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2024-03-29 11:02:25, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_005602               2761 bp    mRNA    linear   PRI 17-APR-2013
DEFINITION  Homo sapiens claudin 11 (CLDN11), transcript variant 1, mRNA.
ACCESSION   NM_005602
VERSION     NM_005602.5  GI:195947370
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2761)
  AUTHORS   Chiba,K., Yamaguchi,K., Ando,M., Miyake,H. and Fujisawa,M.
  TITLE     Expression pattern of testicular claudin-11 in infertile men
  JOURNAL   Urology 80 (5), 1161 (2012)
   PUBMED   22951003
  REMARK    GeneRIF: disorganization of claudin-11 expression in Sertoli cells
            might be one of the factors involved in the impairment of
            spermatogenesis.
REFERENCE   2  (bases 1 to 2761)
  AUTHORS   Katsushima,K., Shinjo,K., Natsume,A., Ohka,F., Fujii,M., Osada,H.,
            Sekido,Y. and Kondo,Y.
  TITLE     Contribution of microRNA-1275 to Claudin11 protein suppression via
            a polycomb-mediated silencing mechanism in human glioma stem-like
            cells
  JOURNAL   J. Biol. Chem. 287 (33), 27396-27406 (2012)
   PUBMED   22736761
  REMARK    GeneRIF: Treatment with 3-deazaneplanocin A, an inhibitor of H3K27
            methyltransferase, attenuated CLDN11 induction by serum stimulation
            in parallel with sustained miR-1275 expression
REFERENCE   3  (bases 1 to 2761)
  AUTHORS   Kote-Jarai,Z., Olama,A.A., Giles,G.G., Severi,G., Schleutker,J.,
            Weischer,M., Campa,D., Riboli,E., Key,T., Gronberg,H., Hunter,D.J.,
            Kraft,P., Thun,M.J., Ingles,S., Chanock,S., Albanes,D., Hayes,R.B.,
            Neal,D.E., Hamdy,F.C., Donovan,J.L., Pharoah,P., Schumacher,F.,
            Henderson,B.E., Stanford,J.L., Ostrander,E.A., Sorensen,K.D.,
            Dork,T., Andriole,G., Dickinson,J.L., Cybulski,C., Lubinski,J.,
            Spurdle,A., Clements,J.A., Chambers,S., Aitken,J., Gardiner,R.A.,
            Thibodeau,S.N., Schaid,D., John,E.M., Maier,C., Vogel,W.,
            Cooney,K.A., Park,J.Y., Cannon-Albright,L., Brenner,H., Habuchi,T.,
            Zhang,H.W., Lu,Y.J., Kaneva,R., Muir,K., Benlloch,S.,
            Leongamornlert,D.A., Saunders,E.J., Tymrakiewicz,M., Mahmud,N.,
            Guy,M., O'Brien,L.T., Wilkinson,R.A., Hall,A.L., Sawyer,E.J.,
            Dadaev,T., Morrison,J., Dearnaley,D.P., Horwich,A., Huddart,R.A.,
            Khoo,V.S., Parker,C.C., Van As,N., Woodhouse,C.J., Thompson,A.,
            Christmas,T., Ogden,C., Cooper,C.S., Lophatonanon,A., Southey,M.C.,
            Hopper,J.L., English,D.R., Wahlfors,T., Tammela,T.L., Klarskov,P.,
            Nordestgaard,B.G., Roder,M.A., Tybjaerg-Hansen,A., Bojesen,S.E.,
            Travis,R., Canzian,F., Kaaks,R., Wiklund,F., Aly,M., Lindstrom,S.,
            Diver,W.R., Gapstur,S., Stern,M.C., Corral,R., Virtamo,J., Cox,A.,
            Haiman,C.A., Le Marchand,L., Fitzgerald,L., Kolb,S., Kwon,E.M.,
            Karyadi,D.M., Orntoft,T.F., Borre,M., Meyer,A., Serth,J.,
            Yeager,M., Berndt,S.I., Marthick,J.R., Patterson,B.,
            Wokolorczyk,D., Batra,J., Lose,F., McDonnell,S.K., Joshi,A.D.,
            Shahabi,A., Rinckleb,A.E., Ray,A., Sellers,T.A., Lin,H.Y.,
            Stephenson,R.A., Farnham,J., Muller,H., Rothenbacher,D.,
            Tsuchiya,N., Narita,S., Cao,G.W., Slavov,C., Mitev,V., Easton,D.F.
            and Eeles,R.A.
