GGRNA | NM_005924.4

LOCUS       NM_005924               2383 bp    mRNA    linear   PRI 17-APR-2013
DEFINITION  Homo sapiens mesenchyme homeobox 2 (MEOX2), mRNA.
ACCESSION   NM_005924
VERSION     NM_005924.4  GI:84105334
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2383)
  AUTHORS   Douville,J.M., Cheung,D.Y., Herbert,K.L., Moffatt,T. and Wigle,J.T.
  TITLE     Mechanisms of MEOX1 and MEOX2 regulation of the cyclin dependent
            kinase inhibitors p21 and p16 in vascular endothelial cells
  JOURNAL   PLoS ONE 6 (12), E29099 (2011)
   PUBMED   22206000
  REMARK    GeneRIF: MEOX1 and MEOX2 activate p16(INK4a) in a DNA binding
            dependent manner, whereas they induce p21(CIP1/WAF1) in a DNA
            binding independent manner.
REFERENCE   2  (bases 1 to 2383)
  AUTHORS   Chen,Y., Rabson,A.B. and Gorski,D.H.
  TITLE     MEOX2 regulates nuclear factor-kappaB activity in vascular
            endothelial cells through interactions with p65 and IkappaBbeta
  JOURNAL   Cardiovasc. Res. 87 (4), 723-731 (2010)
   PUBMED   20421348
  REMARK    GeneRIF: Report of an interaction between a homeobox protein and
            IkappaBbeta in endothelial cells and suggest that MEOX2 modulates
            the activity of the RelA complex through direct interaction with
            its components.
REFERENCE   3  (bases 1 to 2383)
  AUTHORS   Ohshima,J., Haruta,M., Arai,Y., Kasai,F., Fujiwara,Y., Ariga,T.,
            Okita,H., Fukuzawa,M., Hata,J., Horie,H. and Kaneko,Y.
  TITLE     Two candidate tumor suppressor genes, MEOX2 and SOSTDC1, identified
            in a 7p21 homozygous deletion region in a Wilms tumor
  JOURNAL   Genes Chromosomes Cancer 48 (12), 1037-1050 (2009)
   PUBMED   19760604
  REMARK    GeneRIF: Loss of MEOX2 gene is associated with Wilms tumor.
REFERENCE   4  (bases 1 to 2383)
  AUTHORS   Irelan,J.T., Gutierrez Del Arroyo,A., Gutierrez,A., Peters,G.,
            Quon,K.C., Miraglia,L. and Chanda,S.K.
  TITLE     A functional screen for regulators of CKDN2A reveals MEOX2 as a
            transcriptional activator of INK4a
  JOURNAL   PLoS ONE 4 (4), E5067 (2009)
   PUBMED   19340300
  REMARK    GeneRIF: MEOX2-induced senescence is dependent upon INK4a activity,
            and chromatin immunoprecipitation studies indicate that MEOX2
            directly binds the INK4a promoter
REFERENCE   5  (bases 1 to 2383)
  AUTHORS   Valcourt,U., Thuault,S., Pardali,K., Heldin,C.H. and Moustakas,A.
  TITLE     Functional role of Meox2 during the epithelial cytostatic response
            to TGF-beta
  JOURNAL   Mol Oncol 1 (1), 55-71 (2007)
   PUBMED   19383287
  REMARK    GeneRIF: ectopic Meox2 suppressed epithelial cell proliferation in
            cooperation with TGF-beta1, and mediated induction of the cell
            cycle inhibitor gene p21.
REFERENCE   6  (bases 1 to 2383)
  AUTHORS   Quinn,L.M., Latham,S.E. and Kalionis,B.
  TITLE     The homeobox genes MSX2 and MOX2 are candidates for regulating
            epithelial-mesenchymal cell interactions in the human placenta
  JOURNAL   Placenta 21 (SUPPL A), S50-S54 (2000)
   PUBMED   10831122
REFERENCE   7  (bases 1 to 2383)
  AUTHORS   Quinn,L.M., Johnson,B.V., Nicholl,J., Sutherland,G.R. and
            Kalionis,B.
  TITLE     Isolation and identification of homeobox genes from the human
            placenta including a novel member of the Distal-less family, DLX4
  JOURNAL   Gene 187 (1), 55-61 (1997)
   PUBMED   9073066
REFERENCE   8  (bases 1 to 2383)
  AUTHORS   Grigoriou,M., Kastrinaki,M.C., Modi,W.S., Theodorakis,K.,
            Mankoo,B., Pachnis,V. and Karagogeos,D.
  TITLE     Isolation of the human MOX2 homeobox gene and localization to
            chromosome 7p22.1-p21.3
  JOURNAL   Genomics 26 (3), 550-555 (1995)
   PUBMED   7607679
REFERENCE   9  (bases 1 to 2383)
  AUTHORS   LePage,D.F., Altomare,D.A., Testa,J.R. and Walsh,K.
  TITLE     Molecular cloning and localization of the human GAX gene to 7p21
  JOURNAL   Genomics 24 (3), 535-540 (1994)
   PUBMED   7713505
REFERENCE   10 (bases 1 to 2383)
  AUTHORS   Reardon,W., McManus,S.P., Summers,D. and Winter,R.M.
  TITLE     Cytogenetic evidence that the Saethre-Chotzen gene maps to 7p21.2
  JOURNAL   Am. J. Med. Genet. 47 (5), 633-636 (1993)
   PUBMED   8266988
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA586635.1, BC017021.1 and
            BQ025060.1.
            This sequence is a reference standard in the RefSeqGene project.
            On Dec 30, 2005 this sequence version replaced gi:55956906.
            
