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2024-03-29 02:03:36, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_014943               4373 bp    mRNA    linear   PRI 17-APR-2013
DEFINITION  Homo sapiens zinc fingers and homeoboxes 2 (ZHX2), mRNA.
ACCESSION   NM_014943
VERSION     NM_014943.3  GI:63079684
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4373)
  AUTHORS   Fuller,D.M., Zhu,M., Koonpaew,S., Nelson,M.I. and Zhang,W.
  TITLE     The importance of the Erk pathway in the development of linker for
            activation of T cells-mediated autoimmunity
  JOURNAL   J. Immunol. 189 (8), 4005-4013 (2012)
   PUBMED   22984075
  REMARK    GeneRIF: Expression of a constitutively active Raf transgene
            enhances lymphoproliferation, indicating a role for the Ras-MAPK
            pathway in linker for activation of T cells (LAT)-mediated
            autoimmune hyperproliferation.
REFERENCE   2  (bases 1 to 4373)
  AUTHORS   Ovsyannikova,I.G., Kennedy,R.B., O'Byrne,M., Jacobson,R.M.,
            Pankratz,V.S. and Poland,G.A.
  TITLE     Genome-wide association study of antibody response to smallpox
            vaccine
  JOURNAL   Vaccine 30 (28), 4182-4189 (2012)
   PUBMED   22542470
REFERENCE   3  (bases 1 to 4373)
  AUTHORS   Overlack,N., Goldmann,T., Wolfrum,U. and Nagel-Wolfrum,K.
  TITLE     Gene repair of an Usher syndrome causing mutation by zinc-finger
            nuclease mediated homologous recombination
  JOURNAL   Invest. Ophthalmol. Vis. Sci. 53 (7), 4140-4146 (2012)
   PUBMED   22661463
  REMARK    GeneRIF: simultaneous application of ZFN and rescue DNA induced
            gene repair of the disease-causing mutation on the genomic level,
            resulting in recovery of protein expression.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4373)
  AUTHORS   Nagel,S., Schneider,B., Meyer,C., Kaufmann,M., Drexler,H.G. and
            Macleod,R.A.
  TITLE     Transcriptional deregulation of homeobox gene ZHX2 in Hodgkin
            lymphoma
  JOURNAL   Leuk. Res. 36 (5), 646-655 (2012)
   PUBMED   22078940
  REMARK    GeneRIF: results demonstrate multiple mechanisms decreasing
            expression of tumor suppressor gene ZHX2 in Hodgkin lymphoma cell
            lines
REFERENCE   5  (bases 1 to 4373)
  AUTHORS   Nagel,S., Schneider,B., Rosenwald,A., Meyer,C., Kaufmann,M.,
            Drexler,H.G. and MacLeod,R.A.
  TITLE     t(4;8)(q27;q24) in Hodgkin lymphoma cells targets phosphodiesterase
            PDE5A and homeobox gene ZHX2
  JOURNAL   Genes Chromosomes Cancer 50 (12), 996-1009 (2011)
   PUBMED   21987443
  REMARK    GeneRIF: Expression profiling of L-1236 cells following
            siRNA-mediated knockdown of ZHX2 showed inhibition of genes
            regulating differentiation and apoptosis, suggesting tumor
            suppressor activity of ZHX2.
REFERENCE   6  (bases 1 to 4373)
  AUTHORS   Liu,G., Clement,L.C., Kanwar,Y.S., Avila-Casado,C. and Chugh,S.S.
  TITLE     ZHX proteins regulate podocyte gene expression during the
            development of nephrotic syndrome
  JOURNAL   J. Biol. Chem. 281 (51), 39681-39692 (2006)
   PUBMED   17056598
  REMARK    GeneRIF: ZHX proteins 1, 2 and 3 are major transcriptional
            mediators of podocyte disease
            Erratum:[J Biol Chem. 2007 Apr 27;282(17):13140]
REFERENCE   7  (bases 1 to 4373)
  AUTHORS   de Andrade,T.G., Peterson,K.R., Cunha,A.F., Moreira,L.S.,
            Fattori,A., Saad,S.T. and Costa,F.F.
  TITLE     Identification of novel candidate genes for globin regulation in
            erythroid cells containing large deletions of the human beta-globin
            gene cluster
  JOURNAL   Blood Cells Mol. Dis. 37 (2), 82-90 (2006)
   PUBMED   16952470
  REMARK    GeneRIF: ZHX2, a transcriptional repressor, may participate in
            globin gene regulation.
