GGRNA Home | Help | Advanced search

2024-03-28 23:46:41, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_021105               2228 bp    mRNA    linear   PRI 16-JUN-2013
DEFINITION  Homo sapiens phospholipid scramblase 1 (PLSCR1), mRNA.
ACCESSION   NM_021105
VERSION     NM_021105.2  GI:176865826
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2228)
  AUTHORS   Kusano,S. and Eizuru,Y.
  TITLE     Interaction of the phospholipid scramblase 1 with HIV-1 Tat results
            in the repression of Tat-dependent transcription
  JOURNAL   Biochem. Biophys. Res. Commun. 433 (4), 438-444 (2013)
   PUBMED   23501106
  REMARK    GeneRIF: Overexpression of PLSCR1 efficiently represses the
            Tat-dependent transactivation of the HIV-1 long terminal repeat
            (LTR) and reduces the nuclear translocation of Tat.
REFERENCE   2  (bases 1 to 2228)
  AUTHORS   Ory,S., Ceridono,M., Momboisse,F., Houy,S., Chasserot-Golaz,S.,
            Heintz,D., Calco,V., Haeberle,A.M., Espinoza,F.A., Sims,P.J.,
            Bailly,Y., Bader,M.F. and Gasman,S.
  TITLE     Phospholipid scramblase-1-induced lipid reorganization regulates
            compensatory endocytosis in neuroendocrine cells
  JOURNAL   J. Neurosci. 33 (8), 3545-3556 (2013)
   PUBMED   23426682
  REMARK    GeneRIF: Calcium-dependent PLSCR-1 activity is required for
            compensatory endocytosis (but not for exocytosis) in neuroendocrine
            cells.
REFERENCE   3  (bases 1 to 2228)
  AUTHORS   Amengual,O., Atsumi,T., Oku,K., Suzuki,E., Horita,T., Yasuda,S. and
            Koike,T.
  TITLE     Phospholipid scramblase 1 expression is enhanced in patients with
            antiphospholipid syndrome
  JOURNAL   Mod Rheumatol 23 (1), 81-88 (2013)
   PUBMED   22526829
  REMARK    GeneRIF: Phospholipid scramblase 1 expression is enhanced in
            patients with antiphospholipid syndrome.
REFERENCE   4  (bases 1 to 2228)
  AUTHORS   Kusano,S. and Eizuru,Y.
  TITLE     Human phospholipid scramblase 1 interacts with and regulates
            transactivation of HTLV-1 Tax
  JOURNAL   Virology 432 (2), 343-352 (2012)
   PUBMED   22789739
  REMARK    GeneRIF: PLSCR1 may play an important role in the IFN-mediated
            repression of Tax-dependent transactivation during HTLV-1
            infection.
REFERENCE   5  (bases 1 to 2228)
  AUTHORS   Cui,W., Li,S.Y., Du,J.F., Zhu,Z.M. and An,P.
  TITLE     Silencing phospholipid scramblase 1 expression by RNA interference
            in colorectal cancer and metastatic liver cancer
  JOURNAL   HBPD INT 11 (4), 393-400 (2012)
   PUBMED   22893466
  REMARK    GeneRIF: PLSCR1 is overexpressed in colorectal cancer and
            metastatic liver cancer. Silencing of PLSCR1 by siRNA inhibits the
            proliferation, adhesion, migration and invasion of tumor cells.
REFERENCE   6  (bases 1 to 2228)
  AUTHORS   Kasukabe,T., Kobayashi,H., Kaneko,Y., Okabe-Kado,J. and Honma,Y.
  TITLE     Identity of human normal counterpart (MmTRA1b) of mouse
            leukemogenesis-associated gene (MmTRA1a) product as plasma membrane
            phospholipid scramblase and chromosome mapping of the human
            MmTRA1b/phospholipid scramblase gene
  JOURNAL   Biochem. Biophys. Res. Commun. 249 (2), 449-455 (1998)
   PUBMED   9712717
REFERENCE   7  (bases 1 to 2228)
  AUTHORS   Zhao,J., Zhou,Q., Wiedmer,T. and Sims,P.J.
