LOCUS       NM_005604               4108 bp    mRNA    linear   PRI 17-JUN-2013
DEFINITION  Homo sapiens POU class 3 homeobox 2 (POU3F2), mRNA.
ACCESSION   NM_005604
VERSION     NM_005604.3  GI:380254475
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4108)
  AUTHORS   Sakaeda,M., Sato,H., Ishii,J., Miyata,C., Kamma,H.,
            Shishido-Hara,Y., Shimoyamada,H., Fujiwara,M., Endo,T., Tanaka,R.,
            Kondo,H., Goya,T., Aoki,I. and Yazawa,T.
  TITLE     Neural lineage-specific homeoprotein BRN2 is directly involved in
            TTF1 expression in small-cell lung cancer
  JOURNAL   Lab. Invest. 93 (4), 408-421 (2013)
   PUBMED   23358112
  REMARK    GeneRIF: TTF1 expression in small-cell lung cancer is a cell
            lineage-specific phenomenon that involves the developing neural
            cell-specific homeoprotein BRN2.
REFERENCE   2  (bases 1 to 4108)
  AUTHORS   Avery,C.L., Sitlani,C.M., Arking,D.E., Arnett,D.K., Bis,J.C.,
            Boerwinkle,E., Buckley,B.M., Ida Chen,Y.D., de Craen,A.J.,
            Eijgelsheim,M., Enquobahrie,D., Evans,D.S., Ford,I., Garcia,M.E.,
            Gudnason,V., Harris,T.B., Heckbert,S.R., Hochner,H., Hofman,A.,
            Hsueh,W.C., Isaacs,A., Jukema,J.W., Knekt,P., Kors,J.A.,
            Krijthe,B.P., Kristiansson,K., Laaksonen,M., Liu,Y., Li,X.,
            Macfarlane,P.W., Newton-Cheh,C., Nieminen,M.S., Oostra,B.A.,
            Peloso,G.M., Porthan,K., Rice,K., Rivadeneira,F.F., Rotter,J.I.,
            Salomaa,V., Sattar,N., Siscovick,D.S., Slagboom,P.E., Smith,A.V.,
            Sotoodehnia,N., Stott,D.J., Stricker,B.H., Sturmer,T., Trompet,S.,
            Uitterlinden,A.G., van Duijn,C., Westendorp,R.G., Witteman,J.C.,
            Whitsel,E.A. and Psaty,B.M.
  TITLE     Drug-gene interactions and the search for missing heritability: a
            cross-sectional pharmacogenomics study of the QT interval
  JOURNAL   Pharmacogenomics J. (2013) In press
   PUBMED   23459443
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   3  (bases 1 to 4108)
  AUTHORS   Ellmann,L., Joshi,M.B., Resink,T.J., Bosserhoff,A.K. and Kuphal,S.
  TITLE     BRN2 is a transcriptional repressor of CDH13 (T-cadherin) in
            melanoma cells
  JOURNAL   Lab. Invest. 92 (12), 1788-1800 (2012)
   PUBMED   23069940
  REMARK    GeneRIF: The present study investigated transcriptional regulation
            of CDH13 in melanoma. Found an inverse correlation between BRN2 and
            T-cadherin protein and transcript expression in melanoma.
REFERENCE   4  (bases 1 to 4108)
  AUTHORS   Comuzzie,A.G., Cole,S.A., Laston,S.L., Voruganti,V.S., Haack,K.,
            Gibbs,R.A. and Butte,N.F.
  TITLE     Novel genetic loci identified for the pathophysiology of childhood
            obesity in the Hispanic population
  JOURNAL   PLoS ONE 7 (12), E51954 (2012)
   PUBMED   23251661
REFERENCE   5  (bases 1 to 4108)
  AUTHORS   Eisen,T., Easty,D.J., Bennett,D.C. and Goding,C.R.
  TITLE     The POU domain transcription factor Brn-2: elevated expression in
            malignant melanoma and regulation of melanocyte-specific gene
            expression
  JOURNAL   Oncogene 11 (10), 2157-2164 (1995)
   PUBMED   7478537
REFERENCE   6  (bases 1 to 4108)
  AUTHORS   Atanasoski,S., Toldo,S.S., Malipiero,U., Schreiber,E., Fries,R. and
            Fontana,A.
  TITLE     Isolation of the human genomic brain-2/N-Oct 3 gene (POUF3) and
            assignment to chromosome 6q16
  JOURNAL   Genomics 26 (2), 272-280 (1995)
   PUBMED   7601453
REFERENCE   7  (bases 1 to 4108)
  AUTHORS   Schreiber,E., Tobler,A., Malipiero,U., Schaffner,W. and Fontana,A.
