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2024-04-23 17:11:43, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_145697 1989 bp mRNA linear PRI 05-JUL-2013
DEFINITION Homo sapiens NUF2, NDC80 kinetochore complex component (NUF2),
transcript variant 1, mRNA.
ACCESSION NM_145697
VERSION NM_145697.2 GI:117968419
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1989)
AUTHORS Sethi,G., Pathak,H.B., Zhang,H., Zhou,Y., Einarson,M.B.,
Vathipadiekal,V., Gunewardena,S., Birrer,M.J. and Godwin,A.K.
TITLE An RNA interference lethality screen of the human druggable genome
to identify molecular vulnerabilities in epithelial ovarian cancer
JOURNAL PLoS ONE 7 (10), E47086 (2012)
PUBMED 23056589
REMARK GeneRIF: NDC80, NUF2 and PTN were significantly aberrantly
overexpressed in serous adenocarcinomas.
REFERENCE 2 (bases 1 to 1989)
AUTHORS Sundin,L.J., Guimaraes,G.J. and Deluca,J.G.
TITLE The NDC80 complex proteins Nuf2 and Hec1 make distinct
contributions to kinetochore-microtubule attachment in mitosis
JOURNAL Mol. Biol. Cell 22 (6), 759-768 (2011)
PUBMED 21270439
REMARK GeneRIF: These data suggest that the CH and tail domains of Hec1
generate essential contacts between kinetochores and microtubules
in cells, whereas the Nuf2 CH domain does not.
REFERENCE 3 (bases 1 to 1989)
AUTHORS Olson,J.E., Wang,X., Pankratz,V.S., Fredericksen,Z.S., Vachon,C.M.,
Vierkant,R.A., Cerhan,J.R. and Couch,F.J.
TITLE Centrosome-related genes, genetic variation, and risk of breast
cancer
JOURNAL Breast Cancer Res. Treat. 125 (1), 221-228 (2011)
PUBMED 20508983
REMARK GeneRIF: Observational study of gene-disease association. (HuGE
Navigator)
REFERENCE 4 (bases 1 to 1989)
AUTHORS Kaneko,N., Miura,K., Gu,Z., Karasawa,H., Ohnuma,S., Sasaki,H.,
Tsukamoto,N., Yokoyama,S., Yamamura,A., Nagase,H., Shibata,C.,
Sasaki,I. and Horii,A.
TITLE siRNA-mediated knockdown against CDCA1 and KNTC2, both frequently
overexpressed in colorectal and gastric cancers, suppresses cell
proliferation and induces apoptosis
JOURNAL Biochem. Biophys. Res. Commun. 390 (4), 1235-1240 (2009)
PUBMED 19878654
REMARK GeneRIF: cell growths of colorectal and gastric cancers after the
siRNA-mediated knockdown of either CDCA1 or KNTC2 were
significantly suppressed.
REFERENCE 5 (bases 1 to 1989)
AUTHORS Ehret,G.B., O'Connor,A.A., Weder,A., Cooper,R.S. and Chakravarti,A.
TITLE Follow-up of a major linkage peak on chromosome 1 reveals
suggestive QTLs associated with essential hypertension: GenNet
study
JOURNAL Eur. J. Hum. Genet. 17 (12), 1650-1657 (2009)
PUBMED 19536175
REMARK GeneRIF: Observational study of gene-disease association. (HuGE
Navigator)
REFERENCE 6 (bases 1 to 1989)
AUTHORS Tien,A.C., Lin,M.H., Su,L.J., Hong,Y.R., Cheng,T.S., Lee,Y.C.,
Lin,W.J., Still,I.H. and Huang,C.Y.
TITLE Identification of the substrates and interaction proteins of aurora
kinases from a protein-protein interaction model
JOURNAL Mol. Cell Proteomics 3 (1), 93-104 (2004)
PUBMED 14602875
REFERENCE 7 (bases 1 to 1989)
AUTHORS DeLuca,J.G., Howell,B.J., Canman,J.C., Hickey,J.M., Fang,G. and
Salmon,E.D.
TITLE Nuf2 and Hec1 are required for retention of the checkpoint proteins
Mad1 and Mad2 to kinetochores
JOURNAL Curr. Biol. 13 (23), 2103-2109 (2003)
PUBMED 14654001
REFERENCE 8 (bases 1 to 1989)
AUTHORS DeLuca,J.G., Moree,B., Hickey,J.M., Kilmartin,J.V. and Salmon,E.D.
