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2024-04-25 22:05:18, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_134323 1888 bp mRNA linear PRI 07-JUL-2013
DEFINITION Homo sapiens TAR (HIV-1) RNA binding protein 2 (TARBP2), transcript
variant 1, mRNA.
ACCESSION NM_134323
VERSION NM_134323.1 GI:19743839
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1888)
AUTHORS Redfern,A.D., Colley,S.M., Beveridge,D.J., Ikeda,N., Epis,M.R.,
Li,X., Foulds,C.E., Stuart,L.M., Barker,A., Russell,V.J.,
Ramsay,K., Kobelke,S.J., Li,X., Hatchell,E.C., Payne,C.,
Giles,K.M., Messineo,A., Gatignol,A., Lanz,R.B., O'Malley,B.W. and
Leedman,P.J.
TITLE RNA-induced silencing complex (RISC) Proteins PACT, TRBP, and Dicer
are SRA binding nuclear receptor coregulators
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 110 (16), 6536-6541 (2013)
PUBMED 23550157
REMARK GeneRIF: RISC proteins PACT, TRBP, and Dicer, together with PKR,
are steroid receptor RNA activator-binding nuclear receptor
coregulators that are recruited to the promoters of
hormone-regulated genes and regulate the expression of downstream
target genes.
REFERENCE 2 (bases 1 to 1888)
AUTHORS Benoit,M.P., Imbert,L., Palencia,A., Perard,J., Ebel,C.,
Boisbouvier,J. and Plevin,M.J.
TITLE The RNA-binding region of human TRBP interacts with microRNA
precursors through two independent domains
JOURNAL Nucleic Acids Res. 41 (7), 4241-4252 (2013)
PUBMED 23435228
REMARK GeneRIF: Results show that the region of TRBP that binds immature
miRNAs comprises two independent double-stranded RNA-binding
domains connected by a 60-residue flexible linker.
REFERENCE 3 (bases 1 to 1888)
AUTHORS Koh,H.R., Kidwell,M.A., Ragunathan,K., Doudna,J.A. and Myong,S.
TITLE ATP-independent diffusion of double-stranded RNA binding proteins
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 110 (1), 151-156 (2013)
PUBMED 23251028
REMARK GeneRIF: We report an unanticipated dsRNA diffusion behavior of
TRBP, which requires two double-stranded RNA binding domains, and
its correlation with the role of TRBP in promoting Dicer-induced
RNA cleavage.
REFERENCE 4 (bases 1 to 1888)
AUTHORS Zhang,C., Huys,A., Thibault,P.A. and Wilson,J.A.
TITLE Requirements for human Dicer and TRBP in microRNA-122 regulation of
HCV translation and RNA abundance
JOURNAL Virology 433 (2), 479-488 (2012)
PUBMED 22999255
REMARK GeneRIF: Depletion of Dicer and TRBP, proteins involved in miRNA
biogenesis, reduced HCV RNA accumulation, mature duplex miR-122
abundance, and miR-122 directed mRNA translation suppression,
suggesting roles in miR-122 processing.
REFERENCE 5 (bases 1 to 1888)
AUTHORS Lee,H.Y. and Doudna,J.A.
TITLE TRBP alters human precursor microRNA processing in vitro
JOURNAL RNA 18 (11), 2012-2019 (2012)
PUBMED 23006623
REMARK GeneRIF: TRBP is a key regulator of miRNA processing and targeting
in humans.
REFERENCE 6 (bases 1 to 1888)
AUTHORS Gatignol,A., Duarte,M., Daviet,L., Chang,Y.N. and Jeang,K.T.
TITLE Sequential steps in Tat trans-activation of HIV-1 mediated through
cellular DNA, RNA, and protein binding factors
JOURNAL Gene Expr. 5 (4-5), 217-228 (1996)
PUBMED 8723388
REFERENCE 7 (bases 1 to 1888)
AUTHORS Cosentino,G.P., Venkatesan,S., Serluca,F.C., Green,S.R.,
Mathews,M.B. and Sonenberg,N.
