LOCUS       NM_024852               3667 bp    mRNA    linear   PRI 08-JUL-2013
DEFINITION  Homo sapiens argonaute RISC catalytic component 3 (AGO3),
            transcript variant 1, mRNA.
ACCESSION   NM_024852
VERSION     NM_024852.3  GI:324073530
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3667)
  AUTHORS   Hu,Q., Tanasa,B., Trabucchi,M., Li,W., Zhang,J., Ohgi,K.A.,
            Rose,D.W., Glass,C.K. and Rosenfeld,M.G.
  TITLE     DICER- and AGO3-dependent generation of retinoic acid-induced DR2
            Alu RNAs regulates human stem cell proliferation
  JOURNAL   Nat. Struct. Mol. Biol. 19 (11), 1168-1175 (2012)
   PUBMED   23064648
  REMARK    GeneRIF: DICER- and AGO3-dependent generation of retinoic
            acid-induced DR2 Alu RNAs regulates human stem cell proliferation.
REFERENCE   2  (bases 1 to 3667)
  AUTHORS   Wang,D., Zhang,Z., O'Loughlin,E., Lee,T., Houel,S., O'Carroll,D.,
            Tarakhovsky,A., Ahn,N.G. and Yi,R.
  TITLE     Quantitative functions of Argonaute proteins in mammalian
            development
  JOURNAL   Genes Dev. 26 (7), 693-704 (2012)
   PUBMED   22474261
  REMARK    GeneRIF: Ago3 is able to load microRNAs efficiently in the absence
            of Ago1 and Ago2, despite a significant loss of global microRNA
            expression
REFERENCE   3  (bases 1 to 3667)
  AUTHORS   Omel'ianchuk,N.A., Ponomarenko,P.M. and Ponomarenko,M.P.
  TITLE     [The nucleotide sequence features of the mature microRNA seem to be
            responsible for the affinity to human Ago2 AND Ago3 proteins]
  JOURNAL   Mol. Biol. (Mosk.) 45 (2), 366-375 (2011)
   PUBMED   21634124
  REMARK    GeneRIF: reliable predictions of miRNA affinity to Ago2 AND Ago3
            proteins were made.
REFERENCE   4  (bases 1 to 3667)
  AUTHORS   Potenza,N., Papa,U. and Russo,A.
  TITLE     Differential expression of Dicer and Argonaute genes during the
            differentiation of human neuroblastoma cells
  JOURNAL   Cell Biol. Int. 33 (7), 734-738 (2009)
   PUBMED   19393748
  REMARK    GeneRIF: EIF@C3 protein is expressed in both Schwann and
            neuron-type differentiating cells.
REFERENCE   5  (bases 1 to 3667)
  AUTHORS   Weinmann,L., Hock,J., Ivacevic,T., Ohrt,T., Mutze,J., Schwille,P.,
            Kremmer,E., Benes,V., Urlaub,H. and Meister,G.
  TITLE     Importin 8 is a gene silencing factor that targets argonaute
            proteins to distinct mRNAs
  JOURNAL   Cell 136 (3), 496-507 (2009)
   PUBMED   19167051
REFERENCE   6  (bases 1 to 3667)
  AUTHORS   Wu,L., Fan,J. and Belasco,J.G.
  TITLE     Importance of translation and nonnucleolytic ago proteins for
            on-target RNA interference
  JOURNAL   Curr. Biol. 18 (17), 1327-1332 (2008)
   PUBMED   18771919
  REMARK    GeneRIF: The specificity of RNA interference depends on the
            concentration of Ago1, Ago3, and Ago4 relative to Ago2.
REFERENCE   7  (bases 1 to 3667)
  AUTHORS   Sasaki,T., Shiohama,A., Minoshima,S. and Shimizu,N.
  TITLE     Identification of eight members of the Argonaute family in the
            human genome small star, filled
  JOURNAL   Genomics 82 (3), 323-330 (2003)
   PUBMED   12906857
REFERENCE   8  (bases 1 to 3667)
  AUTHORS   Doi,N., Zenno,S., Ueda,R., Ohki-Hamazaki,H., Ui-Tei,K. and Saigo,K.
