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2024-04-19 18:57:25, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_006989 5606 bp mRNA linear PRI 17-APR-2013
DEFINITION Homo sapiens RAS p21 protein activator 4 (RASA4), transcript
variant 1, mRNA.
ACCESSION NM_006989 XM_936264
VERSION NM_006989.5 GI:299829176
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 5606)
AUTHORS Dai,Y., Walker,S.A., de Vet,E., Cook,S., Welch,H.C. and
Lockyer,P.J.
TITLE Ca2+-dependent monomer and dimer formation switches CAPRI Protein
between Ras GTPase-activating protein (GAP) and RapGAP activities
JOURNAL J. Biol. Chem. 286 (22), 19905-19916 (2011)
PUBMED 21460216
REMARK GeneRIF: Ca2+-dependent monomer and dimer formation switches CAPRI
Protein between Ras GTPase-activating protein (GAP) and RapGAP
activities
REFERENCE 2 (bases 1 to 5606)
AUTHORS Liu,Q., Walker,S.A., Gao,D., Taylor,J.A., Dai,Y.F., Arkell,R.S.,
Bootman,M.D., Roderick,H.L., Cullen,P.J. and Lockyer,P.J.
TITLE CAPRI and RASAL impose different modes of information processing on
Ras due to contrasting temporal filtering of Ca2+
JOURNAL J. Cell Biol. 170 (2), 183-190 (2005)
PUBMED 16009725
REMARK GeneRIF: CAPRI seems to low-pass filter the Ca2+ signal, converting
different intensities of stimulation into different durations of
Ras activity.
REFERENCE 3 (bases 1 to 5606)
AUTHORS Minagawa,T., Fukuda,M. and Mikoshiba,K.
TITLE Distinct phosphoinositide binding specificity of the GAP1 family
proteins: characterization of the pleckstrin homology domains of
MRASAL and KIAA0538
JOURNAL Biochem. Biophys. Res. Commun. 288 (1), 87-90 (2001)
PUBMED 11594756
REFERENCE 4 (bases 1 to 5606)
AUTHORS Lockyer,P.J., Kupzig,S. and Cullen,P.J.
TITLE CAPRI regulates Ca(2+)-dependent inactivation of the Ras-MAPK
pathway
JOURNAL Curr. Biol. 11 (12), 981-986 (2001)
PUBMED 11448776
REMARK GeneRIF: CAPRI (Ca2+-promoted Ras inactivator) a Ca2+-dependent Ras
GTPase-activating protein (Ras GAP). Switches off the Ras-MAPK
pathway following G protein-coupled receptor stimulated
intracellular Ca2+ elevation that recruits CAPRI to the plasma
membrane.
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from AC105052.3 and AC093668.4.
On Jun 30, 2010 this sequence version replaced gi:121114293.
Summary: This gene encodes a member of the GAP1 family of
GTPase-activating proteins that suppresses the
Ras/mitogen-activated protein kinase pathway in response to Ca(2+).
Stimuli that increase intracellular Ca(2+) levels result in the
translocation of this protein to the plasma membrane, where it
activates Ras GTPase activity. Consequently, Ras is converted from
the active GTP-bound state to the inactive GDP-bound state and no
longer activates downstream pathways that regulate gene expression,
cell growth, and differentiation. Multiple transcript variants
encoding different isoforms have been found for this gene.
[provided by RefSeq, Jul 2008].
Transcript Variant: This variant (1) represents the longer
transcript and encodes the longer isoform (1).
Sequence Note: The RefSeq transcript and protein were derived from
genomic sequence to make the sequence consistent with the reference
genome assembly. The genomic coordinates used for the transcript
record were based on alignments.