REFERENCE   8  (bases 1 to 4373)
  AUTHORS   Lim,J., Hao,T., Shaw,C., Patel,A.J., Szabo,G., Rual,J.F.,
            Fisk,C.J., Li,N., Smolyar,A., Hill,D.E., Barabasi,A.L., Vidal,M.
            and Zoghbi,H.Y.
  TITLE     A protein-protein interaction network for human inherited ataxias
            and disorders of Purkinje cell degeneration
  JOURNAL   Cell 125 (4), 801-814 (2006)
   PUBMED   16713569
REFERENCE   9  (bases 1 to 4373)
  AUTHORS   Kawata,H., Yamada,K., Shou,Z., Mizutani,T. and Miyamoto,K.
  TITLE     The mouse zinc-fingers and homeoboxes (ZHX) family; ZHX2 forms a
            heterodimer with ZHX3
  JOURNAL   Gene 323, 133-140 (2003)
   PUBMED   14659886
REFERENCE   10 (bases 1 to 4373)
  AUTHORS   Kawata,H., Yamada,K., Shou,Z., Mizutani,T., Yazawa,T., Yoshino,M.,
            Sekiguchi,T., Kajitani,T. and Miyamoto,K.
  TITLE     Zinc-fingers and homeoboxes (ZHX) 2, a novel member of the ZHX
            family, functions as a transcriptional repressor
  JOURNAL   Biochem. J. 373 (PT 3), 747-757 (2003)
   PUBMED   12741956
  REMARK    GeneRIF: identification as a transcriptional repressor
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BM148156.1, BC042145.1,
            AC104316.3 and AI334237.1.
            On May 6, 2005 this sequence version replaced gi:31543977.
            
            Summary: The members of the zinc fingers and homeoboxes gene family
            are nuclear homodimeric transcriptional repressors that interact
            with the A subunit of nuclear factor-Y (NF-YA) and contain two
            C2H2-type zinc fingers and five homeobox DNA-binding domains. This
            gene encodes member 2 of this gene family. In addition to forming
            homodimers, this protein heterodimerizes with member 1 of the zinc
            fingers and homeoboxes family. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC042145.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           ERS025081, ERS025082 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-51                BM148156.1         5-55
            52-189              BM148156.1         57-194
            190-3311            BC042145.1         102-3223
            3312-3312           AC104316.3         95711-95711
            3313-3576           BC042145.1         3225-3488
            3577-3577           AC104316.3         95976-95976
            3578-4225           BC042145.1         3490-4137
            4226-4253           AC104316.3         96625-96652
            4254-4354           BC042145.1         4166-4266
            4355-4373           AI334237.1         1-19                c
FEATURES             Location/Qualifiers
     source          1..4373
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q24.13"
     gene            1..4373
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /note="zinc fingers and homeoboxes 2"
                     /db_xref="GeneID:22882"
                     /db_xref="HGNC:18513"
                     /db_xref="HPRD:16458"
                     /db_xref="MIM:609185"
     exon            1..285
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /inference="alignment:Splign:1.39.8"
     variation       40
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace=""
                     /replace="c"
                     /db_xref="dbSNP:200249449"
     variation       42
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:57076121"
     variation       54
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace=""
                     /replace="t"
                     /db_xref="dbSNP:370222853"
     variation       84
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:13261590"
     exon            286..348
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /inference="alignment:Splign:1.39.8"
     variation       295
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:16897571"
     exon            349..3085
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /inference="alignment:Splign:1.39.8"
     variation       383
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:192404933"
     variation       400
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:62522666"
     variation       405
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:144768655"
     misc_feature    472..474
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /note="upstream in-frame stop codon"
     variation       515
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:116771558"
     variation       545
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:372182520"
     CDS             568..3081
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /note="zinc-fingers and homeoboxes 2; transcription factor
                     ZHX2; AFP regulator 1; regulator of AFP; alpha-fetoprotein
                     regulator 1; zinc finger and homeodomain protein 2"
                     /codon_start=1
                     /product="zinc fingers and homeoboxes protein 2"
                     /protein_id="NP_055758.1"
                     /db_xref="GI:7662342"
                     /db_xref="CCDS:CCDS6336.1"
                     /db_xref="GeneID:22882"
                     /db_xref="HGNC:18513"
                     /db_xref="HPRD:16458"
                     /db_xref="MIM:609185"
                     /translation="
MASKRKSTTPCMVRTSQVVEQDVPEEVDRAKEKGIGTPQPDVAKDSWAAELENSSKENEVIEVKSMGESQSKKLQGGYECKYCPYSTQNLNEFTEHVDMQHPNVILNPLYVCAECNFTTKKYDSLSDHNSKFHPGEANFKLKLIKRNNQTVLEQSIETTNHVVSITTSGPGTGDSDSGISVSKTPIMKPGKPKADAKKVPKKPEEITPENHVEGTARLVTDTAEILSRLGGVELLQDTLGHVMPSVQLPPNINLVPKVPVPLNTTKYNSALDTNATMINSFNKFPYPTQAELSWLTAASKHPEEHIRIWFATQRLKHGISWSPEEVEEARKKMFNGTIQSVPPTITVLPAQLAPTKVTQPILQTALPCQILGQTSLVLTQVTSGSTTVSCSPITLAVAGVTNHGQKRPLVTPQAAPEPKRPHIAQVPEPPPKVANPPLTPASDRKKTKEQIAHLKASFLQSQFPDDAEVYRLIEVTGLARSEIKKWFSDHRYRCQRGIVHITSESLAKDQLAIAASRHGRTYHAYPDFAPQKFKEKTQGQVKILEDSFLKSSFPTQAELDRLRVETKLSRREIDSWFSERRKLRDSMEQAVLDSMGSGKKGQDVGAPNGALSRLDQLSGAQLTSSLPSPSPAIAKSQEQVHLLRSTFARTQWPTPQEYDQLAAKTGLVRTEIVRWFKENRCLLKTGTVKWMEQYQHQPMADDHGYDAVARKATKPMAESPKNGGDVVPQYYKDPKKLCEEDLEKLVTRVKVGSEPAKDCLPAKPSEATSDRSEGSSRDGQGSDENEESSVVDYVEVTVGEEDAISDRSDSWSQAAAEGVSELAESDSDCVPAEAGQA
"
     misc_feature    1150..1641
