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2024-04-24 08:07:21, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_053026 7645 bp mRNA linear PRI 17-APR-2013
DEFINITION Homo sapiens myosin light chain kinase (MYLK), transcript variant
2, mRNA.
ACCESSION NM_053026
VERSION NM_053026.3 GI:116008187
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 7645)
AUTHORS Usatyuk,P.V., Singleton,P.A., Pendyala,S., Kalari,S.K., He,D.,
Gorshkova,I.A., Camp,S.M., Moitra,J., Dudek,S.M., Garcia,J.G. and
Natarajan,V.
TITLE Novel role for non-muscle myosin light chain kinase (MLCK) in
hyperoxia-induced recruitment of cytoskeletal proteins, NADPH
oxidase activation, and reactive oxygen species generation in lung
endothelium
JOURNAL J. Biol. Chem. 287 (12), 9360-9375 (2012)
PUBMED 22219181
REMARK GeneRIF: MLCK is essential for the translocation and association of
cortactin and p47phox.
REFERENCE 2 (bases 1 to 7645)
AUTHORS Han,Y.J., Ma,S.F., Wade,M.S., Flores,C. and Garcia,J.G.
TITLE An intronic MYLK variant associated with inflammatory lung disease
regulates promoter activity of the smooth muscle myosin light chain
kinase isoform
JOURNAL J. Mol. Med. 90 (3), 299-308 (2012)
PUBMED 22015949
REMARK GeneRIF: MYLK SNPs downregulate smooth muscle MLCK promoter
activity due to interruption of a FOXN1 binding site. These data
provide new insights into the contribution of MYLK SNPs to
inflammatory disease susceptibility.
REFERENCE 3 (bases 1 to 7645)
AUTHORS Lapointe,T.K. and Buret,A.G.
TITLE Interleukin-18 facilitates neutrophil transmigration via myosin
light chain kinase-dependent disruption of occludin, without
altering epithelial permeability
JOURNAL Am. J. Physiol. Gastrointest. Liver Physiol. 302 (3), G343-G351
(2012)
PUBMED 22135309
REMARK GeneRIF: IL-18 may potentiate inflammation in the context of
inflammatory bowel disease by facilitating neutrophil
transepithelial migration via MLCK-dependent disruption of tight
junctional occludin.
REFERENCE 4 (bases 1 to 7645)
AUTHORS Chen,L., Su,L., Li,J., Zheng,Y., Yu,B., Yu,Y., Yan,M., Gu,Q.,
Zhu,Z. and Liu,B.
TITLE Hypermethylated FAM5C and MYLK in serum as diagnosis and
pre-warning markers for gastric cancer
JOURNAL Dis. Markers 32 (3), 195-202 (2012)
PUBMED 22377736
REMARK GeneRIF: Hypermethylated FAM5C and MYLK in serum are strongly
associated with the development of gastric cancer and can be used
as potential biomarkers for diagnosis and pre-warning.
REFERENCE 5 (bases 1 to 7645)
AUTHORS Stepanova,O.V., Chadin,A.V., Masyutin,A.G., Kulikova,T.G.,
Poltavceva,R.A., Masenko,V.P. and Sukhikh,G.T.
TITLE Myosin-activating protein kinases are possible regulators of
nonmuscle myosin in developing human heart
JOURNAL Bull. Exp. Biol. Med. 152 (2), 198-201 (2011)
PUBMED 22808459
REMARK GeneRIF: The approximate time period of changes in the ratios of
MLCK-108 and MLCK-210 was revealed (between 8-9 and 13 weeks), that
can be associated with functional changes in the developing
myocardium.
REFERENCE 6 (bases 1 to 7645)
AUTHORS Torok,K. and Trentham,D.R.
TITLE Mechanism of 2-chloro-(epsilon-amino-Lys75)-[6-[4-(N,N-
diethylamino)phenyl]-1,3,5-triazin-4-yl]calmodulin interactions
with smooth muscle myosin light chain kinase and derived peptides
JOURNAL Biochemistry 33 (43), 12807-12820 (1994)
PUBMED 7947686
REFERENCE 7 (bases 1 to 7645)
AUTHORS Ikebe,M. and Reardon,S.
TITLE Phosphorylation of smooth myosin light chain kinase by smooth
muscle Ca2+/calmodulin-dependent multifunctional protein kinase
JOURNAL J. Biol. Chem. 265 (16), 8975-8978 (1990)
PUBMED 2160950
REFERENCE 8 (bases 1 to 7645)
AUTHORS Ikebe,M., Hartshorne,D.J. and Elzinga,M.
