GGRNA | NM_145285.2

LOCUS       NM_145285               2117 bp    mRNA    linear   PRI 15-JUN-2013
DEFINITION  Homo sapiens NK2 homeobox 3 (NKX2-3), mRNA.
ACCESSION   NM_145285
VERSION     NM_145285.2  GI:148746210
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2117)
  AUTHORS   Shaffer,J.R., Feingold,E., Wang,X., Lee,M., Tcuenco,K., Weeks,D.E.,
            Weyant,R.J., Crout,R., McNeil,D.W. and Marazita,M.L.
  TITLE     GWAS of dental caries patterns in the permanent dentition
  JOURNAL   J. Dent. Res. 92 (1), 38-44 (2013)
   PUBMED   23064961
REFERENCE   2  (bases 1 to 2117)
  AUTHORS   van der Harst,P., Zhang,W., Mateo Leach,I., Rendon,A., Verweij,N.,
            Sehmi,J., Paul,D.S., Elling,U., Allayee,H., Li,X.,
            Radhakrishnan,A., Tan,S.T., Voss,K., Weichenberger,C.X.,
            Albers,C.A., Al-Hussani,A., Asselbergs,F.W., Ciullo,M., Danjou,F.,
            Dina,C., Esko,T., Evans,D.M., Franke,L., Gogele,M., Hartiala,J.,
            Hersch,M., Holm,H., Hottenga,J.J., Kanoni,S., Kleber,M.E.,
            Lagou,V., Langenberg,C., Lopez,L.M., Lyytikainen,L.P., Melander,O.,
            Murgia,F., Nolte,I.M., O'Reilly,P.F., Padmanabhan,S., Parsa,A.,
            Pirastu,N., Porcu,E., Portas,L., Prokopenko,I., Ried,J.S.,
            Shin,S.Y., Tang,C.S., Teumer,A., Traglia,M., Ulivi,S., Westra,H.J.,
            Yang,J., Zhao,J.H., Anni,F., Abdellaoui,A., Attwood,A., Balkau,B.,
            Bandinelli,S., Bastardot,F., Benyamin,B., Boehm,B.O., Cookson,W.O.,
            Das,D., de Bakker,P.I., de Boer,R.A., de Geus,E.J., de Moor,M.H.,
            Dimitriou,M., Domingues,F.S., Doring,A., Engstrom,G.,
            Eyjolfsson,G.I., Ferrucci,L., Fischer,K., Galanello,R.,
            Garner,S.F., Genser,B., Gibson,Q.D., Girotto,G., Gudbjartsson,D.F.,
            Harris,S.E., Hartikainen,A.L., Hastie,C.E., Hedblad,B., Illig,T.,
            Jolley,J., Kahonen,M., Kema,I.P., Kemp,J.P., Liang,L.,
            Lloyd-Jones,H., Loos,R.J., Meacham,S., Medland,S.E., Meisinger,C.,
            Memari,Y., Mihailov,E., Miller,K., Moffatt,M.F., Nauck,M.,
            Novatchkova,M., Nutile,T., Olafsson,I., Onundarson,P.T.,
            Parracciani,D., Penninx,B.W., Perseu,L., Piga,A., Pistis,G.,
            Pouta,A., Puc,U., Raitakari,O., Ring,S.M., Robino,A., Ruggiero,D.,
            Ruokonen,A., Saint-Pierre,A., Sala,C., Salumets,A., Sambrook,J.,
            Schepers,H., Schmidt,C.O., Sillje,H.H., Sladek,R., Smit,J.H.,
            Starr,J.M., Stephens,J., Sulem,P., Tanaka,T., Thorsteinsdottir,U.,
            Tragante,V., van Gilst,W.H., van Pelt,L.J., van Veldhuisen,D.J.,
            Volker,U., Whitfield,J.B., Willemsen,G., Winkelmann,B.R.,
            Wirnsberger,G., Algra,A., Cucca,F., d'Adamo,A.P., Danesh,J.,
            Deary,I.J., Dominiczak,A.F., Elliott,P., Fortina,P., Froguel,P.,
            Gasparini,P., Greinacher,A., Hazen,S.L., Jarvelin,M.R., Khaw,K.T.,
            Lehtimaki,T., Maerz,W., Martin,N.G., Metspalu,A., Mitchell,B.D.,
            Montgomery,G.W., Moore,C., Navis,G., Pirastu,M., Pramstaller,P.P.,
            Ramirez-Solis,R., Schadt,E., Scott,J., Shuldiner,A.R., Smith,G.D.,
            Smith,J.G., Snieder,H., Sorice,R., Spector,T.D., Stefansson,K.,
            Stumvoll,M., Tang,W.H., Toniolo,D., Tonjes,A., Visscher,P.M.,
            Vollenweider,P., Wareham,N.J., Wolffenbuttel,B.H., Boomsma,D.I.,
            Beckmann,J.S., Dedoussis,G.V., Deloukas,P., Ferreira,M.A.,
            Sanna,S., Uda,M., Hicks,A.A., Penninger,J.M., Gieger,C.,
            Kooner,J.S., Ouwehand,W.H., Soranzo,N. and Chambers,J.C.
