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2024-04-26 07:31:16, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_178432 2382 bp mRNA linear PRI 17-APR-2013
DEFINITION Homo sapiens cyclin-dependent kinase 20 (CDK20), transcript variant
1, mRNA.
ACCESSION NM_178432
VERSION NM_178432.3 GI:282402172
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2382)
AUTHORS Mumert,M., Dubuc,A., Wu,X., Northcott,P.A., Chin,S.S., Pedone,C.A.,
Taylor,M.D. and Fults,D.W.
TITLE Functional genomics identifies drivers of medulloblastoma
dissemination
JOURNAL Cancer Res. 72 (19), 4944-4953 (2012)
PUBMED 22875024
REMARK GeneRIF: Data indicate that expression of ERAS, LHX1, and CCRK is
increased in aggressive subgroups of medulloblastomas.
REFERENCE 2 (bases 1 to 2382)
AUTHORS Feng,H., Cheng,A.S., Tsang,D.P., Li,M.S., Go,M.Y., Cheung,Y.S.,
Zhao,G.J., Ng,S.S., Lin,M.C., Yu,J., Lai,P.B., To,K.F. and
Sung,J.J.
TITLE Cell cycle-related kinase is a direct androgen receptor-regulated
gene that drives beta-catenin/T cell factor-dependent
hepatocarcinogenesis
JOURNAL J. Clin. Invest. 121 (8), 3159-3175 (2011)
PUBMED 21747169
REMARK GeneRIF: Cell cycle-related kinase is a direct androgen
receptor-regulated gene that drives beta-catenin/T cell
factor-dependent hepatocarcinogenesis
REFERENCE 3 (bases 1 to 2382)
AUTHORS An,X., Ng,S.S., Xie,D., Zeng,Y.X., Sze,J., Wang,J., Chen,Y.C.,
Chow,B.K., Lu,G., Poon,W.S., Kung,H.F., Wong,B.C. and Lin,M.C.
TITLE Functional characterisation of cell cycle-related kinase (CCRK) in
colorectal cancer carcinogenesis
JOURNAL Eur. J. Cancer 46 (9), 1752-1761 (2010)
PUBMED 20466538
REMARK GeneRIF: results suggest for the first time that CCRK is involved
in colorectal cancer carcinogenesis and G1/S cell cycle transition
by regulating Cdk2, cyclin E and Rb.
REFERENCE 4 (bases 1 to 2382)
AUTHORS Wu,G.Q., Xie,D., Yang,G.F., Liao,Y.J., Mai,S.J., Deng,H.X., Sze,J.,
Guan,X.Y., Zeng,Y.X., Lin,M.C. and Kung,H.F.
TITLE Cell cycle-related kinase supports ovarian carcinoma cell
proliferation via regulation of cyclin D1 and is a predictor of
outcome in patients with ovarian carcinoma
JOURNAL Int. J. Cancer 125 (11), 2631-2642 (2009)
PUBMED 19672860
REMARK GeneRIF: Overexpression of CCRK is associated with ovarian
carcinoma.
REFERENCE 5 (bases 1 to 2382)
AUTHORS Malumbres,M., Harlow,E., Hunt,T., Hunter,T., Lahti,J.M.,
Manning,G., Morgan,D.O., Tsai,L.H. and Wolgemuth,D.J.
TITLE Cyclin-dependent kinases: a family portrait
JOURNAL Nat. Cell Biol. 11 (11), 1275-1276 (2009)
PUBMED 19884882
REFERENCE 6 (bases 1 to 2382)
AUTHORS Qiu,H., Dai,H., Jain,K., Shah,R., Hong,C., Pain,J., Tian,B.,
Vatner,D.E., Vatner,S.F. and Depre,C.
TITLE Characterization of a novel cardiac isoform of the cell
cycle-related kinase that is regulated during heart failure
JOURNAL J. Biol. Chem. 283 (32), 22157-22165 (2008)
PUBMED 18508765
REFERENCE 7 (bases 1 to 2382)
AUTHORS Wohlbold,L., Larochelle,S., Liao,J.C., Livshits,G., Singer,J.,
Shokat,K.M. and Fisher,R.P.
TITLE The cyclin-dependent kinase (CDK) family member PNQALRE/CCRK
supports cell proliferation but has no intrinsic CDK-activating
kinase (CAK) activity
JOURNAL Cell Cycle 5 (5), 546-554 (2006)
PUBMED 16552187
REMARK GeneRIF: Depletion of PNQALRE by >80% due to RNA interference
(RNAi) impairs cell proliferation, but fails to arrest the cell
cycle at a discrete point.
