LOCUS       NM_019102               1657 bp    mRNA    linear   PRI 15-JUL-2013
DEFINITION  Homo sapiens homeobox A5 (HOXA5), mRNA.
ACCESSION   NM_019102
VERSION     NM_019102.3  GI:324073512
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1657)
  AUTHORS   Liang,Y., Xia,L., Du,Z., Sheng,L., Chen,H., Chen,G. and Li,Q.
  TITLE     HOXA5 inhibits keratinocytes growth and epidermal formation in
            organotypic cultures in vitro and in vivo
  JOURNAL   J. Dermatol. Sci. 66 (3), 197-206 (2012)
   PUBMED   22464764
  REMARK    GeneRIF: HOXA5 can suppress keratinocytes growth and epidermal
            formation.
REFERENCE   2  (bases 1 to 1657)
  AUTHORS   Rodini CO, Xavier FC, Paiva KB, De Souza Setubal Destro MF, Moyses
            RA, Michaluarte P, Carvalho MB, Fukuyama EE, Tajara EH, Okamoto OK
            and Nunes FD.
  CONSRTM   Head And Neck Genome Project Gencapo
  TITLE     Homeobox gene expression profile indicates HOXA5 as a candidate
            prognostic marker in oral squamous cell carcinoma
  JOURNAL   Int. J. Oncol. 40 (4), 1180-1188 (2012)
   PUBMED   22227861
  REMARK    GeneRIF: since lower levels of HOXA5 predict poor prognosis, this
            gene may be a novel candidate for development of therapeutic
            strategies in OSCC.
REFERENCE   3  (bases 1 to 1657)
  AUTHORS   Liu,X.H., Lu,K.H., Wang,K.M., Sun,M., Zhang,E.B., Yang,J.S.,
            Yin,D.D., Liu,Z.L., Zhou,J., Liu,Z.J., De,W. and Wang,Z.X.
  TITLE     MicroRNA-196a promotes non-small cell lung cancer cell
            proliferation and invasion through targeting HOXA5
  JOURNAL   BMC Cancer 12, 348 (2012)
   PUBMED   22876840
  REMARK    GeneRIF: Our analysis showed that miR-196a suppressed the
            expression of HOXA5 both at the mRNA and protein levels; knockdown
            of HOXA5 expression in A549 cells using RNAi was shown to promote
            NSCLC cell proliferation, migration and invasion.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1657)
  AUTHORS   Gray,S., Pandha,H.S., Michael,A., Middleton,G. and Morgan,R.
  TITLE     HOX genes in pancreatic development and cancer
  JOURNAL   JOP 12 (3), 216-219 (2011)
   PUBMED   21546695
  REMARK    GeneRIF: Studies suggest that HOXA4, HOXA5 and HOXB4 provide the
            spatial information needed to restrict the response to signals from
            the notochord, and not up regulated in pancreatic cancer.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1657)
  AUTHORS   Bens,S., Ammerpohl,O., Martin-Subero,J.I., Appari,M., Richter,J.,
            Hiort,O., Werner,R., Riepe,F.G., Siebert,R. and Holterhus,P.M.
  TITLE     Androgen receptor mutations are associated with altered epigenomic
            programming as evidenced by HOXA5 methylation
  JOURNAL   Sex Dev 5 (2), 70-76 (2011)
   PUBMED   21311178
  REMARK    GeneRIF: Androgen receptor mutations are associated with altered
            epigenomic programming as evidenced by HOXA5 methylation.
REFERENCE   6  (bases 1 to 1657)
  AUTHORS   Miano,J.M., Firulli,A.B., Olson,E.N., Hara,P., Giachelli,C.M. and
            Schwartz,S.M.
  TITLE     Restricted expression of homeobox genes distinguishes fetal from
            adult human smooth muscle cells
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 93 (2), 900-905 (1996)
   PUBMED   8570656
REFERENCE   7  (bases 1 to 1657)
  AUTHORS   Scott,M.P.
  TITLE     Vertebrate homeobox gene nomenclature
  JOURNAL   Cell 71 (4), 551-553 (1992)
   PUBMED   1358459
REFERENCE   8  (bases 1 to 1657)
  AUTHORS   McAlpine,P.J. and Shows,T.B.
  TITLE     Nomenclature for human homeobox genes
  JOURNAL   Genomics 7 (3), 460 (1990)
   PUBMED   1973146
REFERENCE   9  (bases 1 to 1657)
  AUTHORS   Tournier-Lasserve,E., Odenwald,W.F., Garbern,J., Trojanowski,J. and
            Lazzarini,R.A.
