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2024-04-19 18:19:13, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_013283 2154 bp mRNA linear PRI 01-JUL-2013
DEFINITION Homo sapiens methionine adenosyltransferase II, beta (MAT2B),
transcript variant 1, mRNA.
ACCESSION NM_013283
VERSION NM_013283.4 GI:422010901
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2154)
AUTHORS Shafqat,N., Muniz,J.R., Pilka,E.S., Papagrigoriou,E., von Delft,F.,
Oppermann,U. and Yue,W.W.
TITLE Insight into S-adenosylmethionine biosynthesis from the crystal
structures of the human methionine adenosyltransferase catalytic
and regulatory subunits
JOURNAL Biochem. J. 452 (1), 27-36 (2013)
PUBMED 23425511
REMARK GeneRIF: The structure of MAT2B reveals a short-chain
dehydrogenase/reductase (SDR) core with specificity for the NADP/H
cofactor, and harbors the SDR catalytic triad.
REFERENCE 2 (bases 1 to 2154)
AUTHORS Nordgren,K.K., Peng,Y., Pelleymounter,L.L., Moon,I., Abo,R.,
Feng,Q., Eckloff,B., Yee,V.C., Wieben,E. and Weinshilboum,R.M.
TITLE Methionine adenosyltransferase 2A/2B and methylation: gene sequence
variation and functional genomics
JOURNAL Drug Metab. Dispos. 39 (11), 2135-2147 (2011)
PUBMED 21813468
REMARK GeneRIF: Coexpression of MAT2A and MAT2B in COS-1 cells resulted in
significantly increased MAT enzyme activity.
REFERENCE 3 (bases 1 to 2154)
AUTHORS Xia,M., Chen,Y., Wang,L.C., Zandi,E., Yang,H., Bemanian,S.,
Martinez-Chantar,M.L., Mato,J.M. and Lu,S.C.
TITLE Novel function and intracellular localization of methionine
adenosyltransferase 2beta splicing variants
JOURNAL J. Biol. Chem. 285 (26), 20015-20021 (2010)
PUBMED 20421296
REMARK GeneRIF: Data show MAT2beta variants reside mostly in the nucleus
and regulate HuR subcellular content to affect cell proliferation.
REFERENCE 4 (bases 1 to 2154)
AUTHORS Attia,R.R., Gardner,L.A., Mahrous,E., Taxman,D.J., Legros,L.,
Rowe,S., Ting,J.P., Geller,A. and Kotb,M.
TITLE Selective targeting of leukemic cell growth in vivo and in vitro
using a gene silencing approach to diminish S-adenosylmethionine
synthesis
JOURNAL J. Biol. Chem. 283 (45), 30788-30795 (2008)
PUBMED 18753136
REMARK GeneRIF: differences in malignant cell survival, effected by
MAT-IIbeta ablation, suggest that it may be possible to use this
approach to disadvantage leukemic cell survival in vivo with little
to no harm to normal cells.
REFERENCE 5 (bases 1 to 2154)
AUTHORS Wang,Q., Liu,Q.Y., Liu,Z.S., Qian,Q., Sun,Q. and Pan,D.Y.
TITLE Lentivirus mediated shRNA interference targeting MAT2B induces
growth-inhibition and apoptosis in hepatocelluar carcinoma
JOURNAL World J. Gastroenterol. 14 (29), 4633-4642 (2008)
PUBMED 18698677
REMARK GeneRIF: a switch in MAT expression in liver cancer was accompanied
by increasing expression of MAT2B
REFERENCE 6 (bases 1 to 2154)
AUTHORS Martinez-Chantar,M.L., Garcia-Trevijano,E.R., Latasa,M.U.,
Martin-Duce,A., Fortes,P., Caballeria,J., Avila,M.A. and Mato,J.M.
TITLE Methionine adenosyltransferase II beta subunit gene expression
provides a proliferative advantage in human hepatoma
JOURNAL Gastroenterology 124 (4), 940-948 (2003)
PUBMED 12671891
REFERENCE 7 (bases 1 to 2154)
AUTHORS LeGros,L., Halim,A.B., Chamberlin,M.E., Geller,A. and Kotb,M.
TITLE Regulation of the human MAT2B gene encoding the regulatory beta
subunit of methionine adenosyltransferase, MAT II
JOURNAL J. Biol. Chem. 276 (27), 24918-24924 (2001)
PUBMED 11337507
REFERENCE 8 (bases 1 to 2154)
AUTHORS LeGros,H.L. Jr., Halim,A.B., Geller,A.M. and Kotb,M.