TITLE hNuf2 inhibition blocks stable kinetochore-microtubule attachment
and induces mitotic cell death in HeLa cells
JOURNAL J. Cell Biol. 159 (4), 549-555 (2002)
PUBMED 12438418
REMARK GeneRIF: Data highlight a specific role for hNuf2 in
kinetochore-microtubule attachment and suggest that hNuf2 is part
of a molecular linker between the kinetochore attachment site and
tubulin subunits within the lattice of attached plus ends.
REFERENCE 9 (bases 1 to 1989)
AUTHORS Nabetani,A., Koujin,T., Tsutsumi,C., Haraguchi,T. and Hiraoka,Y.
TITLE A conserved protein, Nuf2, is implicated in connecting the
centromere to the spindle during chromosome segregation: a link
between the kinetochore function and the spindle checkpoint
JOURNAL Chromosoma 110 (5), 322-334 (2001)
PUBMED 11685532
REFERENCE 10 (bases 1 to 1989)
AUTHORS Wigge,P.A. and Kilmartin,J.V.
TITLE The Ndc80p complex from Saccharomyces cerevisiae contains conserved
centromere components and has a function in chromosome segregation
JOURNAL J. Cell Biol. 152 (2), 349-360 (2001)
PUBMED 11266451
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from AL592435.2 and AK093348.1.
On Nov 15, 2006 this sequence version replaced gi:22027506.
Summary: This gene encodes a protein that is highly similar to
yeast Nuf2, a component of a conserved protein complex associated
with the centromere. Yeast Nuf2 disappears from the centromere
during meiotic prophase when centromeres lose their connection to
the spindle pole body, and plays a regulatory role in chromosome
segregation. The encoded protein is found to be associated with
centromeres of mitotic HeLa cells, which suggests that this protein
is a functional homolog of yeast Nuf2. Alternatively spliced
transcript variants that encode the same protein have been
described. [provided by RefSeq, Jul 2008].
Transcript Variant: This variant (1) represents the longer
transcript. Variants 1 and 2 encode the same protein.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: BG354574.1, AK093348.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025085 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-21 AL592435.2 66418-66438
22-1983 AK093348.1 1-1962
1984-1989 AL592435.2 100243-100248
FEATURES Location/Qualifiers
source 1..1989
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="1"
/map="1q23.3"
gene 1..1989
/gene="NUF2"
/gene_synonym="CDCA1; CT106; NUF2R"
/note="NUF2, NDC80 kinetochore complex component"
/db_xref="GeneID:83540"
/db_xref="HGNC:14621"
/db_xref="MIM:611772"
exon 1..280
/gene="NUF2"
/gene_synonym="CDCA1; CT106; NUF2R"
/inference="alignment:Splign:1.39.8"
variation 27
/gene="NUF2"
/gene_synonym="CDCA1; CT106; NUF2R"
/replace="a"
/replace="g"
/db_xref="dbSNP:189794484"
variation 125
/gene="NUF2"
/gene_synonym="CDCA1; CT106; NUF2R"
/replace="a"
/replace="g"
/db_xref="dbSNP:11557392"
exon 281..423
/gene="NUF2"
/gene_synonym="CDCA1; CT106; NUF2R"
/inference="alignment:Splign:1.39.8"
misc_feature 283..285
/gene="NUF2"