  CONSRTM   UK Genetic Prostate Cancer Study Collaborators/British Association
            of Urological Surgeons' Section of Oncology; UK ProtecT Study
            Collaborators, The Australian Prostate Cancer BioResource;
            PRACTICAL Consortium
  TITLE     Seven prostate cancer susceptibility loci identified by a
            multi-stage genome-wide association study
  JOURNAL   Nat. Genet. 43 (8), 785-791 (2011)
   PUBMED   21743467
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2761)
  AUTHORS   Awsare,N.S., Martin,T.A., Haynes,M.D., Matthews,P.N. and Jiang,W.G.
  TITLE     Claudin-11 decreases the invasiveness of bladder cancer cells
  JOURNAL   Oncol. Rep. 25 (6), 1503-1509 (2011)
   PUBMED   21468549
  REMARK    GeneRIF: claudin-11 may have a role in preventing cancer
            progression and may serve as a therapeutic target in reducing
            metastasis
REFERENCE   5  (bases 1 to 2761)
  AUTHORS   Nah,W.H., Lee,J.E., Park,H.J., Park,N.C. and Gye,M.C.
  TITLE     Claudin-11 expression increased in spermatogenic defect in human
            testes
  JOURNAL   Fertil. Steril. 95 (1), 385-388 (2011)
   PUBMED   20850723
  REMARK    GeneRIF: late spermatogenic wave may negatively regulate claudin-11
            gene activation and the subcellular localization of claudin-11 in
            Sertoli cells, thus altering the blood testis barrier in the human
            testis
REFERENCE   6  (bases 1 to 2761)
  AUTHORS   Kniesel,U. and Wolburg,H.
  TITLE     Tight junctions of the blood-brain barrier
  JOURNAL   Cell. Mol. Neurobiol. 20 (1), 57-76 (2000)
   PUBMED   10690502
  REMARK    Review article
REFERENCE   7  (bases 1 to 2761)
  AUTHORS   Gow,A., Southwood,C.M., Li,J.S., Pariali,M., Riordan,G.P.,
            Brodie,S.E., Danias,J., Bronstein,J.M., Kachar,B. and
            Lazzarini,R.A.
  TITLE     CNS myelin and sertoli cell tight junction strands are absent in
            Osp/claudin-11 null mice
  JOURNAL   Cell 99 (6), 649-659 (1999)
   PUBMED   10612400
REFERENCE   8  (bases 1 to 2761)
  AUTHORS   Shafit-Zagardo,B., Kress,Y., Zhao,M.L. and Lee,S.C.
  TITLE     A novel microtubule-associated protein-2 expressed in
            oligodendrocytes in multiple sclerosis lesions
  JOURNAL   J. Neurochem. 73 (6), 2531-2537 (1999)
   PUBMED   10582615
REFERENCE   9  (bases 1 to 2761)
  AUTHORS   Bronstein,J.M., Popper,P., Micevych,P.E. and Farber,D.B.
  TITLE     Isolation and characterization of a novel oligodendrocyte-specific
            protein
  JOURNAL   Neurology 47 (3), 772-778 (1996)
   PUBMED   8797478
REFERENCE   10 (bases 1 to 2761)
  AUTHORS   Bronstein,J.M., Kozak,C.A., Chen,X.N., Wu,S., Danciger,M.,
            Korenberg,J.R. and Farber,D.B.
  TITLE     Chromosomal localization of murine and human
            oligodendrocyte-specific protein genes
  JOURNAL   Genomics 34 (2), 255-257 (1996)
   PUBMED   8661061
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC328248.1, BC013577.1 and
            AC008041.5.
            On Aug 7, 2008 this sequence version replaced gi:33598917.