TITLE Cloning, expression, and functional characterization of the beta
regulatory subunit of human methionine adenosyltransferase (MAT II)
JOURNAL J. Biol. Chem. 275 (4), 2359-2366 (2000)
PUBMED 10644686
REFERENCE 9 (bases 1 to 2154)
AUTHORS Kotb,M., Mudd,S.H., Mato,J.M., Geller,A.M., Kredich,N.M., Chou,J.Y.
and Cantoni,G.L.
TITLE Consensus nomenclature for the mammalian methionine
adenosyltransferase genes and gene products
JOURNAL Trends Genet. 13 (2), 51-52 (1997)
PUBMED 9055605
REFERENCE 10 (bases 1 to 2154)
AUTHORS Okada,G., Teraoka,H. and Tsukada,K.
TITLE Multiple species of mammalian S-adenosylmethionine synthetase.
Partial purification and characterization
JOURNAL Biochemistry 20 (4), 934-940 (1981)
PUBMED 7213623
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from DA146198.1, AK312365.1,
AK096178.1 and HY366761.1.
On Nov 20, 2012 this sequence version replaced gi:33519456.
Summary: The protein encoded by this gene belongs to the methionine
adenosyltransferase (MAT) family. MAT catalyzes the biosynthesis of
S-adenosylmethionine from methionine and ATP. This protein is the
regulatory beta subunit of MAT. Alternative splicing results in
multiple transcript variants encoding different isoforms. [provided
by RefSeq, Nov 2012].
Transcript Variant: This variant (1) encodes the longer isoform
(1).
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: AL136664.1, BC093030.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025081, ERS025082 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: full length.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-51 DA146198.1 1-51
52-1164 AK312365.1 1-1113
1165-1950 AK096178.1 2425-3210
1951-2154 HY366761.1 1-204 c
FEATURES Location/Qualifiers
source 1..2154
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="5"
/map="5q34-q35"
gene 1..2154
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/note="methionine adenosyltransferase II, beta"
/db_xref="GeneID:27430"
/db_xref="HGNC:6905"
/db_xref="HPRD:05701"
/db_xref="MIM:605527"
exon 1..222
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/inference="alignment:Splign:1.39.8"
variation 54
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/replace="c"
/replace="t"
/db_xref="dbSNP:78092707"
variation 55
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/replace="c"
/replace="t"
/db_xref="dbSNP:372227393"
variation 113
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/replace="c"
/replace="t"
/db_xref="dbSNP:372800926"
variation 114
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/replace="c"
/replace="t"
/db_xref="dbSNP:375723333"
variation 116
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/replace="a"
/replace="g"
/db_xref="dbSNP:367719052"
variation 130
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/replace="a"
/replace="c"
/db_xref="dbSNP:200516708"
variation 131
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/replace="a"
/replace="g"
/db_xref="dbSNP:372087171"
misc_feature 133..135
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/note="upstream in-frame stop codon"
variation 141
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/replace="c"
/replace="t"
/db_xref="dbSNP:375373757"
variation 154
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/replace="a"
/replace="g"
/db_xref="dbSNP:369711301"
CDS 160..1164
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/EC_number="2.5.1.6"
/note="isoform 1 is encoded by transcript variant 1; beta
regulatory subunit of methionine adenosyltransferase;
short chain dehydrogenase/reductase family 23E, member 1;
dTDP-4-keto-6-deoxy-D-glucose 4-reductase; methionine
adenosyltransferase 2 subunit beta; putative protein
product of Nbla02999; MAT II beta; putative
dTDP-4-keto-6-deoxy-D-glucose 4-reductase"
/codon_start=1
/product="methionine adenosyltransferase 2 subunit beta
isoform 1"
/protein_id="NP_037415.1"
/db_xref="GI:11034825"
/db_xref="CCDS:CCDS4365.1"
/db_xref="GeneID:27430"
/db_xref="HGNC:6905"
/db_xref="HPRD:05701"
/db_xref="MIM:605527"
/translation="
MVGREKELSIHFVPGSCRLVEEEVNIPNRRVLVTGATGLLGRAVHKEFQQNNWHAVGCGFRRARPKFEQVNLLDSNAVHHIIHDFQPHVIVHCAAERRPDVVENQPDAASQLNVDASGNLAKEAAAVGAFLIYISSDYVFDGTNPPYREEDIPAPLNLYGKTKLDGEKAVLENNLGAAVLRIPILYGEVEKLEESAVTVMFDKVQFSNKSANMDHWQQRFPTHVKDVATVCRQLAEKRMLDPSIKGTFHWSGNEQMTKYEMACAIADAFNLPSSHLRPITDSPVLGAQRPRNAQLDCSKLETLGIGQRTPFRIGIKESLWPFLIDKRWRQTVFH
"
misc_feature 247..1107
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/note="dTDP-6-deoxy-L-lyxo-4-hexulose reductase and
related proteins, extended (e) SDRs; Region:
dTDP_HR_like_SDR_e; cd05254"
/db_xref="CDD:187564"
misc_feature 250..1128
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/note="RmlD substrate binding domain; Region:
RmlD_sub_bind; pfam04321"
/db_xref="CDD:113104"
misc_feature order(262..264,268..279,334..339,367..378,436..444,
448..450,493..495,559..567,634..636,646..648,703..714)
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/note="NADP binding site [chemical binding]; other site"
/db_xref="CDD:187564"
misc_feature order(496..498,565..567,634..636,646..648)
