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2024-03-29 17:17:52, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_022899               3629 bp    mRNA    linear   PRI 17-APR-2013
DEFINITION  Homo sapiens ARP8 actin-related protein 8 homolog (yeast) (ACTR8),
            mRNA.
ACCESSION   NM_022899
VERSION     NM_022899.4  GI:296010797
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3629)
  AUTHORS   Gerhold,C.B., Winkler,D.D., Lakomek,K., Seifert,F.U., Fenn,S.,
            Kessler,B., Witte,G., Luger,K. and Hopfner,K.P.
  TITLE     Structure of Actin-related protein 8 and its contribution to
            nucleosome binding
  JOURNAL   Nucleic Acids Res. 40 (21), 11036-11046 (2012)
   PUBMED   22977180
  REMARK    GeneRIF: Binding studies reveal that Arp8 and the
            Arp8-Arp4-actin-HSA sub-complex of INO80 strongly prefer
            nucleosomes and H3-H4 tetramers over H2A-H2B dimers, suggesting
            that Arp8 functions as a nucleosome recognition module.
REFERENCE   2  (bases 1 to 3629)
  AUTHORS   Casabonne,D., Reina,O., Benavente,Y., Becker,N., Maynadie,M.,
            Foretova,L., Cocco,P., Gonzalez-Neira,A., Nieters,A., Boffetta,P.,
            Middeldorp,J.M. and de Sanjose,S.
  TITLE     Single nucleotide polymorphisms of matrix metalloproteinase 9
            (MMP9) and tumor protein 73 (TP73) interact with Epstein-Barr virus
            in chronic lymphocytic leukemia: results from the European
            case-control study EpiLymph
  JOURNAL   Haematologica 96 (2), 323-327 (2011)
   PUBMED   21048031
  REMARK    GeneRIF: Observational study of gene-disease association and
            gene-environment interaction. (HuGE Navigator)
REFERENCE   3  (bases 1 to 3629)
  AUTHORS   Kashiwaba,S., Kitahashi,K., Watanabe,T., Onoda,F., Ohtsu,M. and
            Murakami,Y.
  TITLE     The mammalian INO80 complex is recruited to DNA damage sites in an
            ARP8 dependent manner
  JOURNAL   Biochem. Biophys. Res. Commun. 402 (4), 619-625 (2010)
   PUBMED   20971067
  REMARK    GeneRIF: These results suggest that ARP8 is required for the
            recruitment of the mammalian INO80 complex to the laser-induced DNA
            damage sites.
REFERENCE   4  (bases 1 to 3629)
  AUTHORS   Yao,T., Song,L., Jin,J., Cai,Y., Takahashi,H., Swanson,S.K.,
            Washburn,M.P., Florens,L., Conaway,R.C., Cohen,R.E. and
            Conaway,J.W.
  TITLE     Distinct modes of regulation of the Uch37 deubiquitinating enzyme
            in the proteasome and in the Ino80 chromatin-remodeling complex
  JOURNAL   Mol. Cell 31 (6), 909-917 (2008)
   PUBMED   18922472
REFERENCE   5  (bases 1 to 3629)
  AUTHORS   Aoyama,N., Oka,A., Kitayama,K., Kurumizaka,H. and Harata,M.
  TITLE     The actin-related protein hArp8 accumulates on the mitotic
            chromosomes and functions in chromosome alignment
  JOURNAL   Exp. Cell Res. 314 (4), 859-868 (2008)
   PUBMED   18163988
  REMARK    GeneRIF: Expression of truncated hArp8 proteins and depletion of
            endogenous hArp8 by RNA interference caused misalignment of mitotic
            chromosomes, suggesting that chromosome-associated hArp8 has a role
            in chromosome behavior.
REFERENCE   6  (bases 1 to 3629)
  AUTHORS   Wu,S., Shi,Y., Mulligan,P., Gay,F., Landry,J., Liu,H., Lu,J.,
            Qi,H.H., Wang,W., Nickoloff,J.A., Wu,C. and Shi,Y.
