GGRNA | NM_020856.2

LOCUS       NM_020856               4995 bp    mRNA    linear   PRI 17-APR-2013
DEFINITION  Homo sapiens teashirt zinc finger homeobox 3 (TSHZ3), mRNA.
ACCESSION   NM_020856
VERSION     NM_020856.2  GI:127138956
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4995)
  AUTHORS   Faralli,H., Martin,E., Core,N., Liu,Q.C., Filippi,P.,
            Dilworth,F.J., Caubit,X. and Fasano,L.
  TITLE     Teashirt-3, a novel regulator of muscle differentiation, associates
            with BRG1-associated factor 57 (BAF57) to inhibit myogenin gene
            expression
  JOURNAL   J. Biol. Chem. 286 (26), 23498-23510 (2011)
   PUBMED   21543328
REFERENCE   2  (bases 1 to 4995)
  AUTHORS   Lemaitre,R.N., Tanaka,T., Tang,W., Manichaikul,A., Foy,M.,
            Kabagambe,E.K., Nettleton,J.A., King,I.B., Weng,L.C.,
            Bhattacharya,S., Bandinelli,S., Bis,J.C., Rich,S.S., Jacobs,D.R.
            Jr., Cherubini,A., McKnight,B., Liang,S., Gu,X., Rice,K.,
            Laurie,C.C., Lumley,T., Browning,B.L., Psaty,B.M., Chen,Y.D.,
            Friedlander,Y., Djousse,L., Wu,J.H., Siscovick,D.S.,
            Uitterlinden,A.G., Arnett,D.K., Ferrucci,L., Fornage,M., Tsai,M.Y.,
            Mozaffarian,D. and Steffen,L.M.
  TITLE     Genetic loci associated with plasma phospholipid n-3 fatty acids: a
            meta-analysis of genome-wide association studies from the CHARGE
            Consortium
  JOURNAL   PLoS Genet. 7 (7), E1002193 (2011)
   PUBMED   21829377
REFERENCE   3  (bases 1 to 4995)
  AUTHORS   Yamamoto,M., Cid,E., Bru,S. and Yamamoto,F.
  TITLE     Rare and frequent promoter methylation, respectively, of TSHZ2 and
            3 genes that are both downregulated in expression in breast and
            prostate cancers
  JOURNAL   PLoS ONE 6 (3), E17149 (2011)
   PUBMED   21423795
  REMARK    GeneRIF: TSHZ3 gene promoter was found to be methylated in all the
            breast/prostate cancer cell lines and some of the breast cancer
            clinical specimens while the TSHZ2 gene promoter was unmethylated
            except for the MDA-MB-231 breast cancer cell line.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4995)
  AUTHORS   Jenkins,D., Caubit,X., Dimovski,A., Matevska,N., Lye,C.M.,
            Cabuk,F., Gucev,Z., Tasic,V., Fasano,L. and Woolf,A.S.
  TITLE     Analysis of TSHZ2 and TSHZ3 genes in congenital pelvi-ureteric
            junction obstruction
  JOURNAL   Nephrol. Dial. Transplant. 25 (1), 54-60 (2010)
   PUBMED   19745106
  REMARK    GeneRIF: Mutations in TSHZ2 and TSHZ3 are not a major cause of
            pelvi-ureteric junction obstruction, at least in Albanian and
            Macedonian populations.
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   5  (bases 1 to 4995)
  AUTHORS   Hendrickson,S.L., Lautenberger,J.A., Chinn,L.W., Malasky,M.,
            Sezgin,E., Kingsley,L.A., Goedert,J.J., Kirk,G.D., Gomperts,E.D.,
            Buchbinder,S.P., Troyer,J.L. and O'Brien,S.J.