TITLE Identification, phosphorylation, and dephosphorylation of a second
site for myosin light chain kinase on the 20,000-dalton light chain
of smooth muscle myosin
JOURNAL J. Biol. Chem. 261 (1), 36-39 (1986)
PUBMED 3079756
REFERENCE 9 (bases 1 to 7645)
AUTHORS Nishikawa,M., Shirakawa,S. and Adelstein,R.S.
TITLE Phosphorylation of smooth muscle myosin light chain kinase by
protein kinase C. Comparative study of the phosphorylated sites
JOURNAL J. Biol. Chem. 260 (15), 8978-8983 (1985)
PUBMED 3160694
REFERENCE 10 (bases 1 to 7645)
AUTHORS Nishikawa,M., de Lanerolle,P., Lincoln,T.M. and Adelstein,R.S.
TITLE Phosphorylation of mammalian myosin light chain kinases by the
catalytic subunit of cyclic AMP-dependent protein kinase and by
cyclic GMP-dependent protein kinase
JOURNAL J. Biol. Chem. 259 (13), 8429-8436 (1984)
PUBMED 6547441
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from BC064695.1, AC117381.5,
U48959.2, AC020634.16, AY339601.1, AC023165.20 and BC064420.1.
On Oct 10, 2006 this sequence version replaced gi:47132562.
Summary: This gene, a muscle member of the immunoglobulin gene
superfamily, encodes myosin light chain kinase which is a
calcium/calmodulin dependent enzyme. This kinase phosphorylates
myosin regulatory light chains to facilitate myosin interaction
with actin filaments to produce contractile activity. This gene
encodes both smooth muscle and nonmuscle isoforms. In addition,
using a separate promoter in an intron in the 3' region, it encodes
telokin, a small protein identical in sequence to the C-terminus of
myosin light chain kinase, that is independently expressed in
smooth muscle and functions to stabilize unphosphorylated myosin
filaments. A pseudogene is located on the p arm of chromosome 3.
Four transcript variants that produce four isoforms of the
calcium/calmodulin dependent enzyme have been identified as well as
two transcripts that produce two isoforms of telokin. Additional
variants have been identified but lack full length transcripts.
[provided by RefSeq, Jul 2008].
Transcript Variant: This variant (2) does not utilize exon 11,
compared to variant 1, resulting in a shorter protein (isoform 2),
compared to isoform 1.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
CDS exon combination :: AF069601.2, AY424269.1 [ECO:0000331]
RNAseq introns :: mixed/partial sample support ERS025081,
ERS025082 [ECO:0000350]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-129 BC064695.1 2-130
130-130 AC117381.5 45518-45518 c
131-447 BC064695.1 132-448
448-720 U48959.2 285-557
721-721 AC020634.16 94026-94026
722-1591 U48959.2 559-1428
1592-5820 AY339601.1 1517-5745
5821-7611 AC023165.20 39793-41583
7612-7645 BC064420.1 2491-2524
FEATURES Location/Qualifiers
source 1..7645
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="3"
/map="3q21"
gene 1..7645
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/note="myosin light chain kinase"
/db_xref="GeneID:4638"
/db_xref="HGNC:7590"
/db_xref="MIM:600922"
exon 1..97
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/inference="alignment:Splign:1.39.8"
exon 98..156
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/inference="alignment:Splign:1.39.8"
misc_feature 139..141
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/note="upstream in-frame stop codon"
exon 157..279
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/inference="alignment:Splign:1.39.8"
exon 280..447
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/inference="alignment:Splign:1.39.8"
CDS 283..5820
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/EC_number="2.7.11.18"
/note="isoform 2 is encoded by transcript variant 2;
smooth muscle myosin light chain kinase; myosin, light
polypeptide kinase; telokin; kinase-related protein"
/codon_start=1
/product="myosin light chain kinase, smooth muscle isoform
2"
/protein_id="NP_444254.3"
/db_xref="GI:116008188"
/db_xref="CCDS:CCDS43141.1"
/db_xref="GeneID:4638"
/db_xref="HGNC:7590"
/db_xref="MIM:600922"
/translation="