  TITLE     Short-interfering-RNA-mediated gene silencing in mammalian cells
            requires Dicer and eIF2C translation initiation factors
  JOURNAL   Curr. Biol. 13 (1), 41-46 (2003)
   PUBMED   12526743
REFERENCE   9  (bases 1 to 3667)
  AUTHORS   Carmell,M.A., Xuan,Z., Zhang,M.Q. and Hannon,G.J.
  TITLE     The Argonaute family: tentacles that reach into RNAi, developmental
            control, stem cell maintenance, and tumorigenesis
  JOURNAL   Genes Dev. 16 (21), 2733-2742 (2002)
   PUBMED   12414724
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BF979526.1, AL139286.13,
            AL138787.11, AK303929.1, BX104163.1 and AA251146.1.
            On Feb 25, 2011 this sequence version replaced gi:29294646.
            
            Summary: This gene encodes a member of the Argonaute family of
            proteins which play a role in RNA interference. The encoded protein
            is highly basic, contains a PAZ domain and a PIWI domain, and may
            play a role in short-interfering-RNA-mediated gene silencing. This
            gene is located on chromosome 1 in a tandem cluster of closely
            related family members including argonaute 4 and eukaryotic
            translation initiation factor 2C, 1. Two transcript variants
            encoding distinct isoforms have been identified for this gene.
            [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the longer
            transcript, and encodes the longer isoform (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK292870.1, AK022827.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           ERS025081, ERS025085 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-93                BF979526.1         6-98
            94-364              AL139286.13        66595-66865         c
            365-536             AL139286.13        52177-52348         c
            537-657             AL139286.13        30965-31085         c
            658-866             AL139286.13        25808-26016         c
            867-1003            AL139286.13        24529-24665         c
            1004-1138           AL138787.11        121593-121727       c
            1139-1226           AL138787.11        117291-117378       c
            1227-1374           AL138787.11        117024-117171       c
            1375-1494           AL138787.11        116474-116593       c
            1495-1617           AL138787.11        112316-112438       c
            1618-1751           AL138787.11        112020-112153       c
            1752-1936           AL138787.11        98770-98954         c
            1937-2096           AL138787.11        91735-91894         c
            2097-2187           AL138787.11        89801-89891         c
            2188-2382           AL138787.11        86084-86278         c
            2383-2517           AL138787.11        85627-85761         c
            2518-2617           AL138787.11        82522-82621         c
            2618-3174           AK303929.1         1902-2458
            3175-3433           BX104163.1         14-272              c
            3434-3667           AA251146.1         1-234               c
FEATURES             Location/Qualifiers
     source          1..3667
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p34"
     gene            1..3667
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /note="argonaute RISC catalytic component 3"
                     /db_xref="GeneID:192669"
                     /db_xref="HGNC:18421"
                     /db_xref="HPRD:09558"
                     /db_xref="MIM:607355"
     exon            1..364
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /inference="alignment:Splign:1.39.8"
     variation       20
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:148583974"
     variation       107
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:368650571"
     variation       267
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:372333004"
     variation       294
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:376997221"
     variation       304
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:375614115"
     variation       332
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:367620032"
     variation       341
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:1137693"
     misc_feature    343..345
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /note="upstream in-frame stop codon"
     CDS             346..2928
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /note="isoform a is encoded by transcript variant 1;
                     argonaute 3; protein argonaute-3; hAgo3; eIF2C 3; eIF-2C
                     3; argonaute3; eukaryotic translation initiation factor
                     2C, 3"