  TITLE     Genetic variants in nuclear-encoded mitochondrial genes influence
            AIDS progression
  JOURNAL   PLoS ONE 5 (9), E12862 (2010)
   PUBMED   20877624
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4995)
  AUTHORS   Need,A.C., Attix,D.K., McEvoy,J.M., Cirulli,E.T., Linney,K.L.,
            Hunt,P., Ge,D., Heinzen,E.L., Maia,J.M., Shianna,K.V., Weale,M.E.,
            Cherkas,L.F., Clement,G., Spector,T.D., Gibson,G. and
            Goldstein,D.B.
  TITLE     A genome-wide study of common SNPs and CNVs in cognitive
            performance in the CANTAB
  JOURNAL   Hum. Mol. Genet. 18 (23), 4650-4661 (2009)
   PUBMED   19734545
REFERENCE   7  (bases 1 to 4995)
  AUTHORS   Kajiwara,Y., Akram,A., Katsel,P., Haroutunian,V., Schmeidler,J.,
            Beecham,G., Haines,J.L., Pericak-Vance,M.A. and Buxbaum,J.D.
  TITLE     FE65 binds Teashirt, inhibiting expression of the primate-specific
            caspase-4
  JOURNAL   PLoS ONE 4 (4), E5071 (2009)
   PUBMED   19343227
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AI015687.1, BX648745.1, CN256026.1 and AL136805.1.
            On Mar 9, 2007 this sequence version replaced gi:24308230.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DB289772.1, BX648745.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           ERS025081, ERS025084 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-46                AI015687.1         49-94
            47-754              BX648745.1         1-708
            755-1023            CN256026.1         477-745
            1024-4995           AL136805.1         436-4407
FEATURES             Location/Qualifiers
     source          1..4995
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q12"
     gene            1..4995
                     /gene="TSHZ3"
                     /gene_synonym="TSH3; ZNF537"
                     /note="teashirt zinc finger homeobox 3"
                     /db_xref="GeneID:57616"
                     /db_xref="HGNC:30700"
                     /db_xref="MIM:614119"
     exon            1..105
                     /gene="TSHZ3"
                     /gene_synonym="TSH3; ZNF537"
                     /inference="alignment:Splign:1.39.8"
     CDS             66..3311
                     /gene="TSHZ3"
                     /gene_synonym="TSH3; ZNF537"
                     /note="teashirt family zinc finger 3; zinc finger protein
                     537; teashirt 3"
                     /codon_start=1
                     /product="teashirt homolog 3"
                     /protein_id="NP_065907.2"
                     /db_xref="GI:127138957"
                     /db_xref="CCDS:CCDS12421.2"
                     /db_xref="GeneID:57616"
                     /db_xref="HGNC:30700"
                     /db_xref="MIM:614119"
                     /translation="