  TITLE     Remarkable intron and exon sequence conservation in human and mouse
            homeobox Hox 1.3 genes
  JOURNAL   Mol. Cell. Biol. 9 (5), 2273-2278 (1989)
   PUBMED   2568583
REFERENCE   10 (bases 1 to 1657)
  AUTHORS   Boncinelli,E., Acampora,D., Pannese,M., D'Esposito,M., Somma,R.,
            Gaudino,G., Stornaiuolo,A., Cafiero,M., Faiella,A. and Simeone,A.
  TITLE     Organization of human class I homeobox genes
  JOURNAL   Genome 31 (2), 745-756 (1989)
   PUBMED   2576652
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BI822268.1, BC013682.1 and
            AC004080.2.
            On Feb 25, 2011 this sequence version replaced gi:24497516.
            
            Summary: In vertebrates, the genes encoding the class of
            transcription factors called homeobox genes are found in clusters
            named A, B, C, and D on four separate chromosomes. Expression of
            these proteins is spatially and temporally regulated during
            embryonic development. This gene is part of the A cluster on
            chromosome 7 and encodes a DNA-binding transcription factor which
            may regulate gene expression, morphogenesis, and differentiation.
            Methylation of this gene may result in the loss of its expression
            and, since the encoded protein upregulates the tumor suppressor
            p53, this protein may play an important role in tumorigenesis.
            [provided by RefSeq, Jul 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BI822268.1, BC013682.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           ERS025081, ERS025084 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                BI822268.1         1-13
            14-1165             BC013682.1         1-1152
            1166-1657           AC004080.2         14422-14913         c
FEATURES             Location/Qualifiers
     source          1..1657
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p15.2"
     gene            1..1657
                     /gene="HOXA5"
                     /gene_synonym="HOX1; HOX1.3; HOX1C"
                     /note="homeobox A5"
                     /db_xref="GeneID:3202"
                     /db_xref="HGNC:5106"
                     /db_xref="HPRD:00840"
                     /db_xref="MIM:142952"
     exon            1..623
                     /gene="HOXA5"
                     /gene_synonym="HOX1; HOX1.3; HOX1C"
                     /inference="alignment:Splign:1.39.8"
     CDS             62..874
                     /gene="HOXA5"
                     /gene_synonym="HOX1; HOX1.3; HOX1C"
                     /note="homeo box A5; homeo box 1C; homeobox protein HOXA5;
                     homeobox protein Hox-1C"
                     /codon_start=1
                     /product="homeobox protein Hox-A5"
                     /protein_id="NP_061975.2"
                     /db_xref="GI:24497517"
                     /db_xref="CCDS:CCDS5406.1"
                     /db_xref="GeneID:3202"
                     /db_xref="HGNC:5106"
                     /db_xref="HPRD:00840"
                     /db_xref="MIM:142952"
                     /translation="

MSSYFVNSFCGRYPNGPDYQLHNYGDHSSVSEQFRDSASMHSGRYGYGYNGMDLSVGRSGSGHFGSGERARSYAASASAAPAEPRYSQPATSTHSPQPDPLPCSAVAPSPGSDSHHGGKNSLSNSSGASADAGSTHISSREGVGTASGAEEDAPASSEQASAQSEPSPAPPAQPQIYPWMRKLHISHDNIGGPEGKRARTAYTRYQTLELEKEFHFNRYLTRRRRIEIAHALCLSERQIKIWFQNRRMKWKKDNKLKSMSMAAAGGAFRP

"
     misc_feature    587..604
                     /gene="HOXA5"
                     /gene_synonym="HOX1; HOX1.3; HOX1C"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P20719.2);
                     Region: Antp-type hexapeptide"
     misc_feature    647..823
                     /gene="HOXA5"
                     /gene_synonym="HOX1; HOX1.3; HOX1C"
                     /note="Homeodomain;  DNA binding domains involved in the
                     transcriptional regulation of key eukaryotic developmental
                     processes; may bind to DNA as monomers or as homo- and/or
                     heterodimers, in a sequence-specific manner; Region:
                     homeodomain; cd00086"
                     /db_xref="CDD:28970"
     misc_feature    order(647..661,665..667,716..718,734..736,773..775,
                     779..784,791..796,800..808,812..817)
                     /gene="HOXA5"
                     /gene_synonym="HOX1; HOX1.3; HOX1C"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:28970"