                     /codon_start=1
                     /product="protein argonaute-3 isoform a"
                     /protein_id="NP_079128.2"
                     /db_xref="GI:29294647"
                     /db_xref="CCDS:CCDS399.1"
                     /db_xref="GeneID:192669"
                     /db_xref="HGNC:18421"
                     /db_xref="HPRD:09558"
                     /db_xref="MIM:607355"
                     /translation="

MEIGSAGPAGAQPLLMVPRRPGYGTMGKPIKLLANCFQVEIPKIDVYLYEVDIKPDKCPRRVNREVVDSMVQHFKVTIFGDRRPVYDGKRSLYTANPLPVATTGVDLDVTLPGEGGKDRPFKVSIKFVSRVSWHLLHEVLTGRTLPEPLELDKPISTNPVHAVDVVLRHLPSMKYTPVGRSFFSAPEGYDHPLGGGREVWFGFHQSVRPAMWKMMLNIDVSATAFYKAQPVIQFMCEVLDIHNIDEQPRPLTDSHRVKFTKEIKGLKVEVTHCGTMRRKYRVCNVTRRPASHQTFPLQLENGQTVERTVAQYFREKYTLQLKYPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKKLTDNQTSTMIKATARSAPDRQEEISRLVRSANYETDPFVQEFQFKVRDEMAHVTGRVLPAPMLQYGGRNRTVATPSHGVWDMRGKQFHTGVEIKMWAIACFATQRQCREEILKGFTDQLRKISKDAGMPIQGQPCFCKYAQGADSVEPMFRHLKNTYSGLQLIIVILPGKTPVYAEVKRVGDTLLGMATQCVQVKNVIKTSPQTLSNLCLKINVKLGGINNILVPHQRPSVFQQPVIFLGADVTHPPAGDGKKPSIAAVVGSMDAHPSRYCATVRVQRPRQEIIQDLASMVRELLIQFYKSTRFKPTRIIFYRDGVSEGQFRQVLYYELLAIREACISLEKDYQPGITYIVVQKRHHTRLFCADRTERVGRSGNIPAGTTVDTDITHPYEFDFYLCSHAGIQGTSRPSHYHVLWDDNCFTADELQLLTYQLCHTYVRCTRSVSIPAPAYYAHLVAFRARYHLVDKEHDSAEGSHVSGQSNGRDPQALAKAVQIHQDTLRTMYFA

"
     misc_feature    403..2922
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /note="protein argonaute; Provisional; Region: PLN03202"
                     /db_xref="CDD:178743"
     misc_feature    871..1029
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /note="Domain of unknown function (DUF1785); Region:
                     DUF1785; pfam08699"
                     /db_xref="CDD:204029"
     misc_feature    1027..1389
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /note="PAZ domain, argonaute_like subfamily. Argonaute is
                     part of the RNA-induced silencing complex (RISC), and is
                     an endonuclease that plays a key role in the RNA
                     interference pathway. The PAZ domain has been named after
                     the proteins Piwi,Argonaut, and Zwille; Region:
                     PAZ_argonaute_like; cd02846"
                     /db_xref="CDD:30331"
     misc_feature    order(1183..1185,1228..1230,1270..1272,1282..1284,
                     1336..1338,1357..1359,1363..1365)
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /note="nucleic acid-binding interface [nucleotide
                     binding]; other site"
                     /db_xref="CDD:30331"
     misc_feature    1522..2799
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /note="Piwi_ago-like: PIWI domain, Argonaute-like
                     subfamily. Argonaute is the central component of the
                     RNA-induced silencing complex (RISC) and related
                     complexes. The PIWI domain is the C-terminal portion of
                     Argonaute and consists of two subdomains, one of...;
                     Region: Piwi_ago-like; cd04657"
                     /db_xref="CDD:72942"
     misc_feature    order(1933..1935,1945..1947,1981..1992,1999..2001,
                     2023..2025,2032..2034,2044..2046,2056..2058)
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /note="5' RNA guide strand anchoring site; other site"
                     /db_xref="CDD:72942"
     misc_feature    order(2137..2139,2143..2145,2353..2355,2767..2769)
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /note="active site"
                     /db_xref="CDD:72942"
     variation       364
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:371705852"
     exon            365..536
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /inference="alignment:Splign:1.39.8"
     variation       374
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:141269853"
     variation       382
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:139647049"
     variation       393
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:372140569"
     variation       397
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:147640766"
     variation       426
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:377039064"
     variation       485
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:369710801"
     exon            537..657
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /inference="alignment:Splign:1.39.8"
     variation       557
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:149655967"
     variation       589
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:372659384"
     variation       625
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:76534849"
     variation       627
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:375889312"
