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2024-03-29 11:25:54, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_006101               2209 bp    mRNA    linear   PRI 02-JUN-2013
DEFINITION  Homo sapiens NDC80 kinetochore complex component (NDC80), mRNA.
ACCESSION   NM_006101
VERSION     NM_006101.2  GI:215820615
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2209)
  AUTHORS   Alushin,G.M., Musinipally,V., Matson,D., Tooley,J., Stukenberg,P.T.
            and Nogales,E.
  TITLE     Multimodal microtubule binding by the Ndc80 kinetochore complex
  JOURNAL   Nat. Struct. Mol. Biol. 19 (11), 1161-1167 (2012)
   PUBMED   23085714
  REMARK    GeneRIF: Ndc80's interaction with either growing or shrinking
            microtubule ends can be tuned by the phosphorylation state of its
            tail.
REFERENCE   2  (bases 1 to 2209)
  AUTHORS   Umbreit,N.T., Gestaut,D.R., Tien,J.F., Vollmar,B.S., Gonen,T.,
            Asbury,C.L. and Davis,T.N.
  TITLE     The Ndc80 kinetochore complex directly modulates microtubule
            dynamics
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 109 (40), 16113-16118 (2012)
   PUBMED   22908300
  REMARK    GeneRIF: The Ndc80 kinetochore complex directly modulates
            microtubule dynamics.
REFERENCE   3  (bases 1 to 2209)
  AUTHORS   Varma,D., Chandrasekaran,S., Sundin,L.J., Reidy,K.T., Wan,X.,
            Chasse,D.A., Nevis,K.R., DeLuca,J.G., Salmon,E.D. and Cook,J.G.
  TITLE     Recruitment of the human Cdt1 replication licensing protein by the
            loop domain of Hec1 is required for stable kinetochore-microtubule
            attachment
  JOURNAL   Nat. Cell Biol. 14 (6), 593-603 (2012)
   PUBMED   22581055
  REMARK    GeneRIF: results support the conclusion that Cdt1 binding to Hec1
            is essential for an extended Ndc80 configuration and stable
            kinetochore-microtubule attachment
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2209)
  AUTHORS   Schleiffer,A., Maier,M., Litos,G., Lampert,F., Hornung,P.,
            Mechtler,K. and Westermann,S.
  TITLE     CENP-T proteins are conserved centromere receptors of the Ndc80
            complex
  JOURNAL   Nat. Cell Biol. 14 (6), 604-613 (2012)
   PUBMED   22561346
  REMARK    GeneRIF: results reveal the molecular function of CENP-T proteins
            and demonstrate how the Ndc80 complex is anchored to centromeres in
            a manner that couples chromosome movement to spindle dynamics
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2209)
  AUTHORS   Sethi,G., Pathak,H.B., Zhang,H., Zhou,Y., Einarson,M.B.,
            Vathipadiekal,V., Gunewardena,S., Birrer,M.J. and Godwin,A.K.
  TITLE     An RNA interference lethality screen of the human druggable genome
            to identify molecular vulnerabilities in epithelial ovarian cancer
  JOURNAL   PLoS ONE 7 (10), E47086 (2012)
   PUBMED   23056589
  REMARK    GeneRIF: NDC80, NUF2 and PTN were significantly aberrantly
            overexpressed in serous adenocarcinomas.
REFERENCE   6  (bases 1 to 2209)
  AUTHORS   Zheng,L., Chen,Y., Riley,D.J., Chen,P.L. and Lee,W.H.
  TITLE     Retinoblastoma protein enhances the fidelity of chromosome
            segregation mediated by hsHec1p
  JOURNAL   Mol. Cell. Biol. 20 (10), 3529-3537 (2000)
   PUBMED   10779342
REFERENCE   7  (bases 1 to 2209)
  AUTHORS   Zheng,L., Chen,Y. and Lee,W.H.
  TITLE     Hec1p, an evolutionarily conserved coiled-coil protein, modulates
            chromosome segregation through interaction with SMC proteins
  JOURNAL   Mol. Cell. Biol. 19 (8), 5417-5428 (1999)
   PUBMED   10409732
REFERENCE   8  (bases 1 to 2209)
  AUTHORS   Chen,Y., Riley,D.J., Chen,P.L. and Lee,W.H.
