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2024-04-23 22:07:04, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_022117 2833 bp mRNA linear PRI 17-APR-2013
DEFINITION Homo sapiens TSPY-like 2 (TSPYL2), mRNA.
ACCESSION NM_022117 XM_939609 XM_944226 XM_944229 XM_944231
VERSION NM_022117.3 GI:259906401
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2833)
AUTHORS Drakou,C.E., Malekkou,A., Hayes,J.M., Lederer,C.W., Leonidas,D.D.,
Oikonomakos,N.G., Lamond,A.I., Santama,N. and Zographos,S.E.
TITLE hCINAP is an atypical mammalian nuclear adenylate kinase with an
ATPase motif: structural and functional studies
JOURNAL Proteins 80 (1), 206-220 (2012)
PUBMED 22038794
REMARK GeneRIF: hCINAP may not simply regulate nucleotide homeostasis, but
may have broader functionality, including control of Cajal body
assembly and disassembly
REFERENCE 2 (bases 1 to 2833)
AUTHORS Lau,Y.F., Li,Y. and Kido,T.
TITLE Role of the Y-located putative gonadoblastoma gene in human
spermatogenesis
JOURNAL Syst Biol Reprod Med 57 (1-2), 27-34 (2011)
PUBMED 21204751
REMARK GeneRIF: TSPX is principally expressed in Sertoli cells in the
human testis.
REFERENCE 3 (bases 1 to 2833)
AUTHORS Zhang,J., Zhang,F. and Zheng,X.
TITLE Depletion of hCINAP by RNA interference causes defects in Cajal
body formation, histone transcription, and cell viability
JOURNAL Cell. Mol. Life Sci. 67 (11), 1907-1918 (2010)
PUBMED 20186459
REMARK GeneRIF: knockdown of CINAP expression results in marked reduction
of histone transcription, lower levels of U small nuclear RNAs (U1,
U2, U4, and U5), and a loss of cell viability
REFERENCE 4 (bases 1 to 2833)
AUTHORS Kido,T. and Lau,Y.F.
TITLE The human Y-encoded testis-specific protein interacts functionally
with eukaryotic translation elongation factor eEF1A, a putative
oncoprotein
JOURNAL Int. J. Cancer 123 (7), 1573-1585 (2008)
PUBMED 18649364
REFERENCE 5 (bases 1 to 2833)
AUTHORS Kandalaft,L.E., Zudaire,E., Portal-Nunez,S., Cuttitta,F. and
Jakowlew,S.B.
TITLE Differentially expressed nucleolar transforming growth factor-beta1
target (DENTT) exhibits an inhibitory role on tumorigenesis
JOURNAL Carcinogenesis 29 (6), 1282-1289 (2008)
PUBMED 18381359
REMARK GeneRIF: a role for DENTT as a suppressor of the tumorigenic
phenotype.
REFERENCE 6 (bases 1 to 2833)
AUTHORS Ozbun,L.L., Martinez,A. and Jakowlew,S.B.
TITLE Differentially expressed nucleolar TGF-beta1 target (DENTT) shows
tissue-specific nuclear and cytoplasmic localization and increases
TGF-beta1-responsive transcription in primates
JOURNAL Biochim. Biophys. Acta 1728 (3), 163-180 (2005)
PUBMED 15823505
REMARK GeneRIF: This paper characterizes monkey DENTT cDNA and makes a
comparison with human and mouse DENTT
REFERENCE 7 (bases 1 to 2833)
AUTHORS Chai,Z., Sarcevic,B., Mawson,A. and Toh,B.H.
TITLE SET-related cell division autoantigen-1 (CDA1) arrests cell growth
JOURNAL J. Biol. Chem. 276 (36), 33665-33674 (2001)
PUBMED 11395479
REFERENCE 8 (bases 1 to 2833)
AUTHORS Ozbun,L.L., You,L., Kiang,S., Angdisen,J., Martinez,A. and
Jakowlew,S.B.
TITLE Identification of differentially expressed nucleolar TGF-beta1
target (DENTT) in human lung cancer cells that is a new member of
the TSPY/SET/NAP-1 superfamily
JOURNAL Genomics 73 (2), 179-193 (2001)
PUBMED 11318608
REFERENCE 9 (bases 1 to 2833)
AUTHORS Eichmuller,S., Usener,D., Dummer,R., Stein,A., Thiel,D. and
Schadendorf,D.
TITLE Serological detection of cutaneous T-cell lymphoma-associated
antigens
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 98 (2), 629-634 (2001)
PUBMED 11149944
REFERENCE 10 (bases 1 to 2833)
AUTHORS Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and
Wiemann,S.
TITLE Systematic subcellular localization of novel proteins identified by
large-scale cDNA sequencing
JOURNAL EMBO Rep. 1 (3), 287-292 (2000)
PUBMED 11256614
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from DA076199.1, BC024270.1 and
AI208075.1.
This sequence is a reference standard in the RefSeqGene project.
On Sep 28, 2009 this sequence version replaced gi:215490064.
Summary: This gene encodes a member of the testis-specific protein
Y-encoded, TSPY-like/SET/nucleosome assembly protein-1 superfamily.
The encoded protein is localized to the nucleolus where it
functions in chromatin remodeling and as an inhibitor of cell-cycle
progression. This protein may play a role in the suppression of
tumor growth. [provided by RefSeq, Sep 2009].
