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2024-04-26 06:10:45, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_018271 1985 bp mRNA linear PRI 20-APR-2013
DEFINITION Homo sapiens threonine synthase-like 2 (S. cerevisiae) (THNSL2),
transcript variant 1, mRNA.
ACCESSION NM_018271
VERSION NM_018271.4 GI:347658947
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1985)
AUTHORS Fox,C.S., Liu,Y., White,C.C., Feitosa,M., Smith,A.V.,
Heard-Costa,N., Lohman,K., Johnson,A.D., Foster,M.C.,
Greenawalt,D.M., Griffin,P., Ding,J., Newman,A.B., Tylavsky,F.,
Miljkovic,I., Kritchevsky,S.B., Launer,L., Garcia,M.,
Eiriksdottir,G., Carr,J.J., Gudnason,V., Harris,T.B., Cupples,L.A.
and Borecki,I.B.
CONSRTM GIANT Consortium; MAGIC Consortium; GLGC Consortium
TITLE Genome-wide association for abdominal subcutaneous and visceral
adipose reveals a novel locus for visceral fat in women
JOURNAL PLoS Genet. 8 (5), E1002695 (2012)
PUBMED 22589738
REFERENCE 2 (bases 1 to 1985)
AUTHORS Mason,C.C., Hanson,R.L., Ossowski,V., Bian,L., Baier,L.J.,
Krakoff,J. and Bogardus,C.
TITLE Bimodal distribution of RNA expression levels in human skeletal
muscle tissue
JOURNAL BMC Genomics 12, 98 (2011)
PUBMED 21299892
REMARK GeneRIF: THNSL2 was found to have bimodal expression in human
skeletal muscle tissue.
Publication Status: Online-Only
REFERENCE 3 (bases 1 to 1985)
AUTHORS Rifas,L. and Weitzmann,M.N.
TITLE A novel T cell cytokine, secreted osteoclastogenic factor of
activated T cells, induces osteoclast formation in a
RANKL-independent manner
JOURNAL Arthritis Rheum. 60 (11), 3324-3335 (2009)
PUBMED 19877052
REMARK GeneRIF: A cytokine named SOFAT (secreted osteoclastogenic factor
of activated T cells) can induce osteoblastic IL-6 production and
osteoclast formation in the absence of osteoblasts or RANKL. It is
insensitive to RANKL inhibitor osteoprotegerin.
REFERENCE 4 (bases 1 to 1985)
AUTHORS Donini,S., Percudani,R., Credali,A., Montanini,B., Sartori,A. and
Peracchi,A.
TITLE A threonine synthase homolog from a mammalian genome
JOURNAL Biochem. Biophys. Res. Commun. 350 (4), 922-928 (2006)
PUBMED 17034760
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from DA196694.1, AC092836.4,
BC035315.1 and AI313402.1.
On Sep 24, 2011 this sequence version replaced gi:149193322.
Summary: This gene encodes a threonine synthase-like protein. A
similar enzyme in mouse can catalyze the degradation of
O-phospho-homoserine to a-ketobutyrate, phosphate, and ammonia.
This protein also has phospho-lyase activity on both gamma and beta
phosphorylated substrates. In mouse an alternatively spliced form
of this protein has been shown to act as a cytokine and can induce
the production of the inflammatory cytokine IL6 in osteoblasts.
Alternate splicing results in multiple transcript variants.
[provided by RefSeq, Sep 2011].
Transcript Variant: This variant (1) encodes the longest isoform
(1).
Sequence Note: This RefSeq record was created from transcript and
genomic sequence data to make the sequence consistent with the
reference genome assembly. The genomic coordinates used for the
transcript record were based on transcript alignments.