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/note="active site"
/db_xref="CDD:187564"
misc_feature order(565..567,634..636,709..711,757..759,796..798,
814..816)
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/note="putative substrate binding site [chemical binding];
other site"
/db_xref="CDD:187564"
variation 187
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/replace="a"
/replace="g"
/db_xref="dbSNP:199974025"
variation 220
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/replace="a"
/replace="g"
/db_xref="dbSNP:71599703"
exon 223..417
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/inference="alignment:Splign:1.39.8"
STS 237..353
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/standard_name="D5S1942"
/db_xref="UniSTS:154273"
variation 241
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/replace="a"
/replace="t"
/db_xref="dbSNP:370620878"
variation 273
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/replace="a"
/replace="g"
/db_xref="dbSNP:375538961"
variation 287
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/replace="c"
/replace="t"
/db_xref="dbSNP:376756318"
variation 307
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/replace="c"
/replace="g"
/db_xref="dbSNP:148822569"
variation 320
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/replace="a"
/replace="t"
/db_xref="dbSNP:369618222"
variation 387
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/replace="c"
/replace="t"
/db_xref="dbSNP:186526604"
variation 390
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/replace="a"
/replace="g"
/db_xref="dbSNP:143459228"
variation 406
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/replace="a"
/replace="c"
/db_xref="dbSNP:201956239"
variation 411
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/replace="c"
/replace="t"
/db_xref="dbSNP:370330528"
exon 418..532
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/inference="alignment:Splign:1.39.8"
variation 420
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/replace="a"
/replace="c"
/db_xref="dbSNP:148055585"
variation 492
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/replace="a"
/replace="g"
/db_xref="dbSNP:113548741"
variation 522
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/replace="a"
/replace="t"
/db_xref="dbSNP:141130487"
exon 533..685
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/inference="alignment:Splign:1.39.8"
variation 537
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/replace="c"
/replace="t"
/db_xref="dbSNP:144747113"
variation 538
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/replace="a"
/replace="g"
/db_xref="dbSNP:201068474"
variation 588
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/replace="a"
/replace="c"
/db_xref="dbSNP:372864990"
variation 589
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/replace="a"
/replace="g"
/db_xref="dbSNP:138673581"
variation 627
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/replace="a"
/replace="g"
/db_xref="dbSNP:375829232"
variation 644
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/replace="c"
/replace="t"
/db_xref="dbSNP:150850594"
variation 666
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/replace="c"
/replace="t"
/db_xref="dbSNP:183216928"
variation 684
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/replace="a"
/replace="g"
/db_xref="dbSNP:11546512"
exon 686..879
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/inference="alignment:Splign:1.39.8"
variation 688
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/replace="g"
/replace="t"
/db_xref="dbSNP:185174859"
variation 693
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/replace="c"
/replace="t"
/db_xref="dbSNP:371182015"
variation 714
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/replace="g"
/replace="t"
/db_xref="dbSNP:375446953"
variation 730
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/replace="a"
/replace="t"
/db_xref="dbSNP:57377425"
variation 736
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/replace="a"
/replace="g"
/db_xref="dbSNP:200525612"
variation 745
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/replace="c"
/replace="g"
/db_xref="dbSNP:201528924"
variation 758
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/replace="c"
/replace="t"
/db_xref="dbSNP:367745735"
variation 797
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/replace="c"
/replace="t"
/db_xref="dbSNP:149558527"
variation 812
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/replace="a"
/replace="g"
/db_xref="dbSNP:144243962"
variation 828
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/replace="c"
/replace="t"
/db_xref="dbSNP:201730499"
variation 852
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/replace="c"
/replace="t"
/db_xref="dbSNP:199601793"
exon 880..993
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/inference="alignment:Splign:1.39.8"
variation 889
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/replace="a"
/replace="g"
/db_xref="dbSNP:369683567"
variation 904