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: AK292462.1, AY040871.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025081, ERS025082 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-20 DA076199.1 1-20
21-2822 BC024270.1 1-2802
2823-2833 AI208075.1 1-11 c
FEATURES Location/Qualifiers
source 1..2833
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="X"
/map="Xp11.2"
gene 1..2833
/gene="TSPYL2"
/gene_synonym="CDA1; CINAP; CTCL; DENTT; HRIHFB2216; NP79;
SE204; TSPX"
/note="TSPY-like 2"
/db_xref="GeneID:64061"
/db_xref="HGNC:24358"
/db_xref="HPRD:06713"
/db_xref="MIM:300564"
exon 1..946
/gene="TSPYL2"
/gene_synonym="CDA1; CINAP; CTCL; DENTT; HRIHFB2216; NP79;
SE204; TSPX"
/inference="alignment:Splign:1.39.8"
variation 20
/gene="TSPYL2"
/gene_synonym="CDA1; CINAP; CTCL; DENTT; HRIHFB2216; NP79;
SE204; TSPX"
/replace="g"
/replace="t"
/db_xref="dbSNP:113491647"
variation 21
/gene="TSPYL2"
/gene_synonym="CDA1; CINAP; CTCL; DENTT; HRIHFB2216; NP79;
SE204; TSPX"
/replace="g"
/replace="t"
/db_xref="dbSNP:112437276"
misc_feature 38..40
/gene="TSPYL2"
/gene_synonym="CDA1; CINAP; CTCL; DENTT; HRIHFB2216; NP79;
SE204; TSPX"
/note="upstream in-frame stop codon"
variation 43
/gene="TSPYL2"
/gene_synonym="CDA1; CINAP; CTCL; DENTT; HRIHFB2216; NP79;
SE204; TSPX"
/replace="c"
/replace="t"
/db_xref="dbSNP:377186530"
CDS 140..2221
/gene="TSPYL2"
/gene_synonym="CDA1; CINAP; CTCL; DENTT; HRIHFB2216; NP79;
SE204; TSPX"
/note="cell division autoantigen 1; cutaneous T-cell
lymphoma-associated tumor antigen se20-4; differentially
expressed nucleolar TGF-beta1 target; CTCL tumor antigen
se20-4; testis-specific protein Y encoded-like 2;
CASK-interacting nucleosome assembly protein; TSPY-like
protein 2; nuclear protein of 79 kDa; cutaneous T-cell
lymphoma-associated antigen se20-4;
differentially-expressed nucleolar TGF-beta1 target
protein; CTCL-associated antigen se20-4"
/codon_start=1
/product="testis-specific Y-encoded-like protein 2"
/protein_id="NP_071400.1"
/db_xref="GI:11545835"
/db_xref="CCDS:CCDS14350.1"
/db_xref="GeneID:64061"
/db_xref="HGNC:24358"
/db_xref="HPRD:06713"
/db_xref="MIM:300564"
/translation="
MDRPDEGPPAKTRRLSSSESPQRDPPPPPPPPPLLRLPLPPPQQRPRLQEETEAAQVLADMRGVGLGPALPPPPPYVILEEGGIRAYFTLGAECPGWDSTIESGYGEAPPPTESLEALPTPEASGGSLEIDFQVVQSSSFGGEGALETCSAVGWAPQRLVDPKSKEEAIIIVEDEDEDERESMRSSRRRRRRRRRKQRKVKRESRERNAERMESILQALEDIQLDLEAVNIKAGKAFLRLKRKFIQMRRPFLERRDLIIQHIPGFWVKAFLNHPRISILINRRDEDIFRYLTNLQVQDLRHISMGYKMKLYFQTNPYFTNMVIVKEFQRNRSGRLVSHSTPIRWHRGQEPQARRHGNQDASHSFFSWFSNHSLPEADRIAEIIKNDLWVNPLRYYLRERGSRIKRKKQEMKKRKTRGRCEVVIMEDAPDYYAVEDIFSEISDIDETIHDIKISDFMETTDYFETTDNEITDINENICDSENPDHNEVPNNETTDNNESADDHETTDNNESADDNNENPEDNNKNTDDNEENPNNNENTYGNNFFKGGFWGSHGNNQDSSDSDNEADEASDDEDNDGNEGDNEGSDDDGNEGDNEGSDDDDRDIEYYEKVIEDFDKDQADYEDVIEIISDESVEEEGIEEGIQQDEDIYEEGNYEEEGSEDVWEEGEDSDDSDLEDVLQVPNGWANPGKRGKTG
"
misc_feature 185..187
/gene="TSPYL2"
/gene_synonym="CDA1; CINAP; CTCL; DENTT; HRIHFB2216; NP79;
SE204; TSPX"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 188..190
/gene="TSPYL2"
/gene_synonym="CDA1; CINAP; CTCL; DENTT; HRIHFB2216; NP79;
SE204; TSPX"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 191..193
/gene="TSPYL2"
/gene_synonym="CDA1; CINAP; CTCL; DENTT; HRIHFB2216; NP79;
SE204; TSPX"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q9H2G4.1); phosphorylation site"
misc_feature 197..199
/gene="TSPYL2"
/gene_synonym="CDA1; CINAP; CTCL; DENTT; HRIHFB2216; NP79;