  TITLE     A YY1-INO80 complex regulates genomic stability through homologous
            recombination-based repair
  JOURNAL   Nat. Struct. Mol. Biol. 14 (12), 1165-1172 (2007)
   PUBMED   18026119
REFERENCE   7  (bases 1 to 3629)
  AUTHORS   Jin,J., Cai,Y., Yao,T., Gottschalk,A.J., Florens,L., Swanson,S.K.,
            Gutierrez,J.L., Coleman,M.K., Workman,J.L., Mushegian,A.,
            Washburn,M.P., Conaway,R.C. and Conaway,J.W.
  TITLE     A mammalian chromatin remodeling complex with similarities to the
            yeast INO80 complex
  JOURNAL   J. Biol. Chem. 280 (50), 41207-41212 (2005)
   PUBMED   16230350
REFERENCE   8  (bases 1 to 3629)
  AUTHORS   Hassel,S., Eichner,A., Yakymovych,M., Hellman,U., Knaus,P. and
            Souchelnytskyi,S.
  TITLE     Proteins associated with type II bone morphogenetic protein
            receptor (BMPR-II) and identified by two-dimensional gel
            electrophoresis and mass spectrometry
  JOURNAL   Proteomics 4 (5), 1346-1358 (2004)
   PUBMED   15188402
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA453867.1, AK022996.1 and AC012467.9.
            On May 13, 2010 this sequence version replaced gi:39812114.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK022996.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           ERS025081, ERS025082 [ECO:0000350]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-50                DA453867.1         1-50
            51-1887             AK022996.1         1-1837
            1888-3629           AC012467.9         47289-49030
FEATURES             Location/Qualifiers
     source          1..3629
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p21.31"
     gene            1..3629
                     /gene="ACTR8"
                     /gene_synonym="ARP8; hArp8; INO80N"
                     /note="ARP8 actin-related protein 8 homolog (yeast)"
                     /db_xref="GeneID:93973"
                     /db_xref="HGNC:14672"
                     /db_xref="HPRD:09792"
     exon            1..224
                     /gene="ACTR8"
                     /gene_synonym="ARP8; hArp8; INO80N"
                     /inference="alignment:Splign:1.39.8"
     CDS             102..1976
                     /gene="ACTR8"
                     /gene_synonym="ARP8; hArp8; INO80N"
                     /note="INO80 complex subunit N"
                     /codon_start=1
                     /product="actin-related protein 8"
                     /protein_id="NP_075050.3"
                     /db_xref="GI:39812115"
                     /db_xref="CCDS:CCDS2875.1"
                     /db_xref="GeneID:93973"
                     /db_xref="HGNC:14672"
                     /db_xref="HPRD:09792"
                     /translation="
MTQAEKGDTENGKEKGGEKEKEQRGVKRPIVPALVPESLQEQIQSNFIIVIHPGSTTLRIGRATDTLPASIPHVIARRHKQQGQPLYKDSWLLREGLNKPESNEQRQNGLKMVDQAIWSKKMSNGTRRIPVSPEQARSYNKQMRPAILDHCSGNKWTNTSHHPEYLVGEEALYVNPLDCYNIHWPIRRGQLNIHPGPGGSLTAVLADIEVIWSHAIQKYLEIPLKDLKYYRCILLIPDIYNKQHVKELVNMILMKMGFSGIVVHQESVCATYGSGLSSTCIVDVGDQKTSVCCVEDGVSHRNTRLCLAYGGSDVSRCFYWLMQRAGFPYRECQLTNKMDCLLLQHLKETFCHLDQDISGLQDHEFQIRHPDSPALLYQFRLGDEKLQAPMALFYPATFGIVGQKMTTLQHRSQGDPEDPHDEHYLLATQSKQEQSAKATADRKSASKPIGFEGDLRGQSSDLPERLHSQEVDLGSAQGDGLMAGNDSEEALTALMSRKTAISLFEGKALGLDKAILHSIDCCSSDDTKKKMYSSILVVGGGLMFHKAQEFLQHRILNKMPPSFRRIIENVDVITRPKDMDPRLIAWKGGAVLACLDTTQELWIYQREWQRFGVRMLRERAAFVW
