LOCUS       NM_024014                802 bp    mRNA    linear   PRI 17-APR-2013
DEFINITION  Homo sapiens homeobox A6 (HOXA6), mRNA.
ACCESSION   NM_024014
VERSION     NM_024014.3  GI:334724446
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 802)
  AUTHORS   Yerges,L.M., Klei,L., Cauley,J.A., Roeder,K., Kammerer,C.M.,
            Moffett,S.P., Ensrud,K.E., Nestlerode,C.S., Marshall,L.M.,
            Hoffman,A.R., Lewis,C., Lang,T.F., Barrett-Connor,E., Ferrell,R.E.,
            Orwoll,E.S. and Zmuda,J.M.
  CONSRTM   MrOS Research Group
  TITLE     High-density association study of 383 candidate genes for
            volumetric BMD at the femoral neck and lumbar spine among older men
  JOURNAL   J. Bone Miner. Res. 24 (12), 2039-2049 (2009)
   PUBMED   19453261
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   2  (bases 1 to 802)
  AUTHORS   Dickson,G.J., Kwasniewska,A., Mills,K.I., Lappin,T.R. and
            Thompson,A.
  TITLE     Hoxa6 potentiates short-term hemopoietic cell proliferation and
            extended self-renewal
  JOURNAL   Exp. Hematol. 37 (3), 322-333 (2009)
   PUBMED   19157684
  REMARK    GeneRIF: Enforced overexpression of HOXA6 or HOXA9 in FDCP-Mix
            resulted in increased proliferation and colony formation but had
            negligible effect on differentiation in early multipotential and
            later committed precursor cells
REFERENCE   3  (bases 1 to 802)
  AUTHORS   Lamesch,P., Li,N., Milstein,S., Fan,C., Hao,T., Szabo,G., Hu,Z.,
            Venkatesan,K., Bethel,G., Martin,P., Rogers,J., Lawlor,S.,
            McLaren,S., Dricot,A., Borick,H., Cusick,M.E., Vandenhaute,J.,
            Dunham,I., Hill,D.E. and Vidal,M.
  TITLE     hORFeome v3.1: a resource of human open reading frames representing
            over 10,000 human genes
  JOURNAL   Genomics 89 (3), 307-315 (2007)
   PUBMED   17207965
REFERENCE   4  (bases 1 to 802)
  AUTHORS   Kosaki,K., Kosaki,R., Suzuki,T., Yoshihashi,H., Takahashi,T.,
            Sasaki,K., Tomita,M., McGinnis,W. and Matsuo,N.
  TITLE     Complete mutation analysis panel of the 39 human HOX genes
  JOURNAL   Teratology 65 (2), 50-62 (2002)
   PUBMED   11857506
REFERENCE   5  (bases 1 to 802)
  AUTHORS   Walters,J.R., Howard,A., Rumble,H.E., Prathalingam,S.R.,
            Shaw-Smith,C.J. and Legon,S.
  TITLE     Differences in expression of homeobox transcription factors in
            proximal and distal human small intestine
  JOURNAL   Gastroenterology 113 (2), 472-477 (1997)
   PUBMED   9247466
REFERENCE   6  (bases 1 to 802)
  AUTHORS   Apiou,F., Flagiello,D., Cillo,C., Malfoy,B., Poupon,M.F. and
            Dutrillaux,B.
  TITLE     Fine mapping of human HOX gene clusters
  JOURNAL   Cytogenet. Cell Genet. 73 (1-2), 114-115 (1996)
   PUBMED   8646877
REFERENCE   7  (bases 1 to 802)
  AUTHORS   Scott,M.P.
  TITLE     Vertebrate homeobox gene nomenclature
  JOURNAL   Cell 71 (4), 551-553 (1992)
   PUBMED   1358459
REFERENCE   8  (bases 1 to 802)
  AUTHORS   McAlpine,P.J. and Shows,T.B.