  TITLE     Seventy-five genetic loci influencing the human red blood cell
  JOURNAL   Nature 492 (7429), 369-375 (2012)
   PUBMED   23222517
REFERENCE   3  (bases 1 to 2117)
  AUTHORS   Jostins,L., Ripke,S., Weersma,R.K., Duerr,R.H., McGovern,D.P.,
            Hui,K.Y., Lee,J.C., Schumm,L.P., Sharma,Y., Anderson,C.A.,
            Essers,J., Mitrovic,M., Ning,K., Cleynen,I., Theatre,E.,
            Spain,S.L., Raychaudhuri,S., Goyette,P., Wei,Z., Abraham,C.,
            Achkar,J.P., Ahmad,T., Amininejad,L., Ananthakrishnan,A.N.,
            Andersen,V., Andrews,J.M., Baidoo,L., Balschun,T., Bampton,P.A.,
            Bitton,A., Boucher,G., Brand,S., Buning,C., Cohain,A., Cichon,S.,
            D'Amato,M., De Jong,D., Devaney,K.L., Dubinsky,M., Edwards,C.,
            Ellinghaus,D., Ferguson,L.R., Franchimont,D., Fransen,K.,
            Gearry,R., Georges,M., Gieger,C., Glas,J., Haritunians,T., Hart,A.,
            Hawkey,C., Hedl,M., Hu,X., Karlsen,T.H., Kupcinskas,L.,
            Kugathasan,S., Latiano,A., Laukens,D., Lawrance,I.C., Lees,C.W.,
            Louis,E., Mahy,G., Mansfield,J., Morgan,A.R., Mowat,C., Newman,W.,
            Palmieri,O., Ponsioen,C.Y., Potocnik,U., Prescott,N.J.,
            Regueiro,M., Rotter,J.I., Russell,R.K., Sanderson,J.D., Sans,M.,
            Satsangi,J., Schreiber,S., Simms,L.A., Sventoraityte,J.,
            Targan,S.R., Taylor,K.D., Tremelling,M., Verspaget,H.W., De Vos,M.,
            Wijmenga,C., Wilson,D.C., Winkelmann,J., Xavier,R.J., Zeissig,S.,
            Zhang,B., Zhang,C.K., Zhao,H., Silverberg,M.S., Annese,V.,
            Hakonarson,H., Brant,S.R., Radford-Smith,G., Mathew,C.G.,
            Rioux,J.D., Schadt,E.E., Daly,M.J., Franke,A., Parkes,M.,
            Vermeire,S., Barrett,J.C. and Cho,J.H.
  CONSRTM   International IBD Genetics Consortium (IIBDGC)
  TITLE     Host-microbe interactions have shaped the genetic architecture of
            inflammatory bowel disease
  JOURNAL   Nature 491 (7422), 119-124 (2012)
   PUBMED   23128233
REFERENCE   4  (bases 1 to 2117)
  AUTHORS   Kenny,E.E., Pe'er,I., Karban,A., Ozelius,L., Mitchell,A.A.,
            Ng,S.M., Erazo,M., Ostrer,H., Abraham,C., Abreu,M.T., Atzmon,G.,
            Barzilai,N., Brant,S.R., Bressman,S., Burns,E.R., Chowers,Y.,
            Clark,L.N., Darvasi,A., Doheny,D., Duerr,R.H., Eliakim,R.,
            Giladi,N., Gregersen,P.K., Hakonarson,H., Jones,M.R., Marder,K.,
            McGovern,D.P., Mulle,J., Orr-Urtreger,A., Proctor,D.D., Pulver,A.,
            Rotter,J.I., Silverberg,M.S., Ullman,T., Warren,S.T., Waterman,M.,
            Zhang,W., Bergman,A., Mayer,L., Katz,S., Desnick,R.J., Cho,J.H. and
            Peter,I.