  TITLE     HEC, a novel nuclear protein rich in leucine heptad repeats
            specifically involved in mitosis
  JOURNAL   Mol. Cell. Biol. 17 (10), 6049-6056 (1997)
   PUBMED   9315664
REFERENCE   9  (bases 1 to 2209)
  AUTHORS   Chen,Y., Sharp,Z.D. and Lee,W.H.
  TITLE     HEC binds to the seventh regulatory subunit of the 26 S proteasome
            and modulates the proteolysis of mitotic cyclins
  JOURNAL   J. Biol. Chem. 272 (38), 24081-24087 (1997)
   PUBMED   9295362
REFERENCE   10 (bases 1 to 2209)
  AUTHORS   Durfee,T., Becherer,K., Chen,P.L., Yeh,S.H., Yang,Y., Kilburn,A.E.,
            Lee,W.H. and Elledge,S.J.
  TITLE     The retinoblastoma protein associates with the protein phosphatase
            type 1 catalytic subunit
  JOURNAL   Genes Dev. 7 (4), 555-569 (1993)
   PUBMED   8384581
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AP005136.2 and BC035617.1.
            On Dec 5, 2008 this sequence version replaced gi:5174456.
            
            Summary: This gene encodes a component of the NDC80 kinetochore
            complex. The encoded protein consists of an N-terminal microtubule
            binding domain and a C-terminal coiled-coiled domain that interacts
            with other components of the complex. This protein functions to
            organize and stabilize microtubule-kinetochore interactions and is
            required for proper chromosome segregation. [provided by RefSeq,
            Oct 2011].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC035617.1, AK289396.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           ERS025084, ERS025085 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-69                AP005136.2         146966-147034
            70-2209             BC035617.1         1-2140
FEATURES             Location/Qualifiers
     source          1..2209
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="18"
                     /map="18p11.32"
     gene            1..2209
                     /gene="NDC80"
                     /gene_synonym="HEC; HEC1; HsHec1; hsNDC80; KNTC2; TID3"
                     /note="NDC80 kinetochore complex component"
                     /db_xref="GeneID:10403"
                     /db_xref="HGNC:16909"
                     /db_xref="HPRD:06277"
                     /db_xref="MIM:607272"
     exon            1..173
                     /gene="NDC80"
                     /gene_synonym="HEC; HEC1; HsHec1; hsNDC80; KNTC2; TID3"
                     /inference="alignment:Splign:1.39.8"
     variation       3
                     /gene="NDC80"
                     /gene_synonym="HEC; HEC1; HsHec1; hsNDC80; KNTC2; TID3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:116539418"
     variation       30
                     /gene="NDC80"
                     /gene_synonym="HEC; HEC1; HsHec1; hsNDC80; KNTC2; TID3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:141384921"
     variation       38
                     /gene="NDC80"
                     /gene_synonym="HEC; HEC1; HsHec1; hsNDC80; KNTC2; TID3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:372578311"
     variation       52
                     /gene="NDC80"
                     /gene_synonym="HEC; HEC1; HsHec1; hsNDC80; KNTC2; TID3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:146984892"
     variation       60
                     /gene="NDC80"
                     /gene_synonym="HEC; HEC1; HsHec1; hsNDC80; KNTC2; TID3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:374492220"
     variation       80
                     /gene="NDC80"
                     /gene_synonym="HEC; HEC1; HsHec1; hsNDC80; KNTC2; TID3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:137961688"
     misc_feature    93..95
                     /gene="NDC80"
                     /gene_synonym="HEC; HEC1; HsHec1; hsNDC80; KNTC2; TID3"
                     /note="upstream in-frame stop codon"
     variation       124
                     /gene="NDC80"
                     /gene_synonym="HEC; HEC1; HsHec1; hsNDC80; KNTC2; TID3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:113590445"
     variation       145
                     /gene="NDC80"
                     /gene_synonym="HEC; HEC1; HsHec1; hsNDC80; KNTC2; TID3"
                     /replace="a"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:371355851"
     exon            174..283
                     /gene="NDC80"
                     /gene_synonym="HEC; HEC1; HsHec1; hsNDC80; KNTC2; TID3"
                     /inference="alignment:Splign:1.39.8"
     CDS             183..2111
