LOCUS       NM_006219               5931 bp    mRNA    linear   PRI 16-JUN-2013
DEFINITION  Homo sapiens phosphatidylinositol-4,5-bisphosphate 3-kinase,
            catalytic subunit beta (PIK3CB), transcript variant 1, mRNA.
ACCESSION   NM_006219
VERSION     NM_006219.2  GI:365777409
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5931)
  AUTHORS   Dou,Z., Pan,J.A., Dbouk,H.A., Ballou,L.M., DeLeon,J.L., Fan,Y.,
            Chen,J.S., Liang,Z., Li,G., Backer,J.M., Lin,R.Z. and Zong,W.X.
  TITLE     Class IA PI3K p110beta subunit promotes autophagy through Rab5
            small GTPase in response to growth factor limitation
  JOURNAL   Mol. Cell 50 (1), 29-42 (2013)
   PUBMED   23434372
  REMARK    GeneRIF: In mammalian cells, p110beta acts as a molecular sensor
            for growth factor availability and induces autophagy by activating
            a Rab5-mediated signaling cascade.
REFERENCE   2  (bases 1 to 5931)
  AUTHORS   Dbouk,H.A., Vadas,O., Shymanets,A., Burke,J.E., Salamon,R.S.,
            Khalil,B.D., Barrett,M.O., Waldo,G.L., Surve,C., Hsueh,C.,
            Perisic,O., Harteneck,C., Shepherd,P.R., Harden,T.K., Smrcka,A.V.,
            Taussig,R., Bresnick,A.R., Nurnberg,B., Williams,R.L. and
            Backer,J.M.
  TITLE     G protein-coupled receptor-mediated activation of p110beta by
            Gbetagamma is required for cellular transformation and invasiveness
  JOURNAL   Sci Signal 5 (253), RA89 (2012)
   PUBMED   23211529
  REMARK    GeneRIF: Disrupting the p110beta-Gbetagamma interaction by mutation
            or with a cell-permeable peptide inhibitor blocked the transforming
            capacity of PI3Kbeta in fibroblasts and reduced the proliferation,
            chemotaxis, and invasiveness
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5931)
  AUTHORS   Silio,V., Redondo-Munoz,J. and Carrera,A.C.
  TITLE     Phosphoinositide 3-kinase beta regulates chromosome segregation in
            mitosis
  JOURNAL   Mol. Biol. Cell 23 (23), 4526-4542 (2012)
   PUBMED   23051731
  REMARK    GeneRIF: p110beta was activated near metaphase and controlled
            dynein/dynactin and Aurora B activities in kinetochores, chromosome
            segregation, and optimal function of the spindle checkpoint
REFERENCE   4  (bases 1 to 5931)
  AUTHORS   Blajecka,K., Marinov,M., Leitner,L., Uth,K., Posern,G. and
            Arcaro,A.
  TITLE     Phosphoinositide 3-kinase C2beta regulates RhoA and the actin
            cytoskeleton through an interaction with Dbl
  JOURNAL   PLoS ONE 7 (9), E44945 (2012)
   PUBMED   22984590
  REMARK    GeneRIF: Phosphoinositide 3-kinase C2beta regulates RhoA and the
            actin cytoskeleton through an interaction with Dbl
REFERENCE   5  (bases 1 to 5931)
  AUTHORS   Krajewski,S., Kurz,J., Geisler,T., Peter,K., Wendel,H.P. and
            Straub,A.
  TITLE     Combined blockade of ADP receptors and PI3-kinase p110beta fully
            prevents platelet and leukocyte activation during hypothermic
            extracorporeal circulation
  JOURNAL   PLoS ONE 7 (6), E38455 (2012)
   PUBMED   22701645
  REMARK    GeneRIF: Combined blockade of P2Y12, P2Y1 and PI3-kinase p110beta
            fully prevents platelet and leukocyte activation during hypothermic
            extracorporeal circulation.
REFERENCE   6  (bases 1 to 5931)
  AUTHORS   Milani,D., Mazzoni,M., Borgatti,P., Zauli,G., Cantley,L. and
            Capitani,S.
  TITLE     Extracellular human immunodeficiency virus type-1 Tat protein
            activates phosphatidylinositol 3-kinase in PC12 neuronal cells
  JOURNAL   J. Biol. Chem. 271 (38), 22961-22964 (1996)
   PUBMED   8798481
REFERENCE   7  (bases 1 to 5931)
  AUTHORS   Bonnefoy-Berard,N., Liu,Y.C., von Willebrand,M., Sung,A., Elly,C.,
            Mustelin,T., Yoshida,H., Ishizaka,K. and Altman,A.