REFERENCE 8 (bases 1 to 2382)
AUTHORS Liu,Y., Wu,C. and Galaktionov,K.
TITLE p42, a novel cyclin-dependent kinase-activating kinase in mammalian
cells
JOURNAL J. Biol. Chem. 279 (6), 4507-4514 (2004)
PUBMED 14597612
REMARK GeneRIF: identification of p42, a novel cyclin-dependent
kinase-activating kinase (CAK) activity in human cells; p42 is
essential for the phosphorylation of Thr-160 and activation of CDK2
and is indispensable for cell growth
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from DB469301.1, CB992644.1,
AK075325.1, AY904367.1, AL353572.13, AI479563.1 and BM982394.1.
On Dec 30, 2009 this sequence version replaced gi:89903015.
Summary: The protein encoded by this gene contains a kinase domain
most closely related to the cyclin-dependent protein kinases. The
encoded kinase may activate cyclin-dependent kinase 2 and is
involved in cell growth. Alternatively spliced transcript variants
encoding distinct isoforms have been reported. [provided by RefSeq,
Dec 2009].
Transcript Variant: This variant (1) encodes isoform 1.
##Evidence-Data-START##
Transcript exon combination :: AK075325.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025084 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-18 DB469301.1 1-18
19-280 CB992644.1 28-289
281-495 AK075325.1 34-248
496-496 AY904367.1 123-123
497-1582 AK075325.1 250-1335
1583-2179 AL353572.13 64637-65233 c
2180-2367 AI479563.1 1-188 c
2368-2382 BM982394.1 2-16 c
FEATURES Location/Qualifiers
source 1..2382
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="9"
/map="9q22.1"
gene 1..2382
/gene="CDK20"
/gene_synonym="CCRK; CDCH; P42; PNQALRE"
/note="cyclin-dependent kinase 20"
/db_xref="GeneID:23552"
/db_xref="HGNC:21420"
/db_xref="MIM:610076"
exon 1..409
/gene="CDK20"
/gene_synonym="CCRK; CDCH; P42; PNQALRE"
/inference="alignment:Splign:1.39.8"
variation 108
/gene="CDK20"
/gene_synonym="CCRK; CDCH; P42; PNQALRE"
/replace="c"
/replace="g"
/db_xref="dbSNP:28364934"
misc_feature 188..190
/gene="CDK20"
/gene_synonym="CCRK; CDCH; P42; PNQALRE"
/note="upstream in-frame stop codon"
CDS 335..1351
/gene="CDK20"
/gene_synonym="CCRK; CDCH; P42; PNQALRE"
/EC_number="2.7.11.22"
/note="isoform 1 is encoded by transcript variant 1; cell
division protein kinase 20; CAK-kinase p42; CDK-activating
kinase p42; cyclin-kinase-activating kinase p42;
cyclin-dependent protein kinase H; cell cycle-related
kinase"
/codon_start=1
/product="cyclin-dependent kinase 20 isoform 1"
/protein_id="NP_848519.1"
/db_xref="GI:30795255"
/db_xref="CCDS:CCDS6678.1"
/db_xref="GeneID:23552"
/db_xref="HGNC:21420"
/db_xref="MIM:610076"
/translation="
MDQYCILGRIGEGAHGIVFKAKHVEPRVGWQCLPSILQTGEIVALKKVALRRLEDGFPNQALREIKALQEMEDNQYVVQLKAVFPHGGGFVLAFEFMLSDLAEVVRHAQRPLAQAQVKSYLQMLLKGVAFCHANNIVHRDLKPANLLISASGQLKIADFGLARVFSPDGSRLYTHQVATRSVGCIMGELLNGSPLFPGKNDIEQLCYVLRILGTPNPQVWPELTELPDYNKISFKEQVPMPLEEVLPDVSPQALDLLGQFLLYPPHQRIAASKALLHQYFFTAPLPAHPSELPIPQRLGGPAPKAHPGPPHIHDFHVDRPLEESLLNPELIRPFILEG
"
misc_feature 335..1174
/gene="CDK20"
/gene_synonym="CCRK; CDCH; P42; PNQALRE"
/note="cyclin-dependent kinase A; Provisional; Region:
PLN00009"
/db_xref="CDD:177649"
misc_feature 341..1177
/gene="CDK20"
/gene_synonym="CCRK; CDCH; P42; PNQALRE"
/note="Catalytic domain of the Serine/Threonine Kinase,