TITLE Double-stranded-RNA-dependent protein kinase and TAR RNA-binding
protein form homo- and heterodimers in vivo
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 92 (21), 9445-9449 (1995)
PUBMED 7568151
REFERENCE 8 (bases 1 to 1888)
AUTHORS Kozak,C.A., Gatignol,A., Graham,K., Jeang,K.T. and McBride,O.W.
TITLE Genetic mapping in human and mouse of the locus encoding TRBP, a
protein that binds the TAR region of the human immunodeficiency
virus (HIV-1)
JOURNAL Genomics 25 (1), 66-72 (1995)
PUBMED 7774957
REFERENCE 9 (bases 1 to 1888)
AUTHORS Gatignol,A., Buckler,C. and Jeang,K.T.
TITLE Relatedness of an RNA-binding motif in human immunodeficiency virus
type 1 TAR RNA-binding protein TRBP to human P1/dsI kinase and
Drosophila staufen
JOURNAL Mol. Cell. Biol. 13 (4), 2193-2202 (1993)
PUBMED 8455607
REFERENCE 10 (bases 1 to 1888)
AUTHORS Gatignol,A., Buckler-White,A., Berkhout,B. and Jeang,K.T.
TITLE Characterization of a human TAR RNA-binding protein that activates
the HIV-1 LTR
JOURNAL Science 251 (5001), 1597-1600 (1991)
PUBMED 2011739
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from BC002419.2 and BC005860.2.
Summary: HIV-1, the causative agent of acquired immunodeficiency
syndrome (AIDS), contains an RNA genome that produces a
chromosomally integrated DNA during the replicative cycle.
Activation of HIV-1 gene expression by the transactivator Tat is
dependent on an RNA regulatory element (TAR) located downstream of
the transcription initiation site. The protein encoded by this gene
binds between the bulge and the loop of the HIV-1 TAR RNA
regulatory element and activates HIV-1 gene expression in synergy
with the viral Tat protein. Alternative splicing results in
multiple transcript variants encoding different isoforms. This gene
also has a pseudogene. [provided by RefSeq, Jul 2008].
Transcript Variant: This variant (1) is the longer transcript and
encodes the longer isoform (a).
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: BC005860.2, U08998.2 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025081, ERS025084 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-814 BC002419.2 1-814
815-1888 BC005860.2 680-1753
FEATURES Location/Qualifiers
source 1..1888
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="12"
/map="12q12-q13"
gene 1..1888
/gene="TARBP2"
/gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
/note="TAR (HIV-1) RNA binding protein 2"
/db_xref="GeneID:6895"
/db_xref="HGNC:11569"
/db_xref="HPRD:05446"
/db_xref="MIM:605053"
exon 1..541
/gene="TARBP2"
/gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
/inference="alignment:Splign:1.39.8"
variation 96
/gene="TARBP2"
/gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
/replace="a"
/replace="g"
/db_xref="dbSNP:1564873"
variation 135
/gene="TARBP2"
/gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
/replace="a"
/replace="t"
/db_xref="dbSNP:369719479"
variation 185
/gene="TARBP2"
/gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
/replace="c"
/replace="g"
/db_xref="dbSNP:2139776"
variation 230
/gene="TARBP2"
/gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
/replace="a"
/replace="g"
/db_xref="dbSNP:143706116"
variation 257
/gene="TARBP2"
/gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
/replace="g"
/replace="t"
/db_xref="dbSNP:147153178"
variation 277
/gene="TARBP2"
/gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
/replace="a"
/replace="g"
/db_xref="dbSNP:374106692"
misc_feature 417..419
/gene="TARBP2"
/gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
/note="upstream in-frame stop codon"
variation 435
/gene="TARBP2"
/gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
/replace="c"
/replace="t"
/db_xref="dbSNP:372620817"
variation 486
/gene="TARBP2"
/gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
/replace="a"
/replace="g"
/db_xref="dbSNP:367720214"
CDS 489..1589
/gene="TARBP2"
/gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
/note="isoform a is encoded by transcript variant 1; TAR
(HIV) RNA-binding protein 2; TAR (HIV) RNA binding protein