  TITLE     Nomenclature for human homeobox genes
  JOURNAL   Genomics 7 (3), 460 (1990)
   PUBMED   1973146
REFERENCE   9  (bases 1 to 802)
  AUTHORS   Boncinelli,E., Acampora,D., Pannese,M., D'Esposito,M., Somma,R.,
            Gaudino,G., Stornaiuolo,A., Cafiero,M., Faiella,A. and Simeone,A.
  TITLE     Organization of human class I homeobox genes
  JOURNAL   Genome 31 (2), 745-756 (1989)
   PUBMED   2576652
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC104915.1.
            On Jun 3, 2011 this sequence version replaced gi:24797131.
            
            Summary: In vertebrates, the genes encoding the class of
            transcription factors called homeobox genes are found in clusters
            named A, B, C, and D on four separate chromosomes. Expression of
            these proteins is spatially and temporally regulated during
            embryonic development. This gene is part of the A cluster on
            chromosome 7 and encodes a DNA-binding transcription factor which
            may regulate gene expression, morphogenesis, and differentiation.
            [provided by RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC104915.1, BC069497.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           ERS025081, ERS025084 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-802               BC104915.1         1-802
FEATURES             Location/Qualifiers
     source          1..802
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p15.2"
     gene            1..802
                     /gene="HOXA6"
                     /gene_synonym="HOX1; HOX1.2; HOX1B"
                     /note="homeobox A6"
                     /db_xref="GeneID:3203"
                     /db_xref="HGNC:5107"
                     /db_xref="HPRD:00839"
                     /db_xref="MIM:142951"
     STS             1..802
                     /gene="HOXA6"
                     /gene_synonym="HOX1; HOX1.2; HOX1B"
                     /db_xref="UniSTS:485837"
     exon            1..467
                     /gene="HOXA6"
                     /gene_synonym="HOX1; HOX1.2; HOX1B"
                     /inference="alignment:Splign:1.39.8"
     STS             26..777
                     /gene="HOXA6"
                     /gene_synonym="HOX1; HOX1.2; HOX1B"
                     /db_xref="UniSTS:480721"
     CDS             26..727
                     /gene="HOXA6"
                     /gene_synonym="HOX1; HOX1.2; HOX1B"
                     /note="homeo box A6; homeo box 1B; homeobox protein HOXA6;
                     homeobox protein Hox-1B"
                     /codon_start=1
                     /product="homeobox protein Hox-A6"
                     /protein_id="NP_076919.1"
                     /db_xref="GI:13489077"
                     /db_xref="CCDS:CCDS5407.1"
                     /db_xref="GeneID:3203"
                     /db_xref="HGNC:5107"
                     /db_xref="HPRD:00839"
                     /db_xref="MIM:142951"
                     /translation="

MSSYFVNPTFPGSLPSGQDSFLGQLPLYQAGYDALRPFPASYGASSLPDKTYTSPCFYQQSNSVLACNRASYEYGASCFYSDKDLSGASPSGSGKQRGPGDYLHFSPEQQYKPDSSSGQGKALHDEGADRKYTSPVYPWMQRMNSCAGAVYGSHGRRGRQTYTRYQTLELEKEFHFNRYLTRRRRIEIANALCLTERQIKIWFQNRRMKWKKENKLINSTQPSGEDSEAKAGE

"
     misc_feature    431..448
                     /gene="HOXA6"
                     /gene_synonym="HOX1; HOX1.2; HOX1B"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P31267.2);
                     Region: Antp-type hexapeptide"
     misc_feature    <530..667
                     /gene="HOXA6"
                     /gene_synonym="HOX1; HOX1.2; HOX1B"
                     /note="Homeodomain;  DNA binding domains involved in the
                     transcriptional regulation of key eukaryotic developmental
                     processes; may bind to DNA as monomers or as homo- and/or
                     heterodimers, in a sequence-specific manner; Region:
                     homeodomain; cd00086"
                     /db_xref="CDD:28970"
     misc_feature    order(560..562,578..580,617..619,623..628,635..640,
                     644..652,656..661)
                     /gene="HOXA6"
                     /gene_synonym="HOX1; HOX1.2; HOX1B"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:28970"
     misc_feature    order(626..628,635..640,647..649)
                     /gene="HOXA6"