  TITLE     cDNA cloning of human N-Oct3, a nervous-system specific POU domain
            transcription factor binding to the octamer DNA motif
  JOURNAL   Nucleic Acids Res. 21 (2), 253-258 (1993)
   PUBMED   8441633
REFERENCE   8  (bases 1 to 4108)
  AUTHORS   Hara,Y., Rovescalli,A.C., Kim,Y. and Nirenberg,M.
  TITLE     Structure and evolution of four POU domain genes expressed in mouse
            brain
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 89 (8), 3280-3284 (1992)
   PUBMED   1565620
REFERENCE   9  (bases 1 to 4108)
  AUTHORS   Schreiber,E., Harshman,K., Kemler,I., Malipiero,U., Schaffner,W.
            and Fontana,A.
  TITLE     Astrocytes and glioblastoma cells express novel octamer-DNA binding
            proteins distinct from the ubiquitous Oct-1 and B cell type Oct-2
            proteins
  JOURNAL   Nucleic Acids Res. 18 (18), 5495-5503 (1990)
   PUBMED   2216722
REFERENCE   10 (bases 1 to 4108)
  AUTHORS   He,X., Treacy,M.N., Simmons,D.M., Ingraham,H.A., Swanson,L.W. and
            Rosenfeld,M.G.
  TITLE     Expression of a large family of POU-domain regulatory genes in
            mammalian brain development
  JOURNAL   Nature 340 (6228), 35-41 (1989)
   PUBMED   2739723
  REMARK    Erratum:[Nature 1989 Aug 24;340(6235):662]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA491157.1, BC051699.1 and
            AL022395.2.
            On Mar 14, 2012 this sequence version replaced gi:51702520.
            
            Summary: This gene encodes a member of the POU-III class of neural
            transcription factors. The encoded protein is involved in neuronal
            differentiation and enhances the activation of
            corticotropin-releasing hormone regulated genes. Overexpression of
            this protein is associated with an increase in the proliferation of
            melanoma cells. [provided by RefSeq, Mar 2012].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC051699.1 [ECO:0000345]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-31                DA491157.1         1-31
            32-358              BC051699.1         1-327
            359-359             AL022395.2         123085-123085       c
            360-788             BC051699.1         329-757
            789-797             AL022395.2         122647-122655       c
            798-1030            BC051699.1         767-999
            1031-1031           AL022395.2         122413-122413       c
            1032-1979           BC051699.1         1001-1948
            1980-3045           AL022395.2         120399-121464       c
            3046-4108           BC051699.1         3012-4074
FEATURES             Location/Qualifiers
     source          1..4108
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q16"
     gene            1..4108
                     /gene="POU3F2"
                     /gene_synonym="brn-2; BRN2; N-Oct3; oct-7; OCT7; OTF-7;
                     OTF7; POUF3"
                     /note="POU class 3 homeobox 2"
                     /db_xref="GeneID:5454"
                     /db_xref="HGNC:9215"
                     /db_xref="MIM:600494"
     exon            1..4087
                     /gene="POU3F2"
                     /gene_synonym="brn-2; BRN2; N-Oct3; oct-7; OCT7; OTF-7;
                     OTF7; POUF3"
                     /inference="alignment:Splign:1.39.8"
     variation       1
                     /gene="POU3F2"
                     /gene_synonym="brn-2; BRN2; N-Oct3; oct-7; OCT7; OTF-7;
                     OTF7; POUF3"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:186667950"
     misc_feature    6..8
                     /gene="POU3F2"
                     /gene_synonym="brn-2; BRN2; N-Oct3; oct-7; OCT7; OTF-7;
                     OTF7; POUF3"
                     /note="upstream in-frame stop codon"
     variation       157
                     /gene="POU3F2"
                     /gene_synonym="brn-2; BRN2; N-Oct3; oct-7; OCT7; OTF-7;
                     OTF7; POUF3"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:367580619"
     variation       159
                     /gene="POU3F2"
                     /gene_synonym="brn-2; BRN2; N-Oct3; oct-7; OCT7; OTF-7;
                     OTF7; POUF3"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:200105737"