                     /gene="NDC80"
                     /gene_synonym="HEC; HEC1; HsHec1; hsNDC80; KNTC2; TID3"
                     /note="highly expressed in cancer, rich in leucine heptad
                     repeats; kinetochore associated 2; NDC80 homolog,
                     kinetochore complex component; NDC80 kinetochore complex
                     component homolog; kinetochore protein Hec1;
                     kinetochore-associated protein 2; highly expressed in
                     cancer protein; retinoblastoma-associated protein HEC"
                     /codon_start=1
                     /product="kinetochore protein NDC80 homolog"
                     /protein_id="NP_006092.1"
                     /db_xref="GI:5174457"
                     /db_xref="CCDS:CCDS11827.1"
                     /db_xref="GeneID:10403"
                     /db_xref="HGNC:16909"
                     /db_xref="HPRD:06277"
                     /db_xref="MIM:607272"
                     /translation="
MKRSSVSSGGAGRLSMQELRSQDVNKQGLYTPQTKEKPTFGKLSINKPTSERKVSLFGKRTSGHGSRNSQLGIFSSSEKIKDPRPLNDKAFIQQCIRQLCEFLTENGYAHNVSMKSLQAPSVKDFLKIFTFLYGFLCPSYELPDTKFEEEVPRIFKDLGYPFALSKSSMYTVGAPHTWPHIVAALVWLIDCIKIHTAMKESSPLFDDGQPWGEETEDGIMHNKLFLDYTIKCYESFMSGADSFDEMNAELQSKLKDLFNVDAFKLESLEAKNRALNEQIARLEQEREKEPNRLESLRKLKASLQGDVQKYQAYMSNLESHSAILDQKLNGLNEEIARVELECETIKQENTRLQNIIDNQKYSVADIERINHERNELQQTINKLTKDLEAEQQKLWNEELKYARGKEAIETQLAEYHKLARKLKLIPKGAENSKGYDFEIKFNPEAGANCLVKYRAQVYVPLKELLNETEEEINKALNKKMGLEDTLEQLNAMITESKRSVRTLKEEVQKLDDLYQQKIKEAEEEDEKCASELESLEKHKHLLESTVNQGLSEAMNELDAVQREYQLVVQTTTEERRKVGNNLQRLLEMVATHVGSVEKHLEEQIAKVDREYEECMSEDLSENIKEIRDKYEKKATLIKSSEE
"
     misc_feature    183..1733
                     /gene="NDC80"
                     /gene_synonym="HEC; HEC1; HsHec1; hsNDC80; KNTC2; TID3"
                     /note="Protein involved in chromosome segregation,
                     interacts with SMC proteins [Cell division and chromosome
                     partitioning]; Region: HEC1; COG5185"
                     /db_xref="CDD:34784"
     misc_feature    183..1517
                     /gene="NDC80"
                     /gene_synonym="HEC; HEC1; HsHec1; hsNDC80; KNTC2; TID3"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (O14777.1);
                     Region: Interaction with the N-terminus of CDCA1"
     misc_feature    183..932
                     /gene="NDC80"
                     /gene_synonym="HEC; HEC1; HsHec1; hsNDC80; KNTC2; TID3"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (O14777.1);
                     Region: Nuclear localization"
     misc_feature    327..827
                     /gene="NDC80"
                     /gene_synonym="HEC; HEC1; HsHec1; hsNDC80; KNTC2; TID3"
                     /note="HEC/Ndc80p family; Region: Ndc80_HEC; pfam03801"
                     /db_xref="CDD:190756"
     misc_feature    345..347
                     /gene="NDC80"
                     /gene_synonym="HEC; HEC1; HsHec1; hsNDC80; KNTC2; TID3"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     misc_feature    366..368
                     /gene="NDC80"
                     /gene_synonym="HEC; HEC1; HsHec1; hsNDC80; KNTC2; TID3"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     misc_feature    387..389
                     /gene="NDC80"
                     /gene_synonym="HEC; HEC1; HsHec1; hsNDC80; KNTC2; TID3"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (O14777.1); phosphorylation site"
     misc_feature    408..410
                     /gene="NDC80"
                     /gene_synonym="HEC; HEC1; HsHec1; hsNDC80; KNTC2; TID3"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     misc_feature    411..413
                     /gene="NDC80"
                     /gene_synonym="HEC; HEC1; HsHec1; hsNDC80; KNTC2; TID3"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     misc_feature    564..935
                     /gene="NDC80"
                     /gene_synonym="HEC; HEC1; HsHec1; hsNDC80; KNTC2; TID3"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (O14777.1);
                     Region: Interaction with RB1"
     misc_feature    675..677
                     /gene="NDC80"
                     /gene_synonym="HEC; HEC1; HsHec1; hsNDC80; KNTC2; TID3"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine, by NEK2; propagated from
                     UniProtKB/Swiss-Prot (O14777.1); phosphorylation site"
     misc_feature    675..677
                     /gene="NDC80"
                     /gene_synonym="HEC; HEC1; HsHec1; hsNDC80; KNTC2; TID3"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
