish S-adenosylmethionine
synthesis
JOURNAL J. Biol. Chem. 283 (45), 30788-30795 (2008)
PUBMED 18753136
REMARK GeneRIF: differences in malignant cell survival, effected by
MAT-IIbeta ablation, suggest that it may be possible to use this
approach to disadvantage leukemic cell survival in vivo with little
to no harm to normal cells.
REFERENCE 5 (bases 1 to 2293)
AUTHORS Wang,Q., Liu,Q.Y., Liu,Z.S., Qian,Q., Sun,Q. and Pan,D.Y.
TITLE Lentivirus mediated shRNA interference targeting MAT2B induces
growth-inhibition and apoptosis in hepatocelluar carcinoma
JOURNAL World J. Gastroenterol. 14 (29), 4633-4642 (2008)
PUBMED 18698677
REMARK GeneRIF: a switch in MAT expression in liver cancer was accompanied
by increasing expression of MAT2B
REFERENCE 6 (bases 1 to 2293)
AUTHORS Martinez-Chantar,M.L., Garcia-Trevijano,E.R., Latasa,M.U.,
Martin-Duce,A., Fortes,P., Caballeria,J., Avila,M.A. and Mato,J.M.
TITLE Methionine adenosyltransferase II beta subunit gene expression
provides a proliferative advantage in human hepatoma
JOURNAL Gastroenterology 124 (4), 940-948 (2003)
PUBMED 12671891
REFERENCE 7 (bases 1 to 2293)
AUTHORS LeGros,L., Halim,A.B., Chamberlin,M.E., Geller,A. and Kotb,M.
TITLE Regulation of the human MAT2B gene encoding the regulatory beta
subunit of methionine adenosyltransferase, MAT II
JOURNAL J. Biol. Chem. 276 (27), 24918-24924 (2001)
PUBMED 11337507
REFERENCE 8 (bases 1 to 2293)
AUTHORS LeGros,H.L. Jr., Halim,A.B., Geller,A.M. and Kotb,M.
TITLE Cloning, expression, and functional characterization of the beta
regulatory subunit of human methionine adenosyltransferase (MAT II)
JOURNAL J. Biol. Chem. 275 (4), 2359-2366 (2000)
PUBMED 10644686
REFERENCE 9 (bases 1 to 2293)
AUTHORS Kotb,M., Mudd,S.H., Mato,J.M., Geller,A.M., Kredich,N.M., Chou,J.Y.
and Cantoni,G.L.
TITLE Consensus nomenclature for the mammalian methionine
adenosyltransferase genes and gene products
JOURNAL Trends Genet. 13 (2), 51-52 (1997)
PUBMED 9055605
REFERENCE 10 (bases 1 to 2293)
AUTHORS Okada,G., Teraoka,H. and Tsukada,K.
TITLE Multiple species of mammalian S-adenosylmethionine synthetase.
Partial purification and characterization
JOURNAL Biochemistry 20 (4), 934-940 (1981)
PUBMED 7213623
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from HY091756.1, AY358695.1,
AK096178.1 and HY366761.1.
On Nov 20, 2012 this sequence version replaced gi:33519454.
Summary: The protein encoded by this gene belongs to the methionine
adenosyltransferase (MAT) family. MAT catalyzes the biosynthesis of
S-adenosylmethionine from methionine and ATP. This protein is the
regulatory beta subunit of MAT. Alternative splicing results in
multiple transcript variants encoding different isoforms. [provided
by RefSeq, Nov 2012].
