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2024-03-29 00:07:53, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_024423               6978 bp    mRNA    linear   PRI 15-JUN-2013
DEFINITION  Homo sapiens desmocollin 3 (DSC3), transcript variant Dsc3b, mRNA.
ACCESSION   NM_024423
VERSION     NM_024423.2  GI:148539847
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6978)
  AUTHORS   Cui,T., Chen,Y., Yang,L., Knosel,T., Huber,O., Pacyna-Gengelbach,M.
            and Petersen,I.
  TITLE     The p53 target gene desmocollin 3 acts as a novel tumor suppressor
            through inhibiting EGFR/ERK pathway in human lung cancer
  JOURNAL   Carcinogenesis 33 (12), 2326-2333 (2012)
   PUBMED   22941060
  REMARK    GeneRIF: The p53 target gene desmocollin 3 acts as a novel tumor
            suppressor through inhibiting EGFR/ERK pathway in human lung
            cancer.
REFERENCE   2  (bases 1 to 6978)
  AUTHORS   Knosel,T., Chen,Y., Hotovy,S., Settmacher,U., Altendorf-Hofmann,A.
            and Petersen,I.
  TITLE     Loss of desmocollin 1-3 and homeobox genes PITX1 and CDX2 are
            associated with tumor progression and survival in colorectal
            carcinoma
  JOURNAL   Int J Colorectal Dis 27 (11), 1391-1399 (2012)
   PUBMED   22438068
  REMARK    GeneRIF: High expression of desmocollin 1 (DSC1) was observed in
            41.6%, DSC2 in 58.0%, DSC3 in 61.4%, E-cadherin in 71.4%, CDX2 in
            58.0%, PITX1 in 55.0%, CDK4 in 0.2%, TLE1 in 1.3%, Factor H in
            42.5%, and MDM2 in 0.2% of colorectal carcinomas.
REFERENCE   3  (bases 1 to 6978)
  AUTHORS   Comuzzie,A.G., Cole,S.A., Laston,S.L., Voruganti,V.S., Haack,K.,
            Gibbs,R.A. and Butte,N.F.
  TITLE     Novel genetic loci identified for the pathophysiology of childhood
            obesity in the Hispanic population
  JOURNAL   PLoS ONE 7 (12), E51954 (2012)
   PUBMED   23251661
REFERENCE   4  (bases 1 to 6978)
  AUTHORS   Cui,T., Chen,Y., Yang,L., Knosel,T., Zoller,K., Huber,O. and
            Petersen,I.
  TITLE     DSC3 expression is regulated by p53, and methylation of DSC3 DNA is
            a prognostic marker in human colorectal cancer
  JOURNAL   Br. J. Cancer 104 (6), 1013-1019 (2011)
   PUBMED   21364582
  REMARK    GeneRIF: Methylation status of DSC3 DNA is a prognostic marker for
            colorectal cancer. P53 appears to have an important role in
            regulating DSC3 expression.
REFERENCE   5  (bases 1 to 6978)
  AUTHORS   Whittock,N.V., Hunt,D.M., Rickman,L., Malhi,S., Vogazianou,A.P.,
            Dawson,L.F., Eady,R.A., Buxton,R.S. and McGrath,J.A.
  TITLE     Genomic organization and amplification of the human desmosomal
            cadherin genes DSC1 and DSC3, encoding desmocollin types 1 and 3
  JOURNAL   Biochem. Biophys. Res. Commun. 276 (2), 454-460 (2000)
   PUBMED   11027496
REFERENCE   6  (bases 1 to 6978)
  AUTHORS   King,I.A., Sullivan,K.H., Bennett,R. Jr. and Buxton,R.S.
  TITLE     The desmocollins of human foreskin epidermis: identification and
            chromosomal assignment of a third gene and expression patterns of
            the three isoforms
  JOURNAL   J. Invest. Dermatol. 105 (3), 314-321 (1995)
   PUBMED   7665906
REFERENCE   7  (bases 1 to 6978)
  AUTHORS   Amagai,M., Wang,Y., Minoshima,S., Kawamura,K., Green,K.J.,
            Nishikawa,T. and Shimizu,N.