                     /db_xref="HPRD:04953"
     misc_feature    933..2036
                     /gene="NDC80"
                     /gene_synonym="HEC; HEC1; HsHec1; hsNDC80; KNTC2; TID3"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (O14777.1);
                     Region: Interaction with NEK2 and ZWINT"
     misc_feature    933..1475
                     /gene="NDC80"
                     /gene_synonym="HEC; HEC1; HsHec1; hsNDC80; KNTC2; TID3"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (O14777.1);
                     Region: Interaction with SMC1A"
     misc_feature    1263..1823
                     /gene="NDC80"
                     /gene_synonym="HEC; HEC1; HsHec1; hsNDC80; KNTC2; TID3"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (O14777.1);
                     Region: Interaction with PSMC2 and SMC1A"
     misc_feature    1518..2108
                     /gene="NDC80"
                     /gene_synonym="HEC; HEC1; HsHec1; hsNDC80; KNTC2; TID3"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (O14777.1);
                     Region: Interaction with the C-terminus of CDCA1 and the
                     SPBC24-SPBC25 subcomplex"
     variation       206
                     /gene="NDC80"
                     /gene_synonym="HEC; HEC1; HsHec1; hsNDC80; KNTC2; TID3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:374603804"
     variation       220
                     /gene="NDC80"
                     /gene_synonym="HEC; HEC1; HsHec1; hsNDC80; KNTC2; TID3"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:368528456"
     variation       265
                     /gene="NDC80"
                     /gene_synonym="HEC; HEC1; HsHec1; hsNDC80; KNTC2; TID3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:147021077"
     variation       269
                     /gene="NDC80"
                     /gene_synonym="HEC; HEC1; HsHec1; hsNDC80; KNTC2; TID3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:112843016"
     variation       274
                     /gene="NDC80"
                     /gene_synonym="HEC; HEC1; HsHec1; hsNDC80; KNTC2; TID3"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:371386396"
     variation       277
                     /gene="NDC80"
                     /gene_synonym="HEC; HEC1; HsHec1; hsNDC80; KNTC2; TID3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200135694"
     exon            284..361
                     /gene="NDC80"
                     /gene_synonym="HEC; HEC1; HsHec1; hsNDC80; KNTC2; TID3"
                     /inference="alignment:Splign:1.39.8"
     variation       326
                     /gene="NDC80"
                     /gene_synonym="HEC; HEC1; HsHec1; hsNDC80; KNTC2; TID3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:372232106"
     variation       345
                     /gene="NDC80"
                     /gene_synonym="HEC; HEC1; HsHec1; hsNDC80; KNTC2; TID3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:375240200"
     variation       347
                     /gene="NDC80"
                     /gene_synonym="HEC; HEC1; HsHec1; hsNDC80; KNTC2; TID3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:369863089"
     exon            362..485
                     /gene="NDC80"
                     /gene_synonym="HEC; HEC1; HsHec1; hsNDC80; KNTC2; TID3"
                     /inference="alignment:Splign:1.39.8"
     variation       362
                     /gene="NDC80"
                     /gene_synonym="HEC; HEC1; HsHec1; hsNDC80; KNTC2; TID3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:149357717"
     variation       378
                     /gene="NDC80"
                     /gene_synonym="HEC; HEC1; HsHec1; hsNDC80; KNTC2; TID3"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:16943490"
     variation       430
                     /gene="NDC80"
                     /gene_synonym="HEC; HEC1; HsHec1; hsNDC80; KNTC2; TID3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:199533479"
     variation       431
                     /gene="NDC80"
                     /gene_synonym="HEC; HEC1; HsHec1; hsNDC80; KNTC2; TID3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:148077669"
     variation       464
                     /gene="NDC80"
                     /gene_synonym="HEC; HEC1; HsHec1; hsNDC80; KNTC2; TID3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:377276946"
     exon            486..658
                     /gene="NDC80"
                     /gene_synonym="HEC; HEC1; HsHec1; hsNDC80; KNTC2; TID3"
                     /inference="alignment:Splign:1.39.8"