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Y6X8.1);
                     Region: Required for homodimerization"
     misc_feature    1354..2058
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Y6X8.1);
                     Region: Required for interaction with NFYA"
     misc_feature    1354..1905
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Y6X8.1);
                     Region: Required for repressor activity"
     misc_feature    1381..1530
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /note="Homeodomain;  DNA binding domains involved in the
                     transcriptional regulation of key eukaryotic developmental
                     processes; may bind to DNA as monomers or as homo- and/or
                     heterodimers, in a sequence-specific manner; Region:
                     homeodomain; cd00086"
                     /db_xref="CDD:28970"
     misc_feature    order(1423..1425,1441..1443,1480..1482,1486..1491,
                     1498..1503,1507..1515,1519..1524)
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:28970"
     misc_feature    order(1489..1491,1498..1503,1510..1512)
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /note="specific DNA base contacts [nucleotide binding];
                     other site"
                     /db_xref="CDD:28970"
     misc_feature    1516..1905
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Y6X8.1);
                     Region: Required for nuclear localization"
     misc_feature    1897..2055
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /note="Homeodomain;  DNA binding domains involved in the
                     transcriptional regulation of key eukaryotic developmental
                     processes; may bind to DNA as monomers or as homo- and/or
                     heterodimers, in a sequence-specific manner; Region:
                     homeodomain; cd00086"
                     /db_xref="CDD:28970"
     misc_feature    order(1897..1899,1903..1905,1954..1956,1972..1974,
                     2011..2013,2017..2022,2029..2034,2038..2046,2050..2055)
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:28970"
     misc_feature    order(1900..1902,2020..2022,2029..2034,2041..2043)
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /note="specific DNA base contacts [nucleotide binding];
                     other site"
                     /db_xref="CDD:28970"
     misc_feature    2155..2313
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /note="Homeodomain;  DNA binding domains involved in the
                     transcriptional regulation of key eukaryotic developmental
                     processes; may bind to DNA as monomers or as homo- and/or
                     heterodimers, in a sequence-specific manner; Region:
                     homeodomain; cd00086"
                     /db_xref="CDD:28970"
     misc_feature    order(2155..2169,2173..2175,2224..2226,2242..2244,
                     2281..2283,2287..2292,2299..2304,2308..2313)
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:28970"
     misc_feature    order(2161..2163,2170..2172,2290..2292,2299..2304,
                     2311..2313)
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /note="specific DNA base contacts [nucleotide binding];
                     other site"
                     /db_xref="CDD:28970"
     misc_feature    2470..2619
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /note="Homeodomain;  DNA binding domains involved in the
                     transcriptional regulation of key eukaryotic developmental
                     processes; may bind to DNA as monomers or as homo- and/or
                     heterodimers, in a sequence-specific manner; Region:
                     homeodomain; cd00086"
                     /db_xref="CDD:28970"
     misc_feature    order(2470..2472,2521..2523,2539..2541,2578..2580,
                     2584..2589,2596..2601,2605..2613,2617..2619)
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:28970"
     misc_feature    order(2587..2589,2596..2601,2608..2610)
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /note="specific DNA base contacts [nucleotide binding];
                     other site"
                     /db_xref="CDD:28970"
     variation       593
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:147897583"
     variation       597
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:146817834"
     variation       608
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:140571061"
     variation       609
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:144209659"
     variation       623
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201285505"
     variation       624
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:371607208"
     variation       640
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:146538096"
     variation       673
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:140461950"
     variation       690
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:140432187"
     variation       691
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:375028357"
     variation       714
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:368995594"
     variation       718
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201553642"
     variation       741
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:35460327"
     variation       742
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:373708916"
     variation       754
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:61762976"
     variation       813
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:4871331"
     variation       828
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:61752912"
     variation       840
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:145165454"
     variation       849
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:377560517"
     variation       852
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:138740642"
     variation       855
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:4871332"
     variation       862
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:146938434"