     CDS             171..1502
                     /gene="POU3F2"
                     /gene_synonym="brn-2; BRN2; N-Oct3; oct-7; OCT7; OTF-7;
                     OTF7; POUF3"
                     /note="brain-2; octamer-binding protein 7; octamer-binding
                     transcription factor 7; brain-specific homeobox/POU domain
                     protein 2; nervous system-specific octamer-binding
                     transcription factor N-Oct-3"
                     /codon_start=1
                     /product="POU domain, class 3, transcription factor 2"
                     /protein_id="NP_005595.2"
                     /db_xref="GI:51702521"
                     /db_xref="CCDS:CCDS5040.1"
                     /db_xref="GeneID:5454"
                     /db_xref="HGNC:9215"
                     /db_xref="MIM:600494"
                     /translation="

MATAASNHYSLLTSSASIVHAEPPGGMQQGAGGYREAQSLVQGDYGALQSNGHPLSHAHQWITALSHGGGGGGGGGGGGGGGGGGGGGDGSPWSTSPLGQPDIKPSVVVQQGGRGDELHGPGALQQQHQQQQQQQQQQQQQQQQQQQQQRPPHLVHHAANHHPGPGAWRSAAAAAHLPPSMGASNGGLLYSQPSFTVNGMLGAGGQPAGLHHHGLRDAHDEPHHADHHPHPHSHPHQQPPPPPPPQGPPGHPGAHHDPHSDEDTPTSDDLEQFAKQFKQRRIKLGFTQADVGLALGTLYGNVFSQTTICRFEALQLSFKNMCKLKPLLNKWLEEADSSSGSPTSIDKIAAQGRKRKKRTSIEVSVKGALESHFLKCPKPSAQEITSLADSLQLEKEVVRVWFCNRRQKEKRMTPPGGTLPGAEDVYGGSRDTPPHHGVQTPVQ

"
     misc_feature    954..1178
                     /gene="POU3F2"
                     /gene_synonym="brn-2; BRN2; N-Oct3; oct-7; OCT7; OTF-7;
                     OTF7; POUF3"
                     /note="Found in Pit-Oct-Unc transcription factors; Region:
                     POU; smart00352"
                     /db_xref="CDD:197673"
     misc_feature    1191..1193
                     /gene="POU3F2"
                     /gene_synonym="brn-2; BRN2; N-Oct3; oct-7; OCT7; OTF-7;
                     OTF7; POUF3"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (P20265.4); phosphorylation site"
     misc_feature    1233..1406
                     /gene="POU3F2"
                     /gene_synonym="brn-2; BRN2; N-Oct3; oct-7; OCT7; OTF-7;
                     OTF7; POUF3"
                     /note="Homeodomain;  DNA binding domains involved in the
                     transcriptional regulation of key eukaryotic developmental
                     processes; may bind to DNA as monomers or as homo- and/or
                     heterodimers, in a sequence-specific manner; Region:
                     homeodomain; cd00086"
                     /db_xref="CDD:28970"
     misc_feature    order(1233..1247,1251..1253,1302..1304,1320..1322,
                     1359..1361,1365..1370,1377..1382,1386..1394,1398..1403)
                     /gene="POU3F2"
                     /gene_synonym="brn-2; BRN2; N-Oct3; oct-7; OCT7; OTF-7;
                     OTF7; POUF3"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:28970"
     misc_feature    order(1239..1241,1248..1250,1368..1370,1377..1382,
                     1389..1391)
                     /gene="POU3F2"
                     /gene_synonym="brn-2; BRN2; N-Oct3; oct-7; OCT7; OTF-7;
                     OTF7; POUF3"
                     /note="specific DNA base contacts [nucleotide binding];
                     other site"
                     /db_xref="CDD:28970"
     variation       180
                     /gene="POU3F2"
                     /gene_synonym="brn-2; BRN2; N-Oct3; oct-7; OCT7; OTF-7;
                     OTF7; POUF3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201781902"
     variation       223
                     /gene="POU3F2"
                     /gene_synonym="brn-2; BRN2; N-Oct3; oct-7; OCT7; OTF-7;
                     OTF7; POUF3"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:371461013"
     variation       314
                     /gene="POU3F2"
                     /gene_synonym="brn-2; BRN2; N-Oct3; oct-7; OCT7; OTF-7;
                     OTF7; POUF3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199873673"
     variation       359
                     /gene="POU3F2"
                     /gene_synonym="brn-2; BRN2; N-Oct3; oct-7; OCT7; OTF-7;
                     OTF7; POUF3"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:17854693"
     variation       572
                     /gene="POU3F2"