##Evidence-Data-START##
Transcript exon combination :: AK095303.1, BC035315.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025082, ERS025084 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-133 DA196694.1 332-464
134-134 AC092836.4 106457-106457
135-169 DA196694.1 466-500
170-1797 BC035315.1 1-1628
1798-1971 BC035315.1 1630-1803
1972-1985 AI313402.1 1-14 c
FEATURES Location/Qualifiers
source 1..1985
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="2"
/map="2p11.2"
gene 1..1985
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/note="threonine synthase-like 2 (S. cerevisiae)"
/db_xref="GeneID:55258"
/db_xref="HGNC:25602"
/db_xref="MIM:611261"
exon 1..235
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/inference="alignment:Splign:1.39.8"
CDS 13..1467
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/EC_number="4.2.3.-"
/note="isoform 1 is encoded by transcript variant 1;
secreted osteoclastogenic factor of activated T cells"
/codon_start=1
/product="threonine synthase-like 2 isoform 1"
/protein_id="NP_060741.3"
/db_xref="GI:149193323"
/db_xref="CCDS:CCDS2002.2"
/db_xref="GeneID:55258"
/db_xref="HGNC:25602"
/db_xref="MIM:611261"
/translation="
MWYVSTRGVAPRVNFEGALFSGYAPDGGLFMPEELPQLDRGTLCQWSTLSYPGLVKELCALFIGSELLPKDELNDLIDRAFSRFRHREVVHLSRLRNGLNVLELWHGVTYAFKDLSLSCTTQFLQYFLEKREKHVTVVVGTSGDTGSAAIESVQGAKNMDIIVLLPKGHCTKIQELQMTTVLKQNVHVFGVEGNSDELDEPIKTVFADVAFVKKHNLMSLNSINWSRVLVQMAHHFFAYFQCTPSLDTHPLPLVEVVVPTGAAGNLAAGYIAQKIGLPIRLVVAVNRNDIIHRTVQQGDFSLSEAVKSTLASAMDIQVPYNMERVFWLLSGSDSQVTRALMEQFERTQSVNLPKELHSKLSEAVTSVSVSDEAITQTMGRCWDENQYLLCPHSAVAVNYHYQQIDRQQPSTPRCCLAPASAAKFPEAVLAAGLTPETPAEIVALEHKETRCTLMRRGDNWMLMLRDTIEDLSRQWRSHALNTSQ
"
misc_feature 13..1371
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/note="Threonine synthase [Amino acid transport and
metabolism]; Region: ThrC; COG0498"
/db_xref="CDD:30844"
misc_feature 16..1404
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/note="Threonine synthase catalyzes the final step of
threonine biosynthesis. The conversion of
O-phosphohomoserine into threonine and inorganic phosphate
is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD
includes members from higher plants, cyanobacteria;
Region: Thr-synth_2; cd01560"
/db_xref="CDD:107203"
misc_feature order(349..351,793..798,1264..1266)
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/note="pyridoxal 5'-phosphate binding site [chemical
binding]; other site"
/db_xref="CDD:107203"
misc_feature 349..351
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/note="catalytic residue [active]"
/db_xref="CDD:107203"
variation 36
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="c"
/replace="t"
/db_xref="dbSNP:367785526"
variation 44
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="c"
/replace="t"
/db_xref="dbSNP:374311669"
variation 47
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="a"
/replace="g"
/db_xref="dbSNP:139953850"
variation 77
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="a"
/replace="g"
/db_xref="dbSNP:369820777"
variation 80
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="a"
/replace="g"
/db_xref="dbSNP:151033743"
variation 89
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="a"
/replace="g"
/db_xref="dbSNP:373551702"
variation 90
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="c"
/replace="t"
/db_xref="dbSNP:114858196"
variation 134
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="a"
/replace="g"
/db_xref="dbSNP:4129190"
variation 141
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="a"
/replace="g"
/db_xref="dbSNP:370944153"
variation 143
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="a"
/replace="g"
/db_xref="dbSNP:146704484"
variation 152
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="g"
/replace="t"
/db_xref="dbSNP:143468353"
variation 154
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="a"
/replace="g"
/db_xref="dbSNP:142011143"
variation 175
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="g"
/replace="t"
/db_xref="dbSNP:147509382"
variation 226
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="c"
/replace="g"
/db_xref="dbSNP:199500112"
exon 236..430
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/inference="alignment:Splign:1.39.8"
variation 243