  TITLE     A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests
            novel susceptibility loci
  JOURNAL   PLoS Genet. 8 (3), E1002559 (2012)
   PUBMED   22412388
REFERENCE   5  (bases 1 to 2117)
  AUTHORS   Yu,W., Hegarty,J.P., Berg,A., Kelly,A.A., Wang,Y., Poritz,L.S.,
            Franke,A., Schreiber,S., Koltun,W.A. and Lin,Z.
  TITLE     PTPN2 is associated with Crohn's disease and its expression is
            regulated by NKX2-3
  JOURNAL   Dis. Markers 32 (2), 83-91 (2012)
   PUBMED   22377701
  REMARK    GeneRIF: A positive correlation was observed between mRNA
            expression of PTPN2 and NKX2-3 in B cells and in intestinal tissues
            from both Crohn's disease and ulcerative colitis patients.
REFERENCE   6  (bases 1 to 2117)
  AUTHORS   Parkes,M., Barrett,J.C., Prescott,N.J., Tremelling,M.,
            Anderson,C.A., Fisher,S.A., Roberts,R.G., Nimmo,E.R.,
            Cummings,F.R., Soars,D., Drummond,H., Lees,C.W., Khawaja,S.A.,
            Bagnall,R., Burke,D.A., Todhunter,C.E., Ahmad,T., Onnie,C.M.,
            McArdle,W., Strachan,D., Bethel,G., Bryan,C., Lewis,C.M.,
            Deloukas,P., Forbes,A., Sanderson,J., Jewell,D.P., Satsangi,J.,
            Mansfield,J.C., Cardon,L. and Mathew,C.G.
  CONSRTM   Wellcome Trust Case Control Consortium
  TITLE     Sequence variants in the autophagy gene IRGM and multiple other
            replicating loci contribute to Crohn's disease susceptibility
  JOURNAL   Nat. Genet. 39 (7), 830-832 (2007)
   PUBMED   17554261
  REMARK    GeneRIF: Observational study and genome-wide association study of
            gene-disease association. (HuGE Navigator)
REFERENCE   7  (bases 1 to 2117)
  CONSRTM   Wellcome Trust Case Control Consortium
  TITLE     Genome-wide association study of 14,000 cases of seven common
            diseases and 3,000 shared controls
  JOURNAL   Nature 447 (7145), 661-678 (2007)
   PUBMED   17554300
REFERENCE   8  (bases 1 to 2117)
  AUTHORS   Biben,C., Wang,C.C. and Harvey,R.P.
  TITLE     NK-2 class homeobox genes and pharyngeal/oral patterning: Nkx2-3 is
            required for salivary gland and tooth morphogenesis
  JOURNAL   Int. J. Dev. Biol. 46 (4), 415-422 (2002)
   PUBMED   12141427
REFERENCE   9  (bases 1 to 2117)
  AUTHORS   Phiel,C.J., Gabbeta,V., Parsons,L.M., Rothblat,D., Harvey,R.P. and
            McHugh,K.M.
  TITLE     Differential binding of an SRF/NK-2/MEF2 transcription factor
            complex in normal versus neoplastic smooth muscle tissues
  JOURNAL   J. Biol. Chem. 276 (37), 34637-34650 (2001)
   PUBMED   11457859
REFERENCE   10 (bases 1 to 2117)
  AUTHORS   Harvey,R.P.
  TITLE     NK-2 homeobox genes and heart development
  JOURNAL   Dev. Biol. 178 (2), 203-216 (1996)
   PUBMED   8812123
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BI764885.1, BC025788.1 and
            AL353719.10.
            This sequence is a reference standard in the RefSeqGene project.
            On Jun 9, 2007 this sequence version replaced gi:21699077.