SE204; TSPX"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q9H2G4.1); phosphorylation site"
misc_feature 197..199
/gene="TSPYL2"
/gene_synonym="CDA1; CINAP; CTCL; DENTT; HRIHFB2216; NP79;
SE204; TSPX"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/citation=[7]
/db_xref="HPRD:00310"
misc_feature 785..1333
/gene="TSPYL2"
/gene_synonym="CDA1; CINAP; CTCL; DENTT; HRIHFB2216; NP79;
SE204; TSPX"
/note="Nucleosome assembly protein (NAP); Region: NAP;
pfam00956"
/db_xref="CDD:201525"
misc_feature 818..1327
/gene="TSPYL2"
/gene_synonym="CDA1; CINAP; CTCL; DENTT; HRIHFB2216; NP79;
SE204; TSPX"
/note="(NAP-L) nucleosome assembly protein -L;
Provisional; Region: PTZ00007; cl08298"
/db_xref="CDD:186817"
misc_feature 1157..1159
/gene="TSPYL2"
/gene_synonym="CDA1; CINAP; CTCL; DENTT; HRIHFB2216; NP79;
SE204; TSPX"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/citation=[7]
/db_xref="HPRD:00310"
variation 191
/gene="TSPYL2"
/gene_synonym="CDA1; CINAP; CTCL; DENTT; HRIHFB2216; NP79;
SE204; TSPX"
/replace="c"
/replace="t"
/db_xref="dbSNP:183642206"
variation 218..219
/gene="TSPYL2"
/gene_synonym="CDA1; CINAP; CTCL; DENTT; HRIHFB2216; NP79;
SE204; TSPX"
/replace=""
/replace="ccg"
/db_xref="dbSNP:368501225"
variation 409
/gene="TSPYL2"
/gene_synonym="CDA1; CINAP; CTCL; DENTT; HRIHFB2216; NP79;
SE204; TSPX"
/replace="c"
/replace="t"
/db_xref="dbSNP:374949251"
variation 411
/gene="TSPYL2"
/gene_synonym="CDA1; CINAP; CTCL; DENTT; HRIHFB2216; NP79;
SE204; TSPX"
/replace="c"
/replace="g"
/db_xref="dbSNP:200235910"
variation 512
/gene="TSPYL2"
/gene_synonym="CDA1; CINAP; CTCL; DENTT; HRIHFB2216; NP79;
SE204; TSPX"
/replace="a"
/replace="g"
/db_xref="dbSNP:200823725"
variation 513
/gene="TSPYL2"
/gene_synonym="CDA1; CINAP; CTCL; DENTT; HRIHFB2216; NP79;
SE204; TSPX"
/replace="g"
/replace="t"
/db_xref="dbSNP:201527496"
STS 543..657
/gene="TSPYL2"
/gene_synonym="CDA1; CINAP; CTCL; DENTT; HRIHFB2216; NP79;
SE204; TSPX"
/standard_name="DXS1008E"
/db_xref="UniSTS:99636"
STS 544..657
/gene="TSPYL2"
/gene_synonym="CDA1; CINAP; CTCL; DENTT; HRIHFB2216; NP79;
SE204; TSPX"
/standard_name="DXS7563"
/db_xref="UniSTS:153986"
variation 549
/gene="TSPYL2"
/gene_synonym="CDA1; CINAP; CTCL; DENTT; HRIHFB2216; NP79;
SE204; TSPX"
/replace="c"
/replace="t"
/db_xref="dbSNP:188041795"
variation 571
/gene="TSPYL2"
/gene_synonym="CDA1; CINAP; CTCL; DENTT; HRIHFB2216; NP79;
SE204; TSPX"
/replace="a"
/replace="g"
/db_xref="dbSNP:376774006"
variation 605
/gene="TSPYL2"
/gene_synonym="CDA1; CINAP; CTCL; DENTT; HRIHFB2216; NP79;
SE204; TSPX"
/replace="c"
/replace="t"
/db_xref="dbSNP:144264921"
variation 613
/gene="TSPYL2"
/gene_synonym="CDA1; CINAP; CTCL; DENTT; HRIHFB2216; NP79;
SE204; TSPX"
/replace="a"
/replace="g"
/db_xref="dbSNP:201673878"
variation 623
/gene="TSPYL2"
/gene_synonym="CDA1; CINAP; CTCL; DENTT; HRIHFB2216; NP79;
SE204; TSPX"
/replace="c"
/replace="t"
/db_xref="dbSNP:147809315"
variation 646
/gene="TSPYL2"
/gene_synonym="CDA1; CINAP; CTCL; DENTT; HRIHFB2216; NP79;
SE204; TSPX"
/replace="c"
/replace="t"
/db_xref="dbSNP:369817731"
variation 704
/gene="TSPYL2"
/gene_synonym="CDA1; CINAP; CTCL; DENTT; HRIHFB2216; NP79;
SE204; TSPX"
/replace="a"
/replace="c"
/db_xref="dbSNP:368493284"
variation 716
/gene="TSPYL2"
/gene_synonym="CDA1; CINAP; CTCL; DENTT; HRIHFB2216; NP79;
SE204; TSPX"
/replace="a"
/replace="c"
/db_xref="dbSNP:192279149"
variation 719
/gene="TSPYL2"
/gene_synonym="CDA1; CINAP; CTCL; DENTT; HRIHFB2216; NP79;