"
     misc_feature    495..497
                     /gene="ACTR8"
                     /gene_synonym="ARP8; hArp8; INO80N"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (Q9H981.2); phosphorylation site"
     misc_feature    495..497
                     /gene="ACTR8"
                     /gene_synonym="ARP8; hArp8; INO80N"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     misc_feature    600..1958
                     /gene="ACTR8"
                     /gene_synonym="ARP8; hArp8; INO80N"
                     /note="Actin and related proteins [Cytoskeleton]; Region:
                     COG5277"
                     /db_xref="CDD:34874"
     misc_feature    678..>992
                     /gene="ACTR8"
                     /gene_synonym="ARP8; hArp8; INO80N"
                     /note="Nucleotide-Binding Domain of the sugar
                     kinase/HSP70/actin superfamily; Region:
                     NBD_sugar-kinase_HSP70_actin; cd00012"
                     /db_xref="CDD:212657"
     misc_feature    1335..1337
                     /gene="ACTR8"
                     /gene_synonym="ARP8; hArp8; INO80N"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (Q9H981.2); phosphorylation site"
     misc_feature    <1626..1961
                     /gene="ACTR8"
                     /gene_synonym="ARP8; hArp8; INO80N"
                     /note="Nucleotide-Binding Domain of the sugar
                     kinase/HSP70/actin superfamily; Region:
                     NBD_sugar-kinase_HSP70_actin; cl17037"
                     /db_xref="CDD:214262"
     exon            225..395
                     /gene="ACTR8"
                     /gene_synonym="ARP8; hArp8; INO80N"
                     /inference="alignment:Splign:1.39.8"
     exon            396..506
                     /gene="ACTR8"
                     /gene_synonym="ARP8; hArp8; INO80N"
                     /inference="alignment:Splign:1.39.8"
     exon            507..611
                     /gene="ACTR8"
                     /gene_synonym="ARP8; hArp8; INO80N"
                     /inference="alignment:Splign:1.39.8"
     exon            612..785
                     /gene="ACTR8"
                     /gene_synonym="ARP8; hArp8; INO80N"
                     /inference="alignment:Splign:1.39.8"
     exon            786..879
                     /gene="ACTR8"
                     /gene_synonym="ARP8; hArp8; INO80N"
                     /inference="alignment:Splign:1.39.8"
     exon            880..1012
                     /gene="ACTR8"
                     /gene_synonym="ARP8; hArp8; INO80N"
                     /inference="alignment:Splign:1.39.8"
     exon            1013..1166
                     /gene="ACTR8"
                     /gene_synonym="ARP8; hArp8; INO80N"
                     /inference="alignment:Splign:1.39.8"
     exon            1167..1262
                     /gene="ACTR8"
                     /gene_synonym="ARP8; hArp8; INO80N"
                     /inference="alignment:Splign:1.39.8"
     exon            1263..1403
                     /gene="ACTR8"
                     /gene_synonym="ARP8; hArp8; INO80N"