            Summary: This gene encodes a member of a subfamily of
            non-clustered, diverged, antennapedia-like homeobox-containing
            genes. The encoded protein may play a role in the regulation of
            vertebrate limb myogenesis. Mutations in the related mouse protein
            may be associated with craniofacial and/or skeletal abnormalities,
            in addition to neurovascular dysfunction observed in Alzheimer's
            disease. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC017021.1, X82629.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           ERS025081, ERS025084 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-512               DA586635.1         1-512
            513-2049            BC017021.1         410-1946
            2050-2383           BQ025060.1         1-334               c
FEATURES             Location/Qualifiers
     source          1..2383
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p22.1-p21.3"
     gene            1..2383
                     /gene="MEOX2"
                     /gene_synonym="GAX; MOX2"
                     /note="mesenchyme homeobox 2"
                     /db_xref="GeneID:4223"
                     /db_xref="HGNC:7014"
                     /db_xref="MIM:600535"
     exon            1..798
                     /gene="MEOX2"
                     /gene_synonym="GAX; MOX2"
                     /inference="alignment:Splign:1.39.8"
     variation       243
                     /gene="MEOX2"
                     /gene_synonym="GAX; MOX2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1050290"
     misc_feature    246..248
                     /gene="MEOX2"
                     /gene_synonym="GAX; MOX2"
                     /note="upstream in-frame stop codon"
     CDS             282..1196
                     /gene="MEOX2"
                     /gene_synonym="GAX; MOX2"
                     /note="growth arrest-specific homeobox"
                     /codon_start=1
                     /product="homeobox protein MOX-2"
                     /protein_id="NP_005915.2"
                     /db_xref="GI:84105335"
                     /db_xref="CCDS:CCDS34605.1"
                     /db_xref="GeneID:4223"
                     /db_xref="HGNC:7014"
                     /db_xref="MIM:600535"
                     /translation="

MEHPLFGCLRSPHATAQGLHPFSQSSLALHGRSDHMSYPELSTSSSSCIIAGYPNEEGMFASQHHRGHHHHHHHHHHHHHQQQQHQALQTNWHLPQMSSPPSAARHSLCLQPDSGGPPELGSSPPVLCSNSSSLGSSTPTGAACAPGDYGRQALSPAEAEKRSGGKRKSDSSDSQEGNYKSEVNSKPRKERTAFTKEQIRELEAEFAHHNYLTRLRRYEIAVNLDLTERQVKVWFQNRRMKWKRVKGGQQGAAAREKELVNVKKGTLLPSELSGIGAATLQQTGDSIANEDSHDSDHSSEHAHL

"
     misc_feature    843..1019
                     /gene="MEOX2"
                     /gene_synonym="GAX; MOX2"
                     /note="Homeodomain;  DNA binding domains involved in the
                     transcriptional regulation of key eukaryotic developmental
                     processes; may bind to DNA as monomers or as homo- and/or
                     heterodimers, in a sequence-specific manner; Region:
                     homeodomain; cd00086"
                     /db_xref="CDD:28970"
     misc_feature    order(843..857,861..863,912..914,930..932,969..971,
                     975..980,987..992,996..1004,1008..1013)
                     /gene="MEOX2"
                     /gene_synonym="GAX; MOX2"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:28970"
     misc_feature    order(849..851,858..860,978..980,987..992,999..1001)
                     /gene="MEOX2"
                     /gene_synonym="GAX; MOX2"
                     /note="specific DNA base contacts [nucleotide binding];
                     other site"
                     /db_xref="CDD:28970"
     STS             537..687
                     /gene="MEOX2"
                     /gene_synonym="GAX; MOX2"
                     /standard_name="MEOX2"
                     /db_xref="UniSTS:503608"
     exon            799..971
                     /gene="MEOX2"
                     /gene_synonym="GAX; MOX2"
                     /inference="alignment:Splign:1.39.8"
     STS             818..878
                     /gene="MEOX2"
                     /gene_synonym="GAX; MOX2"
                     /standard_name="MEOX2"
                     /db_xref="UniSTS:23282"
     exon            972..2371
                     /gene="MEOX2"
                     /gene_synonym="GAX; MOX2"
                     /inference="alignment:Splign:1.39.8"
     STS             1374..1695
                     /gene="MEOX2"
                     /gene_synonym="GAX; MOX2"
                     /standard_name="G60276"
                     /db_xref="UniSTS:137381"
     STS             1376..1709
                     /gene="MEOX2"
                     /gene_synonym="GAX; MOX2"
                     /standard_name="SHGC-12960"
                     /db_xref="UniSTS:44537"
     variation       1438
                     /gene="MEOX2"
                     /gene_synonym="GAX; MOX2"
                     /replace="a"
                     /replace="c"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:17199"
     variation       1468
                     /gene="MEOX2"
                     /gene_synonym="GAX; MOX2"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:1131061"
     variation       1604
                     /gene="MEOX2"
                     /gene_synonym="GAX; MOX2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1050291"
     STS             2071..2204
                     /gene="MEOX2"
                     /gene_synonym="GAX; MOX2"
                     /standard_name="D7S2109E"
                     /db_xref="UniSTS:24755"
     polyA_signal    2349..2354
                     /gene="MEOX2"
                     /gene_synonym="GAX; MOX2"
     polyA_site      2371
                     /gene="MEOX2"
                     /gene_synonym="GAX; MOX2"
ORIGIN

