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2024-03-29 07:34:57, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_033176               1619 bp    mRNA    linear   PRI 15-MAR-2013
DEFINITION  Homo sapiens NK2 homeobox 4 (NKX2-4), mRNA.
ACCESSION   NM_033176 XM_927653 XM_940179
VERSION     NM_033176.1  GI:157426822
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1619)
  AUTHORS   Deloukas,P., Matthews,L.H., Ashurst,J., Burton,J., Gilbert,J.G.,
            Jones,M., Stavrides,G., Almeida,J.P., Babbage,A.K., Bagguley,C.L.,
            Bailey,J., Barlow,K.F., Bates,K.N., Beard,L.M., Beare,D.M.,
            Beasley,O.P., Bird,C.P., Blakey,S.E., Bridgeman,A.M., Brown,A.J.,
            Buck,D., Burrill,W., Butler,A.P., Carder,C., Carter,N.P.,
            Chapman,J.C., Clamp,M., Clark,G., Clark,L.N., Clark,S.Y.,
            Clee,C.M., Clegg,S., Cobley,V.E., Collier,R.E., Connor,R.,
            Corby,N.R., Coulson,A., Coville,G.J., Deadman,R., Dhami,P.,
            Dunn,M., Ellington,A.G., Frankland,J.A., Fraser,A., French,L.,
            Garner,P., Grafham,D.V., Griffiths,C., Griffiths,M.N., Gwilliam,R.,
            Hall,R.E., Hammond,S., Harley,J.L., Heath,P.D., Ho,S., Holden,J.L.,
            Howden,P.J., Huckle,E., Hunt,A.R., Hunt,S.E., Jekosch,K.,
            Johnson,C.M., Johnson,D., Kay,M.P., Kimberley,A.M., King,A.,
            Knights,A., Laird,G.K., Lawlor,S., Lehvaslaiho,M.H., Leversha,M.,
            Lloyd,C., Lloyd,D.M., Lovell,J.D., Marsh,V.L., Martin,S.L.,
            McConnachie,L.J., McLay,K., McMurray,A.A., Milne,S., Mistry,D.,
            Moore,M.J., Mullikin,J.C., Nickerson,T., Oliver,K., Parker,A.,
            Patel,R., Pearce,T.A., Peck,A.I., Phillimore,B.J.,
            Prathalingam,S.R., Plumb,R.W., Ramsay,H., Rice,C.M., Ross,M.T.,
            Scott,C.E., Sehra,H.K., Shownkeen,R., Sims,S., Skuce,C.D.,
            Smith,M.L., Soderlund,C., Steward,C.A., Sulston,J.E., Swann,M.,
            Sycamore,N., Taylor,R., Tee,L., Thomas,D.W., Thorpe,A., Tracey,A.,
            Tromans,A.C., Vaudin,M., Wall,M., Wallis,J.M., Whitehead,S.L.,
            Whittaker,P., Willey,D.L., Williams,L., Williams,S.A., Wilming,L.,
            Wray,P.W., Hubbard,T., Durbin,R.M., Bentley,D.R., Beck,S. and
            Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 20
  JOURNAL   Nature 414 (6866), 865-871 (2001)
   PUBMED   11780052
REFERENCE   2  (bases 1 to 1619)
  AUTHORS   Wang,C.C., Brodnicki,T., Copeland,N.G., Jenkins,N.A. and
            Harvey,R.P.
  TITLE     Conserved linkage of NK-2 homeobox gene pairs Nkx2-2/2-4 and
            Nkx2-1/2-9 in mammals
  JOURNAL   Mamm. Genome 11 (6), 466-468 (2000)
   PUBMED   10818213
REFERENCE   3  (bases 1 to 1619)
  AUTHORS   Price,M., Lazzaro,D., Pohl,T., Mattei,M.G., Ruther,U., Olivo,J.C.,
            Duboule,D. and Di Lauro,R.
  TITLE     Regional expression of the homeobox gene Nkx-2.2 in the developing
            mammalian forebrain
  JOURNAL   Neuron 8 (2), 241-255 (1992)
   PUBMED   1346742
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL158013.25.