SE204; TSPX"
/replace="a"
/replace="c"
/db_xref="dbSNP:375497514"
variation 757
/gene="TSPYL2"
/gene_synonym="CDA1; CINAP; CTCL; DENTT; HRIHFB2216; NP79;
SE204; TSPX"
/replace="a"
/replace="g"
/db_xref="dbSNP:369345152"
variation 780
/gene="TSPYL2"
/gene_synonym="CDA1; CINAP; CTCL; DENTT; HRIHFB2216; NP79;
SE204; TSPX"
/replace="a"
/replace="g"
/db_xref="dbSNP:372826412"
variation 784
/gene="TSPYL2"
/gene_synonym="CDA1; CINAP; CTCL; DENTT; HRIHFB2216; NP79;
SE204; TSPX"
/replace="c"
/replace="t"
/db_xref="dbSNP:372601931"
variation 843
/gene="TSPYL2"
/gene_synonym="CDA1; CINAP; CTCL; DENTT; HRIHFB2216; NP79;
SE204; TSPX"
/replace="a"
/replace="g"
/db_xref="dbSNP:375827801"
variation 892
/gene="TSPYL2"
/gene_synonym="CDA1; CINAP; CTCL; DENTT; HRIHFB2216; NP79;
SE204; TSPX"
/replace="c"
/replace="t"
/db_xref="dbSNP:368966106"
variation 913
/gene="TSPYL2"
/gene_synonym="CDA1; CINAP; CTCL; DENTT; HRIHFB2216; NP79;
SE204; TSPX"
/replace="c"
/replace="t"
/db_xref="dbSNP:141332236"
exon 947..1024
/gene="TSPYL2"
/gene_synonym="CDA1; CINAP; CTCL; DENTT; HRIHFB2216; NP79;
SE204; TSPX"
/inference="alignment:Splign:1.39.8"
variation 961
/gene="TSPYL2"
/gene_synonym="CDA1; CINAP; CTCL; DENTT; HRIHFB2216; NP79;
SE204; TSPX"
/replace="c"
/replace="t"
/db_xref="dbSNP:368837947"
variation 1005
/gene="TSPYL2"
/gene_synonym="CDA1; CINAP; CTCL; DENTT; HRIHFB2216; NP79;
SE204; TSPX"
/replace="a"
/replace="g"
/db_xref="dbSNP:199763926"
exon 1025..1136
/gene="TSPYL2"
/gene_synonym="CDA1; CINAP; CTCL; DENTT; HRIHFB2216; NP79;
SE204; TSPX"
/inference="alignment:Splign:1.39.8"
variation 1126
/gene="TSPYL2"
/gene_synonym="CDA1; CINAP; CTCL; DENTT; HRIHFB2216; NP79;
SE204; TSPX"
/replace="c"
/replace="t"
/db_xref="dbSNP:180791714"
variation 1131
/gene="TSPYL2"
/gene_synonym="CDA1; CINAP; CTCL; DENTT; HRIHFB2216; NP79;
SE204; TSPX"
/replace="a"
/replace="g"
/db_xref="dbSNP:201895359"
exon 1137..1282
/gene="TSPYL2"
/gene_synonym="CDA1; CINAP; CTCL; DENTT; HRIHFB2216; NP79;
SE204; TSPX"
/inference="alignment:Splign:1.39.8"
variation 1152
/gene="TSPYL2"
/gene_synonym="CDA1; CINAP; CTCL; DENTT; HRIHFB2216; NP79;
SE204; TSPX"
/replace="a"
/replace="c"
/db_xref="dbSNP:183690746"
variation 1196
/gene="TSPYL2"
/gene_synonym="CDA1; CINAP; CTCL; DENTT; HRIHFB2216; NP79;
SE204; TSPX"
/replace="c"
/replace="t"
/db_xref="dbSNP:376609801"
variation 1197
/gene="TSPYL2"
/gene_synonym="CDA1; CINAP; CTCL; DENTT; HRIHFB2216; NP79;
SE204; TSPX"
/replace="a"
/replace="g"
/db_xref="dbSNP:369549099"
variation 1204
/gene="TSPYL2"
/gene_synonym="CDA1; CINAP; CTCL; DENTT; HRIHFB2216; NP79;
SE204; TSPX"
/replace="c"
/replace="t"
/db_xref="dbSNP:145261169"
variation 1219
/gene="TSPYL2"
/gene_synonym="CDA1; CINAP; CTCL; DENTT; HRIHFB2216; NP79;
SE204; TSPX"
/replace="a"
/replace="g"
/db_xref="dbSNP:371808587"
exon 1283..1377
/gene="TSPYL2"
/gene_synonym="CDA1; CINAP; CTCL; DENTT; HRIHFB2216; NP79;
SE204; TSPX"
/inference="alignment:Splign:1.39.8"
variation 1291
/gene="TSPYL2"
/gene_synonym="CDA1; CINAP; CTCL; DENTT; HRIHFB2216; NP79;
SE204; TSPX"
/replace="g"
/replace="t"
/db_xref="dbSNP:145074661"
variation 1316
/gene="TSPYL2"
/gene_synonym="CDA1; CINAP; CTCL; DENTT; HRIHFB2216; NP79;
SE204; TSPX"
/replace="c"
/replace="t"
/db_xref="dbSNP:373147193"
exon 1378..2057
/gene="TSPYL2"
/gene_synonym="CDA1; CINAP; CTCL; DENTT; HRIHFB2216; NP79;
SE204; TSPX"
/inference="alignment:Splign:1.39.8"
variation 1388
/gene="TSPYL2"
/gene_synonym="CDA1; CINAP; CTCL; DENTT; HRIHFB2216; NP79;
SE204; TSPX"
/replace="a"
/replace="g"
/db_xref="dbSNP:200525147"
variation 1412
/gene="TSPYL2"
/gene_synonym="CDA1; CINAP; CTCL; DENTT; HRIHFB2216; NP79;
SE204; TSPX"
/replace="a"
/replace="g"
/db_xref="dbSNP:199605770"
variation 1417
/gene="TSPYL2"
/gene_synonym="CDA1; CINAP; CTCL; DENTT; HRIHFB2216; NP79;
SE204; TSPX"
/replace="c"
/replace="t"
/db_xref="dbSNP:186095471"
variation 1474
/gene="TSPYL2"
/gene_synonym="CDA1; CINAP; CTCL; DENTT; HRIHFB2216; NP79;
SE204; TSPX"
/replace="a"
/replace="g"
/db_xref="dbSNP:373431920"
variation 1553
/gene="TSPYL2"
/gene_synonym="CDA1; CINAP; CTCL; DENTT; HRIHFB2216; NP79;
SE204; TSPX"
/replace="a"
/replace="g"
/db_xref="dbSNP:149102271"
variation 1557
/gene="TSPYL2"
/gene_synonym="CDA1; CINAP; CTCL; DENTT; HRIHFB2216; NP79;
SE204; TSPX"
/replace="a"
/replace="g"
/db_xref="dbSNP:143195586"
variation 1577
/gene="TSPYL2"
/gene_synonym="CDA1; CINAP; CTCL; DENTT; HRIHFB2216; NP79;
SE204; TSPX"
/replace="a"
/replace="g"
/db_xref="dbSNP:148286087"
variation 1586
/gene="TSPYL2"
/gene_synonym="CDA1; CINAP; CTCL; DENTT; HRIHFB2216; NP79;
SE204; TSPX"
/replace="a"
/replace="g"
/db_xref="dbSNP:377693568"
variation 1605
/gene="TSPYL2"
/gene_synonym="CDA1; CINAP; CTCL; DENTT; HRIHFB2216; NP79;
SE204; TSPX"
/replace="a"
/replace="g"
/db_xref="dbSNP:201683434"
variation 1613
/gene="TSPYL2"
/gene_synonym="CDA1; CINAP; CTCL; DENTT; HRIHFB2216; NP79;
SE204; TSPX"
/replace="a"
/replace="c"
/db_xref="dbSNP:140520453"
variation 1625
/gene="TSPYL2"
/gene_synonym="CDA1; CINAP; CTCL; DENTT; HRIHFB2216; NP79;
SE204; TSPX"
/replace="a"
/replace="g"
/db_xref="dbSNP:375540357"
variation 1627
/gene="TSPYL2"
/gene_synonym="CDA1; CINAP; CTCL; DENTT; HRIHFB2216; NP79;
SE204; TSPX"
/replace="c"
/replace="t"
/db_xref="dbSNP:145686100"
variation 1632
/gene="TSPYL2"
/gene_synonym="CDA1; CINAP; CTCL; DENTT; HRIHFB2216; NP79;
SE204; TSPX"
/replace="c"
/replace="g"
/db_xref="dbSNP:138367420"
variation 1668
/gene="TSPYL2"
/gene_synonym="CDA1; CINAP; CTCL; DENTT; HRIHFB2216; NP79;
SE204; TSPX"
/replace="c"
/replace="g"
/db_xref="dbSNP:377587714"
variation 1685
/gene="TSPYL2"
/gene_synonym="CDA1; CINAP; CTCL; DENTT; HRIHFB2216; NP79;
SE204; TSPX"
/replace="a"
/replace="g"
/db_xref="dbSNP:370449744"
variation 1701
/gene="TSPYL2"
/gene_synonym="CDA1; CINAP; CTCL; DENTT; HRIHFB2216; NP79;
SE204; TSPX"
/replace="a"
/replace="g"
/db_xref="dbSNP:146112253"
variation 1724
/gene="TSPYL2"
/gene_synonym="CDA1; CINAP; CTCL; DENTT; HRIHFB2216; NP79;
SE204; TSPX"
/replace="a"
/replace="g"
/db_xref="dbSNP:374502411"
variation 1756
/gene="TSPYL2"
/gene_synonym="CDA1; CINAP; CTCL; DENTT; HRIHFB2216; NP79;
SE204; TSPX"
/replace="c"
/replace="t"
/db_xref="dbSNP:367714830"
variation 1887
/gene="TSPYL2"
/gene_synonym="CDA1; CINAP; CTCL; DENTT; HRIHFB2216; NP79;
SE204; TSPX"
/replace="a"
/replace="g"
/db_xref="dbSNP:371667688"
variation 1936
/gene="TSPYL2"
/gene_synonym="CDA1; CINAP; CTCL; DENTT; HRIHFB2216; NP79;
SE204; TSPX"
/replace="c"
/replace="t"
/db_xref="dbSNP:138904185"
variation 1954
/gene="TSPYL2"
/gene_synonym="CDA1; CINAP; CTCL; DENTT; HRIHFB2216; NP79;
SE204; TSPX"
/replace="c"
/replace="t"
/db_xref="dbSNP:374557551"
variation 1958
/gene="TSPYL2"
/gene_synonym="CDA1; CINAP; CTCL; DENTT; HRIHFB2216; NP79;
SE204; TSPX"
/replace="a"
/replace="g"
/db_xref="dbSNP:149418485"
variation 1960
/gene="TSPYL2"
/gene_synonym="CDA1; CINAP; CTCL; DENTT; HRIHFB2216; NP79;
