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2024-04-16 15:45:18, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_007174 8582 bp mRNA linear PRI 17-APR-2013
DEFINITION Homo sapiens citron (rho-interacting, serine/threonine kinase 21)
(CIT), transcript variant 2, mRNA.
ACCESSION NM_007174
VERSION NM_007174.2 GI:332801083
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 8582)
AUTHORS Serres,M.P., Kossatz,U., Chi,Y., Roberts,J.M., Malek,N.P. and
Besson,A.
TITLE p27(Kip1) controls cytokinesis via the regulation of citron kinase
activation
JOURNAL J. Clin. Invest. 122 (3), 844-858 (2012)
PUBMED 22293177
REMARK GeneRIF: p27 has a role in cytokinesis via the regulation of
citron-K activity
REFERENCE 2 (bases 1 to 8582)
AUTHORS Whitworth,H., Bhadel,S., Ivey,M., Conaway,M., Spencer,A.,
Hernan,R., Holemon,H. and Gioeli,D.
TITLE Identification of kinases regulating prostate cancer cell growth
using an RNAi phenotypic screen
JOURNAL PLoS ONE 7 (6), E38950 (2012)
PUBMED 22761715
REMARK GeneRIF: High CIT expression is associated with prostate cancer.
REFERENCE 3 (bases 1 to 8582)
AUTHORS Gai,M., Camera,P., Dema,A., Bianchi,F., Berto,G., Scarpa,E.,
Germena,G. and Di Cunto,F.
TITLE Citron kinase controls abscission through RhoA and anillin
JOURNAL Mol. Biol. Cell 22 (20), 3768-3778 (2011)
PUBMED 21849473
REMARK GeneRIF: CIT-K is a crucial abscission regulator that may promote
midbody stability through active RhoA and anillin.
REFERENCE 4 (bases 1 to 8582)
AUTHORS Fu,Y., Huang,J., Wang,K.S., Zhang,X. and Han,Z.G.
TITLE RNA interference targeting CITRON can significantly inhibit the
proliferation of hepatocellular carcinoma cells
JOURNAL Mol. Biol. Rep. 38 (2), 693-702 (2011)
PUBMED 20369383
REMARK GeneRIF: CITRON has a role in proliferation of hepatocellular
carcinoma cells
REFERENCE 5 (bases 1 to 8582)
AUTHORS Nicodemus,K.K., Callicott,J.H., Higier,R.G., Luna,A., Nixon,D.C.,
Lipska,B.K., Vakkalanka,R., Giegling,I., Rujescu,D., St Clair,D.,
Muglia,P., Shugart,Y.Y. and Weinberger,D.R.
TITLE Evidence of statistical epistasis between DISC1, CIT and NDEL1
impacting risk for schizophrenia: biological validation with
functional neuroimaging
JOURNAL Hum. Genet. 127 (4), 441-452 (2010)
PUBMED 20084519
REMARK GeneRIF: Evidence of statistical epistasis between DISC1, CIT and
NDEL1 impacting risk for schizophrenia: biological validation with
functional neuroimaging.
GeneRIF: Observational study of gene-disease association and
gene-gene interaction. (HuGE Navigator)
Erratum:[Hum Genet. 2010 Apr;127(4):453-4]
REFERENCE 6 (bases 1 to 8582)
AUTHORS Gruneberg,U., Neef,R., Li,X., Chan,E.H., Chalamalasetty,R.B.,
Nigg,E.A. and Barr,F.A.
TITLE KIF14 and citron kinase act together to promote efficient
cytokinesis
JOURNAL J. Cell Biol. 172 (3), 363-372 (2006)
PUBMED 16431929
REMARK GeneRIF: During cytokinesis, the localization of KIF14 and citron
kinase to the central spindle and midbody is codependent, and they
form a complex depending on the activation state of citron kinase.
REFERENCE 7 (bases 1 to 8582)
AUTHORS Lyons-Warren,A., Chang,J.J., Balkissoon,R., Kamiya,A., Garant,M.,
Nurnberger,J., Scheftner,W., Reich,T., McMahon,F., Kelsoe,J.,
Gershon,E., Coryell,W., Byerley,W., Berrettini,W., Depaulo,R.,
McInnis,M. and Sawa,A.
TITLE Evidence of association between bipolar disorder and Citron on
chromosome 12q24
JOURNAL Mol. Psychiatry 10 (9), 807-809 (2005)
PUBMED 15983625
REMARK GeneRIF: Single nucleotide polymorphisms associated with bipolar
disorder.
Erratum:[Mol Psychiatry. 2006 Jun;11(6):612]
REFERENCE 8 (bases 1 to 8582)
AUTHORS Husi,H., Ward,M.A., Choudhary,J.S., Blackstock,W.P. and Grant,S.G.
TITLE Proteomic analysis of NMDA receptor-adhesion protein signaling
complexes
JOURNAL Nat. Neurosci. 3 (7), 661-669 (2000)
PUBMED 10862698
REFERENCE 9 (bases 1 to 8582)
AUTHORS Zhang,W., Vazquez,L., Apperson,M. and Kennedy,M.B.