/gene_synonym="CDCA1; CT106; NUF2R"
/note="upstream in-frame stop codon"
variation 294
/gene="NUF2"
/gene_synonym="CDCA1; CT106; NUF2R"
/replace="g"
/replace="t"
/db_xref="dbSNP:372718799"
CDS 301..1695
/gene="NUF2"
/gene_synonym="CDCA1; CT106; NUF2R"
/note="cancer/testis antigen 106; cell division cycle
associated 1; hNuf2; hNuf2R; hsNuf2; cell division
cycle-associated protein 1; NUF2, NDC80 kinetochore
complex component, homolog"
/codon_start=1
/product="kinetochore protein Nuf2"
/protein_id="NP_663735.2"
/db_xref="GI:117968420"
/db_xref="CCDS:CCDS1245.1"
/db_xref="GeneID:83540"
/db_xref="HGNC:14621"
/db_xref="MIM:611772"
/translation="
METLSFPRYNVAEIVIHIRNKILTGADGKNLTKNDLYPNPKPEVLHMIYMRALQIVYGIRLEHFYMMPVNSEVMYPHLMEGFLPFSNLVTHLDSFLPICRVNDFETADILCPKAKRTSRFLSGIINFIHFREACRETYMEFLWQYKSSADKMQQLNAAHQEALMKLERLDSVPVEEQEEFKQLSDGIQELQQSLNQDFHQKTIVLQEGNSQKKSNISEKTKRLNELKLSVVSLKEIQESLKTKIVDSPEKLKNYKEKMKDTVQKLKNARQEVVEKYEIYGDSVDCLPSCQLEVQLYQKKIQDLSDNREKLASILKESLNLEDQIESDESELKKLKTEENSFKRLMIVKKEKLATAQFKINKKHEDVKQYKRTVIEDCNKVQEKRGAVYERVTTINQEIQKIKLGIQQLKDAAEREKLKSQEIFLNLKTALEKYHDGIEKAAEDSYAKIDEKTAELKRKMFKMST
"
misc_feature 301..1455
/gene="NUF2"
/gene_synonym="CDCA1; CT106; NUF2R"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q9BZD4.2);
Region: Interaction with the N-terminus of NDC80"
misc_feature 301..744
/gene="NUF2"
/gene_synonym="CDCA1; CT106; NUF2R"
/note="Nuf2 family; Region: Nuf2; pfam03800"
/db_xref="CDD:190755"
misc_feature 1039..1041
/gene="NUF2"
/gene_synonym="CDCA1; CT106; NUF2R"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 1456..1692
/gene="NUF2"
/gene_synonym="CDCA1; CT106; NUF2R"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q9BZD4.2);
Region: Interaction with the C-terminus of NDC80 and the
SPBC24-SPBC25 subcomplex"
variation 333
/gene="NUF2"
/gene_synonym="CDCA1; CT106; NUF2R"
/replace="a"
/replace="t"
/db_xref="dbSNP:138555791"
variation 342
/gene="NUF2"
/gene_synonym="CDCA1; CT106; NUF2R"
/replace="a"
/replace="t"
/db_xref="dbSNP:201923428"
variation 393
/gene="NUF2"
/gene_synonym="CDCA1; CT106; NUF2R"
/replace="c"
/replace="t"
/db_xref="dbSNP:201426055"
variation 401
/gene="NUF2"
/gene_synonym="CDCA1; CT106; NUF2R"
/replace="a"
/replace="t"
/db_xref="dbSNP:148475750"
exon 424..498
/gene="NUF2"
/gene_synonym="CDCA1; CT106; NUF2R"
/inference="alignment:Splign:1.39.8"
variation 466
/gene="NUF2"
/gene_synonym="CDCA1; CT106; NUF2R"
/replace="c"
/replace="g"
/db_xref="dbSNP:142683655"
variation 468
/gene="NUF2"
/gene_synonym="CDCA1; CT106; NUF2R"
/replace="a"
/replace="c"
/db_xref="dbSNP:16852612"
exon 499..575
/gene="NUF2"
/gene_synonym="CDCA1; CT106; NUF2R"
/inference="alignment:Splign:1.39.8"
variation 518
/gene="NUF2"
/gene_synonym="CDCA1; CT106; NUF2R"
/replace="c"
/replace="t"
/db_xref="dbSNP:149980165"
variation 558
/gene="NUF2"
/gene_synonym="CDCA1; CT106; NUF2R"
/replace="c"
/replace="t"
/db_xref="dbSNP:113602684"
variation 565
/gene="NUF2"
/gene_synonym="CDCA1; CT106; NUF2R"
/replace="a"
/replace="g"
