2024-03-29 20:19:37, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_153485 4600 bp mRNA linear PRI 17-JUN-2013 DEFINITION Homo sapiens nucleoporin 155kDa (NUP155), transcript variant 1, mRNA. ACCESSION NM_153485 VERSION NM_153485.2 GI:509155834 KEYWORDS RefSeq. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 4600) AUTHORS Tarazon,E., Rivera,M., Rosello-Lleti,E., Molina-Navarro,M.M., Sanchez-Lazaro,I.J., Espana,F., Montero,J.A., Lago,F., Gonzalez-Juanatey,J.R. and Portoles,M. TITLE Heart failure induces significant changes in nuclear pore complex of human cardiomyocytes JOURNAL PLoS ONE 7 (11), E48957 (2012) PUBMED 23152829 REFERENCE 2 (bases 1 to 4600) AUTHORS Parvez,B. and Darbar,D. TITLE The 'missing' link in atrial fibrillation heritability JOURNAL J Electrocardiol 44 (6), 641-644 (2011) PUBMED 21924735 REFERENCE 3 (bases 1 to 4600) AUTHORS Kehat,I., Accornero,F., Aronow,B.J. and Molkentin,J.D. TITLE Modulation of chromatin position and gene expression by HDAC4 interaction with nucleoporins JOURNAL J. Cell Biol. 193 (1), 21-29 (2011) PUBMED 21464227 REMARK GeneRIF: The Nup155-mediated localization was required for HDAC4's effect on gene expression. REFERENCE 4 (bases 1 to 4600) AUTHORS Mitchell,J.M., Mansfeld,J., Capitanio,J., Kutay,U. and Wozniak,R.W. TITLE Pom121 links two essential subcomplexes of the nuclear pore complex core to the membrane JOURNAL J. Cell Biol. 191 (3), 505-521 (2010) PUBMED 20974814 REMARK GeneRIF: The Nup155 depletion massively alters nuclear envelope structure, causing a dramatic decrease in Nuclear pore complexes numbers and the improper targeting of membrane proteins to the inner nuclear membrane. REFERENCE 5 (bases 1 to 4600) AUTHORS Rayala,H.J., Kendirgi,F., Barry,D.M., Majerus,P.W. and Wente,S.R. TITLE The mRNA export factor human Gle1 interacts with the nuclear pore complex protein Nup155 JOURNAL Mol. Cell Proteomics 3 (2), 145-155 (2004) PUBMED 14645504 REFERENCE 6 (bases 1 to 4600) AUTHORS Le Rouzic,E., Mousnier,A., Rustum,C., Stutz,F., Hallberg,E., Dargemont,C. and Benichou,S. TITLE Docking of HIV-1 Vpr to the nuclear envelope is mediated by the interaction with the nucleoporin hCG1 JOURNAL J. Biol. Chem. 277 (47), 45091-45098 (2002) PUBMED 12228227 REFERENCE 7 (bases 1 to 4600) AUTHORS Zhang,X., Yang,H., Yu,J., Chen,C., Zhang,G., Bao,J., Du,Y., Kibukawa,M., Li,Z., Wang,J., Hu,S., Dong,W., Wang,J., Gregersen,N., Niebuhr,E. and Bolund,L. TITLE Genomic organization, transcript variants and comparative analysis of the human nucleoporin 155 (NUP155) gene JOURNAL Gene 288 (1-2), 9-18 (2002) PUBMED 12034489 REFERENCE 8 (bases 1 to 4600) AUTHORS Shiota,C., Coffey,J., Grimsby,J., Grippo,J.F. and Magnuson,M.A. TITLE Nuclear import of hepatic glucokinase depends upon glucokinase regulatory protein, whereas export is due to a nuclear export signal sequence in