GGRNA | NM_024501.2

LOCUS       NM_024501               1991 bp    mRNA    linear   PRI 20-APR-2013
DEFINITION  Homo sapiens homeobox D1 (HOXD1), mRNA.
ACCESSION   NM_024501
VERSION     NM_024501.2  GI:399154168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1991)
  AUTHORS   Faryna,M., Konermann,C., Aulmann,S., Bermejo,J.L., Brugger,M.,
            Diederichs,S., Rom,J., Weichenhan,D., Claus,R., Rehli,M.,
            Schirmacher,P., Sinn,H.P., Plass,C. and Gerhauser,C.
  TITLE     Genome-wide methylation screen in low-grade breast cancer
            identifies novel epigenetically altered genes as potential
            biomarkers for tumor diagnosis
  JOURNAL   FASEB J. 26 (12), 4937-4950 (2012)
   PUBMED   22930747
  REMARK    GeneRIF: Data indicate that median methylation levels of BCAN,
            HOXD1, KCTD8, KLF11, NXPH1, POU4F1, SIM1, and TCF7L1 were >/=30%
            higher than in normal samples, representing potential biomarkers
            for tumor diagnosis.
REFERENCE   2  (bases 1 to 1991)
  AUTHORS   Park,H., Choi,H.J., Kim,J., Kim,M., Rho,S.S., Hwang,D., Kim,Y.M.
            and Kwon,Y.G.
  TITLE     Homeobox D1 regulates angiogenic functions of endothelial cells via
            integrin beta1 expression
  JOURNAL   Biochem. Biophys. Res. Commun. 408 (1), 186-192 (2011)
   PUBMED   21501586
  REMARK    GeneRIF: HOXD1 plays a significant role in endothelial cells
            functions by regulating the expression of ITGB1.
REFERENCE   3  (bases 1 to 1991)
  AUTHORS   Goode,E.L., Chenevix-Trench,G., Song,H., Ramus,S.J., Notaridou,M.,
            Lawrenson,K., Widschwendter,M., Vierkant,R.A., Larson,M.C.,
            Kjaer,S.K., Birrer,M.J., Berchuck,A., Schildkraut,J., Tomlinson,I.,
            Kiemeney,L.A., Cook,L.S., Gronwald,J., Garcia-Closas,M., Gore,M.E.,
            Campbell,I., Whittemore,A.S., Sutphen,R., Phelan,C.,
            Anton-Culver,H., Pearce,C.L., Lambrechts,D., Rossing,M.A.,
            Chang-Claude,J., Moysich,K.B., Goodman,M.T., Dork,T.,
            Nevanlinna,H., Ness,R.B., Rafnar,T., Hogdall,C., Hogdall,E.,
            Fridley,B.L., Cunningham,J.M., Sieh,W., McGuire,V., Godwin,A.K.,
            Cramer,D.W., Hernandez,D., Levine,D., Lu,K., Iversen,E.S.,
            Palmieri,R.T., Houlston,R., van Altena,A.M., Aben,K.K.,
            Massuger,L.F., Brooks-Wilson,A., Kelemen,L.E., Le,N.D.,
            Jakubowska,A., Lubinski,J., Medrek,K., Stafford,A., Easton,D.F.,
            Tyrer,J., Bolton,K.L., Harrington,P., Eccles,D., Chen,A.,
            Molina,A.N., Davila,B.N., Arango,H., Tsai,Y.Y., Chen,Z.,
            Risch,H.A., McLaughlin,J., Narod,S.A., Ziogas,A., Brewster,W.,
            Gentry-Maharaj,A., Menon,U., Wu,A.H., Stram,D.O., Pike,M.C.,
            Beesley,J., Webb,P.M., Chen,X., Ekici,A.B., Thiel,F.C.,
            Beckmann,M.W., Yang,H., Wentzensen,N., Lissowska,J., Fasching,P.A.,
            Despierre,E., Amant,F., Vergote,I., Doherty,J., Hein,R.,
            Wang-Gohrke,S., Lurie,G., Carney,M.E., Thompson,P.J., Runnebaum,I.,
            Hillemanns,P., Durst,M., Antonenkova,N., Bogdanova,N., Leminen,A.,
            Butzow,R., Heikkinen,T., Stefansson,K., Sulem,P., Besenbacher,S.,
            Sellers,T.A., Gayther,S.A. and Pharoah,P.D.