            
            Summary: This gene encodes a homeodomain-containing transcription
            factor. The encoded protein is a member of the NKX family of
            homeodomain transcription factors. Studies of similar proteins in
            mouse and rat have indicated a potential role in cellular
            differentiation.[provided by RefSeq, Mar 2010].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by orthologous data and transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BI764885.1, AK300856.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           ERS025084, ERS025088 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-20                BI764885.1         1-20
            21-1007             BC025788.1         1-987
            1008-1104           AL353719.10        7057-7153
            1105-2117           BC025788.1         988-2000
FEATURES             Location/Qualifiers
     source          1..2117
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q24.2"
     gene            1..2117
                     /gene="NKX2-3"
                     /gene_synonym="CSX3; NK2.3; NKX2.3; NKX2C; NKX4-3"
                     /note="NK2 homeobox 3"
                     /db_xref="GeneID:159296"
                     /db_xref="HGNC:7836"
                     /db_xref="MIM:606727"
     exon            1..557
                     /gene="NKX2-3"
                     /gene_synonym="CSX3; NK2.3; NKX2.3; NKX2C; NKX4-3"
                     /inference="alignment:Splign:1.39.8"
     variation       2
                     /gene="NKX2-3"
                     /gene_synonym="CSX3; NK2.3; NKX2.3; NKX2C; NKX4-3"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:59938878"
     variation       94
                     /gene="NKX2-3"
                     /gene_synonym="CSX3; NK2.3; NKX2.3; NKX2C; NKX4-3"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:186852925"
     variation       95
                     /gene="NKX2-3"
                     /gene_synonym="CSX3; NK2.3; NKX2.3; NKX2C; NKX4-3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:191738640"
     variation       117
                     /gene="NKX2-3"
                     /gene_synonym="CSX3; NK2.3; NKX2.3; NKX2C; NKX4-3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:375600503"
     variation       164
                     /gene="NKX2-3"
                     /gene_synonym="CSX3; NK2.3; NKX2.3; NKX2C; NKX4-3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:182105542"
     misc_feature    188..190
                     /gene="NKX2-3"
                     /gene_synonym="CSX3; NK2.3; NKX2.3; NKX2C; NKX4-3"
                     /note="upstream in-frame stop codon"
     CDS             200..1294
                     /gene="NKX2-3"
                     /gene_synonym="CSX3; NK2.3; NKX2.3; NKX2C; NKX4-3"
                     /note="homeobox protein NK-2 homolog C; NK2 transcription
                     factor related, locus 3"
                     /codon_start=1
                     /product="homeobox protein Nkx-2.3"
                     /protein_id="NP_660328.2"
                     /db_xref="GI:148746211"
                     /db_xref="CCDS:CCDS41558.1"
                     /db_xref="GeneID:159296"
                     /db_xref="HGNC:7836"
                     /db_xref="MIM:606727"
                     /translation="

MMLPSPVTSTPFSVKDILNLEQQHQHFHGAHLQADLEHHFHSAPCMLAAAEGTQFSDGGEEDEEDEGEKLSYLNSLAAADGHGDSGLCPQGYVHTVLRDSCSEPKEHEEEPEVVRDRSQKSCQLKKSLETAGDCKAAEESERPKPRSRRKPRVLFSQAQVFELERRFKQQRYLSAPEREHLASSLKLTSTQVKIWFQNRRYKCKRQRQDKSLELGAHAPPPPPRRVAVPVLVRDGKPCVTPSAQAYGAPYSVGASAYSYNSFPAYGYGNSAAAAAAAAAAAAAAAAYSSSYGCAYPAGGGGGGGGTSAATTAMQPACSAAGGGPFVNVSNLGGFGSGGSAQPLHQGTAAGAACAQGTLQGIRAW

"
     misc_feature    662..820
                     /gene="NKX2-3"
                     /gene_synonym="CSX3; NK2.3; NKX2.3; NKX2C; NKX4-3"
                     /note="Homeodomain;  DNA binding domains involved in the
                     transcriptional regulation of key eukaryotic developmental
                     processes; may bind to DNA as monomers or as homo- and/or
                     heterodimers, in a sequence-specific manner; Region:
                     homeodomain; cd00086"
