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2024-03-29 15:45:01, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_021101               3452 bp    mRNA    linear   PRI 16-JUN-2013
DEFINITION  Homo sapiens claudin 1 (CLDN1), mRNA.
ACCESSION   NM_021101
VERSION     NM_021101.4  GI:296785063
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3452)
  AUTHORS   Qin,W., Ren,Q., Liu,T., Huang,Y. and Wang,J.
  TITLE     MicroRNA-155 is a novel suppressor of ovarian cancer-initiating
            cells that targets CLDN1
  JOURNAL   FEBS Lett. 587 (9), 1434-1439 (2013)
   PUBMED   23523916
  REMARK    GeneRIF: miR-155 may prevent tumorigenesis in human ovarian cancer
            through downregulation of CLDN1
REFERENCE   2  (bases 1 to 3452)
  AUTHORS   Fortier,A.M., Asselin,E. and Cadrin,M.
  TITLE     Keratin 8 and 18 loss in epithelial cancer cells increases
            collective cell migration and cisplatin sensitivity through
            claudin1 up-regulation
  JOURNAL   J. Biol. Chem. 288 (16), 11555-11571 (2013)
   PUBMED   23449973
  REMARK    GeneRIF: Keratin 8 and 18 loss in epithelial cancer cells increases
            collective cell migration and cisplatin sensitivity through
            claudin1 up-regulation.
REFERENCE   3  (bases 1 to 3452)
  AUTHORS   Singh,A.B., Sharma,A. and Dhawan,P.
  TITLE     Claudin-1 expression confers resistance to anoikis in colon cancer
            cells in a Src-dependent manner
  JOURNAL   Carcinogenesis 33 (12), 2538-2547 (2012)
   PUBMED   22941059
  REMARK    GeneRIF: Claudin-1 expression confers resistance to anoikis in
            colon cancer cells in a Src-dependent manner.
REFERENCE   4  (bases 1 to 3452)
  AUTHORS   Davis,C., Harris,H.J., Hu,K., Drummer,H.E., McKeating,J.A.,
            Mullins,J.G. and Balfe,P.
  TITLE     In silico directed mutagenesis identifies the CD81/claudin-1
            hepatitis C virus receptor interface
  JOURNAL   Cell. Microbiol. 14 (12), 1892-1903 (2012)
   PUBMED   22897233
  REMARK    GeneRIF: Fluorescent Resonance Energy Transfer studies confirm a
            role for these CD81 residues in claudin-1 association and Hepatitis
            C virus infection.
REFERENCE   5  (bases 1 to 3452)
  AUTHORS   Bhat,A.A., Sharma,A., Pope,J., Krishnan,M., Washington,M.K.,
            Singh,A.B. and Dhawan,P.
  TITLE     Caudal homeobox protein Cdx-2 cooperates with Wnt pathway to
            regulate claudin-1 expression in colon cancer cells
  JOURNAL   PLoS ONE 7 (6), E37174 (2012)
   PUBMED   22719836
  REMARK    GeneRIF: conclude that homeodomain transcription factors Cdx1, Cdx2
            and GATA4 regulate claudin-1 gene expression in human colon cancer
            cells
REFERENCE   6  (bases 1 to 3452)
  AUTHORS   Itoh,M., Furuse,M., Morita,K., Kubota,K., Saitou,M. and Tsukita,S.
  TITLE     Direct binding of three tight junction-associated MAGUKs, ZO-1,
            ZO-2, and ZO-3, with the COOH termini of claudins
  JOURNAL   J. Cell Biol. 147 (6), 1351-1363 (1999)
   PUBMED   10601346
REFERENCE   7  (bases 1 to 3452)
  AUTHORS   Furuse,M., Sasaki,H. and Tsukita,S.
  TITLE     Manner of interaction of heterogeneous claudin species within and
            between tight junction strands
  JOURNAL   J. Cell Biol. 147 (4), 891-903 (1999)
   PUBMED   10562289
REFERENCE   8  (bases 1 to 3452)
  AUTHORS   Swisshelm,K., Machl,A., Planitzer,S., Robertson,R., Kubbies,M. and
            Hosier,S.
  TITLE     SEMP1, a senescence-associated cDNA isolated from human mammary
            epithelial cells, is a member of an epithelial membrane protein
            superfamily
  JOURNAL   Gene 226 (2), 285-295 (1999)
   PUBMED   9931503
REFERENCE   9  (bases 1 to 3452)
  AUTHORS   Morita,K., Furuse,M., Fujimoto,K. and Tsukita,S.