     variation       546
                     /gene="NDC80"
                     /gene_synonym="HEC; HEC1; HsHec1; hsNDC80; KNTC2; TID3"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:142862448"
     variation       564
                     /gene="NDC80"
                     /gene_synonym="HEC; HEC1; HsHec1; hsNDC80; KNTC2; TID3"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:367674640"
     variation       575..576
                     /gene="NDC80"
                     /gene_synonym="HEC; HEC1; HsHec1; hsNDC80; KNTC2; TID3"
                     /replace=""
                     /replace="t"
                     /db_xref="dbSNP:35658657"
     variation       615
                     /gene="NDC80"
                     /gene_synonym="HEC; HEC1; HsHec1; hsNDC80; KNTC2; TID3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:376046223"
     exon            659..761
                     /gene="NDC80"
                     /gene_synonym="HEC; HEC1; HsHec1; hsNDC80; KNTC2; TID3"
                     /inference="alignment:Splign:1.39.8"
     variation       675
                     /gene="NDC80"
                     /gene_synonym="HEC; HEC1; HsHec1; hsNDC80; KNTC2; TID3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:369783870"
     variation       742
                     /gene="NDC80"
                     /gene_synonym="HEC; HEC1; HsHec1; hsNDC80; KNTC2; TID3"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:79077391"
     exon            762..851
                     /gene="NDC80"
                     /gene_synonym="HEC; HEC1; HsHec1; hsNDC80; KNTC2; TID3"
                     /inference="alignment:Splign:1.39.8"
     variation       767
                     /gene="NDC80"
                     /gene_synonym="HEC; HEC1; HsHec1; hsNDC80; KNTC2; TID3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:377476640"
     variation       783
                     /gene="NDC80"
                     /gene_synonym="HEC; HEC1; HsHec1; hsNDC80; KNTC2; TID3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201008129"
     variation       812
                     /gene="NDC80"
                     /gene_synonym="HEC; HEC1; HsHec1; hsNDC80; KNTC2; TID3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:372968640"
     variation       830
                     /gene="NDC80"
                     /gene_synonym="HEC; HEC1; HsHec1; hsNDC80; KNTC2; TID3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:146077109"
     exon            852..945
                     /gene="NDC80"
                     /gene_synonym="HEC; HEC1; HsHec1; hsNDC80; KNTC2; TID3"
                     /inference="alignment:Splign:1.39.8"
     variation       866
                     /gene="NDC80"
                     /gene_synonym="HEC; HEC1; HsHec1; hsNDC80; KNTC2; TID3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:74873324"
     variation       871
                     /gene="NDC80"
                     /gene_synonym="HEC; HEC1; HsHec1; hsNDC80; KNTC2; TID3"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:199597516"
     variation       903
                     /gene="NDC80"
                     /gene_synonym="HEC; HEC1; HsHec1; hsNDC80; KNTC2; TID3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:371134043"
     exon            946..1052
                     /gene="NDC80"
                     /gene_synonym="HEC; HEC1; HsHec1; hsNDC80; KNTC2; TID3"
                     /inference="alignment:Splign:1.39.8"
     variation       970
                     /gene="NDC80"
                     /gene_synonym="HEC; HEC1; HsHec1; hsNDC80; KNTC2; TID3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:367863450"
     variation       973
                     /gene="NDC80"
                     /gene_synonym="HEC; HEC1; HsHec1; hsNDC80; KNTC2; TID3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:142132120"
     variation       982
                     /gene="NDC80"
                     /gene_synonym="HEC; HEC1; HsHec1; hsNDC80; KNTC2; TID3"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:150913539"
     variation       1028
                     /gene="NDC80"
                     /gene_synonym="HEC; HEC1; HsHec1; hsNDC80; KNTC2; TID3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:139422913"
     variation       1031
                     /gene="NDC80"
                     /gene_synonym="HEC; HEC1; HsHec1; hsNDC80; KNTC2; TID3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:150053394"
     exon            1053..1197
                     /gene="NDC80"
                     /gene_synonym="HEC; HEC1; HsHec1; hsNDC80; KNTC2; TID3"