SE204; TSPX"
/replace="a"
/replace="g"
/db_xref="dbSNP:144844790"
variation 1973
/gene="TSPYL2"
/gene_synonym="CDA1; CINAP; CTCL; DENTT; HRIHFB2216; NP79;
SE204; TSPX"
/replace="g"
/replace="t"
/db_xref="dbSNP:375418655"
variation 1981
/gene="TSPYL2"
/gene_synonym="CDA1; CINAP; CTCL; DENTT; HRIHFB2216; NP79;
SE204; TSPX"
/replace="c"
/replace="t"
/db_xref="dbSNP:369815185"
variation 1990
/gene="TSPYL2"
/gene_synonym="CDA1; CINAP; CTCL; DENTT; HRIHFB2216; NP79;
SE204; TSPX"
/replace="a"
/replace="g"
/db_xref="dbSNP:148610102"
variation 2008
/gene="TSPYL2"
/gene_synonym="CDA1; CINAP; CTCL; DENTT; HRIHFB2216; NP79;
SE204; TSPX"
/replace="c"
/replace="g"
/db_xref="dbSNP:368538873"
variation 2026
/gene="TSPYL2"
/gene_synonym="CDA1; CINAP; CTCL; DENTT; HRIHFB2216; NP79;
SE204; TSPX"
/replace="c"
/replace="t"
/db_xref="dbSNP:371990751"
variation 2027
/gene="TSPYL2"
/gene_synonym="CDA1; CINAP; CTCL; DENTT; HRIHFB2216; NP79;
SE204; TSPX"
/replace="a"
/replace="g"
/db_xref="dbSNP:375123038"
variation 2033
/gene="TSPYL2"
/gene_synonym="CDA1; CINAP; CTCL; DENTT; HRIHFB2216; NP79;
SE204; TSPX"
/replace="a"
/replace="g"
/db_xref="dbSNP:147753284"
variation 2049
/gene="TSPYL2"
/gene_synonym="CDA1; CINAP; CTCL; DENTT; HRIHFB2216; NP79;
SE204; TSPX"
/replace="c"
/replace="t"
/db_xref="dbSNP:368159646"
exon 2058..2828
/gene="TSPYL2"
/gene_synonym="CDA1; CINAP; CTCL; DENTT; HRIHFB2216; NP79;
SE204; TSPX"
/inference="alignment:Splign:1.39.8"
variation 2058
/gene="TSPYL2"
/gene_synonym="CDA1; CINAP; CTCL; DENTT; HRIHFB2216; NP79;
SE204; TSPX"
/replace="a"
/replace="g"
/db_xref="dbSNP:147373370"
variation 2059
/gene="TSPYL2"
/gene_synonym="CDA1; CINAP; CTCL; DENTT; HRIHFB2216; NP79;
SE204; TSPX"
/replace="c"
/replace="t"
/db_xref="dbSNP:139596270"
variation 2082
/gene="TSPYL2"
/gene_synonym="CDA1; CINAP; CTCL; DENTT; HRIHFB2216; NP79;
SE204; TSPX"
/replace="a"
/replace="g"
/db_xref="dbSNP:145146062"
variation 2127
/gene="TSPYL2"
/gene_synonym="CDA1; CINAP; CTCL; DENTT; HRIHFB2216; NP79;
SE204; TSPX"
/replace="a"
/replace="t"
/db_xref="dbSNP:375981547"
variation 2129
/gene="TSPYL2"
/gene_synonym="CDA1; CINAP; CTCL; DENTT; HRIHFB2216; NP79;
SE204; TSPX"
/replace="a"
/replace="g"
/db_xref="dbSNP:150975914"
variation 2146
/gene="TSPYL2"
/gene_synonym="CDA1; CINAP; CTCL; DENTT; HRIHFB2216; NP79;
SE204; TSPX"
/replace="c"
/replace="g"
/db_xref="dbSNP:369016861"
variation 2155
/gene="TSPYL2"
/gene_synonym="CDA1; CINAP; CTCL; DENTT; HRIHFB2216; NP79;
SE204; TSPX"
/replace="c"
/replace="t"
/db_xref="dbSNP:372973628"
variation 2168
/gene="TSPYL2"
/gene_synonym="CDA1; CINAP; CTCL; DENTT; HRIHFB2216; NP79;
SE204; TSPX"
/replace="c"
/replace="t"
/db_xref="dbSNP:377270693"
variation 2195
/gene="TSPYL2"
/gene_synonym="CDA1; CINAP; CTCL; DENTT; HRIHFB2216; NP79;
SE204; TSPX"
/replace="c"
/replace="g"
/db_xref="dbSNP:370419229"
variation 2199
/gene="TSPYL2"
/gene_synonym="CDA1; CINAP; CTCL; DENTT; HRIHFB2216; NP79;
SE204; TSPX"
/replace="a"
/replace="g"
/db_xref="dbSNP:200976056"
variation 2204
/gene="TSPYL2"
/gene_synonym="CDA1; CINAP; CTCL; DENTT; HRIHFB2216; NP79;
SE204; TSPX"
/replace="a"
/replace="g"
/db_xref="dbSNP:181418147"
variation 2210
/gene="TSPYL2"
/gene_synonym="CDA1; CINAP; CTCL; DENTT; HRIHFB2216; NP79;
SE204; TSPX"
/replace="a"
/replace="g"
/db_xref="dbSNP:201621148"
variation 2226
/gene="TSPYL2"
/gene_synonym="CDA1; CINAP; CTCL; DENTT; HRIHFB2216; NP79;
SE204; TSPX"
/replace="g"