##Evidence-Data-START##
Transcript exon combination :: AB011110.2, BC110873.1 [ECO:0000332]
RNAseq introns :: mixed/partial sample support
ERS025081, ERS025082 [ECO:0000350]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-134 AC105052.3 30366-30499 c
135-191 AC105052.3 24827-24883 c
192-305 AC105052.3 23082-23195 c
306-367 AC105052.3 22502-22563 c
368-497 AC105052.3 19599-19728 c
498-579 AC105052.3 16065-16146 c
580-711 AC105052.3 13998-14129 c
712-806 AC105052.3 13601-13695 c
807-924 AC105052.3 9753-9870 c
925-1075 AC105052.3 9375-9525 c
1076-1140 AC105052.3 9046-9110 c
1141-1253 AC105052.3 8188-8300 c
1254-1446 AC105052.3 7791-7983 c
1447-1584 AC105052.3 7448-7585 c
1585-1729 AC105052.3 6735-6879 c
1730-1899 AC105052.3 6026-6195 c
1900-2037 AC105052.3 3900-4037 c
2038-2173 AC105052.3 1376-1511 c
2174-2294 AC093668.4 198168-198288 c
2295-2359 AC093668.4 196954-197018 c
2360-5606 AC093668.4 193596-196842 c
FEATURES Location/Qualifiers
source 1..5606
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="7"
/map="7q22"
gene 1..5606
/gene="RASA4"
/gene_synonym="CAPRI; GAPL"
/note="RAS p21 protein activator 4"
/db_xref="GeneID:10156"
/db_xref="HGNC:23181"
/db_xref="MIM:607943"
exon 1..134
/gene="RASA4"
/gene_synonym="CAPRI; GAPL"
/inference="alignment:Splign:1.39.8"
variation complement(29)
/gene="RASA4"
/gene_synonym="CAPRI; GAPL"
/replace="c"
/replace="g"
/db_xref="dbSNP:376878121"
variation complement(35)
/gene="RASA4"
/gene_synonym="CAPRI; GAPL"
/replace="c"
/replace="g"
/db_xref="dbSNP:374409068"
CDS 70..2481
/gene="RASA4"
/gene_synonym="CAPRI; GAPL"
/note="isoform 1 is encoded by transcript variant 1; Ras
GTPase-activating protein 4; Ca2+-promoted Ras
inactivator; calcium-promoted Ras inactivator;
rasGAP-activating-like protein 2"
/codon_start=1
/product="ras GTPase-activating protein 4 isoform 1"
/protein_id="NP_008920.5"
/db_xref="GI:299829177"
/db_xref="CCDS:CCDS5725.1"
/db_xref="GeneID:10156"
/db_xref="HGNC:23181"
/db_xref="MIM:607943"
/translation="
MAKRSSLYIRIVEGKNLPAKDITGSSDPYCIVKVDNEPIIRTATVWKTLCPFWGEEYQVHLPPTFHAVAFYVMDEDALSRDDVIGKVCLTRDTIASHPKGFSGWAHLTEVDPDEEVQGEIHLRLEVWPGARACRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTRETSIVKKSCYPRWNETFEFELQEGAMEALCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRLQPDQSKSRRHDEGNLGSLQLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGPGQLIPLIEETTSTECRQDVATNLLKLFLGQGLAKDFLDLLFQLELSRTSETNTLFRSNSLASKSMESFLKVAGMQYLHGVLGPIINKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHLGALLSALSRSVRACPAVVRATFRQLFRRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIMSPKLFHLRERHADARTSRTLLLLAKAVQNVGNMDTPASRAKEAWMEPLQPTVRQGVAQLKDFITKLVDIEEKDELDLQRTLSLQAPPVKEGPLFIHRTKGKGPLMSSSFKKLYFSLTTEALSFAKTPSSKKSALIKLANIRAAEKVEEKSFGGSHVMQVIYTDDAGRPQTAYLQCKCVNELNQWLSALRKVSINNTGLLGSYHPGVFRGDKWSCCHQKEKTGQGCDKTRSRVTLQEWNDPLDHDLEAQLIYRHLLGVEAMLWERHRELSGGAEAGTVPTSPGKVPEDSLARLLRVLQDLREAHSSSPAGSPPSEPNCLLELQT
"
misc_feature 85..447
/gene="RASA4"
/gene_synonym="CAPRI; GAPL"