  TITLE     Assignment of the human genes for desmocollin 3 (DSC3) and
            desmocollin 4 (DSC4) to chromosome 18q12
  JOURNAL   Genomics 25 (1), 330-332 (1995)
   PUBMED   7774948
REFERENCE   8  (bases 1 to 6978)
  AUTHORS   Kawamura,K., Watanabe,K., Suzuki,T., Yamakawa,T., Kamiyama,T.,
            Nakagawa,H. and Tsurufuji,S.
  TITLE     cDNA cloning and expression of a novel human desmocollin
  JOURNAL   J. Biol. Chem. 269 (42), 26295-26302 (1994)
   PUBMED   7929347
REFERENCE   9  (bases 1 to 6978)
  AUTHORS   Buxton,R.S., Wheeler,G.N., Pidsley,S.C., Marsden,M.D., Adams,M.J.,
            Jenkins,N.A., Gilbert,D.J. and Copeland,N.G.
  TITLE     Mouse desmocollin (Dsc3) and desmoglein (Dsg1) genes are closely
            linked in the proximal region of chromosome 18
  JOURNAL   Genomics 21 (3), 510-516 (1994)
   PUBMED   7959727
REFERENCE   10 (bases 1 to 6978)
  AUTHORS   Arnemann,J., Spurr,N.K., Wheeler,G.N., Parker,A.E. and Buxton,R.S.
  TITLE     Chromosomal assignment of the human genes coding for the major
            proteins of the desmosome junction, desmoglein DGI (DSG),
            desmocollins DGII/III (DSC), desmoplakins DPI/II (DSP), and
            plakoglobin DPIII (JUP)
  JOURNAL   Genomics 10 (3), 640-645 (1991)
   PUBMED   1889810
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC025212.5, D17427.1 and
            BG697535.1.
            This sequence is a reference standard in the RefSeqGene project.
            On Jun 2, 2007 this sequence version replaced gi:13435368.
            
            Summary: The protein encoded by this gene is a calcium-dependent
            glycoprotein that is a member of the desmocollin subfamily of the
            cadherin superfamily. These desmosomal family members, along with
            the desmogleins, are found primarily in epithelial cells where they
            constitute the adhesive proteins of the desmosome cell-cell
            junction and are required for cell adhesion and desmosome
            formation. The desmosomal family members are arranged in two
            clusters on chromosome 18, occupying less than 650 kb combined.
            Alternative splicing results in two transcript variants encoding
            distinct isoforms. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (Dsc3b) represents the longer
            transcript, which includes all 17 exons and encodes the shorter
            isoform (Dsc3b). There are no publicly available full-length
            transcripts representing this variant, but it is supported by mRNA
            annotation on DNA accession AF293359.1, and by data in PMIDs
            7929347 and 11027496.
            
            Sequence Note: This RefSeq record was created from transcript and
            genome sequence data because no single transcript was available for
            the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed/partial sample support ERS025081, ERS025083
                              [ECO:0000350]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-104               AC025212.5         180619-180722       c
            105-2648            D17427.1           17-2560
            2649-2690           BG697535.1         618-659
            2691-2691           BG697535.1         661-661
            2692-3151           D17427.1           2561-3020
            3152-6978           AC025212.5         127993-131819       c
FEATURES             Location/Qualifiers
     source          1..6978
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="18"
                     /map="18q12.1"