                     /db_xref="CDD:28970"
     misc_feature    order(662..664,713..715,731..733,770..772,776..781,
                     788..793,797..805,809..814)
                     /gene="NKX2-3"
                     /gene_synonym="CSX3; NK2.3; NKX2.3; NKX2C; NKX4-3"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:28970"
     misc_feature    order(779..781,788..793,800..802)
                     /gene="NKX2-3"
                     /gene_synonym="CSX3; NK2.3; NKX2.3; NKX2C; NKX4-3"
                     /note="specific DNA base contacts [nucleotide binding];
                     other site"
                     /db_xref="CDD:28970"
     variation       225
                     /gene="NKX2-3"
                     /gene_synonym="CSX3; NK2.3; NKX2.3; NKX2C; NKX4-3"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:368583740"
     variation       268
                     /gene="NKX2-3"
                     /gene_synonym="CSX3; NK2.3; NKX2.3; NKX2C; NKX4-3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:369827413"
     variation       270
                     /gene="NKX2-3"
                     /gene_synonym="CSX3; NK2.3; NKX2.3; NKX2C; NKX4-3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:372618389"
     variation       275
                     /gene="NKX2-3"
                     /gene_synonym="CSX3; NK2.3; NKX2.3; NKX2C; NKX4-3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:376888249"
     variation       289
                     /gene="NKX2-3"
                     /gene_synonym="CSX3; NK2.3; NKX2.3; NKX2C; NKX4-3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:368978920"
     variation       315
                     /gene="NKX2-3"
                     /gene_synonym="CSX3; NK2.3; NKX2.3; NKX2C; NKX4-3"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:77050787"
     variation       325
                     /gene="NKX2-3"
                     /gene_synonym="CSX3; NK2.3; NKX2.3; NKX2C; NKX4-3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:373486169"
     variation       336
                     /gene="NKX2-3"
                     /gene_synonym="CSX3; NK2.3; NKX2.3; NKX2C; NKX4-3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:199963044"
     variation       343
                     /gene="NKX2-3"
                     /gene_synonym="CSX3; NK2.3; NKX2.3; NKX2C; NKX4-3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:372117331"
     variation       344
                     /gene="NKX2-3"
                     /gene_synonym="CSX3; NK2.3; NKX2.3; NKX2C; NKX4-3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201429667"
     variation       346
                     /gene="NKX2-3"
                     /gene_synonym="CSX3; NK2.3; NKX2.3; NKX2C; NKX4-3"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:41290504"
     variation       371
                     /gene="NKX2-3"
                     /gene_synonym="CSX3; NK2.3; NKX2.3; NKX2C; NKX4-3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:374176845"
     variation       408
                     /gene="NKX2-3"
                     /gene_synonym="CSX3; NK2.3; NKX2.3; NKX2C; NKX4-3"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:114975224"
     variation       439
                     /gene="NKX2-3"
                     /gene_synonym="CSX3; NK2.3; NKX2.3; NKX2C; NKX4-3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:145887258"
     variation       446
                     /gene="NKX2-3"
                     /gene_synonym="CSX3; NK2.3; NKX2.3; NKX2C; NKX4-3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200446284"
     variation       452
                     /gene="NKX2-3"
                     /gene_synonym="CSX3; NK2.3; NKX2.3; NKX2C; NKX4-3"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:370885897"
     variation       533
                     /gene="NKX2-3"
                     /gene_synonym="CSX3; NK2.3; NKX2.3; NKX2C; NKX4-3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:373715351"
     exon            558..2097
                     /gene="NKX2-3"
                     /gene_synonym="CSX3; NK2.3; NKX2.3; NKX2C; NKX4-3"
                     /inference="alignment:Splign:1.39.8"
     variation       589
                     /gene="NKX2-3"