Cell Cycle-Related Kinase; Region: STKc_CCRK; cd07832"
/db_xref="CDD:173736"
misc_feature order(362..373,386..388,464..466,470..472,521..523,
566..568,614..625,632..634,638..643,752..754,758..760,
764..769,773..775,806..808,815..817,854..856,860..871,
926..928)
/gene="CDK20"
/gene_synonym="CCRK; CDCH; P42; PNQALRE"
/note="active site"
/db_xref="CDD:173736"
misc_feature order(362..373,386..388,464..466,470..472,566..568,
614..625,632..634,641..643,764..769,773..775,806..808)
/gene="CDK20"
/gene_synonym="CCRK; CDCH; P42; PNQALRE"
/note="ATP binding site [chemical binding]; other site"
/db_xref="CDD:173736"
misc_feature order(521..523,638..640,752..754,758..760,815..817,
854..856,860..871,926..928)
/gene="CDK20"
/gene_synonym="CCRK; CDCH; P42; PNQALRE"
/note="substrate binding site [chemical binding]; other
site"
/db_xref="CDD:173736"
misc_feature order(803..838,851..874)
/gene="CDK20"
/gene_synonym="CCRK; CDCH; P42; PNQALRE"
/note="activation loop (A-loop); other site"
/db_xref="CDD:173736"
exon 410..562
/gene="CDK20"
/gene_synonym="CCRK; CDCH; P42; PNQALRE"
/inference="alignment:Splign:1.39.8"
variation 429
/gene="CDK20"
/gene_synonym="CCRK; CDCH; P42; PNQALRE"
/replace="g"
/replace="t"
/db_xref="dbSNP:28364935"
exon 563..751
/gene="CDK20"
/gene_synonym="CCRK; CDCH; P42; PNQALRE"
/inference="alignment:Splign:1.39.8"
variation 630
/gene="CDK20"
/gene_synonym="CCRK; CDCH; P42; PNQALRE"
/replace="c"
/replace="t"
/db_xref="dbSNP:28364953"
variation 658
/gene="CDK20"
/gene_synonym="CCRK; CDCH; P42; PNQALRE"
/replace="a"
/replace="c"
/db_xref="dbSNP:3750491"
exon 752..873
/gene="CDK20"
/gene_synonym="CCRK; CDCH; P42; PNQALRE"
/inference="alignment:Splign:1.39.8"
variation 782
/gene="CDK20"
/gene_synonym="CCRK; CDCH; P42; PNQALRE"
/replace="a"
/replace="g"
/db_xref="dbSNP:28364955"
exon 874..997
/gene="CDK20"
/gene_synonym="CCRK; CDCH; P42; PNQALRE"
/inference="alignment:Splign:1.39.8"
variation 925
/gene="CDK20"
/gene_synonym="CCRK; CDCH; P42; PNQALRE"
/replace="a"
/replace="g"
/db_xref="dbSNP:28364959"
exon 998..1153
/gene="CDK20"
/gene_synonym="CCRK; CDCH; P42; PNQALRE"
/inference="alignment:Splign:1.39.8"
variation 1152
/gene="CDK20"
/gene_synonym="CCRK; CDCH; P42; PNQALRE"
/replace="a"
/replace="g"
/db_xref="dbSNP:28364963"
exon 1154..2372
/gene="CDK20"
/gene_synonym="CCRK; CDCH; P42; PNQALRE"
/inference="alignment:Splign:1.39.8"
variation 1504
/gene="CDK20"
/gene_synonym="CCRK; CDCH; P42; PNQALRE"
/replace="c"
/replace="t"
/db_xref="dbSNP:3750492"
variation 1793
/gene="CDK20"
/gene_synonym="CCRK; CDCH; P42; PNQALRE"
/replace="a"
/replace="g"
/db_xref="dbSNP:28364970"
STS 1941..2089
/gene="CDK20"
/gene_synonym="CCRK; CDCH; P42; PNQALRE"
/standard_name="WIAF-2079"
/db_xref="UniSTS:8848"
STS 1989..2154
/gene="CDK20"
/gene_synonym="CCRK; CDCH; P42; PNQALRE"
/standard_name="A005E17"
/db_xref="UniSTS:40615"
variation 2156
/gene="CDK20"
/gene_synonym="CCRK; CDCH; P42; PNQALRE"
/replace="a"
/replace="g"
/db_xref="dbSNP:28364971"
polyA_signal 2181..2186
/gene="CDK20"
/gene_synonym="CCRK; CDCH; P42; PNQALRE"
polyA_site 2202
/gene="CDK20"
/gene_synonym="CCRK; CDCH; P42; PNQALRE"
polyA_signal 2339..2344
/gene="CDK20"
/gene_synonym="CCRK; CDCH; P42; PNQALRE"
polyA_site 2372
/gene="CDK20"