                     /gene_synonym="brn-2; BRN2; N-Oct3; oct-7; OCT7; OTF-7;
                     OTF7; POUF3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:367612148"
     variation       789
                     /gene="POU3F2"
                     /gene_synonym="brn-2; BRN2; N-Oct3; oct-7; OCT7; OTF-7;
                     OTF7; POUF3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:17854694"
     variation       797
                     /gene="POU3F2"
                     /gene_synonym="brn-2; BRN2; N-Oct3; oct-7; OCT7; OTF-7;
                     OTF7; POUF3"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:195860"
     variation       845
                     /gene="POU3F2"
                     /gene_synonym="brn-2; BRN2; N-Oct3; oct-7; OCT7; OTF-7;
                     OTF7; POUF3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:369383182"
     variation       885..893
                     /gene="POU3F2"
                     /gene_synonym="brn-2; BRN2; N-Oct3; oct-7; OCT7; OTF-7;
                     OTF7; POUF3"
                     /replace=""
                     /replace="ccgccgccc"
                     /db_xref="dbSNP:371685985"
     variation       942
                     /gene="POU3F2"
                     /gene_synonym="brn-2; BRN2; N-Oct3; oct-7; OCT7; OTF-7;
                     OTF7; POUF3"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:371856505"
     STS             1018..1252
                     /gene="POU3F2"
                     /gene_synonym="brn-2; BRN2; N-Oct3; oct-7; OCT7; OTF-7;
                     OTF7; POUF3"
                     /standard_name="POU3F2"
                     /db_xref="UniSTS:266184"
     variation       1031
                     /gene="POU3F2"
                     /gene_synonym="brn-2; BRN2; N-Oct3; oct-7; OCT7; OTF-7;
                     OTF7; POUF3"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:17854695"
     variation       1112
                     /gene="POU3F2"
                     /gene_synonym="brn-2; BRN2; N-Oct3; oct-7; OCT7; OTF-7;
                     OTF7; POUF3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:147437170"
     variation       1187
                     /gene="POU3F2"
                     /gene_synonym="brn-2; BRN2; N-Oct3; oct-7; OCT7; OTF-7;
                     OTF7; POUF3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200105843"
     variation       1226
                     /gene="POU3F2"
                     /gene_synonym="brn-2; BRN2; N-Oct3; oct-7; OCT7; OTF-7;
                     OTF7; POUF3"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:377608434"
     STS             1338..1957
                     /gene="POU3F2"
                     /gene_synonym="brn-2; BRN2; N-Oct3; oct-7; OCT7; OTF-7;
                     OTF7; POUF3"
                     /standard_name="POU3F2__v334"
                     /db_xref="UniSTS:277597"
     variation       1430
                     /gene="POU3F2"
                     /gene_synonym="brn-2; BRN2; N-Oct3; oct-7; OCT7; OTF-7;
                     OTF7; POUF3"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:369811680"
     variation       1437
                     /gene="POU3F2"
                     /gene_synonym="brn-2; BRN2; N-Oct3; oct-7; OCT7; OTF-7;
                     OTF7; POUF3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:373306906"
     variation       1481
                     /gene="POU3F2"
                     /gene_synonym="brn-2; BRN2; N-Oct3; oct-7; OCT7; OTF-7;
                     OTF7; POUF3"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:376966559"
     variation       1539
                     /gene="POU3F2"
                     /gene_synonym="brn-2; BRN2; N-Oct3; oct-7; OCT7; OTF-7;
                     OTF7; POUF3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:202224147"
     STS             1568..1827
                     /gene="POU3F2"
                     /gene_synonym="brn-2; BRN2; N-Oct3; oct-7; OCT7; OTF-7;
                     OTF7; POUF3"
                     /standard_name="WI-19206"
                     /db_xref="UniSTS:48794"
     variation       1641..1642
                     /gene="POU3F2"
                     /gene_synonym="brn-2; BRN2; N-Oct3; oct-7; OCT7; OTF-7;
                     OTF7; POUF3"