     variation       897
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:73335724"
     variation       898
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:142031452"
     variation       903
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:150692889"
     variation       933
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:139940405"
     variation       942
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:149407080"
     variation       945
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200640976"
     variation       968
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201126119"
     variation       971
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:376815007"
     variation       1003
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:146351736"
     variation       1004
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199651758"
     variation       1015
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:199765828"
     variation       1020
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:200717446"
     variation       1029
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:139634856"
     variation       1072
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:75046616"
     variation       1075
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:372944259"
     variation       1088
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:145158124"
     variation       1173
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:377327558"
     variation       1192
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:202189564"
     variation       1197
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:111854627"
     variation       1201
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:35760254"
     variation       1212
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:184731017"
     variation       1221
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:35865254"
     variation       1235
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:371184369"
     variation       1248
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:3204141"
     variation       1255
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:373301078"
     variation       1257
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:142739771"
     variation       1258
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:376446251"
     variation       1303
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:151010794"
     variation       1309
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:373784562"
     variation       1316
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:376295518"
     variation       1341
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:370672302"
     variation       1395
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:140865098"
     variation       1428
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:374124857"
     variation       1435
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace=""
                     /replace="g"
                     /db_xref="dbSNP:5894650"
     variation       1482
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:368430233"
     variation       1487
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:372425134"
     variation       1526
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:34498734"
     variation       1542
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:376005552"
     variation       1572
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:36092924"
     variation       1584
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:16897795"
     variation       1587
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:200180193"
     variation       1591
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:116577713"
     variation       1596
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:372880887"
     variation       1614
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:146955427"
     variation       1615
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:375789703"
     variation       1630
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:113444944"
     variation       1636
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:9649951"
     variation       1638
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200087554"
     variation       1658
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:369120446"
     variation       1659
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:372060090"
     variation       1663
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:375286966"
     variation       1668
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:143007490"
     variation       1671
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:202068049"
     variation       1680
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201657146"
     variation       1692
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:373199431"
     variation       1717
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201080427"
     variation       1727
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:370753355"
     variation       1729
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:142123946"
     variation       1755
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:375244930"
     variation       1770
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:3808600"
     variation       1789
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:139674940"
     variation       1789
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace=""
                     /replace="c"
                     /db_xref="dbSNP:35054451"
     variation       1796
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:142894115"
     variation       1834
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:146090274"
     variation       1836
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:139727089"
     variation       1837
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:145385431"
     variation       1854
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:373531815"