            
            Summary: This gene encodes a member of the claudin family. Claudins
            are integral membrane proteins and components of tight junction
            strands. Tight junction strands serve as a physical barrier to
            prevent solutes and water from passing freely through the
            paracellular space between epithelial or endothelial cell sheets,
            and also play critical roles in maintaining cell polarity and
            signal transductions. The protein encoded by this gene is a major
            component of central nervous system (CNS) myelin and plays an
            important role in regulating proliferation and migration of
            oligodendrocytes. Mouse studies showed that the gene deficiency
            results in deafness and loss of the Sertoli cell epithelial
            phenotype in the testis. This protein is a tight junction protein
            at the human blood-testis barrier (BTB), and the BTB disruption is
            related to a dysfunction of this gene. Alternatively spliced
            transcript variants encoding different isoforms have been
            identified.[provided by RefSeq, Aug 2010].
            
            Transcript Variant: This variant (1) is the longer transcript and
            encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC013577.1, BI824787.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           ERS025081, ERS025082 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                DC328248.1         1-12
            13-1093             BC013577.1         1-1081
            1094-2761           AC008041.5         17342-19009
FEATURES             Location/Qualifiers
     source          1..2761
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q26.2-q26.3"
     gene            1..2761
                     /gene="CLDN11"
                     /gene_synonym="OSP; OTM"
                     /note="claudin 11"
                     /db_xref="GeneID:5010"
                     /db_xref="HGNC:8514"
                     /db_xref="HPRD:03207"
                     /db_xref="MIM:601326"
     exon            1..428
                     /gene="CLDN11"
                     /gene_synonym="OSP; OTM"
                     /inference="alignment:Splign:1.39.8"
     variation       73
                     /gene="CLDN11"
                     /gene_synonym="OSP; OTM"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:370409883"
     misc_feature    167..169
                     /gene="CLDN11"
                     /gene_synonym="OSP; OTM"
                     /note="upstream in-frame stop codon"
     variation       186
                     /gene="CLDN11"
                     /gene_synonym="OSP; OTM"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:8192636"
     CDS             203..826
                     /gene="CLDN11"
                     /gene_synonym="OSP; OTM"
                     /note="isoform 1 is encoded by transcript variant 1;
                     oligodendrocyte transmembrane protein; claudin-11;
                     oligodendrocyte-specific protein"
                     /codon_start=1
                     /product="claudin-11 isoform 1"
                     /protein_id="NP_005593.2"
                     /db_xref="GI:10938016"
                     /db_xref="CCDS:CCDS3213.1"
                     /db_xref="GeneID:5010"
                     /db_xref="HGNC:8514"
                     /db_xref="HPRD:03207"
                     /db_xref="MIM:601326"
                     /translation="
MVATCLQVVGFVTSFVGWIGVIVTTSTNDWVVTCGYTIPTCRKLDELGSKGLWADCVMATGLYHCKPLVDILILPGYVQACRALMIAASVLGLPAILLLLTVLPCIRMGQEPGVAKYRRAQLAGVLLILLALCALVATIWFPVCAHRETTIVSFGYSLYAGWIGAVLCLVGGCVILCCAGDAQAFGENRFYYTAGSSSPTHAKSAHV
"
     misc_feature    206..268
                     /gene="CLDN11"
                     /gene_synonym="OSP; OTM"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (O75508.2);
                     transmembrane region"
     misc_feature    218..>547
                     /gene="CLDN11"
                     /gene_synonym="OSP; OTM"
                     /note="PMP-22/EMP/MP20/Claudin family; Region:
                     PMP22_Claudin; cl15797"
                     /db_xref="CDD:210197"
     misc_feature    449..511
                     /gene="CLDN11"
                     /gene_synonym="OSP; OTM"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (O75508.2);
                     transmembrane region"
     misc_feature    569..631
                     /gene="CLDN11"
                     /gene_synonym="OSP; OTM"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (O75508.2);
                     transmembrane region"
     misc_feature    674..736
                     /gene="CLDN11"
                     /gene_synonym="OSP; OTM"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (O75508.2);