                     /replace=""
                     /replace="a"
                     /db_xref="dbSNP:199735616"
     variation       1641
                     /gene="POU3F2"
                     /gene_synonym="brn-2; BRN2; N-Oct3; oct-7; OCT7; OTF-7;
                     OTF7; POUF3"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:111620909"
     variation       1641
                     /gene="POU3F2"
                     /gene_synonym="brn-2; BRN2; N-Oct3; oct-7; OCT7; OTF-7;
                     OTF7; POUF3"
                     /replace=""
                     /replace="c"
                     /db_xref="dbSNP:71545770"
     STS             1657..1759
                     /gene="POU3F2"
                     /gene_synonym="brn-2; BRN2; N-Oct3; oct-7; OCT7; OTF-7;
                     OTF7; POUF3"
                     /standard_name="D6S2053"
                     /db_xref="UniSTS:1498"
     variation       1665
                     /gene="POU3F2"
                     /gene_synonym="brn-2; BRN2; N-Oct3; oct-7; OCT7; OTF-7;
                     OTF7; POUF3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:375953848"
     variation       1730
                     /gene="POU3F2"
                     /gene_synonym="brn-2; BRN2; N-Oct3; oct-7; OCT7; OTF-7;
                     OTF7; POUF3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:192443961"
     variation       1808
                     /gene="POU3F2"
                     /gene_synonym="brn-2; BRN2; N-Oct3; oct-7; OCT7; OTF-7;
                     OTF7; POUF3"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:183346230"
     variation       1867..1868
                     /gene="POU3F2"
                     /gene_synonym="brn-2; BRN2; N-Oct3; oct-7; OCT7; OTF-7;
                     OTF7; POUF3"
                     /replace=""
                     /replace="a"
                     /db_xref="dbSNP:34400185"
     variation       1912
                     /gene="POU3F2"
                     /gene_synonym="brn-2; BRN2; N-Oct3; oct-7; OCT7; OTF-7;
                     OTF7; POUF3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:79339339"
     variation       1953
                     /gene="POU3F2"
                     /gene_synonym="brn-2; BRN2; N-Oct3; oct-7; OCT7; OTF-7;
                     OTF7; POUF3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:3823036"
     variation       1961..1962
                     /gene="POU3F2"
                     /gene_synonym="brn-2; BRN2; N-Oct3; oct-7; OCT7; OTF-7;
                     OTF7; POUF3"
                     /replace=""
                     /replace="c"
                     /db_xref="dbSNP:34587175"
     variation       2187
                     /gene="POU3F2"
                     /gene_synonym="brn-2; BRN2; N-Oct3; oct-7; OCT7; OTF-7;
                     OTF7; POUF3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:112324835"
     variation       2202
                     /gene="POU3F2"
                     /gene_synonym="brn-2; BRN2; N-Oct3; oct-7; OCT7; OTF-7;
                     OTF7; POUF3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:187647254"
     variation       2405
                     /gene="POU3F2"
                     /gene_synonym="brn-2; BRN2; N-Oct3; oct-7; OCT7; OTF-7;
                     OTF7; POUF3"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:33999841"
     variation       2408
                     /gene="POU3F2"
                     /gene_synonym="brn-2; BRN2; N-Oct3; oct-7; OCT7; OTF-7;
                     OTF7; POUF3"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:377168368"
     variation       2418
                     /gene="POU3F2"
                     /gene_synonym="brn-2; BRN2; N-Oct3; oct-7; OCT7; OTF-7;
                     OTF7; POUF3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:138126958"
     variation       2452
                     /gene="POU3F2"
                     /gene_synonym="brn-2; BRN2; N-Oct3; oct-7; OCT7; OTF-7;
                     OTF7; POUF3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:9398940"
     STS             2482..2592
                     /gene="POU3F2"
                     /gene_synonym="brn-2; BRN2; N-Oct3; oct-7; OCT7; OTF-7;
                     OTF7; POUF3"