     misc_feature    order(653..655,662..664,782..784,791..796,803..805)
                     /gene="HOXA5"
                     /gene_synonym="HOX1; HOX1.3; HOX1C"
                     /note="specific DNA base contacts [nucleotide binding];
                     other site"
                     /db_xref="CDD:28970"
     STS             109..353
                     /gene="HOXA5"
                     /gene_synonym="HOX1; HOX1.3; HOX1C"
                     /standard_name="REN100521"
                     /db_xref="UniSTS:425318"
     STS             142..226
                     /gene="HOXA5"
                     /gene_synonym="HOX1; HOX1.3; HOX1C"
                     /standard_name="Hoxa5"
                     /db_xref="UniSTS:536643"
     variation       286
                     /gene="HOXA5"
                     /gene_synonym="HOX1; HOX1.3; HOX1C"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:1047218"
     STS             342..596
                     /gene="HOXA5"
                     /gene_synonym="HOX1; HOX1.3; HOX1C"
                     /standard_name="REN100520"
                     /db_xref="UniSTS:425317"
     exon            624..1657
                     /gene="HOXA5"
                     /gene_synonym="HOX1; HOX1.3; HOX1C"
                     /inference="alignment:Splign:1.39.8"
     STS             684..1553
                     /gene="HOXA5"
                     /gene_synonym="HOX1; HOX1.3; HOX1C"
                     /standard_name="ECD01324"
                     /db_xref="UniSTS:282430"
     STS             694..1515
                     /gene="HOXA5"
                     /gene_synonym="HOX1; HOX1.3; HOX1C"
                     /standard_name="HOXA5_3307"
                     /db_xref="UniSTS:462253"
     STS             703..853
                     /gene="HOXA5"
                     /gene_synonym="HOX1; HOX1.3; HOX1C"
                     /standard_name="Hoxa5"
                     /db_xref="UniSTS:239193"
     STS             818..1077
                     /gene="HOXA5"
                     /gene_synonym="HOX1; HOX1.3; HOX1C"
                     /standard_name="REN100513"
                     /db_xref="UniSTS:425310"
     variation       912
                     /gene="HOXA5"
                     /gene_synonym="HOX1; HOX1.3; HOX1C"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:1047290"
     STS             968..1293
                     /gene="HOXA5"
                     /gene_synonym="HOX1; HOX1.3; HOX1C"
                     /standard_name="UniSTS:57649"
                     /db_xref="UniSTS:57649"
     STS             1054..1291
                     /gene="HOXA5"
                     /gene_synonym="HOX1; HOX1.3; HOX1C"
                     /standard_name="REN100512"
                     /db_xref="UniSTS:425309"
     variation       1166
                     /gene="HOXA5"
                     /gene_synonym="HOX1; HOX1.3; HOX1C"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1047294"
     STS             1214..1507
                     /gene="HOXA5"
                     /gene_synonym="HOX1; HOX1.3; HOX1C"
                     /standard_name="Hoxa5"
                     /db_xref="UniSTS:265255"
     STS             1255..1468
                     /gene="HOXA5"
                     /gene_synonym="HOX1; HOX1.3; HOX1C"
                     /standard_name="stSG609349"
                     /db_xref="UniSTS:449442"
     STS             1277..1547
                     /gene="HOXA5"
                     /gene_synonym="HOX1; HOX1.3; HOX1C"
                     /standard_name="REN100511"
                     /db_xref="UniSTS:425308"
     STS             1416..1564
                     /gene="HOXA5"
                     /gene_synonym="HOX1; HOX1.3; HOX1C"
                     /standard_name="Hoxa5"
                     /db_xref="UniSTS:143368"
     polyA_signal    1635..1640
                     /gene="HOXA5"
                     /gene_synonym="HOX1; HOX1.3; HOX1C"
     polyA_site      1657
                     /gene="HOXA5"
                     /gene_synonym="HOX1; HOX1.3; HOX1C"
ORIGIN      