  CONSRTM   Wellcome Trust Case-Control Consortium; Australian Cancer Study
            (Ovarian Cancer); Australian Ovarian Cancer Study Group; Ovarian
            Cancer Association Consortium (OCAC); Ovarian Cancer Association
            Consortium (OCAC)
  TITLE     A genome-wide association study identifies susceptibility loci for
            ovarian cancer at 2q31 and 8q24
  JOURNAL   Nat. Genet. 42 (10), 874-879 (2010)
   PUBMED   20852632
  REMARK    GeneRIF: Single nucleotide polymorphism in HOXD1 is associated with
            ovarian cancer.
            GeneRIF: Observational study and genome-wide association study of
            gene-disease association. (HuGE Navigator)
REFERENCE   4  (bases 1 to 1991)
  AUTHORS   Ester,A.R., Weymouth,K.S., Burt,A., Wise,C.A., Scott,A.,
            Gurnett,C.A., Dobbs,M.B., Blanton,S.H. and Hecht,J.T.
  TITLE     Altered transmission of HOX and apoptotic SNPs identify a potential
            common pathway for clubfoot
  JOURNAL   Am. J. Med. Genet. A 149A (12), 2745-2752 (2009)
   PUBMED   19938081
  REMARK    GeneRIF: Observational study of gene-disease association and
            gene-gene interaction. (HuGE Navigator)
REFERENCE   5  (bases 1 to 1991)
  AUTHORS   Yerges,L.M., Klei,L., Cauley,J.A., Roeder,K., Kammerer,C.M.,
            Moffett,S.P., Ensrud,K.E., Nestlerode,C.S., Marshall,L.M.,
            Hoffman,A.R., Lewis,C., Lang,T.F., Barrett-Connor,E., Ferrell,R.E.,
            Orwoll,E.S. and Zmuda,J.M.
  CONSRTM   MrOS Research Group
  TITLE     High-density association study of 383 candidate genes for
            volumetric BMD at the femoral neck and lumbar spine among older men
  JOURNAL   J. Bone Miner. Res. 24 (12), 2039-2049 (2009)
   PUBMED   19453261
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   6  (bases 1 to 1991)
  AUTHORS   Manohar,C.F., Salwen,H.R., Furtado,M.R. and Cohn,S.L.
  TITLE     Up-regulation of HOXC6, HOXD1, and HOXD8 homeobox gene expression
            in human neuroblastoma cells following chemical induction of
            differentiation
  JOURNAL   Tumour Biol. 17 (1), 34-47 (1996)
   PUBMED   7501971
REFERENCE   7  (bases 1 to 1991)
  AUTHORS   Guazzi,S., Lonigro,R., Pintonello,L., Boncinelli,E., Di Lauro,R.
            and Mavilio,F.
  TITLE     The thyroid transcription factor-1 gene is a candidate target for
            regulation by Hox proteins
  JOURNAL   EMBO J. 13 (14), 3339-3347 (1994)
   PUBMED   7913891
REFERENCE   8  (bases 1 to 1991)
  AUTHORS   Scott,M.P.
  TITLE     Vertebrate homeobox gene nomenclature
  JOURNAL   Cell 71 (4), 551-553 (1992)
   PUBMED   1358459
REFERENCE   9  (bases 1 to 1991)
  AUTHORS   McAlpine,P.J. and Shows,T.B.
  TITLE     Nomenclature for human homeobox genes
  JOURNAL   Genomics 7 (3), 460 (1990)
   PUBMED   1973146
REFERENCE   10 (bases 1 to 1991)
  AUTHORS   Boncinelli,E., Acampora,D., Pannese,M., D'Esposito,M., Somma,R.,
            Gaudino,G., Stornaiuolo,A., Cafiero,M., Faiella,A. and Simeone,A.
  TITLE     Organization of human class I homeobox genes
  JOURNAL   Genome 31 (2), 745-756 (1989)
   PUBMED   2576652
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF241528.1 and BC014477.1.
            On Aug 2, 2012 this sequence version replaced gi:13375631.