                     /inference="alignment:Splign:1.39.8"
     variation       1067
                     /gene="NDC80"
                     /gene_synonym="HEC; HEC1; HsHec1; hsNDC80; KNTC2; TID3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:144899651"
     variation       1082
                     /gene="NDC80"
                     /gene_synonym="HEC; HEC1; HsHec1; hsNDC80; KNTC2; TID3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:140253066"
     variation       1122
                     /gene="NDC80"
                     /gene_synonym="HEC; HEC1; HsHec1; hsNDC80; KNTC2; TID3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:144356414"
     variation       1196
                     /gene="NDC80"
                     /gene_synonym="HEC; HEC1; HsHec1; hsNDC80; KNTC2; TID3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:34616574"
     exon            1198..1403
                     /gene="NDC80"
                     /gene_synonym="HEC; HEC1; HsHec1; hsNDC80; KNTC2; TID3"
                     /inference="alignment:Splign:1.39.8"
     variation       1226
                     /gene="NDC80"
                     /gene_synonym="HEC; HEC1; HsHec1; hsNDC80; KNTC2; TID3"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:12456560"
     variation       1246
                     /gene="NDC80"
                     /gene_synonym="HEC; HEC1; HsHec1; hsNDC80; KNTC2; TID3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:372864107"
     variation       1285
                     /gene="NDC80"
                     /gene_synonym="HEC; HEC1; HsHec1; hsNDC80; KNTC2; TID3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:116875769"
     variation       1310
                     /gene="NDC80"
                     /gene_synonym="HEC; HEC1; HsHec1; hsNDC80; KNTC2; TID3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:191627383"
     variation       1402
                     /gene="NDC80"
                     /gene_synonym="HEC; HEC1; HsHec1; hsNDC80; KNTC2; TID3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:377218212"
     exon            1404..1556
                     /gene="NDC80"
                     /gene_synonym="HEC; HEC1; HsHec1; hsNDC80; KNTC2; TID3"
                     /inference="alignment:Splign:1.39.8"
     variation       1410
                     /gene="NDC80"
                     /gene_synonym="HEC; HEC1; HsHec1; hsNDC80; KNTC2; TID3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201862820"
     variation       1465
                     /gene="NDC80"
                     /gene_synonym="HEC; HEC1; HsHec1; hsNDC80; KNTC2; TID3"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:150976216"
     variation       1490
                     /gene="NDC80"
                     /gene_synonym="HEC; HEC1; HsHec1; hsNDC80; KNTC2; TID3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:140891179"
     variation       1508
                     /gene="NDC80"
                     /gene_synonym="HEC; HEC1; HsHec1; hsNDC80; KNTC2; TID3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201439100"
     variation       1537
                     /gene="NDC80"
                     /gene_synonym="HEC; HEC1; HsHec1; hsNDC80; KNTC2; TID3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:35226605"
     exon            1557..1646
                     /gene="NDC80"
                     /gene_synonym="HEC; HEC1; HsHec1; hsNDC80; KNTC2; TID3"
                     /inference="alignment:Splign:1.39.8"
     variation       1557
                     /gene="NDC80"
                     /gene_synonym="HEC; HEC1; HsHec1; hsNDC80; KNTC2; TID3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:370607967"
     variation       1562
                     /gene="NDC80"
                     /gene_synonym="HEC; HEC1; HsHec1; hsNDC80; KNTC2; TID3"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:2271756"
     variation       1563
                     /gene="NDC80"
                     /gene_synonym="HEC; HEC1; HsHec1; hsNDC80; KNTC2; TID3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200355974"
     variation       1568
                     /gene="NDC80"
                     /gene_synonym="HEC; HEC1; HsHec1; hsNDC80; KNTC2; TID3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:78415954"
     variation       1597
                     /gene="NDC80"
                     /gene_synonym="HEC; HEC1; HsHec1; hsNDC80; KNTC2; TID3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:150156156"
     exon            1647..1739
                     /gene="NDC80"