gggtgctatagacgcacaaacgaccgcgagccacaaatcaagcacacatatcaaaaaacaaatgagctcttattttgtaaactcattttgcggtcgctatccaaatggcccggactaccagttgcataattatggagatcatagttccgtgagcgagcaattcagggactcggcgagcatgcactccggcaggtacggctacggctacaatggcatggatctcagcgtcggccgctcgggctccggccactttggctccggagagcgcgcccgcagctacgctgccagcgccagcgcggcgcccgccgagcccaggtacagccagccggccacgtccacgcactctcctcagcccgatccgctgccctgctccgccgtggccccctcgcccggcagcgacagccaccacggcgggaaaaactccctaagcaactccagcggcgcctcggccgacgccggcagcacccacatcagcagcagagagggggttggcacggcgtccggagccgaggaggacgcccctgccagcagcgagcaggcgagtgcgcagagcgagccgagcccggcgccgcccgcccaaccccagatctacccctggatgcgcaagctgcacataagtcatgacaacataggcggcccggaaggcaaaagggcccggacggcctacacgcgctaccagaccctggagctggagaaggagttccacttcaaccgttacctgacccgcagaaggaggattgaaatagcacatgctctttgcctctccgagagacaaattaaaatctggttccaaaaccggagaatgaagtggaaaaaagataataagctgaaaagcatgagcatggccgcggcaggaggggccttccgtccctgagtatctgagcgtttaaagtactgagcagtattagcggatcccgcgtagtgtcagtactaaggtgactttctgaaactcccttgtgttccttctgtgaagaagccctgttctcgttgccctaattcatcttttaatcatgagcctgtttattgccattatagcgcctgtataagtagatctgctttctgttcatctctttgtcctgaatggctttgtcttgaaaaaaaatagatgttttaacttatttatatgaagcaagctgtgttacttgaagtaactataacaaaaaaagaaaagagaaaaaaaaacacacaaaaagtcccccttcaatctcgtttagtgccaatgttgtgtgttgcactcaagttgtttaactgtgcatgtgcgtggaagtgttcctgtctcaatagctccaagctgttaaagatatttttattcaaactacctatattccttgtgtaattaatgctgttgtagaggtgacttgatgagacacaacttgttcgacgtgtagtgactagtgactctgtgatgaaaactgtgactccaagcggtgtgtccctgcgtgcctttataggaccctttgcacgaactctggaagtggctcttataagcgcagcttcagtgatgtatgtttttgtgaacaaagttacaaatattgtccaagtctggctgttttaagcaaactgtgatcagcttttttttttttttttttttttttgtatttgtttttaaggaaaaaatactgactggaacaaaaaataaactttctattgtaagttc

//

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:3202 -> Molecular function: GO:0003677 [DNA binding] evidence: IDA
            GeneID:3202 -> Molecular function: GO:0003700 [sequence-specific DNA binding transcription factor activity] evidence: IDA
            GeneID:3202 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
            GeneID:3202 -> Molecular function: GO:0043565 [sequence-specific DNA binding] evidence: IEA
            GeneID:3202 -> Biological process: GO:0003016 [respiratory system process] evidence: IEA
            GeneID:3202 -> Biological process: GO:0006351 [transcription, DNA-dependent] evidence: IEA
            GeneID:3202 -> Biological process: GO:0009952 [anterior/posterior pattern specification] evidence: IEA
            GeneID:3202 -> Biological process: GO:0010870 [positive regulation of receptor biosynthetic process] evidence: IDA
            GeneID:3202 -> Biological process: GO:0016477 [cell migration] evidence: IEA
            GeneID:3202 -> Biological process: GO:0016525 [negative regulation of angiogenesis] evidence: IMP
            GeneID:3202 -> Biological process: GO:0030878 [thyroid gland development] evidence: IEA
            GeneID:3202 -> Biological process: GO:0033599 [regulation of mammary gland epithelial cell proliferation] evidence: IEA
            GeneID:3202 -> Biological process: GO:0035264 [multicellular organism growth] evidence: IEA
            GeneID:3202 -> Biological process: GO:0043065 [positive regulation of apoptotic process] evidence: IDA
            GeneID:3202 -> Biological process: GO:0045639 [positive regulation of myeloid cell differentiation] evidence: IDA
            GeneID:3202 -> Biological process: GO:0045647 [negative regulation of erythrocyte differentiation] evidence: IDA
            GeneID:3202 -> Biological process: GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] evidence: IDA
            GeneID:3202 -> Biological process: GO:0048286 [lung alveolus development] evidence: IEA
            GeneID:3202 -> Biological process: GO:0048704 [embryonic skeletal system morphogenesis] evidence: IEA
            GeneID:3202 -> Biological process: GO:0060435 [bronchiole development] evidence: IEA
            GeneID:3202 -> Biological process: GO:0060441 [epithelial tube branching involved in lung morphogenesis] evidence: IEA
            GeneID:3202 -> Biological process: GO:0060480 [lung goblet cell differentiation] evidence: IEA
            GeneID:3202 -> Biological process: GO:0060484 [lung-associated mesenchyme development] evidence: IEA
            GeneID:3202 -> Biological process: GO:0060535 [trachea cartilage morphogenesis] evidence: IEA
            GeneID:3202 -> Biological process: GO:0060574 [intestinal epithelial cell maturation] evidence: IEA
            GeneID:3202 -> Biological process: GO:0060638 [mesenchymal-epithelial cell signaling] evidence: IEA
            GeneID:3202 -> Biological process: GO:0060644 [mammary gland epithelial cell differentiation] evidence: IEA
            GeneID:3202 -> Biological process: GO:0060749 [mammary gland alveolus development] evidence: IEA
            GeneID:3202 -> Biological process: GO:0060764 [cell-cell signaling involved in mammary gland development] evidence: IEA
            GeneID:3202 -> Cellular component: GO:0005634 [nucleus] evidence: IDA