            
            Summary: This gene is a member of the Antp homeobox family and
            encodes a protein with a homeobox DNA-binding domain. This nuclear
            protein functions as a sequence-specific transcription factor that
            is involved in differentiation and limb development. Mutations in
            this gene have been associated with severe developmental defects on
            the anterior-posterior (a-p) limb axis. [provided by RefSeq, Jul
            2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF241528.1, AK314120.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           ERS025081, ERS025084 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-876               AF241528.1         1-876
            877-1991            BC014477.1         781-1895
FEATURES             Location/Qualifiers
     source          1..1991
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q31.1"
     gene            1..1991
                     /gene="HOXD1"
                     /gene_synonym="Hox-4.7; HOX4; HOX4G"
                     /note="homeobox D1"
                     /db_xref="GeneID:3231"
                     /db_xref="HGNC:5132"
                     /db_xref="HPRD:00870"
                     /db_xref="MIM:142987"
     exon            1..875
                     /gene="HOXD1"
                     /gene_synonym="Hox-4.7; HOX4; HOX4G"
                     /inference="alignment:Splign:1.39.8"
     variation       54
                     /gene="HOXD1"
                     /gene_synonym="Hox-4.7; HOX4; HOX4G"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:186339892"
     misc_feature    62..64
                     /gene="HOXD1"
                     /gene_synonym="Hox-4.7; HOX4; HOX4G"
                     /note="upstream in-frame stop codon"
     variation       120
                     /gene="HOXD1"
                     /gene_synonym="Hox-4.7; HOX4; HOX4G"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:150457564"
     CDS             224..1210
                     /gene="HOXD1"
                     /gene_synonym="Hox-4.7; HOX4; HOX4G"
                     /note="homeo box D1; homeo box 4G; homeobox protein
                     Hox-GG"
                     /codon_start=1
                     /product="homeobox protein Hox-D1"
                     /protein_id="NP_078777.1"
                     /db_xref="GI:13375632"
                     /db_xref="CCDS:CCDS2271.1"
                     /db_xref="GeneID:3231"
                     /db_xref="HGNC:5132"
                     /db_xref="HPRD:00870"
                     /db_xref="MIM:142987"
                     /translation="

MSSYLEYVSCSSSGGVGGDVLSLAPKFCRSDARPVALQPAFPLGNGDGAFVSCLPLAAARPSPSPPAAPARPSVPPPAAPQYAQCTLEGAYEPGAAPAAAAGGADYGFLGSGPAYDFPGVLGRAADDGGSHVHYATSAVFSGGGSFLLSGQVDYAAFGEPGPFPACLKASADGHPGAFQTASPAPGTYPKSVSPASGLPAAFSTFEWMKVKRNASKKGKLAEYGAASPSSAIRTNFSTKQLTELEKEFHFNKYLTRARRIEIANCLHLNDTQVKIWFQNRRMKQKKREREGLLATAIPVAPLQLPLSGTTPTKFIKNPGSPSQSQEPS

"
     misc_feature    833..850
                     /gene="HOXD1"
                     /gene_synonym="Hox-4.7; HOX4; HOX4G"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9GZZ0.1);
                     Region: Antp-type hexapeptide"
     misc_feature    920..1087
                     /gene="HOXD1"
                     /gene_synonym="Hox-4.7; HOX4; HOX4G"
                     /note="Homeodomain;  DNA binding domains involved in the
                     transcriptional regulation of key eukaryotic developmental
                     processes; may bind to DNA as monomers or as homo- and/or
                     heterodimers, in a sequence-specific manner; Region:
                     homeodomain; cd00086"
                     /db_xref="CDD:28970"
     misc_feature    order(920..925,929..931,980..982,998..1000,1037..1039,
                     1043..1048,1055..1060,1064..1072,1076..1081)
                     /gene="HOXD1"
                     /gene_synonym="Hox-4.7; HOX4; HOX4G"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:28970"
     misc_feature    order(926..928,1046..1048,1055..1060,1067..1069)
                     /gene="HOXD1"
                     /gene_synonym="Hox-4.7; HOX4; HOX4G"
                     /note="specific DNA base contacts [nucleotide binding];
                     other site"
                     /db_xref="CDD:28970"
     variation       263
                     /gene="HOXD1"
                     /gene_synonym="Hox-4.7; HOX4; HOX4G"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:144268439"
     variation       313
                     /gene="HOXD1"
                     /gene_synonym="Hox-4.7; HOX4; HOX4G"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:370320082"
     variation       316
                     /gene="HOXD1"
                     /gene_synonym="Hox-4.7; HOX4; HOX4G"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:372202598"
     variation       341
                     /gene="HOXD1"
