LOCUS       NM_020160               2166 bp    mRNA    linear   PRI 17-APR-2013
DEFINITION  Homo sapiens Meis homeobox 3 (MEIS3), transcript variant 1, mRNA.
ACCESSION   NM_020160
VERSION     NM_020160.2  GI:385137117
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2166)
  AUTHORS   Hyman-Walsh,C., Bjerke,G.A. and Wotton,D.
  TITLE     An autoinhibitory effect of the homothorax domain of Meis2
  JOURNAL   FEBS J. 277 (12), 2584-2597 (2010)
   PUBMED   20553494
  REMARK    GeneRIF: This work suggests that the transcriptional activity of
            all members of the Meis/Prep Hth protein family is subject to
            autoinhibition by their Hth domains, and that the Meis3.2 splice
            variant encodes a protein that bypasses this autoinhibitory effect.
REFERENCE   2  (bases 1 to 2166)
  AUTHORS   Shim,S., Kim,Y., Shin,J., Kim,J. and Park,S.
  TITLE     Regulation of EphA8 gene expression by TALE homeobox transcription
            factors during development of the mesencephalon
  JOURNAL   Mol. Cell. Biol. 27 (5), 1614-1630 (2007)
   PUBMED   17178831
REFERENCE   3  (bases 1 to 2166)
  AUTHORS   Steelman,S., Moskow,J.J., Muzynski,K., North,C., Druck,T.,
            Montgomery,J.C., Huebner,K., Daar,I.O. and Buchberg,A.M.
  TITLE     Identification of a conserved family of Meis1-related homeobox
            genes
  JOURNAL   Genome Res. 7 (2), 142-156 (1997)
   PUBMED   9049632
REFERENCE   4  (bases 1 to 2166)
  AUTHORS   Nakamura,T., Jenkins,N.A. and Copeland,N.G.
  TITLE     Identification of a new family of Pbx-related homeobox genes
  JOURNAL   Oncogene 13 (10), 2235-2242 (1996)
   PUBMED   8950991
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CF993984.1, AL537583.3, BC025404.1 and DB545063.1.
            On Apr 21, 2012 this sequence version replaced gi:57863280.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC025404.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           ERS025081, ERS025082 [ECO:0000350]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-359               CF993984.1         27-385
            360-360             AL537583.3         101-101
            361-2158            BC025404.1         124-1921
            2159-2166           DB545063.1         449-456
FEATURES             Location/Qualifiers
     source          1..2166
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.32"
     gene            1..2166
                     /gene="MEIS3"
                     /gene_synonym="MRG2"
                     /note="Meis homeobox 3"
                     /db_xref="GeneID:56917"
                     /db_xref="HGNC:29537"
                     /db_xref="HPRD:14386"
     exon            1..459
                     /gene="MEIS3"
                     /gene_synonym="MRG2"
                     /inference="alignment:Splign:1.39.8"
     misc_feature    229..231
                     /gene="MEIS3"
                     /gene_synonym="MRG2"
                     /note="upstream in-frame stop codon"
     CDS             448..1713
                     /gene="MEIS3"
                     /gene_synonym="MRG2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     homeobox protein Meis3; meis1-related protein 2; Meis1,
                     myeloid ecotropic viral integration site 1 homolog 3"
                     /codon_start=1
                     /product="homeobox protein Meis3 isoform 1"
                     /protein_id="NP_064545.1"
                     /db_xref="GI:57863281"
                     /db_xref="CCDS:CCDS33064.1"
                     /db_xref="GeneID:56917"
                     /db_xref="HGNC:29537"
                     /db_xref="HPRD:14386"
                     /translation="