glucokinase JOURNAL J. Biol. Chem. 274 (52), 37125-37130 (1999) PUBMED 10601273 REFERENCE 9 (bases 1 to 4600) AUTHORS Zhang,X., Yang,H., Corydon,M.J., Zhang,X., Pedersen,S., Korenberg,J.R., Chen,X.N., Laporte,J., Gregersen,N., Niebuhr,E., Liu,G. and Bolund,L. TITLE Localization of a human nucleoporin 155 gene (NUP155) to the 5p13 region and cloning of its cDNA JOURNAL Genomics 57 (1), 144-151 (1999) PUBMED 10191094 REFERENCE 10 (bases 1 to 4600) AUTHORS Gorlich,D. and Mattaj,I.W. TITLE Nucleocytoplasmic transport JOURNAL Science 271 (5255), 1513-1518 (1996) PUBMED 8599106 REMARK Review article COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC401967.1, BC039257.1, BM478072.1, AI037962.1 and BQ435836.1. On Jun 4, 2013 this sequence version replaced gi:24430148. Summary: Nucleoporins are proteins that play an important role in the assembly and functioning of the nuclear pore complex (NPC) which regulates the movement of macromolecules across the nuclear envelope (NE). The protein encoded by this gene plays a role in the fusion of NE vesicles and formation of the double membrane NE. The protein may also be involved in cardiac physiology and may be associated with the pathogenesis of atrial fibrillation. Alternative splicing results in multiple transcript variants of this gene. A pseudogene associated with this gene is located on chromosome 6. [provided by RefSeq, May 2013]. Transcript Variant: This variant (1) encodes the longest isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC039257.1, AJ007558.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support ERS025081, ERS025082 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-33 DC401967.1 1-33 34-349 BC039257.1 1-316 350-350 BM478072.1 254-254 351-4385 BC039257.1 318-4352 4386-4571 AI037962.1 30-215 c 4572-4576 BQ435836.1 683-687 4577-4600 AI037962.1 1-24 c FEATURES Location/Qualifiers source 1..4600 /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="5" /map="5p13.1" gene 1..4600 /gene="NUP155" /gene_synonym="N155" /note="nucleoporin 155kDa" /db_xref="GeneID:9631" /db_xref="HGNC:8063" /db_xref="HPRD:05984" /db_xref="MIM:606694" exon 1..306 /gene="NUP155" /gene_synonym="N155" /inference="alignment:Splign:1.39.8" CDS 150..4325 /gene="NUP155" /gene_synonym="N155" /note="isoform 1 is encoded by transcript variant 1; nuclear pore complex protein Nup155; 155 kDa nucleoporin" /codon_start=1 /product="nuclear pore complex protein Nup155 isoform 1" /protein_id="NP_705618.1" /db_xref="GI:24430149" /db_xref="CCDS:CCDS3921.1" /db_xref="GeneID:9631" /db_xref="HGNC:8063" /db_xref="HPRD:05984" /db_xref="MIM:606694" /translation="