/gene_synonym="CCRK; CDCH; P42; PNQALRE"
ORIGIN
gggggcgggggcagataggaggtgcctgctgtcatcgttccgtgggccctgctgcgggcacgctctcggcgcatgcgttttttatgcgggattaagcttgctgctgcgtgacagcggagggctaggaaaaggcgcagtggggcccggagctgtcacccctgactcgacgcagcttccgttctcctggtgacgtcgcctacaggaaccgccccagtggtcagctgccgcgctgttgctaggcaacagcgtgcgagctcagatcagcgtggggtggaggagaagtggagtttggaagttcaggggcacaggggcacaggcccacgactgcagcgggatggaccagtactgcatcctgggccgcatcggggagggcgcccacggcatcgtcttcaaggccaagcacgtggagccgagggtgggctggcagtgtctgccttctatcctgcagactggcgagatagttgccctcaagaaggtggccctaaggcggttggaggacggcttccctaaccaggccctgcgggagattaaggctctgcaggagatggaggacaatcagtatgtggtacaactgaaggctgtgttcccacacggtggaggctttgtgctggcctttgagttcatgctgtcggatctggccgaggtggtgcgccatgcccagaggccactagcccaggcacaggtcaagagctacctgcagatgctgctcaagggtgtcgccttctgccatgccaacaacattgtacatcgggacctgaaacctgccaacctgctcatcagcgcctcaggccagctcaagatagcggactttggcctggctcgagtcttttccccagacggcagccgcctctacacacaccaggtggccaccaggtctgtgggctgcatcatgggggagctgttgaatgggtccccccttttcccgggcaagaacgatattgaacagctttgctatgtgcttcgcatcttgggcaccccaaaccctcaagtctggccggagctcactgagctgccggactacaacaagatctcctttaaggagcaggtgcccatgcccctggaggaggtgctgcctgacgtctctccccaggcattggatctgctgggtcaattccttctctaccctcctcaccagcgcatcgcagcttccaaggctctcctccatcagtacttcttcacagctcccctgcctgcccatccatctgagctgccgattcctcagcgtctagggggacctgcccccaaggcccatccagggcccccccacatccatgacttccacgtggaccggcctcttgaggagtcgctgttgaacccagagctgattcggcccttcatcctggaggggtgagaagttggccctggtcccgtctgcctgctcctcaggaccactcagtccacctgttcctctgccacctgcctggcttcaccctccaaggcctccccatggccacagtgggcccacaccacaccctgccccttagcccttgcgagggttggtctcgaggcagaggtcatgttcccagccaagagtatgagaacatccagtcgagcagaggagattcatggcctgtgctcggtgagccttaccttctgtgtgctactgacgtacccatcaggacagtgagctctgctgccagtcaaggcctgcatatgcagaatgacgatgcctgccttggtgctgcttccccgagtgctgcctcctggtcaaggagaagtgcagagagtaaggtgtccttatgttggaaactcaagtggaaggaagatttggtttggttttattctcagagccattaaacactagttcagtatgtgagatatagattctaaaaacctcaggtggctctgccttatgtctgttcctccttcatttctctcaagggaaatggctaaggtggcattgtctcatggctctcgtttttggggtcatggggagggtagcaccaggcatagccacttttgccctgagggactcctgtgtacttcacatcactgagcactcatttagaagtgagggagacagaagtctaggcccagggatggctccagttggggatccagcaggagaccctctgcacatgaggctggtttaccaacatctactccctcaggatgagcgtgagccagaagcagctgtgtatttaaggaaacaagcgttcctggaattaatttataaatttaataaatcccaatataatcccagctagtgctttttccttattataatttgataaggtgattataaaagatacatggaaggaagtggaaccagatgcagaagaggaaatgatggaaggacttacggtatcagataccaatatttaaaagtttgtataataataaagagtatgattgtggttcaaggataaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:23552 -> Molecular function: GO:0004693 [cyclin-dependent protein serine/threonine kinase activity] evidence: IEA
GeneID:23552 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:23552 -> Molecular function: GO:0005524 [ATP binding] evidence: IEA
GeneID:23552 -> Biological process: GO:0007275 [multicellular organismal development] evidence: IEA
GeneID:23552 -> Biological process: GO:0051301 [cell division] evidence: IEA
GeneID:23552 -> Cellular component: GO:0005634 [nucleus] evidence: IEA
GeneID:23552 -> Cellular component: GO:0005737 [cytoplasm] evidence: IEA
GeneID:23552 -> Cellular component: GO:0005929 [cilium] evidence: IEA
ANNOTATIONS from NCBI Entrez Gene (20130726):
NP_848519 -> EC 2.7.11.22
by
@meso_cacase at
DBCLS
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