/db_xref="dbSNP:369269006"
exon 576..637
/gene="NUF2"
/gene_synonym="CDCA1; CT106; NUF2R"
/inference="alignment:Splign:1.39.8"
variation 599
/gene="NUF2"
/gene_synonym="CDCA1; CT106; NUF2R"
/replace="a"
/replace="g"
/db_xref="dbSNP:368618280"
variation 615
/gene="NUF2"
/gene_synonym="CDCA1; CT106; NUF2R"
/replace="c"
/replace="g"
/db_xref="dbSNP:371954652"
variation 622
/gene="NUF2"
/gene_synonym="CDCA1; CT106; NUF2R"
/replace="g"
/replace="t"
/db_xref="dbSNP:142612141"
variation 630
/gene="NUF2"
/gene_synonym="CDCA1; CT106; NUF2R"
/replace="a"
/replace="g"
/db_xref="dbSNP:374014113"
exon 638..735
/gene="NUF2"
/gene_synonym="CDCA1; CT106; NUF2R"
/inference="alignment:Splign:1.39.8"
variation 647
/gene="NUF2"
/gene_synonym="CDCA1; CT106; NUF2R"
/replace="a"
/replace="g"
/db_xref="dbSNP:201079271"
variation 670
/gene="NUF2"
/gene_synonym="CDCA1; CT106; NUF2R"
/replace="a"
/replace="g"
/db_xref="dbSNP:369351164"
variation 691
/gene="NUF2"
/gene_synonym="CDCA1; CT106; NUF2R"
/replace="a"
/replace="g"
/db_xref="dbSNP:147917145"
variation 699
/gene="NUF2"
/gene_synonym="CDCA1; CT106; NUF2R"
/replace="a"
/replace="g"
/db_xref="dbSNP:141744491"
variation 703
/gene="NUF2"
/gene_synonym="CDCA1; CT106; NUF2R"
/replace="c"
/replace="t"
/db_xref="dbSNP:373198630"
variation 704
/gene="NUF2"
/gene_synonym="CDCA1; CT106; NUF2R"
/replace="a"
/replace="g"
/db_xref="dbSNP:201463150"
variation 711
/gene="NUF2"
/gene_synonym="CDCA1; CT106; NUF2R"
/replace="a"
/replace="g"
/db_xref="dbSNP:148215962"
variation 717
/gene="NUF2"
/gene_synonym="CDCA1; CT106; NUF2R"
/replace="a"
/replace="g"
/db_xref="dbSNP:369947700"
variation 735
/gene="NUF2"
/gene_synonym="CDCA1; CT106; NUF2R"
/replace="c"
/replace="t"
/db_xref="dbSNP:142235785"
exon 736..809
/gene="NUF2"
/gene_synonym="CDCA1; CT106; NUF2R"
/inference="alignment:Splign:1.39.8"
variation 746
/gene="NUF2"
/gene_synonym="CDCA1; CT106; NUF2R"
/replace="c"
/replace="t"
/db_xref="dbSNP:139996430"
variation 768
/gene="NUF2"
/gene_synonym="CDCA1; CT106; NUF2R"
/replace="c"
/replace="t"
/db_xref="dbSNP:144568103"
variation 771
/gene="NUF2"
/gene_synonym="CDCA1; CT106; NUF2R"
/replace="c"
/replace="t"
/db_xref="dbSNP:34426463"
variation 772
/gene="NUF2"
/gene_synonym="CDCA1; CT106; NUF2R"
/replace="a"
/replace="g"
/db_xref="dbSNP:61747498"
variation 786
/gene="NUF2"
/gene_synonym="CDCA1; CT106; NUF2R"
/replace="a"
/replace="g"
/db_xref="dbSNP:377474776"
variation 809
/gene="NUF2"
/gene_synonym="CDCA1; CT106; NUF2R"
/replace="a"
/replace="t"
/db_xref="dbSNP:192013645"
exon 810..906
/gene="NUF2"
/gene_synonym="CDCA1; CT106; NUF2R"
/inference="alignment:Splign:1.39.8"
variation 821
/gene="NUF2"
/gene_synonym="CDCA1; CT106; NUF2R"
/replace="c"
/replace="t"
/db_xref="dbSNP:141893601"
variation 827
/gene="NUF2"
/gene_synonym="CDCA1; CT106; NUF2R"
/replace="a"
/replace="t"
/db_xref="dbSNP:373453967"
variation 829
/gene="NUF2"
/gene_synonym="CDCA1; CT106; NUF2R"
/replace="c"
/replace="t"
/db_xref="dbSNP:376561383"