Transcript Variant: This variant (2) differs in the 5' UTR and 5'
coding region but maintains the reading frame, compared to variant
1. These differences result in a shorter isoform (2) with a
distinct N-terminus, compared to isoform 1.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: AY358695.1, AJ243721.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025082, ERS025083 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: full length.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-245 HY091756.1 2-246
246-1332 AY358695.1 1-1087
1333-2089 AK096178.1 2454-3210
2090-2293 HY366761.1 1-204 c
FEATURES Location/Qualifiers
source 1..2293
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="5"
/map="5q34-q35"
gene 1..2293
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/note="methionine adenosyltransferase II, beta"
/db_xref="GeneID:27430"
/db_xref="HGNC:6905"
/db_xref="MIM:605527"
exon 1..361
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/inference="alignment:Splign:1.39.8"
variation 36
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/replace="a"
/replace="c"
/db_xref="dbSNP:113109437"
variation 47
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/replace="g"
/replace="t"
/db_xref="dbSNP:377480475"
variation 48
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/replace="c"
/replace="t"
/db_xref="dbSNP:111676997"
variation 120
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/replace="c"
/replace="g"
/db_xref="dbSNP:182400121"
variation 199
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/replace="a"
/replace="g"
/db_xref="dbSNP:78101431"
variation 218
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/replace="g"
/replace="t"
/db_xref="dbSNP:75230624"
variation 230
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/replace="a"
/replace="g"
/db_xref="dbSNP:186816331"
variation 258
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/replace="a"
/replace="g"
/db_xref="dbSNP:112279650"
variation 289
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/replace="a"
/replace="g"
/db_xref="dbSNP:369376244"
variation 293
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/replace="c"
/replace="g"
/replace="t"
/db_xref="dbSNP:202024158"
variation 301
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/replace="c"
/replace="g"
/replace="t"
/db_xref="dbSNP:190145161"
misc_feature 314..316
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/note="upstream in-frame stop codon"
variation 329
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/replace="a"
/replace="g"
/db_xref="dbSNP:80167081"
CDS 332..1303
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/EC_number="2.5.1.6"
/note="isoform 2 is encoded by transcript variant 2; beta
regulatory subunit of methionine adenosyltransferase;
short chain dehydrogenase/reductase family 23E, member 1;
dTDP-4-keto-6-deoxy-D-glucose 4-reductase; methionine
adenosyltransferase 2 subunit beta; putative protein
product of Nbla02999; MAT II beta; putative
dTDP-4-keto-6-deoxy-D-glucose 4-reductase"
/codon_start=1
/product="methionine adenosyltransferase 2 subunit beta
isoform 2"
/protein_id="NP_877725.1"
/db_xref="GI:33519455"
/db_xref="CCDS:CCDS4364.1"
/db_xref="GeneID:27430"
/db_xref="HGNC:6905"
/db_xref="MIM:605527"
/translation="
MPEMPEDMEQEEVNIPNRRVLVTGATGLLGRAVHKEFQQNNWHAVGCGFRRARPKFEQVNLLDSNAVHHIIHDFQPHVIVHCAAERRPDVVENQPDAASQLNVDASGNLAKEAAAVGAFLIYISSDYVFDGTNPPYREEDIPAPLNLYGKTKLDGEKAVLENNLGAAVLRIPILYGEVEKLEESAVTVMFDKVQFSNKSANMDHWQQRFPTHVKDVATVCRQLAEKRMLDPSIKGTFHWSGNEQMTKYEMACAIADAFNLPSSHLRPITDSPVLGAQRPRNAQLDCSKLETLGIGQRTPFRIGIKESLWPFLIDKRWRQTVFH
"
misc_feature 386..1246
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/note="dTDP-6-deoxy-L-lyxo-4-hexulose reductase and
related proteins, extended (e) SDRs; Region:
dTDP_HR_like_SDR_e; cd05254"
/db_xref="CDD:187564"
misc_feature 389..1267
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/note="RmlD substrate binding domain; Region:
RmlD_sub_bind; pfam04321"
/db_xref="CDD:113104"
misc_feature order(401..403,407..418,473..478,506..517,575..583,
587..589,632..634,698..706,773..775,785..787,842..853)
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/note="NADP binding site [chemical binding]; other site"
/db_xref="CDD:187564"
misc_feature order(635..637,704..706,773..775,785..787)
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/note="active site"
/db_xref="CDD:187564"
misc_feature order(704..706,773..775,848..850,896..898,935..937,
953..955)
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/note="putative substrate binding site [chemical binding];
other site"
/db_xref="CDD:187564"
variation 350
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/replace="c"
/replace="g"
/db_xref="dbSNP:377672043"
variation 352
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/replace="c"
/replace="t"
/db_xref="dbSNP:369493873"
variation 359
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/replace="a"
/replace="c"
/db_xref="dbSNP:79684213"
exon 362..556
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/inference="alignment:Splign:1.39.8"
STS 376..492
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/standard_name="D5S1942"
/db_xref="UniSTS:154273"
variation 380
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/replace="a"
/replace="t"
/db_xref="dbSNP:370620878"
variation 412
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/replace="a"
/replace="g"
/db_xref="dbSNP:375538961"
variation 426
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/replace="c"
/replace="t"
/db_xref="dbSNP:376756318"
variation 446
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/replace="c"
/replace="g"
/db_xref="dbSNP:148822569"
variation 459
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/replace="a"
/replace="t"
/db_xref="dbSNP:369618222"
variation 526
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/replace="c"
/replace="t"
/db_xref="dbSNP:186526604"
variation 529
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/replace="a"
/replace="g"
/db_xref="dbSNP:143459228"
variation 545
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/replace="a"
/replace="c"
/db_xref="dbSNP:201956239"
variation 550
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/replace="c"
/replace="t"
/db_xref="dbSNP:370330528"
exon 557..671
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/inference="alignment:Splign:1.39.8"
variation 559
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/replace="a"
/replace="c"
/db_xref="dbSNP:148055585"
variation 631
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/replace="a"
/replace="g"
/db_xref="dbSNP:113548741"
variation 661
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/replace="a"
/replace="t"
/db_xref="dbSNP:141130487"
exon 672..824
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/inference="alignment:Splign:1.39.8"
variation 676
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/replace="c"
/replace="t"
/db_xref="dbSNP:144747113"
variation 677
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/replace="a"
/replace="g"
/db_xref="dbSNP:201068474"
variation 727
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/replace="a"
/replace="c"
/db_xref="dbSNP:372864990"
variation 728
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/replace="a"
/replace="g"
/db_xref="dbSNP:138673581"
variation 766
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/replace="a"
/replace="g"
/db_xref="dbSNP:375829232"
variation 783
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/replace="c"
/replace="t"
/db_xref="dbSNP:150850594"
variation 805
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/replace="c"
/replace="t"
/db_xref="dbSNP:183216928"
variation 823
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/replace="a"
/replace="g"
/db_xref="dbSNP:11546512"
exon 825..1018
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/inference="alignment:Splign:1.39.8"
variation 827
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/replace="g"
/replace="t"
/db_xref="dbSNP:185174859"
variation 832
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/replace="c"
/replace="t"
/db_xref="dbSNP:371182015"
variation 853
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/replace="g"
/replace="t"
/db_xref="dbSNP:375446953"
variation 869
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/replace="a"
/replace="t"
/db_xref="dbSNP:57377425"
variation 875
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/replace="a"
/replace="g"
/db_xref="dbSNP:200525612"
variation 884
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/replace="c"
/replace="g"
/db_xref="dbSNP:201528924"
variation 897
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/replace="c"
/replace="t"
/db_xref="dbSNP:367745735"
variation 936
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/replace="c"
/replace="t"
/db_xref="dbSNP:149558527"
variation 951
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/replace="a"
/replace="g"
/db_xref="dbSNP:144243962"
variation 967
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/replace="c"
/replace="t"
/db_xref="dbSNP:201730499"
variation 991
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/replace="c"
/replace="t"
/db_xref="dbSNP:199601793"
exon 1019..1132
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/inference="alignment:Splign:1.39.8"
variation 1028
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/replace="a"
/replace="g"
/db_xref="dbSNP:369683567"
variation 1043
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/replace="a"
/replace="c"
/db_xref="dbSNP:373467119"
variation 1056
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/replace="a"
/replace="g"
/db_xref="dbSNP:140996665"
