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2024-04-19 08:36:42, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_014393 4161 bp mRNA linear PRI 07-JUN-2013
DEFINITION Homo sapiens staufen double-stranded RNA binding protein 2 (STAU2),
transcript variant 5, mRNA.
ACCESSION NM_014393
VERSION NM_014393.2 GI:256418992
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4161)
AUTHORS Park,E., Gleghorn,M.L. and Maquat,L.E.
TITLE Staufen2 functions in Staufen1-mediated mRNA decay by binding to
itself and its paralog and promoting UPF1 helicase but not ATPase
activity
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 110 (2), 405-412 (2013)
PUBMED 23263869
REMARK GeneRIF: Staufen2 functions in Staufen1-mediated mRNA decay by
binding to itself and its paralog and promoting UPF1 helicase but
not ATPase activity.
REFERENCE 2 (bases 1 to 4161)
AUTHORS Lebeau,G., Miller,L.C., Tartas,M., McAdam,R., Laplante,I.,
Badeaux,F., DesGroseillers,L., Sossin,W.S. and Lacaille,J.C.
TITLE Staufen 2 regulates mGluR long-term depression and Map1b mRNA
distribution in hippocampal neurons
JOURNAL Learn. Mem. 18 (5), 314-326 (2011)
PUBMED 21508097
REMARK GeneRIF: We suggest a role for Stau2 in the generation and
regulation of Map1b mRNA containing granules that are required for
mGluR-long-term depression
Publication Status: Online-Only
REFERENCE 3 (bases 1 to 4161)
AUTHORS Furic,L., Maher-Laporte,M. and DesGroseillers,L.
TITLE A genome-wide approach identifies distinct but overlapping subsets
of cellular mRNAs associated with Staufen1- and Staufen2-containing
ribonucleoprotein complexes
JOURNAL RNA 14 (2), 324-335 (2008)
PUBMED 18094122
REMARK GeneRIF: Stau1- and Stau2-mRNPs associate with distinct but
overlapping sets of cellular mRNAs.
REFERENCE 4 (bases 1 to 4161)
AUTHORS Beausoleil,S.A., Villen,J., Gerber,S.A., Rush,J. and Gygi,S.P.
TITLE A probability-based approach for high-throughput protein
phosphorylation analysis and site localization
JOURNAL Nat. Biotechnol. 24 (10), 1285-1292 (2006)
PUBMED 16964243
REFERENCE 5 (bases 1 to 4161)
AUTHORS Duchaine,T.F., Hemraj,I., Furic,L., Deitinghoff,A., Kiebler,M.A.
and DesGroseillers,L.
TITLE Staufen2 isoforms localize to the somatodendritic domain of neurons
and interact with different organelles
JOURNAL J. Cell. Sci. 115 (PT 16), 3285-3295 (2002)
PUBMED 12140260
REMARK GeneRIF: Data show that Stau2 is localized to the neuronal soma and
dendrites, but it does not colocalize with Stau1-containing
particles.
REFERENCE 6 (bases 1 to 4161)
AUTHORS Kiebler,M.A. and DesGroseillers,L.
TITLE Molecular insights into mRNA transport and local translation in the
mammalian nervous system
JOURNAL Neuron 25 (1), 19-28 (2000)
PUBMED 10707969
REMARK Review article
REFERENCE 7 (bases 1 to 4161)
AUTHORS Buchner,G., Bassi,M.T., Andolfi,G., Ballabio,A. and Franco,B.
TITLE Identification of a novel homolog of the Drosophila staufen protein
in the chromosome 8q13-q21.1 region
JOURNAL Genomics 62 (1), 113-118 (1999)
PUBMED 10585778
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from DB501161.1, Y19062.1,
AB210014.1, AK023314.1, AK001576.1 and CA311807.1.
On Aug 22, 2009 this sequence version replaced gi:7657624.
Summary: Staufen homolog 2 is a member of the family of
double-stranded RNA (dsRNA)-binding proteins involved in the
transport and/or localization of mRNAs to different subcellular
compartments and/or organelles. These proteins are characterized by
the presence of multiple dsRNA-binding domains which are required
to bind RNAs having double-stranded secondary structures. Staufen
homolog 2 shares 48.5% and 59.9% similarity with drosophila and
human staufen, respectively. The exact function of Staufen homolog
2 is not known, but since it contains 3 copies of conserved dsRNA
binding domain, it could be involved in double-stranded RNA binding
events. Several transcript variants encoding different isoforms
have been found for this gene. [provided by RefSeq, Aug 2009].
Transcript Variant: This variant (5) differs in the 5' and 3' UTRs
and coding sequence compared to variant 1. The resulting isoform
(e) has shorter and distinct N- and C-termini compared to isoform
a. Variants 5 and 6 both encode the same isoform (e).