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/replace="a"
/replace="c"
/db_xref="dbSNP:373467119"
variation 917
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/replace="a"
/replace="g"
/db_xref="dbSNP:140996665"
variation 925
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/replace="a"
/replace="g"
/db_xref="dbSNP:368945288"
variation 945
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/replace="a"
/replace="t"
/db_xref="dbSNP:372671147"
variation 964
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/replace="g"
/replace="t"
/db_xref="dbSNP:200867979"
variation 973
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/replace="c"
/replace="t"
/db_xref="dbSNP:77428501"
exon 994..2154
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/inference="alignment:Splign:1.39.8"
variation 995
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/replace="g"
/replace="t"
/db_xref="dbSNP:201204381"
variation 997
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/replace="a"
/replace="g"
/db_xref="dbSNP:376794098"
variation 1012
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/replace="c"
/replace="g"
/replace="t"
/db_xref="dbSNP:77437261"
variation 1023
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/replace="a"
/replace="g"
/db_xref="dbSNP:187556859"
variation 1025
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/replace="a"
/replace="g"
/db_xref="dbSNP:147499303"
variation 1029
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/replace="a"
/replace="g"
/db_xref="dbSNP:140070929"
variation 1036
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/replace="a"
/replace="g"
/db_xref="dbSNP:17849948"
variation 1064
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/replace="c"
/replace="t"
/db_xref="dbSNP:80145956"
variation 1096
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/replace="a"
/replace="t"
/db_xref="dbSNP:368383130"
variation 1122
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/replace="a"
/replace="t"
/db_xref="dbSNP:199689662"
variation 1130
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/replace="c"
/replace="t"
/db_xref="dbSNP:192771488"
variation 1165..1168
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/replace=""
/replace="ttta"
/db_xref="dbSNP:376171593"
variation 1183
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/replace=""
/replace="t"
/db_xref="dbSNP:200442777"
variation 1204
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/replace="a"
/replace="g"
/db_xref="dbSNP:201566984"
variation 1216
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/replace="a"
/replace="g"
/db_xref="dbSNP:376358346"
variation 1224
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/replace=""
/replace="t"
/db_xref="dbSNP:35274545"
variation 1269
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/replace="c"
/replace="t"
/db_xref="dbSNP:182987686"
variation 1305
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/replace="a"
/replace="g"
/db_xref="dbSNP:188430776"
variation 1343..1344
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/replace=""
/replace="c"
/db_xref="dbSNP:35541788"
variation 1405
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/replace="a"
/replace="g"
/db_xref="dbSNP:191819378"
variation 1439
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/replace="c"
/replace="t"
/db_xref="dbSNP:11546511"
STS 1575..1763
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/standard_name="RH93678"
/db_xref="UniSTS:89867"
STS 1736..1856
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/standard_name="STS-D25599"
/db_xref="UniSTS:73833"
variation 1755
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/replace="c"
/replace="t"
/db_xref="dbSNP:372905622"
variation 1764
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/replace="a"
/replace="g"
/db_xref="dbSNP:141380012"
variation 1862
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/replace="c"
/replace="t"
/db_xref="dbSNP:184421743"
variation 1866
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/replace="a"
/replace="t"
/db_xref="dbSNP:143399168"
variation 2079
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/replace="a"
/replace="t"
/db_xref="dbSNP:189130444"
variation 2106..2110
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/replace=""
/replace="aaaac"
/db_xref="dbSNP:150449376"
variation 2107
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/replace="a"
/replace="c"
/db_xref="dbSNP:200172118"
variation 2110
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/replace="c"
/replace="t"
/db_xref="dbSNP:200926033"
variation 2111
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/replace="a"
/replace="c"
/db_xref="dbSNP:1129940"
polyA_signal 2113..2118
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
variation 2135
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/replace="c"
/replace="g"
/db_xref="dbSNP:192468905"
polyA_site 2137
/gene="MAT2B"
/gene_synonym="MAT-II; MATIIbeta; Nbla02999; SDR23E1; TGR"
/note="The 3' most polyA site has not been determined.
This is a major internal polyA site."