     variation       632
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:188633282"
     variation       641
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:372940279"
     variation       646
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:376214314"
     exon            658..866
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /inference="alignment:Splign:1.39.8"
     variation       714
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:148843760"
     variation       774
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:370300022"
     variation       777
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:146858503"
     variation       783
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:189436392"
     variation       801
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:78625682"
     variation       832
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:145896554"
     variation       855
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:140942553"
     variation       856
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:374759763"
     exon            867..1003
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /inference="alignment:Splign:1.39.8"
     variation       916
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:367796824"
     variation       918
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:147480778"
     variation       967
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:143581788"
     exon            1004..1138
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /inference="alignment:Splign:1.39.8"
     variation       1072
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:368190615"
     variation       1112
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:369030612"
     exon            1139..1226
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /inference="alignment:Splign:1.39.8"
     variation       1175
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:202072346"
     variation       1203
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:148681750"
     exon            1227..1374
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /inference="alignment:Splign:1.39.8"
     variation       1249
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201043874"
     variation       1269
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200735551"
     variation       1304
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:372692110"
     variation       1316
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:369662141"
     variation       1317
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:144067198"
     variation       1347
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:74645199"
     variation       1361
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:75667149"
     exon            1375..1494
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /inference="alignment:Splign:1.39.8"
     variation       1377
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:76924555"
     exon            1495..1617
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /inference="alignment:Splign:1.39.8"
     variation       1516
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201835772"
     variation       1532
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:149225833"
     variation       1554
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:41267265"
     exon            1618..1751
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /inference="alignment:Splign:1.39.8"
     variation       1744
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:147063309"
     variation       1747
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:368638136"
     exon            1752..1936
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /inference="alignment:Splign:1.39.8"
     variation       1846
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:199811357"
     variation       1887
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:111591152"
     variation       1906
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:143644991"
     variation       1917
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:138501451"
     exon            1937..2096
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /inference="alignment:Splign:1.39.8"
     variation       1949
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:369221869"
     variation       1972
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:373440270"
     variation       1979
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:200928613"
     variation       1995
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:144600568"
     variation       2005