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="c"
/replace="t"
/db_xref="dbSNP:371211298"
variation 244
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="c"
/replace="t"
/db_xref="dbSNP:34841493"
variation 248
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="a"
/replace="g"
/db_xref="dbSNP:376146285"
variation 251
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="c"
/replace="g"
/db_xref="dbSNP:142704703"
variation 266
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="a"
/replace="g"
/db_xref="dbSNP:376220295"
variation 292
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="a"
/replace="g"
/db_xref="dbSNP:143431033"
variation 315
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="g"
/replace="t"
/db_xref="dbSNP:199609866"
variation 331
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="a"
/replace="g"
/db_xref="dbSNP:145369179"
variation 334
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="c"
/replace="t"
/db_xref="dbSNP:35541720"
variation 351
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="g"
/replace="t"
/db_xref="dbSNP:149024211"
variation 373
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="a"
/replace="g"
/db_xref="dbSNP:143018511"
variation 376
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="c"
/replace="t"
/db_xref="dbSNP:143306537"
variation 401
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="a"
/replace="g"
/db_xref="dbSNP:111555319"
variation 407
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="a"
/replace="c"
/db_xref="dbSNP:137996561"
variation 414
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="c"
/replace="t"
/db_xref="dbSNP:149479181"
variation 415
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="a"
/replace="g"
/db_xref="dbSNP:192084638"
exon 431..583
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/inference="alignment:Splign:1.39.8"
variation 441
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="g"
/replace="t"
/db_xref="dbSNP:75522866"
variation 481
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="a"
/replace="g"
/db_xref="dbSNP:375276075"
variation 494
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="g"
/replace="t"
/db_xref="dbSNP:139757275"
variation 535
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="g"
/replace="t"
/db_xref="dbSNP:144678899"
variation 544
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="a"
/replace="t"
/db_xref="dbSNP:372908030"
variation 550
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="a"
/replace="g"
/db_xref="dbSNP:374885568"
variation 551
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="c"
/replace="t"
/db_xref="dbSNP:369239668"
variation 568
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="a"
/replace="g"
/db_xref="dbSNP:371602854"
exon 584..814
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/inference="alignment:Splign:1.39.8"
variation 606
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="c"
/replace="t"
/db_xref="dbSNP:146726960"
variation 623
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="g"
/replace="t"
/db_xref="dbSNP:34136143"
variation 627
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="a"
/replace="g"
/db_xref="dbSNP:150966723"
variation 633
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="c"
/replace="t"
/db_xref="dbSNP:116861191"
variation 634
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="a"
/replace="g"
/db_xref="dbSNP:369508046"
variation 740
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="a"
/replace="g"
/db_xref="dbSNP:34250376"
variation 753
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="c"
/replace="t"
/db_xref="dbSNP:149200089"
variation 799
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="c"
/replace="g"
/db_xref="dbSNP:370334316"
variation 802
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="a"
/replace="g"
/db_xref="dbSNP:141464891"
exon 815..963
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/inference="alignment:Splign:1.39.8"
variation 826
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="g"
/replace="t"
/db_xref="dbSNP:371763302"
variation 831
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="a"
/replace="g"
/db_xref="dbSNP:73949231"
variation 851
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="a"
/replace="g"