variation 858
/gene="NUF2"
/gene_synonym="CDCA1; CT106; NUF2R"
/replace="a"
/replace="t"
/db_xref="dbSNP:1509022"
variation 867
/gene="NUF2"
/gene_synonym="CDCA1; CT106; NUF2R"
/replace="a"
/replace="g"
/db_xref="dbSNP:201197914"
variation 872
/gene="NUF2"
/gene_synonym="CDCA1; CT106; NUF2R"
/replace="a"
/replace="g"
/db_xref="dbSNP:143503582"
variation 882
/gene="NUF2"
/gene_synonym="CDCA1; CT106; NUF2R"
/replace="a"
/replace="g"
/db_xref="dbSNP:370651448"
variation 896
/gene="NUF2"
/gene_synonym="CDCA1; CT106; NUF2R"
/replace="a"
/replace="c"
/db_xref="dbSNP:374285371"
variation 905
/gene="NUF2"
/gene_synonym="CDCA1; CT106; NUF2R"
/replace="c"
/replace="t"
/db_xref="dbSNP:144627000"
exon 907..969
/gene="NUF2"
/gene_synonym="CDCA1; CT106; NUF2R"
/inference="alignment:Splign:1.39.8"
variation 965
/gene="NUF2"
/gene_synonym="CDCA1; CT106; NUF2R"
/replace="a"
/replace="g"
/db_xref="dbSNP:138752079"
exon 970..1107
/gene="NUF2"
/gene_synonym="CDCA1; CT106; NUF2R"
/inference="alignment:Splign:1.39.8"
variation 978
/gene="NUF2"
/gene_synonym="CDCA1; CT106; NUF2R"
/replace="a"
/replace="g"
/db_xref="dbSNP:200859782"
variation 984
/gene="NUF2"
/gene_synonym="CDCA1; CT106; NUF2R"
/replace="g"
/replace="t"
/db_xref="dbSNP:375949382"
variation 986
/gene="NUF2"
/gene_synonym="CDCA1; CT106; NUF2R"
/replace="c"
/replace="t"
/db_xref="dbSNP:11802875"
variation 1004
/gene="NUF2"
/gene_synonym="CDCA1; CT106; NUF2R"
/replace="a"
/replace="c"
/db_xref="dbSNP:199499282"
variation 1015
/gene="NUF2"
/gene_synonym="CDCA1; CT106; NUF2R"
/replace="a"
/replace="c"
/db_xref="dbSNP:16852767"
variation 1071
/gene="NUF2"
/gene_synonym="CDCA1; CT106; NUF2R"
/replace="a"
/replace="g"
/db_xref="dbSNP:113544263"
variation 1082
/gene="NUF2"
/gene_synonym="CDCA1; CT106; NUF2R"
/replace="a"
/replace="c"
/db_xref="dbSNP:149575845"
variation 1107
/gene="NUF2"
/gene_synonym="CDCA1; CT106; NUF2R"
/replace="a"
/replace="t"
/db_xref="dbSNP:372189646"
exon 1108..1248
/gene="NUF2"
/gene_synonym="CDCA1; CT106; NUF2R"
/inference="alignment:Splign:1.39.8"
variation 1128
/gene="NUF2"
/gene_synonym="CDCA1; CT106; NUF2R"
/replace="c"
/replace="t"
/db_xref="dbSNP:200015425"
variation 1183
/gene="NUF2"
/gene_synonym="CDCA1; CT106; NUF2R"
/replace="c"
/replace="t"
/db_xref="dbSNP:201922994"
variation 1235
/gene="NUF2"
/gene_synonym="CDCA1; CT106; NUF2R"
/replace="a"
/replace="g"
/db_xref="dbSNP:375668189"
variation 1239
/gene="NUF2"
/gene_synonym="CDCA1; CT106; NUF2R"
/replace="c"
/replace="g"
/db_xref="dbSNP:148952696"
exon 1249..1424
/gene="NUF2"
/gene_synonym="CDCA1; CT106; NUF2R"
/inference="alignment:Splign:1.39.8"
variation 1266
/gene="NUF2"
/gene_synonym="CDCA1; CT106; NUF2R"
/replace="c"
/replace="t"
/db_xref="dbSNP:149167689"
variation 1284
/gene="NUF2"
/gene_synonym="CDCA1; CT106; NUF2R"
/replace="c"
/replace="g"
/db_xref="dbSNP:188255733"
variation 1320
/gene="NUF2"
/gene_synonym="CDCA1; CT106; NUF2R"
/replace="g"
/replace="t"
/db_xref="dbSNP:377218991"