     gene            1..6978
                     /gene="DSC3"
                     /gene_synonym="CDHF3; DSC; DSC1; DSC2; DSC4; HT-CP"
                     /note="desmocollin 3"
                     /db_xref="GeneID:1825"
                     /db_xref="HGNC:3037"
                     /db_xref="MIM:600271"
     exon            1..224
                     /gene="DSC3"
                     /gene_synonym="CDHF3; DSC; DSC1; DSC2; DSC4; HT-CP"
                     /inference="alignment:Splign:1.39.8"
     CDS             156..2675
                     /gene="DSC3"
                     /gene_synonym="CDHF3; DSC; DSC1; DSC2; DSC4; HT-CP"
                     /note="isoform Dsc3b preproprotein is encoded by
                     transcript variant Dsc3b; desmocollin-4; cadherin family
                     member 3"
                     /codon_start=1
                     /product="desmocollin-3 isoform Dsc3b preproprotein"
                     /protein_id="NP_077741.2"
                     /db_xref="GI:148539848"
                     /db_xref="GeneID:1825"
                     /db_xref="HGNC:3037"
                     /db_xref="MIM:600271"
                     /translation="
MAAAGPRRSVRGAVCLHLLLTLVIFSRAGEACKKVILNVPSKLEADKIIGRVNLEECFRSADLIRSSDPDFRVLNDGSVYTARAVALSDKKRSFTIWLSDKRKQTQKEVTVLLEHQKKVSKTRHTRETVLRRAKRRWAPIPCSMQENSLGPFPLFLQQVESDAAQNYTVFYSISGRGVDKEPLNLFYIERDTGNLFCTRPVDREEYDVFDLIAYASTADGYSADLPLPLPIRVEDENDNHPVFTEAIYNFEVLESSRPGTTVGVVCATDRDEPDTMHTRLKYSILQQTPRSPGLFSVHPSTGVITTVSHYLDREVVDKYSLIMKVQDMDGQFFGLIGTSTCIITVTDSNDNAPTFRQNAYEAFVEENAFNVEILRIPIEDKDLINTANWRVNFTILKGNENGHFKISTDKETNEGVLSVVKPLNYEENRQVNLEIGVNNEAPFARDIPRVTALNRALVTVHVRDLDEGPECTPAAQYVRIKENLAVGSKINGYKAYDPENRNGNGLRYKKLHDPKGWITIDEISGSIITSKILDREVETPKNELYNITVLAIDKDDRSCTGTLAVNIEDVNDNPPEILQEYVVICKPKMGYTDILAVDPDEPVHGAPFYFSLPNTSPEISRLWSLTKVNDTAARLSYQKNAGFQEYTIPITVKDRAGQAATKLLRVNLCECTHPTQCRATSRSTGVILGKWAILAILLGIALLFSVLLTLVCGVFGATKGKRFPEDLAQQNLIISNTEAPGDDRVCSANGFMTQTTNNSSQGFCGTMGSGMKNGGQETIEMMKGGNQTLESCRGAGHHHTLDSCRGGHTEVDNCRYTYSEWHSFTQPRLGEESIRGHTG
"
     sig_peptide     156..236
                     /gene="DSC3"
                     /gene_synonym="CDHF3; DSC; DSC1; DSC2; DSC4; HT-CP"
     misc_feature    234..488
                     /gene="DSC3"
                     /gene_synonym="CDHF3; DSC; DSC1; DSC2; DSC4; HT-CP"
                     /note="Cadherin prodomain like; Region: Cadherin_pro;
                     smart01055"
                     /db_xref="CDD:198123"
     proprotein      237..2672
                     /gene="DSC3"
                     /gene_synonym="CDHF3; DSC; DSC1; DSC2; DSC4; HT-CP"
                     /product="desmocollin-3 isoform Dsc3b proprotein"
     misc_feature    432..434
                     /gene="DSC3"
                     /gene_synonym="CDHF3; DSC; DSC1; DSC2; DSC4; HT-CP"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     mat_peptide     561..2672
                     /gene="DSC3"
                     /gene_synonym="CDHF3; DSC; DSC1; DSC2; DSC4; HT-CP"
                     /product="desmocollin-3 isoform Dsc3b"
     misc_feature    order(591..596,759..761,765..767,858..860,864..869)
                     /gene="DSC3"
                     /gene_synonym="CDHF3; DSC; DSC1; DSC2; DSC4; HT-CP"
                     /note="Ca2+ binding site [ion binding]; other site"
                     /db_xref="CDD:206635"
     misc_feature    630..878
                     /gene="DSC3"
                     /gene_synonym="CDHF3; DSC; DSC1; DSC2; DSC4; HT-CP"
                     /note="Cadherin repeats; Region: CA; smart00112"
                     /db_xref="CDD:197520"