  TITLE     Inhibition of phosphatidylinositol 3-kinase activity by association
            with 14-3-3 proteins in T cells
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 92 (22), 10142-10146 (1995)
   PUBMED   7479742
REFERENCE   8  (bases 1 to 5931)
  AUTHORS   Hu,P. and Schlessinger,J.
  TITLE     Direct association of p110 beta phosphatidylinositol 3-kinase with
            p85 is mediated by an N-terminal fragment of p110 beta
  JOURNAL   Mol. Cell. Biol. 14 (4), 2577-2583 (1994)
   PUBMED   8139559
REFERENCE   9  (bases 1 to 5931)
  AUTHORS   Hu,P., Mondino,A., Skolnik,E.Y. and Schlessinger,J.
  TITLE     Cloning of a novel, ubiquitously expressed human
            phosphatidylinositol 3-kinase and identification of its binding
            site on p85
  JOURNAL   Mol. Cell. Biol. 13 (12), 7677-7688 (1993)
   PUBMED   8246984
REFERENCE   10 (bases 1 to 5931)
  AUTHORS   Carpenter,C.L., Duckworth,B.C., Auger,K.R., Cohen,B.,
            Schaffhausen,B.S. and Cantley,L.C.
  TITLE     Purification and characterization of phosphoinositide 3-kinase from
            rat liver
  JOURNAL   J. Biol. Chem. 265 (32), 19704-19711 (1990)
   PUBMED   2174051
  REMARK    GeneRIF: This paper reports the first purification of a
            phosphoinositide 3-kinase and shows that the protein is a
            heterodimer of an 85 kd regulatory subunit that mediates binding to
            phosphorylated proteins and a 110 kd catalytic subunit.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC117389.5, BC114432.1, AC020890.22 and AI623206.1.
            On Dec 24, 2011 this sequence version replaced gi:5453893.
            
            Summary: This gene encodes an isoform of the catalytic subunit of
            phosphoinositide 3-kinase (PI3K). These kinases are important in
            signaling pathways involving receptors on the outer membrane of
            eukaryotic cells and are named for their catalytic subunit. The
            encoded protein is the catalytic subunit for PI3Kbeta (PI3KB).
            PI3KB has been shown to be part of the activation pathway in
            neutrophils which have bound immune complexes at sites of injury or
            infection. Alternative splicing results in multiple transcript
            variants. [provided by RefSeq, Dec 2011].
            
            Transcript Variant: This variant (1) represent the longer
            transcript and encodes the longer protein (isoform 1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC114432.1, S67334.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           ERS025081, ERS025082 [ECO:0000350]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-16                AC117389.5         36526-36541
            17-3229             BC114432.1         5-3217
            3230-5537           AC020890.22        31397-33704
            5538-5931           AI623206.1         1-394               c
FEATURES             Location/Qualifiers
     source          1..5931
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q22.3"
     gene            1..5931
                     /gene="PIK3CB"
                     /gene_synonym="P110BETA; PI3K; PI3KBETA; PIK3C1"
                     /note="phosphatidylinositol-4,5-bisphosphate 3-kinase,
                     catalytic subunit beta"
                     /db_xref="GeneID:5291"
                     /db_xref="HGNC:8976"
                     /db_xref="HPRD:04234"
                     /db_xref="MIM:602925"
     exon            1..187
                     /gene="PIK3CB"
                     /gene_synonym="P110BETA; PI3K; PI3KBETA; PIK3C1"
                     /inference="alignment:Splign:1.39.8"
     misc_feature    14..16
                     /gene="PIK3CB"
                     /gene_synonym="P110BETA; PI3K; PI3KBETA; PIK3C1"
                     /note="upstream in-frame stop codon"
     CDS             17..3229
                     /gene="PIK3CB"
                     /gene_synonym="P110BETA; PI3K; PI3KBETA; PIK3C1"
                     /EC_number="2.7.1.153"