            On or before Sep 23, 2007 this sequence version replaced
            gi:113428840, gi:113428988.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-452               AL158013.25        43546-43997         c
            453-1619            AL158013.25        41955-43121         c
FEATURES             Location/Qualifiers
     source          1..1619
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20p11.22"
     gene            1..1619
                     /gene="NKX2-4"
                     /gene_synonym="NKX2.4; NKX2D"
                     /note="NK2 homeobox 4"
                     /db_xref="GeneID:644524"
                     /db_xref="HGNC:7837"
                     /db_xref="MIM:607808"
     exon            1..452
                     /gene="NKX2-4"
                     /gene_synonym="NKX2.4; NKX2D"
                     /inference="alignment:Splign:1.39.8"
     variation       complement(5)
                     /gene="NKX2-4"
                     /gene_synonym="NKX2.4; NKX2D"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:200359338"
     CDS             11..1075
                     /gene="NKX2-4"
                     /gene_synonym="NKX2.4; NKX2D"
                     /note="NK2 transcription factor homolog D; NK2
                     transcription factor related, locus 4"
                     /codon_start=1
                     /product="homeobox protein Nkx-2.4"
                     /protein_id="NP_149416.1"
                     /db_xref="GI:157426823"
                     /db_xref="CCDS:CCDS42855.1"
                     /db_xref="GeneID:644524"
                     /db_xref="HGNC:7837"
                     /db_xref="MIM:607808"
                     /translation="
MSLSPKHTTPFSVSDILSPIEETYKKFSGAMDGAPPGLGAPLGAAAAYRAPPPGPSSQAATVAGMQPSHAMAGHNAAAAAAAAAAAAAAAATYHMPPGVSQFPHGAMGSYCNGGLGNMGELPAYTDGMRGGAATGWYGANPDPRYSSISRFMGPSAGVNVAGMGSLTGIADAAKSLGPLHAAAAAAAPRRKRRVLFSQAQVYELERRFKQQKYLSAPEREHLASMIHLTPTQVKIWFQNHRYKMKRQAKDKAAQQLQQEGGLGPPPPPPPSPRRVAVPVLVKDGKPCQNGASTPTPGQAGPQPPAPTPAPELEELSPSPPALHGPGGGLAALDAAAGEYSGGVLGANLLYGRTW
"
     misc_feature    578..742
                     /gene="NKX2-4"
                     /gene_synonym="NKX2.4; NKX2D"
                     /note="Homeodomain;  DNA binding domains involved in the
                     transcriptional regulation of key eukaryotic developmental
                     processes; may bind to DNA as monomers or as homo- and/or
                     heterodimers, in a sequence-specific manner; Region:
                     homeodomain; cd00086"
                     /db_xref="CDD:28970"
     misc_feature    order(578..592,596..598,647..649,665..667,704..706,
                     710..715,722..727,731..739)
                     /gene="NKX2-4"
                     /gene_synonym="NKX2.4; NKX2D"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:28970"
     misc_feature    order(584..586,593..595,713..715,722..727,734..736)
                     /gene="NKX2-4"
                     /gene_synonym="NKX2.4; NKX2D"
                     /note="specific DNA base contacts [nucleotide binding];
                     other site"
                     /db_xref="CDD:28970"
     variation       complement(31)
                     /gene="NKX2-4"
                     /gene_synonym="NKX2.4; NKX2D"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:368288200"
     variation       complement(56)
                     /gene="NKX2-4"
                     /gene_synonym="NKX2.4; NKX2D"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:375499093"
     variation       complement(226)
                     /gene="NKX2-4"
                     /gene_synonym="NKX2.4; NKX2D"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:76085962"
     variation       complement(336)
                     /gene="NKX2-4"
                     /gene_synonym="NKX2.4; NKX2D"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:201962740"
     exon            453..1619
                     /gene="NKX2-4"
                     /gene_synonym="NKX2.4; NKX2D"
                     /inference="alignment:Splign:1.39.8"
     variation       complement(541)
                     /gene="NKX2-4"
                     /gene_synonym="NKX2.4; NKX2D"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:199747643"
     variation       complement(573)
                     /gene="NKX2-4"
                     /gene_synonym="NKX2.4; NKX2D"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:370549869"
     variation       complement(643)
                     /gene="NKX2-4"
                     /gene_synonym="NKX2.4; NKX2D"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:371741137"
     variation       complement(654)
                     /gene="NKX2-4"
                     /gene_synonym="NKX2.4; NKX2D"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:367598502"
     variation       complement(667)