TITLE Citron binds to PSD-95 at glutamatergic synapses on inhibitory
neurons in the hippocampus
JOURNAL J. Neurosci. 19 (1), 96-108 (1999)
PUBMED 9870942
REFERENCE 10 (bases 1 to 8582)
AUTHORS Madaule,P., Furuyashiki,T., Reid,T., Ishizaki,T., Watanabe,G.,
Morii,N. and Narumiya,S.
TITLE A novel partner for the GTP-bound forms of rho and rac
JOURNAL FEBS Lett. 377 (2), 243-248 (1995)
PUBMED 8543060
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from AY681966.1 and AY257469.1.
On May 13, 2011 this sequence version replaced gi:32698687.
Summary: This gene encodes a serine/threonine-protein kinase that
functions in cell division. Together with the kinesin KIF14, this
protein localizes to the central spindle and midbody, and functions
to promote efficient cytokinesis. This protein is involved in
central nervous system development. Polymorphisms in this gene are
associated with bipolar disorder and risk for schizophrenia.
Alternative splicing results in multiple transcript variants.
[provided by RefSeq, Aug 2011].
Transcript Variant: This variant (2) lacks an in-frame exon in the
coding region, compared to variant 1. This results in a shorter
protein (isoform 2), compared to isoform 1.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: AY257469.1 [ECO:0000332]
RNAseq introns :: mixed/partial sample support
ERS025081, ERS025082 [ECO:0000350]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-3 AY681966.1 1-3
4-8579 AY257469.1 1-8576
8580-8582 AY681966.1 8705-8707
FEATURES Location/Qualifiers
source 1..8582
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="12"
/map="12q24"
gene 1..8582
/gene="CIT"
/gene_synonym="CRIK; STK21"
/note="citron (rho-interacting, serine/threonine kinase
21)"
/db_xref="GeneID:11113"
/db_xref="HGNC:1985"
/db_xref="HPRD:09289"
/db_xref="MIM:605629"
exon 1..43
/gene="CIT"
/gene_synonym="CRIK; STK21"
/inference="alignment:Splign:1.39.8"
exon 44..152
/gene="CIT"
/gene_synonym="CRIK; STK21"
/inference="alignment:Splign:1.39.8"
CDS 57..6140
/gene="CIT"
/gene_synonym="CRIK; STK21"
/EC_number="2.7.11.1"
/note="isoform 2 is encoded by transcript variant 2;
serine/threonine-protein kinase 21"
/codon_start=1
/product="citron Rho-interacting kinase isoform 2"
/protein_id="NP_009105.1"
/db_xref="GI:32698688"
/db_xref="CCDS:CCDS9192.1"
/db_xref="GeneID:11113"
/db_xref="HGNC:1985"
/db_xref="HPRD:09289"
/db_xref="MIM:605629"
/translation="
MLKFKYGARNPLDAGAAEPIASRASRLNLFFQGKPPFMTQQQMSPLSREGILDALFVLFEECSQPALMKIKHVSNFVRKYSDTIAELQELQPSAKDFEVRSLVGCGHFAEVQVVREKATGDIYAMKVMKKKALLAQEQVSFFEEERNILSRSTSPWIPQLQYAFQDKNHLYLVMEYQPGGDLLSLLNRYEDQLDENLIQFYLAELILAVHSVHLMGYVHRDIKPENILVDRTGHIKLVDFGSAAKMNSNKMVNAKLPIGTPDYMAPEVLTVMNGDGKGTYGLDCDWWSVGVIAYEMIYGRSPFAEGTSARTFNNIMNFQRFLKFPDDPKVSSDFLDLIQSLLCGQKERLKFEGLCCHPFFSKIDWNNIRNSPPPFVPTLKSDDDTSNFDEPEKNSWVSSSPCQLSPSGFSGEELPFVGFSYSKALGILGRSESVVSGLDSPAKTSSMEKKLLIKSKELQDSQDKCHKMEQEMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQDLATYITECSSLKRSLEQARMEVSQEDDKALQLLHDIREQSRKLQEIKEQEYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELRESRLAAEEFKRKATECQHKLLKAKDQGKPEVGEYAKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLQNREDSSEGIRKKLVEAEELEEKHREAQVSAQHLEVHLKQKEQHYEEKIKVLDNQIKKDLADKETLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKNRLLELETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTCTMLEEQVMDLEALNDELLEKERQWEAWRSVLGDEKSQFECRVRELQRMLDTEKQSRARADQRITESRQVVELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQMDLQKNHIFRLTQGLQEALDRADLLKTERSDLEYQLENIQVLYSHEKVKMEGTISQQTKLIDFLQAKMDQPAKKKKGLFSRRKEDPALPTQVPLQYNELKLALEKEKARCAELEEALQKTRIELRSAREEAAHRKATDHPHPSTPATARQQIAMSAIVRSPEHQPSAMSLLAPPSSRRKESSTPEEFSRRLKERMHHNIPHRFNVGLNMRATKCAVCLDTVHFGRQASKCLECQVMCHPKCSTCLPATCGLPAEYATHFTEAFCRDKMNSPGLQTKEPSSSLHLEGWMKVPRNNKRGQQGWDRKYIVLEGSKVLIYDNEAREAGQRPVEEFELCLPDGDVSIHGAVGASELANTAKADVPYILKMESHPHTTCWPGRTLYLLAPSFPDKQRWVTALESVVAGGRVSREKAEADAKLLGNSLLKLEGDDRLDMNCTLPFSDQVVLVGTEEGLYALNVLKNSLTHVPGIGAVFQIYIIKDLEKLLMIAGEERALCLVDVKKVKQSLAQSHLPAQPDISPNIFEAVKGCHLFGAGKIENGLCICAAMPSKVVILRYNENLSKYCIRKEIETSEPCSCIHFTNYSILIGTNKFYEIDMKQYTLEEFLDKNDHSLAPAVFAASSNSFPVSIVQVNSAGQREEYLLCFHEFGVFVDSYGRRSRTDDLKWSRLPLAFAYREPYLFVTHFNSLEVIEIQARSSAGTPARAYLDIPNPRYLGPAISSGAIYLASSYQDKLRVICCKGNLVKESGTEHHRGPSTSRSSPNKRGPPTYNEHITKRVASSPAPPEGPSHPREPSTPHRYREGRTELRRDKSPGRPLEREKSPGRMLSTRRERSPGRLFEDSSRGRLPAGAVRTPLSQVNKVWDQSSV
"
misc_feature 339..1322
/gene="CIT"
/gene_synonym="CRIK; STK21"
/note="Catalytic domain of the Protein Serine/Threonine
Kinase, Citron Rho-interacting kinase; Region: STKc_CRIK;
cd05601"
/db_xref="CDD:173692"
misc_feature 345..1136
/gene="CIT"
/gene_synonym="CRIK; STK21"
/note="Serine/Threonine protein kinases, catalytic domain;
Region: S_TKc; smart00220"
/db_xref="CDD:197582"
misc_feature order(363..377,387..389,426..428,432..434,528..530,
576..581,585..587,597..599,603..605,717..719,723..725,
729..734,738..740,768..773,780..782,825..842,939..941,
957..959,966..968)
/gene="CIT"
/gene_synonym="CRIK; STK21"
/note="active site"
/db_xref="CDD:173692"
misc_feature order(363..368,387..389,426..428,576..587,597..599,
729..731,738..740,768..773)
/gene="CIT"
/gene_synonym="CRIK; STK21"
/note="ATP binding site [chemical binding]; other site"
/db_xref="CDD:173692"
misc_feature order(375..377,597..599,603..605,717..719,723..725,
729..731,780..782,825..842,939..941,957..959,966..968)
/gene="CIT"
/gene_synonym="CRIK; STK21"
/note="substrate binding site [chemical binding]; other
site"
/db_xref="CDD:173692"
misc_feature 768..842
/gene="CIT"
/gene_synonym="CRIK; STK21"
/note="activation loop (A-loop); other site"
/db_xref="CDD:173692"
misc_feature 1302..1319
/gene="CIT"
/gene_synonym="CRIK; STK21"
/note="hydrophobic motif (HM); other site"
/db_xref="CDD:173692"
misc_feature 1353..1355
/gene="CIT"
/gene_synonym="CRIK; STK21"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(O14578.2); phosphorylation site"
misc_feature 1374..1376
/gene="CIT"
/gene_synonym="CRIK; STK21"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(O14578.2); phosphorylation site"
misc_feature 1374..1376
/gene="CIT"
/gene_synonym="CRIK; STK21"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 3327..3962
/gene="CIT"
/gene_synonym="CRIK; STK21"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (O14578.2);
Region: Interaction with Rho/Rac"
misc_feature 4143..4289
/gene="CIT"
/gene_synonym="CRIK; STK21"
/note="Protein kinase C conserved region 1 (C1) .