  TITLE     Claudin multigene family encoding four-transmembrane domain protein
            components of tight junction strands
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 96 (2), 511-516 (1999)
   PUBMED   9892664
REFERENCE   10 (bases 1 to 3452)
  AUTHORS   Furuse,M., Fujita,K., Hiiragi,T., Fujimoto,K. and Tsukita,S.
  TITLE     Claudin-1 and -2: novel integral membrane proteins localizing at
            tight junctions with no sequence similarity to occludin
  JOURNAL   J. Cell Biol. 141 (7), 1539-1550 (1998)
   PUBMED   9647647
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA907275.1, AY358652.1 and
            AC009520.16.
            This sequence is a reference standard in the RefSeqGene project.
            On May 25, 2010 this sequence version replaced gi:21536297.
            
            Summary: Tight junctions represent one mode of cell-to-cell
            adhesion in epithelial or endothelial cell sheets, forming
            continuous seals around cells and serving as a physical barrier to
            prevent solutes and water from passing freely through the
            paracellular space. These junctions are comprised of sets of
            continuous networking strands in the outwardly facing cytoplasmic
            leaflet, with complementary grooves in the inwardly facing
            extracytoplasmic leaflet. The protein encoded by this gene, a
            member of the claudin family, is an integral membrane protein and a
            component of tight junction strands. Loss of function mutations
            result in neonatal ichthyosis-sclerosing cholangitis syndrome.
            [provided by RefSeq, Jul 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF101051.1, AY358652.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           ERS025084, ERS025085 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-228               DA907275.1         1-228
            229-1136            AY358652.1         207-1114
            1137-3452           AC009520.16        10690-13005         c
FEATURES             Location/Qualifiers
     source          1..3452
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q28-q29"
     gene            1..3452
                     /gene="CLDN1"
                     /gene_synonym="CLD1; ILVASC; SEMP1"
                     /note="claudin 1"
                     /db_xref="GeneID:9076"
                     /db_xref="HGNC:2032"
                     /db_xref="HPRD:04760"
                     /db_xref="MIM:603718"
     exon            1..463
                     /gene="CLDN1"
                     /gene_synonym="CLD1; ILVASC; SEMP1"
                     /inference="alignment:Splign:1.39.8"
     misc_feature    130..132
                     /gene="CLDN1"
                     /gene_synonym="CLD1; ILVASC; SEMP1"
                     /note="upstream in-frame stop codon"
     CDS             241..876
                     /gene="CLDN1"
                     /gene_synonym="CLD1; ILVASC; SEMP1"
                     /note="senescence-associated epithelial membrane protein
                     1"
                     /codon_start=1
                     /product="claudin-1"
                     /protein_id="NP_066924.1"
                     /db_xref="GI:10863887"
                     /db_xref="CCDS:CCDS3295.1"
                     /db_xref="GeneID:9076"
                     /db_xref="HGNC:2032"
                     /db_xref="HPRD:04760"
                     /db_xref="MIM:603718"
                     /translation="
MANAGLQLLGFILAFLGWIGAIVSTALPQWRIYSYAGDNIVTAQAMYEGLWMSCVSQSTGQIQCKVFDSLLNLSSTLQATRALMVVGILLGVIAIFVATVGMKCMKCLEDDEVQKMRMAVIGGAIFLLAGLAILVATAWYGNRIVQEFYDPMTPVNARYEFGQALFTGWAAASLCLLGGALLCCSCPRKTTSYPTPRPYPKPAPSSGKDYV
"
     misc_feature    253..747
                     /gene="CLDN1"
                     /gene_synonym="CLD1; ILVASC; SEMP1"
                     /note="PMP-22/EMP/MP20/Claudin family; Region:
                     PMP22_Claudin; cl15797"
                     /db_xref="CDD:210197"
     misc_feature    262..324
                     /gene="CLDN1"
                     /gene_synonym="CLD1; ILVASC; SEMP1"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (O95832.1);
