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2024-03-28 23:37:33, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_177422               3409 bp    mRNA    linear   PRI 08-JUL-2013
DEFINITION  Homo sapiens argonaute RISC catalytic component 3 (AGO3),
            transcript variant 2, mRNA.
ACCESSION   NM_177422
VERSION     NM_177422.2  GI:324073531
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3409)
  AUTHORS   Hu,Q., Tanasa,B., Trabucchi,M., Li,W., Zhang,J., Ohgi,K.A.,
            Rose,D.W., Glass,C.K. and Rosenfeld,M.G.
  TITLE     DICER- and AGO3-dependent generation of retinoic acid-induced DR2
            Alu RNAs regulates human stem cell proliferation
  JOURNAL   Nat. Struct. Mol. Biol. 19 (11), 1168-1175 (2012)
   PUBMED   23064648
  REMARK    GeneRIF: DICER- and AGO3-dependent generation of retinoic
            acid-induced DR2 Alu RNAs regulates human stem cell proliferation.
REFERENCE   2  (bases 1 to 3409)
  AUTHORS   Wang,D., Zhang,Z., O'Loughlin,E., Lee,T., Houel,S., O'Carroll,D.,
            Tarakhovsky,A., Ahn,N.G. and Yi,R.
  TITLE     Quantitative functions of Argonaute proteins in mammalian
            development
  JOURNAL   Genes Dev. 26 (7), 693-704 (2012)
   PUBMED   22474261
  REMARK    GeneRIF: Ago3 is able to load microRNAs efficiently in the absence
            of Ago1 and Ago2, despite a significant loss of global microRNA
            expression
REFERENCE   3  (bases 1 to 3409)
  AUTHORS   Omel'ianchuk,N.A., Ponomarenko,P.M. and Ponomarenko,M.P.
  TITLE     [The nucleotide sequence features of the mature microRNA seem to be
            responsible for the affinity to human Ago2 AND Ago3 proteins]
  JOURNAL   Mol. Biol. (Mosk.) 45 (2), 366-375 (2011)
   PUBMED   21634124
  REMARK    GeneRIF: reliable predictions of miRNA affinity to Ago2 AND Ago3
            proteins were made.
REFERENCE   4  (bases 1 to 3409)
  AUTHORS   Potenza,N., Papa,U. and Russo,A.
  TITLE     Differential expression of Dicer and Argonaute genes during the
            differentiation of human neuroblastoma cells
  JOURNAL   Cell Biol. Int. 33 (7), 734-738 (2009)
   PUBMED   19393748
  REMARK    GeneRIF: EIF@C3 protein is expressed in both Schwann and
            neuron-type differentiating cells.
REFERENCE   5  (bases 1 to 3409)
  AUTHORS   Weinmann,L., Hock,J., Ivacevic,T., Ohrt,T., Mutze,J., Schwille,P.,
            Kremmer,E., Benes,V., Urlaub,H. and Meister,G.
  TITLE     Importin 8 is a gene silencing factor that targets argonaute
            proteins to distinct mRNAs
  JOURNAL   Cell 136 (3), 496-507 (2009)
   PUBMED   19167051
REFERENCE   6  (bases 1 to 3409)
  AUTHORS   Wu,L., Fan,J. and Belasco,J.G.
  TITLE     Importance of translation and nonnucleolytic ago proteins for
            on-target RNA interference
  JOURNAL   Curr. Biol. 18 (17), 1327-1332 (2008)
   PUBMED   18771919
  REMARK    GeneRIF: The specificity of RNA interference depends on the
            concentration of Ago1, Ago3, and Ago4 relative to Ago2.
REFERENCE   7  (bases 1 to 3409)
  AUTHORS   Sasaki,T., Shiohama,A., Minoshima,S. and Shimizu,N.
  TITLE     Identification of eight members of the Argonaute family in the
            human genome small star, filled
  JOURNAL   Genomics 82 (3), 323-330 (2003)
   PUBMED   12906857
REFERENCE   8  (bases 1 to 3409)
  AUTHORS   Doi,N., Zenno,S., Ueda,R., Ohki-Hamazaki,H., Ui-Tei,K. and Saigo,K.