                     /gene_synonym="CSX3; NK2.3; NKX2.3; NKX2C; NKX4-3"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:367821133"
     variation       632
                     /gene="NKX2-3"
                     /gene_synonym="CSX3; NK2.3; NKX2.3; NKX2C; NKX4-3"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:79873574"
     variation       655
                     /gene="NKX2-3"
                     /gene_synonym="CSX3; NK2.3; NKX2.3; NKX2C; NKX4-3"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:374871429"
     variation       667
                     /gene="NKX2-3"
                     /gene_synonym="CSX3; NK2.3; NKX2.3; NKX2C; NKX4-3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:184601313"
     variation       752
                     /gene="NKX2-3"
                     /gene_synonym="CSX3; NK2.3; NKX2.3; NKX2C; NKX4-3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:113459553"
     variation       781
                     /gene="NKX2-3"
                     /gene_synonym="CSX3; NK2.3; NKX2.3; NKX2C; NKX4-3"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:78122843"
     variation       813
                     /gene="NKX2-3"
                     /gene_synonym="CSX3; NK2.3; NKX2.3; NKX2C; NKX4-3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:369954020"
     variation       852
                     /gene="NKX2-3"
                     /gene_synonym="CSX3; NK2.3; NKX2.3; NKX2C; NKX4-3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:372919519"
     variation       959
                     /gene="NKX2-3"
                     /gene_synonym="CSX3; NK2.3; NKX2.3; NKX2C; NKX4-3"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:200509540"
     variation       1012
                     /gene="NKX2-3"
                     /gene_synonym="CSX3; NK2.3; NKX2.3; NKX2C; NKX4-3"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:59754112"
     variation       1018
                     /gene="NKX2-3"
                     /gene_synonym="CSX3; NK2.3; NKX2.3; NKX2C; NKX4-3"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:60505509"
     variation       1021
                     /gene="NKX2-3"
                     /gene_synonym="CSX3; NK2.3; NKX2.3; NKX2C; NKX4-3"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:59941155"
     variation       1042
                     /gene="NKX2-3"
                     /gene_synonym="CSX3; NK2.3; NKX2.3; NKX2C; NKX4-3"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:10082511"
     variation       1272
                     /gene="NKX2-3"
                     /gene_synonym="CSX3; NK2.3; NKX2.3; NKX2C; NKX4-3"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:151053941"
     STS             1397..2077
                     /gene="NKX2-3"
                     /gene_synonym="CSX3; NK2.3; NKX2.3; NKX2C; NKX4-3"
                     /standard_name="NKX2-3_1975"
                     /db_xref="UniSTS:463269"
     variation       1469..1470
                     /gene="NKX2-3"
                     /gene_synonym="CSX3; NK2.3; NKX2.3; NKX2C; NKX4-3"
                     /replace=""
                     /replace="a"
                     /db_xref="dbSNP:5787350"
     variation       1471
                     /gene="NKX2-3"
                     /gene_synonym="CSX3; NK2.3; NKX2.3; NKX2C; NKX4-3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:199863832"
     variation       1531
                     /gene="NKX2-3"
                     /gene_synonym="CSX3; NK2.3; NKX2.3; NKX2C; NKX4-3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:368108882"
     variation       1585
                     /gene="NKX2-3"
                     /gene_synonym="CSX3; NK2.3; NKX2.3; NKX2C; NKX4-3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:141309484"
     variation       1679
                     /gene="NKX2-3"
                     /gene_synonym="CSX3; NK2.3; NKX2.3; NKX2C; NKX4-3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:888208"
     variation       1748
                     /gene="NKX2-3"
                     /gene_synonym="CSX3; NK2.3; NKX2.3; NKX2C; NKX4-3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:7906496"
     variation       1783
                     /gene="NKX2-3"
                     /gene_synonym="CSX3; NK2.3; NKX2.3; NKX2C; NKX4-3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:374205970"
     variation       1790
                     /gene="NKX2-3"
                     /gene_synonym="CSX3; NK2.3; NKX2.3; NKX2C; NKX4-3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:145068124"
     variation       1815
                     /gene="NKX2-3"
                     /gene_synonym="CSX3; NK2.3; NKX2.3; NKX2C; NKX4-3"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:138803080"
     variation       1837
                     /gene="NKX2-3"
                     /gene_synonym="CSX3; NK2.3; NKX2.3; NKX2C; NKX4-3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:141988959"
     variation       1845
                     /gene="NKX2-3"
                     /gene_synonym="CSX3; NK2.3; NKX2.3; NKX2C; NKX4-3"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:188570312"
     variation       1908
                     /gene="NKX2-3"
                     /gene_synonym="CSX3; NK2.3; NKX2.3; NKX2C; NKX4-3"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:7906748"
     variation       1913
                     /gene="NKX2-3"
                     /gene_synonym="CSX3; NK2.3; NKX2.3; NKX2C; NKX4-3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:78952335"
     variation       1956
                     /gene="NKX2-3"
                     /gene_synonym="CSX3; NK2.3; NKX2.3; NKX2C; NKX4-3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:181369263"
     variation       2000..2001
                     /gene="NKX2-3"
                     /gene_synonym="CSX3; NK2.3; NKX2.3; NKX2C; NKX4-3"
                     /replace=""
                     /replace="tatc"
                     /db_xref="dbSNP:376401553"
     polyA_signal    2072..2077
                     /gene="NKX2-3"
                     /gene_synonym="CSX3; NK2.3; NKX2.3; NKX2C; NKX4-3"
     polyA_site      2097
                     /gene="NKX2-3"
                     /gene_synonym="CSX3; NK2.3; NKX2.3; NKX2C; NKX4-3"
ORIGIN

agtccctgcagtggctgtaacaaaacccagacccccaggtcccggccaatggaggcgatttagactggagtgggaccgcgtctgtcaaaagcccgactcggcagcagcggcggagtccaggaggagagctggagccgccgcgctgcctccccgcccccgccgggatttattatttggactggacaattaagtggccctgatgatgttaccaagcccggtcacctccacccctttctcagtcaaagacattttgaatctggagcagcagcaccagcacttccatggtgcgcacttgcaggcggacttggagcaccacttccactctgcgccctgcatgctggccgccgctgaggggacgcaattttctgacggaggggaggaggacgaggaagacgagggcgagaaattgtcctatttgaactcactagccgcagcagacggccacggggattcagggctgtgtccccagggctatgtccacacggtcctgcgagactcgtgcagcgagcccaaggaacatgaagaggagcccgaggtcgtgagggaccggagccaaaaaagctgccagctgaagaagtctctagagacggccggagactgcaaggcggcggaggagagcgagaggccgaagccacgcagccgccggaagccccgggtcctcttctcgcaagcccaggtcttcgagctggaacgcaggttcaagcagcagcggtacctgtcggcacccgagcgcgagcacctcgccagcagcctgaagctcacatccactcaggtgaaaatctggttccagaatcgcaggtacaagtgcaagagacagcggcaggacaagtctctggagcttggcgcacacgcgcccccgccgccgccgcgccgcgtggctgtcccggtgctggtgcgggacggcaagccgtgcgtcacgcccagcgcgcaggcctacggcgcgccctacagcgtgggcgccagcgcctactcctacaacagcttccccgcctacggctatgggaactcggccgcggccgccgccgccgccgccgccgccgccgcagcagcggcggcctacagcagcagctatggctgtgcgtacccggcgggcggcggcggcggcggcggcgggacctccgcggcgaccactgccatgcagcccgcctgcagcgcggccggaggcggcccctttgtgaacgtgagcaacctaggaggcttcggcagcggcggcagcgcacagccgttgcaccagggtactgcagccggggccgcgtgcgctcagggcaccttgcagggcatccgggcctggtagggacggggcgggtcacgcggcgggcaccccagcgcagcctggcgccgcgggactgaagctcgagaagggcctgacctaaaggtcaggtcccctcgttaaaaaaatatgtacgtctagctcctcagggcttcggatcgcagctcactcgaggcctggggaaggggactcaggggcgaggaggatgactgggtccggtcgccaggactgtctctgaggcagaaacgccggctgggcgccggggaggacgatggccccgaccctggcagcgagaggagaccaggaggctaggaccctggccgcgcttggttcttccaaagcgagaagggcttctctccctctgcctttccgcggcctccgcgaagcgttggcggggagcccaaggacataacaaattaaaagcatgaaggagagaaaaatgggggtcgtggcttgagaaattccaggccctaccgatcctctgccccctttgcgggcctggagcgccatagcacagtcgatttcgtttcgcagctgtctcccctccgcagcagatacctcggtccagatctccggattgtcgggggacgcaggactcttcgaggaaaaccagccgaatgagatcaaaagttgggggtggggggaggctgaacaaactcaggacctggtggcccaccggaggtgttaccgggtttcctttctgtttcgtattctgtattcagcacatgttatctatctatctatctatataactataaccacacgccgtgtagacacccgctgccacacactacaggagtcaataaacaaggtgcaatattttcaaaaaaaaaaaaaaaaaaaaaaa

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