                     transmembrane region"
     variation       268
                     /gene="CLDN11"
                     /gene_synonym="OSP; OTM"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:145075208"
     variation       320
                     /gene="CLDN11"
                     /gene_synonym="OSP; OTM"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:201720518"
     variation       331
                     /gene="CLDN11"
                     /gene_synonym="OSP; OTM"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:376285070"
     variation       340
                     /gene="CLDN11"
                     /gene_synonym="OSP; OTM"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:376171338"
     variation       418
                     /gene="CLDN11"
                     /gene_synonym="OSP; OTM"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:370405833"
     exon            429..593
                     /gene="CLDN11"
                     /gene_synonym="OSP; OTM"
                     /inference="alignment:Splign:1.39.8"
     variation       433
                     /gene="CLDN11"
                     /gene_synonym="OSP; OTM"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:367974397"
     variation       450
                     /gene="CLDN11"
                     /gene_synonym="OSP; OTM"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:148297542"
     variation       484
                     /gene="CLDN11"
                     /gene_synonym="OSP; OTM"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:141421186"
     variation       538
                     /gene="CLDN11"
                     /gene_synonym="OSP; OTM"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:150789369"
     variation       590
                     /gene="CLDN11"
                     /gene_synonym="OSP; OTM"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:371649486"
     exon            594..2761
                     /gene="CLDN11"
                     /gene_synonym="OSP; OTM"
                     /inference="alignment:Splign:1.39.8"
     variation       601
                     /gene="CLDN11"
                     /gene_synonym="OSP; OTM"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:138100932"
     variation       602
                     /gene="CLDN11"
                     /gene_synonym="OSP; OTM"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:143763226"
     variation       624..625
                     /gene="CLDN11"
                     /gene_synonym="OSP; OTM"
                     /replace=""
                     /replace="a"
                     /db_xref="dbSNP:34124448"
     variation       642
                     /gene="CLDN11"
                     /gene_synonym="OSP; OTM"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:146493095"
     variation       656
                     /gene="CLDN11"
                     /gene_synonym="OSP; OTM"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:377105856"
     variation       715
                     /gene="CLDN11"
                     /gene_synonym="OSP; OTM"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:375051671"
     variation       784
                     /gene="CLDN11"
                     /gene_synonym="OSP; OTM"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:369096350"
     variation       788
                     /gene="CLDN11"
                     /gene_synonym="OSP; OTM"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:372554090"
     variation       797
                     /gene="CLDN11"
                     /gene_synonym="OSP; OTM"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:144303681"
     variation       807
                     /gene="CLDN11"
                     /gene_synonym="OSP; OTM"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:375624085"
     variation       808
                     /gene="CLDN11"
                     /gene_synonym="OSP; OTM"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:140975891"
     variation       820
                     /gene="CLDN11"
                     /gene_synonym="OSP; OTM"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200665065"
     variation       837
                     /gene="CLDN11"
                     /gene_synonym="OSP; OTM"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:369963006"
     variation       838
                     /gene="CLDN11"
                     /gene_synonym="OSP; OTM"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:374008151"
     variation       850
                     /gene="CLDN11"
                     /gene_synonym="OSP; OTM"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:373002112"
     variation       916
                     /gene="CLDN11"
                     /gene_synonym="OSP; OTM"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:192477349"