/note="C2 domain first repeat present in RasA1 and RasA4;
Region: C2A_Rasal1_RasA4; cd04054"
/db_xref="CDD:176018"
misc_feature order(130..132,148..150,289..291,295..297,313..315)
/gene="RASA4"
/gene_synonym="CAPRI; GAPL"
/note="Ca2+ binding pocket [ion binding]; other site"
/db_xref="CDD:176018"
misc_feature 469..840
/gene="RASA4"
/gene_synonym="CAPRI; GAPL"
/note="C2 domain second repeat present in RasA1 and RasA4;
Region: C2B_RasA1_RasA4; cd04025"
/db_xref="CDD:175991"
misc_feature order(514..516,532..534,673..675,679..681,697..699)
/gene="RASA4"
/gene_synonym="CAPRI; GAPL"
/note="Ca2+ binding pocket [ion binding]; other site"
/db_xref="CDD:175991"
misc_feature 868..1860
/gene="RASA4"
/gene_synonym="CAPRI; GAPL"
/note="Ras GTPase activating-like 4 protein (RASAL4), also
known as Ca2+ -promoted Ras inactivator (CAPRI), is a
member of the GAP1 family. Members of the GAP1 family are
characterized by a conserved domain structure comprising
N-terminal tandem C2 domains, a...; Region: RasGAP_RASA4;
cd05395"
/db_xref="CDD:88581"
misc_feature order(976..978,1084..1086,1096..1107,1126..1128,
1459..1461,1483..1488,1495..1500,1582..1584,1603..1605,
1609..1611,1630..1635)
/gene="RASA4"
/gene_synonym="CAPRI; GAPL"
/note="putative GAP/RAS interaction site [polypeptide
binding]; other site"
/db_xref="CDD:88581"
misc_feature 1774..2082
/gene="RASA4"
/gene_synonym="CAPRI; GAPL"
/note="RAS_GTPase activating protein (GAP)_CG9209
pleckstrin homology (PH) domain; Region: PH_RasGAP_CG9209;
cd01244"
/db_xref="CDD:176320"
misc_feature order(1792..1794,1798..1800,1837..1839,1843..1851)
/gene="RASA4"
/gene_synonym="CAPRI; GAPL"
/note="putative phosphoinositide binding site [chemical
binding]; other site"
/db_xref="CDD:176320"
misc_feature 2110..2199
/gene="RASA4"
/gene_synonym="CAPRI; GAPL"
/note="BTK motif; Region: BTK; pfam00779"
/db_xref="CDD:144394"
variation complement(82)
/gene="RASA4"
/gene_synonym="CAPRI; GAPL"
/replace="a"
/replace="t"
/db_xref="dbSNP:146516658"
variation complement(90)
/gene="RASA4"
/gene_synonym="CAPRI; GAPL"
/replace="a"
/replace="g"
/db_xref="dbSNP:150204185"
exon 135..191
/gene="RASA4"
/gene_synonym="CAPRI; GAPL"
/inference="alignment:Splign:1.39.8"
exon 192..305
/gene="RASA4"
/gene_synonym="CAPRI; GAPL"
/inference="alignment:Splign:1.39.8"
exon 306..367
/gene="RASA4"
/gene_synonym="CAPRI; GAPL"
/inference="alignment:Splign:1.39.8"
exon 368..497
/gene="RASA4"
/gene_synonym="CAPRI; GAPL"
/inference="alignment:Splign:1.39.8"
variation complement(375)
/gene="RASA4"
/gene_synonym="CAPRI; GAPL"
/replace="a"
/replace="c"
/db_xref="dbSNP:140941587"
variation complement(392)
/gene="RASA4"
/gene_synonym="CAPRI; GAPL"
/replace="c"
/replace="t"
/db_xref="dbSNP:151024405"
variation complement(400)
/gene="RASA4"
/gene_synonym="CAPRI; GAPL"
/replace="a"
/replace="g"
/db_xref="dbSNP:372956201"
variation complement(408)
/gene="RASA4"
/gene_synonym="CAPRI; GAPL"
/replace="a"
/replace="c"
/replace="t"