                     /gene_synonym="HEC; HEC1; HsHec1; hsNDC80; KNTC2; TID3"
                     /inference="alignment:Splign:1.39.8"
     variation       1686
                     /gene="NDC80"
                     /gene_synonym="HEC; HEC1; HsHec1; hsNDC80; KNTC2; TID3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:138149021"
     exon            1740..1870
                     /gene="NDC80"
                     /gene_synonym="HEC; HEC1; HsHec1; hsNDC80; KNTC2; TID3"
                     /inference="alignment:Splign:1.39.8"
     variation       1770
                     /gene="NDC80"
                     /gene_synonym="HEC; HEC1; HsHec1; hsNDC80; KNTC2; TID3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:34184740"
     variation       1777
                     /gene="NDC80"
                     /gene_synonym="HEC; HEC1; HsHec1; hsNDC80; KNTC2; TID3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:111250874"
     variation       1803
                     /gene="NDC80"
                     /gene_synonym="HEC; HEC1; HsHec1; hsNDC80; KNTC2; TID3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201157769"
     variation       1829
                     /gene="NDC80"
                     /gene_synonym="HEC; HEC1; HsHec1; hsNDC80; KNTC2; TID3"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:368370939"
     variation       1844
                     /gene="NDC80"
                     /gene_synonym="HEC; HEC1; HsHec1; hsNDC80; KNTC2; TID3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:145075027"
     exon            1871..1973
                     /gene="NDC80"
                     /gene_synonym="HEC; HEC1; HsHec1; hsNDC80; KNTC2; TID3"
                     /inference="alignment:Splign:1.39.8"
     variation       1878
                     /gene="NDC80"
                     /gene_synonym="HEC; HEC1; HsHec1; hsNDC80; KNTC2; TID3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:190623140"
     variation       1895
                     /gene="NDC80"
                     /gene_synonym="HEC; HEC1; HsHec1; hsNDC80; KNTC2; TID3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:138857521"
     variation       1898
                     /gene="NDC80"
                     /gene_synonym="HEC; HEC1; HsHec1; hsNDC80; KNTC2; TID3"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:377269716"
     variation       1908
                     /gene="NDC80"
                     /gene_synonym="HEC; HEC1; HsHec1; hsNDC80; KNTC2; TID3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:142173030"
     variation       1915
                     /gene="NDC80"
                     /gene_synonym="HEC; HEC1; HsHec1; hsNDC80; KNTC2; TID3"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:368687099"
     variation       1933
                     /gene="NDC80"
                     /gene_synonym="HEC; HEC1; HsHec1; hsNDC80; KNTC2; TID3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:144795559"
     variation       1938
                     /gene="NDC80"
                     /gene_synonym="HEC; HEC1; HsHec1; hsNDC80; KNTC2; TID3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:112036437"
     variation       1963
                     /gene="NDC80"
                     /gene_synonym="HEC; HEC1; HsHec1; hsNDC80; KNTC2; TID3"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:201624661"
     variation       1970
                     /gene="NDC80"
                     /gene_synonym="HEC; HEC1; HsHec1; hsNDC80; KNTC2; TID3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:60195684"
     exon            1974..2172
                     /gene="NDC80"
                     /gene_synonym="HEC; HEC1; HsHec1; hsNDC80; KNTC2; TID3"
                     /inference="alignment:Splign:1.39.8"
     variation       1995
                     /gene="NDC80"
                     /gene_synonym="HEC; HEC1; HsHec1; hsNDC80; KNTC2; TID3"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:9051"
     variation       2020
                     /gene="NDC80"
                     /gene_synonym="HEC; HEC1; HsHec1; hsNDC80; KNTC2; TID3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:371426220"
     variation       2029
                     /gene="NDC80"
                     /gene_synonym="HEC; HEC1; HsHec1; hsNDC80; KNTC2; TID3"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:150692122"
     variation       2038
                     /gene="NDC80"
                     /gene_synonym="HEC; HEC1; HsHec1; hsNDC80; KNTC2; TID3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:187649956"
     variation       2112..2113