/replace="t"
/db_xref="dbSNP:369838024"
variation 2244
/gene="TSPYL2"
/gene_synonym="CDA1; CINAP; CTCL; DENTT; HRIHFB2216; NP79;
SE204; TSPX"
/replace="a"
/replace="c"
/db_xref="dbSNP:374768603"
variation 2246
/gene="TSPYL2"
/gene_synonym="CDA1; CINAP; CTCL; DENTT; HRIHFB2216; NP79;
SE204; TSPX"
/replace="c"
/replace="t"
/db_xref="dbSNP:138436361"
variation 2248
/gene="TSPYL2"
/gene_synonym="CDA1; CINAP; CTCL; DENTT; HRIHFB2216; NP79;
SE204; TSPX"
/replace="c"
/replace="t"
/db_xref="dbSNP:377642189"
STS 2378..2565
/gene="TSPYL2"
/gene_synonym="CDA1; CINAP; CTCL; DENTT; HRIHFB2216; NP79;
SE204; TSPX"
/standard_name="RH99258"
/db_xref="UniSTS:86666"
variation 2403
/gene="TSPYL2"
/gene_synonym="CDA1; CINAP; CTCL; DENTT; HRIHFB2216; NP79;
SE204; TSPX"
/replace="a"
/replace="g"
/db_xref="dbSNP:79703928"
variation 2441
/gene="TSPYL2"
/gene_synonym="CDA1; CINAP; CTCL; DENTT; HRIHFB2216; NP79;
SE204; TSPX"
/replace="c"
/replace="t"
/db_xref="dbSNP:190372740"
variation 2500
/gene="TSPYL2"
/gene_synonym="CDA1; CINAP; CTCL; DENTT; HRIHFB2216; NP79;
SE204; TSPX"
/replace="a"
/replace="c"
/db_xref="dbSNP:113822334"
variation 2584
/gene="TSPYL2"
/gene_synonym="CDA1; CINAP; CTCL; DENTT; HRIHFB2216; NP79;
SE204; TSPX"
/replace="a"
/replace="g"
/db_xref="dbSNP:112694949"
variation 2633
/gene="TSPYL2"
/gene_synonym="CDA1; CINAP; CTCL; DENTT; HRIHFB2216; NP79;
SE204; TSPX"
/replace="a"
/replace="g"
/db_xref="dbSNP:368637505"
variation 2646
/gene="TSPYL2"
/gene_synonym="CDA1; CINAP; CTCL; DENTT; HRIHFB2216; NP79;
SE204; TSPX"
/replace="c"
/replace="t"
/db_xref="dbSNP:113408339"
variation 2726..2737
/gene="TSPYL2"
/gene_synonym="CDA1; CINAP; CTCL; DENTT; HRIHFB2216; NP79;
SE204; TSPX"
/replace=""
/replace="ttgcggtattct"
/db_xref="dbSNP:199545161"
polyA_signal 2801..2806
/gene="TSPYL2"
/gene_synonym="CDA1; CINAP; CTCL; DENTT; HRIHFB2216; NP79;
SE204; TSPX"
variation 2818
/gene="TSPYL2"
/gene_synonym="CDA1; CINAP; CTCL; DENTT; HRIHFB2216; NP79;
SE204; TSPX"
/replace="a"
/replace="g"
/db_xref="dbSNP:372174612"
polyA_site 2828
/gene="TSPYL2"
/gene_synonym="CDA1; CINAP; CTCL; DENTT; HRIHFB2216; NP79;
SE204; TSPX"
ORIGIN
gaacgccagagcgaggtggtgaggagagctggttgcgtgagtctcctcagctctgcttaccggtgcgactagcggcagcgacgcggctaaaagcgaaggggcgagtgcgagtcccctgagctgtacgaacgcggtcgccatggaccgcccagatgaggggcctccggccaagacccgccgcctgagcagctccgagtctccacagcgcgacccgcccccgccgccgccgccgccgccgctcctccgactgccgctgcctccaccccagcagcgcccgaggctccaggaggaaacggaggcggcacaggtgctggccgatatgaggggggtgggactgggccccgcgctgcccccgccgcctccctatgtcattctcgaggagggggggatccgcgcatacttcacgctcggtgctgagtgtcccggctgggattctaccatcgagtcggggtatggggaggcgcccccgcccacggagagcctggaagcactccccactcctgaggcctcgggggggagcctggaaatcgattttcaggttgtacagtcgagcagttttggtggagagggggccctagaaacctgtagcgcagtggggtgggcgccccagaggttagttgacccgaagagcaaggaagaggcgatcatcatagtggaggatgaggatgaggatgagcgggagagtatgaggagcagcaggaggcggcggcggcggcggaggaggaagcagaggaaggtgaagagggaaagcagagagagaaatgccgagaggatggagagcatcctgcaggcactggaggatattcagctggatctggaggcagtgaacatcaaggcaggcaaagccttcctgcgtctcaagcgcaagttcatccagatgcgaagacccttcctggagcgcagagacctcatcatccagcatatcccaggcttctgggtcaaagcattcctcaaccaccccagaatttcaattttgatcaaccgacgtgatgaagacattttccgctacttgaccaatctgcaggtacaggatctcagacatatctccatgggctacaaaatgaagctgtacttccagactaacccctacttcacaaacatggtgattgtcaaggagttccagcgcaaccgctcaggccggctggtgtctcactcaaccccaatccgctggcaccggggccaggaaccccaggcccgtcgtcacgggaaccaggatgcgagccacagctttttcagctggttctcaaaccatagcctcccagaggctgacaggattgctgagattatcaagaatgatctgtgggttaaccctctacgctactacctgagagaaaggggctccaggataaagagaaagaagcaagaaatgaagaaacgtaaaaccaggggcagatgtgaggtggtgatcatggaagacgcccctgactattatgcagtggaagacattttcagcgagatctcagacattgatgagacaattcatgacatcaagatctctgacttcatggagaccaccgactacttcgagaccactgacaatgagataactgacatcaatgagaacatctgcgacagcgagaatcctgaccacaatgaggtccccaacaacgagaccactgataacaacgagagtgctgatgaccacgaaaccactgacaacaatgagagtgcagatgacaacaacgagaatcctgaagacaataacaagaacactgatgacaacgaagagaaccctaacaacaacgagaacacttacggcaacaacttcttcaaaggtggcttctggggcagccatggcaacaaccaggacagcagcgacagtgacaatgaagcagatgaggccagtgatgatgaagataatgatggcaacgaaggtgacaatgagggcagtgatgatgatggcaatgaaggtgacaatgaaggcagcgatgatgacgacagagacattgagtactatgagaaagttattgaagactttgacaaggatcaggctgactacgaggacgtgatagagatcatctcagacgaatcagtggaagaagagggcattgaggaaggcatccagcaagatgaggacatctatgaggaaggaaactatgaggaggaaggaagtgaagatgtctgggaagaaggggaagattcggacgactctgacctagaggatgtgcttcaggtcccaaacggttgggccaatccggggaagagggggaaaaccggataagggttttccccttttggggatcacctctctgtatcccccacccactatcccatttgccctcctcctcagctagggccacgcggccccacattgcacttctggggggtgaccgacttcgtacacgggtttaaagtttatttttatggtttagtcattgcagagttcttattttggggggagggaaagggggctagtccccttcttttggccctccgcccccgcaggcttctgtgtgctgctaactgtatttattgtgatgccttggtcagggcccctctacccacttctcccagtcagttgtggccccagcccctctccctgtgctgtgtggagtggacaccctgacccccgaagcggggagggccgctgtggccttcgtcacagccgcgcagtgcccatggaggcgctgctgccaccttcctctcccaagttctttctccatccctctcctcttcccgccgcgccgctagcccgcctcggtgtctatgcaaggccgcttcgccattgcggtattctttgcggtattcttgtccccgtcccccagaaggctcgcctctccccgtggaccctgttaatcccaataaaattctgagcaagttcagagtgcaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:64061 -> Molecular function: GO:0000182 [rDNA binding] evidence: NAS
GeneID:64061 -> Biological process: GO:0006334 [nucleosome assembly] evidence: IEA
GeneID:64061 -> Biological process: GO:0006351 [transcription, DNA-dependent] evidence: IEA
GeneID:64061 -> Biological process: GO:0006355 [regulation of transcription, DNA-dependent] evidence: IEA
GeneID:64061 -> Biological process: GO:0006987 [activation of signaling protein activity involved in unfolded protein response] evidence: TAS
GeneID:64061 -> Biological process: GO:0007049 [cell cycle] evidence: IEA
GeneID:64061 -> Biological process: GO:0008156 [negative regulation of DNA replication] evidence: IDA
GeneID:64061 -> Biological process: GO:0009966 [regulation of signal transduction] evidence: NAS
GeneID:64061 -> Biological process: GO:0016568 [chromatin modification] evidence: IEA
GeneID:64061 -> Biological process: GO:0030308 [negative regulation of cell growth] evidence: IDA
GeneID:64061 -> Biological process: GO:0030968 [endoplasmic reticulum unfolded protein response] evidence: TAS
GeneID:64061 -> Biological process: GO:0044267 [cellular protein metabolic process] evidence: TAS
GeneID:64061 -> Biological process: GO:0045786 [negative regulation of cell cycle] evidence: NAS
GeneID:64061 -> Biological process: GO:0045859 [regulation of protein kinase activity] evidence: IDA
GeneID:64061 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
GeneID:64061 -> Cellular component: GO:0005654 [nucleoplasm] evidence: TAS
GeneID:64061 -> Cellular component: GO:0005730 [nucleolus] evidence: IDA
GeneID:64061 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA
GeneID:64061 -> Cellular component: GO:0005813 [centrosome] evidence: IDA
GeneID:64061 -> Cellular component: GO:0005886 [plasma membrane] evidence: IDA
by
@meso_cacase at
DBCLS
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