  TITLE     Palmitoylation of phospholipid scramblase is required for normal
            function in promoting Ca2+-activated transbilayer movement of
            membrane phospholipids
  JOURNAL   Biochemistry 37 (18), 6361-6366 (1998)
   PUBMED   9572851
REFERENCE   8  (bases 1 to 2228)
  AUTHORS   Zhou,Q., Sims,P.J. and Wiedmer,T.
  TITLE     Identity of a conserved motif in phospholipid scramblase that is
            required for Ca2+-accelerated transbilayer movement of membrane
            phospholipids
  JOURNAL   Biochemistry 37 (8), 2356-2360 (1998)
   PUBMED   9485382
REFERENCE   9  (bases 1 to 2228)
  AUTHORS   Zhou,Q., Zhao,J., Stout,J.G., Luhm,R.A., Wiedmer,T. and Sims,P.J.
  TITLE     Molecular cloning of human plasma membrane phospholipid scramblase.
            A protein mediating transbilayer movement of plasma membrane
            phospholipids
  JOURNAL   J. Biol. Chem. 272 (29), 18240-18244 (1997)
   PUBMED   9218461
REFERENCE   10 (bases 1 to 2228)
  AUTHORS   Basse,F., Stout,J.G., Sims,P.J. and Wiedmer,T.
  TITLE     Isolation of an erythrocyte membrane protein that mediates
            Ca2+-dependent transbilayer movement of phospholipid
  JOURNAL   J. Biol. Chem. 271 (29), 17205-17210 (1996)
   PUBMED   8663431
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DR005513.1, AF098642.1 and BC032718.1.
            On Apr 8, 2008 this sequence version replaced gi:10863876.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC032718.1, AB006746.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           ERS025081, ERS025082 [ECO:0000350]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-133               DR005513.1         26-158
            134-284             AF098642.1         1-151
            285-2228            BC032718.1         33-1976
FEATURES             Location/Qualifiers
     source          1..2228
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q23"
     gene            1..2228
                     /gene="PLSCR1"
                     /gene_synonym="MMTRA1B"
                     /note="phospholipid scramblase 1"
                     /db_xref="GeneID:5359"
                     /db_xref="HGNC:9092"
                     /db_xref="HPRD:08855"
                     /db_xref="MIM:604170"
     exon            1..375
                     /gene="PLSCR1"
                     /gene_synonym="MMTRA1B"
                     /inference="alignment:Splign:1.39.8"
     STS             134..375
                     /gene="PLSCR1"
                     /gene_synonym="MMTRA1B"
                     /standard_name="PMC229255P5"
                     /db_xref="UniSTS:272172"
     misc_feature    257..259
                     /gene="PLSCR1"
                     /gene_synonym="MMTRA1B"
                     /note="upstream in-frame stop codon"
     variation       285
                     /gene="PLSCR1"
                     /gene_synonym="MMTRA1B"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1061307"
     exon            376..401
                     /gene="PLSCR1"
                     /gene_synonym="MMTRA1B"
                     /inference="alignment:Splign:1.39.8"
     CDS             389..1345
                     /gene="PLSCR1"
                     /gene_synonym="MMTRA1B"
                     /note="PL scramblase 1; erythrocyte phospholipid
                     scramblase; ca(2+)-dependent phospholipid scramblase 1"
                     /codon_start=1
                     /product="phospholipid scramblase 1"
                     /protein_id="NP_066928.1"
                     /db_xref="GI:10863877"
                     /db_xref="CCDS:CCDS3135.1"
                     /db_xref="GeneID:5359"
                     /db_xref="HGNC:9092"