gaaagcagttctctgggaccaccttcttttggcttcaacctctcccactcttgacatctgagtagctcagggaagctcttccaggtccgactgttcatatgtaaaggagactggccgctggggctcaggaccgggattatccgagctctgcagaagtgcaccgctattgctttgggaggttaaaaaaaaaatcacacggtttccagtgaaaaagtgacagagggtggtggcctttggaaccgccgtgaagtcttctgcctggaacccgaaacttgcatgctatggaacacccgctctttggctgcctgcgcagccctcacgccacggcgcaaggcttgcacccgttctcccaatcctctctcgccctccatggaagatctgaccatatgtcttaccccgagctctctacttcttcctcatcttgcataatcgcgggataccccaacgaagagggcatgtttgccagccagcatcacagggggcaccaccaccaccaccaccaccaccaccatcaccaccatcagcagcagcagcaccaggctctgcaaaccaactggcacctcccgcagatgtcttccccaccgagtgcggctcggcacagcctctgcctccagcccgactctggagggcccccagagttggggagcagcccgcccgtcctgtgctccaactcttccagcttgggctccagcaccccgactggggccgcgtgcgcgccgggggactacggccgccaggcactgtcacctgcggaggcggagaagcgaagcggcggcaagaggaaaagcgacagctcagactcccaggaaggaaattacaagtcagaagtcaacagcaaacccaggaaagaaaggacagcatttaccaaagagcaaatcagagaacttgaagcagaatttgcccatcataattatctcaccagactgaggcgatacgagatagcagtgaatctggatctcactgaaagacaggtgaaagtctggttccaaaacaggcggatgaagtggaagagggtaaagggtggacagcaaggagctgcggctcgggaaaaggaactggtgaatgtgaaaaagggaacacttctcccatcagagctgtcgggaattggtgcagccaccctccagcaaacaggggactctatagcaaatgaagacagtcacgacagtgaccacagctcagagcatgcgcacttatgatataaacagaggaccagctccattctcaggaaagaaatgttgtgatggcaagccttacccaaatatcgtttacacagagagatgactatggcagtgatgtttaatattattaaatccaggcatttcgaatctgtttttcatgatttatagagggtttacacaaagtgccacttattaaagagcttccacagtgaagatggagaaggtgaacttgctttgaatattccagatgtgtttggtcgtgcgtatggcagtgagcaggtatgtgtttgcttttgcttgcactgaaaattaaattgctatcaagagcaaactatgaacggttttttattcaagatgtctccagagtgaagatgccgaggatgaacttgcattgaacattccagatgtgtgagatcatgtgtattacagtgggcaggtatttgcttttgcttgcactgaaaattaaattgctatcaagaataaaccatgaaacattttatcctgaacagccacagtgcctgaattcactcaagtggataaaaagtgtattttaactctgtatatattacccttaagtcattttcctgtcttcactaatttagcaatgcattcatattagctgatgaaaataggcactcacaatgacaaccagagccagtttcttgtcttttttatacattttgtcatcccagagacaatcagtatgtgcttacctgtgttcaagtagagaaaaatacagtagagtctgataggacatattcttgtaccacagacaaaacaaatcttatgttgcatttactatcaactgctgctaatacgttattataaaacttacctagctcctgaattcttcctatcttatagcttaaaacaattaggatcataggcaaatcagttaccttgcagaaagagctttgtatgacagacattgtcttattttatttctgtaaaatattagctgtatgaatatgatttaattaacaagaaaacatttcttcctgattgacaacagtgttagacaaggtgcaaagcgaaactggttgctcaagttgatagaaaacaaaattctgaatatcttcaaattaaattcggtaaaaacacattattttttcatatgtgatgtattcatgcagaacaactatctttgtattttgtttttaaaatgtgtttaataaatgatcctttgtaaataaaaaaaaaaaaaa

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