MARRYDELPHYPGIVDGPAALASFPETVPAVPGPYGPHRPPQPLPPGLDSDGLKREKDEIYGHPLFPLLALVFEKCELATCSPRDGAGAGLGTPPGGDVCSSDSFNEDIAAFAKQVRSERPLFSSNPELDNLMIQAIQVLRFHLLELEKVHDLCDNFCHRYITCLKGKMPIDLVIEDRDGGCREDFEDYPASCPSLPDQNNMWIRDHEDSGSVHLGTPGPSSGGLASQSGDNSSDQGDGLDTSVASPSSGGEDEDLDQERRRNKKRGIFPKVATNIMRAWLFQHLSRRSEAPVLPDVCLGLGSPSPGPRWARPWGSDCGRPGRQSDSCWWLQHPYPSEEQKKQLAQDTGLTILQVNNWFINARRRIVQPMIDQSNRTGQGAAFSPEGQPIGGYTETQPHVAVRPPGSVGMSLNLEGEWHYL

"
     misc_feature    <1432..1542
                     /gene="MEIS3"
                     /gene_synonym="MRG2"
                     /note="Homeodomain;  DNA binding domains involved in the
                     transcriptional regulation of key eukaryotic developmental
                     processes; may bind to DNA as monomers or as homo- and/or
                     heterodimers, in a sequence-specific manner; Region:
                     homeodomain; cd00086"
                     /db_xref="CDD:28970"
     misc_feature    order(1450..1452,1468..1470,1507..1509,1513..1518,
                     1525..1530,1534..1542)
                     /gene="MEIS3"
                     /gene_synonym="MRG2"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:28970"
     misc_feature    order(1516..1518,1525..1530,1537..1539)
                     /gene="MEIS3"
                     /gene_synonym="MRG2"
                     /note="specific DNA base contacts [nucleotide binding];
                     other site"
                     /db_xref="CDD:28970"
     exon            460..632
                     /gene="MEIS3"
                     /gene_synonym="MRG2"
                     /inference="alignment:Splign:1.39.8"
     exon            633..792
                     /gene="MEIS3"
                     /gene_synonym="MRG2"
                     /inference="alignment:Splign:1.39.8"
     exon            793..843
                     /gene="MEIS3"
                     /gene_synonym="MRG2"
                     /inference="alignment:Splign:1.39.8"
     exon            844..894
                     /gene="MEIS3"
                     /gene_synonym="MRG2"
                     /inference="alignment:Splign:1.39.8"
     exon            895..1044
                     /gene="MEIS3"
                     /gene_synonym="MRG2"
                     /inference="alignment:Splign:1.39.8"
     exon            1045..1156
                     /gene="MEIS3"
                     /gene_synonym="MRG2"
                     /inference="alignment:Splign:1.39.8"
     exon            1157..1305
                     /gene="MEIS3"
                     /gene_synonym="MRG2"
                     /inference="alignment:Splign:1.39.8"
     exon            1306..1520
                     /gene="MEIS3"
                     /gene_synonym="MRG2"
                     /inference="alignment:Splign:1.39.8"
     exon            1521..1579
                     /gene="MEIS3"
                     /gene_synonym="MRG2"
                     /inference="alignment:Splign:1.39.8"
     exon            1580..1663
                     /gene="MEIS3"
                     /gene_synonym="MRG2"
                     /inference="alignment:Splign:1.39.8"
     exon            1664..1730
                     /gene="MEIS3"
                     /gene_synonym="MRG2"
                     /inference="alignment:Splign:1.39.8"
     STS             1707..1945
                     /gene="MEIS3"
                     /gene_synonym="MRG2"
                     /standard_name="RH80845"
                     /db_xref="UniSTS:91107"
     exon            1731..2166
                     /gene="MEIS3"
                     /gene_synonym="MRG2"
                     /inference="alignment:Splign:1.39.8"
     variation       1802
                     /gene="MEIS3"
                     /gene_synonym="MRG2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:14163"
     variation       1819
                     /gene="MEIS3"
                     /gene_synonym="MRG2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11622"
     variation       1830
                     /gene="MEIS3"
                     /gene_synonym="MRG2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:12620"
     variation       1878
                     /gene="MEIS3"
                     /gene_synonym="MRG2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1054120"
     variation       1992
                     /gene="MEIS3"
                     /gene_synonym="MRG2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1054126"
     variation       2105
                     /gene="MEIS3"
                     /gene_synonym="MRG2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1054128"
     polyA_site      2160
                     /gene="MEIS3"
                     /gene_synonym="MRG2"
ORIGIN      