                     /note="isoform 1 is encoded by transcript variant 1;
                     PI3-kinase p110 subunit beta; PtdIns-3-kinase p110;
                     PI3K-beta; PI3-kinase subunit beta; ptdIns-3-kinase
                     subunit beta; ptdIns-3-kinase subunit p110-beta;
                     phosphatidylinositol-4,5-bisphosphate 3-kinase 110 kDa
                     catalytic subunit beta; phosphatidylinositol
                     4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta;
                     phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic
                     subunit beta isoform; phosphoinositide-3-kinase,
                     catalytic, beta polypeptide"
                     /codon_start=1
                     /product="phosphatidylinositol 4,5-bisphosphate 3-kinase
                     catalytic subunit beta isoform isoform 1"
                     /protein_id="NP_006210.1"
                     /db_xref="GI:5453894"
                     /db_xref="CCDS:CCDS3104.1"
                     /db_xref="GeneID:5291"
                     /db_xref="HGNC:8976"
                     /db_xref="HPRD:04234"
                     /db_xref="MIM:602925"
                     /translation="

MCFSFIMPPAMADILDIWAVDSQIASDGSIPVDFLLPTGIYIQLEVPREATISYIKQMLWKQVHNYPMFNLLMDIDSYMFACVNQTAVYEELEDETRRLCDVRPFLPVLKLVTRSCDPGEKLDSKIGVLIGKGLHEFDSLKDPEVNEFRRKMRKFSEEKILSLVGLSWMDWLKQTYPPEHEPSIPENLEDKLYGGKLIVAVHFENCQDVFSFQVSPNMNPIKVNELAIQKRLTIHGKEDEVSPYDYVLQVSGRVEYVFGDHPLIQFQYIRNCVMNRALPHFILVECCKIKKMYEQEMIAIEAAINRNSSNLPLPLPPKKTRIISHVWENNNPFQIVLVKGNKLNTEETVKVHVRAGLFHGTELLCKTIVSSEVSGKNDHIWNEPLEFDINICDLPRMARLCFAVYAVLDKVKTKKSTKTINPSKYQTIRKAGKVHYPVAWVNTMVFDFKGQLRTGDIILHSWSSFPDELEEMLNPMGTVQTNPYTENATALHVKFPENKKQPYYYPPFDKIIEKAAEIASSDSANVSSRGGKKFLPVLKEILDRDPLSQLCENEMDLIWTLRQDCREIFPQSLPKLLLSIKWNKLEDVAQLQALLQIWPKLPPREALELLDFNYPDQYVREYAVGCLRQMSDEELSQYLLQLVQVLKYEPFLDCALSRFLLERALGNRRIGQFLFWHLRSEVHIPAVSVQFGVILEAYCRGSVGHMKVLSKQVEALNKLKTLNSLIKLNAVKLNRAKGKEAMHTCLKQSAYREALSDLQSPLNPCVILSELYVEKCKYMDSKMKPLWLVYNNKVFGEDSVGVIFKNGDDLRQDMLTLQMLRLMDLLWKEAGLDLRMLPYGCLATGDRSGLIEVVSTSETIADIQLNSSNVAAAAAFNKDALLNWLKEYNSGDDLDRAIEEFTLSCAGYCVASYVLGIGDRHSDNIMVKKTGQLFHIDFGHILGNFKSKFGIKRERVPFILTYDFIHVIQQGKTGNTEKFGRFRQCCEDAYLILRRHGNLFITLFALMLTAGLPELTSVKDIQYLKDSLALGKSEEEALKQFKQKFDEALRESWTTKVNWMAHTVRKDYRS

"
     misc_feature    137..370
                     /gene="PIK3CB"
                     /gene_synonym="P110BETA; PI3K; PI3KBETA; PIK3C1"
                     /note="PI3-kinase family, p85-binding domain; Region:
                     PI3K_p85B; pfam02192"
                     /db_xref="CDD:145379"
     misc_feature    554..880
                     /gene="PIK3CB"
                     /gene_synonym="P110BETA; PI3K; PI3KBETA; PIK3C1"
                     /note="PI3-kinase family, ras-binding domain; Region:
                     PI3K_rbd; pfam00794"
                     /db_xref="CDD:201447"
     misc_feature    986..1519
                     /gene="PIK3CB"
                     /gene_synonym="P110BETA; PI3K; PI3KBETA; PIK3C1"
                     /note="C2 domain present in class I beta and delta
                     phosphatidylinositol 3-kinases (PI3Ks); Region:
                     C2_PI3K_class_I_beta_delta; cd08693"
                     /db_xref="CDD:176075"
     misc_feature    1244..1270
                     /gene="PIK3CB"
                     /gene_synonym="P110BETA; PI3K; PI3KBETA; PIK3C1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P42338.1);
                     Region: Nuclear localization signal"
     misc_feature    1610..2122
                     /gene="PIK3CB"
                     /gene_synonym="P110BETA; PI3K; PI3KBETA; PIK3C1"
                     /note="Phosphoinositide 3-kinase (PI3K) class I, accessory
                     domain ; PIK domain is conserved in all PI3 and
                     PI4-kinases. Its role is unclear but it has been suggested
                     to be involved in substrate presentation. In general, PI3K
                     class I prefer phosphoinositol (4,5)...; Region: PI3Ka_I;