  TITLE     Short-interfering-RNA-mediated gene silencing in mammalian cells
            requires Dicer and eIF2C translation initiation factors
  JOURNAL   Curr. Biol. 13 (1), 41-46 (2003)
   PUBMED   12526743
REFERENCE   9  (bases 1 to 3409)
  AUTHORS   Carmell,M.A., Xuan,Z., Zhang,M.Q. and Hannon,G.J.
  TITLE     The Argonaute family: tentacles that reach into RNAi, developmental
            control, stem cell maintenance, and tumorigenesis
  JOURNAL   Genes Dev. 16 (21), 2733-2742 (2002)
   PUBMED   12414724
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BF979526.1, BC025769.1,
            BX104163.1 and AA251146.1.
            On Feb 25, 2011 this sequence version replaced gi:29337285.
            
            Summary: This gene encodes a member of the Argonaute family of
            proteins which play a role in RNA interference. The encoded protein
            is highly basic, contains a PAZ domain and a PIWI domain, and may
            play a role in short-interfering-RNA-mediated gene silencing. This
            gene is located on chromosome 1 in a tandem cluster of closely
            related family members including argonaute 4 and eukaryotic
            translation initiation factor 2C, 1. Two transcript variants
            encoding distinct isoforms have been identified for this gene.
            [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (2) has multiple differences in
            the coding region, which causes translation initiation at a
            downstream start codon, compared to variant 1. The resulting
            protein (isoform b) has a shorter N-terminus than isoform a.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC025769.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           ERS025081, ERS025082 [ECO:0000350]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-176               BF979526.1         6-181
            177-3119            BC025769.1         1-2943
            3120-3175           BX104163.1         14-69               c
            3176-3409           AA251146.1         1-234               c
FEATURES             Location/Qualifiers
     source          1..3409
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p34"
     gene            1..3409
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /note="argonaute RISC catalytic component 3"
                     /db_xref="GeneID:192669"
                     /db_xref="HGNC:18421"
                     /db_xref="MIM:607355"
     exon            1..364
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /inference="alignment:Splign:1.39.8"
     variation       20
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:148583974"
     variation       107
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:368650571"
     variation       267
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:372333004"
     variation       294
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:376997221"
     variation       304
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:375614115"
     variation       332
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:367620032"
     variation       341
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:1137693"
     variation       364
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:371705852"
     exon            365..536
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /inference="alignment:Splign:1.39.8"
     variation       374
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:141269853"
     variation       382
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:139647049"
     variation       393
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:372140569"
     variation       397
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:147640766"
     variation       426
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:377039064"
     variation       485
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:369710801"
     exon            537..745
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /inference="alignment:Splign:1.39.8"
     variation       593
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:148843760"
     variation       653
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:370300022"
     variation       656
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:146858503"
     variation       662
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:189436392"
     variation       680
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:78625682"
     variation       711
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:145896554"
     variation       734
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:140942553"
     variation       735
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:374759763"
     misc_feature    742..744
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /note="upstream in-frame stop codon"
     exon            746..880
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /inference="alignment:Splign:1.39.8"
     CDS             790..2670
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /note="isoform b is encoded by transcript variant 2;