MPRRKQQAPRRAAAYVSEELKAAALVDEGLDPEEHTADGEPSAKYMCPEKELARACPSYQNSPAAEFSCHEMDSESHISETSDRMADFESGSIKNEEETKEVTVPLEDTTVSDSLEQMKAVYNNFLSNSYWSNLNLNLHQPSSEKNNGSSSSSSSSSSSCGSGSFDWHQSAMAKTLQQVSQSRMLPEPSLFSTVQLYRQSSKLYGSIFTGASKFRCKDCSAAYDTLVELTVHMNETGHYRDDNHETDNNNPKRWSKPRKRSLLEMEGKEDAQKVLKCMYCGHSFESLQDLSVHMIKTKHYQKVPLKEPVTPVAAKIIPATRKKASLELELPSSPDSTGGTPKATISDTNDALQKNSNPYITPNNRYGHQNGASYAWHFEARKSQILKCMECGSSHDTLQELTAHMMVTGHFIKVTNSAMKKGKPIVETPVTPTITTLLDEKVQSVPLAATTFTSPSNTPASISPKLNVEVKKEVDKEKAVTDEKPKQKDKPGEEEEKCDISSKYHYLTENDLEESPKGGLDILKSLENTVTSAINKAQNGTPSWGGYPSIHAAYQLPNMMKLSLGSSGKSTPLKPMFGNSEIVSPTKNQTLVSPPSSQTSPMPKTNFHAMEELVKKVTEKVAKVEEKMKEPDGKLSPPKRATPSPCSSEVGEPIKMEASSDGGFRSQENSPSPPRDGCKDGSPLAEPVENGKELVKPLASSLSGSTAIITDHPPEQPFVNPLSALQSVMNIHLGKAAKPSLPALDPMSMLFKMSNSLAEKAAVATPPPLQSKKADHLDRYFYHVNNDQPIDLTKGKSDKGCSLGSVLLSPTSTAPATSSSTVTTAKTSAVVSFMSNSPLRENALSDISDMLKNLTESHTSKSSTPSSISEKSDIDGATLEEAEESTPAQKRKGRQSNWNPQHLLILQAQFAASLRQTSEGKYIMSDLSPQERMHISRFTGLSMTTISHWLANVKYQLRRTGGTKFLKNLDTGHPVFFCNDCASQIRTPSTYISHLESHLGFRLRDLSKLSTEQINSQIAQTKSPSEKMVTSSPEEDLGTSYQCKLCNRTFASKHAVKLHLSKTHGKSPEDHLLYVSELEKQ

"
     misc_feature    2109..2111
                     /gene="TSHZ3"
                     /gene_synonym="TSH3; ZNF537"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (Q63HK5.2); phosphorylation site"
     misc_feature    2739..2948
                     /gene="TSHZ3"
                     /gene_synonym="TSH3; ZNF537"
                     /note="Homeodomain;  DNA binding domains involved in the
                     transcriptional regulation of key eukaryotic developmental
                     processes; may bind to DNA as monomers or as homo- and/or
                     heterodimers, in a sequence-specific manner; Region:
                     homeodomain; cd00086"
                     /db_xref="CDD:28970"
     misc_feature    order(2739..2753,2757..2759,2829..2831,2859..2861,
                     2898..2900,2904..2909,2916..2921,2925..2933,2937..2942)
                     /gene="TSHZ3"
                     /gene_synonym="TSH3; ZNF537"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:28970"
     misc_feature    order(2745..2747,2754..2756,2907..2909,2916..2921,
                     2928..2930)
                     /gene="TSHZ3"
                     /gene_synonym="TSH3; ZNF537"
                     /note="specific DNA base contacts [nucleotide binding];
                     other site"
                     /db_xref="CDD:28970"
     exon            106..4913
                     /gene="TSHZ3"
                     /gene_synonym="TSH3; ZNF537"
                     /inference="alignment:Splign:1.39.8"
     STS             450..595
                     /gene="TSHZ3"
                     /gene_synonym="TSH3; ZNF537"
                     /standard_name="CHLC.GCT2C12"
                     /db_xref="UniSTS:71483"
     variation       1886
                     /gene="TSHZ3"
                     /gene_synonym="TSH3; ZNF537"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:3745783"
     variation       2348
                     /gene="TSHZ3"
                     /gene_synonym="TSH3; ZNF537"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:3745784"