Cysteine-rich zinc binding domain. Some members of this
domain family bind phorbol esters and diacylglycerol, some
are reported to bind RasGTP. May occur in tandem
arrangement. Diacylglycerol (DAG) is a second...; Region:
C1; cd00029"
/db_xref="CDD:28911"
misc_feature order(4143..4145,4182..4184,4191..4193,4230..4232,
4239..4241,4254..4256,4263..4265,4287..4289)
/gene="CIT"
/gene_synonym="CRIK; STK21"
/note="zinc binding sites [ion binding]; other site"
/db_xref="CDD:28911"
misc_feature order(4164..4166,4173..4178,4203..4205,4206..4220)
/gene="CIT"
/gene_synonym="CRIK; STK21"
/note="putative DAG/PE binding site; other site"
/db_xref="CDD:28911"
misc_feature order(4173..4175,4179..4181)
/gene="CIT"
/gene_synonym="CRIK; STK21"
/note="putative RAS interaction site [polypeptide
binding]; other site"
/db_xref="CDD:28911"
misc_feature 4392..4730
/gene="CIT"
/gene_synonym="CRIK; STK21"
/note="Pleckstrin homology-like domain; Region: PH-like;
cl00273"
/db_xref="CDD:206947"
misc_feature order(4392..4415,4446..4466,4473..4493,4563..4571,
4626..4637,4674..4688,4713..4730)
/gene="CIT"
/gene_synonym="CRIK; STK21"
/note="PH-like core; other site"
/db_xref="CDD:176275"
misc_feature 4833..5723
/gene="CIT"
/gene_synonym="CRIK; STK21"
/note="Domain found in NIK1-like kinases, mouse citron and
yeast ROM1, ROM2; Region: CNH; smart00036"
/db_xref="CDD:197482"
misc_feature 5217..5219
/gene="CIT"
/gene_synonym="CRIK; STK21"
/experiment="experimental evidence, no additional details
recorded"
/note="N6-acetyllysine; propagated from
UniProtKB/Swiss-Prot (O14578.2); acetylation site"
misc_feature 5913..5930
/gene="CIT"
/gene_synonym="CRIK; STK21"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (O14578.2);
Region: SH3-binding (Potential)"
misc_feature 5967..5969
/gene="CIT"
/gene_synonym="CRIK; STK21"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 6033..6035
/gene="CIT"
/gene_synonym="CRIK; STK21"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
exon 153..294
/gene="CIT"
/gene_synonym="CRIK; STK21"
/inference="alignment:Splign:1.39.8"
exon 295..470
/gene="CIT"
/gene_synonym="CRIK; STK21"
/inference="alignment:Splign:1.39.8"
exon 471..572
/gene="CIT"
/gene_synonym="CRIK; STK21"
/inference="alignment:Splign:1.39.8"
exon 573..715
/gene="CIT"
/gene_synonym="CRIK; STK21"
/inference="alignment:Splign:1.39.8"
exon 716..809
/gene="CIT"
/gene_synonym="CRIK; STK21"
/inference="alignment:Splign:1.39.8"
exon 810..1013
/gene="CIT"
/gene_synonym="CRIK; STK21"
/inference="alignment:Splign:1.39.8"
exon 1014..1167
/gene="CIT"
/gene_synonym="CRIK; STK21"
/inference="alignment:Splign:1.39.8"
exon 1168..1351
/gene="CIT"
/gene_synonym="CRIK; STK21"
/inference="alignment:Splign:1.39.8"
exon 1352..1457
/gene="CIT"
/gene_synonym="CRIK; STK21"
/inference="alignment:Splign:1.39.8"
exon 1458..1601
/gene="CIT"
/gene_synonym="CRIK; STK21"
/inference="alignment:Splign:1.39.8"
exon 1602..1721
/gene="CIT"
/gene_synonym="CRIK; STK21"
/inference="alignment:Splign:1.39.8"
exon 1722..1892
/gene="CIT"
/gene_synonym="CRIK; STK21"
/inference="alignment:Splign:1.39.8"
exon 1893..1943
/gene="CIT"
/gene_synonym="CRIK; STK21"
/inference="alignment:Splign:1.39.8"
exon 1944..1997
/gene="CIT"
/gene_synonym="CRIK; STK21"
/inference="alignment:Splign:1.39.8"
exon 1998..2138
/gene="CIT"
/gene_synonym="CRIK; STK21"
/inference="alignment:Splign:1.39.8"
exon 2139..2234
/gene="CIT"
/gene_synonym="CRIK; STK21"
/inference="alignment:Splign:1.39.8"