variation 1321
/gene="NUF2"
/gene_synonym="CDCA1; CT106; NUF2R"
/replace="c"
/replace="t"
/db_xref="dbSNP:374182596"
variation 1325
/gene="NUF2"
/gene_synonym="CDCA1; CT106; NUF2R"
/replace="a"
/replace="g"
/db_xref="dbSNP:140857251"
variation 1340
/gene="NUF2"
/gene_synonym="CDCA1; CT106; NUF2R"
/replace="c"
/replace="t"
/db_xref="dbSNP:113047814"
variation 1386
/gene="NUF2"
/gene_synonym="CDCA1; CT106; NUF2R"
/replace="a"
/replace="g"
/db_xref="dbSNP:147464307"
variation 1410
/gene="NUF2"
/gene_synonym="CDCA1; CT106; NUF2R"
/replace="a"
/replace="g"
/db_xref="dbSNP:201201382"
variation 1411
/gene="NUF2"
/gene_synonym="CDCA1; CT106; NUF2R"
/replace="c"
/replace="t"
/db_xref="dbSNP:199764107"
exon 1425..1560
/gene="NUF2"
/gene_synonym="CDCA1; CT106; NUF2R"
/inference="alignment:Splign:1.39.8"
variation 1468
/gene="NUF2"
/gene_synonym="CDCA1; CT106; NUF2R"
/replace="c"
/replace="t"
/db_xref="dbSNP:375173490"
variation 1469
/gene="NUF2"
/gene_synonym="CDCA1; CT106; NUF2R"
/replace="a"
/replace="g"
/db_xref="dbSNP:116669228"
variation 1489
/gene="NUF2"
/gene_synonym="CDCA1; CT106; NUF2R"
/replace="a"
/replace="g"
/db_xref="dbSNP:201334528"
variation 1518
/gene="NUF2"
/gene_synonym="CDCA1; CT106; NUF2R"
/replace="a"
/replace="g"
/db_xref="dbSNP:368896054"
variation 1522
/gene="NUF2"
/gene_synonym="CDCA1; CT106; NUF2R"
/replace="c"
/replace="t"
/db_xref="dbSNP:372459343"
variation 1537
/gene="NUF2"
/gene_synonym="CDCA1; CT106; NUF2R"
/replace="c"
/replace="g"
/db_xref="dbSNP:377021975"
variation 1539
/gene="NUF2"
/gene_synonym="CDCA1; CT106; NUF2R"
/replace="a"
/replace="g"
/db_xref="dbSNP:200200000"
exon 1561..1989
/gene="NUF2"
/gene_synonym="CDCA1; CT106; NUF2R"
/inference="alignment:Splign:1.39.8"
variation 1575
/gene="NUF2"
/gene_synonym="CDCA1; CT106; NUF2R"
/replace="c"
/replace="t"
/db_xref="dbSNP:141046135"
variation 1593
/gene="NUF2"
/gene_synonym="CDCA1; CT106; NUF2R"
/replace="c"
/replace="g"
/db_xref="dbSNP:146451154"
variation 1606
/gene="NUF2"
/gene_synonym="CDCA1; CT106; NUF2R"
/replace="a"
/replace="g"
/db_xref="dbSNP:144589776"
variation 1629
/gene="NUF2"
/gene_synonym="CDCA1; CT106; NUF2R"
/replace="c"
/replace="t"
/db_xref="dbSNP:369149355"
variation 1682
/gene="NUF2"
/gene_synonym="CDCA1; CT106; NUF2R"
/replace="a"
/replace="g"
/db_xref="dbSNP:372961469"
variation 1695
/gene="NUF2"
/gene_synonym="CDCA1; CT106; NUF2R"
/replace="a"
/replace="g"
/db_xref="dbSNP:376734738"
variation 1702
/gene="NUF2"
/gene_synonym="CDCA1; CT106; NUF2R"
/replace="a"
/replace="g"
/db_xref="dbSNP:367996407"
variation 1714
/gene="NUF2"
/gene_synonym="CDCA1; CT106; NUF2R"
/replace="g"
/replace="t"
/db_xref="dbSNP:372378750"
variation 1891
/gene="NUF2"
/gene_synonym="CDCA1; CT106; NUF2R"
/replace="a"
/replace="g"
/db_xref="dbSNP:189726032"
variation 1903
/gene="NUF2"
/gene_synonym="CDCA1; CT106; NUF2R"
/replace="a"
/replace="g"
/db_xref="dbSNP:180849873"
polyA_site 1984
/gene="NUF2"
/gene_synonym="CDCA1; CT106; NUF2R"
ORIGIN