                     cd00872"
                     /db_xref="CDD:29839"
     misc_feature    2132..3217
                     /gene="PIK3CB"
                     /gene_synonym="P110BETA; PI3K; PI3KBETA; PIK3C1"
                     /note="Phosphoinositide 3-kinase (PI3K), class IA, beta
                     isoform, catalytic domain; The PI3K catalytic domain
                     family is part of a larger superfamily that includes the
                     catalytic domains of other kinases such as the typical
                     serine/threonine/tyrosine protein...; Region:
                     PI3Kc_IA_beta; cd05173"
                     /db_xref="CDD:119433"
     misc_feature    order(2351..2353,2357..2365,2369..2371,2423..2425,
                     2429..2431,2438..2440,2531..2533,2567..2578,2591..2593,
                     2600..2602,2786..2788,2792..2794,2822..2827)
                     /gene="PIK3CB"
                     /gene_synonym="P110BETA; PI3K; PI3KBETA; PIK3C1"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:119433"
     misc_feature    2420..3073
                     /gene="PIK3CB"
                     /gene_synonym="P110BETA; PI3K; PI3KBETA; PIK3C1"
                     /note="Phosphoinositide 3-kinase, catalytic domain;
                     Region: PI3Kc; smart00146"
                     /db_xref="CDD:197542"
     misc_feature    2693..2695
                     /gene="PIK3CB"
                     /gene_synonym="P110BETA; PI3K; PI3KBETA; PIK3C1"
                     /note="Ras binding site [polypeptide binding]; other site"
                     /db_xref="CDD:119433"
     misc_feature    2762..2788
                     /gene="PIK3CB"
                     /gene_synonym="P110BETA; PI3K; PI3KBETA; PIK3C1"
                     /note="catalytic loop [active]"
                     /db_xref="CDD:119433"
     misc_feature    order(2825..2866,2882..2899)
                     /gene="PIK3CB"
                     /gene_synonym="P110BETA; PI3K; PI3KBETA; PIK3C1"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:119433"
     misc_feature    3224..3226
                     /gene="PIK3CB"
                     /gene_synonym="P110BETA; PI3K; PI3KBETA; PIK3C1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine, by autocatalysis; propagated from
                     UniProtKB/Swiss-Prot (P42338.1); phosphorylation site"
     misc_feature    3224..3226
                     /gene="PIK3CB"
                     /gene_synonym="P110BETA; PI3K; PI3KBETA; PIK3C1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     exon            188..413
                     /gene="PIK3CB"
                     /gene_synonym="P110BETA; PI3K; PI3KBETA; PIK3C1"
                     /inference="alignment:Splign:1.39.8"
     variation       250
                     /gene="PIK3CB"
                     /gene_synonym="P110BETA; PI3K; PI3KBETA; PIK3C1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:3729695"
     variation       297
                     /gene="PIK3CB"
                     /gene_synonym="P110BETA; PI3K; PI3KBETA; PIK3C1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:3729696"
     exon            414..637
                     /gene="PIK3CB"
                     /gene_synonym="P110BETA; PI3K; PI3KBETA; PIK3C1"
                     /inference="alignment:Splign:1.39.8"
     exon            638..817
                     /gene="PIK3CB"
                     /gene_synonym="P110BETA; PI3K; PI3KBETA; PIK3C1"
                     /inference="alignment:Splign:1.39.8"
     variation       640
                     /gene="PIK3CB"
                     /gene_synonym="P110BETA; PI3K; PI3KBETA; PIK3C1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:3729699"
     exon            818..988
                     /gene="PIK3CB"
                     /gene_synonym="P110BETA; PI3K; PI3KBETA; PIK3C1"
                     /inference="alignment:Splign:1.39.8"
     exon            989..1066
                     /gene="PIK3CB"
                     /gene_synonym="P110BETA; PI3K; PI3KBETA; PIK3C1"