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:143959736"
     variation       2019
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:111936785"
     variation       2061
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:377736680"
     exon            2097..2187
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /inference="alignment:Splign:1.39.8"
     variation       2118
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:139849193"
     variation       2136
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:151098893"
     variation       2139
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:140083661"
     variation       2148
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:149864052"
     exon            2188..2382
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /inference="alignment:Splign:1.39.8"
     variation       2205
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201570403"
     variation       2215..2216
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /replace=""
                     /replace="a"
                     /db_xref="dbSNP:34104798"
     variation       2277
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:147699389"
     variation       2304
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:143283288"
     variation       2343
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:373780763"
     exon            2383..2517
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /inference="alignment:Splign:1.39.8"
     variation       2405..2406
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /replace=""
                     /replace="c"
                     /db_xref="dbSNP:5773515"
     variation       2462
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:138068024"
     variation       2472
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:368356934"
     exon            2518..2619
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /inference="alignment:Splign:1.39.8"
     variation       2554
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:370775699"
     variation       2586
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:145947091"
     exon            2620..2819
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /inference="alignment:Splign:1.39.8"
     variation       2688
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:79043007"
     variation       2718
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:148771081"
     exon            2820..3645
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /inference="alignment:Splign:1.39.8"
     variation       2822
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:111316219"
     variation       2865
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:376625988"
     variation       2922
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:61743816"
     variation       2953
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:372307716"
     STS             3008..3226
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /standard_name="SHGC-74579"
                     /db_xref="UniSTS:44843"
     variation       3167
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:181505762"
     variation       3173
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:144063400"
     variation       3340
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:186097878"
     variation       3371
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:190878180"
     STS             3475..3599
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /standard_name="RH102469"
                     /db_xref="UniSTS:96803"
     variation       3477
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:145974637"
     variation       3495
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:184219370"
     variation       3509..3510
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /replace=""
                     /replace="t"
                     /db_xref="dbSNP:150584454"
     variation       3635
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:140115844"
     polyA_site      3645
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
ORIGIN      