                     /db_xref="HPRD:08855"
                     /db_xref="MIM:604170"
                     /translation="
MDKQNSQMNASHPETNLPVGYPPQYPPTAFQGPPGYSGYPGPQVSYPPPPAGHSGPGPAGFPVPNQPVYNQPVYNQPVGAAGVPWMPAPQPPLNCPPGLEYLSQIDQILIHQQIELLEVLTGFETNNKYEIKNSFGQRVYFAAEDTDCCTRNCCGPSRPFTLRIIDNMGQEVITLERPLRCSSCCCPCCLQEIEIQAPPGVPIGYVIQTWHPCLPKFTIQNEKREDVLKISGPCVVCSCCGDVDFEIKSLDEQCVVGKISKHWTGILREAFTDADNFGIQFPLDLDVKMKAVMIGACFLIDFMFFESTGSQEQKSGVW
"
     misc_feature    440..466
                     /gene="PLSCR1"
                     /gene_synonym="MMTRA1B"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (O15162.1);
                     Region: SH3-binding 1 (Potential)"
     misc_feature    452..463
                     /gene="PLSCR1"
                     /gene_synonym="MMTRA1B"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (O15162.1);
                     Region: WW-binding 1 (Potential)"
     misc_feature    485..496
                     /gene="PLSCR1"
                     /gene_synonym="MMTRA1B"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (O15162.1);
                     Region: WW-binding 2 (Potential)"
     misc_feature    512..538
                     /gene="PLSCR1"
                     /gene_synonym="MMTRA1B"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (O15162.1);
                     Region: SH3-binding 2 (Potential)"
     misc_feature    593..595
                     /gene="PLSCR1"
                     /gene_synonym="MMTRA1B"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphotyrosine, by ABL; propagated from
                     UniProtKB/Swiss-Prot (O15162.1); phosphorylation site"
     misc_feature    593..595
                     /gene="PLSCR1"
                     /gene_synonym="MMTRA1B"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
                     /db_xref="HPRD:01809"
     misc_feature    608..610
                     /gene="PLSCR1"
                     /gene_synonym="MMTRA1B"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphotyrosine, by ABL; propagated from
                     UniProtKB/Swiss-Prot (O15162.1); phosphorylation site"
     misc_feature    608..610
                     /gene="PLSCR1"
                     /gene_synonym="MMTRA1B"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
                     /db_xref="HPRD:01809"
     misc_feature    638..664
                     /gene="PLSCR1"
                     /gene_synonym="MMTRA1B"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (O15162.1);
                     Region: SH3-binding 3 (Potential)"
     misc_feature    644..1309
                     /gene="PLSCR1"
                     /gene_synonym="MMTRA1B"
                     /note="Scramblase; Region: Scramblase; pfam03803"
                     /db_xref="CDD:190757"
     misc_feature    869..871
                     /gene="PLSCR1"
                     /gene_synonym="MMTRA1B"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphothreonine, by PKC; propagated from
                     UniProtKB/Swiss-Prot (O15162.1); phosphorylation site"
     misc_feature    869..871
                     /gene="PLSCR1"
                     /gene_synonym="MMTRA1B"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
                     /db_xref="HPRD:01501"
     misc_feature    1157..1186
                     /gene="PLSCR1"
                     /gene_synonym="MMTRA1B"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (O15162.1);
                     Region: Nuclear localization signal"
     misc_feature    1253..1303
                     /gene="PLSCR1"
                     /gene_synonym="MMTRA1B"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (O15162.1);