##Evidence-Data-START##
Transcript exon combination :: Y19062.1, AB210014.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025084, ERS025088 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-105 DB501161.1 1-105
106-801 Y19062.1 1-696
802-2897 AB210014.1 698-2793
2898-3105 AK023314.1 1801-2008
3106-4135 AK001576.1 2131-3160
4136-4161 CA311807.1 1-26 c
FEATURES Location/Qualifiers
source 1..4161
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="8"
/map="8q21.11"
gene 1..4161
/gene="STAU2"
/gene_synonym="39K2; 39K3"
/note="staufen double-stranded RNA binding protein 2"
/db_xref="GeneID:27067"
/db_xref="HGNC:11371"
/db_xref="MIM:605920"
exon 1..145
/gene="STAU2"
/gene_synonym="39K2; 39K3"
/inference="alignment:Splign:1.39.8"
exon 146..258
/gene="STAU2"
/gene_synonym="39K2; 39K3"
/inference="alignment:Splign:1.39.8"
exon 259..324
/gene="STAU2"
/gene_synonym="39K2; 39K3"
/inference="alignment:Splign:1.39.8"
misc_feature 271..273
/gene="STAU2"
/gene_synonym="39K2; 39K3"
/note="upstream in-frame stop codon"
CDS 307..1746
/gene="STAU2"
/gene_synonym="39K2; 39K3"
/note="isoform e is encoded by transcript variant 5;
double-stranded RNA-binding protein Staufen homolog 2;
staufen homolog 2; staufen, RNA binding protein, homolog
2"
/codon_start=1
/product="double-stranded RNA-binding protein Staufen
homolog 2 isoform e"
/protein_id="NP_055208.2"
/db_xref="GI:256418993"
/db_xref="CCDS:CCDS6214.1"
/db_xref="GeneID:27067"
/db_xref="HGNC:11371"
/db_xref="MIM:605920"
/translation="
MLQINQMFSVQLSLGEQTWESEGSSIKKAQQAVANKALTESTLPKPVQKPPKSNVNNNPGSITPTVELNGLAMKRGEPAIYRPLDPKPFPNYRANYNFRGMYNQRYHCPVPKIFYVQLTVGNNEFFGEGKTRQAARHNAAMKALQALQNEPIPERSPQNGESGKDVDDDKDANKSEISLVFEIALKRNMPVSFEVIKESGPPHMKSFVTRVSVGEFSAEGEGNSKKLSKKRAATTVLQELKKLPPLPVVEKPKLFFKKRPKTIVKAGPEYGQGMNPISRLAQIQQAKKEKEPDYVLLSERGMPRRREFVMQVKVGNEVATGTGPNKKIAKKNAAEAMLLQLGYKASTNLQDQLEKTGENKGWSGPKPGFPEPTNNTPKGILHLSPDVYQEMEASRHKVISGTTLGYLSPKDMNQPSSSFFSISPTSNSSATIARELLMNGTSSTAEAIGLKGSSPTPPCSPVQPSKQLEYLARIQGFQV
"
misc_feature <631..747
/gene="STAU2"
/gene_synonym="39K2; 39K3"
/note="Double-stranded RNA binding motif. Binding is not
sequence specific but is highly specific for double
stranded RNA. Found in a variety of proteins including
dsRNA dependent protein kinase PKR, RNA helicases,
Drosophila staufen protein, E. coli RNase III; Region:
DSRM; cd00048"
/db_xref="CDD:28930"
misc_feature order(694..705,712..714)
/gene="STAU2"
/gene_synonym="39K2; 39K3"
/note="dsRNA binding site [nucleotide binding]; other
site"
/db_xref="CDD:28930"
misc_feature 835..1020
/gene="STAU2"
/gene_synonym="39K2; 39K3"
/note="Double-stranded RNA binding motif. Binding is not
sequence specific but is highly specific for double
stranded RNA. Found in a variety of proteins including
dsRNA dependent protein kinase PKR, RNA helicases,
Drosophila staufen protein, E. coli RNase III; Region:
DSRM; cd00048"
/db_xref="CDD:28930"
misc_feature order(847..852,973..984,991..993)
/gene="STAU2"
/gene_synonym="39K2; 39K3"
/note="dsRNA binding site [nucleotide binding]; other
site"
/db_xref="CDD:28930"
misc_feature 1129..1329
/gene="STAU2"
/gene_synonym="39K2; 39K3"
/note="Double-stranded RNA binding motif. Binding is not
sequence specific but is highly specific for double
stranded RNA. Found in a variety of proteins including
dsRNA dependent protein kinase PKR, RNA helicases,