                     /inference="alignment:Splign:1.39.8"
     exon            1067..1318
                     /gene="PIK3CB"
                     /gene_synonym="P110BETA; PI3K; PI3KBETA; PIK3C1"
                     /inference="alignment:Splign:1.39.8"
     exon            1319..1415
                     /gene="PIK3CB"
                     /gene_synonym="P110BETA; PI3K; PI3KBETA; PIK3C1"
                     /inference="alignment:Splign:1.39.8"
     exon            1416..1546
                     /gene="PIK3CB"
                     /gene_synonym="P110BETA; PI3K; PI3KBETA; PIK3C1"
                     /inference="alignment:Splign:1.39.8"
     variation       1452
                     /gene="PIK3CB"
                     /gene_synonym="P110BETA; PI3K; PI3KBETA; PIK3C1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:3729778"
     exon            1547..1597
                     /gene="PIK3CB"
                     /gene_synonym="P110BETA; PI3K; PI3KBETA; PIK3C1"
                     /inference="alignment:Splign:1.39.8"
     exon            1598..1786
                     /gene="PIK3CB"
                     /gene_synonym="P110BETA; PI3K; PI3KBETA; PIK3C1"
                     /inference="alignment:Splign:1.39.8"
     exon            1787..1908
                     /gene="PIK3CB"
                     /gene_synonym="P110BETA; PI3K; PI3KBETA; PIK3C1"
                     /inference="alignment:Splign:1.39.8"
     variation       1870
                     /gene="PIK3CB"
                     /gene_synonym="P110BETA; PI3K; PI3KBETA; PIK3C1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:3729780"
     variation       1908
                     /gene="PIK3CB"
                     /gene_synonym="P110BETA; PI3K; PI3KBETA; PIK3C1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:3729781"
     exon            1909..2052
                     /gene="PIK3CB"
                     /gene_synonym="P110BETA; PI3K; PI3KBETA; PIK3C1"
                     /inference="alignment:Splign:1.39.8"
     variation       1948
                     /gene="PIK3CB"
                     /gene_synonym="P110BETA; PI3K; PI3KBETA; PIK3C1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:34601499"
     variation       2032
                     /gene="PIK3CB"
                     /gene_synonym="P110BETA; PI3K; PI3KBETA; PIK3C1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:2230462"
     exon            2053..2152
                     /gene="PIK3CB"
                     /gene_synonym="P110BETA; PI3K; PI3KBETA; PIK3C1"
                     /inference="alignment:Splign:1.39.8"
     exon            2153..2331
                     /gene="PIK3CB"
                     /gene_synonym="P110BETA; PI3K; PI3KBETA; PIK3C1"
                     /inference="alignment:Splign:1.39.8"
     variation       2324
                     /gene="PIK3CB"
                     /gene_synonym="P110BETA; PI3K; PI3KBETA; PIK3C1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:3729782"
     exon            2332..2441
                     /gene="PIK3CB"
                     /gene_synonym="P110BETA; PI3K; PI3KBETA; PIK3C1"
                     /inference="alignment:Splign:1.39.8"
     exon            2442..2520
                     /gene="PIK3CB"
                     /gene_synonym="P110BETA; PI3K; PI3KBETA; PIK3C1"
                     /inference="alignment:Splign:1.39.8"
     exon            2521..2688
                     /gene="PIK3CB"
                     /gene_synonym="P110BETA; PI3K; PI3KBETA; PIK3C1"
                     /inference="alignment:Splign:1.39.8"
     exon            2689..2812
                     /gene="PIK3CB"
                     /gene_synonym="P110BETA; PI3K; PI3KBETA; PIK3C1"
                     /inference="alignment:Splign:1.39.8"
     exon            2813..2958
                     /gene="PIK3CB"
                     /gene_synonym="P110BETA; PI3K; PI3KBETA; PIK3C1"
                     /inference="alignment:Splign:1.39.8"
     exon            2959..3091
                     /gene="PIK3CB"