MGDVKLVASSHISKTSLSVDPSRVDSMPLTEAPAFILPPRNLCIKEGATAKFEGRVRGYPEPQVTWHRNGQPITSGGRFLLDCGIRGTFSLVIHAVHEEDRGKYTCEATNGSGARQVTVELTVEGSFAKQLGQPVVSKTLGDRFSAPAVETRPSIWGECPPKFATKLGRVVVKEGQMGRFSCKITGRPQPQVTWLKGNVPLQPSARVSVSEKNGMQVLEIHGVNQDDVGVYTCLVVNGSGKASMSAELSIQGLDSANRSFVRETKATNSDVRKEVTNVISKESKLDSLEAAAKSKNCSSPQRGGSPPWAANSQPQPPRESKLESCKDSPRTAPQTPVLQKTSSSITLQAARVQPEPRAPGLGVLSPSGEERKRPAPPRPATFPTRQPGLGSQDVVSKAANRRIPMEGQRDSAFPKFESKPQSQEVKENQTVKFRCEGLAVMEVAPSFSSVLKDCAVIEGQDFVLQCSVRGTPVPRITWLLNGQPIQYARSTCEAGVAELHIQDALPEDHGTYTCLAENALGQVSCSAWVTVHEKKSSRKSEYLLPVAPSKPTAPIFLQGLSDLKVMDGSQVTMTVQVSGNPPPEVIWLHNGNEIQESEDFHFEQRGTQHSLCIQEVFPEDTGTYTCEAWNSAGEVRTQAVLTVQEPHDGTQPWFISKPRSVTASLGQSVLISCAIAGDPFPTVHWLRDGKALCKDTGHFEVLQNEDVFTLVLKKVQPWHAGQYEILLKNRVGECSCQVSLMLQNSSARALPRGREPASCEDLCGGGVGADGGGSDRYGSLRPGWPARGQGWLEEEDGEDVRGVLKRRVETRQHTEEAIRQQEVEQLDFRDLLGKKVSTKTLSEDDLKEIPAEQMDFRANLQRQVKPKTVSEEERKVHSPQQVDFRSVLAKKGTSKTPVPEKVPPPKPATPDFRSVLGGKKKLPAENGSSSAETLNAKAVESSKPLSNAQPSGPLKPVGNAKPAETLKPMGNAKPAETLKPMGNAKPDENLKSASKEELKKDVKNDVNCKRGHAGTTDNEKRSESQGTAPAFKQKLQDVHVAEGKKLLLQCQVSSDPPATIIWTLNGKTLKTTKFIILSQEGSLCSVSIEKALPEDRGLYKCVAKNDAGQAECSCQVTVDDAPASENTKAPEMKSRRPKSSLPPVLGTESDATVKKKPAPKTPPKAAMPPQIIQFPEDQKVRAGESVELFGKVTGTQPITCTWMKFRKQIQESEHMKVENSENGSKLTILAARQEHCGCYTLLVENKLGSRQAQVNLTVVDKPDPPAGTPCASDIRSSSLTLSWYGSSYDGGSAVQSYSIEIWDSANKTWKELATCRSTSFNVQDLLPDHEYKFRVRAINVYGTSEPSQESELTTVGEKPEEPKDEVEVSDDDEKEPEVDYRTVTINTEQKVSDFYDIEERLGSGKFGQVFRLVEKKTRKVWAGKFFKAYSAKEKENIRQEISIMNCLHHPKLVQCVDAFEEKANIVMVLEIVSGGELFERIIDEDFELTERECIKYMRQISEGVEYIHKQGIVHLDLKPENIMCVNKTGTRIKLIDFGLARRLENAGSLKVLFGTPEFVAPEVINYEPIGYATDMWSIGVICYILVSGLSPFMGDNDNETLANVTSATWDFDDEAFDEISDDAKDFISNLLKKDMKNRLDCTQCLQHPWLMKDTKNMEAKKLSKDRMKKYMARRKWQKTGNAVRAIGRLSSMAMISGLSGRKSSTGSPTSPLNAEKLESEEDVSQAFLEAVAEEKPHVKPYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVVWFKDDQSIRESRHFQIDYDEDGNCSLIISDVCGDDDAKYTCKAVNSLGEATCTAELIVETMEEGEGEGEEEEE
"
misc_feature 379..651
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/note="Immunoglobulin I-set domain; Region: I-set;
pfam07679"
/db_xref="CDD:191810"
misc_feature 445..642
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/note="Immunoglobulin domain; Region: Ig; cd00096"
/db_xref="CDD:143165"
misc_feature 763..1032
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/note="Immunoglobulin I-set domain; Region: I-set;
pfam07679"
/db_xref="CDD:191810"
misc_feature 817..1023
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/note="Immunoglobulin domain; Region: Ig; cd00096"
/db_xref="CDD:143165"
misc_feature 1615..1875
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/note="Immunoglobulin I-set domain; Region: I-set;
pfam07679"
/db_xref="CDD:191810"
misc_feature 1669..1866
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/note="Immunoglobulin domain; Region: Ig; cd00096"
/db_xref="CDD:143165"
misc_feature 1942..2211
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/note="Immunoglobulin I-set domain; Region: I-set;
pfam07679"
/db_xref="CDD:191810"
misc_feature 1993..2202
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/note="Immunoglobulin domain; Region: Ig; cd00096"
/db_xref="CDD:143165"
misc_feature 2236..2502
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/note="Immunoglobulin I-set domain; Region: I-set;
pfam07679"
/db_xref="CDD:191810"
misc_feature 2254..2502
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/note="Immunoglobulin like; Region: IG_like; smart00410"
/db_xref="CDD:197708"
misc_feature 3367..3636
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/note="Immunoglobulin I-set domain; Region: I-set;
pfam07679"
/db_xref="CDD:191810"
misc_feature 3418..3621
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/note="Immunoglobulin domain; Region: Ig; cd00096"
/db_xref="CDD:143165"
misc_feature 3790..4080
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/note="Eighth immunoglobulin (Ig)-like domain of human
myosin light-chain kinase (MLCK); Region: Ig8_MLCK;
cd05762"
/db_xref="CDD:143239"
misc_feature 3790..4056
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/note="Immunoglobulin I-set domain; Region: I-set;
pfam07679"
/db_xref="CDD:191810"
misc_feature <4147..4344
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/note="Fibronectin type 3 domain; One of three types of
internal repeats found in the plasma protein fibronectin.