exon 2235..2351
/gene="CIT"
/gene_synonym="CRIK; STK21"
/inference="alignment:Splign:1.39.8"
exon 2352..2461
/gene="CIT"
/gene_synonym="CRIK; STK21"
/inference="alignment:Splign:1.39.8"
exon 2462..2636
/gene="CIT"
/gene_synonym="CRIK; STK21"
/inference="alignment:Splign:1.39.8"
exon 2637..2834
/gene="CIT"
/gene_synonym="CRIK; STK21"
/inference="alignment:Splign:1.39.8"
variation 2801
/gene="CIT"
/gene_synonym="CRIK; STK21"
/replace="a"
/replace="g"
/db_xref="dbSNP:904654"
variation 2810
/gene="CIT"
/gene_synonym="CRIK; STK21"
/replace="c"
/replace="t"
/db_xref="dbSNP:904655"
exon 2835..2888
/gene="CIT"
/gene_synonym="CRIK; STK21"
/inference="alignment:Splign:1.39.8"
exon 2889..3086
/gene="CIT"
/gene_synonym="CRIK; STK21"
/inference="alignment:Splign:1.39.8"
STS 3083..3197
/gene="CIT"
/gene_synonym="CRIK; STK21"
/standard_name="G29083"
/db_xref="UniSTS:47377"
exon 3087..3280
/gene="CIT"
/gene_synonym="CRIK; STK21"
/inference="alignment:Splign:1.39.8"
exon 3281..3416
/gene="CIT"
/gene_synonym="CRIK; STK21"
/inference="alignment:Splign:1.39.8"
exon 3417..3521
/gene="CIT"
/gene_synonym="CRIK; STK21"
/inference="alignment:Splign:1.39.8"
exon 3522..3662
/gene="CIT"
/gene_synonym="CRIK; STK21"
/inference="alignment:Splign:1.39.8"
exon 3663..3770
/gene="CIT"
/gene_synonym="CRIK; STK21"
/inference="alignment:Splign:1.39.8"
exon 3771..3933
/gene="CIT"
/gene_synonym="CRIK; STK21"
/inference="alignment:Splign:1.39.8"
exon 3934..4098
/gene="CIT"
/gene_synonym="CRIK; STK21"
/inference="alignment:Splign:1.39.8"
exon 4099..4236
/gene="CIT"
/gene_synonym="CRIK; STK21"
/inference="alignment:Splign:1.39.8"
exon 4237..4417
/gene="CIT"
/gene_synonym="CRIK; STK21"
/inference="alignment:Splign:1.39.8"
exon 4418..4509
/gene="CIT"
/gene_synonym="CRIK; STK21"
/inference="alignment:Splign:1.39.8"
exon 4510..4614
/gene="CIT"
/gene_synonym="CRIK; STK21"
/inference="alignment:Splign:1.39.8"
exon 4615..4784
/gene="CIT"
/gene_synonym="CRIK; STK21"
/inference="alignment:Splign:1.39.8"
exon 4785..4865
/gene="CIT"
/gene_synonym="CRIK; STK21"
/inference="alignment:Splign:1.39.8"
exon 4866..5001
/gene="CIT"
/gene_synonym="CRIK; STK21"
/inference="alignment:Splign:1.39.8"
exon 5002..5141
/gene="CIT"
/gene_synonym="CRIK; STK21"
/inference="alignment:Splign:1.39.8"
exon 5142..5234
/gene="CIT"
/gene_synonym="CRIK; STK21"
/inference="alignment:Splign:1.39.8"
exon 5235..5343
/gene="CIT"
/gene_synonym="CRIK; STK21"
/inference="alignment:Splign:1.39.8"
exon 5344..5472
/gene="CIT"
/gene_synonym="CRIK; STK21"
/inference="alignment:Splign:1.39.8"
exon 5473..5553
/gene="CIT"
/gene_synonym="CRIK; STK21"
/inference="alignment:Splign:1.39.8"
exon 5554..5632
/gene="CIT"
/gene_synonym="CRIK; STK21"
/inference="alignment:Splign:1.39.8"
exon 5633..5812
/gene="CIT"
/gene_synonym="CRIK; STK21"
/inference="alignment:Splign:1.39.8"
exon 5813..6116
/gene="CIT"
/gene_synonym="CRIK; STK21"
/inference="alignment:Splign:1.39.8"
exon 6117..8582
/gene="CIT"
/gene_synonym="CRIK; STK21"
/inference="alignment:Splign:1.39.8"
variation 7480
/gene="CIT"
/gene_synonym="CRIK; STK21"
/replace="a"
/replace="g"
/db_xref="dbSNP:3742046"
STS 7567..8450
/gene="CIT"
/gene_synonym="CRIK; STK21"
/standard_name="CIT_4577"
/db_xref="UniSTS:464470"
STS 8365..8506
/gene="CIT"
/gene_synonym="CRIK; STK21"
/standard_name="RH15678"
/db_xref="UniSTS:20886"
polyA_signal 8559..8564
/gene="CIT"
/gene_synonym="CRIK; STK21"
polyA_site 8581
/gene="CIT"
/gene_synonym="CRIK; STK21"
ORIGIN