     variation       967..968
                     /gene="CLDN11"
                     /gene_synonym="OSP; OTM"
                     /replace=""
                     /replace="ttt"
                     /db_xref="dbSNP:10620799"
     variation       1060
                     /gene="CLDN11"
                     /gene_synonym="OSP; OTM"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:60306951"
     variation       1094
                     /gene="CLDN11"
                     /gene_synonym="OSP; OTM"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:6770844"
     variation       1178
                     /gene="CLDN11"
                     /gene_synonym="OSP; OTM"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:369372951"
     variation       1193
                     /gene="CLDN11"
                     /gene_synonym="OSP; OTM"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:374137538"
     variation       1201
                     /gene="CLDN11"
                     /gene_synonym="OSP; OTM"
                     /replace=""
                     /replace="t"
                     /replace="ttt"
                     /db_xref="dbSNP:11322219"
     variation       1447
                     /gene="CLDN11"
                     /gene_synonym="OSP; OTM"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:144763446"
     variation       1506
                     /gene="CLDN11"
                     /gene_synonym="OSP; OTM"
                     /replace="a"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:75747180"
     variation       1603
                     /gene="CLDN11"
                     /gene_synonym="OSP; OTM"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:71306669"
     variation       1616
                     /gene="CLDN11"
                     /gene_synonym="OSP; OTM"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:146584959"
     variation       1632
                     /gene="CLDN11"
                     /gene_synonym="OSP; OTM"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:77614151"
     variation       1740
                     /gene="CLDN11"
                     /gene_synonym="OSP; OTM"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:116573207"
     variation       1764
                     /gene="CLDN11"
                     /gene_synonym="OSP; OTM"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:114923460"
     variation       1790
                     /gene="CLDN11"
                     /gene_synonym="OSP; OTM"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:184479005"
     variation       1830
                     /gene="CLDN11"
                     /gene_synonym="OSP; OTM"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:76935838"
     variation       1956
                     /gene="CLDN11"
                     /gene_synonym="OSP; OTM"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:141295233"
     variation       1973
                     /gene="CLDN11"
                     /gene_synonym="OSP; OTM"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:13973"
     STS             2024..2151
                     /gene="CLDN11"
                     /gene_synonym="OSP; OTM"
                     /standard_name="SHGC-77525"
                     /db_xref="UniSTS:21761"
     variation       2027
                     /gene="CLDN11"
                     /gene_synonym="OSP; OTM"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:143257986"
     variation       2057
                     /gene="CLDN11"
                     /gene_synonym="OSP; OTM"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:79247818"
     polyA_signal    2144..2149
                     /gene="CLDN11"
                     /gene_synonym="OSP; OTM"
     variation       2156
                     /gene="CLDN11"
                     /gene_synonym="OSP; OTM"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:188703062"
     polyA_site      2169
                     /gene="CLDN11"
                     /gene_synonym="OSP; OTM"
     variation       2223
                     /gene="CLDN11"
                     /gene_synonym="OSP; OTM"
                     /replace=""
                     /replace="t"
                     /db_xref="dbSNP:199859109"
     polyA_signal    2302..2307
                     /gene="CLDN11"
                     /gene_synonym="OSP; OTM"
     polyA_site      2320
                     /gene="CLDN11"
                     /gene_synonym="OSP; OTM"
     variation       2325
                     /gene="CLDN11"
                     /gene_synonym="OSP; OTM"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:192810780"
     variation       2326
                     /gene="CLDN11"
                     /gene_synonym="OSP; OTM"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:74578076"