     variation       1868
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:376976315"
     variation       1872
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:370328879"
     variation       1877
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200614161"
     variation       1878
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:374578204"
     variation       1962
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:149774253"
     variation       1968
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:145695205"
     variation       1986
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:148698137"
     variation       1987
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:374724083"
     variation       1991
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201501365"
     variation       2010
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:111726812"
     variation       2033
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:75116990"
     variation       2061
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:147834952"
     variation       2062
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:202088448"
     variation       2077
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200660453"
     variation       2078
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:199705429"
     variation       2093
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:141332175"
     variation       2101
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:145188558"
     variation       2105
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:371741361"
     variation       2109
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201353584"
     variation       2117
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:150960774"
     variation       2121
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:116461280"
     variation       2122
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:137944558"
     variation       2136
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:369677113"
     variation       2139
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199852087"
     variation       2182
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:113667086"
     variation       2232
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:145887684"
     variation       2249
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:138450443"
     variation       2279
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:202202495"
     variation       2286
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:142958129"
     variation       2301
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:34092125"
     variation       2308
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:148330792"
     variation       2309
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:377449628"
     variation       2361
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:141456875"
     variation       2390
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:150834154"
     variation       2405
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:139249386"
     variation       2409
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:144568529"
     variation       2410
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:181151109"
     variation       2418
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:201212470"
     variation       2422
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:147432495"
     variation       2430
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:373967421"
     variation       2438
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200270370"
     variation       2456
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:150510685"
     variation       2457
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:202138105"
     variation       2461
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:370990863"
     variation       2485
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:201376137"
     variation       2504
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201034843"
     variation       2505
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:368727772"
     variation       2513
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:35319449"
     variation       2527
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:139727759"
     variation       2541
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:199783339"
     variation       2542
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200753877"
     variation       2573
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200646419"
     variation       2584
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199503659"
     variation       2586
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:373654140"
     variation       2611
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:73335725"
     variation       2617
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:367798040"
     variation       2621
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:139442320"
     variation       2629
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:144984915"
     variation       2653
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:371624131"
     variation       2669
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:201478824"
     variation       2676
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:375035673"
     variation       2682
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:149065954"
     variation       2688
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:186468091"
     variation       2698
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:201952083"
     variation       2710
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:74549937"
     variation       2718
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:151153297"
     variation       2754
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:190859288"
     variation       2770
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:372010119"