/db_xref="dbSNP:142342278"
variation complement(417)
/gene="RASA4"
/gene_synonym="CAPRI; GAPL"
/replace="g"
/replace="t"
/db_xref="dbSNP:369222056"
variation complement(436)
/gene="RASA4"
/gene_synonym="CAPRI; GAPL"
/replace="c"
/replace="t"
/db_xref="dbSNP:139960113"
variation complement(491)
/gene="RASA4"
/gene_synonym="CAPRI; GAPL"
/replace="a"
/replace="g"
/db_xref="dbSNP:200132914"
exon 498..579
/gene="RASA4"
/gene_synonym="CAPRI; GAPL"
/inference="alignment:Splign:1.39.8"
exon 580..711
/gene="RASA4"
/gene_synonym="CAPRI; GAPL"
/inference="alignment:Splign:1.39.8"
variation complement(697)
/gene="RASA4"
/gene_synonym="CAPRI; GAPL"
/replace="a"
/replace="g"
/db_xref="dbSNP:148994026"
exon 712..806
/gene="RASA4"
/gene_synonym="CAPRI; GAPL"
/inference="alignment:Splign:1.39.8"
exon 807..924
/gene="RASA4"
/gene_synonym="CAPRI; GAPL"
/inference="alignment:Splign:1.39.8"
exon 925..1075
/gene="RASA4"
/gene_synonym="CAPRI; GAPL"
/inference="alignment:Splign:1.39.8"
exon 1076..1140
/gene="RASA4"
/gene_synonym="CAPRI; GAPL"
/inference="alignment:Splign:1.39.8"
variation complement(1096)
/gene="RASA4"
/gene_synonym="CAPRI; GAPL"
/replace="c"
/replace="t"
/db_xref="dbSNP:144817729"
variation complement(1115)
/gene="RASA4"
/gene_synonym="CAPRI; GAPL"
/replace="a"
/replace="c"
/db_xref="dbSNP:141060382"
variation complement(1123)
/gene="RASA4"
/gene_synonym="CAPRI; GAPL"
/replace="a"
/replace="g"
/db_xref="dbSNP:144395384"
variation complement(1125)
/gene="RASA4"
/gene_synonym="CAPRI; GAPL"
/replace="g"
/replace="t"
/db_xref="dbSNP:370139033"
exon 1141..1253
/gene="RASA4"
/gene_synonym="CAPRI; GAPL"
/inference="alignment:Splign:1.39.8"
variation complement(1172)
/gene="RASA4"
/gene_synonym="CAPRI; GAPL"
/replace="c"
/replace="t"
/db_xref="dbSNP:372070045"
exon 1254..1446
/gene="RASA4"
/gene_synonym="CAPRI; GAPL"
/inference="alignment:Splign:1.39.8"
exon 1447..1584
/gene="RASA4"
/gene_synonym="CAPRI; GAPL"
/inference="alignment:Splign:1.39.8"
exon 1585..1729
/gene="RASA4"
/gene_synonym="CAPRI; GAPL"
/inference="alignment:Splign:1.39.8"
exon 1730..1899
/gene="RASA4"
/gene_synonym="CAPRI; GAPL"
/inference="alignment:Splign:1.39.8"
exon 1900..2037
/gene="RASA4"
/gene_synonym="CAPRI; GAPL"
/inference="alignment:Splign:1.39.8"
exon 2038..2173
/gene="RASA4"
/gene_synonym="CAPRI; GAPL"
/inference="alignment:Splign:1.39.8"
exon 2174..2294
/gene="RASA4"
/gene_synonym="CAPRI; GAPL"
/inference="alignment:Splign:1.39.8"
variation complement(2261)
/gene="RASA4"
/gene_synonym="CAPRI; GAPL"
/replace="a"
/replace="g"
/db_xref="dbSNP:201206752"
exon 2295..2359
/gene="RASA4"
/gene_synonym="CAPRI; GAPL"
/inference="alignment:Splign:1.39.8"
exon 2360..5606
/gene="RASA4"
/gene_synonym="CAPRI; GAPL"
/inference="alignment:Splign:1.39.8"
polyA_site 2934
/gene="RASA4"
/gene_synonym="CAPRI; GAPL"
variation complement(3907)
/gene="RASA4"
/gene_synonym="CAPRI; GAPL"
/replace="c"
/replace="t"
/db_xref="dbSNP:143668034"
variation complement(4113)