Drosophila staufen protein, E. coli RNase III; Region:
DSRM; cd00048"
/db_xref="CDD:28930"
misc_feature order(1129..1131,1147..1152,1276..1287,1294..1296)
/gene="STAU2"
/gene_synonym="39K2; 39K3"
/note="dsRNA binding site [nucleotide binding]; other
site"
/db_xref="CDD:28930"
exon 325..484
/gene="STAU2"
/gene_synonym="39K2; 39K3"
/inference="alignment:Splign:1.39.8"
exon 485..620
/gene="STAU2"
/gene_synonym="39K2; 39K3"
/inference="alignment:Splign:1.39.8"
exon 621..780
/gene="STAU2"
/gene_synonym="39K2; 39K3"
/inference="alignment:Splign:1.39.8"
STS 757..862
/gene="STAU2"
/gene_synonym="39K2; 39K3"
/standard_name="WI-16800"
/db_xref="UniSTS:64871"
exon 781..888
/gene="STAU2"
/gene_synonym="39K2; 39K3"
/inference="alignment:Splign:1.39.8"
exon 889..1101
/gene="STAU2"
/gene_synonym="39K2; 39K3"
/inference="alignment:Splign:1.39.8"
exon 1102..1239
/gene="STAU2"
/gene_synonym="39K2; 39K3"
/inference="alignment:Splign:1.39.8"
exon 1240..1371
/gene="STAU2"
/gene_synonym="39K2; 39K3"
/inference="alignment:Splign:1.39.8"
exon 1372..1432
/gene="STAU2"
/gene_synonym="39K2; 39K3"
/inference="alignment:Splign:1.39.8"
exon 1433..4151
/gene="STAU2"
/gene_synonym="39K2; 39K3"
/inference="alignment:Splign:1.39.8"
STS 2436..2608
/gene="STAU2"
/gene_synonym="39K2; 39K3"
/standard_name="A008X48"
/db_xref="UniSTS:40608"
STS 2854..3006
/gene="STAU2"
/gene_synonym="39K2; 39K3"
/standard_name="RH93062"
/db_xref="UniSTS:85004"
STS 3269..3358
/gene="STAU2"
/gene_synonym="39K2; 39K3"
/standard_name="SHGC-56844"
/db_xref="UniSTS:43241"
variation 3510
/gene="STAU2"
/gene_synonym="39K2; 39K3"
/replace="c"
/replace="t"
/db_xref="dbSNP:1132131"
STS 3985..4112
/gene="STAU2"
/gene_synonym="39K2; 39K3"
/standard_name="WI-14265"
/db_xref="UniSTS:23423"
variation 4071
/gene="STAU2"
/gene_synonym="39K2; 39K3"
/replace="a"
/replace="g"
/db_xref="dbSNP:1132134"
polyA_site 4151
/gene="STAU2"
/gene_synonym="39K2; 39K3"
ORIGIN
gggagcgccggggaggcgggcggaggcgggcggaggcggggggcggggagcccgaggggtggaagccggcggcggccgagcggggtcagttctctgtagtgtttgccaatgttggagccgtctgcaaagtgtccccggcaagaagaggctgcctaccacaaggactttagcttactttttaaagattgaagaaaaaaaagaagacagaaaaagaagaactcaaagatacacaaagtaatttgaaccaaggctcagaagtttttggagccgtgagggatacagcagtttggtcaatattgtcttaacatgcttcaaataaatcagatgttctcagtgcagctgagtcttggtgagcagacatgggaatccgaaggcagcagtataaagaaggctcagcaggctgttgccaataaagctttgactgaatctacgcttcccaaaccagttcagaagccacccaaaagtaatgttaacaataacccaggcagtataactccaactgtggaactgaatgggcttgctatgaaaaggggagagcctgccatctacaggccattagatccaaagccattcccaaattatagagctaattacaactttcggggcatgtacaatcagaggtatcattgcccagtgcctaagatcttttatgttcagctcactgtaggaaataatgaattttttggggaaggaaagactcgacaagctgctagacacaatgctgcaatgaaagccctccaagcactgcagaatgaacctattccagaaagatctcctcagaatggtgaatcaggaaaggatgtggatgatgacaaagatgcaaataagtctgagatcagcttagtgtttgaaattgctctgaagcgaaatatgcctgtcagttttgaggttattaaagaaagtggaccaccacatatgaaaagctttgttactcgagtgtcagtaggagagttctctgcagaaggagaaggaaatagcaaaaaactctccaagaagcgcgctgcgaccaccgtcttacaggagcttaaaaaacttccacctcttcctgtggtggaaaagccaaaactattttttaaaaaacgccctaaaacaatagtaaaggccggaccagaatatggccaagggatgaaccctattagccgcctggcgcaaattcaacaggccaaaaaggaaaaggagccggattatgttttgctttcagaaagaggaatgcctcgacgtcgagaatttgtgatgcaggtgaaggtaggcaatgaagttgctacaggaacaggacctaataaaaagatagccaaaaaaaatgctgcagaagcaatgctgttacaacttggttataaagcatccactaatcttcaggatcaacttgagaagacaggggaaaacaaaggatggagtggtccaaagcctgggtttcctgaaccaacaaataatactccaaaaggaattcttcatttgtctcctgatgtttatcaagagatggaagccagccgccacaaagtaatctctggcactactctaggctatttgtcacccaaagatatgaaccaaccttcaagctctttcttcagtatatctcccacatcgaatagttcagctacaattgccagggaactccttatgaatggaacatcttctacagctgaagccataggtttaaaaggaagttctcctactcccccttgttctccagtacaaccttcaaaacaactggaatatttagcaaggattcaaggctttcaggtatgaattaaaagcaaaaacaaaaaacaaaacaattcattagcctcagattcttcatctgtatacatcacaaggctcattcttgcctgctagtatggcctacatgccacttacgttttaagttatttaggaacacaaaggacagacaaaaaagccatatgcacatgcctcattttctcttatttttgatctatctagtaattcttttgctgcctgtctcttctccattttccttcttcttttttaagcatttttcatattcttcactgtcttctatttggtcttgattaggtgcatctatctcttcgctctgtcttccacaaacaaaaattctgccttcagacatttggtgttagtatttcacactcagttctccctttttttacataaggattgagtttctttttatgatgattttacctttatagcaattttgaattttgcattctattgctagtattgattcaggtacaccattaagatacaacattctagaagtctattaccttaggagttaattaaacatgatatttgaagaataatgaaatgctttatagttgtttgaggcataacaatgtgtatttgttttactggatcatgttttgaactgactagggagggtagcacctgcctcagatagtaccaacaattctgtttcactgggtagtctaaaactagcttatagtttaacttaacttgttgtgtatgtgaatttagggatggaaactttttttcccctatttattctttgtttccttctgggaaaaaaccccacaaaaatcagcactcctttatggatacattggagcttttgaaagaattgtaaactctaggaaggggaaatatctgtgtcttgatttcttagttgccttgaaaatcatgtactgaactgtaaccgctaacttgactggatgaactagtttgcttgtgtgtagagagtgtattgcttcctcagatttcactgttttcatctccttttccatcttagtctttattccttaagaccaaaaactgtaatatcctttagaaatgctctagaagatctgtattgtgtagaatgatcatgtatttataaatattttacaagtttagattataaaatgaaaaagaaggtcatgtgttttggggggtattttgcatgttcggatttttttttcacttcaccgaacccttctgattctttcaaactattgccaggtagttgttagtgtttctaattggactcttaatatgaacttcaagaagctgttaccagttatcggctctgtcatctgaaattttaaccacttaatttaaagttacaattttagaatttgtttttgttgttttaccttaagaaacacaataaatcactgtttaaaaaagatctcaatttatataaagtactggaaaaaagctaagtaatttttagttctatctataatctccgtaggatgaattagaaataaattgtgatgaaaagaaattaactgcttatttatgaatctaatcatttagaaatgtctgagagtaacactgcattcttatagaaacaaagcacaaattgcattcaagctctgaattgattttttgcttggagctgttgttacagtagctgtaattttgctaccagaatgtcttaattttttaaatttgtttttatttctaagctcttggcaatgacaataattataattttaacatatcttcactgtagtcaacatgtagagtctgcttccctcattattgcattgctaaggcctttttaaaaagcttatgcttacataatatactcttttttatggacacgttatatgtttccaaatctgtgtattgtgatttttacatactaatgaatataaacaggtgattttaaaatattactgtgcttctttggttgaatgagctggtattgatgtaaaatactctgtcattgatggaccactacctgcagctaagcagtgagcagaatctccgggaaatgacttagtctggccacatgcatagcccatcttcataatgtcgcagcagaaggttctttgtggttaaaagttttaaagcctatttctttataggtaaccctctcaggtatatttacctggtagaaaaacatgtagattgtttctattacttaaatgttttaattggactgtagtttagaaattacaggaccagcttgttacagattatacactattctgttacttttatttctgaaacttaaaaacaataaattctttttctgtgtttctaggttagaacttttttattttattgcacactgaacagatactgttgcttattgaatattgtgtaaacccttctttggctttccttgcccattgcaatttgatttaagcctactagagccattgtatgtgacagctatattgtattacaaagtaaaaatatatgagtgtattgaaaacaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:27067 -> Molecular function: GO:0003725 [double-stranded RNA binding] evidence: TAS
GeneID:27067 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:27067 -> Biological process: GO:0006810 [transport] evidence: IEA
GeneID:27067 -> Cellular component: GO:0005730 [nucleolus] evidence: IEA
GeneID:27067 -> Cellular component: GO:0005783 [endoplasmic reticulum] evidence: IEA
GeneID:27067 -> Cellular component: GO:0005874 [microtubule] evidence: IEA
by
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