                     /gene_synonym="Hox-4.7; HOX4; HOX4G"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:373779720"
     variation       349
                     /gene="HOXD1"
                     /gene_synonym="Hox-4.7; HOX4; HOX4G"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:368837616"
     variation       352
                     /gene="HOXD1"
                     /gene_synonym="Hox-4.7; HOX4; HOX4G"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:376811125"
     variation       553
                     /gene="HOXD1"
                     /gene_synonym="Hox-4.7; HOX4; HOX4G"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:369174324"
     variation       675
                     /gene="HOXD1"
                     /gene_synonym="Hox-4.7; HOX4; HOX4G"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:371113016"
     variation       713
                     /gene="HOXD1"
                     /gene_synonym="Hox-4.7; HOX4; HOX4G"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:17851168"
     variation       748
                     /gene="HOXD1"
                     /gene_synonym="Hox-4.7; HOX4; HOX4G"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:13390503"
     variation       752
                     /gene="HOXD1"
                     /gene_synonym="Hox-4.7; HOX4; HOX4G"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:372456292"
     variation       809
                     /gene="HOXD1"
                     /gene_synonym="Hox-4.7; HOX4; HOX4G"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:147120298"
     variation       814
                     /gene="HOXD1"
                     /gene_synonym="Hox-4.7; HOX4; HOX4G"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:375477049"
     variation       833
                     /gene="HOXD1"
                     /gene_synonym="Hox-4.7; HOX4; HOX4G"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:141997863"
     variation       875
                     /gene="HOXD1"
                     /gene_synonym="Hox-4.7; HOX4; HOX4G"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:150112597"
     exon            876..1975
                     /gene="HOXD1"
                     /gene_synonym="Hox-4.7; HOX4; HOX4G"
                     /inference="alignment:Splign:1.39.8"
     variation       883
                     /gene="HOXD1"
                     /gene_synonym="Hox-4.7; HOX4; HOX4G"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:200100987"
     variation       886
                     /gene="HOXD1"
                     /gene_synonym="Hox-4.7; HOX4; HOX4G"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:144526720"
     variation       887
                     /gene="HOXD1"
                     /gene_synonym="Hox-4.7; HOX4; HOX4G"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:202007469"
     variation       905
                     /gene="HOXD1"
                     /gene_synonym="Hox-4.7; HOX4; HOX4G"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201124895"
     variation       907
                     /gene="HOXD1"
                     /gene_synonym="Hox-4.7; HOX4; HOX4G"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:142635639"
     variation       909
                     /gene="HOXD1"
                     /gene_synonym="Hox-4.7; HOX4; HOX4G"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:374032063"
     variation       937
                     /gene="HOXD1"
                     /gene_synonym="Hox-4.7; HOX4; HOX4G"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:112900146"
     variation       956
                     /gene="HOXD1"
                     /gene_synonym="Hox-4.7; HOX4; HOX4G"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:201651666"
     variation       975
                     /gene="HOXD1"
                     /gene_synonym="Hox-4.7; HOX4; HOX4G"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:144229443"
     variation       1022
                     /gene="HOXD1"
                     /gene_synonym="Hox-4.7; HOX4; HOX4G"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:370435803"
     variation       1025
                     /gene="HOXD1"
                     /gene_synonym="Hox-4.7; HOX4; HOX4G"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:181672079"
     variation       1029
                     /gene="HOXD1"
                     /gene_synonym="Hox-4.7; HOX4; HOX4G"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:149800367"
     variation       1032
                     /gene="HOXD1"
                     /gene_synonym="Hox-4.7; HOX4; HOX4G"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:145794550"
     variation       1075
                     /gene="HOXD1"
                     /gene_synonym="Hox-4.7; HOX4; HOX4G"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:368491456"
     variation       1109
                     /gene="HOXD1"
                     /gene_synonym="Hox-4.7; HOX4; HOX4G"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:6710142"
     variation       1130