/db_xref="dbSNP:375483620"
variation 855
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="c"
/replace="t"
/db_xref="dbSNP:35051888"
variation 858
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="c"
/replace="g"
/db_xref="dbSNP:148640386"
variation 859
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="a"
/replace="g"
/db_xref="dbSNP:147776956"
variation 871
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="c"
/replace="t"
/db_xref="dbSNP:368558816"
variation 882
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="a"
/replace="c"
/db_xref="dbSNP:145009340"
variation 891
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="a"
/replace="g"
/db_xref="dbSNP:200402354"
variation 908
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="a"
/replace="c"
/db_xref="dbSNP:375964297"
variation 933
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="a"
/replace="g"
/db_xref="dbSNP:141094872"
exon 964..1089
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/inference="alignment:Splign:1.39.8"
variation 970
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="c"
/replace="t"
/db_xref="dbSNP:138871561"
variation 982
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="a"
/replace="g"
/db_xref="dbSNP:17855905"
variation 983
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="g"
/replace="t"
/db_xref="dbSNP:199612488"
variation 985
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="a"
/replace="g"
/db_xref="dbSNP:376687469"
variation 993
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="a"
/replace="c"
/db_xref="dbSNP:36125522"
variation 1024
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="a"
/replace="g"
/db_xref="dbSNP:369834788"
variation 1076
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="a"
/replace="g"
/db_xref="dbSNP:374321239"
exon 1090..1241
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/inference="alignment:Splign:1.39.8"
variation 1111
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="a"
/replace="g"
/db_xref="dbSNP:368972090"
variation 1151
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="a"
/replace="g"
/db_xref="dbSNP:377730165"
variation 1170
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="c"
/replace="g"
/db_xref="dbSNP:371434708"
variation 1186
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="c"
/replace="g"
/db_xref="dbSNP:200804670"
variation 1200
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="c"
/replace="t"
/db_xref="dbSNP:374796449"
variation 1201
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="a"
/replace="g"
/db_xref="dbSNP:144146961"
exon 1242..1981
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/inference="alignment:Splign:1.39.8"
variation 1264
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="c"
/replace="t"
/db_xref="dbSNP:76963547"
variation 1281
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="c"
/replace="g"
/db_xref="dbSNP:377665314"
variation 1327
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="a"
/replace="g"
/db_xref="dbSNP:200685654"
variation 1328
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="c"
/replace="t"
/db_xref="dbSNP:375608550"
variation 1341
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="c"
/replace="t"
/db_xref="dbSNP:368148454"
variation 1348
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="c"
/replace="t"
/db_xref="dbSNP:200077966"
variation 1350
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="c"
/replace="t"
/db_xref="dbSNP:370502681"
variation 1360
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="c"
/replace="t"
/db_xref="dbSNP:143087335"
variation 1376
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="a"
/replace="g"
/db_xref="dbSNP:151161854"
variation 1405
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="c"
/replace="t"
/db_xref="dbSNP:367584313"
variation 1406
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="a"
/replace="g"
/db_xref="dbSNP:372281823"
variation 1457
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="c"
/replace="t"
/db_xref="dbSNP:141207786"
variation 1467
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="g"
/replace="t"
/db_xref="dbSNP:3210976"
variation 1526
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="c"
/replace="t"
/db_xref="dbSNP:78594831"
variation 1533
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="c"
/replace="t"
/db_xref="dbSNP:146940055"
STS 1662..1966
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/standard_name="D2S2610"
/db_xref="UniSTS:37791"
variation 1748
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="a"
/replace="g"
/db_xref="dbSNP:3183983"
variation 1793..1794
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace=""
/replace="c"
/db_xref="dbSNP:3215271"
STS 1818..1952
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/standard_name="RH47580"
/db_xref="UniSTS:63546"
variation 1824
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="c"
/replace="t"
/db_xref="dbSNP:115884283"
variation 1852
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="c"
/replace="t"
/db_xref="dbSNP:1127735"
variation 1896
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="c"
/replace="t"
/db_xref="dbSNP:1127736"
variation 1903
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
/replace="a"
/replace="c"
/db_xref="dbSNP:1127738"
polyA_signal 1949..1954
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
polyA_site 1981
/gene="THNSL2"
/gene_synonym="SOFAT; THS2; TSH2"
ORIGIN
gcctccaggatcatgtggtatgtcagcaccaggggcgtagccccacgggtcaactttgagggggccctcttctctggctatgcacctgacgggggcctctttatgcctgaagagctcccacagttggacagagggaccctgtgccagtggagcacactctcctatcctggcctggtgaaggagctgtgtgccctcttcattggctctgagctccttccaaaagatgaattaaatgatctgatcgaccgagccttcagcagattccgtcacagagaagtggtccatctgtccaggttgaggaatgggctgaacgtgttggagctgtggcatggcgtcacatatgcatttaaggacctgtccctgtcctgcacaacacagttcctgcagtacttcctggagaagagggagaagcacgtcactgtggttgtaggaacatctggggacacaggaagtgctgccattgagagtgttcaaggggcaaagaacatggacattatcgttctgctgcccaaaggtcactgcacaaagattcaggagctccagatgacaacggtgctgaagcagaacgtacatgtgtttggagtggagggaaacagcgatgagctcgatgagccgatcaagactgtgtttgccgatgtggcttttgtcaagaagcacaatctgatgagcctgaattcgatcaactggtcccgggtcctggtgcagatggcccatcacttctttgcttacttccagtgtacgccatccttggacacacatcccctacccctggtggaggtggttgtgccaacaggggctgccggtaaccttgcagctgggtacattgctcaaaagataggcctgcccatccgtctggtcgtggcagtgaaccgcaatgacatcatccacaggactgtccagcagggagacttctctctctctgaggctgttaaatcaaccttggcatcagctatggacattcaggtgccctacaacatggagagggtgttctggctgctctctggctctgacagccaggtgacaagagccctcatggagcagtttgaaaggacccaaagtgtgaatctgcccaaggaactgcacagcaagctttcagaggcagtgacatccgtgtcagtgtcggatgaagccatcacccagaccatgggccgctgctgggatgagaaccagtacttgctgtgcccccactcagcggtggccgtgaactaccattaccagcagatagacaggcagcagcccagcactccccggtgctgcctcgcccctgcctctgcagccaagttcccggaagctgtcctggctgctggcctgacccctgagactcccgcggagatcgtagccctggagcacaaggagacacgctgcaccctgatgcggagaggtgacaactggatgctgatgcttcgggacaccattgaggaccttagccgacagtggaggagtcatgccctcaacacctcccagtagcctggctggaggtggctttctttaggcttcagatcccaggaagatgcaccttctgagctgccttgtgcaccctccccattaagcgtaggttaggaggtttccgggaggctgctcagctggatctggagccagctggctttgctccgttccctggctagtctgtgcctggtcaccagggaggctgagtgaggggctgtgaacagttgccggaagcaccccctccctccccggcccgtgcagcagtgtctgagctgtagtgaaagtttcagggcctgcaaaagaagaggcttgggcacaggactgaccatggctccaggggtttaggaccccagacctgtgaaggtgggagcagctcaccaccttcacgcaggctttgtatgttctctgagccttagttgattttggcccccaaaccaaatccaaaggttctggcccaccttgtcagaggcttccaccctgctcacatgttgggaatccctggaataaaatgcttgttcagtgtgatggagcggcaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:55258 -> Molecular function: GO:0003674 [molecular_function] evidence: ND
GeneID:55258 -> Molecular function: GO:0005125 [cytokine activity] evidence: IEA
GeneID:55258 -> Molecular function: GO:0016829 [lyase activity] evidence: IEA
GeneID:55258 -> Molecular function: GO:0030170 [pyridoxal phosphate binding] evidence: ISS
GeneID:55258 -> Molecular function: GO:0070905 [serine binding] evidence: ISS
GeneID:55258 -> Biological process: GO:0008150 [biological_process] evidence: ND
GeneID:55258 -> Biological process: GO:0009071 [serine family amino acid catabolic process] evidence: ISS
GeneID:55258 -> Biological process: GO:0016311 [dephosphorylation] evidence: ISS
GeneID:55258 -> Biological process: GO:0046360 [2-oxobutyrate biosynthetic process] evidence: ISS
GeneID:55258 -> Cellular component: GO:0005575 [cellular_component] evidence: ND
GeneID:55258 -> Cellular component: GO:0005615 [extracellular space] evidence: IEA
ANNOTATIONS from NCBI Entrez Gene (20130726):
NP_060741 -> EC 4.2.3.-
by
@meso_cacase at
DBCLS
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