LOCUS       NM_177400               1019 bp    mRNA    linear   PRI 17-APR-2013
DEFINITION  Homo sapiens NK6 homeobox 2 (NKX6-2), mRNA.
ACCESSION   NM_177400
VERSION     NM_177400.2  GI:149773526
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1019)
  AUTHORS   Lee,S.H., Davison,J.A., Vidal,S.M. and Belouchi,A.
  TITLE     Cloning, expression and chromosomal location of NKX6B TO 10Q26, a
            region frequently deleted in brain tumors
  JOURNAL   Mamm. Genome 12 (2), 157-162 (2001)
   PUBMED   11210186
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC104823.1 and BF509028.1.
            On Jun 26, 2007 this sequence version replaced gi:28912911.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC101635.1, BF509028.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           ERS025082, ERS025084 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-997               BC104823.1         1-997
            998-1019            BF509028.1         628-649
FEATURES             Location/Qualifiers
     source          1..1019
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q26"
     gene            1..1019
                     /gene="NKX6-2"
                     /gene_synonym="GTX; NKX6.2; NKX6B"
                     /note="NK6 homeobox 2"
                     /db_xref="GeneID:84504"
                     /db_xref="HGNC:19321"
                     /db_xref="HPRD:09336"
                     /db_xref="MIM:605955"
     STS             1..997
                     /gene="NKX6-2"
                     /gene_synonym="GTX; NKX6.2; NKX6B"
                     /db_xref="UniSTS:486958"
     exon            1..491
                     /gene="NKX6-2"
                     /gene_synonym="GTX; NKX6.2; NKX6B"
                     /inference="alignment:Splign:1.39.8"
     CDS             86..919
                     /gene="NKX6-2"
                     /gene_synonym="GTX; NKX6.2; NKX6B"
                     /note="glial and testis-specific homeobox protein;
                     homeobox 6B; NK homeobox family 6, B; homeobox protein
                     NK-6 homolog B; NK6 transcription factor related, locus 2"
                     /codon_start=1
                     /product="homeobox protein Nkx-6.2"
                     /protein_id="NP_796374.1"
                     /db_xref="GI:28912912"
                     /db_xref="CCDS:CCDS7670.1"
                     /db_xref="GeneID:84504"
                     /db_xref="HGNC:19321"
                     /db_xref="HPRD:09336"
                     /db_xref="MIM:605955"
                     /translation="

MDTNRPGAFVLSSAPLAALHNMAEMKTSLFPYALQGPAGFKAPALGGLGAQLPLGTPHGISDILGRPVGAAGGGLLGGLPRLNGLASSAGVYFGPAAAVARGYPKPLAELPGRPPIFWPGVVQGAPWRDPRLAGPAPAGGVLDKDGKKKHSRPTFSGQQIFALEKTFEQTKYLAGPERARLAYSLGMTESQVKVWFQNRRTKWRKRHAAEMASAKKKQDSDAEKLKVGGSDAEDDDEYNRPLDPNSDDEKITRLLKKHKPSNLALVSPCGGGAGDAL

"
     misc_feature    530..706
                     /gene="NKX6-2"
                     /gene_synonym="GTX; NKX6.2; NKX6B"
                     /note="Homeodomain;  DNA binding domains involved in the
                     transcriptional regulation of key eukaryotic developmental
                     processes; may bind to DNA as monomers or as homo- and/or
                     heterodimers, in a sequence-specific manner; Region:
                     homeodomain; cd00086"
                     /db_xref="CDD:28970"
     misc_feature    order(530..544,548..550,599..601,617..619,656..658,
                     662..667,674..679,683..691,695..700)
                     /gene="NKX6-2"
                     /gene_synonym="GTX; NKX6.2; NKX6B"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:28970"
     misc_feature    order(536..538,545..547,665..667,674..679,686..688)
                     /gene="NKX6-2"
                     /gene_synonym="GTX; NKX6.2; NKX6B"
                     /note="specific DNA base contacts [nucleotide binding];
                     other site"
                     /db_xref="CDD:28970"
     exon            492..664
                     /gene="NKX6-2"
                     /gene_synonym="GTX; NKX6.2; NKX6B"
                     /inference="alignment:Splign:1.39.8"
     exon            665..1019
                     /gene="NKX6-2"
                     /gene_synonym="GTX; NKX6.2; NKX6B"
                     /inference="alignment:Splign:1.39.8"
     variation       711
                     /gene="NKX6-2"
                     /gene_synonym="GTX; NKX6.2; NKX6B"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:2804003"
ORIGIN      