                     /standard_name="D6S1231E"
                     /db_xref="UniSTS:151103"
     STS             2551..2665
                     /gene="POU3F2"
                     /gene_synonym="brn-2; BRN2; N-Oct3; oct-7; OCT7; OTF-7;
                     OTF7; POUF3"
                     /standard_name="RH12297"
                     /db_xref="UniSTS:44898"
     variation       2640
                     /gene="POU3F2"
                     /gene_synonym="brn-2; BRN2; N-Oct3; oct-7; OCT7; OTF-7;
                     OTF7; POUF3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:12665323"
     variation       2649
                     /gene="POU3F2"
                     /gene_synonym="brn-2; BRN2; N-Oct3; oct-7; OCT7; OTF-7;
                     OTF7; POUF3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:77971107"
     variation       2696
                     /gene="POU3F2"
                     /gene_synonym="brn-2; BRN2; N-Oct3; oct-7; OCT7; OTF-7;
                     OTF7; POUF3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:191299683"
     variation       2725..2726
                     /gene="POU3F2"
                     /gene_synonym="brn-2; BRN2; N-Oct3; oct-7; OCT7; OTF-7;
                     OTF7; POUF3"
                     /replace=""
                     /replace="t"
                     /db_xref="dbSNP:200874161"
     variation       2734..2735
                     /gene="POU3F2"
                     /gene_synonym="brn-2; BRN2; N-Oct3; oct-7; OCT7; OTF-7;
                     OTF7; POUF3"
                     /replace=""
                     /replace="t"
                     /db_xref="dbSNP:57487121"
     variation       2940
                     /gene="POU3F2"
                     /gene_synonym="brn-2; BRN2; N-Oct3; oct-7; OCT7; OTF-7;
                     OTF7; POUF3"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:150077448"
     variation       2980
                     /gene="POU3F2"
                     /gene_synonym="brn-2; BRN2; N-Oct3; oct-7; OCT7; OTF-7;
                     OTF7; POUF3"
                     /replace=""
                     /replace="a"
                     /db_xref="dbSNP:5878562"
     variation       3007
                     /gene="POU3F2"
                     /gene_synonym="brn-2; BRN2; N-Oct3; oct-7; OCT7; OTF-7;
                     OTF7; POUF3"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:138384155"
     variation       3049
                     /gene="POU3F2"
                     /gene_synonym="brn-2; BRN2; N-Oct3; oct-7; OCT7; OTF-7;
                     OTF7; POUF3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:79872709"
     variation       3057
                     /gene="POU3F2"
                     /gene_synonym="brn-2; BRN2; N-Oct3; oct-7; OCT7; OTF-7;
                     OTF7; POUF3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:66683016"
     variation       3107
                     /gene="POU3F2"
                     /gene_synonym="brn-2; BRN2; N-Oct3; oct-7; OCT7; OTF-7;
                     OTF7; POUF3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:62423591"
     variation       3142
                     /gene="POU3F2"
                     /gene_synonym="brn-2; BRN2; N-Oct3; oct-7; OCT7; OTF-7;
                     OTF7; POUF3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:144504012"
     variation       3191
                     /gene="POU3F2"
                     /gene_synonym="brn-2; BRN2; N-Oct3; oct-7; OCT7; OTF-7;
                     OTF7; POUF3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:113027329"
     variation       3214
                     /gene="POU3F2"
                     /gene_synonym="brn-2; BRN2; N-Oct3; oct-7; OCT7; OTF-7;
                     OTF7; POUF3"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:182079068"
     variation       3236
                     /gene="POU3F2"
                     /gene_synonym="brn-2; BRN2; N-Oct3; oct-7; OCT7; OTF-7;
                     OTF7; POUF3"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:187177491"
     variation       3370
                     /gene="POU3F2"
                     /gene_synonym="brn-2; BRN2; N-Oct3; oct-7; OCT7; OTF-7;
                     OTF7; POUF3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:192631653"