variation 1064
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/replace="a"
/replace="g"
/db_xref="dbSNP:368945288"
variation 1084
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/replace="a"
/replace="t"
/db_xref="dbSNP:372671147"
variation 1103
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/replace="g"
/replace="t"
/db_xref="dbSNP:200867979"
variation 1112
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/replace="c"
/replace="t"
/db_xref="dbSNP:77428501"
exon 1133..2293
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/inference="alignment:Splign:1.39.8"
variation 1134
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/replace="g"
/replace="t"
/db_xref="dbSNP:201204381"
variation 1136
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/replace="a"
/replace="g"
/db_xref="dbSNP:376794098"
variation 1151
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/replace="c"
/replace="g"
/replace="t"
/db_xref="dbSNP:77437261"
variation 1162
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/replace="a"
/replace="g"
/db_xref="dbSNP:187556859"
variation 1164
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/replace="a"
/replace="g"
/db_xref="dbSNP:147499303"
variation 1168
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/replace="a"
/replace="g"
/db_xref="dbSNP:140070929"
variation 1175
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/replace="a"
/replace="g"
/db_xref="dbSNP:17849948"
variation 1203
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/replace="c"
/replace="t"
/db_xref="dbSNP:80145956"
variation 1235
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/replace="a"
/replace="t"
/db_xref="dbSNP:368383130"
variation 1261
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/replace="a"
/replace="t"
/db_xref="dbSNP:199689662"
variation 1269
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/replace="c"
/replace="t"
/db_xref="dbSNP:192771488"
variation 1304..1307
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/replace=""
/replace="ttta"
/db_xref="dbSNP:376171593"
variation 1322
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/replace=""
/replace="t"
/db_xref="dbSNP:200442777"
variation 1343
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/replace="a"
/replace="g"
/db_xref="dbSNP:201566984"
variation 1355
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/replace="a"
/replace="g"
/db_xref="dbSNP:376358346"
variation 1363
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/replace=""
/replace="t"
/db_xref="dbSNP:35274545"
variation 1408
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/replace="c"
/replace="t"
/db_xref="dbSNP:182987686"
variation 1444
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/replace="a"
/replace="g"
/db_xref="dbSNP:188430776"
variation 1482..1483
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/replace=""
/replace="c"
/db_xref="dbSNP:35541788"
variation 1544
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/replace="a"
/replace="g"
/db_xref="dbSNP:191819378"
variation 1578
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/replace="c"
/replace="t"
/db_xref="dbSNP:11546511"
STS 1714..1902
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/standard_name="RH93678"
/db_xref="UniSTS:89867"
STS 1875..1995
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/standard_name="STS-D25599"
/db_xref="UniSTS:73833"
variation 1894
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/replace="c"
/replace="t"
/db_xref="dbSNP:372905622"
variation 1903
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/replace="a"
/replace="g"
/db_xref="dbSNP:141380012"
variation 2001
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/replace="c"
/replace="t"
/db_xref="dbSNP:184421743"
variation 2005
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/replace="a"
/replace="t"
/db_xref="dbSNP:143399168"
variation 2218
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/replace="a"
/replace="t"
/db_xref="dbSNP:189130444"
variation 2245..2249
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/replace=""
/replace="aaaac"
/db_xref="dbSNP:150449376"
variation 2246
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/replace="a"
/replace="c"
/db_xref="dbSNP:200172118"
variation 2249
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/replace="c"
/replace="t"
/db_xref="dbSNP:200926033"
variation 2250
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/replace="a"
/replace="c"
/db_xref="dbSNP:1129940"
polyA_signal 2252..2257
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
variation 2274
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/replace="c"
/replace="g"
/db_xref="dbSNP:192468905"
polyA_site 2276
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/note="The 3' most polyA site has not been determined.
This is a major internal polyA site."