     variation       2782
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:376664586"
     variation       2787
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:140232374"
     variation       2803
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:147430109"
     variation       2825
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:369846197"
     variation       2826
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:145190965"
     variation       2869
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:141390481"
     variation       2878
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:374001930"
     variation       2879
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:201110609"
     variation       2897
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:150252730"
     variation       2901
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:376562688"
     variation       2902
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:3802264"
     variation       2914
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:368973670"
     variation       2916
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:149388421"
     variation       2931
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:12548759"
     variation       2934
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:200959981"
     variation       2935
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:148101741"
     variation       2946
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:373507471"
     variation       2947
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:368779118"
     variation       2958
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:113010849"
     variation       2976
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:3802265"
     variation       2984
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:139793225"
     variation       3022
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:145283871"
     variation       3037
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:150570834"
     variation       3054
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:371036864"
     variation       3072
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:112921289"
     exon            3086..4359
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /inference="alignment:Splign:1.39.8"
     variation       3086
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:116211945"
     variation       3107
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:147584974"
     variation       3178
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:368914545"
     variation       3179
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:73335765"
     variation       3215
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:142028187"
     variation       3227
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:78762851"
     variation       3238
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:370726916"
     variation       3239
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:143039332"
     variation       3305
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:151130744"
     variation       3312
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:3802266"
     variation       3375
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:140399644"
     variation       3400
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:150374486"
     variation       3461
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:183384095"
     variation       3475
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:185732373"
     STS             3529..3686
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /standard_name="RH47173"
                     /db_xref="UniSTS:18891"
     variation       3540
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:1129149"
     variation       3556
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:71514792"
     variation       3569
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:142539801"
     variation       3570
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:11989604"
     variation       3577
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:11544921"
     variation       3625
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:182792068"
     variation       3727
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:74563551"
     variation       3798
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:188304934"
     variation       3818
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:114291274"
     variation       3881
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11985908"
     variation       3906
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:34002508"
     variation       4076
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:78437580"
     variation       4126
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:117127698"
     STS             4193..4326
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /standard_name="WI-14759"
                     /db_xref="UniSTS:70649"
     STS             4195..4317
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /standard_name="RH41900"
                     /db_xref="UniSTS:47720"
     variation       4197
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:192789466"
     STS             4199..4326
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /standard_name="G59722"
                     /db_xref="UniSTS:137020"
     variation       4226
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:7758"
     variation       4253
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:2833"
     variation       4255
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:182290370"
     variation       4292
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:370311035"
     variation       4323
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:375421915"
     polyA_signal    4326..4331
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
     polyA_site      4359
                     /gene="ZHX2"
                     /gene_synonym="AFR1; RAF"
ORIGIN      
ttttggcgtagattccccactgatcgaggcattttttttccctttttttttcctttttttttttcttttaaaaattttggccatcgttctccgtacgggggctttttctgtctgtctgtctggctggcaggctggctttccccctctttcccacggagcccgagccgggcgcccggtggggagtggggagtgggtggggggagccagcagagttccattttggaacgcccgtgccgcgtctccgcgttcccagcccgggtccccgcgttcacagccccagcgcaggtctggatgtaccgactgcttttggaataaaaagattcccaggatgtgagcaacacgggaccgatatgatgcttcctggtgtgtttagtggttggtgccattccaattttctgtgctgaaatcattctgaaaactcaaacagtagacttcagcacacaaggaaagccaaagccatttgagggggaataaagccaaaagcctttcaccttattcgttccaagaatctcaccgccccctccttatccccctccaaaaataagccattgcacacagacaggcagcatggctagcaaacgaaaatctacaactccatgcatggttcggacatcacaagtagtagaacaagatgtgcccgaggaagtagacagggccaaagagaaaggaatcggcacaccacagcctgacgtggccaaggacagttgggcagcagaacttgaaaactcttccaaagaaaacgaagtgatagaggtgaaatctatgggggaaagccagtccaaaaaactccaaggtggttatgagtgcaaatactgcccctactccacgcaaaacctgaacgagttcacggagcatgtcgacatgcagcatcccaacgtgattctcaaccccctctacgtgtgtgcagaatgtaacttcacaaccaaaaagtacgactccctatccgaccacaactccaagttccatcccggggaggccaacttcaagctgaagttaattaaacgcaataatcaaactgtcttggaacagtccatcgaaaccaccaaccatgtcgtgtccatcaccaccagtggccctggaactggtgacagtgattctgggatctcggtgagtaaaacccccatcatgaagcctggaaaaccaaaagcggatgccaagaaggtgcccaagaagcccgaggagatcacccccgagaaccacgtggaagggaccgcccgcctggtgacagacacagctgagatcctctcgagactcggcggggtggagctcctccaagacacattaggacacgtcatgccttctgtacagctgccaccaaatatcaaccttgtgcccaaggtccctgtcccactaaatactaccaaatacaactctgccctggatacaaatgccacgatgatcaactctttcaacaagtttccttacccgacccaggctgagttgtcctggctgacagctgcctccaaacacccagaggagcacatcagaatctggtttgccacccagcgcttaaagcatggcatcagctggtccccagaagaggtggaggaggcccggaagaagatgttcaacggcaccatccagtcagtacccccgaccatcactgtgctgcccgcccagttggcccccacaaaggtgacgcagcccatcctccagacggctctaccgtgccagatcctcggccagactagcctggtgctgactcaggtgaccagcgggtcaacaaccgtctcttgctcccccatcacacttgccgtggcaggagtcaccaaccatggccagaagagacccttggtgactccccaagctgcccccgaacccaagcgtccacacatcgctcaggtgccagagcccccacccaaggtggccaaccccccgctcacaccagccagtgaccgcaagaagacaaaggagcagatagcacatctcaaggccagctttctccagagccagttccctgacgatgccgaggtttaccggctcatcgaggtgactggccttgccaggagcgagatcaagaagtggttcagtgaccaccgatatcggtgtcaaaggggcatcgtccacatcaccagcgaatcccttgccaaagaccagttggccatcgcggcctcccgacacggtcgcacgtatcatgcgtacccagactttgccccccagaagttcaaagagaaaacacagggtcaggttaaaatcttggaagacagctttttgaaaagttcttttcctacccaagcagaactggatcggctaagggtggagaccaagctgagcaggagagagatcgactcctggttctcggagaggcggaagcttcgagacagcatggaacaagctgtcttggattccatggggtctggcaaaaaaggccaagatgtgggagcccccaatggtgctctgtctcgactcgaccagctctccggtgcccagttaacaagttctctgcccagcccttcgccagcaattgcaaaaagtcaagaacaggttcatctcctgaggagcacgtttgcaagaacccagtggcctactccccaggagtacgaccagttagcggccaagactggcctggtccgaactgagattgtgcgttggttcaaggagaacagatgcttgctgaaaacgggaaccgtgaagtggatggagcagtaccagcaccagcccatggcagatgatcacggctacgatgccgtagcaaggaaagcaacaaaacccatggccgagagcccaaagaacgggggtgatgtggttccacaatattacaaggaccccaaaaagctctgcgaagaggacttggagaagttggtgaccagggtaaaagtaggcagcgagccagcaaaagactgtttgccagcaaagccctcagaggccacctcagaccggtcagagggcagcagccgggacggccagggtagcgacgagaacgaggagtcgagcgttgtggattacgtggaggtgacggtcggggaggaggatgcgatctcagatagatcagatagctggagtcaggctgcggcagaaggtgtgtcggaactggctgaatcagactccgactgcgtccctgcagaggctggccaggcctagacagggaagtctgttagaactgctgtgctgatcaacgggacgctccgtctttgaagaaagaagagatggtctctccccagccatgggccacccttgccagtgactccaagtggaactacttagctcgcgtgtgcctggagggtgcgggaagtccagcgactctcagacgcacctcccagaggaccggtgggaattgttcatagtgccaaagtcctactactgcgttttcaatgggtccttgtacatagtttgctcctctgccctagccctcacctcttgctatactggaaccgatttgtacaatgtgggaattttgttacctttttaatcaagggcaacttccttttccagcactaccattgtaaggtttttttcaggagggagggctaaccaccttgcttttctcttttctctttttcttttttttatttttgttttattaatttggggaaaggggtgttagcattagtgccatgatatctactggattttaagtagggagactttatttttaaaggtaggttgaaatttgggagatttctcggcaggaagggctgaaatccaggcccctgtctcaacttggagagaggtgacagacggcagatcttccaaatcaaattcctttccagttcttcccctggctgcctttttgggggtccctgccttagccccacacaaggctttctgaactgccaagaggggatctggcttctcaactgctcggcctcttgggccaggctgtgcccagccagccctgggagaactgggtagcaggtggctgacttctttaagcacctttctaaataccagcagaagaggctcccgcctctgttagcatgatcagtactattgtgacattaaaacaacaacaataagatcttcctatctggagggtacagaggtgaatggctttggttttcatttctcttcttcactgccttttctcggtgtggtatttgacaagattttagctcaaagcctcaccatgaattgattttttttgtttgtgtgtgtgtttgttttgggacaattttagatacctgagtgcactttttcagttagtcctaacttttaaaagaaggaaaaccaagagacatatctggtgtacgtgttgcagtatgaactctggttgcaatccctccccgtcccacactgccccccatttgagtacaccgcacaagtcaaacgctaggaagtttgaataaaaccaatttttctaacttgttgctcatttgttgtaactcaataaagcaaagactaaacatttttataacctttaaaaaaaaaaaaaa
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:22882 -> Molecular function: GO:0003700 [sequence-specific DNA binding transcription factor activity] evidence: IDA
            GeneID:22882 -> Molecular function: GO:0003714 [transcription corepressor activity] evidence: IDA
            GeneID:22882 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
            GeneID:22882 -> Molecular function: GO:0042803 [protein homodimerization activity] evidence: IDA
            GeneID:22882 -> Molecular function: GO:0043565 [sequence-specific DNA binding] evidence: IEA
            GeneID:22882 -> Molecular function: GO:0046872 [metal ion binding] evidence: IEA
            GeneID:22882 -> Molecular function: GO:0046982 [protein heterodimerization activity] evidence: IDA
            GeneID:22882 -> Biological process: GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] evidence: IDA
            GeneID:22882 -> Biological process: GO:0006351 [transcription, DNA-dependent] evidence: IEA
            GeneID:22882 -> Biological process: GO:0006402 [mRNA catabolic process] evidence: IEA
            GeneID:22882 -> Biological process: GO:0035019 [somatic stem cell maintenance] evidence: IEA
            GeneID:22882 -> Biological process: GO:0045665 [negative regulation of neuron differentiation] evidence: IEA
            GeneID:22882 -> Biological process: GO:0045892 [negative regulation of transcription, DNA-dependent] evidence: IDA
            GeneID:22882 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
            GeneID:22882 -> Cellular component: GO:0005730 [nucleolus] evidence: IDA
            GeneID:22882 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA
            GeneID:22882 -> Cellular component: GO:0005886 [plasma membrane] evidence: IDA

by @meso_cacase at DBCLS
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