                     argonaute 3; protein argonaute-3; hAgo3; eIF2C 3; eIF-2C
                     3; argonaute3; eukaryotic translation initiation factor
                     2C, 3"
                     /codon_start=1
                     /product="protein argonaute-3 isoform b"
                     /protein_id="NP_803171.1"
                     /db_xref="GI:29337286"
                     /db_xref="CCDS:CCDS400.1"
                     /db_xref="GeneID:192669"
                     /db_xref="HGNC:18421"
                     /db_xref="MIM:607355"
                     /translation="
MCEVLDIHNIDEQPRPLTDSHRVKFTKEIKGLKVEVTHCGTMRRKYRVCNVTRRPASHQTFPLQLENGQTVERTVAQYFREKYTLQLKYPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKKLTDNQTSTMIKATARSAPDRQEEISRLVRSANYETDPFVQEFQFKVRDEMAHVTGRVLPAPMLQYGGRNRTVATPSHGVWDMRGKQFHTGVEIKMWAIACFATQRQCREEILKGFTDQLRKISKDAGMPIQGQPCFCKYAQGADSVEPMFRHLKNTYSGLQLIIVILPGKTPVYAEVKRVGDTLLGMATQCVQVKNVIKTSPQTLSNLCLKINVKLGGINNILVPHQRPSVFQQPVIFLGADVTHPPAGDGKKPSIAAVVGSMDAHPSRYCATVRVQRPRQEIIQDLASMVRELLIQFYKSTRFKPTRIIFYRDGVSEGQFRQVLYYELLAIREACISLEKDYQPGITYIVVQKRHHTRLFCADRTERVGRSGNIPAGTTVDTDITHPYEFDFYLCSHAGIQGTSRPSHYHVLWDDNCFTADELQLLTYQLCHTYVRCTRSVSIPAPAYYAHLVAFRARYHLVDKEHDSAEGSHVSGQSNGRDPQALAKAVQIHQDTLRTMYFA
"
     misc_feature    790..1131
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /note="PAZ domain, argonaute_like subfamily. Argonaute is
                     part of the RNA-induced silencing complex (RISC), and is
                     an endonuclease that plays a key role in the RNA
                     interference pathway. The PAZ domain has been named after
                     the proteins Piwi,Argonaut, and Zwille; Region:
                     PAZ_argonaute_like; cd02846"
                     /db_xref="CDD:239212"
     misc_feature    order(925..927,970..972,1012..1014,1024..1026,1078..1080,
                     1099..1101,1105..1107)
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /note="nucleic acid-binding interface [nucleotide
                     binding]; other site"
                     /db_xref="CDD:239212"
     misc_feature    1264..2541
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /note="Piwi_ago-like: PIWI domain, Argonaute-like
                     subfamily. Argonaute is the central component of the
                     RNA-induced silencing complex (RISC) and related
                     complexes. The PIWI domain is the C-terminal portion of
                     Argonaute and consists of two subdomains, one of...;
                     Region: Piwi_ago-like; cd04657"
                     /db_xref="CDD:240015"
     misc_feature    order(1675..1677,1687..1689,1723..1734,1741..1743,
                     1765..1767,1774..1776,1786..1788,1798..1800)
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /note="5' RNA guide strand anchoring site; other site"
                     /db_xref="CDD:240015"
     misc_feature    order(1879..1881,1885..1887,2095..2097,2509..2511)
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /note="active site"
                     /db_xref="CDD:240015"
     variation       814
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:368190615"
     variation       854
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:369030612"
     exon            881..968
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /inference="alignment:Splign:1.39.8"
     variation       917
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:202072346"
     variation       945
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:148681750"
     exon            969..1116
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /inference="alignment:Splign:1.39.8"
     variation       991
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201043874"
     variation       1011
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200735551"
     variation       1046
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:372692110"
     variation       1058
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:369662141"
     variation       1059
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:144067198"
     variation       1089
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:74645199"
     variation       1103
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:75667149"
     exon            1117..1236
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /inference="alignment:Splign:1.39.8"
     variation       1119
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:76924555"
     exon            1237..1359
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /inference="alignment:Splign:1.39.8"
     variation       1258
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201835772"
     variation       1274
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:149225833"
     variation       1296
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:41267265"
     exon            1360..1493
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /inference="alignment:Splign:1.39.8"
     variation       1486
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:147063309"
     variation       1489
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:368638136"