     misc_feature    894..1208
                     /gene="DSC3"
                     /gene_synonym="CDHF3; DSC; DSC1; DSC2; DSC4; HT-CP"
                     /note="Cadherin tandem repeat domain; Region:
                     Cadherin_repeat; cd11304"
                     /db_xref="CDD:206637"
     misc_feature    order(915..920,1089..1091,1095..1097,1194..1196,
                     1200..1205)
                     /gene="DSC3"
                     /gene_synonym="CDHF3; DSC; DSC1; DSC2; DSC4; HT-CP"
                     /note="Ca2+ binding site [ion binding]; other site"
                     /db_xref="CDD:206637"
     misc_feature    1233..1547
                     /gene="DSC3"
                     /gene_synonym="CDHF3; DSC; DSC1; DSC2; DSC4; HT-CP"
                     /note="Cadherin tandem repeat domain; Region:
                     Cadherin_repeat; cd11304"
                     /db_xref="CDD:206637"
     misc_feature    order(1251..1256,1425..1427,1431..1433,1545..1547)
                     /gene="DSC3"
                     /gene_synonym="CDHF3; DSC; DSC1; DSC2; DSC4; HT-CP"
                     /note="Ca2+ binding site [ion binding]; other site"
                     /db_xref="CDD:206637"
     misc_feature    1584..1874
                     /gene="DSC3"
                     /gene_synonym="CDHF3; DSC; DSC1; DSC2; DSC4; HT-CP"
                     /note="Cadherin tandem repeat domain; Region:
                     Cadherin_repeat; cd11304"
                     /db_xref="CDD:206637"
     misc_feature    order(1599..1604,1755..1757,1761..1763,1860..1862,
                     1866..1871)
                     /gene="DSC3"
                     /gene_synonym="CDHF3; DSC; DSC1; DSC2; DSC4; HT-CP"
                     /note="Ca2+ binding site [ion binding]; other site"
                     /db_xref="CDD:206637"
     misc_feature    <1941..2162
                     /gene="DSC3"
                     /gene_synonym="CDHF3; DSC; DSC1; DSC2; DSC4; HT-CP"
                     /note="Cadherin repeat-like domain; Region: CA_like;
                     cl15786"
                     /db_xref="CDD:211469"
     misc_feature    2226..2288
                     /gene="DSC3"
                     /gene_synonym="CDHF3; DSC; DSC1; DSC2; DSC4; HT-CP"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q14574.3);
                     transmembrane region"
     exon            225..309
                     /gene="DSC3"
                     /gene_synonym="CDHF3; DSC; DSC1; DSC2; DSC4; HT-CP"
                     /inference="alignment:Splign:1.39.8"
     exon            310..509
                     /gene="DSC3"
                     /gene_synonym="CDHF3; DSC; DSC1; DSC2; DSC4; HT-CP"
                     /inference="alignment:Splign:1.39.8"
     variation       387
                     /gene="DSC3"
                     /gene_synonym="CDHF3; DSC; DSC1; DSC2; DSC4; HT-CP"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:276937"
     variation       460
                     /gene="DSC3"
                     /gene_synonym="CDHF3; DSC; DSC1; DSC2; DSC4; HT-CP"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:276938"
     exon            510..629
                     /gene="DSC3"
                     /gene_synonym="CDHF3; DSC; DSC1; DSC2; DSC4; HT-CP"
                     /inference="alignment:Splign:1.39.8"
     exon            630..785
                     /gene="DSC3"
                     /gene_synonym="CDHF3; DSC; DSC1; DSC2; DSC4; HT-CP"
                     /inference="alignment:Splign:1.39.8"
     variation       750
                     /gene="DSC3"