                     /gene="HOXD1"
                     /gene_synonym="Hox-4.7; HOX4; HOX4G"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:200230800"
     variation       1227..1228
                     /gene="HOXD1"
                     /gene_synonym="Hox-4.7; HOX4; HOX4G"
                     /replace=""
                     /replace="g"
                     /db_xref="dbSNP:199761075"
     variation       1237
                     /gene="HOXD1"
                     /gene_synonym="Hox-4.7; HOX4; HOX4G"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:371579717"
     variation       1346
                     /gene="HOXD1"
                     /gene_synonym="Hox-4.7; HOX4; HOX4G"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:186519463"
     variation       1433
                     /gene="HOXD1"
                     /gene_synonym="Hox-4.7; HOX4; HOX4G"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:6725515"
     variation       1499
                     /gene="HOXD1"
                     /gene_synonym="Hox-4.7; HOX4; HOX4G"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:190962453"
     variation       1639
                     /gene="HOXD1"
                     /gene_synonym="Hox-4.7; HOX4; HOX4G"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:182463194"
     variation       1708..1709
                     /gene="HOXD1"
                     /gene_synonym="Hox-4.7; HOX4; HOX4G"
                     /replace=""
                     /replace="t"
                     /db_xref="dbSNP:113261496"
     variation       1717..1718
                     /gene="HOXD1"
                     /gene_synonym="Hox-4.7; HOX4; HOX4G"
                     /replace=""
                     /replace="t"
                     /db_xref="dbSNP:71860310"
     variation       1718
                     /gene="HOXD1"
                     /gene_synonym="Hox-4.7; HOX4; HOX4G"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:11551009"
     STS             1751..1949
                     /gene="HOXD1"
                     /gene_synonym="Hox-4.7; HOX4; HOX4G"
                     /standard_name="RH68884"
                     /db_xref="UniSTS:111"
     variation       1885
                     /gene="HOXD1"
                     /gene_synonym="Hox-4.7; HOX4; HOX4G"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:185309130"
     polyA_signal    1955..1960
                     /gene="HOXD1"
                     /gene_synonym="Hox-4.7; HOX4; HOX4G"
     variation       1955
                     /gene="HOXD1"
                     /gene_synonym="Hox-4.7; HOX4; HOX4G"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:62188735"
     variation       1969
                     /gene="HOXD1"
                     /gene_synonym="Hox-4.7; HOX4; HOX4G"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:144962247"
     polyA_site      1975
                     /gene="HOXD1"
                     /gene_synonym="Hox-4.7; HOX4; HOX4G"
ORIGIN

gccgagcggagaggccgcccattggccggccagcgccacgtggccgcccccgccggtatattaggccactatttacctccggctcactcgccatgggttggagagggcagctcgggtagagagggctggcggagcggcgcagacggcggcagtcctgctcagcctctgcccggctccgtactccggccccggcctgcgccctcagaaaggtggggcccgaaccatgagctcctacctggagtacgtgtcatgcagcagcagcggcggggtcggcggcgacgtgctcagcttggcacccaagttctgccgctccgacgcccggcccgtggctctgcagcccgccttccctctgggcaacggcgacggcgccttcgtcagctgtctgcccctggccgccgcccgaccctcgccttcgcccccggccgcccccgcgcggccgtccgtaccgcctccggccgcgccccagtacgcgcagtgcaccctggagggggcctacgaacctggtgccgcacctgccgcggcagctgggggcgcggactacggcttcctggggtccgggccggcgtacgacttcccgggcgtgctggggcgggcggccgacgacggcgggtctcacgtccactacgccacctcggccgtcttctcgggcggcggctctttcctcctcagcggccaggtggattacgcggccttcggcgaacccggcccttttccggcttgtctcaaagcgtcagccgacggccaccctggtgctttccagaccgcatccccggccccaggcacctaccccaagtccgtctctcccgcctccggcctccctgccgccttcagcacgttcgagtggatgaaagtgaagaggaatgcctctaagaaaggcaaactcgccgagtatggggccgctagcccctccagcgcgatccgcacgaatttcagcaccaagcaactgacagaactggaaaaagagtttcatttcaataagtacttaactcgagcccggcgcatcgagatagccaactgcttgcacctgaatgacacgcaagtcaaaatctggttccagaaccgcaggatgaaacagaagaaaagggaacgagaagggcttctggccacggccattcctgtggctcccctccaacttcccctctctggaacaacccccactaagtttatcaagaaccccggcagcccttctcagtcccaagagccttcgtgaggccggtacttggggccgaaaaactgtggcctgcagaagtcccaggcgacccccatccctatctagacttaggagctcagtttgggatggaggtgggagaacaaaaatgaatagggatttcacttgggaaatgaagtactttagttggcttccgagttccagactatatgtccagatattaattgactgtcttgtaagccacttgtttggttatgatttgtgtcttatcagggaaaaggtgcccagctgccagcccagctccgctgctatctttgcctcacttagtcatgtgcaattcgcgttgcagagtggcagaccattagttgctgagttctgtcagcactctgatgtgctcagaagagcacctgcccaaagtttttctggttttaatttaaaggacaaggctacatatattcagctttttgagatgaccaaagctagttagggtctccttgatgtagctaagctgcttcagtgatcttcacatttgcactccagtttttttttctttaaaaaagcggtttctacctctctatgtgcctgagtgatgatacaatcgctgtttagttactagatgaacaaatccacagaatgggtaaagagtagaatctgaactatatcttgacaaatattattcaaacttgaatgtaaatatatacagtatgtatattttttaaaaagatttgcttgcaatgaccttataagtgacatttaatgtcatagcatgtaaagggttttttttgtaataaaaattatagaatctgcaaaaaaaaaaaaaaaa

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