ggagagaccgggaacggggagcgcggctgccagcacccctgagccgccgccggaccctccgtcgccccgggccgccccccgccccctgcggtccccggtgtgtccgtctcgggacggttcgattccctccagagccggggaagggacggggggggcccagaggagggggcctcgggcgccccgcctgcgcctgctgcccccgccccggcggcgatgcgctcctggccgtgacccccgctgggggcgggggccggggtccatgcgcggagtccccacccggcccggcgcctgccgctgacggcggcgggggtgggggggcgcgcgcctggcctcctgcccaccccctggcgtcaacaccgcgggccgtcaggggctgcggccccgggctgcgccctcccccgcggccaggctctggagggacccaggagctgccgccggcctcagcccatggcccggaggtatgatgagctgccgcactacccaggcatcgtggatggccccgcagccctggctagcttcccagagacagtgcccgcagtaccagggccctatggcccgcaccggcctccccagcccctgcccccaggcttggacagcgacggcctgaagagggagaaggatgagatctatggacacccgctcttccccctcttggccctggtctttgagaaatgtgaactggctacatgctctccccgtgacggggccggagctgggctggggacaccccctggaggtgacgtctgctcctctgattccttcaacgaggacatcgctgcctttgccaagcaggttcgctctgagaggcccctcttctcctccaacccagaactggacaatctgatgatccaggccatccaggtgctgcggttccacctgctggagctggagaaggtccacgacctgtgcgacaacttctgtcaccgctacatcacctgcctcaagggaaagatgcccatcgacctggtcatcgaggatcgggacggcggctgcagggaggacttcgaggactacccagcctcctgccccagcctcccagaccagaataatatgtggattcgagaccatgaggatagtgggtctgtacatttggggaccccaggtccatccagtgggggcctggcctcccagagtggggacaactccagtgaccaaggagacgggctggacaccagcgtggcctctcccagttctggtggagaagatgaggacttggaccaggagcgacggcgaaacaagaagagggggatcttccccaaggtggccaccaacatcatgcgagcctggttgttccagcacctctcgagacgctcagaagcgccggttctcccagacgtctgcctgggcctgggctccccatcccccggaccccggtgggccagaccttggggttcagactgcggccggccaggcaggcagagtgactcttgctggtggctgcagcacccgtacccctcggaggagcagaagaaacagctggcgcaggacacggggctcaccatcctgcaagtcaacaactggttcattaacgcccggagacgcatcgtgcaacctatgatcgatcaatccaaccgcacagggcagggtgcagccttcagcccagagggccagcccatcgggggctataccgagacgcagccacacgtggccgtccggcctccgggatcagtggggatgagtttgaacttggaaggagaatggcattatctatagaggctgatgcaggagagacccagcctccggctgtgacccccagcctcacacctgcctctggttcccgcctggtcctccagcttcaggaccccacctccaaaggcccctctgctcaatgcctacctccctagggccctgctgggacatgggggcctgagtgcccatccaagggctctcaaggacaccggcaaggcctccaggccctgagccccacttctgccttcacctctgcctgggacccgagctgggctcctgggccttggtccccagaagatggcggctagggcctcgccgccaggacagagaagggacggggtggctgggcagtcagggaaggagggtcgcccggatccgacattttggagagattccttcactctcctgtcccccctacctcccttctctaatttcttcttttttttaatgataaagtcttaaaaacacggagccacc

//

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:56917 -> Molecular function: GO:0001077 [RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription] evidence: IEA
            GeneID:56917 -> Molecular function: GO:0003682 [chromatin binding] evidence: IEA
            GeneID:56917 -> Molecular function: GO:0043565 [sequence-specific DNA binding] evidence: IDA
            GeneID:56917 -> Biological process: GO:0043066 [negative regulation of apoptotic process] evidence: IEA
            GeneID:56917 -> Biological process: GO:0051897 [positive regulation of protein kinase B signaling cascade] evidence: IEA
            GeneID:56917 -> Cellular component: GO:0005634 [nucleus] evidence: IEA