                     transmembrane region"
     exon            402..482
                     /gene="PLSCR1"
                     /gene_synonym="MMTRA1B"
                     /inference="alignment:Splign:1.39.8"
     exon            483..700
                     /gene="PLSCR1"
                     /gene_synonym="MMTRA1B"
                     /inference="alignment:Splign:1.39.8"
     exon            701..743
                     /gene="PLSCR1"
                     /gene_synonym="MMTRA1B"
                     /inference="alignment:Splign:1.39.8"
     exon            744..964
                     /gene="PLSCR1"
                     /gene_synonym="MMTRA1B"
                     /inference="alignment:Splign:1.39.8"
     exon            965..1126
                     /gene="PLSCR1"
                     /gene_synonym="MMTRA1B"
                     /inference="alignment:Splign:1.39.8"
     exon            1127..1288
                     /gene="PLSCR1"
                     /gene_synonym="MMTRA1B"
                     /inference="alignment:Splign:1.39.8"
     variation       1172
                     /gene="PLSCR1"
                     /gene_synonym="MMTRA1B"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:343320"
     exon            1289..2210
                     /gene="PLSCR1"
                     /gene_synonym="MMTRA1B"
                     /inference="alignment:Splign:1.39.8"
     STS             1317..1451
                     /gene="PLSCR1"
                     /gene_synonym="MMTRA1B"
                     /standard_name="SHGC-77431"
                     /db_xref="UniSTS:48456"
     STS             1950..2081
                     /gene="PLSCR1"
                     /gene_synonym="MMTRA1B"
                     /standard_name="SHGC-77437"
                     /db_xref="UniSTS:51388"
ORIGIN      
caccggacaaacgtctctggagtctctccaatgagcaagaaagcaagtcgggggtaggggaggggcctcacaccagggggtgggcgcagtccctcctccagctccttcaccctccagtagtctcgtgggtccccgagcgccagcgcgggaaccgggaaaaggaaaccgtgttgtgtacgtaagattcaggaaacgaaaccaggagccgcgggtgttggcgcaaaggttactcccagacccttttccggctgacttctgagaaggttgcgcagcagctgtgcccggcagtctagaggcgcagaagaggaagccatcgcctggccccggctctctggaccttgtctcgctcgggagcggaaacagcggcagccagagaactgttttaatcatggacaaacaaaactcacagatgaatgcttctcacccggaaacaaacttgccagttgggtatcctcctcagtatccaccgacagcattccaaggacctccaggatatagtggctaccctgggccccaggtcagctacccacccccaccagccggccattcaggtcctggcccagctggctttcctgtcccaaatcagccagtgtataatcagccagtatataatcagccagttggagctgcaggggtaccatggatgccagcgccacagcctccattaaactgtccacctggattagaatatttaagtcagatagatcagatactgattcatcagcaaattgaacttctggaagttttaacaggttttgaaactaataacaaatatgaaattaagaacagctttggacagagggtttactttgcagcggaagatactgattgctgtacccgaaattgctgtgggccatctagaccttttaccttgaggattattgataatatgggtcaagaagtcataactctggagagaccactaagatgtagcagctgttgttgtccctgctgccttcaggagatagaaatccaagctcctcctggtgtaccaataggttatgttattcagacttggcacccatgtctaccaaagtttacaattcaaaatgagaaaagagaggatgtactaaaaataagtggtccatgtgttgtgtgcagctgttgtggagatgttgattttgagattaaatctcttgatgaacagtgtgtggttggcaaaatttccaagcactggactggaattttgagagaggcatttacagacgctgataactttggaatccagttccctttagaccttgatgttaaaatgaaagctgtaatgattggtgcctgtttcctcattgacttcatgttttttgaaagcactggcagccaggaacaaaaatcaggagtgtggtagtggattagtgaaagtctcctcaggaaatctgaagtctgtatattgattgagactatctaaactcatacctgtatgaattaagctgtaaggcctgtagctctggttgtatacttttgcttttcaaattatagtttatcttctgtataactgatttataaaggtttttgtacattttttaatactcattgtcaatttgagaaaaaggacatatgagtttttgcatttattaatgaaacttcctttgaaaaactgctttgaattatgatctctgattcattgtccattttactaccaaatattaactaaggccttattaatttttatataaattatatcttgtcctattaaatctagttacaatttatttcatgcataagagctaatgttattttgcaaatgccatatattcaaaaaagctcaaagataattttctttactattatgttcaaataatattcaatatgcatattatctttaaaaagttaaatgtttttttaatcttcaagaaatcatgctacacttaacttctcctagaagctaatctataccataatattttcatattcacaagatattaaattaccaattttcaaattattgttagtaaagaacaaaatgattctctcccaaagaaagacacattttaaatactccttcactctaaaactctggtattataacttttgaaagttaatatttctacatgaaatgtttagctcttacactctatccttcctagaaaatggtaattgagattactcagatattaattaaatacaatatcatatatatattcacagagtataaacctaaataatgatctattagattcaaatatttgaaataaaaacttgatttttttgtaaaaaaaaaaaaaaaaaaa