                     /gene_synonym="CDHF3; DSC; DSC1; DSC2; DSC4; HT-CP"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:276921"
     exon            786..930
                     /gene="DSC3"
                     /gene_synonym="CDHF3; DSC; DSC1; DSC2; DSC4; HT-CP"
                     /inference="alignment:Splign:1.39.8"
     exon            931..1097
                     /gene="DSC3"
                     /gene_synonym="CDHF3; DSC; DSC1; DSC2; DSC4; HT-CP"
                     /inference="alignment:Splign:1.39.8"
     exon            1098..1232
                     /gene="DSC3"
                     /gene_synonym="CDHF3; DSC; DSC1; DSC2; DSC4; HT-CP"
                     /inference="alignment:Splign:1.39.8"
     exon            1233..1418
                     /gene="DSC3"
                     /gene_synonym="CDHF3; DSC; DSC1; DSC2; DSC4; HT-CP"
                     /inference="alignment:Splign:1.39.8"
     exon            1419..1675
                     /gene="DSC3"
                     /gene_synonym="CDHF3; DSC; DSC1; DSC2; DSC4; HT-CP"
                     /inference="alignment:Splign:1.39.8"
     exon            1676..1818
                     /gene="DSC3"
                     /gene_synonym="CDHF3; DSC; DSC1; DSC2; DSC4; HT-CP"
                     /inference="alignment:Splign:1.39.8"
     exon            1819..2043
                     /gene="DSC3"
                     /gene_synonym="CDHF3; DSC; DSC1; DSC2; DSC4; HT-CP"
                     /inference="alignment:Splign:1.39.8"
     exon            2044..2268
                     /gene="DSC3"
                     /gene_synonym="CDHF3; DSC; DSC1; DSC2; DSC4; HT-CP"
                     /inference="alignment:Splign:1.39.8"
     exon            2269..2390
                     /gene="DSC3"
                     /gene_synonym="CDHF3; DSC; DSC1; DSC2; DSC4; HT-CP"
                     /inference="alignment:Splign:1.39.8"
     exon            2391..2648
                     /gene="DSC3"
                     /gene_synonym="CDHF3; DSC; DSC1; DSC2; DSC4; HT-CP"
                     /inference="alignment:Splign:1.39.8"
     STS             2534..2802
                     /gene="DSC3"
                     /gene_synonym="CDHF3; DSC; DSC1; DSC2; DSC4; HT-CP"
                     /standard_name="GDB:437227"
                     /db_xref="UniSTS:157243"
     STS             2535..2802
                     /gene="DSC3"
                     /gene_synonym="CDHF3; DSC; DSC1; DSC2; DSC4; HT-CP"
                     /db_xref="UniSTS:150383"
     variation       2612
                     /gene="DSC3"
                     /gene_synonym="CDHF3; DSC; DSC1; DSC2; DSC4; HT-CP"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:2228474"
     exon            2649..2691
                     /gene="DSC3"
                     /gene_synonym="CDHF3; DSC; DSC1; DSC2; DSC4; HT-CP"
                     /inference="alignment:Splign:1.39.8"
     exon            2692..6978
                     /gene="DSC3"
                     /gene_synonym="CDHF3; DSC; DSC1; DSC2; DSC4; HT-CP"
                     /inference="alignment:Splign:1.39.8"
     variation       3036
                     /gene="DSC3"
                     /gene_synonym="CDHF3; DSC; DSC1; DSC2; DSC4; HT-CP"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:948879"
     STS             3117..3366
                     /gene="DSC3"
                     /gene_synonym="CDHF3; DSC; DSC1; DSC2; DSC4; HT-CP"
                     /standard_name="RH39274"
                     /db_xref="UniSTS:85408"
     STS             4697..4881