     exon            1494..1678
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /inference="alignment:Splign:1.39.8"
     variation       1588
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:199811357"
     variation       1629
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:111591152"
     variation       1648
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:143644991"
     variation       1659
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:138501451"
     exon            1679..1838
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /inference="alignment:Splign:1.39.8"
     variation       1691
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:369221869"
     variation       1714
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:373440270"
     variation       1721
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:200928613"
     variation       1737
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:144600568"
     variation       1747
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:143959736"
     variation       1761
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:111936785"
     variation       1803
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:377736680"
     exon            1839..1929
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /inference="alignment:Splign:1.39.8"
     variation       1860
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:139849193"
     variation       1878
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:151098893"
     variation       1881
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:140083661"
     variation       1890
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:149864052"
     exon            1930..2124
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /inference="alignment:Splign:1.39.8"
     variation       1947
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201570403"
     variation       1957..1958
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /replace=""
                     /replace="a"
                     /db_xref="dbSNP:34104798"
     variation       2019
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:147699389"
     variation       2046
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:143283288"
     variation       2085
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:373780763"
     exon            2125..2259
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /inference="alignment:Splign:1.39.8"
     variation       2147..2148
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /replace=""
                     /replace="c"
                     /db_xref="dbSNP:5773515"
     variation       2204
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:138068024"
     variation       2214
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:368356934"
     exon            2260..2361
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /inference="alignment:Splign:1.39.8"
     variation       2296
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:370775699"
     variation       2328
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:145947091"
     exon            2362..2561
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /inference="alignment:Splign:1.39.8"
     variation       2430
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:79043007"
     variation       2460
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:148771081"
     exon            2562..3387
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /inference="alignment:Splign:1.39.8"
     variation       2564
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:111316219"
     variation       2607
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:376625988"
     variation       2664
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:61743816"
     variation       2695
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:372307716"
     STS             2750..2968
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /standard_name="SHGC-74579"
                     /db_xref="UniSTS:44843"
     variation       2909
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:181505762"
     variation       2915
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:144063400"
     variation       3082
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:186097878"
     variation       3113
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:190878180"
     STS             3217..3341
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /standard_name="RH102469"
                     /db_xref="UniSTS:96803"
     variation       3219
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:145974637"
     variation       3237
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:184219370"
     variation       3251..3252
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /replace=""
                     /replace="t"
                     /db_xref="dbSNP:150584454"
     variation       3377
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:140115844"
     polyA_site      3387
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
ORIGIN      