                     /inference="alignment:Splign:1.39.8"
     exon            1404..1668
                     /gene="ACTR8"
                     /gene_synonym="ARP8; hArp8; INO80N"
                     /inference="alignment:Splign:1.39.8"
     variation       1619
                     /gene="ACTR8"
                     /gene_synonym="ARP8; hArp8; INO80N"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1046677"
     exon            1669..1832
                     /gene="ACTR8"
                     /gene_synonym="ARP8; hArp8; INO80N"
                     /inference="alignment:Splign:1.39.8"
     exon            1833..3629
                     /gene="ACTR8"
                     /gene_synonym="ARP8; hArp8; INO80N"
                     /inference="alignment:Splign:1.39.8"
     variation       1997
                     /gene="ACTR8"
                     /gene_synonym="ARP8; hArp8; INO80N"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1046686"
     variation       2498
                     /gene="ACTR8"
                     /gene_synonym="ARP8; hArp8; INO80N"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:201451819"
     STS             2535..2636
                     /gene="ACTR8"
                     /gene_synonym="ARP8; hArp8; INO80N"
                     /standard_name="WI-14906"
                     /db_xref="UniSTS:6233"
     variation       3111
                     /gene="ACTR8"
                     /gene_synonym="ARP8; hArp8; INO80N"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:2241806"
     STS             3177..3318
                     /gene="ACTR8"
                     /gene_synonym="ARP8; hArp8; INO80N"
                     /standard_name="RH99050"
                     /db_xref="UniSTS:88303"
ORIGIN      
gactgtgggcagccggccgtgcgcctgcgcggtggcccttccatcccggcagtcgtggctgcagcgctgaggcgagaggttggtgggtgtctccggccataatgacccaggctgagaagggtgatacggagaacggaaaggagaagggcggcgagaaggagaaggagcagcgcggcgtgaagcggcccatcgtgcccgcgctggtgccggagtcgctgcaagagcaaatccagagcaacttcatcattgtcatacatccaggttcaacaactttaaggattggtcgagccacagacactcttcctgccagcattcctcacgtcattgcccgaagacacaaacaacaagggcagcccctatacaaggacagttggctcctaagggagggactaaataaaccagaaagtaatgaacaaagacaaaatggccttaaaatggtggatcaagcaatatggtctaaaaagatgtccaatggtacaagacgcattcctgtgtcccctgaacaggcacgctcctacaataagcagatgcgacctgcaattttagatcactgttcgggaaataagtggacaaacacatctcatcaccctgagtatttagtaggagaagaggccttgtatgttaatccactggactgttacaatattcactggcctatcagaagaggtcagttaaatattcacccaggccctgggggctctcttacagctgttctggcagatattgaagtaatatggtctcatgcgatacaaaaatacttggaaatcccactgaaagatttaaagtattatagatgtatcttgttaattcctgatatctataataagcagcatgtgaaagaactagtgaatatgatactaatgaagatgggtttttcagggattgtggtccatcaggagtctgtgtgtgccacctatggaagtggcttaagcagcacgtgtattgtagacgttggggaccagaagacaagtgtatgctgtgtggaggatggggtgtctcatcggaatactcggctttgtctggcatacggaggatctgatgtgtcaagatgtttttactggctaatgcagcgagctgggttcccttacagagaatgccagttaacaaataaaatggattgtcttcttctgcaacaccttaaagaaactttttgtcatttagatcaggacatctctgggcttcaggaccatgagtttcagattcgacatcctgattctcctgccctgctttaccagtttcgattaggagatgaaaaactgcaggctccaatggctttgttttaccccgcaacttttggaatcgttggacagaaaatgacgactttgcagcacagatctcagggcgatcctgaggatcctcacgatgaacattacctgctggccacacagagcaaacaagaacagtctgcaaaagctactgctgaccgaaagtctgcatccaaacctattggatttgaaggggatcttcgtggccagtcctctgatcttccagaaagactccattcccaggaggtagatttggggtctgcacagggagatggcctgatggccggcaacgattccgaggaggccctcactgcactgatgtccaggaagactgccatctcgctgtttgaaggaaaagccctgggcctggataaagccatcctccatagcatagactgctgttcatctgacgacaccaaaaagaagatgtacagctccatcctagtggtgggaggtggtttgatgtttcataaagctcaagaatttctgcagcacagaattctcaacaaaatgccaccatccttcaggcgaattattgaaaatgtggatgtgatcacaaggcctaaggacatggacccccggctgattgcatggaaaggaggggcagtgttggcttgtttggatacaacacaggaactgtggatttatcagcgagagtggcagcgctttggtgtccgcatgttacgagagcgggctgcgtttgtgtggtgaatggggaggaaatgtcactgccgaagaccaaaaacaagcttcttggtataaaagactcttacagaatatgtgtattgtaatttattgatctggatgcttaagtgtcatggacagtaaatgaatttgaactttatgttgaggacatgacattggtttgaaaatataaactgcttttgagcagtttagtcagggcatttgagaataaataggaactttctcttcagttgtaaactctcttgccctctctcagggtctcataaactccccagtgatgtaaacgttgctattgaaggttctcatgtggtgaagcccttcatttaagttggcttgaatctcatcagcaggcagcctcatgcaaccatgagggatagtatgtgacgagggagaactgtccactcatgccattttctctcttgtctagtatttcattaggatctaaagttgtctgagttaaatgcacttatgtgactcatgtgtcctcttagaatcccaaatagggggaaaaagttttggtggtttttgttttttttttcattttctgttggattacagaaaaagaatgggacccattcaggtctcgatttccaaaggtaaagatggaaggctgggcagactggcttttgttacctgacatgccgtagggtgagcttagaggaagaaagaaaacaatttttatttggccaaaacagaacaaatgctgaaaaggaaatcttgtttttttcctaaagccaaatagaaatgatttgggtataatttaagagtccttgtgttgtacagatatggtgactgatgtagttattaatactaccaacttagtcatcaagcctcaattttcctttacctgaaggattaagtgaaagcttttggagttcatgatgttcagtatgatcagttaaccttaacctctgagcatcctgaagcaaaatctaaataatgcagctattaccactggtggtccaggctctggtgaagccctctgagcccaggaggaagagaaagcattgtccagaggtaggaacacagtctgggagcccagagctctgggaggagtgggaaaatgctgcttcctgctgcttgcttctaggcacctgcttccgccatctcacttaccatggctagagatgggggtgagactggggaaggacaaaagcagggaacagataagtgatggaaatcagaagggaatatagaaagaactctggatgtggagaaatgccggtacctgagcattttgtatcaatgggagtaccctctgtaactgctcagtaggttacaaatgaagagtccaccagtattagaaacaatttaaacttgccagtaccaactgggatgtgtgccttcaatttgaaaattgtatgttttattttttaaatttgttaacagcattaatttatagagtattgatgtcatttatgtttctgaggtgtttcaacacaattttggatcagctgcctgtttgcaaaaacataatatatttctgttaaacagttcttcacctaacagcatattgctcttataactggtagagctgtttcaaaggaagttggtttctggtccaagttttgacctaaaccatgtccatcttctattaccagcacttacaagcactgtgaaaactgatcatgacaaataagtaaaatttgctacattaaa
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:93973 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
            GeneID:93973 -> Molecular function: GO:0005524 [ATP binding] evidence: IEA
            GeneID:93973 -> Biological process: GO:0006281 [DNA repair] evidence: IEA
            GeneID:93973 -> Biological process: GO:0006310 [DNA recombination] evidence: IEA
            GeneID:93973 -> Biological process: GO:0006338 [chromatin remodeling] evidence: IEA
            GeneID:93973 -> Biological process: GO:0006351 [transcription, DNA-dependent] evidence: IEA
            GeneID:93973 -> Biological process: GO:0006355 [regulation of transcription, DNA-dependent] evidence: IEA
            GeneID:93973 -> Biological process: GO:0007067 [mitosis] evidence: IEA
            GeneID:93973 -> Biological process: GO:0051301 [cell division] evidence: IEA
            GeneID:93973 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
            GeneID:93973 -> Cellular component: GO:0031011 [Ino80 complex] evidence: IDA

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