ggcgcggggcggaacagatcgcagacctgggggttcgcagagccgccagtggggagatgttgaagttcaaatatggagcgcggaatcctttggatgctggtgctgctgaacccattgccagccgggcctccaggctgaatctgttcttccaggggaaaccaccctttatgactcaacagcagatgtctcctctttcccgagaagggatattagatgccctctttgttctctttgaagaatgcagtcagcctgctctgatgaagattaagcacgtgagcaactttgtccggaagtattccgacaccatagctgagttacaggagctccagccttcggcaaaggacttcgaagtcagaagtcttgtaggttgtggtcactttgctgaagtgcaggtggtaagagagaaagcaaccggggacatctatgctatgaaagtgatgaagaagaaggctttattggcccaggagcaggtttcattttttgaggaagagcggaacatattatctcgaagcacaagcccgtggatcccccaattacagtatgcctttcaggacaaaaatcacctttatctggtcatggaatatcagcctggaggggacttgctgtcacttttgaatagatatgaggaccagttagatgaaaacctgatacagttttacctagctgagctgattttggctgttcacagcgttcatctgatgggatacgtgcatcgagacatcaagcctgagaacattctcgttgaccgcacaggacacatcaagctggtggattttggatctgccgcgaaaatgaattcaaacaagatggtgaatgccaaactcccgattgggaccccagattacatggctcctgaagtgctgactgtgatgaacggggatggaaaaggcacctacggcctggactgtgactggtggtcagtgggcgtgattgcctatgagatgatttatgggagatcccccttcgcagagggaacctctgccagaaccttcaataacattatgaatttccagcggtttttgaaatttccagatgaccccaaagtgagcagtgactttcttgatctgattcaaagcttgttgtgcggccagaaagagagactgaagtttgaaggtctttgctgccatcctttcttctctaaaattgactggaacaacattcgtaactctcctccccccttcgttcccaccctcaagtctgacgatgacacctccaattttgatgaaccagagaagaattcgtgggtttcatcctctccgtgccagctgagcccctcaggcttctcgggtgaagaactgccgtttgtggggttttcgtacagcaaggcactggggattcttggtagatctgagtctgttgtgtcgggtctggactcccctgccaagactagctccatggaaaagaaacttctcatcaaaagcaaagagctacaagactctcaggacaagtgtcacaagatggagcaggaaatgacccggttacatcggagagtgtcagaggtggaggctgtgcttagtcagaaggaggtggagctgaaggcctctgagactcagagatccctcctggagcaggaccttgctacctacatcacagaatgcagtagcttaaagcgaagtttggagcaagcacggatggaggtgtcccaggaggatgacaaagcactgcagcttctccatgatatcagagagcagagccggaagctccaagaaatcaaagagcaggagtaccaggctcaagtggaagaaatgaggttgatgatgaatcagttggaagaggatcttgtctcagcaagaagacggagtgatctctacgaatctgagctgagagagtctcggcttgctgctgaagaattcaagcggaaagcgacagaatgtcagcataaactgttgaaggctaaggatcaagggaagcctgaagtgggagaatatgcgaaactggagaagatcaatgctgagcagcagctcaaaattcaggagctccaagagaaactggagaaggctgtaaaagccagcacggaggccaccgagctgctgcagaatatccgccaggcaaaggagcgagccgagagggagctggagaagctgcagaaccgagaggattcttctgaaggcatcagaaagaagctggtggaagctgaggagctcgaagagaaacatcgggaggcccaagtctcagcccagcacctagaagtgcacctgaaacagaaagagcagcactatgaggaaaagattaaagtgttggacaatcagataaagaaagacctggctgacaaggagacactggagaacatgatgcagagacacgaggaggaggcccatgagaagggcaaaattctcagcgaacagaaggcgatgatcaatgctatggattccaagatcagatccctggaacagaggattgtggaactgtctgaagccaataaacttgcagcaaatagcagtctttttacccaaaggaacatgaaggcccaagaagagatgatttctgaactcaggcaacagaaattttacctggagacacaggctgggaagttggaggcccagaaccgaaaactggaggagcagctggagaagatcagccaccaagaccacagtgacaagaatcggctgctggaactggagacaagattgcgggaggtcagtctagagcacgaggagcagaaactggagctcaagcgccagctcacagagctacagctctccctgcaggagcgcgagtcacagttgacagccctgcaggctgcacgggcggccctggagagccagcttcgccaggcgaagacagagctggaagagaccacagcagaagctgaagaggagatccaggcactcacggcacatagagatgaaatccagcgcaaatttgatgctcttcgtaacagctgtactgtaatcacagacctggaggagcagctaaaccagctgaccgaggacaacgctgaactcaacaaccaaaacttctacttgtccaaacaactcgatgaggcttctggcgccaacgacgagattgtacaactgcgaagtgaagtggaccatctccgccgggagatcacggaacgagagatgcagcttaccagccagaagcaaacgatggaggctctgaagaccacgtgcaccatgctggaggaacaggtcatggatttggaggccctaaacgatgagctgctagaaaaagagcggcagtgggaggcctggaggagcgtcctgggtgatgagaaatcccagtttgagtgtcgggttcgagagctgcagagaatgctggacaccgagaaacagagcagggcgagagccgatcagcggatcaccgagtctcgccaggtggtggagctggcagtgaaggagcacaaggctgagattctcgctctgcagcaggctctcaaagagcagaagctgaaggccgagagcctctctgacaagctcaatgacctggagaagaagcatgctatgcttgaaatgaatgcccgaagcttacagcagaagctggagactgaacgagagctcaaacagaggcttctggaagagcaagccaaattacagcagcagatggacctgcagaaaaatcacattttccgtctgactcaaggactgcaagaagctctagatcgggctgatctactgaagacagaaagaagtgacttggagtatcagctggaaaacattcaggttctctattctcatgaaaaggtgaaaatggaaggcactatttctcaacaaaccaaactcattgattttctgcaagccaaaatggaccaacctgctaaaaagaaaaagggtttatttagtcgacggaaagaggaccctgctttacccacacaggttcctctgcagtacaatgagctgaagctggccctggagaaggagaaagctcgctgtgcagagctagaggaagcccttcagaagacccgcatcgagctccggtccgcccgggaggaagctgcccaccgcaaagcaacggaccacccacacccatccacgccagccaccgcgaggcagcagatcgccatgtccgccatcgtgcggtcgccagagcaccagcccagtgccatgagcctgctggccccgccatccagccgcagaaaggagtcttcaactccagaggaatttagtcggcgtcttaaggaacgcatgcaccacaatattcctcaccgattcaacgtaggactgaacatgcgagccacaaagtgtgctgtgtgtctggataccgtgcactttggacgccaggcatccaaatgtctcgaatgtcaggtgatgtgtcaccccaagtgctccacgtgcttgccagccacctgcggcttgcctgctgaatatgccacacacttcaccgaggccttctgccgtgacaaaatgaactccccaggtctccagaccaaggagcccagcagcagcttgcacctggaagggtggatgaaggtgcccaggaataacaaacgaggacagcaaggctgggacaggaagtacattgtcctggagggatcaaaagtcctcatttatgacaatgaagccagagaagctggacagaggccggtggaagaatttgagctgtgccttcccgacggggatgtatctattcatggtgccgttggtgcttccgaactcgcaaatacagccaaagcagatgtcccatacatactgaagatggaatctcacccgcacaccacctgctggcccgggagaaccctctacttgctagctcccagcttccctgacaaacagcgctgggtcaccgccttagaatcagttgtcgcaggtgggagagtttctagggaaaaagcagaagctgatgctaaactgcttggaaactccctgctgaaactggaaggtgatgaccgtctagacatgaactgcacgctgcccttcagtgaccaggtggtgttggtgggcaccgaggaagggctctacgccctgaatgtcttgaaaaactccctaacccatgtcccaggaattggagcagtcttccaaatttatattatcaaggacctggagaagctactcatgatagcaggagaagagcgggcactgtgtcttgtggacgtgaagaaagtgaaacagtccctggcccagtcccacctgcctgcccagcccgacatctcacccaacatttttgaagctgtcaagggctgccacttgtttggggcaggcaagattgagaacgggctctgcatctgtgcagccatgcccagcaaagtcgtcattctccgctacaacgaaaacctcagcaaatactgcatccggaaagagatagagacctcagagccctgcagctgtatccacttcaccaattacagtatcctcattggaaccaataaattctacgaaatcgacatgaagcagtacacgctcgaggaattcctggataagaatgaccattccttggcacctgctgtgtttgccgcctcttccaacagcttccctgtctcaatcgtgcaggtgaacagcgcagggcagcgagaggagtacttgctgtgtttccacgaatttggagtgttcgtggattcttacggaagacgtagccgcacagacgatctcaagtggagtcgcttacctttggcctttgcctacagagaaccctatctgtttgtgacccacttcaactcactcgaagtaattgagatccaggcacgctcctcagcagggacccctgcccgagcgtacctggacatcccgaacccgcgctacctgggccctgccatttcctcaggagcgatttacttggcgtcctcataccaggataaattaagggtcatttgctgcaagggaaacctcgtgaaggagtccggcactgaacaccaccggggcccgtccacctcccgcagcagccccaacaagcgaggcccacccacgtacaacgagcacatcaccaagcgcgtggcctccagcccagcgccgcccgaaggccccagccacccgcgagagccaagcacaccccaccgctaccgcgaggggcggaccgagctgcgcagggacaagtctcctggccgccccctggagcgagagaagtcccccggccggatgctcagcacgcggagagagcggtcccccgggaggctgtttgaagacagcagcaggggccggctgcctgcgggagccgtgaggaccccgctgtcccaggtgaacaaggtctgggaccagtcttcagtataaatctcagccagaaaaaccaactcctcatcttgatctgcaggaaaacaccaaacacactatggaactctgctgatggggacccaagcgcccacgtgctcagccaccctctggctcagcggggcccagacccacctcggcacggacacccctgtctccaggaggggcaggtggctgaggctcttcggagctgtcagcgcccggtgcctgccctgggcacctccctgcagtcatctctttgcactttgttactctttcaaagcattcacaaacttttgtacctagctctagcctgtaccagttagttcatcaaaggaaaccaaccgggatgctaactacaacatggttagaatcctaattagctactttaagatcctaggattggttggtttttcttttttttttctctttgtttctttcctttttttttttttttttttaagacaacagaattcttaatagatttgaatagcgacgtatttcctgttgtagtcatttttagctcgaccacatcatcaggtctttgccaccgaggcatagtgtagaacagtcccggtcagttggccaacctcccgcagccaagtaggttcatccttgttcctgttcattctcatagatggccctgctttccccagggtgacatcgtagccaaatgtttactgttttcattgccttttatggccttgacgacttcccctcccaccagctgagaatgtatggaggtcatcggggcctcagctcggaggcagtgacttggggccaagggacctcgagacgctttccttccccaccccccagcgtcatctccccagcctgctgttcccgctttccatatagctttggccaggaaagcatgcaatagacttgctcggagcccagcactcctgggtctcggggtcggggaggggacgggggcacccacttccttgtctgtgacggcgtgttgttccccactctgggatggggaagaggcccgtcgggagttctgcatggcagttcactgcatgtgctgcccccttgggttgctctgccaatgtattaataccatcccatagctcctgccaaatcgagaccctctgacgacttgccgactaactggccaccacaagctgcagtctgtagcactgaacaaacaaaaaacaaaacgctcaagccttacgaccagagaaggatttcagcaaaccaccacctcccactcagtgtcccctccaaacttcacacttccctgcctgcagaggatgactctgttcacacccaatccagcgcggttctaccccacgaaactgtgactttccaaatgagcctttccctagggctagacctaagaccaggaagtttgagaaagcagccgcagctcaactcttccagctccgccagggttgggaagtccttaggtgcagtgcggctcccactgggtctgcggaccctcctattagagtacgaaattcctggcaactggtacagaaccaacctagaggctttgcagttggcaagctaactcgcggccttatttctgcctttaatctcccacaaggcatctgttgctttgggtcctccacgactcttaggcccgcctcaacaacccaggcacctcctaggtaggctcaaaggtagacccgtttccaccgcagcaggtgaacatgaccgtgttttcaactgtgtccacagttcagatccctttccagattgcaacctggcctgcatcccagctccttcctgctcgtgtcttaacctaagtgctttcttgtttgaaacgcctacaaacctccatgtggtagctcctttggcaaatgtcctgctgtggcgttttatgtgttgcttggagtctgtggggtcgtactccctcccctcccgtccccagggcagatttgattgaatgtttgctgaagttttgtctcttggtccacagtatttggaaaggtcactgaaaatgggtctttcagtcttggcatttcatttaggatctccatgagaaatgggcttcttgagccctgaaaatgtatattgtgtgtctcatctgtgaactgctttctgctatatagaactagctcaaaagactgtacatatttacaagaaactttatattcgtaaaaaaaaaaagaggaaattgaattggtttctacttttttattgtaaaaggtgcatttttcaacacttacttttggtttcaatggtggtagttgtggacagccatcttcactggagggtggggagctccgtgtgaccaccaagatgccagcaggatataccgtaacacgaaattgctgtcaaaagcttattagcatcaatcaagattctaggtctccaaaagtacaggctttttcttcattaccttttttattcagaacgaggaagagaacacaaggaatgattcaagatccaccttgagaggaatgaactttgttgttgaacaattagtgaaataaagcaatgatctaaactaat
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:11113 -> Molecular function: GO:0004674 [protein serine/threonine kinase activity] evidence: ISS
GeneID:11113 -> Molecular function: GO:0005083 [small GTPase regulator activity] evidence: IEA
GeneID:11113 -> Molecular function: GO:0005524 [ATP binding] evidence: IEA
GeneID:11113 -> Molecular function: GO:0005543 [phospholipid binding] evidence: IEA
GeneID:11113 -> Molecular function: GO:0017124 [SH3 domain binding] evidence: IEA
GeneID:11113 -> Molecular function: GO:0046872 [metal ion binding] evidence: IEA
GeneID:11113 -> Biological process: GO:0000070 [mitotic sister chromatid segregation] evidence: IEA
GeneID:11113 -> Biological process: GO:0000910 [cytokinesis] evidence: IMP
GeneID:11113 -> Biological process: GO:0007067 [mitosis] evidence: ISS
GeneID:11113 -> Biological process: GO:0007091 [metaphase/anaphase transition of mitotic cell cycle] evidence: IEA
GeneID:11113 -> Biological process: GO:0007283 [spermatogenesis] evidence: IEA
GeneID:11113 -> Biological process: GO:0016358 [dendrite development] evidence: IEA
GeneID:11113 -> Biological process: GO:0035556 [intracellular signal transduction] evidence: IEA
GeneID:11113 -> Biological process: GO:0048699 [generation of neurons] evidence: ISS
GeneID:11113 -> Biological process: GO:0050774 [negative regulation of dendrite morphogenesis] evidence: IEA
GeneID:11113 -> Cellular component: GO:0001726 [ruffle] evidence: IEA
GeneID:11113 -> Cellular component: GO:0005773 [vacuole] evidence: IEA
GeneID:11113 -> Cellular component: GO:0015629 [actin cytoskeleton] evidence: IEA
ANNOTATIONS from NCBI Entrez Gene (20130726):
NP_009105 -> EC 2.7.11.1
by
@meso_cacase at
DBCLS
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