     STS             2420..2665
                     /gene="TSHZ3"
                     /gene_synonym="TSH3; ZNF537"
                     /standard_name="TSHZ3"
                     /db_xref="UniSTS:504460"
     STS             3535..3678
                     /gene="TSHZ3"
                     /gene_synonym="TSH3; ZNF537"
                     /standard_name="RH99014"
                     /db_xref="UniSTS:91398"
     STS             4263..4389
                     /gene="TSHZ3"
                     /gene_synonym="TSH3; ZNF537"
                     /standard_name="RH65085"
                     /db_xref="UniSTS:43693"
     STS             4627..4803
                     /gene="TSHZ3"
                     /gene_synonym="TSH3; ZNF537"
                     /standard_name="RH46365"
                     /db_xref="UniSTS:75091"
     variation       4707
                     /gene="TSHZ3"
                     /gene_synonym="TSH3; ZNF537"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1048011"
ORIGIN

tccctccctgtcctcagcccggcagcggcggcggcggcggcagtggcagtcgccggagaagcatcatgccgaggaggaagcagcaggcgccccggcgcgcagcagcctatgtttccgaagagttaaaggctgctgccctggtggacgaaggtttagacccagaggagcatacggcagatggagagccctcggccaagtacatgtgcccggagaaggagctcgccagggcctgccccagctaccagaactccccggccgccgagttttcctgccatgaaatggacagcgagtcacacatcagtgagaccagtgaccgaatggctgactttgaaagcggctccatcaagaacgaagaggagaccaaggaggtcacggtcccactggaagacacgactgtgtcggatagcctggagcagatgaaggccgtgtacaacaacttcctctccaactcctactggtccaacctcaacctcaacctgcaccagccctcctcggagaagaacaacggcagcagcagcagcagcagtagcagcagcagcagctgtggcagcgggagcttcgactggcaccagagcgccatggctaagacgctgcagcaggtgtcacagagccgcatgctcccggagcccagcctcttcagcaccgtgcagctgtaccggcagagcagcaagctctatggctccatcttcacgggggccagcaagttccgctgtaaggactgcagcgctgcctacgacaccctggtggagttgacggtgcacatgaacgagacggggcattaccgcgacgacaaccatgagaccgataacaacaaccccaagcgctggtccaagcctcgcaaacgctccttgctggaaatggaagggaaggaagacgcccagaaggtgctgaagtgcatgtactgtggccactcctttgagtccctgcaggatttgagtgtccatatgatcaaaacaaaacactaccaaaaagtgcctctgaaggaacccgtcactcctgtcgccgccaaaatcatccctgccactcggaagaaagcttccctggagctggagctccccagctccccagattccacaggtggaacccccaaagccaccatctcagacaccaacgatgcacttcagaagaactccaacccttacatcacgccaaataatcggtacggccaccagaatggggccagctatgcatggcactttgaggcccggaagtcgcagatcctgaagtgcatggagtgtgggagctcgcatgacaccctgcaggagctcactgcccacatgatggtcactggccacttcatcaaggtcaccaactctgctatgaaaaaggggaagcccattgtggagacgcctgtcacacctaccatcacaaccctgctggatgagaaggtccagtccgtgcccctggcagccaccaccttcacgtccccctccaatacacctgccagcatctccccaaaactgaatgtggaggtcaagaaggaagtcgacaaggagaaagcggtcactgacgagaaacctaagcaaaaagacaagcctggcgaagaagaggagaagtgtgacatctcttccaaataccattacttgactgaaaatgacttagaagagagtcccaagggggggcttgatatcctcaaatccttggaaaacacagtgacatccgcaatcaacaaggcccagaacggcactcctagctgggggggctatcccagcatccatgccgcctaccaacttcccaacatgatgaagttgtccctgggctcgtcggggaagagcacgcccctgaaacccatgtttggcaacagtgagattgtctccccgacgaaaaaccagaccctggtctctccacccagcagccagacgtcccccatgcccaagacaaactttcatgccatggaggagctggtgaaaaaggtcactgagaaagttgccaaagtggaggagaagatgaaggagccggatgggaagctttccccgcccaagcgggccactccctccccatgtagcagcgaagtcggggaacccatcaagatggaggcatccagcgatgggggcttccgcagccaggagaacagccccagccccccgcgggatgggtgcaaggatgggagccccctcgctgagccggtggagaatggcaaggagctggtgaagcccctagccagcagtttgagtggcagcacggccatcatcaccgaccacccgcctgaacagccttttgttaaccctttgagcgccctgcagtcagtcatgaacattcacctgggcaaggccgccaagccctccctgcctgccctggaccccatgagcatgcttttcaagatgagcaacagcctggcggagaaggctgctgtggccaccccgccgcccctgcagtccaagaaggcagaccacctcgaccgctatttctaccacgtcaacaacgaccagcccatagacttgacaaaagggaagagtgacaaaggctgctccttgggttcagtgcttctgtcacccacgtccacagccccggcaacctcctcatccacggtgacaacggcaaagacatctgccgtcgtatcattcatgtcaaactcgccgctacgcgagaatgccttgtcagatatatccgatatgctgaagaacttgacagagagccacacgtcaaaatcctccactccttccagcatctccgagaagtctgacattgacggggccactctggaggaggctgaggagtcgacgcccgcccagaagaggaagggccgccagtcaaactggaacccccagcacctcctgatcctccaggcccagtttgccgccagcctccggcagacctcagaagggaagtacatcatgtcagacctgagcccccaggagcggatgcatatctccaggttcaccgggctgtccatgaccaccatcagccactggctggccaacgtgaaataccagcttcgaaggacaggtggaacaaagttcctcaaaaacttggacactggccaccccgtcttcttttgtaacgattgtgcgtcccaaatcaggactccttccacgtacatcagtcacctagagtcacacttaggcttccggctacgggacttatccaaactgtccaccgaacagattaacagtcagatagcacaaaccaagtcaccgtcagaaaaaatggtgacgtcctcccccgaggaagacctggggacttcctatcagtgcaaactttgcaatcggacctttgccagcaagcacgctgttaaacttcaccttagcaaaacacacgggaaatctccggaagaccaccttctgtatgtctctgagttagagaagcagtagcatttgcttttgatagaaaggactgcagtttgctttgagggaaactgtggaaggcaccttcaggccccctctgacttgttgttcttggcacatgttcttattttaactgcagagaatcactctgggctggactgttttgtataactgtacagtgtttaatagaggtgcataatcagctgttgttactggtaaaatatgaaggttaaaatgcagtggtaagtgtttggaactttgtgtaaacgggatttagttgtgagcatcctcccgatgcttcaagctgcatgcattaacagacagtttaattaagcatttataacggaatcaggcacaccttttccacgagactcgagtgtgctggcatttctcaccctttcatctttagccctctgagtactttgaagcacttttgcattaatttggttaaaaaataaaataaaataataataatgtatgaagctctgttttttaaactccttaccagcttagttataatgaataatatgaacctccatttatgcaggtctgcaggggtataacacgccttgaaatttaaaagaatattattttcacattgaaacatagatgtatatattgtatagatttcagactctcttatgaaaaaaaatgtgattgtggttaaatgacctttttcttgcatttatagcaacagtgttttatgcacctgctatgctctgggcataagctgtgcctatgtatagtgtatatttctttttttcttttttttaaggtctatgggttttgttttttacatgcaaacattgtaaattatacagaagataccacagatagcatttataaagtatacagaaacattatctgaaagcaaagtatgatagtttgttttgctatacagtacatctatattgatagaggttcatgtttaaattatacatatttattagcatcatattgtcatttgttttgagcagtctgaataaacgagaccgggaaagacatccctggcaggcatcagaactattttgcacatgatttttaaaggtatttattagaaatcaaagaacactcaaaataaactcagtgctcaaagggttaagtctatttgaaaaggttaaaaaaaagaacaaaaaaaaaaaaagaacttgtactgtatttcctaaacattgataaagcctttaaaatgtttgtactgtaatactttgcttaaaagtcatgaggcattctgtgatccaacctctttcacttatttataagccctcttggttgctattccatattgtaggatgcctttctatttcaattggtaactttctgttttgttcttcctaattattctcccaagatcccacactgcagctttatctttaggcttatgaaaggtaacccgtggttaccggctctccaagtgattctgttcttctccatttttggcagttaatttgcagaagtaactgacagctgacaccatatgagaacctttgtataaaatattggcatgtaaacagcacagacaccgtaacacactctgtgccctgtttggttgttgacaatgaagcaccattatgtgactcttcatataacccttttttctacggcagcattaaaattgtctttttgctataaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa

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