gccgcgcgcaaacttcccgggccggcgggcaggggcggcggcggcggggcccggatgggagcccgggccggcggcggcggcgcccatggacactaaccgcccgggcgcgttcgtgctgagcagtgccccgctggccgcgctgcacaacatggccgagatgaagacgtcgctgttcccctacgcgctgcagggtccggccggcttcaaggcgcccgcgctggggggcctgggcgcgcagctcccgctcgggaccccgcacggcatcagcgacatcctgggccggcccgtgggcgcggcgggcgggggcctcctgggggggctgccccggctcaacgggctcgcgtcgtccgccggcgtttacttcgggcccgcggccgctgtggcgcgcggctaccccaagcccctggccgagctgccggggcgcccgcccatcttctggcccggcgtggtgcagggcgcgccctggagggacccgcgtctggctggcccggccccggccggcggcgtcctggacaaggacgggaagaagaagcactcgcgcccgaccttctcgggccagcagatcttcgcgctggagaaaaccttcgagcagaccaagtacctggcgggcccggagcgcgcgcgtctcgcctactcgctgggcatgaccgagagccaggtgaaggtctggttccagaaccgccggaccaagtggcgcaagcggcacgcggcggagatggcgtcggccaagaagaagcaggactcggacgccgagaagctgaaggtgggcggctcggacgcggaggacgacgacgaatacaaccggcccctggaccccaactcggacgacgagaagatcacgcggctgctcaagaagcacaaaccctcgaacttggcgctggtcagcccgtgcggcggcggcgcgggggacgccttgtgaggacccgcggggtgggggcgaatctatttttgcagaatccgggggcggccccgggtgggcgcgagtcgctttgtatcatcaataaattatttaacgggtc

//

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:84504 -> Molecular function: GO:0000976 [transcription regulatory region sequence-specific DNA binding] evidence: IEA
            GeneID:84504 -> Molecular function: GO:0003700 [sequence-specific DNA binding transcription factor activity] evidence: NAS
            GeneID:84504 -> Biological process: GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] evidence: IEA
            GeneID:84504 -> Biological process: GO:0006355 [regulation of transcription, DNA-dependent] evidence: NAS
            GeneID:84504 -> Biological process: GO:0010454 [negative regulation of cell fate commitment] evidence: IEA
            GeneID:84504 -> Biological process: GO:0010455 [positive regulation of cell fate commitment] evidence: IEA
            GeneID:84504 -> Biological process: GO:0021912 [regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification] evidence: IEA
            GeneID:84504 -> Biological process: GO:0021913 [regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification] evidence: IEA
            GeneID:84504 -> Biological process: GO:0022010 [central nervous system myelination] evidence: IEA
            GeneID:84504 -> Biological process: GO:0031018 [endocrine pancreas development] evidence: IEA
            GeneID:84504 -> Biological process: GO:0045686 [negative regulation of glial cell differentiation] evidence: IEA
            GeneID:84504 -> Biological process: GO:0045687 [positive regulation of glial cell differentiation] evidence: IEA
            GeneID:84504 -> Biological process: GO:0050885 [neuromuscular process controlling balance] evidence: IEA
            GeneID:84504 -> Cellular component: GO:0005634 [nucleus] evidence: NAS