/gene="RASA4"
/gene_synonym="CAPRI; GAPL"
/replace="a"
/replace="g"
/db_xref="dbSNP:368246765"
variation complement(4162)
/gene="RASA4"
/gene_synonym="CAPRI; GAPL"
/replace="a"
/replace="g"
/db_xref="dbSNP:376488381"
STS 4201..4267
/gene="RASA4"
/gene_synonym="CAPRI; GAPL"
/standard_name="GDB:4585406"
/db_xref="UniSTS:40002"
variation complement(4293)
/gene="RASA4"
/gene_synonym="CAPRI; GAPL"
/replace="a"
/replace="g"
/db_xref="dbSNP:148998561"
variation complement(4394)
/gene="RASA4"
/gene_synonym="CAPRI; GAPL"
/replace="g"
/replace="t"
/db_xref="dbSNP:200553107"
variation complement(4406..4409)
/gene="RASA4"
/gene_synonym="CAPRI; GAPL"
/replace=""
/replace="tttt"
/db_xref="dbSNP:143912199"
STS 4455..4565
/gene="RASA4"
/gene_synonym="CAPRI; GAPL"
/standard_name="D10S275"
/db_xref="UniSTS:147992"
STS 4465..4534
/gene="RASA4"
/gene_synonym="CAPRI; GAPL"
/standard_name="D1S1423"
/db_xref="UniSTS:149619"
STS 4496..4584
/gene="RASA4"
/gene_synonym="CAPRI; GAPL"
/standard_name="D8S2279"
/db_xref="UniSTS:473907"
variation complement(4613)
/gene="RASA4"
/gene_synonym="CAPRI; GAPL"
/replace="a"
/replace="g"
/db_xref="dbSNP:145870823"
STS 4769..4925
/gene="RASA4"
/gene_synonym="CAPRI; GAPL"
/standard_name="RH47924"
/db_xref="UniSTS:86874"
variation complement(4862)
/gene="RASA4"
/gene_synonym="CAPRI; GAPL"
/replace="a"
/replace="g"
/db_xref="dbSNP:368684154"
variation complement(4863..4864)
/gene="RASA4"
/gene_synonym="CAPRI; GAPL"
/replace=""
/replace="g"
/db_xref="dbSNP:147078079"
variation complement(4869)
/gene="RASA4"
/gene_synonym="CAPRI; GAPL"
/replace="a"
/replace="t"
/db_xref="dbSNP:371475242"
variation complement(4880)
/gene="RASA4"
/gene_synonym="CAPRI; GAPL"
/replace="g"
/replace="t"
/db_xref="dbSNP:373687264"
STS 5328..5501
/gene="RASA4"
/gene_synonym="CAPRI; GAPL"
/standard_name="STS-AA025752"
/db_xref="UniSTS:65020"
STS 5336..5423
/gene="RASA4"
/gene_synonym="CAPRI; GAPL"
/standard_name="GDB:4585437"
/db_xref="UniSTS:65729"
variation complement(5412)
/gene="RASA4"
/gene_synonym="CAPRI; GAPL"
/replace="g"
/replace="t"
/db_xref="dbSNP:199610101"
polyA_signal 5584..5589
/gene="RASA4"
/gene_synonym="CAPRI; GAPL"
polyA_site 5606
/gene="RASA4"
/gene_synonym="CAPRI; GAPL"
ORIGIN
ccagtccagcgcccgccgcccgccaccccggaccccggtgtctggcttcccccgagccgggaccccgcgatggccaagcgcagctcgctgtacatccgcatcgtggaggggaagaaccttcccgccaaggacatcactggcagcagcgacccctactgcatcgtgaaggtggacaatgagcccatcatcaggacagccacagtgtggaagaccctgtgccccttctggggtgaggagtaccaagtgcacctgccgcccaccttccacgctgtggctttctatgtcatggatgaggatgccctcagccgggacgacgttatcggaaaggtctgccttacaagggacaccatagcctctcaccctaagggtttcagcgggtgggcccacctgacggaggtcgaccccgatgaggaggtgcagggcgagatccacctgcggctggaagtgtggccaggggcccgggcctgccggctacgctgctctgtgctggaggccagggatctggccccaaaggaccgcaatggcacatctgaccccttcgtccgagtgcgctacaagggccggacacgggagacctcgatcgtgaagaagtcatgctacccacgctggaatgagacgtttgaatttgagctgcaggagggggccatggaggcgctgtgcgtggaggcctgggactgggaccttgtcagccgaaacgacttcctgggcaaagtggtgattgatgtccagagactgcgggtggtgcagcaggaggagggctggttccggctgcagcccgaccagtccaagagccggcggcatgacgagggcaacctgggctccttgcagctggaggtgcggctgcgggacgagacggtgctgccctccagctactaccagccactggtgcacctgctgtgccacgaggtcaagctgggcatgcagggcccagggcagctgatcccactcatcgaggagacaaccagcaccgagtgtcgccaggacgtggccacgaacctgctcaagctcttcctggggcaggggctggccaaggacttcctggacctgctcttccagctggagctgagtcgcaccagtgagaccaacaccctgttccggagcaactctctggcctcaaagtccatggagtcttttctgaaggtggccgggatgcagtacctgcacggcgtcctgggccccatcatcaacaaggtgtttgaggagaagaagtacgtggagctggaccccagcaaagtggaagttaaggatgtagggtgctccgggctgcaccgcccgcagaccgaggccgaggtgctggagcagagcgcgcagacgctgcgcgcccacctgggggccctgctgagcgcgctcagccgctcggttcgcgcgtgccccgccgtggtgcgcgccaccttccgccagctcttccggcgcgtgcgcgagcgcttccccggcgcccagcacgagaatgtaccgttcatcgccgtcaccagcttcctgtgcctgcgcttcttctctcccgccatcatgtcgcccaagctcttccacctgcgggagcgccacgcggacgcccgcaccagccgcaccctgctcctgttggccaaggcagtccagaacgtgggcaacatggacacgccggcttccagggccaaggaggcttggatggagccgctgcagcccaccgtgcgccagggcgtggcgcagctgaaggacttcatcaccaagctcgtggacatcgaggagaaggacgagctggacctgcagcggacgctgagtttgcaggcgccacctgtgaaggaggggccactcttcatccacaggaccaagggcaagggccccctcatgtcctcctccttcaagaagctctacttctccctcactaccgaggccctcagcttcgcgaagacgcccagctccaagaaaagcgccctcatcaagttagccaacatccgggcagcggaaaaggttgaggaaaagagctttggcggctcgcacgtcatgcaggtcatctacacggacgacgccggcaggccccagactgcctacctgcagtgcaagtgtgtgaatgagcttaaccagtggctgtctgcgctgcggaaggtgagcatcaacaacaccggactgctgggctcctaccaccctggcgtcttccgtggggacaagtggagctgctgccaccaaaaagagaagacaggtcagggctgcgataagacccggtcacgggtgaccctgcaggagtggaatgaccctcttgaccatgaccttgaggcccagctcatctaccggcacctgctgggcgtggaggccatgctgtgggagaggcaccgggagctgagcgggggcgcagaggcaggcacggtgcccacgagccctggcaaagtccccgaggactcattggcccggctgctccgggtgctgcaggacctccgcgaggcccatagctccagcccggccggctccccaccctcagagcccaactgcctcctggagctgcagacgtgaggcccgccctacgctccccttgctgagtcccctgccaagcgctcggagcccccccaggacactctgcaccccctcaccccggtcctcctcattagggtgcagggcctaggtctcttccaggtgggggaggggggagagtcaggaataaggggatccccagaagtgcagagctgagcaggcttgggcctgtcatggctggccggaagtgtccccagctccctacagacgctgtagccatcactgcctctccagggaccctcctctcctgcccaggacagacccagccagaaccactgctaggatgggccgcacccaggggtctggcctccagggacctagagaatgggagggagaacggggccccaggagacccggccgccaccccacccgctacccttgggtgccacagggctgtgctgttgccaacagtaaacctgctcttactgtccaggctctggggtcttgtgatgagggtctggggagaaagtgggcccggggggaccccggaggctgtcggtggatgtgccgatgatggggctgacagtatgggctctgggcatccctgttcccccctctttcttccccccactcttctggggtcgggggttcctttcccttcccagttgctgtccctgggtcccctctttcatgtcccacaggccacagagcccagtgtgtccaaccagctgttctctcctcaaagcagcccccaagcaagtcccttctctagggtgtccctgaggacagcacagaggcgggactcagagaccccattcctcttcacgcagcccttaccccaagccctctagctgtgtggctggcagtgttggccacgtaggggctcccatccccccaccattgtgtcacatgggctgccaggctcagctcccagctgcgtccacagtgacctggatcagggtggggacaaggactggaccctccttctccagaaggccttcagctcttgccttgccatgcagtcacctccttccccctctgaccccagatcccaaaggtgcaccgttgccccagcccctttctggccccatggggtttctctgatgccttcatcatagaggcccggggctggtccgatggttggcaaaacttgactccggcccagtccccactcttggggacttagaacccctgctgtcctgggatctggcctgcctttctttggtcagtccctgtggtcccccaccagctccccctcccatagggctgcccaccaagccctgcccccagcccaagaggagcccccactgcctgcggggcagtgatgtctggccaccggctcacaccaatgacttggtcctggggtggcagaagcagcaggtgacaggagcagggcccctgtccctctcttctggccctgtggtacccaggccacacgttgtgcccgctcttggggctgaccggctgtagggaccaccagccgctgctactgtgggccgccccggggcagggtgggcagggcttttgtgggttatgaggacacagaagtccctgaggcccccagacctggctcagccaacctccttcctcccccggttgccccccactctaaagcctcctccctcccagcgtccactggctccaggctcctcacaacagcagctcatagacacggggcgtctccaggtggtcccagccctccagatgtttctagctctccaggtgggcgctgttttcacgtctgcctgcatccattcattccttcattcctcacctttatcctgttatctctatttttttaagctaccaggaaggaaagggaagaagagatcacgaaactgggacccccagaaaggaggagtgggctttgaacttagacatctacctcagagctcaaataggttgtttaaaatcacattcaattttcagatgaaggggaactttatagttttttttttttttttttttttgagacagagtctcactgtgttgcccaggctggagtgcaaatggcttgatcttggttcactgcaacctctgcctcccaggttcaagcaattctcttgcctcagcctcccgagtagctgggactaaaggcgtgtgccaccatgcccagctaattcttgtatttttagtagagacggagtttctccatgttggccagactggtctcgaactcctgacctcaggtgatctgaccgccttggcctccgaaagtgctgagattacagttgcgagccactgtgcgtggccagaactttataataagagacttgaagctgggtgtgacggtgcacacctctagtcccagctactcgggaggccaagacagaaggatcaccttgaggccaggagtttaaggccagcctgggcaacatagcaaaacctagtccctaaaattaaaaaaaaaaaaaaaaaaaaaaggaaaataaaggagacttgaaatttttgaactaaatagtggtgatggctacacattgtgaatgtaattaacaccactgagttaaacacttaaaatggttaaaatggcaaattgtatgttatacctattttactacaataaaaagtataaaaaagagaagatatttaggtgacttacagcaaccaattgcaacaaaacaaaatgttaagaaatgatctttttatgaggcaattggaaatttgaacactgatcaactataggatgattggaattattaatttttaaaggtgtgataagatactgcacttggctgggcacagtggcacatgcctgtaatcccagctacttggcaggctgaggtgggagaatcgcttgagctcaggagttcgagaccagcctgggcaacgtggcgaaatccccgtctttacaaaaacaaacaaacaaacaaaaaagatattgcagttgtgttgtaagcgtccttatctttcagagctacatagtggaatgtttatggaatatttaggataaatgatataggcatttgggatttgctgcaaaatgacccagaggcaggggtcagggggagaggtagagatgagacaagaggtagaggggagaggtagaggtagccacgagctgataattacagacaagagatgcggagtatgtgggggctcattatcctgcatagtctatctttgtatatctttgaacttttcaagaataaaaaagcttaaaaagtata
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:10156 -> Molecular function: GO:0005096 [GTPase activator activity] evidence: IDA
GeneID:10156 -> Molecular function: GO:0005099 [Ras GTPase activator activity] evidence: ISS
GeneID:10156 -> Molecular function: GO:0005543 [phospholipid binding] evidence: IEA
GeneID:10156 -> Molecular function: GO:0046872 [metal ion binding] evidence: IEA
GeneID:10156 -> Biological process: GO:0032320 [positive regulation of Ras GTPase activity] evidence: ISS
GeneID:10156 -> Biological process: GO:0035556 [intracellular signal transduction] evidence: IEA
GeneID:10156 -> Biological process: GO:0046580 [negative regulation of Ras protein signal transduction] evidence: ISS
GeneID:10156 -> Cellular component: GO:0005737 [cytoplasm] evidence: ISS
GeneID:10156 -> Cellular component: GO:0005829 [cytosol] evidence: IEA
GeneID:10156 -> Cellular component: GO:0031235 [intrinsic to internal side of plasma membrane] evidence: ISS
by
@meso_cacase at
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