                     /gene_synonym="P110BETA; PI3K; PI3KBETA; PIK3C1"
                     /inference="alignment:Splign:1.39.8"
     exon            3092..5920
                     /gene="PIK3CB"
                     /gene_synonym="P110BETA; PI3K; PI3KBETA; PIK3C1"
                     /inference="alignment:Splign:1.39.8"
     variation       3221
                     /gene="PIK3CB"
                     /gene_synonym="P110BETA; PI3K; PI3KBETA; PIK3C1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:28763907"
     variation       3518
                     /gene="PIK3CB"
                     /gene_synonym="P110BETA; PI3K; PI3KBETA; PIK3C1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:3207549"
     variation       3542
                     /gene="PIK3CB"
                     /gene_synonym="P110BETA; PI3K; PI3KBETA; PIK3C1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11556483"
     STS             3601..3750
                     /gene="PIK3CB"
                     /gene_synonym="P110BETA; PI3K; PI3KBETA; PIK3C1"
                     /standard_name="WI-14619"
                     /db_xref="UniSTS:23063"
     STS             4313..4472
                     /gene="PIK3CB"
                     /gene_synonym="P110BETA; PI3K; PI3KBETA; PIK3C1"
                     /standard_name="RH12673"
                     /db_xref="UniSTS:69144"
     STS             4406..4583
                     /gene="PIK3CB"
                     /gene_synonym="P110BETA; PI3K; PI3KBETA; PIK3C1"
                     /standard_name="SHGC-63"
                     /db_xref="UniSTS:86566"
     variation       5537
                     /gene="PIK3CB"
                     /gene_synonym="P110BETA; PI3K; PI3KBETA; PIK3C1"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:1054068"
ORIGIN      

ggccccgtggttatgaatgtgcttcagtttcataatgcctcctgctatggcagacatccttgacatctgggcggtggattcacagatagcatctgatggctccatacctgtggatttccttttgcccactgggatttatatccagttggaggtacctcgggaagctaccatttcttatattaagcagatgttatggaagcaagttcacaattacccaatgttcaacctccttatggatattgactcctatatgtttgcatgtgtgaatcagactgctgtatatgaggagcttgaagatgaaacacgaagactctgtgatgtcagaccttttcttccagttctcaaattagtgacaagaagttgtgacccaggggaaaaattagactcaaaaattggagtccttataggaaaaggtctgcatgaatttgattccttgaaggatcctgaagtaaatgaatttcgaagaaaaatgcgcaaattcagcgaggaaaaaatcctgtcacttgtgggattgtcttggatggactggctaaaacaaacatatccaccagagcatgaaccatccatccctgaaaacttagaagataaactttatgggggaaagctcatcgtagctgttcattttgaaaactgccaggacgtgtttagctttcaagtgtctcctaatatgaatcctatcaaagtaaatgaattggcaatccaaaaacgtttgactattcatgggaaggaagatgaagttagcccctatgattatgtgttgcaagtcagcgggagagtagaatatgtttttggtgatcatccactaattcagttccagtatatccggaactgtgtgatgaacagagccctgccccattttatacttgtggaatgctgcaagatcaagaaaatgtatgaacaagaaatgattgccatagaggctgccataaatcgaaattcatctaatcttcctcttccattaccaccaaagaaaacacgaattatttctcatgtttgggaaaataacaaccctttccaaattgtcttggttaagggaaataaacttaacacagaggaaactgtaaaagttcatgtcagggctggtctttttcatggtactgagctcctgtgtaaaaccatcgtaagctcagaggtatcagggaaaaatgatcatatttggaatgaaccactggaatttgatattaatatttgtgacttaccaagaatggctcgattatgttttgctgtttatgcagttttggataaagtaaaaacgaagaaatcaacgaaaactattaatccctctaaatatcagaccatcaggaaagctggaaaagtgcattatcctgtagcgtgggtaaatacgatggtttttgactttaaaggacaattgagaactggagacataatattacacagctggtcttcatttcctgatgaactcgaagaaatgttgaatccaatgggaactgttcaaacaaatccatatactgaaaatgcaacagctttgcatgttaaatttccagagaataaaaaacaaccttattattaccctcccttcgataagattattgaaaaggcagctgagattgcaagcagtgatagtgctaatgtgtcaagtcgaggtggaaaaaagtttcttcctgtattgaaagaaatcttggacagggatcccttgtctcaactgtgtgaaaatgaaatggatcttatttggactttgcgacaagactgccgagagattttcccacaatcactgccaaaattactgctgtcaatcaagtggaataaacttgaggatgttgctcagcttcaggcgctgcttcagatttggcctaaactgcccccccgggaggccctagagcttctggatttcaactatccagaccagtacgttcgagaatatgctgtaggctgcctgcgacagatgagtgatgaagaactttctcaatatcttttacaactggtgcaagtgttaaaatatgagccttttcttgattgtgccctctctagattcctattagaaagagcacttggtaatcggaggatagggcagtttctattttggcatcttaggtcagaagtgcacattcctgctgtctcagtacaatttggtgtcatccttgaagcatactgccggggaagtgtggggcacatgaaagtgctttctaagcaggttgaagcactcaataagttaaaaactttaaatagtttaatcaaactgaatgccgtgaagttaaacagagccaaagggaaggaggccatgcatacctgtttaaaacagagtgcttaccgggaagccctctctgacctgcagtcacccctgaacccatgtgttatcctctcagaactctatgttgaaaagtgcaaatacatggattccaaaatgaagcctttgtggctggtatacaataacaaggtatttggtgaggattcagttggagtgatttttaaaaatggtgatgatttacgacaggatatgttgacactccaaatgttgcgcttgatggatttactctggaaagaagctggtttggatcttcggatgttgccttatggctgtttagcaacaggagatcgctctggcctcattgaagttgtgagcacctctgaaacaattgctgacattcagctgaacagtagcaatgtggctgctgcagcagccttcaacaaagatgcccttctgaactggcttaaagaatacaactctggggatgacctggaccgagccattgaggaatttacactgtcctgtgctggctactgtgtagcttcttatgtccttgggattggtgacagacatagtgacaacatcatggtcaaaaaaactggccagctcttccacattgactttggacatattcttggaaatttcaaatctaagtttggcattaaaagggagcgagtgccttttattcttacctatgatttcatccatgtcattcaacaaggaaaaacaggaaatacagaaaagtttggccggttccgccagtgttgtgaggatgcatatctgattttacgacggcatgggaatctcttcatcactctctttgcgctgatgttgactgcagggcttcctgaactcacatcagtcaaagatatacagtatcttaaggactctcttgcattagggaagagtgaagaagaagcactcaaacagtttaagcaaaaatttgatgaggcgctcagggaaagctggactactaaagtgaactggatggcccacacagttcggaaagactacagatcttaacgatcagccttcgctcctaatgtatttgttggtttcatttcattttcattttgcacttgcactaaattgaacatgaccctgttagagatgttataaagggaatgaaatcctggaactcagagttaaattaagaacaaggcatcccacagaacctaatctgaacaatccccgatgattccctctgctttttgaatgcttccaagacttatcatgaaaactgtcaatggataatcatttcctgctgactttgcacgccaaggaatgctactagggattgtttccgtttttgtttgttttttctaatatttggtacttcccagaatggtgtaaatacttcttttcaatgttgtgaccaagtattgtcactcagccaacaacttttccacacctgggggttggtggctgttcttactgtccaaatgaagctaaaaagaaaggcatctttcttcccttttaaaattgtgtaaactgcaaattataatataatttgaatttatgattattttccagaagaaatcttgtaaacctgtggatactcattaattcttttgttaatatttatttccatgatagcatcattccagccagacttgctgaaaatctactggtgaggcaaatataatatatataaatatgctacatatatatttataaaatttctagtgggagttctatataaatgtttctttggtattcttcagcctgtgatttaaagttttacaaaaagcagagctttttcctaagttacttttcagttaggtaactgtgtgatccagttcttccagctgcttctataatgaggcacatattaatacagtttttatatggtatctatgaaagagttcacttcatagagaataatacttgagcaaatgtatccaagaaagcaagcaaatgaaaagaaacctatttatggaataaactccagatctgaaattcagtattttagaaaaatgccagctcttcttactgtatttattaaaacttgtaataatgtgatttttttcaaggatattagttcaaattgaaatggtttcacgccacacggaaatctttaagttatttgttgaggtaccatatatttagggtgctaggggcaagtaatgttaatatgtgcaataggaactactggtttgaatgtgtaaatgggtgatctctctgagtcctggcaacatccagcaaaactactgcttattctccaaagaatattgggagctctcaatcctcggtgatatgggaaagagaactgagtatttgccctatgactgagctttctataggaattttattaaagaatgtttaattttgttgtccttcttaatgttctcagtcaaataaatgagtgagctggtttcggctgctcttggaatgggtgagcctcttctttatgggtagactgggcctttggaacttggcactggaactccaagaaatggccaagtcagtagacaaaccaacctcaggaataggctaaggcttattatggcctcttccctgacttctccccttgtttcccagcctcatcaggcatggtataggaggccccctggactttggtgggagcctgaggtaaggagccatgcatatgggaggtgtcctgaagtctgggtagttacttggcactgagccaaggccagactctgctgctttggagctcttgttcatggggcagatgctggagcagtccagttccttggaaataactcagctgaggatgggagttggcccctgaattcctcatttccagggctggtgtagactcactgagacttccaggaatagaactatggaaggacaggtttgttcagagatctttgtctagtagccacccaccatttcatgaaccaggccgcaggtcagtggtttggagaatggtgaacactgccaggaagaaatggataccattctttccagaggggtctcctcagccaaaaggagggccttgataaatacatgccaaatcagtgaagttcaagtcaactgtttttcccatatgggcaccaaattgtatctttcctgttttctttgaagggttaagtaacgtgaccatagtcacagagtagttgatggagccagtattcaaacccagaaagtaagaagcctattttaattatctgtgctctttactcacaatgcctcagtatacatttcagatttattgggttccacaaatagaaatctatggaaattttgaatcaaattgcattaagctatagacaaggttgagacaaattgacatctccagaatattgagttttccaaaatatgtaagtggagtacccatttatttagattatctttcatttatatccgcaatgatttatagtattctgtgtttacatattatgcatcgtttgttagattcctgggtaagtgactttattgtaagtttcattgttgttaatctatagcaatcattctccaagtgtggtcccctgatgaggagcatcagcatcaccagagagaactggttaaaaatgcaaattcttaatttttaatttttgtgagtacatagtagatatatatatggggtacatggaatattttgatacaggcatataacatgtaattatcgcatcagggtaattggggtatccattacctcaagcatttatcctttgtattagaaacaatccagttatactcttttagttattttaagatctataattaaattatcgactatagttaaaaaaaaaaaa

//

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:5291 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
            GeneID:5291 -> Molecular function: GO:0005524 [ATP binding] evidence: IEA
            GeneID:5291 -> Molecular function: GO:0016303 [1-phosphatidylinositol-3-kinase activity] evidence: IBA