ORIGIN
aatcaacgggcgcggctatggcagcggaagccggaagcggcgagcggggtcgttctgggcctaggggaggcgggccgagggcgtctgagctgaggcccgcgtcgatcctgggttggaggaggtggcggccgctgaggctgcggcgtgaagacggcgggcatggtggggcgggagaaagagctctctatacactttgttcccgggagctgtcggctggtggaggaggaagttaacatccctaataggagggttctggttactggtgccactgggcttcttggcagagctgtacacaaagaatttcagcagaataattggcatgcagttggctgtggtttcagaagagcaagaccaaaatttgaacaggttaatctgttggattctaatgcagttcatcacatcattcatgattttcagccccatgttatagtacattgtgcagcagagagaagaccagatgttgtagaaaatcagccagatgctgcctctcaacttaatgtggatgcttctgggaatttagcaaaggaagcagctgctgttggagcatttctcatctacattagctcagattatgtatttgatggaacaaatccaccttacagagaggaagacataccagctcccctaaatttgtatggcaaaacaaaattagatggagaaaaggctgtcctggagaacaatctaggagctgctgttttgaggattcctattctgtatggggaagttgaaaagctcgaagaaagtgctgtgactgttatgtttgataaagtgcagttcagcaacaagtcagcaaacatggatcactggcagcagaggttccccacacatgtcaaagatgtggccactgtgtgccggcagctagcagagaagagaatgctggatccatcaattaagggaacctttcactggtctggcaatgaacagatgactaagtatgaaatggcatgtgcaattgcagatgccttcaacctccccagcagtcacttaagacctattactgacagccctgtcctaggagcacaacgtccgagaaatgctcagcttgactgctccaaattggagaccttgggcattggccaacgaacaccatttcgaattggaatcaaagaatcactttggcctttcctcattgacaagagatggagacaaacggtctttcattagtttatttgtgttgggttcttttttttttttaaatgaaaagtatagtatgtggcactttttaaagaacaaaggaaatagttttgtatgagtactttaattgtgactcttaggatctttcaggtaaatgatgctcttgcactagtgaaattgtctaaagaaactaaagggcagtcatgccctgtttgcagtaatttttctttttatcattttgtttgtcctggctaaacttggagtttgagtatagtaaattatgatccttaaatatttgagagtcaggatgaagcagatctgctgtagacttttcagatgaaattgttcattctcgtaacctccatattttcaggatttttgaagctgttgaccttttcatgttgattattttaaattgtgtgaaatagtataaaaatcattggtgttcattatttgctttgcctgagctcagatcaaaatgtttgaagaaaggaactttatttttgcaagttacgtacagtttttatgcttgagatatttcaacatgttatgtatattggaacttctacagcttgatgcctcctgcttttatagcagtttatggggagcacttgaaagagcgtgtgtacatgtattttttttctaggcaaacattgaatgcaaacgtgtatttttttaatataaatatataactgtccttttcatcccatgttgccgctaagtgatatttcatatgtgtggttatactcataataatgggccttgtaagtcttttcaccattcatgaataataataaatatgtactgctggcatgtaatgcttagttttcttgtatttacttctttttttaaatgtaaggaccaaacttctaaactaattgttcttttgttgctttaatttttaaaaattacattcttctgatgtaacatgtgatacatacaaaagaatatagtttaatatgtattgaaataaaacacaataaaattaacacttgatccagaatgttaacttaccacccc
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:27430 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:27430 -> Molecular function: GO:0008831 [dTDP-4-dehydrorhamnose reductase activity] evidence: IEA
GeneID:27430 -> Molecular function: GO:0048270 [methionine adenosyltransferase regulator activity] evidence: IDA
GeneID:27430 -> Biological process: GO:0000096 [sulfur amino acid metabolic process] evidence: TAS
GeneID:27430 -> Biological process: GO:0006556 [S-adenosylmethionine biosynthetic process] evidence: IDA
GeneID:27430 -> Biological process: GO:0006556 [S-adenosylmethionine biosynthetic process] evidence: IEA
GeneID:27430 -> Biological process: GO:0006730 [one-carbon metabolic process] evidence: IEA
GeneID:27430 -> Biological process: GO:0006805 [xenobiotic metabolic process] evidence: TAS
GeneID:27430 -> Biological process: GO:0032259 [methylation] evidence: TAS
GeneID:27430 -> Biological process: GO:0034641 [cellular nitrogen compound metabolic process] evidence: TAS
GeneID:27430 -> Biological process: GO:0044281 [small molecule metabolic process] evidence: TAS
GeneID:27430 -> Biological process: GO:0045226 [extracellular polysaccharide biosynthetic process] evidence: IEA
GeneID:27430 -> Cellular component: GO:0005622 [intracellular] evidence: IC
GeneID:27430 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
GeneID:27430 -> Cellular component: GO:0005739 [mitochondrion] evidence: IEA
GeneID:27430 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
GeneID:27430 -> Cellular component: GO:0048269 [methionine adenosyltransferase complex] evidence: IDA
ANNOTATIONS from NCBI Entrez Gene (20130726):
NP_037415 -> EC 2.5.1.6
by
@meso_cacase at
DBCLS
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