                     /gene_synonym="HOX1; HOX1.2; HOX1B"
                     /note="specific DNA base contacts [nucleotide binding];
                     other site"
                     /db_xref="CDD:28970"
     variation       complement(27)
                     /gene="HOXA6"
                     /gene_synonym="HOX1; HOX1.2; HOX1B"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:372988125"
     STS             33..100
                     /gene="HOXA6"
                     /gene_synonym="HOX1; HOX1.2; HOX1B"
                     /standard_name="Hoxa6"
                     /db_xref="UniSTS:536644"
     variation       complement(50)
                     /gene="HOXA6"
                     /gene_synonym="HOX1; HOX1.2; HOX1B"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:375214907"
     variation       complement(55)
                     /gene="HOXA6"
                     /gene_synonym="HOX1; HOX1.2; HOX1B"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:370785785"
     variation       complement(56)
                     /gene="HOXA6"
                     /gene_synonym="HOX1; HOX1.2; HOX1B"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:371909980"
     variation       complement(73)
                     /gene="HOXA6"
                     /gene_synonym="HOX1; HOX1.2; HOX1B"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:370341498"
     variation       complement(94)
                     /gene="HOXA6"
                     /gene_synonym="HOX1; HOX1.2; HOX1B"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:149022222"
     STS             105..349
                     /gene="HOXA6"
                     /gene_synonym="HOX1; HOX1.2; HOX1B"
                     /standard_name="REN100540"
                     /db_xref="UniSTS:425337"
     variation       complement(126)
                     /gene="HOXA6"
                     /gene_synonym="HOX1; HOX1.2; HOX1B"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:376057404"
     variation       complement(128)
                     /gene="HOXA6"
                     /gene_synonym="HOX1; HOX1.2; HOX1B"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:186744061"
     variation       complement(151)
                     /gene="HOXA6"
                     /gene_synonym="HOX1; HOX1.2; HOX1B"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:373980441"
     variation       complement(231)
                     /gene="HOXA6"
                     /gene_synonym="HOX1; HOX1.2; HOX1B"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:368790713"
     variation       complement(274)
                     /gene="HOXA6"
                     /gene_synonym="HOX1; HOX1.2; HOX1B"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:144914171"
     variation       complement(293)
                     /gene="HOXA6"
                     /gene_synonym="HOX1; HOX1.2; HOX1B"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:145294674"
     variation       complement(307)
                     /gene="HOXA6"
                     /gene_synonym="HOX1; HOX1.2; HOX1B"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:369375493"
     variation       complement(365)
                     /gene="HOXA6"
                     /gene_synonym="HOX1; HOX1.2; HOX1B"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:62454418"
     variation       complement(412)
                     /gene="HOXA6"
                     /gene_synonym="HOX1; HOX1.2; HOX1B"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:200483396"
     variation       complement(426)
                     /gene="HOXA6"
                     /gene_synonym="HOX1; HOX1.2; HOX1B"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:139795399"
     variation       complement(427)
                     /gene="HOXA6"
                     /gene_synonym="HOX1; HOX1.2; HOX1B"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:147820248"
     variation       complement(439)
                     /gene="HOXA6"
                     /gene_synonym="HOX1; HOX1.2; HOX1B"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:144375853"
     variation       complement(450)
                     /gene="HOXA6"
                     /gene_synonym="HOX1; HOX1.2; HOX1B"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:139581191"
     variation       complement(451)