                     /gene="NKX2-4"
                     /gene_synonym="NKX2.4; NKX2D"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:375642949"
     variation       complement(687)
                     /gene="NKX2-4"
                     /gene_synonym="NKX2.4; NKX2D"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:371025178"
     variation       complement(709)
                     /gene="NKX2-4"
                     /gene_synonym="NKX2.4; NKX2D"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:181422340"
     variation       complement(730)
                     /gene="NKX2-4"
                     /gene_synonym="NKX2.4; NKX2D"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:199964105"
     variation       complement(733)
                     /gene="NKX2-4"
                     /gene_synonym="NKX2.4; NKX2D"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:376119111"
     variation       complement(763)
                     /gene="NKX2-4"
                     /gene_synonym="NKX2.4; NKX2D"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:6035869"
     variation       complement(1016)
                     /gene="NKX2-4"
                     /gene_synonym="NKX2.4; NKX2D"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:112136447"
     variation       complement(1087)
                     /gene="NKX2-4"
                     /gene_synonym="NKX2.4; NKX2D"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:373054893"
     variation       complement(1111)
                     /gene="NKX2-4"
                     /gene_synonym="NKX2.4; NKX2D"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:369376945"
     variation       complement(1113)
                     /gene="NKX2-4"
                     /gene_synonym="NKX2.4; NKX2D"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:376075030"
     variation       complement(1126)
                     /gene="NKX2-4"
                     /gene_synonym="NKX2.4; NKX2D"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:372702328"
     variation       complement(1349)
                     /gene="NKX2-4"
                     /gene_synonym="NKX2.4; NKX2D"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:369880500"
     variation       complement(1426)
                     /gene="NKX2-4"
                     /gene_synonym="NKX2.4; NKX2D"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:375954224"
ORIGIN      
ccgccgagccatgtcgttgagcccaaagcacacgacgcccttctccgtgtccgacatcctgagccccatcgaggagacctacaagaagttcagcggcgccatggacggcgcgccacccggcctgggggcgcccctgggggccgcggccgcctaccgcgcgccgccacctgggccctcctcgcaggcggcgaccgtggcgggcatgcagccttctcacgccatggcgggtcacaacgcggcggccgcggcggcggcggcagcagctgcggcggcggcggccgccacctaccacatgccgcccggcgtctcgcagttcccgcacggcgccatgggcagctactgcaacggcggcctgggcaacatgggcgagctgcccgcctacacggacggcatgcggggcggcgcggccaccggctggtacggcgccaacccggacccacgctactcgtcaatctccaggttcatggggccgtcggcgggcgtgaatgtggccggcatggggtcgctgaccggcatcgcggacgccgccaagtcgctgggcccgctgcacgcggcggcggcggcagccgctccgcgaaggaagcgccgcgtgctcttctcgcaggcgcaggtctacgagctggagcggcgcttcaagcagcagaagtacctgtcggcgcccgagcgcgagcacctggccagcatgatccacctgacgcccacgcaggtcaagatctggttccagaaccaccggtacaagatgaaacggcaggccaaggacaaggcggcgcagcagctgcagcaggagggcggcctgggcccgccgccgcctccgccgccgtccccgcgccgcgtggcggtgcctgtgctggtcaaggacggcaagccgtgccagaacggcgccagcacgcccacccccggccaggccggtccgcagccgccggccccgacgccagcacctgagctggaggagctgtcgcccagcccacccgcgctgcacggcccggggggcggcctggcggccctggacgcggccgccggggagtacagcggcggcgtcctgggcgccaacctgctctatggcaggacgtggtgacagcgagggcgccccggggctaggtcctggtgcacccgaagggtctgcaagaaactgctagaacggatgggggaggcatgcgaaaaccgactcgcgcgtgtaaactgcgattcaaaacgaaccggtctcagagaggagcaggctgtgaacctcttgctgggggcgggggacagcgacagcccggaaaccgagtagtgtaacattatgccacgaggctttgaggtggtgattttctcctcctagaagttcttaaatgacgcgaaaaggtggagaagttcacacggcattcttaactacagctctcaaagttggaaactttgttggcgtttgtaactataaaaatcaacccagctttaacaatcagtcctttttgaagtggaatttatcttgggagattaattttcgaagggccccctaagtgcaatttcattaatgtttgattgaaagtaaattgaagtgtagctcaaggtggatcatacacatagcaacattattgcagaggaattattgccatttaggtaatagagcaatggaatcaaaataa
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:644524 -> Molecular function: GO:0003674 [molecular_function] evidence: ND
            GeneID:644524 -> Molecular function: GO:0003700 [sequence-specific DNA binding transcription factor activity] evidence: IEA
            GeneID:644524 -> Molecular function: GO:0043565 [sequence-specific DNA binding] evidence: IEA
            GeneID:644524 -> Biological process: GO:0007275 [multicellular organismal development] evidence: IEA
            GeneID:644524 -> Biological process: GO:0008150 [biological_process] evidence: ND
            GeneID:644524 -> Cellular component: GO:0005575 [cellular_component] evidence: ND
            GeneID:644524 -> Cellular component: GO:0005634 [nucleus] evidence: IEA

by @meso_cacase at DBCLS
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