gcggaatggggcgggacttccagtaggaggcggcaagtttgaaaagtgatgacggttgacgtttgctgatttttgactttgcttgtagctgctccccgaactcgccgtcttcctgtcggcggccggcactgtaggtgagcgcgagaggacggaggaaggaagcctgcagacagacgccttctccatcccaaggcgcgggcaggtgccgggacgctgggcctggcggtgttttcgtcgtgctcagcggtgggaggaggcggaagaaaccagagcctgggagattaacaggaaacttccaagatggaaactttgtctttccccagatataatgtagctgagattgtgattcatattcgcaataagatcttaacaggagctgatggtaaaaacctcaccaagaatgatctttatccaaatccaaagcctgaagtcttgcacatgatctacatgagagccttacaaatagtatatggaattcgactggaacatttttacatgatgccagtgaactctgaagtcatgtatccacatttaatggaaggcttcttaccattcagcaatttagttactcatctggactcatttttgcctatctgccgggtgaatgactttgagactgctgatattctatgtccaaaagcaaaacggacaagtcggtttttaagtggcattatcaactttattcacttcagagaagcatgccgtgaaacgtatatggaatttctttggcaatataaatcctctgcggacaaaatgcaacagttaaacgccgcacaccaggaggcattaatgaaactggagagacttgattctgttccagttgaagagcaagaagagttcaagcagctttcagatggaattcaggagctacaacaatcactaaatcaggattttcatcaaaaaacgatagtgctgcaagagggaaattcccaaaagaagtcaaatatttcagagaaaaccaagcgtttgaatgaactaaaattgtcggtggtttctttgaaagaaatacaagagagtttgaaaacaaaaattgtggattctccagagaagttaaagaattataaagaaaaaatgaaagatacggtccagaagcttaaaaatgccagacaagaagtggtggagaaatatgaaatctatggagactcagttgactgcctgccttcatgtcagttggaagtgcagttatatcaaaagaaaatacaggacctttcagataatagggaaaaattagccagtatcttaaaggagagcctgaacttggaggaccaaattgagagtgatgagtcagaactgaagaaattgaagactgaagaaaattcgttcaaaagactgatgattgtgaagaaggaaaaacttgccacagcacaattcaaaataaataagaagcatgaagatgttaagcaatacaaacgcacagtaattgaggattgcaataaagttcaagaaaaaagaggtgctgtctatgaacgagtaaccacaattaatcaagaaatccaaaaaattaaacttggaattcaacaactaaaagatgctgctgaaagggagaaactgaagtcccaggaaatatttctaaacttgaaaactgctttggagaaataccacgacggtattgaaaaggcagcagaggactcctatgctaagatagatgagaagacagctgaactgaagaggaagatgttcaaaatgtcaacctgattaacaaaattacatgtctttttgtaaatggcttgccatcttttaattttctatttagaaagaaaagttgaagcgaatggaagtatcagaagtaccaaataatgttggcttcatcagtttttatacactctcataagtagttaataagatgaatttaatgtaggcttttattaatttataattaaaataacttgtgcagctattcatgtctctactctgccccttgttgtaaatagtttgagtaaaacaaaactagttacctttgaaatatatatatttttttctgttactatc
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:83540 -> Molecular function: GO:0003674 [molecular_function] evidence: ND
GeneID:83540 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:83540 -> Biological process: GO:0000278 [mitotic cell cycle] evidence: TAS
GeneID:83540 -> Biological process: GO:0007059 [chromosome segregation] evidence: NAS
GeneID:83540 -> Biological process: GO:0007067 [mitosis] evidence: IEA
GeneID:83540 -> Biological process: GO:0051301 [cell division] evidence: IEA
GeneID:83540 -> Cellular component: GO:0000775 [chromosome, centromeric region] evidence: NAS
GeneID:83540 -> Cellular component: GO:0000777 [condensed chromosome kinetochore] evidence: IEA
GeneID:83540 -> Cellular component: GO:0005634 [nucleus] evidence: IEA
GeneID:83540 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
GeneID:83540 -> Cellular component: GO:0031262 [Ndc80 complex] evidence: IDA
by
@meso_cacase at
DBCLS
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