                     /gene="HOXA6"
                     /gene_synonym="HOX1; HOX1.2; HOX1B"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:17472042"
     exon            468..802
                     /gene="HOXA6"
                     /gene_synonym="HOX1; HOX1.2; HOX1B"
                     /inference="alignment:Splign:1.39.8"
     variation       complement(484)
                     /gene="HOXA6"
                     /gene_synonym="HOX1; HOX1.2; HOX1B"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:17500863"
     variation       complement(515)
                     /gene="HOXA6"
                     /gene_synonym="HOX1; HOX1.2; HOX1B"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:376435844"
     STS             517..772
                     /gene="HOXA6"
                     /gene_synonym="HOX1; HOX1.2; HOX1B"
                     /standard_name="REN100532"
                     /db_xref="UniSTS:425329"
     variation       complement(531)
                     /gene="HOXA6"
                     /gene_synonym="HOX1; HOX1.2; HOX1B"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:202074180"
     variation       complement(584)
                     /gene="HOXA6"
                     /gene_synonym="HOX1; HOX1.2; HOX1B"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:373414972"
     variation       complement(593)
                     /gene="HOXA6"
                     /gene_synonym="HOX1; HOX1.2; HOX1B"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:141474913"
     variation       complement(614)
                     /gene="HOXA6"
                     /gene_synonym="HOX1; HOX1.2; HOX1B"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:369149965"
     variation       complement(637)
                     /gene="HOXA6"
                     /gene_synonym="HOX1; HOX1.2; HOX1B"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:74417774"
     variation       complement(644)
                     /gene="HOXA6"
                     /gene_synonym="HOX1; HOX1.2; HOX1B"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:188748627"
     variation       complement(675)
                     /gene="HOXA6"
                     /gene_synonym="HOX1; HOX1.2; HOX1B"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:375876584"
     variation       complement(681)
                     /gene="HOXA6"
                     /gene_synonym="HOX1; HOX1.2; HOX1B"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:370024061"
     variation       complement(719)
                     /gene="HOXA6"
                     /gene_synonym="HOX1; HOX1.2; HOX1B"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:377212926"
     variation       complement(724)
                     /gene="HOXA6"
                     /gene_synonym="HOX1; HOX1.2; HOX1B"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:62454417"
ORIGIN      

cacagtcctgcagaggggcgcgcaaatgagttcctattttgtgaatcccactttccccgggagccttcccagcggccaggactccttcttgggccagctgcccctctaccaggctggctatgacgcgctgaggcccttcccggcctcgtacggggcgtcgagtctcccggacaagacgtacacctcaccttgtttctaccaacagtccaactcggtcctggcctgcaaccgggcgtcctacgagtacggggcctcgtgtttctattctgataaggacctcagtggcgcctcgccctcgggcagtggcaagcagaggggccccggggactacctgcacttttctcccgagcagcagtacaaacccgacagcagcagcgggcagggcaaagcactccatgacgaaggcgccgaccggaagtacacgagcccggtttacccttggatgcagcggatgaactcctgcgcgggtgctgtgtatgggagccatgggcgccgaggccgccagacctacacgcgctaccagacactggagctggagaaggagttccacttcaaccgctacctgacacggcgccgccgcatcgagatcgccaacgcgctctgcctcaccgagcgccagatcaagatctggttccagaaccgccgcatgaagtggaaaaaggaaaacaagctcatcaattccacgcagcccagcggggaggactcagaggcaaaggcgggcgagtagatgcctgggcagggaccaggccagcgctgcaacctccttcggctttgcccccttgccctcgcctgttccccaact

//

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:3203 -> Molecular function: GO:0003700 [sequence-specific DNA binding transcription factor activity] evidence: IEA
            GeneID:3203 -> Molecular function: GO:0043565 [sequence-specific DNA binding] evidence: IEA
            GeneID:3203 -> Biological process: GO:0006351 [transcription, DNA-dependent] evidence: IEA
            GeneID:3203 -> Biological process: GO:0009952 [anterior/posterior pattern specification] evidence: IEA
            GeneID:3203 -> Biological process: GO:0048704 [embryonic skeletal system morphogenesis] evidence: IEA
            GeneID:3203 -> Cellular component: GO:0005634 [nucleus] evidence: IEA