2; TAR RNA-binding protein 2; trans-activation responsive
RNA-binding protein; TAR RNA binding protein 2;
RISC-loading complex subunit TARBP2; TAR (HIV) RNA-binding
protein TRBP1; trans-activation-responsive RNA-binding
protein"
/codon_start=1
/product="RISC-loading complex subunit TARBP2 isoform a"
/protein_id="NP_599150.1"
/db_xref="GI:19743840"
/db_xref="CCDS:CCDS8861.1"
/db_xref="GeneID:6895"
/db_xref="HGNC:11569"
/db_xref="HPRD:05446"
/db_xref="MIM:605053"
/translation="
MSEEEQGSGTTTGCGLPSIEQMLAANPGKTPISLLQEYGTRIGKTPVYDLLKAEGQAHQPNFTFRVTVGDTSCTGQGPSKKAAKHKAAEVALKHLKGGSMLEPALEDSSSFSPLDSSLPEDIPVFTAAAAATPVPSVVLTRSPPMELQPPVSPQQSECNPVGALQELVVQKGWRLPEYTVTQESGPAHRKEFTMTCRVERFIEIGSGTSKKLAKRNAAAKMLLRVHTVPLDARDGNEVEPDDDHFSIGVGSRLDGLRNRGPGCTWDSLRNSVGEKILSLRSCSLGSLGALGPACCRVLSELSEEQAFHVSYLDIEELSLSGLCQCLVELSTQPATVCHGSATTREAARGEAARRALQYLKIMAGSK
"
misc_feature 552..803
/gene="TARBP2"
/gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q15633.3);
Region: Sufficient for interaction with PRKRA"
misc_feature 576..>725
/gene="TARBP2"
/gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
/note="Double-stranded RNA binding motif. Binding is not
sequence specific but is highly specific for double
stranded RNA. Found in a variety of proteins including
dsRNA dependent protein kinase PKR, RNA helicases,
Drosophila staufen protein, E. coli RNase III; Region:
DSRM; cd00048"
/db_xref="CDD:28930"
misc_feature order(576..578,594..599,720..725)
/gene="TARBP2"
/gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
/note="dsRNA binding site [nucleotide binding]; other
site"
/db_xref="CDD:28930"
misc_feature 942..1190
/gene="TARBP2"
/gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q15633.3);
Region: Sufficient for interaction with PRKRA"
misc_feature 963..1154
/gene="TARBP2"
/gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
/note="Double-stranded RNA binding motif. Binding is not
sequence specific but is highly specific for double
stranded RNA. Found in a variety of proteins including
dsRNA dependent protein kinase PKR, RNA helicases,
Drosophila staufen protein, E. coli RNase III; Region:
DSRM; cd00048"
/db_xref="CDD:28930"
misc_feature order(963..965,981..986,1110..1121,1128..1130)
/gene="TARBP2"
/gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
/note="dsRNA binding site [nucleotide binding]; other
site"
/db_xref="CDD:28930"
misc_feature 1170..1586
/gene="TARBP2"
/gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q15633.3);
Region: Sufficient for interaction with DICER1"
misc_feature 1347..1586
/gene="TARBP2"
/gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q15633.3);
Region: Sufficient for interaction with PRKRA"
variation 530
/gene="TARBP2"
/gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
/replace="c"
/replace="g"
/db_xref="dbSNP:371506572"
variation 532
/gene="TARBP2"
/gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
/replace="a"
/replace="g"
/db_xref="dbSNP:374991961"
variation 535
/gene="TARBP2"
/gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
/replace="c"
/replace="t"
/db_xref="dbSNP:148956859"
exon 542..711
/gene="TARBP2"
/gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
/inference="alignment:Splign:1.39.8"
variation 562
/gene="TARBP2"
/gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
/replace="c"
/replace="t"
/db_xref="dbSNP:143690659"
variation 567
/gene="TARBP2"
/gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
/replace="c"
/replace="t"
/db_xref="dbSNP:201806294"
variation 572
/gene="TARBP2"
/gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
/replace="a"
/replace="c"
/db_xref="dbSNP:138314225"
variation 580
/gene="TARBP2"
/gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
/replace="c"
/replace="t"
/db_xref="dbSNP:372439760"
variation 612
/gene="TARBP2"
/gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
/replace="a"
/replace="g"
/db_xref="dbSNP:200955588"
variation 647
/gene="TARBP2"
/gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
/replace="c"
/replace="t"
/db_xref="dbSNP:143814054"
variation 673