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:5359 -> Molecular function: GO:0001077 [RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription] evidence: IDA
            GeneID:5359 -> Molecular function: GO:0003677 [DNA binding] evidence: IEA
            GeneID:5359 -> Molecular function: GO:0005154 [epidermal growth factor receptor binding] evidence: IPI
            GeneID:5359 -> Molecular function: GO:0005509 [calcium ion binding] evidence: IDA
            GeneID:5359 -> Molecular function: GO:0005509 [calcium ion binding] evidence: NAS
            GeneID:5359 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
            GeneID:5359 -> Molecular function: GO:0017124 [SH3 domain binding] evidence: IDA
            GeneID:5359 -> Molecular function: GO:0017128 [phospholipid scramblase activity] evidence: IDA
            GeneID:5359 -> Molecular function: GO:0019899 [enzyme binding] evidence: IPI
            GeneID:5359 -> Molecular function: GO:0042609 [CD4 receptor binding] evidence: IPI
            GeneID:5359 -> Biological process: GO:0006659 [phosphatidylserine biosynthetic process] evidence: ISS
            GeneID:5359 -> Biological process: GO:0006915 [apoptotic process] evidence: IDA
            GeneID:5359 -> Biological process: GO:0006953 [acute-phase response] evidence: ISS
            GeneID:5359 -> Biological process: GO:0010628 [positive regulation of gene expression] evidence: IMP
            GeneID:5359 -> Biological process: GO:0017121 [phospholipid scrambling] evidence: IDA
            GeneID:5359 -> Biological process: GO:0030168 [platelet activation] evidence: NAS
            GeneID:5359 -> Biological process: GO:0033003 [regulation of mast cell activation] evidence: ISS
            GeneID:5359 -> Biological process: GO:0035456 [response to interferon-beta] evidence: IMP
            GeneID:5359 -> Biological process: GO:0045071 [negative regulation of viral genome replication] evidence: IMP
            GeneID:5359 -> Biological process: GO:0045089 [positive regulation of innate immune response] evidence: IMP
            GeneID:5359 -> Biological process: GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] evidence: IDA
            GeneID:5359 -> Biological process: GO:0051607 [defense response to virus] evidence: IMP
            GeneID:5359 -> Biological process: GO:0060368 [regulation of Fc receptor mediated stimulatory signaling pathway] evidence: ISS
            GeneID:5359 -> Biological process: GO:2000373 [positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity] evidence: IDA
            GeneID:5359 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
            GeneID:5359 -> Cellular component: GO:0005730 [nucleolus] evidence: IDA
            GeneID:5359 -> Cellular component: GO:0005794 [Golgi apparatus] evidence: IDA
            GeneID:5359 -> Cellular component: GO:0005829 [cytosol] evidence: IDA
            GeneID:5359 -> Cellular component: GO:0005886 [plasma membrane] evidence: IDA
            GeneID:5359 -> Cellular component: GO:0005887 [integral to plasma membrane] evidence: IDA
            GeneID:5359 -> Cellular component: GO:0031012 [extracellular matrix] evidence: IDA
            GeneID:5359 -> Cellular component: GO:0045121 [membrane raft] evidence: IDA

by @meso_cacase at DBCLS
This page is licensed under a Creative Commons Attribution 2.1 Japan License.