gagcttccggggcggccccgggcaggtcggcggcggcggcccgcagtcgtggaggagcggtgggagcgtcggcggccgcgggcgatgcaacttccggacgggactcccctctgtccgcgcctcacatctccccttcctctcgcctagtcctgtgccgttttccgtccgcgactcttccggcccagagctttcggagtgcggttgctcaggggaagccgtcgccgcccccgcctcggggccgagtgagagtgcccgtcgcgtcgcgccgcgtcgccccccgggccgcctccttgccgccagtggcgggctccgttctccctcgaagcactccccccagctccatgaatggaaatcggctccgcaggacccgctggggcccagcccctactcatggtgcccagaagacctggctatggcaccatgggcaaacccattaaactgctggctaactgttttcaagttgaaatcccaaagattgatgtctacctctatgaggtagatattaaaccagacaagtgtcctaggagagtgaacaggtagatttagacgttactttacctggggaaggtggaaaagatcgacctttcaaggtgtcaatcaaatttgtctctcgggtgagttggcacctactgcatgaagtactgacaggacggaccttgcctgagccactggaattagacaagccaatcagcactaaccctgtccatgccgttgatgtggtgctacgacatctgccctccatgaatttctgccactgccttctacaaagcacaacctgtaattcagttcatgtgtgaagttcttgatattcataatattgatgagcaaccaagacctctgactgattctcatcgggtaaaattcaccaaagagataaaaggtttgaaggttgaagtgactcattgtggaacaatgagacggaaataccgtgtttgtaatgtaacaaggaggcctgccagtcatcaaacctttcctttacagttagaaaacggccaaactgtggagagaacagtagcgcagtatttcagagaaaagtatactcttcagctgaagtacccgcaccttccctgtctgcaagtcgggcaggaacagaaacacacctacctgccactagaagtctgtaatattgtggcagggcaacgatgtatcaagaagctaacagacaatcagacttccactatgatcaaggcaacagcaagatctgcaccagatagacaagaggaaattagcagattggtaagaagtgcaaattatgaaacagatccatttgttcaggagtttcaatttaaagttcgggatgaaatggctcatgtaactggacgcgtacttccagcacctatgctccagtatggaggacggaatcggacagtagcaacaccgagccatggagtatgggacatgcgagggaaacaattccacacaggagttgaaatcaaaatgtgggctatcgcttgttttgccacacagaggcagtgcagagaagaaatattgaagggtttcacagaccagctgcgtaagatttctaaggatgcagggatgcccatccagggccagccatgcttctgcaaatatgcacagggggcagacagcgtagagcccatgttccggcatctcaagaacacatattctggcctacagcttattatcgtcatcctgccggggaagacaccagtgtatgcggaagtgaaacgtgtaggagacacacttttgggtatggctacacaatgtgttcaagtcaagaatgtaataaaaacatctcctcaaactctgtcaaacttgtgcctaaagataaatgttaaactcggagggatcaataatattcttgtacctcatcaaagaccttctgtgttccagcaaccagtgatctttttgggagccgatgtcactcatccacctgctggtgatggaaagaagccttctattgctgctgttgtaggtagtatggatgcacacccaagcagatactgtgccacagtaagagttcagagaccccgacaggagatcatccaggacttggcctccatggtccgggaacttcttattcaattttataagtcaactcggttcaagcctactcgtatcatcttttatcgggatggtgtttcagaggggcagtttaggcaggtattatattatgaactactagcaattcgagaagcctgcatcagtttggagaaagactatcaacctggaataacctacattgtagttcagaagagacatcacactcgattattttgtgctgataggacagaaagggttggaagaagtggcaatatcccagctggaacaacagttgatacagacattacacacccatatgagttcgatttttacctctgtagccatgctggaatacagggtaccagtcgtccttcacactatcatgttttatgggatgataactgctttactgcagatgaacttcagctgctaacttaccagctctgccacacttacgtacgctgtacacgatctgtttctatacctgcaccagcgtattatgctcacctggtagcatttagagccagatatcatcttgtggacaaagaacatgacagtgctgaaggaagtcacgtttcaggacaaagcaatgggcgagatccacaagctcttgccaaggctgtacagattcaccaagataccttacgcacaatgtacttcgcttaaatagtccaagtatattctctgagaggaagtactgaaagatgaattgacatacaacgtatgtttccagtgaagtcaattgagtaaggacacctccagccatacagaaaccaacactgtgtgggggccaaggtctgatccttatgttaatacaaggaagattgtttacttcatcaaggaacacagcatcattatgcaatatgaaaccagccaactgctttttgtgcggtctcctataggaagtatcgcaattgttttgttttcatttcttgtagtctaacccttttaatgcctttacctcaagttgcttggcagcacaactatctttgcaaaaaaaagtaaagaaaaagtaaatgatggtttaaaaaatacacaccttcatgaataatcaaagtgatttttcagaattatgtgtgcaaaaaattaatgtgcattcatatattcttgtaaaaggtgtctgtgtatttttaaaatatatacatccatacttcatatgcatatatatctagatctggattgataatagatatatatgtgtctgttatatattttagagttcattccattggggaattttctttcccttttattctacccccactaccgcctttatttctctatttcccttgccttcatcacctacatttttttcccagtcctaccagtgacattcaaatgttgatgtatctggttcgtttgaatataaaatatggcaaactaaaaaaaaaaaaaaaaaaaaaaa
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:192669 -> Molecular function: GO:0003723 [RNA binding] evidence: IEA
            GeneID:192669 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
            GeneID:192669 -> Biological process: GO:0006402 [mRNA catabolic process] evidence: IDA
            GeneID:192669 -> Biological process: GO:0007173 [epidermal growth factor receptor signaling pathway] evidence: TAS
            GeneID:192669 -> Biological process: GO:0007219 [Notch signaling pathway] evidence: TAS
            GeneID:192669 -> Biological process: GO:0008543 [fibroblast growth factor receptor signaling pathway] evidence: TAS
            GeneID:192669 -> Biological process: GO:0010467 [gene expression] evidence: TAS
            GeneID:192669 -> Biological process: GO:0035278 [negative regulation of translation involved in gene silencing by miRNA] evidence: IDA
            GeneID:192669 -> Biological process: GO:0038095 [Fc-epsilon receptor signaling pathway] evidence: TAS
            GeneID:192669 -> Biological process: GO:0045087 [innate immune response] evidence: TAS
            GeneID:192669 -> Biological process: GO:0048011 [neurotrophin TRK receptor signaling pathway] evidence: TAS
            GeneID:192669 -> Biological process: GO:0048015 [phosphatidylinositol-mediated signaling] evidence: TAS
            GeneID:192669 -> Biological process: GO:0072091 [regulation of stem cell proliferation] evidence: IMP
            GeneID:192669 -> Cellular component: GO:0000932 [cytoplasmic mRNA processing body] evidence: IEA
            GeneID:192669 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
            GeneID:192669 -> Cellular component: GO:0035068 [micro-ribonucleoprotein complex] evidence: IEA

by @meso_cacase at DBCLS
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