                     /gene="DSC3"
                     /gene_synonym="CDHF3; DSC; DSC1; DSC2; DSC4; HT-CP"
                     /standard_name="RH47848"
                     /db_xref="UniSTS:89662"
     variation       4875..4877
                     /gene="DSC3"
                     /gene_synonym="CDHF3; DSC; DSC1; DSC2; DSC4; HT-CP"
                     /replace=""
                     /replace="c"
                     /replace="ccc"
                     /db_xref="dbSNP:66467743"
     STS             4922..5025
                     /gene="DSC3"
                     /gene_synonym="CDHF3; DSC; DSC1; DSC2; DSC4; HT-CP"
                     /standard_name="D11S2921"
                     /db_xref="UniSTS:152074"
     STS             4977..5079
                     /gene="DSC3"
                     /gene_synonym="CDHF3; DSC; DSC1; DSC2; DSC4; HT-CP"
                     /standard_name="D8S2278"
                     /db_xref="UniSTS:473906"
     STS             4985..5074
                     /gene="DSC3"
                     /gene_synonym="CDHF3; DSC; DSC1; DSC2; DSC4; HT-CP"
                     /standard_name="D8S2279"
                     /db_xref="UniSTS:473907"
     STS             5319..6010
                     /gene="DSC3"
                     /gene_synonym="CDHF3; DSC; DSC1; DSC2; DSC4; HT-CP"
                     /standard_name="DSC3_V8"
                     /db_xref="UniSTS:277171"
     variation       5934
                     /gene="DSC3"
                     /gene_synonym="CDHF3; DSC; DSC1; DSC2; DSC4; HT-CP"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:3204639"
     variation       5947
                     /gene="DSC3"
                     /gene_synonym="CDHF3; DSC; DSC1; DSC2; DSC4; HT-CP"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:2850323"
     variation       5967
                     /gene="DSC3"
                     /gene_synonym="CDHF3; DSC; DSC1; DSC2; DSC4; HT-CP"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1051487"
     polyA_signal    5979..5984
                     /gene="DSC3"
                     /gene_synonym="CDHF3; DSC; DSC1; DSC2; DSC4; HT-CP"
     polyA_site      5999
                     /gene="DSC3"
                     /gene_synonym="CDHF3; DSC; DSC1; DSC2; DSC4; HT-CP"
     variation       6379
                     /gene="DSC3"
                     /gene_synonym="CDHF3; DSC; DSC1; DSC2; DSC4; HT-CP"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:8765"
ORIGIN      
gaagttgctcccgggcaggcaagcctgagagaggccaaatacacttaaaaacaagcagcggcgagaaaagcacctcccgcgccctgcacctcggcaggtctcgctctcggcaccctcccggcgcccgcgttctcctggccctgcccggcatcccgatggccgccgctgggccccggcgctccgtgcgcggagccgtctgcctgcatctgctgctgaccctcgtgatcttcagtcgtgctggtgaagcctgcaaaaaggtgatacttaatgtaccttctaaactagaggcagacaaaataattggcagagttaatttggaagagtgcttcaggtctgcagacctcatccggtcaagtgatcctgatttcagagttctaaatgatgggtcagtgtacacagccagggctgttgcgctgtctgataagaaaagatcatttaccatatggctttctgacaaaaggaaacagacacagaaagaggttactgtgctgctagaacatcagaagaaggtatcgaagacaagacacactagagaaactgttctcaggcgtgccaagaggagatgggcacctattccttgctctatgcaagagaattccttgggccctttcccattgtttcttcaacaagttgaatctgatgcagcacagaactatactgtcttctactcaataagtggacgtggagttgataaagaacctttaaatttgttttatatagaaagagacactggaaatctattttgcactcggcctgtggatcgtgaagaatatgatgtttttgatttgattgcttatgcgtcaactgcagatggatattcagcagatctgcccctcccactacccatcagggtagaggatgaaaatgacaaccaccctgttttcacagaagcaatttataattttgaagttttggaaagtagtagacctggtactacagtgggggtggtttgtgccacagacagagatgaaccggacacaatgcatacgcgcctgaaatacagcattttgcagcagacaccaaggtcacctgggctcttttctgtgcatcccagcacaggcgtaatcaccacagtctctcattatttggacagagaggttgtagacaagtactcattgataatgaaagtacaagacatggatggccagttttttggattgataggcacatcaacttgtatcataacagtaacagattcaaatgataatgcacccactttcagacaaaatgcttatgaagcatttgtagaggaaaatgcattcaatgtggaaatcttacgaatacctatagaagataaggatttaattaacactgccaattggagagtcaattttaccattttaaagggaaatgaaaatggacatttcaaaatcagcacagacaaagaaactaatgaaggtgttctttctgttgtaaagccactgaattatgaagaaaaccgtcaagtgaacctggaaattggagtaaacaatgaagcgccatttgctagagatattcccagagtgacagccttgaacagagccttggttacagttcatgtgagggatctggatgaggggcctgaatgcactcctgcagcccaatatgtgcggattaaagaaaacttagcagtggggtcaaagatcaacggctataaggcatatgaccccgaaaatagaaatggcaatggtttaaggtacaaaaaattgcatgatcctaaaggttggatcaccattgatgaaatttcagggtcaatcataacttccaaaatcctggatagggaggttgaaactcccaaaaatgagttgtataatattacagtcctggcaatagacaaagatgatagatcatgtactggaacacttgctgtgaacattgaagatgtaaatgataatccaccagaaatacttcaagaatatgtagtcatttgcaaaccaaaaatggggtataccgacattttagctgttgatcctgatgaacctgtccatggagctccattttatttcagtttgcccaatacttctccagaaatcagtagactgtggagcctcaccaaagttaatgatacagctgcccgtctttcatatcagaaaaatgctggatttcaagaatataccattcctattactgtaaaagacagggccggccaagctgcaacaaaattattgagagttaatctgtgtgaatgtactcatccaactcagtgtcgtgcgacttcaaggagtacaggagtaatacttggaaaatgggcaatccttgcaatattactgggtatagcactgctcttttctgtattgctaactttagtatgtggagtttttggtgcaactaaagggaaacgttttcctgaagatttagcacagcaaaacttaattatatcaaacacagaagcacctggagacgatagagtgtgctctgccaatggatttatgacccaaactaccaacaactctagccaaggtttttgtggtactatgggatcaggaatgaaaaatggagggcaggaaaccattgaaatgatgaaaggaggaaaccagaccttggaatcctgccggggggctgggcatcatcataccctggactcctgcaggggaggacacacggaggtggacaactgcagatacacttactcggagtggcacagttttactcaaccccgtctcggtgaagaatccattagaggacacactggttaaaaattaaacataaaagaaattgcatcgatgtaatcagaatgaagaccgcatgccatcccaagattatgtcctcacttataactatgagggaagaggatctccagctggttctgtgggctgctgcagtgaaaagcaggaagaagatggccttgactttttaaataatttggaacccaaatttattacattagcagaagcatgcacaaagagataatgtcacagtgctacaattaggtctttgtcagacattctggaggtttccaaaaataatattgtaaagttcaatttcaacatgtatgtatatgatgatttttttctcaattttgaattatgctactcaccaatttatatttttaaagcaagttgttgcttatcttttccaaaaagtgaaaaatgttaaaacagacaactggtaaatctcaaactccagcactggaattaaggtctctaaagcatctgctcttttttttttttacggatattttagtaataaatatgctggataaatattagtccaacaatagctaagttatgctaatatcacattattatgtattcactttaagtgatagtttaaaaaataaacaagaaatattgagtatcactatgtgaagaaagttttggaaaagaaacaatgaagactgaattaaattaaaaatgttgcagctcataaagaattgggactcacccctactgcactaccaaattcatttgactttggaggcaaaatgtgttgaagtgccctatgaagtagcaattttctataggaatatagttggaaataaatgtgtgtgtgtatattattattaatcaatgcaatatttaaaatgaaatgagaacaaagaggaaaatggtaaaaacttgaaatgaggctggggtatagtttgtcctacaatagaaaaaagagagagcttcctaggcctgggctcttaaatgctgcattataactgagtctatgaggaaatagttcctgtccaatttgtgtaatttgtttaaaattgtaaataaattaaacttttctggtttctgtgggaaggaaatagggaatccaatggaacagtagctttgctttgcagtctgtttcaagatttctgcatccacaagttagtagcaaactggggaatactcgctgcagctggggttccctgctttttggtagcaagggtccagagatgaggtgtttttttcggggagctaataacaaaaacattttaaaacttacctttactgaagttaaatcctctattgctgtttctattctctcttatagtgaccaacatctttttaatttagatccaaataaccatgtcctcctagagtttagaggctagagggagctgaggggaggatcttactgaaagcaccctggggagattgattgtccttaaacctaagccccacaaacttgacacctgatcaggtctgggagctacaaaatttcatttttctcctcactgcccttcttctgagtggcattggcctgaatcaaggaaagccaggccttgtgggcccccttctttcggctttctgctaaagcaacacctccagcagagattcccttaagtgactccaggttttccaccatccttcagcgtgaattaatttttaatcagtttgctttctccagagaaattttaaaataatagaagaaatagaaattttgaatgtataaaagaaaaagatcaagttgtcattttagaacagagggaactttgggagaaagcagcccaagtaggttatttgtacagtcagagggcaacaggaagatgcaggccttcaagggcaaggagaggccacaaggaatatgggtgggagtaaaagcaacatcgtctgcttcatactttttcctaggcttggcactgccttttcctttctcaggccaatggcaactgccatttgagtccggtgagggatcagccaacctcttctctatggctcaccttatttggagtgagaaatcaaggagacagagctgactgcatgatgagtctgaaggcatttgcaggatgagcctgaactggttgtgcagaacaaacaaggcattcatgggaattgttgtattccttctgcagccctccttctgggcactaagaaggtctatgaattaaatgcctatctaaaattctgatttattcctacattttctgttttctaatttgaccctaaaatctatgtgttttagacttagactttttattgccccccccccccccttttttttttgagacggagtctcgctctgacgcacaggctggagtgcagtggctccgatctctgctcactgaaagctccgcctcccgggttcacgccattctcctgcctcagcctcctgagtagctgggactacaggcgcccaccaccacgcccggctaattttttgtatttttaatagagacggggtttcactgtgttagccaggatggtctcgatctcctgacctcgtgatccgcctgcctcggcctcccaaagtgctgggattacaggcatgacccaccgctcccggccttgttttccgtttaaagtcgtcttcttttaatgtaatcattttgaacatgtgtgaaagttgatcatacgaattggatcaatcttgaaatactcaaccaaaagacagtcgagaagccagggggagaaagaactcagggcacaaaatattggtctgagaatggaattctctgtaagcctagttgctgaaatttcctgctgtatccagaagccagttttatctaacggctactgaaacacccactgtgttttgctcactccctcactcaccgatcaaaacctgctacctccccaagactttactagtgccgataaactttctcaaagagcaaccagtatcacttccctgtttataaaacctctaaccatctctttgttctttgaacatgctgaaaaccacctggtctgcatgtatgcccgaatttgtaattcttttctctcaaatgaaaatttaattttagggattcatttctatattttcacatatgtagtattattatttccttatatgtgtaaggtgaaatttatggtatttgagtgtgcaagaaaatatatttttaaagctttcatttttcccccagtgaatgatttagaattttttatgtaaatatacagaatgttttttcttacttttataaggaagcagctgtctaaaatgcagtggggtttgttttgcaatgttttaaacagagttttagtattgctattaaaagaagttactttgcttttaaagaaacttggctgcttaaaataagcaaaaattggatgcgtaaagtaatatttacagatgtggggagatgtaataaaacaatattaacttggtttcttgtttttgctgtatttagagattaaataattctaagatgatcactttgcaaaattatgcttatggctggcatggaaatagaaataattatgtctttgttgtattaatggggaatattttggacaatgtttcattatcaaattgtcgacatcattaatatatattgtaatgttgggaagagatcactattttgaagcacagctttacagatgagtatctatgatacatatgtataataaattttgattgggtattaaaagtattagaaggtggttataattgcagagtattccatgaatagtacactgacacaggggttttactttgaggaccagtgtagtcaagggaaaacatgagttaaaaagaaaagcaggcgatattgcagtcttgattctgccacttacaggatagataacgcctgaactttaatgacaagatgatccaaccataaaggtgctctgtgcttcacagtgaatcttttccccatgcaggagtgtgctcccctacaaacgttaagactgatcatttcaaaaatctattagctatatcaaaagccttacattttaatataggttgaaccaaaatttcaattccagtaacttctattgtaaccattatttttgtgtatgtcttcaagaatgttcattggatttttgtttgtaatagtaaaataccggatacatttcacgtgtccttcagtattgatttggttgaatattgggtcataatggttgagaagcatggacactagagccagaatgcttggatatgaatcctggatctgtcacttacttctgtgtgacctttgaaaggctacttatttcctctcttagctttctcattaaaatcaatgaacaatgccagcctcatggggttgttgaatgattaaatgagttactatacctaaagtacatagaacactgcctgcacatagtaaaagaattataagtgtgaggtagttggtaaaattatgta
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:1825 -> Molecular function: GO:0005509 [calcium ion binding] evidence: IEA
            GeneID:1825 -> Molecular function: GO:0045295 [gamma-catenin binding] evidence: IPI
            GeneID:1825 -> Biological process: GO:0001701 [in utero embryonic development] evidence: IEA
            GeneID:1825 -> Biological process: GO:0007155 [cell adhesion] evidence: TAS
            GeneID:1825 -> Biological process: GO:0007156 [homophilic cell adhesion] evidence: IEA
            GeneID:1825 -> Biological process: GO:0050821 [protein stabilization] evidence: IDA
            GeneID:1825 -> Cellular component: GO:0005576 [extracellular region] evidence: IEA
            GeneID:1825 -> Cellular component: GO:0005737 [cytoplasm] evidence: IEA
            GeneID:1825 -> Cellular component: GO:0005886 [plasma membrane] evidence: IEA
            GeneID:1825 -> Cellular component: GO:0005911 [cell-cell junction] evidence: TAS
            GeneID:1825 -> Cellular component: GO:0016020 [membrane] evidence: TAS
            GeneID:1825 -> Cellular component: GO:0016021 [integral to membrane] evidence: IEA
            GeneID:1825 -> Cellular component: GO:0030057 [desmosome] evidence: IEA

by @meso_cacase at DBCLS
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