Its tenth fibronectin type III repeat contains an RGD cell
recognition sequence in a flexible loop between 2 strands.
Approximately 2% of all...; Region: FN3; cd00063"
/db_xref="CDD:28945"
misc_feature order(4261..4263,4306..4308)
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/note="Interdomain contacts; other site"
/db_xref="CDD:28945"
misc_feature order(4309..4314,4318..4323)
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/note="Cytokine receptor motif; other site"
/db_xref="CDD:28945"
misc_feature 4465..5232
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/note="Serine/Threonine protein kinases, catalytic domain;
Region: S_TKc; smart00220"
/db_xref="CDD:197582"
misc_feature 4483..5226
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/note="Catalytic domain of Protein Kinases; Region: PKc;
cd00180"
/db_xref="CDD:173623"
misc_feature order(4483..4497,4507..4509,4546..4548,4552..4554,
4639..4641,4687..4698,4708..4710,4714..4716,4828..4830,
4834..4836,4840..4845,4849..4851,4888..4890,4897..4899,
4942..4953)
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/note="active site"
/db_xref="CDD:173623"
misc_feature order(4483..4497,4507..4509,4546..4548,4552..4554,
4639..4641,4687..4698,4708..4710,4828..4830,4834..4836,
4840..4845,4849..4851,4888..4890)
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/note="ATP binding site [chemical binding]; other site"
/db_xref="CDD:173623"
misc_feature order(4495..4497,4708..4710,4714..4716,4828..4830,
4834..4836,4840..4842,4897..4899,4942..4953)
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/note="substrate binding site [chemical binding]; other
site"
/db_xref="CDD:173623"
misc_feature order(4885..4905,4942..4953)
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/note="activation loop (A-loop); other site"
/db_xref="CDD:173623"
misc_feature 5500..5772
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/note="Immunoglobulin I-set domain; Region: I-set;
pfam07679"
/db_xref="CDD:191810"
misc_feature 5551..5763
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/note="Immunoglobulin domain; Region: Ig; cd00096"
/db_xref="CDD:143165"
exon 448..655
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/inference="alignment:Splign:1.39.8"
exon 656..704
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/inference="alignment:Splign:1.39.8"
exon 705..870
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/inference="alignment:Splign:1.39.8"
exon 871..1036
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/inference="alignment:Splign:1.39.8"
exon 1037..1055
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/inference="alignment:Splign:1.39.8"
exon 1056..1591
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/inference="alignment:Splign:1.39.8"
exon 1592..1726
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/inference="alignment:Splign:1.39.8"
exon 1727..1879
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/inference="alignment:Splign:1.39.8"
exon 1880..2017
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/inference="alignment:Splign:1.39.8"
exon 2018..2215
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/inference="alignment:Splign:1.39.8"
exon 2216..2465
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/inference="alignment:Splign:1.39.8"
exon 2466..2537
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/inference="alignment:Splign:1.39.8"
exon 2538..3523
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/inference="alignment:Splign:1.39.8"
variation 2608
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/replace="c"
/replace="t"
/db_xref="dbSNP:3732485"
variation 2657
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/replace="c"
/replace="t"
/db_xref="dbSNP:3732486"
variation 2704
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/replace="a"
/replace="g"
/db_xref="dbSNP:34542174"
variation 2769