                     transmembrane region"
     misc_feature    484..546
                     /gene="CLDN1"
                     /gene_synonym="CLD1; ILVASC; SEMP1"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (O95832.1);
                     transmembrane region"
     misc_feature    586..648
                     /gene="CLDN1"
                     /gene_synonym="CLD1; ILVASC; SEMP1"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (O95832.1);
                     transmembrane region"
     misc_feature    730..792
                     /gene="CLDN1"
                     /gene_synonym="CLD1; ILVASC; SEMP1"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (O95832.1);
                     transmembrane region"
     misc_feature    868..873
                     /gene="CLDN1"
                     /gene_synonym="CLD1; ILVASC; SEMP1"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (O95832.1);
                     Region: Interactions with TJP1, TJP2, TJP3 and INADL (By
                     similarity)"
     variation       348
                     /gene="CLDN1"
                     /gene_synonym="CLD1; ILVASC; SEMP1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:72466472"
     exon            464..628
                     /gene="CLDN1"
                     /gene_synonym="CLD1; ILVASC; SEMP1"
                     /inference="alignment:Splign:1.39.8"
     exon            629..713
                     /gene="CLDN1"
                     /gene_synonym="CLD1; ILVASC; SEMP1"
                     /inference="alignment:Splign:1.39.8"
     exon            714..3452
                     /gene="CLDN1"
                     /gene_synonym="CLD1; ILVASC; SEMP1"
                     /inference="alignment:Splign:1.39.8"
     variation       978
                     /gene="CLDN1"
                     /gene_synonym="CLD1; ILVASC; SEMP1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:3172404"
     variation       986
                     /gene="CLDN1"
                     /gene_synonym="CLD1; ILVASC; SEMP1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:3172403"
     variation       1137
                     /gene="CLDN1"
                     /gene_synonym="CLD1; ILVASC; SEMP1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:1043747"
     variation       2086
                     /gene="CLDN1"
                     /gene_synonym="CLD1; ILVASC; SEMP1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1060679"
     variation       2299
                     /gene="CLDN1"
                     /gene_synonym="CLD1; ILVASC; SEMP1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:1060680"
     variation       2754
                     /gene="CLDN1"
                     /gene_synonym="CLD1; ILVASC; SEMP1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:2204226"
     STS             3099..3394
                     /gene="CLDN1"
                     /gene_synonym="CLD1; ILVASC; SEMP1"
                     /standard_name="WI-19957"
                     /db_xref="UniSTS:78391"
     STS             3201..3351
                     /gene="CLDN1"
                     /gene_synonym="CLD1; ILVASC; SEMP1"
                     /standard_name="A001W08"
                     /db_xref="UniSTS:58726"
     STS             3201..3351
                     /gene="CLDN1"
                     /gene_synonym="CLD1; ILVASC; SEMP1"
                     /standard_name="G19705"
                     /db_xref="UniSTS:58725"
     STS             3339..3413
                     /gene="CLDN1"
                     /gene_synonym="CLD1; ILVASC; SEMP1"
                     /standard_name="G30141"
                     /db_xref="UniSTS:44945"
ORIGIN      