                     /gene="NDC80"
                     /gene_synonym="HEC; HEC1; HsHec1; hsNDC80; KNTC2; TID3"
                     /replace=""
                     /replace="a"
                     /db_xref="dbSNP:36027190"
     variation       2119
                     /gene="NDC80"
                     /gene_synonym="HEC; HEC1; HsHec1; hsNDC80; KNTC2; TID3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200601203"
ORIGIN      
actgcgcgcgtcgtgcgtaatgacgtcagcgccggcggagaatttcaaattcgaacggctttggcgggccgaggaaggacctggtgttttgatgaccgctgtcctgtctagcagatacttgcacggtttacagaaattcggtccctgggtcgtgtcaggaaactggaaaaaaggtcataagcatgaagcgcagttcagtttccagcggtggtgctggccgcctctccatgcaggagttaagatcccaggatgtaaataaacaaggcctctatacccctcaaaccaaagagaaaccaacctttggaaagttgagtataaacaaaccgacatctgaaagaaaagtctcgctatttggcaaaagaactagtggacatggatcccggaatagtcaacttggtatattttccagttctgagaaaatcaaggacccgagaccacttaatgacaaagcattcattcagcagtgtattcgacaactctgtgagtttcttacagaaaatggttatgcacataatgtgtccatgaaatctctacaagctccctctgttaaagacttcctgaagatcttcacatttctttatggcttcctgtgcccctcatacgaacttcctgacacaaagtttgaagaagaggttccaagaatctttaaagaccttgggtatccttttgcactatccaaaagctccatgtacacagtgggggctcctcatacatggcctcacattgtggcagccttagtttggctaatagactgcatcaagatacatactgccatgaaagaaagctcacctttatttgatgatgggcagccttggggagaagaaactgaagatggaattatgcataataagttgtttttggactacaccataaaatgctatgagagttttatgagtggtgccgacagctttgatgagatgaatgcagagctgcagtcaaaactgaaggatttatttaatgtggatgcttttaagctggaatcattagaagcaaaaaacagagcattgaatgaacagattgcaagattggaacaagaaagagaaaaagaaccgaatcgtctagagtcgttgagaaaactgaaggcttccttacaaggagatgttcaaaagtatcaggcatacatgagcaatttggagtctcattcagccattcttgaccagaaattaaatggtctcaatgaggaaattgctagagtagaactagaatgtgaaacaataaaacaggagaacactcgactacagaatatcattgacaaccagaagtactcagttgcagacattgagcgaataaatcatgaaagaaatgaattgcagcagactattaataaattaaccaaggacctggaagctgaacaacagaagttgtggaatgaggagttaaaatatgccagaggcaaagaagcgattgaaacacaattagcagagtatcacaaattggctagaaaattaaaacttattcctaaaggtgctgagaattccaaaggttatgactttgaaattaagtttaatcccgaggctggtgccaactgccttgtcaaatacagggctcaagtttatgtacctcttaaggaactcctgaatgaaactgaagaagaaattaataaagccctaaataaaaaaatgggtttggaggatactttagaacaattgaatgcaatgataacagaaagcaagagaagtgtgagaactctgaaagaagaagttcaaaagctggatgatctttaccaacaaaaaattaaggaagcagaggaagaggatgaaaaatgtgccagtgagcttgagtccttggagaaacacaagcacctgctagaaagtactgttaaccaggggctcagtgaagctatgaatgaattagatgctgttcagcgggaataccaactagttgtgcaaaccacgactgaagaaagacgaaaagtgggaaataacttgcaacgtctgttagagatggttgctacacatgttgggtctgtagagaaacatcttgaggagcagattgctaaagttgatagagaatatgaagaatgcatgtcagaagatctctcggaaaatattaaagagattagagataagtatgagaagaaagctactctaattaagtcttctgaagaatgaagataaaatgttgatcatgtatatatatccatagtgaataaaattgtctcagtaaagtgtaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:10403 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
            GeneID:10403 -> Biological process: GO:0000070 [mitotic sister chromatid segregation] evidence: TAS
            GeneID:10403 -> Biological process: GO:0000132 [establishment of mitotic spindle orientation] evidence: IMP
            GeneID:10403 -> Biological process: GO:0000278 [mitotic cell cycle] evidence: TAS
            GeneID:10403 -> Biological process: GO:0007049 [cell cycle] evidence: NAS
            GeneID:10403 -> Biological process: GO:0007051 [spindle organization] evidence: NAS
            GeneID:10403 -> Biological process: GO:0007052 [mitotic spindle organization] evidence: IMP
            GeneID:10403 -> Biological process: GO:0007059 [chromosome segregation] evidence: IMP
            GeneID:10403 -> Biological process: GO:0007067 [mitosis] evidence: TAS
            GeneID:10403 -> Biological process: GO:0008608 [attachment of spindle microtubules to kinetochore] evidence: IMP
            GeneID:10403 -> Biological process: GO:0048015 [phosphatidylinositol-mediated signaling] evidence: NAS
            GeneID:10403 -> Biological process: GO:0051301 [cell division] evidence: IEA
            GeneID:10403 -> Cellular component: GO:0000775 [chromosome, centromeric region] evidence: TAS
            GeneID:10403 -> Cellular component: GO:0000776 [kinetochore] evidence: IDA
            GeneID:10403 -> Cellular component: GO:0000777 [condensed chromosome kinetochore] evidence: IDA
            GeneID:10403 -> Cellular component: GO:0000942 [condensed nuclear chromosome outer kinetochore] evidence: IDA
            GeneID:10403 -> Cellular component: GO:0005634 [nucleus] evidence: TAS
            GeneID:10403 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
            GeneID:10403 -> Cellular component: GO:0031262 [Ndc80 complex] evidence: IDA

by @meso_cacase at DBCLS
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