MPSSLLGAAMPASTSAAALQEALENAGRLIDRQLQEDRMYPDLSELLMVSAPNNPTVSGMSDMDYPLQGPGLLSVPNLPEISSIRRVPLPPELVEQFGHMQCNCMMGVFPPISRAWLTIDSDIFMWNYEDGGDLAYFDGLSETILAVGLVKPKAGIFQPHVRHLLVLATPVDIVILGLSYANLQTGSGVLNDSLSGGMQLLPDPLYSLPTDNTYLLTITSTDNGRIFLAGKDGCLYEVAYQAEAGWFSQRCRKINHSKSSLSFLVPSLLQFTFSEDDPILQIAIDNSRNILYTRSEKGVIQVYDLGQDGQGMSRVASVSQNAIVSAAGNIARTIDRSVFKPIVQIAVIENSESLDCQLLAVTHAGVRLYFSTCPFRQPLARPNTLTLVHVRLPPGFSASSTVEKPSKVHRALYSKGILLMAASENEDNDILWCVNHDTFPFQKPMMETQMTAGVDGHSWALSAIDELKVDKIITPLNKDHIPITDSPVVVQQHMLPPKKFVLLSAQGSLMFHKLRPVDQLRHLLVSNVGGDGEEIERFFKLHQEDQACATCLILACSTAACDREVSAWATRAFFRYGGEAQMRFPTTLPPPSNVGPILGSPVYSSSPVPSGSPYPNPSFLGTPSHGIQPPAMSTPVCALGNPATQATNMSCVTGPEIVYSGKHNGICIYFSRIMGNIWDASLVVERIFKSGNREITAIESSVPCQLLESVLQELKGLQEFLDRNSQFAGGPLGNPNTTAKVQQRLIGFMRPENGNPQQMQQELQRKFHEAQLSEKISLQAIQQLVRKSYQALALWKLLCEHQFTIIVAELQKELQEQLKITTFKDLVIRDKELTGALIASLINCYIRDNAAVDGISLHLQDICPLLYSTDDAICSKANELLQRSRQVQNKTEKERMLRESLKEYQKISNQVDLSNVCAQYRQVRFYEGVVELSLTAAEKKDPQGLGLHFYKHGEPEEDIVGLQAFQERLNSYKCITDTLQELVNQSKAAPQSPSVPKKPGPPVLSSDPNMLSNEEAGHHFEQMLKLSQRSKDELFSIALYNWLIQVDLADKLLQVASPFLEPHLVRMAKVDQNRVRYMDLLWRYYEKNRSFSNAARVLSRLADMHSTEISLQQRLEYIARAILSAKSSTAISSIAADGEFLHELEEKMEVARIQLQIQETLQRQYSHHSSVQDAVSQLDSELMDITKLYGEFADPFKLAECKLAIIHCAGYSDPILVQTLWQDIIEKELSDSVTLSSSDRMHALSLKIVLLGKIYAGTPRFFPLDFIVQFLEQQVCTLNWDVGFVIQTMNEIGVPLPRLLEVYDQLFKSRDPFWNRMKKPLHLLDCIHVLLIRYVENPSQVLNCERRRFTNLCLDAVCGYLVELQSMSSSVAVQAITGNFKSLQAKLERLH
" misc_feature 375..1676 /gene="NUP155" /gene_synonym="N155" /note="Nup133 N terminal like; Region: Nucleoporin_N; pfam08801" /db_xref="CDD:204070" misc_feature 2247..3914 /gene="NUP155" /gene_synonym="N155" /note="Non-repetitive/WGA-negative nucleoporin C-terminal; Region: Nucleoporin_C; pfam03177" /db_xref="CDD:190553" exon 307..444 /gene="NUP155" /gene_synonym="N155" /inference="alignment:Splign:1.39.8" exon 445..541 /gene="NUP155" /gene_synonym="N155" /inference="alignment:Splign:1.39.8" exon 542..612 /gene="NUP155" /gene_synonym="N155" /inference="alignment:Splign:1.39.8" exon 613..705 /gene="NUP155" /gene_synonym="N155" /inference="alignment:Splign:1.39.8" exon 706..872 /gene="NUP155" /gene_synonym="N155" /inference="alignment:Splign:1.39.8" exon 873..978 /gene="NUP155" /gene_synonym="N155" /inference="alignment:Splign:1.39.8" exon 979..1052 /gene="NUP155" /gene_synonym="N155" /inference="alignment:Splign:1.39.8" exon 1053..1144 /gene="NUP155" /gene_synonym="N155" /inference="alignment:Splign:1.39.8" exon 1145..1242 /gene="NUP155" /gene_synonym="N155" /inference="alignment:Splign:1.39.8" exon 1243..1395 /gene="NUP155" /gene_synonym="N155" /inference="alignment:Splign:1.39.8" exon 1396..1496 /gene="NUP155" /gene_synonym="N155" /inference="alignment:Splign:1.39.8" exon 1497..1667 /gene="NUP155" /gene_synonym="N155" /inference="alignment:Splign:1.39.8" exon 1668..1778 /gene="NUP155" /gene_synonym="N155" /inference="alignment:Splign:1.39.8" exon 1779..1873 /gene="NUP155" /gene_synonym="N155" /inference="alignment:Splign:1.39.8" exon 1874..1962 /gene="NUP155" /gene_synonym="N155" /inference="alignment:Splign:1.39.8" exon 1963..2025 /gene="NUP155" /gene_synonym="N155" /inference="alignment:Splign:1.39.8" exon 2026..2173 /gene="NUP155" /gene_synonym="N155" /inference="alignment:Splign:1.39.8" exon 2174..2240 /gene="NUP155" /gene_synonym="N155" /inference="alignment:Splign:1.39.8" exon 2241..2356 /gene="NUP155" /gene_synonym="N155" /inference="alignment:Splign:1.39.8" exon 2357..2454 /gene="NUP155" /gene_synonym="N155" /inference="alignment:Splign:1.39.8" exon 2455..2585 /gene="NUP155" /gene_synonym="N155" /inference="alignment:Splign:1.39.8" exon 2586..2777 /gene="NUP155" /gene_synonym="N155" /inference="alignment:Splign:1.39.8" exon 2778..2916 /gene="NUP155" /gene_synonym="N155" /inference="alignment:Splign:1.39.8" exon 2917..3052 /gene="NUP155" /gene_synonym="N155" /inference="alignment:Splign:1.39.8" exon 3053..3206 /gene="NUP155" /gene_synonym="N155" /inference="alignment:Splign:1.39.8" exon 3207..3311 /gene="NUP155" /gene_synonym="N155" /inference="alignment:Splign:1.39.8" exon 3312..3466 /gene="NUP155" /gene_synonym="N155" /inference="alignment:Splign:1.39.8" exon 3467..3596 /gene="NUP155" /gene_synonym="N155" /inference="alignment:Splign:1.39.8" STS 3523..3684 /gene="NUP155" /gene_synonym="N155" /standard_name="MARC_21512-21513:1032982746:3" /db_xref="UniSTS:268564" exon 3597..3710 /gene="NUP155" /gene_synonym="N155" /inference="alignment:Splign:1.39.8" exon 3711..3831 /gene="NUP155" /gene_synonym="N155" /inference="alignment:Splign:1.39.8" exon 3832..3942 /gene="NUP155" /gene_synonym="N155" /inference="alignment:Splign:1.39.8" exon 3943..4079 /gene="NUP155" /gene_synonym="N155" /inference="alignment:Splign:1.39.8" exon 4080..4186 /gene="NUP155" /gene_synonym="N155" /inference="alignment:Splign:1.39.8" exon 4187..4592 /gene="NUP155" /gene_synonym="N155" /inference="alignment:Splign:1.39.8" polyA_signal 4364..4369 /gene="NUP155" /gene_synonym="N155" polyA_site 4387 /gene="NUP155" /gene_synonym="N155" /note="This is an internal site." polyA_signal 4569..4574 /gene="NUP155" /gene_synonym="N155" polyA_site 4592 /gene="NUP155" /gene_synonym="N155" ORIGIN
atgaagcggaagtgcgtcatgtcgaggcgccaaggcgctcgtttggcgcgcgcgccctaggcggcggatctaagctaacttcttggatcttttcttgtttctccttggtttttgactttttctggaccctggtgtctacgatttccgagatgccgtcttctttgttgggcgcggcgatgccggcctctacatctgccgcagccctgcaggaagctctggaaaatgctggacggctcatcgaccgtcagttgcaagaggaccgcatgtacccggacctttccgagctgcttatggtgtctgccccaaataatcccaccgtttctggcatgtcagatatggattatcctttgcaaggacctggtttgctgtccgtacccaaccttccagagatcagttccatccgaagagttcctctcccacctgaacttgttgagcagtttggacatatgcagtgtaattgcatgatgggtgtgttccctcctatcagcagagcttggctcacaattgacagtgatatattcatgtggaactatgaggatggaggagaccttgcctattttgatggacttagtgagactattcttgctgtggggcttgtgaagccaaaagcaggcatctttcaacctcatgtgcgacacctcctggttttggcgacccctgtagacatagtaattcttggactcagctatgctaatttgcaaacaggttctggagttcttaatgatagtttgtctggtggaatgcagttgcttccagatcctttatattctcttcctactgataatacttaccttttaacaataacttccactgataatggcagaattttcttggctggaaaggatggctgtttatatgaagtagcctaccaggctgaagcagggtggtttagccaaagatgtaggaaaataaaccactcaaagagctcactttctttccttgttccttccttgctacaattcacgttctcagaagatgatcctattcttcaaattgcaattgataattctagaaatattttatatacacgatctgagaaaggagtaatacaggtgtatgatttgggacaagatggacaaggaatgagcagagttgcctctgtgtcacagaatgccattgtctctgctgctggtaacattgctaggaccatcgatcgttctgtttttaaaccaattgtccaaatagcagtgattgaaaattctgaatcactggactgtcagttattggctgtcacacatgcaggtgttaggttatattttagcacttgtccattcagacagccattagcacggcctaatacactgacgctggttcatgtccgcttacctcctggattctcagcatcttcaaccgtggaaaagccttcaaaagtacatagagctctttatagtaaaggtattctattgatggcagcctcagaaaatgaggataatgatattttatggtgtgtcaaccatgatacttttcctttccaaaagccaatgatggaaacccagatgacagctggtgttgatggtcattcctgggctctttctgcgatagatgaattgaaagtagataaaataattacacctttaaacaaggatcatattccaataactgattcaccagttgttgtacagcagcacatgttacctccgaagaaatttgttctcctctcagcacaggggagccttatgtttcataaacttagacctgtagatcaactgaggcatctacttgtgagtaatgtgggaggagatggagaagagattgaaagattctttaaattacatcaggaagaccaggcttgtgcaacttgccttattcttgcttgctccactgctgcctgtgatagagaagtatctgcctgggctactcgggctttctttaggtatggtggtgaagcacagatgagatttccaaccactcttccgcctccaagtaatgttggtcccatcttggggtctcctgtctattctagttctcctgttcctagtggtagtccctatccaaatccatcctttttgggaacaccgtctcatggtatacagcctcctgccatgtcaactccagtgtgtgctctgggaaacccagcaactcaggccacaaatatgagttgtgtgactggaccagagattgtgtactctggaaaacacaatggtatttgcatttacttttctcggatcatgggaaacatttgggatgcaagcttagttgtggagagaatattcaagagtggcaacagagagatcactgcaattgaaagtagtgttccctgccaactgctagagtcagtgctacaagaactaaagggtttgcaggaatttctagacagaaactcccagtttgcaggaggaccattaggaaatccaaatactactgctaaagtgcagcagaggctgataggattcatgcgtcctgaaaacggaaatccccagcaaatgcaacaggaactgcagaggaagtttcatgaggctcaactaagtgaaaagatttcacttcaggcaattcagcagttggttcgaaaatcatatcaggctctggctttatggaaacttctttgtgaacatcaattcactatcattgtggcagaacttcagaaggaacttcaagagcagctgaagatcaccacctttaaagatcttgtaatcagggacaaagaactcacaggggcattaattgcttctcttatcaactgctacatcagagataatgccgctgttgatggcattagtttacatttacaggatatctgcccacttctatatagcactgatgatgcaatttgttctaaggcaaatgagcttctccagcgttcccgacaagttcaaaataagactgaaaaagaaagaatgttaagggaatcattaaaggaatatcaaaaaattagcaatcaagtggacctttccaatgtttgtgctcagtatagacaagtgagattttatgagggtgtggtggaactttctcttacggctgcagagaaaaaagatcctcaaggtcttgggcttcatttctataaacatggagaaccagaagaagacatagttggacttcaggccttccaagaaagattaaacagttacaaatgcattacagacacacttcaagaactggtaaatcaaagtaaggccgctcctcagtctcccagtgtacccaaaaaacctggtcctccagtgttgtcatctgatccaaatatgctgagtaatgaagaagcaggacatcattttgaacaaatgcttaaattgtcacagcgatccaaggatgagctctttagtattgccctttataattggctaatacaagtcgaccttgcagataagctgctacaggttgcttctccatttctggagccacatctagtccgaatggccaaagttgatcaaaacagagttcgttatatggatttactctggcggtattacgagaagaacagaagtttcagtaatgctgctcgtgtactgtccagactggctgacatgcatagcacagaaatttcacttcagcagcgactagagtacattgctcgagccattcttagtgccaaaagttccactgccatttcatcaatagctgccgatggtgaatttcttcatgaattagaagaaaaaatggaggttgctaggatccaacttcagatacaggagacactacaaaggcagtattcccatcattcttctgtacaggatgcagtttctcagctggattctgagctgatggacataactaagctttatggggaatttgctgacccatttaaacttgcagagtgcaaacttgcaataattcattgtgccggttattcagaccctatattggtgcagacactttggcaagatatcatagagaaagaattgagtgacagtgtgacattgagctcctcggatagaatgcatgctcttagtctcaagattgttctccttggcaaaatttatgctggcacaccacgcttctttcctttagattttattgtacagtttttagaacagcaggtttgtactttgaactgggatgtgggcttcgtaatacagacaatgaatgaaattggagtaccattacctagactactagaagtttatgatcagttgttcaaatcacgggatccattctggaacagaatgaagaagccactgcaccttttggattgtatacatgtattattgataagatatgttgagaatcccagccaagttttaaattgtgaaaggagaagatttacaaatctctgcctggatgctgtttgtggttaccttgttgagctccagtctatgagctcgtcagtagcagtacaagccatcactgggaattttaaatctcttcaagctaaattagaacggcttcattaattactgtgatatactttcatccgttttatgatctgtaaaataaaaactcagctgggtccagatatcaggtgttctaaatctaagaatgtaagaacaatcttaatagaaatatgtttttaataagtggctaatatctacaaatagtacctttgctaaatgaattcttttttatgactattttgttttttagtaattgggtgaaaaaacaactgaaatgagattatttattattttaacataaggattaaaaaaatttagaaactcttaaaaaaaaa
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ANNOTATIONS from NCBI Entrez Gene (20130726): GeneID:9631 -> Molecular function: GO:0005215 [transporter activity] evidence: TAS GeneID:9631 -> Molecular function: GO:0017056 [structural constituent of nuclear pore] evidence: IEA GeneID:9631 -> Biological process: GO:0000278 [mitotic cell cycle] evidence: TAS GeneID:9631 -> Biological process: GO:0005975 [carbohydrate metabolic process] evidence: TAS GeneID:9631 -> Biological process: GO:0006406 [mRNA export from nucleus] evidence: IEA GeneID:9631 -> Biological process: GO:0006606 [protein import into nucleus] evidence: IEA GeneID:9631 -> Biological process: GO:0006998 [nuclear envelope organization] evidence: IDA GeneID:9631 -> Biological process: GO:0007077 [mitotic nuclear envelope disassembly] evidence: TAS GeneID:9631 -> Biological process: GO:0008645 [hexose transport] evidence: TAS GeneID:9631 -> Biological process: GO:0010827 [regulation of glucose transport] evidence: TAS GeneID:9631 -> Biological process: GO:0015758 [glucose transport] evidence: TAS GeneID:9631 -> Biological process: GO:0016032 [viral process] evidence: TAS GeneID:9631 -> Biological process: GO:0019221 [cytokine-mediated signaling pathway] evidence: TAS GeneID:9631 -> Biological process: GO:0044281 [small molecule metabolic process] evidence: TAS GeneID:9631 -> Biological process: GO:0055085 [transmembrane transport] evidence: TAS GeneID:9631 -> Biological process: GO:0086014 [regulation of atrial cardiac muscle cell action potential] evidence: IEA GeneID:9631 -> Cellular component: GO:0005635 [nuclear envelope] evidence: IDA GeneID:9631 -> Cellular component: GO:0005635 [nuclear envelope] evidence: TAS GeneID:9631 -> Cellular component: GO:0005643 [nuclear pore] evidence: IEA GeneID:9631 -> Cellular component: GO:0031965 [nuclear membrane] evidence: IEA
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