     variation       2327
                     /gene="CLDN11"
                     /gene_synonym="OSP; OTM"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:184973915"
     variation       2340
                     /gene="CLDN11"
                     /gene_synonym="OSP; OTM"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:189444465"
     variation       2413
                     /gene="CLDN11"
                     /gene_synonym="OSP; OTM"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:77575392"
     variation       2418
                     /gene="CLDN11"
                     /gene_synonym="OSP; OTM"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:141576986"
     variation       2469
                     /gene="CLDN11"
                     /gene_synonym="OSP; OTM"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:191573902"
     variation       2490
                     /gene="CLDN11"
                     /gene_synonym="OSP; OTM"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:150475064"
     variation       2654
                     /gene="CLDN11"
                     /gene_synonym="OSP; OTM"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:138487700"
ORIGIN      
agcagcgctgctgtccccgccgtgcgcccttcgccgctgagctcgcagcctccggcgcccacctccacctccagtgtcccgcctcgggccgtcgccctccagcggctcgcgagcgtgggagacgtacctgggcaggcactgtccagcccaggcccaggcacagccgtgaggggcgaggcacggggacatcctggcggccaccatggtggccacgtgcctgcaggtggtgggcttcgtcacgagcttcgtgggctggatcggggtcatcgtgaccacctccaccaatgactgggtggtgacctgcggctacaccatccccacctgccgcaagctggatgagctgggctccaaggggctgtgggccgactgcgtcatggccacggggctgtaccactgcaagcccctggtggacatcctcatcctgccgggctacgtgcaggcctgccgcgccctgatgattgctgcctcggtcctgggtctgccggccattttactgctgctgactgttcttccctgcatccggatgggccaggagcccggtgtggctaagtacaggcgggcccagctggctggtgttttgctcattctgctggctctctgcgcccttgttgccaccatctggttccctgtgtgcgcccaccgtgagaccaccatcgtgagctttggctactccctgtatgcaggctggattggtgctgtgctgtgcctcgtgggtggctgtgtcatcctctgctgcgctggagatgcccaggcctttggtgaaaaccgtttctactacactgcgggctctagctccccgactcatgcgaagagtgcccacgtataagagggctgcccggctgcccacagaggtgctgtagatgctgggcccagggccctaggtttgctcgtcacagtgtggggaagcccattcctctgccaggctctaaagccaaaggtctagaaaagcatcctgtctggcattttgtagtcttaacttctccccatttcccccatcttttggttgccttaaaagaaatctctagctcagataatgcccagacatttttttcccttggtgttgcccctattagctcttttcttgggcattcttttgctgtttattaaaaatatattatatatattttgtttctttaaatttcaaatgttttgcaaacatcactgagttaggtgggggtggggaagagaaatacaagatacttttttttttttttttttttttttttttttaaatagggcctcactctgttgctcaggctggagtgcggtggtgtgatctcggctcatgtagcctcaacctccccggctcaagtgatcctcctgcctcagcctcccaagtagctgggactacaggcgttcactactacacccagctaatttttaagttttttatagagatgagggctccctatgttgcccaggttggtctcgaactcctggactcaaagtatcctcccgcctcggcctcccaaagtgttgggattataggagtgagccaccacaccggccaagatgcttttcaaactgatacagatgacaatgggagcctcataaagatggcttttgtttcttcccttcaaggtcatttacttgtacgagacagaaaaagatagcattggggacatgggatgggggagggagggcaatagtggaacgaactttccatgggaaactttcccttttgtaagttgagggccaggggtagggatattttttagtttgtgattttacatttatctgtacatactttttcaagattgatcatttttataaccatggttttcctgaaatcctcaattcatcaatatgaaggaaatgaaccacatagactttatgcaataaataacagtgcaagtgagtataactctaactgatgttccacaaaacatttttgatttcaggtttgtatgatgtagtttttaatcgtacattttcatatgcttcaaactaacacatttttaaagctttcccccacttttctctctatttgtattgttagccatcttgaagtgatgttgtttaacataaattgtactgttgaatttggctttacgggtgtaaacactgatggtatatcagtatctgagaccccaaactctccaaatactgatggtgcattttattcttgaagtgaaatctgtgcaataaaataacagactgtctgcaaaactggccttcaatcttctgttgtatccagaggtatcattattgatttaaaaaaatctcattaatctctactggtaatttatagggaatctgatcagtgattcaagaacaagtaattctgcattgccttgaataattaaaaagttatattttattcacggtattgcagtggtaatttgtggtcatgaaagcataacctcagtgctctctaggtttcttaagtggggtgactttatggcatctttaatcatcgatcaatgggcagcaatcagaaacaaagttctcagcattatgcagttaatgtccttcatctacttctaacacttagtaaaggaattgattggctaggtataaaaagagaattaacgaaacctattttattggatctttaagtaataatatctaaatacatttcgttcaaacatacatatgtagctgtttggacattttggacaaagacacattgagttgatttttatttgtttttctgttccagaaacttcatcaagttacgggcctggtctaagaaaacacattgcaatctattttggcagacttctttcaaataaaatactaatttcattagctgatagta
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:5010 -> Molecular function: GO:0005198 [structural molecule activity] evidence: IEA
            GeneID:5010 -> Molecular function: GO:0042802 [identical protein binding] evidence: ISS
            GeneID:5010 -> Biological process: GO:0007283 [spermatogenesis] evidence: IEA
            GeneID:5010 -> Biological process: GO:0008366 [axon ensheathment] evidence: IEA
            GeneID:5010 -> Biological process: GO:0016338 [calcium-independent cell-cell adhesion] evidence: ISS
            GeneID:5010 -> Cellular component: GO:0005886 [plasma membrane] evidence: IEA
            GeneID:5010 -> Cellular component: GO:0005923 [tight junction] evidence: ISS
            GeneID:5010 -> Cellular component: GO:0016021 [integral to membrane] evidence: IEA

by @meso_cacase at DBCLS
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