/gene="TARBP2"
/gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
/replace="a"
/replace="t"
/db_xref="dbSNP:374404200"
variation 688
/gene="TARBP2"
/gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
/replace="c"
/replace="t"
/db_xref="dbSNP:368515319"
exon 712..814
/gene="TARBP2"
/gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
/inference="alignment:Splign:1.39.8"
variation 778
/gene="TARBP2"
/gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
/replace="c"
/replace="g"
/db_xref="dbSNP:146234229"
variation 779
/gene="TARBP2"
/gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
/replace="g"
/replace="t"
/db_xref="dbSNP:138922911"
exon 815..910
/gene="TARBP2"
/gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
/inference="alignment:Splign:1.39.8"
variation 833
/gene="TARBP2"
/gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
/replace="c"
/replace="g"
/db_xref="dbSNP:375489701"
variation 839
/gene="TARBP2"
/gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
/replace="a"
/replace="g"
/db_xref="dbSNP:141294828"
variation 874
/gene="TARBP2"
/gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
/replace="c"
/replace="g"
/db_xref="dbSNP:183009410"
variation 896
/gene="TARBP2"
/gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
/replace="a"
/replace="t"
/db_xref="dbSNP:371431074"
exon 911..983
/gene="TARBP2"
/gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
/inference="alignment:Splign:1.39.8"
variation 916
/gene="TARBP2"
/gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
/replace="c"
/replace="g"
/db_xref="dbSNP:150772647"
variation 917
/gene="TARBP2"
/gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
/replace="c"
/replace="t"
/db_xref="dbSNP:374358069"
variation 918
/gene="TARBP2"
/gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
/replace="c"
/replace="t"
/db_xref="dbSNP:139126157"
variation 919
/gene="TARBP2"
/gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
/replace="c"
/replace="g"
/db_xref="dbSNP:374557769"
variation 940
/gene="TARBP2"
/gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
/replace="c"
/replace="t"
/db_xref="dbSNP:149488319"
variation 963..964
/gene="TARBP2"
/gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
/replace=""
/replace="aa"
/db_xref="dbSNP:71687518"
variation 968
/gene="TARBP2"
/gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
/replace="c"
/replace="t"
/db_xref="dbSNP:145961214"
exon 984..1101
/gene="TARBP2"
/gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
/inference="alignment:Splign:1.39.8"
variation 986
/gene="TARBP2"
/gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
/replace="a"
/replace="g"
/db_xref="dbSNP:139830544"
variation 1016
/gene="TARBP2"
/gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
/replace="a"
/replace="g"
/db_xref="dbSNP:200766710"
variation 1023
/gene="TARBP2"
/gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
/replace="a"
/replace="c"
/db_xref="dbSNP:199668545"
variation 1051
/gene="TARBP2"
/gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
/replace="a"
/replace="c"
/db_xref="dbSNP:3203547"
variation 1077
/gene="TARBP2"
/gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
/replace="a"
/replace="c"
/db_xref="dbSNP:140420856"
variation 1082
/gene="TARBP2"
/gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
/replace="a"
/replace="g"
/db_xref="dbSNP:377165322"
exon 1102..1229
/gene="TARBP2"
/gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
/inference="alignment:Splign:1.39.8"
variation 1103
/gene="TARBP2"
/gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
/replace="a"
/replace="g"
/db_xref="dbSNP:200876264"
variation 1142
/gene="TARBP2"
/gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
/replace="a"
/replace="g"
/db_xref="dbSNP:190258088"
variation 1143
/gene="TARBP2"
/gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
/replace="g"
/replace="t"
/db_xref="dbSNP:368267516"
variation 1160
/gene="TARBP2"
/gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
/replace="a"
/replace="g"
/db_xref="dbSNP:370797559"