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/replace="a"
/replace="c"
/db_xref="dbSNP:1064963"
variation 2781
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/replace="c"
/replace="g"
/db_xref="dbSNP:1064964"
variation 2817
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/replace="a"
/replace="c"
/db_xref="dbSNP:3732487"
variation 2832
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/replace="a"
/replace="g"
/db_xref="dbSNP:1064965"
variation 2853
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/replace="c"
/replace="t"
/db_xref="dbSNP:1064966"
variation 2872
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/replace="a"
/replace="g"
/db_xref="dbSNP:1064967"
variation 2922
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/replace="a"
/replace="g"
/db_xref="dbSNP:1064968"
variation 2940
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/replace="c"
/replace="t"
/db_xref="dbSNP:1064969"
variation 2946
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/replace="a"
/replace="g"
/db_xref="dbSNP:1064970"
variation 2962
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/replace="c"
/replace="t"
/db_xref="dbSNP:3207817"
variation 3259
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/replace="a"
/replace="g"
/db_xref="dbSNP:11558550"
variation 3477
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/replace="c"
/replace="t"
/db_xref="dbSNP:865358"
exon 3524..3640
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/inference="alignment:Splign:1.39.8"
variation 3633
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/replace="a"
/replace="c"
/replace="t"
/db_xref="dbSNP:40305"
exon 3641..3727
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/inference="alignment:Splign:1.39.8"
exon 3728..3778
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/inference="alignment:Splign:1.39.8"
exon 3779..3906
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/inference="alignment:Splign:1.39.8"
exon 3907..4060
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/inference="alignment:Splign:1.39.8"
variation 3915
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/replace="a"
/replace="c"
/db_xref="dbSNP:3205951"
variation 3927
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/replace="c"
/replace="g"
/db_xref="dbSNP:1142295"
exon 4061..4363
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/inference="alignment:Splign:1.39.8"
variation 4096
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/replace="c"
/replace="t"
/db_xref="dbSNP:41530452"
STS 4187..4307
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/standard_name="SHGC-77269"
/db_xref="UniSTS:53737"
exon 4364..4396
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/inference="alignment:Splign:1.39.8"
variation 4392
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/replace="c"
/replace="t"
/db_xref="dbSNP:1254392"
exon 4397..4490
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/inference="alignment:Splign:1.39.8"
variation 4424
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/replace="a"
/replace="g"
/db_xref="dbSNP:41366751"
exon 4491..4694
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/inference="alignment:Splign:1.39.8"
exon 4695..4912
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/inference="alignment:Splign:1.39.8"
exon 4913..5036
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/inference="alignment:Splign:1.39.8"
exon 5037..5189
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/inference="alignment:Splign:1.39.8"
exon 5190..5313
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/inference="alignment:Splign:1.39.8"
exon 5314..5443
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/inference="alignment:Splign:1.39.8"
exon 5444..5575
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/inference="alignment:Splign:1.39.8"
variation 5544
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/replace="a"