gagcttccggggcggccccgggcaggtcggcggcggcggcccgcagtcgtggaggagcggtgggagcgtcggcggccgcgggcgatgcaacttccggacgggactcccctctgtccgcgcctcacatctccccttcctctcgcctagtcctgtgccgttttccgtccgcgactcttccggcccagagctttcggagtgcggttgctcaggggaagccgtcgccgcccccgcctcggggccgagtgagagtgcccgtcgcgtcgcgccgcgtcgccccccgggccgcctccttgccgccagtggcgggctccgttctccctcgaagcactccccccagctccatgaatggaaatcggctccgcaggacccgctggggcccagcccctactcatggtgcccagaagacctggctatggcaccatgggcaaacccattaaactgctggctaactgttttcaagttgaaatcccaaagattgatgtctacctctatgaggtagatattaaaccagacaagtgtcctaggagagtgaacagggaggtggttgactcaatggttcagcattttaaagtaactatatttggagaccgtagaccagtttatgatggaaaaagaagtctttacaccgccaatccacttcctgtggcaactacaggggtagatttagacgttactttacctggggaaggtggaaaagatcgacctttcaaggtgtcaatcaaatttgtctctcgggtgagttggcacctactgcatgaagtactgacaggacggaccttgcctgagccactggaattagacaagccaatcagcactaaccctgtccatgccgttgatgtggtgctacgacatctgccctccatgaaatacacacctgtggggcgttcatttttctccgctccagaaggatatgaccaccctctgggagggggcagggaagtgtggtttggattccatcagtctgttcggcctgccatgtggaaaatgatgcttaatatcgatgtttctgccactgccttctacaaagcacaacctgtaattcagttcatgtgtgaagttcttgatattcataatattgatgagcaaccaagacctctgactgattctcatcgggtaaaattcaccaaagagataaaaggtttgaaggttgaagtgactcattgtggaacaatgagacggaaataccgtgtttgtaatgtaacaaggaggcctgccagtcatcaaacctttcctttacagttagaaaacggccaaactgtggagagaacagtagcgcagtatttcagagaaaagtatactcttcagctgaagtacccgcaccttccctgtctgcaagtcgggcaggaacagaaacacacctacctgccactagaagtctgtaatattgtggcagggcaacgatgtatcaagaagctaacagacaatcagacttccactatgatcaaggcaacagcaagatctgcaccagatagacaagaggaaattagcagattggtaagaagtgcaaattatgaaacagatccatttgttcaggagtttcaatttaaagttcgggatgaaatggctcatgtaactggacgcgtacttccagcacctatgctccagtatggaggacggaatcggacagtagcaacaccgagccatggagtatgggacatgcgagggaaacaattccacacaggagttgaaatcaaaatgtgggctatcgcttgttttgccacacagaggcagtgcagagaagaaatattgaagggtttcacagaccagctgcgtaagatttctaaggatgcagggatgcccatccagggccagccatgcttctgcaaatatgcacagggggcagacagcgtagagcccatgttccggcatctcaagaacacatattctggcctacagcttattatcgtcatcctgccggggaagacaccagtgtatgcggaagtgaaacgtgtaggagacacacttttgggtatggctacacaatgtgttcaagtcaagaatgtaataaaaacatctcctcaaactctgtcaaacttgtgcctaaagataaatgttaaactcggagggatcaataatattcttgtacctcatcaaagaccttctgtgttccagcaaccagtgatctttttgggagccgatgtcactcatccacctgctggtgatggaaagaagccttctattgctgctgttgtaggtagtatggatgcacacccaagcagatactgtgccacagtaagagttcagagaccccgacaggagatcatccaggacttggcctccatggtccgggaacttcttattcaattttataagtcaactcggttcaagcctactcgtatcatcttttatcgggatggtgtttcagaggggcagtttaggcaggtattatattatgaactactagcaattcgagaagcctgcatcagtttggagaaagactatcaacctggaataacctacattgtagttcagaagagacatcacactcgattattttgtgctgataggacagaaagggttggaagaagtggcaatatcccagctggaacaacagttgatacagacattacacacccatatgagttcgatttttacctctgtagccatgctggaatacagggtaccagtcgtccttcacactatcatgttttatgggatgataactgctttactgcagatgaacttcagctgctaacttaccagctctgccacacttacgtacgctgtacacgatctgtttctatacctgcaccagcgtattatgctcacctggtagcatttagagccagatatcatcttgtggacaaagaacatgacagtgctgaaggaagtcacgtttcaggacaaagcaatgggcgagatccacaagctcttgccaaggctgtacagattcaccaagataccttacgcacaatgtacttcgcttaaatagtccaagtatattctctgagaggaagtactgaaagatgaattgacatacaacgtatgtttccagtgaagtcaattgagtaaggacacctccagccatacagaaaccaacactgtgtgggggccaaggtctgatccttatgttaatacaaggaagattgtttacttcatcaaggaacacagcatcattatgcaatatgaaaccagccaactgctttttgtgcggtctcctataggaagtatcgcaattgttttgttttcatttcttgtagtctaacccttttaatgcctttacctcaagttgcttggcagcacaactatctttgcaaaaaaaagtaaagaaaaagtaaatgatggtttaaaaaatacacaccttcatgaataatcaaagtgatttttcagaattatgtgtgcaaaaaattaatgtgcattcatatattcttgtaaaaggtgtctgtgtatttttaaaatatatacatccatacttcatatgcatatatatctagatctggattgataatagatatatatgtgtctgttatatattttagagttcattccattggggaattttctttcccttttattctacccccactaccgcctttatttctctatttcccttgccttcatcacctacatttttttcccagtcctaccagtgacattcaaatgttgatgtatctggttcgtttgaatataaaatatggcaaactaaaaaaaaaaaaaaaaaaaaaaa

//

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:192669 -> Molecular function: GO:0003723 [RNA binding] evidence: IEA
            GeneID:192669 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
            GeneID:192669 -> Biological process: GO:0006402 [mRNA catabolic process] evidence: IDA
            GeneID:192669 -> Biological process: GO:0007173 [epidermal growth factor receptor signaling pathway] evidence: TAS
            GeneID:192669 -> Biological process: GO:0007219 [Notch signaling pathway] evidence: TAS
            GeneID:192669 -> Biological process: GO:0008543 [fibroblast growth factor receptor signaling pathway] evidence: TAS
            GeneID:192669 -> Biological process: GO:0010467 [gene expression] evidence: TAS
            GeneID:192669 -> Biological process: GO:0035278 [negative regulation of translation involved in gene silencing by miRNA] evidence: IDA
            GeneID:192669 -> Biological process: GO:0038095 [Fc-epsilon receptor signaling pathway] evidence: TAS
            GeneID:192669 -> Biological process: GO:0045087 [innate immune response] evidence: TAS
            GeneID:192669 -> Biological process: GO:0048011 [neurotrophin TRK receptor signaling pathway] evidence: TAS
            GeneID:192669 -> Biological process: GO:0048015 [phosphatidylinositol-mediated signaling] evidence: TAS
            GeneID:192669 -> Biological process: GO:0072091 [regulation of stem cell proliferation] evidence: IMP
            GeneID:192669 -> Cellular component: GO:0000932 [cytoplasmic mRNA processing body] evidence: IEA
            GeneID:192669 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
            GeneID:192669 -> Cellular component: GO:0035068 [micro-ribonucleoprotein complex] evidence: IEA