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2024-04-19 19:30:49, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_152446 4461 bp mRNA linear PRI 15-JUN-2013
DEFINITION Homo sapiens centrosomal protein 128kDa (CEP128), mRNA.
ACCESSION NM_152446 XM_496002
VERSION NM_152446.3 GI:194018736
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4461)
AUTHORS Wu,J.H., Lemaitre,R.N., Manichaikul,A., Guan,W., Tanaka,T., Foy,M.,
Kabagambe,E.K., Djousse,L., Siscovick,D., Fretts,A.M., Johnson,C.,
King,I.B., Psaty,B.M., McKnight,B., Rich,S.S., Chen,Y.D.,
Nettleton,J.A., Tang,W., Bandinelli,S., Jacobs,D.R. Jr.,
Browning,B.L., Laurie,C.C., Gu,X., Tsai,M.Y., Steffen,L.M.,
Ferrucci,L., Fornage,M. and Mozaffarian,D.
TITLE Genome-wide association study identifies novel loci associated with
concentrations of four plasma phospholipid fatty acids in the de
novo lipogenesis pathway: results from the Cohorts for Heart and
Aging Research in Genomic Epidemiology (CHARGE) consortium
JOURNAL Circ Cardiovasc Genet 6 (2), 171-183 (2013)
PUBMED 23362303
REFERENCE 2 (bases 1 to 4461)
AUTHORS Croteau-Chonka,D.C., Marvelle,A.F., Lange,E.M., Lee,N.R.,
Adair,L.S., Lange,L.A. and Mohlke,K.L.
TITLE Genome-wide association study of anthropometric traits and evidence
of interactions with age and study year in Filipino women
JOURNAL Obesity (Silver Spring) 19 (5), 1019-1027 (2011)
PUBMED 20966902
REMARK GeneRIF: Observational study and genome-wide association study of
gene-disease association. (HuGE Navigator)
REFERENCE 3 (bases 1 to 4461)
AUTHORS Jakobsen,L., Vanselow,K., Skogs,M., Toyoda,Y., Lundberg,E.,
Poser,I., Falkenby,L.G., Bennetzen,M., Westendorf,J., Nigg,E.A.,
Uhlen,M., Hyman,A.A. and Andersen,J.S.
TITLE Novel asymmetrically localizing components of human centrosomes
identified by complementary proteomics methods
JOURNAL EMBO J. 30 (8), 1520-1535 (2011)
PUBMED 21399614
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
BX248746.1, BC045834.1, DB320407.1, AC022404.7, AK056756.1,
CD366820.1 and AI937080.1.
On Jul 10, 2008 this sequence version replaced gi:64085251.
##Evidence-Data-START##
CDS exon combination :: BC150610.1 [ECO:0000331]
RNAseq introns :: mixed/partial sample support ERS025081,
ERS025082 [ECO:0000350]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-708 BX248746.1 162-869
709-1354 BC045834.1 816-1461
1355-1627 DB320407.1 111-383 c
1628-1731 DB320407.1 6-109 c
1732-2311 AC022404.7 156915-157494 c
2312-3087 AK056756.1 1-776
3088-3466 CD366820.1 263-641 c
3467-3894 AK056756.1 1156-1583
3895-4007 AK056756.1 1586-1698
4008-4227 AI937080.1 236-455 c
4228-4461 AI937080.1 1-234 c
FEATURES Location/Qualifiers
source 1..4461
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="14"
/map="14q31.1"
gene 1..4461
/gene="CEP128"
/gene_synonym="C14orf145; C14orf61; LEDP/132"
/note="centrosomal protein 128kDa"
/db_xref="GeneID:145508"
/db_xref="HGNC:20359"
exon 1..156
/gene="CEP128"
/gene_synonym="C14orf145; C14orf61; LEDP/132"
/inference="alignment:Splign:1.39.8"
variation 39
/gene="CEP128"
/gene_synonym="C14orf145; C14orf61; LEDP/132"
/replace="g"
/replace="t"
/db_xref="dbSNP:3742722"
misc_feature 70..72
/gene="CEP128"