gtctcagttcccgagcctgggagcaaccgcagcttctagtatccagactccagcgccgccccgggcgcggaccccaaccccgacccagagcttctccagcggcggcgcagcgagcagggctccccgccttaacttcctccgcggggcccagccaccttcgggagtccgggttgcccacctgcaaactctccgccttctgcacctgccacccctgagccagcgcgggcgcccgagcgagtcatggccaacgcggggctgcagctgttgggcttcattctcgccttcctgggatggatcggcgccatcgtcagcactgccctgccccagtggaggatttactcctatgccggcgacaacatcgtgaccgcccaggccatgtacgaggggctgtggatgtcctgcgtgtcgcagagcaccgggcagatccagtgcaaagtctttgactccttgctgaatctgagcagcacattgcaagcaacccgtgccttgatggtggttggcatcctcctgggagtgatagcaatctttgtggccaccgttggcatgaagtgtatgaagtgcttggaagacgatgaggtgcagaagatgaggatggctgtcattgggggtgcgatatttcttcttgcaggtctggctattttagttgccacagcatggtatggcaatagaatcgttcaagaattctatgaccctatgaccccagtcaatgccaggtacgaatttggtcaggctctcttcactggctgggctgctgcttctctctgccttctgggaggtgccctactttgctgttcctgtccccgaaaaacaacctcttacccaacaccaaggccctatccaaaacctgcaccttccagcgggaaagactacgtgtgacacagaggcaaaaggagaaaatcatgttgaaacaaaccgaaaatggacattgagatactatcattaacattaggaccttagaattttgggtattgtaatctgaagtatggtattacaaaacaaacaaacaaacaaaaaacccatgtgttaaaatactcagtgctaaacatggcttaatcttattttatcttctttcctcaatataggagggaagatttttccatttgtattactgcttcccattgagtaatcatactcaactgggggaaggggtgctccttaaatatatatagatatgtatatatacatgtttttctattaaaaatagacagtaaaatactattctcattatgttgatactagcatacttaaaatatctctaaaataggtaaatgtatttaattccatattgatgaagatgtttattggtatattttctttttcgtctatatatacatatgtaacagtcaaatatcatttactcttcttcattagctttgggtgcctttgccacaagacctagcctaatttaccaaggatgaattctttcaattcttcatgcgtgcccttttcatatacttattttattttttaccataatcttatagcacttgcatcgttattaagcccttatttgttttgtgtttcattggtctctatctcctgaatctaacacatttcatagcctacattttagtttctaaagccaagaagaatttattacaaatcagaactttggaggcaaatctttctgcatgaccaaagtgataaattcctgttgaccttcccacacaatccctgtactctgacccatagcactcttgtttgctttgaaaatatttgtccaattgagtagctgcatgctgttcccccaggtgttgtaacacaactttattgattgaatttttaagctacttattcatagttttatatccccctaaactacctttttgttccccattccttaattgtattgttttcccaagtgtaattatcatgcgttttatatcttcctaataaggtgtggtctgtttgtctgaacaaagtgctagactttctggagtgataatctggtgacaaatattctctctgtagctgtaagcaagtcacttaatctttctacctcttttttctatctgccaaattgagataatgatacttaaccagttagaagaggtagtgtgaatattaattagtttatattactctcattctttgaacatgaactatgcctatgtagtgtctttatttgctcagctggctgagacactgaagaagtcactgaacaaaacctacacacgtaccttcatgtgattcactgccttcctctctctaccagtctatttccactgaacaaaacctacacacataccttcatgtggttcagtgccttcctctctctaccagtctatttccactgaacaaaacctacgcacataccttcatgtggctcagtgccttcctctctctaccagtctatttccattctttcagctgtgtctgacatgtttgtgctctgttccattttaacaactgctcttacttttccagtctgtacagaatgctatttcacttgagcaagatgatgtaatggaaagggtgttggcattggtgtctggagacctggatttgagtcttggtgctatcaatcaccgtctgtgtttgagcaaggcatttggctgctgtaagcttattgcttcatctgtaagcggtggtttgtaattcctgatcttcccacctcacagtgatgttgtggggatccagtgagatagaatacatgtaagtgtggttttgtaatttaaaaagtgctatactaagggaaagaattgaggaattaactgcatacgttttggtgttgcttttcaaatgtttgaaaacaaaaaaaatgttaagaaatgggtttcttgccttaaccagtctctcaagtgatgagacagtgaagtaaaattgagtgcactaaacaaataagattctgaggaagtcttatcttctgcagtgagtatggcccgatgctttctgtggctaaacagatgtaatgggaagaaataaaagcctacgtgttggtaaatccaacagcaagggagatttttgaatcataataactcataaggtgctatctgttcagtgatgccctcagagctcttgctgttagctggcagctgacgctgctaggatagttagtttggaaatggtacttcataataaactacacaaggaaagtcagccactgtgtcttatgaggaattggacctaataaattttagtgtgccttccaaacctgagaatatatgcttttggaagttaaaatttaaatggcttttgccacatacatagatcttcatgatgtgtgagtgtaattccatgtggatatcagttaccaaacattacaaaaaaattttatggcccaaaatgaccaacgaaattgttacaatagaatttatccaattttgatctttttatattcttctaccacacctggaaacagaccaatagacattttggggttttataataggaatttgtataaagcattactctttttcaataaattgttttttaatttaaaaaaaggatta
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:9076 -> Molecular function: GO:0005198 [structural molecule activity] evidence: IEA
            GeneID:9076 -> Molecular function: GO:0042802 [identical protein binding] evidence: ISS
            GeneID:9076 -> Biological process: GO:0007155 [cell adhesion] evidence: TAS
            GeneID:9076 -> Biological process: GO:0016338 [calcium-independent cell-cell adhesion] evidence: ISS
            GeneID:9076 -> Biological process: GO:0019048 [modulation by virus of host morphology or physiology] evidence: IEA
            GeneID:9076 -> Biological process: GO:0045216 [cell-cell junction organization] evidence: IMP
            GeneID:9076 -> Cellular component: GO:0005887 [integral to plasma membrane] evidence: TAS
            GeneID:9076 -> Cellular component: GO:0005923 [tight junction] evidence: ISS
            GeneID:9076 -> Cellular component: GO:0016021 [integral to membrane] evidence: TAS
            GeneID:9076 -> Cellular component: GO:0016324 [apical plasma membrane] evidence: IEA
            GeneID:9076 -> Cellular component: GO:0016328 [lateral plasma membrane] evidence: IEA

by @meso_cacase at DBCLS
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