     variation       3404..3405
                     /gene="POU3F2"
                     /gene_synonym="brn-2; BRN2; N-Oct3; oct-7; OCT7; OTF-7;
                     OTF7; POUF3"
                     /replace=""
                     /replace="c"
                     /db_xref="dbSNP:34463125"
     variation       3496
                     /gene="POU3F2"
                     /gene_synonym="brn-2; BRN2; N-Oct3; oct-7; OCT7; OTF-7;
                     OTF7; POUF3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:73501598"
     variation       3518
                     /gene="POU3F2"
                     /gene_synonym="brn-2; BRN2; N-Oct3; oct-7; OCT7; OTF-7;
                     OTF7; POUF3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:375972837"
     variation       3554
                     /gene="POU3F2"
                     /gene_synonym="brn-2; BRN2; N-Oct3; oct-7; OCT7; OTF-7;
                     OTF7; POUF3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:185412225"
     variation       3587
                     /gene="POU3F2"
                     /gene_synonym="brn-2; BRN2; N-Oct3; oct-7; OCT7; OTF-7;
                     OTF7; POUF3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:190040379"
     variation       3795..3796
                     /gene="POU3F2"
                     /gene_synonym="brn-2; BRN2; N-Oct3; oct-7; OCT7; OTF-7;
                     OTF7; POUF3"
                     /replace=""
                     /replace="t"
                     /db_xref="dbSNP:66634163"
     variation       3823
                     /gene="POU3F2"
                     /gene_synonym="brn-2; BRN2; N-Oct3; oct-7; OCT7; OTF-7;
                     OTF7; POUF3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:193052910"
     STS             3831..4086
                     /gene="POU3F2"
                     /gene_synonym="brn-2; BRN2; N-Oct3; oct-7; OCT7; OTF-7;
                     OTF7; POUF3"
                     /standard_name="WI-22176"
                     /db_xref="UniSTS:21304"
     variation       4082
                     /gene="POU3F2"
                     /gene_synonym="brn-2; BRN2; N-Oct3; oct-7; OCT7; OTF-7;
                     OTF7; POUF3"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:77120481"
     polyA_site      4087
                     /gene="POU3F2"
                     /gene_synonym="brn-2; BRN2; N-Oct3; oct-7; OCT7; OTF-7;
                     OTF7; POUF3"
ORIGIN      

agtaatagcaggagcagcaacagaaggcgtcggagcgggcgtcggagctgcccgctgtgggagagagaggagacagaaagagcgagcgaggagagggagcccgaggcgaaaaagtaactgtcaaatgcgcggctcctttaaccggagcgctcagtccggctccgagagtcatggcgaccgcagcgtctaaccactacagcctgctcacctccagcgcctccatcgtgcacgccgagccgcccggcggcatgcagcagggcgcggggggctaccgcgaagcgcagagcctggtgcagggcgactacggcgctctgcagagcaacggacacccgctcagccacgctcaccagtggatcaccgcgctgtcccacggcggcggcggcgggggcggtggcggcggcggggggggcgggggcggcggcgggggcggcggcgacggctccccgtggtccaccagccccctgggccagccggacatcaagccctcggtggtggtgcagcagggcggccgcggagacgagctgcacgggccaggcgccctgcagcagcagcatcagcagcagcaacagcaacagcagcagcaacagcagcaacagcagcagcagcagcagcaacagcggccgccgcatctggtgcaccacgccgctaaccaccacccgggacccggggcatggcggagcgcggcggctgcagcgcacctcccaccctccatgggagcgtccaacggcggcttgctctactcgcagcccagcttcacggtgaacggcatgctgggcgccggcgggcagccggccggtctgcaccaccacggcctgcgggacgcgcacgacgagccacaccatgccgaccaccacccgcacccgcactcgcacccacaccagcagccgccgcccccgccgcccccgcagggtccgcctggccacccaggcgcgcaccacgacccgcactcggacgaggacacgccgacctcggacgacctggagcagttcgccaagcagttcaagcagcggcggatcaaactgggatttacccaagcggacgtggggctggctctgggcaccctgtatggcaacgtgttctcgcagaccaccatctgcaggtttgaggccctgcagctgagcttcaagaacatgtgcaagctgaagcctttgttgaacaagtggttggaggaggcggactcgtcctcgggcagccccacgagcatagacaagatcgcagcgcaagggcgcaagcggaaaaagcggacctccatcgaggtgagcgtcaagggggctctggagagccatttcctcaaatgccccaagccctcggcccaggagatcacctccctcgcggacagcttacagctggagaaggaggtggtgagagtttggttttgtaacaggagacagaaagagaaaaggatgacccctcccggagggactctgccgggcgccgaggatgtgtacggggggagtagggacactccaccacaccacggggtgcagacgcccgtccagtgaactcgagctgggggaggggcagagcgcggggctccccctccccttcggtccttggccctttcccggccctcttgttccctctctaacttctgattgttcttttatttttaattattatttccccgtcccttaaaaagacaaaaaaaataaggcaaaaggaaagcaactaagacactggactatcctttaaaggtagcaggtgtaatgatgtgttttgacctttgcaggcgagtaaccaggcaatggagtggagtgtctcctggagagagtgaggagagtgtgtgatagctagaaagagagagagacagagagatggcaagcactgagataaatacctggcaaaactaaataaattaccaaaaaggaaaaaaaatccaccaaaccatgataaacacaaaatgcagcttcctgatgcttagagttggcacatgctgctgtgtttatttattgtggattcccatcaggaaagaggaaaaaatacacatgttctttcatataggcaaaatttaaccacataaatttgcactgcaagaaaattgaagtttacgtgaacaaattcatgagcatattttctctttctccccaccgttaatttgggagttgccgttttgggggattttgttttgctttgctttattcatcggagagagttgaagccagctcttggccactctccatttctaatgttcttgtgttgccccttcttcgtactgtttgtgaactttggttaccttcacattccccttacgagggtgtaacatctatttgttcctcttaccaaagcaaaaggattggcttcatacaaaatagacaattctctgatttcaggaaatgtgcatggtctacccgctttatcgaaggcaagaatccggtttggaatataaaaataagcattggttgttcttaccagccacaaagtaaacttcattttcaggcagtgtttctgggggaggttatggagggaagaaaaaagaaaaatcgatagtgagtgactgattgcttcattttatcaggcgggcccattgtgaaagagctcaggggaaatgtggaggttaaatatatttccagagttgtccagcagaaagaaagtggcactttgaagagaactagggaagtacatatcttcagatatccctatatagttctctaccttcagttttagtaacaattatgaagaattatttgtgctgacagcagcagttaaactttgtttctctaatagctttttttttacataaaaaaagacccaggaacttaatagtgtatgcataagactgtgttttttagcacacagatacccacagcatacactgacgatctccacgcagtagacaggttttgtcttcactagctcatttgtttatcaagtcatatttagggtcccacaccctcttttcctgtaatttattgcagaatacaccactttgacttggacagctttctgccccctctttcactaaggaaggcaaatgaagtgaaaaaaaaaaatgccattttcaatccttcctttctcccctttgttaatagttttaagtgaatttttgaccttatcttaatggaaaacggttaactccaaacacaaaagactctactggaaagtgtaggtgaaaaaacttgtaactgtattgaaaataaataccattaaactgtgatcagttaaaatttaaaagaaaaatcagcacaaaagggcgctaaaagggaaaacactttttattaatcttaaaagtttgggggtttttttccagttaggtattagataaatttttattttaaaaaatgaaagtctcactaccataaaattatggttcagcatcagattagcattgcactcagtagtctttaaggttttaggaaatatgctttatattgtcttttcaaacacctgtgattgtttcattttccatgtttttgcaagataaatggtgacttataatgggcatatttatttgcctgtatttcatttcccccaatgaatgtcacaaggagatgggcacggagctgcttcgggtgcatcacgctgctcgttcctgaggtatgggaactggcctttagtgaagctatccagagcagggcaaatagccactggtaaagggaggaaatgaatttccagatacttattaccaagtaggtaaggtcagaagctggagttcagagaatgtgtctacagcttctctgactcttataggtttactaagatgaaagttaccactgaaccttaccactatgtatatatgtttaatatctgtcttttgaaatgcagaaatagtttaaatgtttctttgtctatttttctttttttttaatgctacccagggaaatattttcatatcatttttaagtggcctgcctcaatgtatatttatttcttttgaaacaaaaaggttctggaaactgtttttctgtagctttaaatgaataggtgagcaaaatctatatgggatgtaatttttttgttcagtctcttaaaaaatactttgttttggtacatttggttgtgcttgtggggaaaataaaaacgcagagatccttatatatttatgttaaagtaatattttattatctacataaaacagaaatgcacaataaaaaaaaaaaaaaaaaaaaaa

//

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:5454 -> Molecular function: GO:0001105 [RNA polymerase II transcription coactivator activity] evidence: IEA
            GeneID:5454 -> Molecular function: GO:0003700 [sequence-specific DNA binding transcription factor activity] evidence: IEA
            GeneID:5454 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
            GeneID:5454 -> Molecular function: GO:0042802 [identical protein binding] evidence: IPI
            GeneID:5454 -> Molecular function: GO:0043565 [sequence-specific DNA binding] evidence: IEA
            GeneID:5454 -> Biological process: GO:0008284 [positive regulation of cell proliferation] evidence: IDA
            GeneID:5454 -> Biological process: GO:0008544 [epidermis development] evidence: IEA
            GeneID:5454 -> Biological process: GO:0014002 [astrocyte development] evidence: IEA
            GeneID:5454 -> Biological process: GO:0021799 [cerebral cortex radially oriented cell migration] evidence: IEA
            GeneID:5454 -> Biological process: GO:0021869 [forebrain ventricular zone progenitor cell division] evidence: IEA
            GeneID:5454 -> Biological process: GO:0021979 [hypothalamus cell differentiation] evidence: IEA
            GeneID:5454 -> Biological process: GO:0021985 [neurohypophysis development] evidence: IEA
            GeneID:5454 -> Biological process: GO:0022011 [myelination in peripheral nervous system] evidence: IEA
            GeneID:5454 -> Biological process: GO:0030182 [neuron differentiation] evidence: IEA
            GeneID:5454 -> Biological process: GO:0040018 [positive regulation of multicellular organism growth] evidence: IEA
            GeneID:5454 -> Biological process: GO:0050770 [regulation of axonogenesis] evidence: IEA
            GeneID:5454 -> Biological process: GO:0071310 [cellular response to organic substance] evidence: IEA
            GeneID:5454 -> Cellular component: GO:0005667 [transcription factor complex] evidence: IEA