variation 1166
/gene="TARBP2"
/gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
/replace="c"
/replace="t"
/db_xref="dbSNP:146166955"
variation 1169
/gene="TARBP2"
/gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
/replace="a"
/replace="g"
/db_xref="dbSNP:112692079"
variation 1185
/gene="TARBP2"
/gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
/replace="c"
/replace="t"
/db_xref="dbSNP:148798022"
exon 1230..1431
/gene="TARBP2"
/gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
/inference="alignment:Splign:1.39.8"
variation 1240
/gene="TARBP2"
/gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
/replace="c"
/replace="t"
/db_xref="dbSNP:1126500"
variation 1277
/gene="TARBP2"
/gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
/replace="c"
/replace="t"
/db_xref="dbSNP:369459694"
variation 1313
/gene="TARBP2"
/gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
/replace="a"
/replace="g"
/db_xref="dbSNP:374237346"
variation 1374
/gene="TARBP2"
/gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
/replace="c"
/replace="t"
/db_xref="dbSNP:202227515"
variation 1412
/gene="TARBP2"
/gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
/replace="c"
/replace="t"
/db_xref="dbSNP:370082621"
variation 1430
/gene="TARBP2"
/gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
/replace="c"
/replace="t"
/db_xref="dbSNP:61499963"
exon 1432..1872
/gene="TARBP2"
/gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
/inference="alignment:Splign:1.39.8"
variation 1486
/gene="TARBP2"
/gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
/replace="c"
/replace="t"
/db_xref="dbSNP:372769309"
variation 1488
/gene="TARBP2"
/gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
/replace="a"
/replace="g"
/db_xref="dbSNP:151303646"
STS 1491..1863
/gene="TARBP2"
/gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
/standard_name="TARBP2__5191"
/db_xref="UniSTS:466499"
variation 1549
/gene="TARBP2"
/gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
/replace="a"
/replace="g"
/db_xref="dbSNP:140535249"
STS 1564..1728
/gene="TARBP2"
/gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
/standard_name="STS-R72841"
/db_xref="UniSTS:67883"
STS 1590..1864
/gene="TARBP2"
/gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
/standard_name="G42930"
/db_xref="UniSTS:13350"
STS 1596..1791
/gene="TARBP2"
/gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
/standard_name="STS-M60801"
/db_xref="UniSTS:14039"
variation 1615
/gene="TARBP2"
/gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
/replace="c"
/replace="t"
/db_xref="dbSNP:376072604"
variation 1623
/gene="TARBP2"
/gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
/replace="g"
/replace="t"
/db_xref="dbSNP:201937693"
variation 1626
/gene="TARBP2"
/gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
/replace="c"
/replace="t"
/db_xref="dbSNP:371130451"
variation 1633
/gene="TARBP2"
/gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
/replace="c"
/replace="g"
/db_xref="dbSNP:375653873"
variation 1647
/gene="TARBP2"
/gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
/replace="a"
/replace="g"
/db_xref="dbSNP:2531"
STS 1716..1858
/gene="TARBP2"
/gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
/standard_name="RH39878"
/db_xref="UniSTS:88059"
variation 1780
/gene="TARBP2"
/gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
/replace="c"
/replace="t"
/db_xref="dbSNP:138108626"
variation 1781
/gene="TARBP2"
/gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
/replace="a"
/replace="g"
/db_xref="dbSNP:117830235"
variation 1799
/gene="TARBP2"
/gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
/replace="a"
/replace="g"
/db_xref="dbSNP:143775286"
variation 1827
/gene="TARBP2"
/gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
/replace="c"
/replace="t"
/db_xref="dbSNP:185547953"
polyA_signal 1844..1849
/gene="TARBP2"
/gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
variation 1856
/gene="TARBP2"
/gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
/replace="a"
/replace="g"
/db_xref="dbSNP:73313239"
polyA_site 1872
/gene="TARBP2"
/gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
ORIGIN
gcctctccagctgcgacacagatggcgcgcgggctcttgggttctgtagttttctcgcgatccaaaaggctccgtgcccaagtgagtccttaccgcctccctacccagcggcttcccctccgctagtacgcatgtccacagcttcacggaccgggagagagggggcgcggaaggaaggaggcgggacggtattacaaacaaaaaaatacggccttctcgagaagcgacggcggagggcccgctcctcccagaaggcggtgcagcctgcccgggcgagccacgcacgcagagggttgtggggcggatagctcccctccagatggaggctcacgaagtagggtgggcgggggactccatatcccagcgtgccccgcggcgggccctaccggccgcgactccgggcttggccccggccctagctcgtcggctgtgtattggggcgcgtggaggctgcagtcacggtggcgcccgcggggacggaggagggaatgagtgaagaggagcaaggctccggcactaccacgggctgcgggctgcctagtatagagcaaatgctggccgccaacccaggcaagaccccgatcagccttctgcaggagtatgggaccagaatagggaagacgcctgtgtacgaccttctcaaagccgagggccaagcccaccagcctaatttcaccttccgggtcaccgttggcgacaccagctgcactggtcagggccccagcaagaaggcagccaagcacaaggcagctgaggtggccctcaaacacctcaaaggggggagcatgctggagccggccctggaggacagcagttctttttctcccctagactcttcactgcctgaggacattccggtttttactgctgcagcagctgctaccccagttccatctgtagtcctaaccaggagcccccccatggaactgcagccccctgtctcccctcagcagtctgagtgcaaccccgttggtgctctgcaggagctggtggtgcagaaaggctggcggttgccggagtacacagtgacccaggagtctgggccagcccaccgcaaagaattcaccatgacctgtcgagtggagcgtttcattgagattgggagtggcacttccaaaaaattggcaaagcggaatgcggcggccaaaatgctgcttcgagtgcacacggtgcctctggatgcccgggatggcaatgaggtggagcctgatgatgaccacttctccattggtgtgggctcccgcctggatggtcttcgaaaccggggcccaggttgcacctgggattctctacgaaattcagtaggagagaagatcctgtccctccgcagttgctccctgggctccctgggtgccctgggccctgcctgctgccgtgtcctcagtgagctctctgaggagcaggcctttcacgtcagctacctggatattgaggagctgagcctgagtggactctgccagtgcctggtggaactgtccacccagccggccactgtgtgtcatggctctgcaaccaccagggaggcagcccgtggtgaggctgcccgccgtgccctgcagtacctcaagatcatggcaggcagcaagtgaagccccagctggactcatggatgtgcaccctttgctccctgctctttctgcctctgggctcatgtatctgcgcagctctggtaccctctgtgggtgccatctctacctctgacacagactgcctgccttgaagctgagaaggcacagggcaaggagccaaggaccacagagcctcagccagcccaggatccgtcctcattttattggtgatgatgaatgggaatgaaatcagggggctgtctactagagcctggaataaatatgctgctttgtggatttttaaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:6895 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:6895 -> Molecular function: GO:0035197 [siRNA binding] evidence: IDA
GeneID:6895 -> Molecular function: GO:0042803 [protein homodimerization activity] evidence: IPI
GeneID:6895 -> Biological process: GO:0006355 [regulation of transcription, DNA-dependent] evidence: TAS
GeneID:6895 -> Biological process: GO:0006357 [regulation of transcription from RNA polymerase II promoter] evidence: TAS
GeneID:6895 -> Biological process: GO:0006417 [regulation of translation] evidence: IEA
GeneID:6895 -> Biological process: GO:0006469 [negative regulation of protein kinase activity] evidence: TAS
GeneID:6895 -> Biological process: GO:0010467 [gene expression] evidence: TAS
GeneID:6895 -> Biological process: GO:0030422 [production of siRNA involved in RNA interference] evidence: IDA
GeneID:6895 -> Biological process: GO:0030423 [targeting of mRNA for destruction involved in RNA interference] evidence: IMP
GeneID:6895 -> Biological process: GO:0031054 [pre-miRNA processing] evidence: IDA
GeneID:6895 -> Biological process: GO:0035280 [miRNA loading onto RISC involved in gene silencing by miRNA] evidence: IDA
GeneID:6895 -> Biological process: GO:0045070 [positive regulation of viral genome replication] evidence: IDA
GeneID:6895 -> Biological process: GO:0046782 [regulation of viral transcription] evidence: IDA
GeneID:6895 -> Biological process: GO:0050689 [negative regulation of defense response to virus by host] evidence: IDA
GeneID:6895 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
GeneID:6895 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA
GeneID:6895 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
GeneID:6895 -> Cellular component: GO:0016442 [RNA-induced silencing complex] evidence: IDA
GeneID:6895 -> Cellular component: GO:0048471 [perinuclear region of cytoplasm] evidence: IEA
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@meso_cacase at
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