            GeneID:5291 -> Molecular function: GO:0035004 [phosphatidylinositol 3-kinase activity] evidence: TAS
            GeneID:5291 -> Molecular function: GO:0035005 [1-phosphatidylinositol-4-phosphate 3-kinase activity] evidence: IBA
            GeneID:5291 -> Molecular function: GO:0043560 [insulin receptor substrate binding] evidence: IEA
            GeneID:5291 -> Molecular function: GO:0046934 [phosphatidylinositol-4,5-bisphosphate 3-kinase activity] evidence: IBA
            GeneID:5291 -> Biological process: GO:0000187 [activation of MAPK activity] evidence: TAS
            GeneID:5291 -> Biological process: GO:0001952 [regulation of cell-matrix adhesion] evidence: IEA
            GeneID:5291 -> Biological process: GO:0006644 [phospholipid metabolic process] evidence: TAS
            GeneID:5291 -> Biological process: GO:0006661 [phosphatidylinositol biosynthetic process] evidence: TAS
            GeneID:5291 -> Biological process: GO:0006874 [cellular calcium ion homeostasis] evidence: IEA
            GeneID:5291 -> Biological process: GO:0006914 [autophagy] evidence: IEA
            GeneID:5291 -> Biological process: GO:0006935 [chemotaxis] evidence: TAS
            GeneID:5291 -> Biological process: GO:0007156 [homophilic cell adhesion] evidence: IEA
            GeneID:5291 -> Biological process: GO:0007165 [signal transduction] evidence: NAS
            GeneID:5291 -> Biological process: GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] evidence: TAS
            GeneID:5291 -> Biological process: GO:0007173 [epidermal growth factor receptor signaling pathway] evidence: TAS
            GeneID:5291 -> Biological process: GO:0007186 [G-protein coupled receptor signaling pathway] evidence: TAS
            GeneID:5291 -> Biological process: GO:0007596 [blood coagulation] evidence: TAS
            GeneID:5291 -> Biological process: GO:0008286 [insulin receptor signaling pathway] evidence: TAS
            GeneID:5291 -> Biological process: GO:0008543 [fibroblast growth factor receptor signaling pathway] evidence: TAS
            GeneID:5291 -> Biological process: GO:0010508 [positive regulation of autophagy] evidence: TAS
            GeneID:5291 -> Biological process: GO:0014065 [phosphatidylinositol 3-kinase cascade] evidence: TAS
            GeneID:5291 -> Biological process: GO:0016477 [cell migration] evidence: TAS
            GeneID:5291 -> Biological process: GO:0030168 [platelet activation] evidence: TAS
            GeneID:5291 -> Biological process: GO:0038095 [Fc-epsilon receptor signaling pathway] evidence: TAS
            GeneID:5291 -> Biological process: GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis] evidence: TAS
            GeneID:5291 -> Biological process: GO:0040016 [embryonic cleavage] evidence: IEA
            GeneID:5291 -> Biological process: GO:0044281 [small molecule metabolic process] evidence: TAS
            GeneID:5291 -> Biological process: GO:0045087 [innate immune response] evidence: TAS
            GeneID:5291 -> Biological process: GO:0048011 [neurotrophin TRK receptor signaling pathway] evidence: TAS
            GeneID:5291 -> Biological process: GO:0048015 [phosphatidylinositol-mediated signaling] evidence: TAS
            GeneID:5291 -> Biological process: GO:0050852 [T cell receptor signaling pathway] evidence: TAS
            GeneID:5291 -> Biological process: GO:0050900 [leukocyte migration] evidence: TAS
            GeneID:5291 -> Biological process: GO:0070527 [platelet aggregation] evidence: TAS
            GeneID:5291 -> Biological process: GO:2000369 [regulation of clathrin-mediated endocytosis] evidence: TAS
            GeneID:5291 -> Cellular component: GO:0005634 [nucleus] evidence: IEA
            GeneID:5291 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
            GeneID:5291 -> Cellular component: GO:0005886 [plasma membrane] evidence: IBA
            GeneID:5291 -> Cellular component: GO:0005942 [phosphatidylinositol 3-kinase complex] evidence: IBA
ANNOTATIONS from NCBI Entrez Gene (20130726):
            NP_006210 -> EC 2.7.1.153