/replace="g"
/db_xref="dbSNP:1804614"
exon 5576..7629
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/inference="alignment:Splign:1.39.8"
variation 5599
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/replace="c"
/replace="t"
/db_xref="dbSNP:1804613"
STS 5643..5792
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/standard_name="RH77851"
/db_xref="UniSTS:45321"
variation 5765
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/replace="a"
/replace="t"
/db_xref="dbSNP:1065022"
variation 6432
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/replace="a"
/replace="c"
/db_xref="dbSNP:9422"
variation 7173
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/replace="a"
/replace="t"
/db_xref="dbSNP:3190420"
STS 7190..7364
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/standard_name="RH45477"
/db_xref="UniSTS:10789"
STS 7190..7364
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/standard_name="stSG16293"
STS 7237..7370
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/standard_name="A004V23"
/db_xref="UniSTS:57532"
STS 7237..7370
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/standard_name="TIGR-A004V23"
STS 7356..7501
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/standard_name="A006U08"
STS 7356..7501
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/standard_name="A006U08"
/db_xref="UniSTS:28559"
polyA_signal 7370..7375
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
polyA_site 7389
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
STS 7394..7562
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/standard_name="RH36624"
/db_xref="UniSTS:67934"
STS 7394..7562
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
/standard_name="stSG15806"
polyA_signal 7595..7600
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
polyA_site 7615
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
polyA_site 7629
/gene="MYLK"
/gene_synonym="AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210;
MSTP083; MYLK1; smMLCK"
ORIGIN
ggcgctgagcgagctcggagcccgcgctgtgcgcctgcggccggggcgccccgccgagcgccggtgccccggctcccgggccgccttcgccgcgcgggaaggattcttcaaaattaacagaaaccaattcgggccagctgaagagaaaaaataaaggtggctcccggctgcctctgctgcagttcagagcaacttcaggagcttcccagccgagagcttcaggacgcctttcctgtcccactggcccagttgccacaacaaacaacagagaagacggtgaccatgggggatgtgaagctggttgcctcgtcacacatttccaaaacctccctcagtgtggatccctcaagagttgactccatgcccctgacagaggcccctgctttcattttgccccctcggaacctctgcatcaaagaaggagccaccgccaagttcgaagggcgggtccggggttacccagagccccaggtgacatggcacagaaacgggcaacccatcaccagcgggggccgcttcctgctggattgcggcatccgggggactttcagccttgtgattcatgctgtccatgaggaggacaggggaaagtatacctgtgaagccaccaatggcagtggtgctcgccaggtgacagtggagttgacagtagaaggaagttttgcgaagcagcttggtcagcctgttgtttccaaaaccttaggggatagattttcagctccagcagtggagacccgtcctagcatctggggggagtgcccaccaaagtttgctaccaagctgggccgagttgtggtcaaagaaggacagatgggacgattctcctgcaagatcactggccggccccaaccgcaggtcacctggctcaagggaaatgttccactgcagccgagtgcccgtgtgtctgtgtctgagaagaacggcatgcaggttctggaaatccatggagtcaaccaagatgacgtgggagtgtacacgtgcctggtggtgaacgggtcggggaaggcctcgatgtcagctgaactttccatccaaggtttggacagtgccaataggtcatttgtgagagaaacaaaagccaccaattcagatgtcaggaaagaggtgaccaatgtaatctcaaaggagtcgaagctggacagtctggaggctgcagccaaaagcaagaactgctccagcccccagagaggtggctccccaccctgggctgcaaacagccagcctcagcccccaagggagtccaagctggagtcatgcaaggactcgcccagaacggccccgcagaccccggtccttcagaagacttccagctccatcaccctgcaggccgcaagagttcagccggaaccaagagcaccaggcctgggggtcctatcaccttctggagaagagaggaagaggccagctcctccccgtccagccaccttccccaccaggcagcctggcctggggagccaagatgttgtgagcaaggctgctaacaggagaatccccatggagggccagagggattcagcattccccaaatttgagagcaagccccaaagccaggaggtcaaggaaaatcaaactgtcaagttcagatgtgaagggcttgccgtgatggaggtggccccctccttctccagtgtcctgaaggactgcgctgttattgagggccaggattttgtgctgcagtgctccgtacgggggaccccagtgccccggatcacttggctgctgaatgggcagcccatccagtacgctcgctccacctgcgaggccggcgtggctgagctccacatccaggatgccctgccggaggaccatggcacctacacctgcctagctgagaatgccttggggcaggtgtcctgcagcgcctgggtcaccgtccatgaaaagaagagtagcaggaagagtgagtaccttctgcctgtggctcccagcaagcccactgcacccatcttcctgcagggcctctctgatctcaaagtcatggatggaagccaggtcactatgactgtccaagtgtcagggaatccaccccctgaagtcatctggctgcacaatgggaatgagatccaagagtcagaggacttccactttgaacagagaggaactcagcacagcctttgtatccaggaagtgttcccggaggacacgggcacgtacacctgcgaggcctggaacagcgctggagaggtccgcacccaggccgtgctcacggtacaagagcctcacgatggcacccagccctggttcatcagtaagcctcgctcagtgacagcctccctgggccagagtgtcctcatctcctgcgccatagctggtgacccctttcctaccgtgcactggctcagagatggcaaagccctctgcaaagacactggccacttcgaggtgcttcagaatgaggacgtgttcaccctggttctaaagaaggtgcagccctggcatgccggccagtatgagatcctgctcaagaaccgggttggcgaatgcagttgccaggtgtcactgatgctacagaacagctctgccagagcccttccacgggggagggagcctgccagctgcgaggacctctgtggtggaggagttggtgctgatggtggtggtagtgaccgctatgggtccctgaggcctggctggccagcaagagggcagggttggctagaggaggaagacggcgaggacgtgcgaggggtgctgaagaggcgcgtggagacgaggcagcacactgaggaggcgatccgccagcaggaggtggagcagctggacttccgagacctcctggggaagaaggtgagtacaaagaccctatcggaagacgacctgaaggagatcccagccgagcagatggatttccgtgccaacctgcagcggcaagtgaagccaaagactgtgtctgaggaagagaggaaggtgcacagcccccagcaggtcgattttcgctctgtcctggccaagaaggggacttccaagacccccgtgcctgagaaggtgccaccgccaaaacctgccaccccggattttcgctcagtgctgggtggcaagaagaaattaccagcagagaatggcagcagcagtgccgagaccctgaatgccaaggcagtggagagttccaagcccctgagcaatgcacagccttcagggcccttgaaacccgtgggcaacgccaagcctgctgagaccctgaagccaatgggcaacgccaagcctgccgagaccctgaagcccatgggcaatgccaagcctgatgagaacctgaaatccgctagcaaagaagaactcaagaaagacgttaagaatgatgtgaactgcaagagaggccatgcagggaccacagataatgaaaagagatcagagagccaggggacagccccagccttcaagcagaagctgcaagatgttcatgtggcagagggcaagaagctgctgctccagtgccaggtgtcttctgaccccccagccaccatcatctggacgctgaacggaaagaccctcaagaccaccaagttcatcatcctctcccaggaaggctcactctgctccgtctccatcgagaaggcactgcctgaggacagaggcttatacaagtgtgtagccaagaatgacgctggccaggcggagtgctcctgccaagtcaccgtggatgatgctccagccagtgagaacaccaaggccccagagatgaaatcccggaggcccaagagctctcttcctcccgtgctaggaactgagagtgatgcgactgtgaaaaagaaacctgcccccaagacacctccgaaggcagcaatgccccctcagatcatccagttccctgaggaccagaaggtacgcgcaggagagtcagtggagctgtttggcaaagtgacaggcactcagcccatcacctgtacctggatgaagttccgaaagcagatccaggaaagcgagcacatgaaggtggagaacagcgagaatggcagcaagctcaccatcctggccgcgcgccaggagcactgcggctgctacacactgctggtggagaacaagctgggcagcaggcaggcccaggtcaacctcactgtcgtggataagccagaccccccagctggcacaccttgtgcctctgacattcggagctcctcactgaccctgtcctggtatggctcctcatatgatgggggcagtgctgtacagtcctacagcatcgagatctgggactcagccaacaagacgtggaaggaactagccacatgccgcagcacctctttcaacgtccaggacctgctgcctgaccacgaatataagttccgtgtacgtgcaatcaacgtgtatggaaccagtgagccaagccaggagtctgaactcacaacggtaggagagaaacctgaagagccgaaggatgaagtggaggtgtcagatgatgatgagaaggagcccgaggttgattaccggacagtgacaatcaatactgaacaaaaagtatctgacttctacgacattgaggagagattaggatctgggaaatttggacaggtctttcgacttgtagaaaagaaaactcgaaaagtctgggcagggaagttcttcaaggcatattcagcaaaagagaaagagaatatccggcaggagattagcatcatgaactgcctccaccaccctaagctggtccagtgtgtggatgcctttgaagaaaaggccaacatcgtcatggtcctggagatcgtgtcaggaggggagctgtttgagcgcatcattgacgaggactttgagctgacggagcgtgagtgcatcaagtacatgcggcagatctcggagggagtggagtacatccacaagcagggcatcgtgcacctggacctcaagccggagaacatcatgtgtgtcaacaagacgggcaccaggatcaagctcatcgactttggtctggccaggaggctggagaatgcggggtctctgaaggtcctctttggcaccccagaatttgtggctcctgaagtgatcaactatgagcccatcggctacgccacagacatgtggagcatcggggtcatctgctacatcctagtcagtggcctttcccccttcatgggagacaacgataacgaaaccttggccaacgttacctcagccacctgggacttcgacgacgaggcattcgatgagatctccgacgatgccaaggatttcatcagcaatctgctgaagaaagatatgaaaaaccgcctggactgcacgcagtgccttcagcatccatggctaatgaaagataccaagaacatggaggccaagaaactctccaaggaccggatgaagaagtacatggcaagaaggaaatggcagaaaacgggcaatgctgtgagagccattggaagactgtcctctatggcaatgatctcagggctcagtggcaggaaatcctcaacagggtcaccaaccagcccgctcaatgcagaaaaactagaatctgaagaagatgtgtcccaagctttccttgaggctgttgctgaggaaaagcctcatgtaaaaccctatttctctaagaccattcgcgatttagaagttgtggagggaagtgctgctagatttgactgcaagattgaaggatacccagaccccgaggttgtctggttcaaagatgaccagtcaatcagggagtcccgccacttccagatagactacgatgaggacgggaactgctctttaattattagtgatgtttgcggggatgacgatgccaagtacacctgcaaggctgtcaacagtcttggagaagccacctgcacagcagagctcattgtggaaacgatggaggaaggtgaaggggaaggggaagaggaagaagagtgaaacaaagccagagaaaagcagtttctaagtcatattaaaaggactatttctctaaaactcaaaaaaaaaaaaaaaactcaagatagtaaaagcacctagtgtgatagattatcggttaggtcatttgtgggttgattcttcagaaacagcagttgatacctagcagcgttattgatgggcattaatctatgttagttggcaccttaagatactagtgcagctagatttcatttagggaaatcaccagtaacttgactgaccaattgattttagagagaaagtaaccaaaccaaatatttatctgggcaaagtcataaattctccacttgaatgcgctcatgaaaaataaggccaaaacaagagttctgggccacagctcagcccagagggttcctggggatgggaggcctctctctccccaccccctgactctagagaactgggttttctcccagtactccagcaattcatttctgaaagcagttgagccactttattccaaagtacactgcagatgttcaaactctccatttctctttccccttccacctgccagttttgctgactctcaacttgtcatgagtgtaagcattaaggacattatgcttcttcgattctgaagacaggtccctgctcatggatgactctggcttccttaggaaaatatttttcttccaaaatcagtaggaaatctaaacttatcccctctttgcagatgtctagcagcttcagacatttggttaagaacccatgggaaaaaaaaaatccttgctaatgtggtttcctttgtaaaccaggattcttatttgtgctgttatagaatatcagctctgaacgtgtggtaaagatttttgtgtttgaatataggagaaatcagtttgctgaaaagttagtcttaattatctattggccacgatgaaacagatttcaactgataaagagctggagaactccatgtactttggaatctcctccaagatagccagagtttaatacatcttcattctcaacactctccaaagaacttgacctaccttatgggttccatatttttcttcttaaatgtgcatcaatcatgccttgcccccaacctttaaatatattcttagacctggtaaatgcactcagacttgcgtctttaggaatttttaactttctttcactacattggcacttaaattttttctttataaagctttttgaaggtcataaacaaagaccataattgatgatagacctaatacatttcctctgtgtgtgtgtgtaacattccaaatactttttttttcttttccactgtttgtaaggtgcaacaatttaatatttttaagggactttttaagagttccttaagaaccaatttaaaattacttcagtgcaatcctacacagtatcaacattagaattttgatattagtcttatgttatcttccattctatttttatctgctttttgctgctagtttcaaactgccagtatttttccttttgcttttaaaatagttacaatatttttcatgatagccacagtattgccacagtttattataataaagggtttttatttgatttagcgcattcaaagcttttttctatcacttttgtgttcagaatataacctttgtgtgcgtgtatgttgtgtgtgtgcatgtgtggcgtatatgtgtgttacaggttaatgccttcttggaattgtgttaatgttctcttggtttattatgccatcagaatggtaaatgagaacactacaactgtagtcagctcacaatttttaaataaaggataccacagtgcatgctgtttgttcaaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:4638 -> Molecular function: GO:0003779 [actin binding] evidence: IEA
GeneID:4638 -> Molecular function: GO:0004687 [myosin light chain kinase activity] evidence: IDA
GeneID:4638 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:4638 -> Molecular function: GO:0005516 [calmodulin binding] evidence: IEA
GeneID:4638 -> Molecular function: GO:0005524 [ATP binding] evidence: IEA
GeneID:4638 -> Molecular function: GO:0046872 [metal ion binding] evidence: IEA
GeneID:4638 -> Biological process: GO:0006468 [protein phosphorylation] evidence: TAS
GeneID:4638 -> Biological process: GO:0006936 [muscle contraction] evidence: TAS
GeneID:4638 -> Biological process: GO:0006939 [smooth muscle contraction] evidence: ISS
GeneID:4638 -> Biological process: GO:0014820 [tonic smooth muscle contraction] evidence: ISS
GeneID:4638 -> Biological process: GO:0030335 [positive regulation of cell migration] evidence: IDA
GeneID:4638 -> Biological process: GO:0032060 [bleb assembly] evidence: IMP
GeneID:4638 -> Biological process: GO:0051928 [positive regulation of calcium ion transport] evidence: IDA
GeneID:4638 -> Biological process: GO:0060414 [aorta smooth muscle tissue morphogenesis] evidence: IMP
GeneID:4638 -> Biological process: GO:0071476 [cellular hypotonic response] evidence: IDA
GeneID:4638 -> Biological process: GO:0090303 [positive regulation of wound healing] evidence: IDA
GeneID:4638 -> Cellular component: GO:0001725 [stress fiber] evidence: IDA
GeneID:4638 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA
GeneID:4638 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
GeneID:4638 -> Cellular component: GO:0005886 [plasma membrane] evidence: IDA
GeneID:4638 -> Cellular component: GO:0030027 [lamellipodium] evidence: IDA
GeneID:4638 -> Cellular component: GO:0032154 [cleavage furrow] evidence: IDA
ANNOTATIONS from NCBI Entrez Gene (20130726):
NP_444254 -> EC 2.7.11.18
by
@meso_cacase at
DBCLS
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