/gene_synonym="C14orf145; C14orf61; LEDP/132"
/note="upstream in-frame stop codon"
exon 157..318
/gene="CEP128"
/gene_synonym="C14orf145; C14orf61; LEDP/132"
/inference="alignment:Splign:1.39.8"
CDS 172..3456
/gene="CEP128"
/gene_synonym="C14orf145; C14orf61; LEDP/132"
/note="lens epithelium-derived protein"
/codon_start=1
/product="centrosomal protein of 128 kDa"
/protein_id="NP_689659.2"
/db_xref="GI:64085252"
/db_xref="CCDS:CCDS32130.1"
/db_xref="GeneID:145508"
/db_xref="HGNC:20359"
/translation="
MAESSSESDHFRCRDRLSPWAARSTHRGTRSLPTVEVTEKVNTITSTLQDTSRNLRQVDQMLGRYREYSNGQAGAIEHLKESLEQSIDQLRSQRLLRNSGGRSISVTSLSASDLDGGTGSELHHFPPTSPLKDYGDPQGIKRMRSRTGVRFVQETDDMTQLHGFHQSLRDLSSEQIRLGDDFNRELSRRSRSDAETKRALEELTEKLNEAQKQEVVSDRVERRLQELEREMRTERELVERRQDQLGLMSLQLQEALKKQEAKADEHEGAIKNKLRQTETEKNQLEQELELSRRLLNQSEGSRETLLHQVEELRTQLTKAEGDRKGLQHQVSQISKQQSNYQDEQGEDWRFRRGVEREKQDLEKQMSDLRVQLNFSAMASELEEVKRCMERKDKEKAHLASQVENLTRELENGEKQQLQMLDRLKEIQNHFDTCEAERKHADLQISELTRHAEDATKQAERYLSELQQSEALKEEAEKRREDLKLKAQESIRQWKLKHKKLERALEKQSETVDELTGKNNQILKEKDELKTQLYAALQQIENLRKELNDVLTKRALQEEELHSKEEKLRDIKSHQADLELEVKNSLDTIHRLESELKKQSKIQSQMKVEKAHLEEEIAELKKSQAQDKAKLLEMQESIKDLSAIRADLANKLAEEERAKKAVLKDLSDLTAQAKSRDEETATIITQLKLERDVHQRELKDLTSSLQSVKTKHEQNIQELMKHFKKEKSEAENHIRTLKAESLEEKNMAKIHRGQLEKLKSQCDRLTEELTQNENENKKLKLKYQCLKDQLEEREKHISIEEEHLRRMEEARLQLKDQLLCLETEQESILGVIGKEIDAACKTFSKDSVEKLKVFSSGPDIHYDPHRWLAESKTKLQWLCEELKERENREKNLRHQLMLCRQQLRNLTENKESELQCLFQQIERQEQLLDEIHREKRDLLEETQRKDEEMGSLQDRVIALETSTQVALDHLESVPEKLSLLEDFKDFRDSCSSSERTDGRYSKYRVRRNSLQHHQDDTKYRTKSFKGDRTFLEGSHTRGLDHSSSWQDHSRFLSSPRFSYVNSFTKRTVAPDSASNKEDATMNGTSSQPKKEEYGS
"
misc_feature 1663..>2085
/gene="CEP128"
/gene_synonym="C14orf145; C14orf61; LEDP/132"
/note="Fms-interacting protein; Region: FimP; pfam09766"
/db_xref="CDD:204309"
misc_feature 2992..2994
/gene="CEP128"
/gene_synonym="C14orf145; C14orf61; LEDP/132"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 3019..3021
/gene="CEP128"
/gene_synonym="C14orf145; C14orf61; LEDP/132"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
exon 319..405
/gene="CEP128"
/gene_synonym="C14orf145; C14orf61; LEDP/132"
/inference="alignment:Splign:1.39.8"
exon 406..532
/gene="CEP128"
/gene_synonym="C14orf145; C14orf61; LEDP/132"
/inference="alignment:Splign:1.39.8"
exon 533..651
/gene="CEP128"
/gene_synonym="C14orf145; C14orf61; LEDP/132"
/inference="alignment:Splign:1.39.8"
exon 652..743
/gene="CEP128"
/gene_synonym="C14orf145; C14orf61; LEDP/132"
/inference="alignment:Splign:1.39.8"
exon 744..816
/gene="CEP128"
/gene_synonym="C14orf145; C14orf61; LEDP/132"
/inference="alignment:Splign:1.39.8"
exon 817..933
/gene="CEP128"
/gene_synonym="C14orf145; C14orf61; LEDP/132"
/inference="alignment:Splign:1.39.8"
exon 934..1020
/gene="CEP128"
/gene_synonym="C14orf145; C14orf61; LEDP/132"
/inference="alignment:Splign:1.39.8"
exon 1021..1095
/gene="CEP128"
/gene_synonym="C14orf145; C14orf61; LEDP/132"
/inference="alignment:Splign:1.39.8"
exon 1096..1228
/gene="CEP128"
/gene_synonym="C14orf145; C14orf61; LEDP/132"
/inference="alignment:Splign:1.39.8"
exon 1229..1380
/gene="CEP128"
/gene_synonym="C14orf145; C14orf61; LEDP/132"
/inference="alignment:Splign:1.39.8"
exon 1381..1731