ORIGIN
gggtttttgtttttgtttttgttaagtagttagttctaccaaatagttttgcaaatagacccaggcttgactggcaattaaacatgaaacttctcattgggtattttcgagactactacggggaatcagctaccagcttactgccatgtggagaactgcacgagattccgggattggaatcaaaatgctaatttaaaaggtcaagtgaagctgctcctcacgttttggcgtgcctgcgctctctgcaggcagaagcgaacaaagacccagcaagagaaggcagaggctaagacccatcccgtatctgctctcctgaaataattctggagtcatgcctgaaatgccagaggacatggagcaggaggaagttaacatccctaataggagggttctggttactggtgccactgggcttcttggcagagctgtacacaaagaatttcagcagaataattggcatgcagttggctgtggtttcagaagagcaagaccaaaatttgaacaggttaatctgttggattctaatgcagttcatcacatcattcatgattttcagccccatgttatagtacattgtgcagcagagagaagaccagatgttgtagaaaatcagccagatgctgcctctcaacttaatgtggatgcttctgggaatttagcaaaggaagcagctgctgttggagcatttctcatctacattagctcagattatgtatttgatggaacaaatccaccttacagagaggaagacataccagctcccctaaatttgtatggcaaaacaaaattagatggagaaaaggctgtcctggagaacaatctaggagctgctgttttgaggattcctattctgtatggggaagttgaaaagctcgaagaaagtgctgtgactgttatgtttgataaagtgcagttcagcaacaagtcagcaaacatggatcactggcagcagaggttccccacacatgtcaaagatgtggccactgtgtgccggcagctagcagagaagagaatgctggatccatcaattaagggaacctttcactggtctggcaatgaacagatgactaagtatgaaatggcatgtgcaattgcagatgccttcaacctccccagcagtcacttaagacctattactgacagccctgtcctaggagcacaacgtccgagaaatgctcagcttgactgctccaaattggagaccttgggcattggccaacgaacaccatttcgaattggaatcaaagaatcactttggcctttcctcattgacaagagatggagacaaacggtctttcattagtttatttgtgttgggttcttttttttttttaaatgaaaagtatagtatgtggcactttttaaagaacaaaggaaatagttttgtatgagtactttaattgtgactcttaggatctttcaggtaaatgatgctcttgcactagtgaaattgtctaaagaaactaaagggcagtcatgccctgtttgcagtaatttttctttttatcattttgtttgtcctggctaaacttggagtttgagtatagtaaattatgatccttaaatatttgagagtcaggatgaagcagatctgctgtagacttttcagatgaaattgttcattctcgtaacctccatattttcaggatttttgaagctgttgaccttttcatgttgattattttaaattgtgtgaaatagtataaaaatcattggtgttcattatttgctttgcctgagctcagatcaaaatgtttgaagaaaggaactttatttttgcaagttacgtacagtttttatgcttgagatatttcaacatgttatgtatattggaacttctacagcttgatgcctcctgcttttatagcagtttatggggagcacttgaaagagcgtgtgtacatgtattttttttctaggcaaacattgaatgcaaacgtgtatttttttaatataaatatataactgtccttttcatcccatgttgccgctaagtgatatttcatatgtgtggttatactcataataatgggccttgtaagtcttttcaccattcatgaataataataaatatgtactgctggcatgtaatgcttagttttcttgtatttacttctttttttaaatgtaaggaccaaacttctaaactaattgttcttttgttgctttaatttttaaaaattacattcttctgatgtaacatgtgatacatacaaaagaatatagtttaatatgtattgaaataaaacacaataaaattaacacttgatccagaatgttaacttaccacccc
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:27430 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:27430 -> Molecular function: GO:0008831 [dTDP-4-dehydrorhamnose reductase activity] evidence: IEA
GeneID:27430 -> Molecular function: GO:0048270 [methionine adenosyltransferase regulator activity] evidence: IDA
GeneID:27430 -> Biological process: GO:0000096 [sulfur amino acid metabolic process] evidence: TAS
GeneID:27430 -> Biological process: GO:0006556 [S-adenosylmethionine biosynthetic process] evidence: IDA
GeneID:27430 -> Biological process: GO:0006556 [S-adenosylmethionine biosynthetic process] evidence: IEA
GeneID:27430 -> Biological process: GO:0006730 [one-carbon metabolic process] evidence: IEA
GeneID:27430 -> Biological process: GO:0006805 [xenobiotic metabolic process] evidence: TAS
GeneID:27430 -> Biological process: GO:0032259 [methylation] evidence: TAS
GeneID:27430 -> Biological process: GO:0034641 [cellular nitrogen compound metabolic process] evidence: TAS
GeneID:27430 -> Biological process: GO:0044281 [small molecule metabolic process] evidence: TAS
GeneID:27430 -> Biological process: GO:0045226 [extracellular polysaccharide biosynthetic process] evidence: IEA
GeneID:27430 -> Cellular component: GO:0005622 [intracellular] evidence: IC
GeneID:27430 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
GeneID:27430 -> Cellular component: GO:0005739 [mitochondrion] evidence: IEA
GeneID:27430 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
GeneID:27430 -> Cellular component: GO:0048269 [methionine adenosyltransferase complex] evidence: IDA
ANNOTATIONS from NCBI Entrez Gene (20130726):
NP_877725 -> EC 2.5.1.6
by
@meso_cacase at
DBCLS
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