/gene="CEP128"
/gene_synonym="C14orf145; C14orf61; LEDP/132"
/inference="alignment:Splign:1.39.8"
exon 1732..2382
/gene="CEP128"
/gene_synonym="C14orf145; C14orf61; LEDP/132"
/inference="alignment:Splign:1.39.8"
misc_feature <2151..>2730
/gene="CEP128"
/gene_synonym="C14orf145; C14orf61; LEDP/132"
/note="span covered by CTD-2308C24"
misc_feature <2151..>2730
/gene="CEP128"
/gene_synonym="C14orf145; C14orf61; LEDP/132"
/note="span covered by RP11-757H14"
exon 2383..2547
/gene="CEP128"
/gene_synonym="C14orf145; C14orf61; LEDP/132"
/inference="alignment:Splign:1.39.8"
exon 2548..2724
/gene="CEP128"
/gene_synonym="C14orf145; C14orf61; LEDP/132"
/inference="alignment:Splign:1.39.8"
exon 2725..2784
/gene="CEP128"
/gene_synonym="C14orf145; C14orf61; LEDP/132"
/inference="alignment:Splign:1.39.8"
exon 2785..2977
/gene="CEP128"
/gene_synonym="C14orf145; C14orf61; LEDP/132"
/inference="alignment:Splign:1.39.8"
exon 2978..3027
/gene="CEP128"
/gene_synonym="C14orf145; C14orf61; LEDP/132"
/inference="alignment:Splign:1.39.8"
exon 3028..3051
/gene="CEP128"
/gene_synonym="C14orf145; C14orf61; LEDP/132"
/inference="alignment:Splign:1.39.8"
exon 3052..3129
/gene="CEP128"
/gene_synonym="C14orf145; C14orf61; LEDP/132"
/inference="alignment:Splign:1.39.8"
exon 3130..3243
/gene="CEP128"
/gene_synonym="C14orf145; C14orf61; LEDP/132"
/inference="alignment:Splign:1.39.8"
exon 3244..3352
/gene="CEP128"
/gene_synonym="C14orf145; C14orf61; LEDP/132"
/inference="alignment:Splign:1.39.8"
exon 3353..4457
/gene="CEP128"
/gene_synonym="C14orf145; C14orf61; LEDP/132"
/inference="alignment:Splign:1.39.8"
ORIGIN
gtggtttggggaaagtgtaggggcaaccaaagatcatcggcttgactaggccctttgccctgaacctcatgaagaaatgataggaggcagacatatgtgcctaaaaagagcgttgagctcagagaagagcaactcggagttttgggggtgtgctttgatttgtgtacatcaatggcagaatcatccagcgaatcagatcacttccgctgtcgtgaccgattgagtccatgggctgccagatcaacgcacaggggaactcgaagtcttcctacagtagaagttaccgagaaggtcaacactataacaagtactttacaggataccagtcggaacctgcgacaagtggaccagatgcttggacgataccgagaatacagtaatggacaggcgggtgcgatagaacatttaaaagaaagcttggaacaatcaatcgaccaactccggagtcaacgtttattgagaaactcaggagggagaagtatttctgttacaagtttgagtgcaagtgaccttgatggtggcactgggtcagagctccatcattttccacctacctcacctctcaaggactatggggatccacagggtattaaacgaatgagatcaagaactggtgtccggtttgttcaagagactgatgatatgactcagcttcatggttttcatcagtctcttcgagacctcagcagtgaacaaattcgccttggagatgatttcaacagggagctttccagaaggagccggtcagatgccgaaacaaaaagggctttggaagaattgactgaaaaacttaatgaagcccagaaacaagaagtggtttcagatcgggtggagcggcggcttcaggaactggagagagagatgcgcacagaaagggagctggtggaaagacgccaggatcaactgggactcatgtccctgcagctacaggaggcactaaagaaacaagaagctaaagcagatgagcatgagggggcaataaaaaataagctaagacaaactgaaactgagaagaatcaacttgaacaggaattggagctatctcgaaggttattgaatcaatcagaaggcagccgagaaacacttttgcatcaggtagaagaactgcgtacacaacttacgaaagcagaaggtgatcgaaagggtttacagcatcaagtatctcagatttccaagcaacagtcaaactatcaggatgaacaaggggaggactggagatttaggagaggggttgagcgggaaaaacaggacctggagaagcaaatgtcagatttgagagtgcagctgaacttcagcgcaatggcatctgagttagaggaagtgaaacggtgcatggagagaaaagacaaggagaaagcacatttggcatcacaagtagagaatttaacacgtgaactggagaatggggaaaaacagcaactgcagatgttggatcgacttaaggagatccagaatcactttgacacatgtgaggccgagcgtaagcatgctgaccttcagatctcagagctgactcgccatgcggaggatgcaaccaagcaggctgagcggtacctcagtgagctccagcagtcagaggctctgaaagaggaggcggagaagaggagggaagacctgaaactgaaagctcaagaatccattaggcagtggaagcttaagcataagaagttagaacgagcgttggagaaacaatctgaaactgttgatgaactgacaggcaagaataatcagattttaaaagaaaaggatgaattgaaaacccagctgtatgcagcattacaacaaatagagaatcttcgaaaggaattgaatgatgtcctaacaaagcgtgcccttcaggaggaggagcttcactccaaggaggagaaattacgtgatattaagtctcatcaagctgaccttgaattggaagttaagaattccctggataccatccatagactggagagcgaattgaaaaagcagagtaagatccaaagccagatgaaagttgagaaagctcacttggaggaagaaattgcagagctcaagaagagccaggcccaggacaaagctaaacttcttgagatgcaagagtccatcaaggacctgagtgccatccgagcagatcttgctaataaattggctgaggaagagagagccaagaaagcagtgcttaaggacctttctgacctcactgcacaggcaaaatccagggatgaagaaacagctacaatcatcacacagttaaagctggaacgagatgtgcaccagagggagctgaaagatctcacatcatcattgcagagtgtgaaaacaaaacacgaacagaatatccaggagcttatgaagcactttaagaaagaaaagagtgaggctgagaatcatatcaggactctgaaggctgaaagtttagaagagaagaatatggctaaaattcatcgtggtcagctggagaagttgaaatcacagtgtgacagactgacagaggaattaacccagaatgaaaatgagaacaaaaaactgaagctaaaatatcaatgtttgaaggatcaactagaagaaagggaaaaacatataagcattgaagaggagcacttaaggaggatggaagaggccagattgcagctcaaggatcaacttctttgcttggagactgaacaggaatccattcttggtgtgataggaaaggaaattgatgcagcttgtaaaacattctccaaggactcagtggagaaattaaaagttttttcatctggtcctgatatacattatgacccacatcgctggttagcagaaagcaagactaaacttcagtggctctgtgaggaactgaaagagagagaaaacagagagaaaaatctgcgacaccagctgatgctctgcagacaacaactcaggaatttgactgaaaacaaggaatctgagttgcagtgtctctttcaacagatagaaaggcaggagcagcttctggatgaaatacatcgtgagaagagagatctactggaagagacccaaagaaaagatgaagaaatgggatctctgcaggaccgtgtaattgcattagaaacgagtacccaagtggccttggaccatctggagtctgtgcctgagaaactgagcctactagaagatttcaaagacttcagagattcctgcagttcatctgagagaactgatggaagatattccaaatacagggttcgcagaaattctcttcagcatcaccaagatgacaccaagtacagaaccaaaagtttcaaaggtgacagaacctttctggaaggttcccacactcgtgggttagatcactcatcctcttggcaggatcacagtcgcttcctgtctagtccaagattttcatacgtgaactcatttaccaaaagaactgttgctccagattcagcttcaaacaaggaagatgccacaatgaatggaacaagttcacaacccaaaaaagaggaatatgggagctaaaaaagcaaatgtaatttgttattttacatgagtatgttacaaataataacatctctattcttacagcaatttggcccagattatctaacagacatacctgcagctttggctctttggtattgccaaacattgacaaaagtgacaatactgttggtccttgtgaatggtaaaccaatccaaataatatcagatcatgaatgatgtgcagctaatttatttgcaacttatactagcacagaaagaatgatattttttcactttgtattttcctttttcaagtgtggtcagtcacattttcccaaccaaaatttggatttctaattgaggccttttaaaaattactggctaaaaagaaggaaaatgagtttcccttgaggcaaaagttgccagcactttagattcagggagcatttatatacaactgattttttgaaaaattttctccctaataaattatcatgtgttataacatgtggagatgtgcatatataacattagacagtccactttataaatgctcaggacttttatatctatcatcttaacagtccacaactgcataccgtagctgaaaattatttccaatcatccatttttaatagcaataaagaattcataaatgatatctgaactgtagagcactgtaaagaattcatagcacaatttatttatttgtctttttgtggccaaatatcctactgtgatcacttcagtcatatcctggaccgtctttggtttactgtgactaaaatcatagcaccaaactcctttgtccatgagatttatatataatcttgtataatttggtcctatctgcttctaccatcccaacttttttcatcaaagtgtctaagaacgtattccctttacacgctgatctcctagtggagaaggatttatattaaatgctaagtaatagtaaactttcaggaactgaatcctattgggtcatggattctgcatagacaagggcaataaagcaatacctttgtaatatgcataaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:145508 -> Cellular component: GO:0000922 [spindle pole] evidence: IDA
GeneID:145508 -> Cellular component: GO:0005814 [centriole] evidence: IDA
by
@meso_cacase at
DBCLS
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