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2024-03-29 02:26:59, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_005312               6121 bp    mRNA    linear   PRI 17-APR-2013
DEFINITION  Homo sapiens Rap guanine nucleotide exchange factor (GEF) 1
            (RAPGEF1), transcript variant 1, mRNA.
ACCESSION   NM_005312
VERSION     NM_005312.2  GI:38373674
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6121)
  AUTHORS   Gutierrez-Herrero,S., Maia,V., Gutierrez-Berzal,J., Calzada,N.,
            Sanz,M., Gonzalez-Manchon,C., Pericacho,M., Ortiz-Rivero,S.,
            Gonzalez-Porras,J.R., Arechederra,M., Porras,A. and Guerrero,C.
  TITLE     C3G transgenic mouse models with specific expression in platelets
            reveal a new role for C3G in platelet clotting through its GEF
            activity
  JOURNAL   Biochim. Biophys. Acta 1823 (8), 1366-1377 (2012)
   PUBMED   22659131
  REMARK    GeneRIF: C3G plays an important role in platelet clotting through a
            mechanism involving its GEF activity and suggest that it might be
            also involved in neutrophil development.
REFERENCE   2  (bases 1 to 6121)
  AUTHORS   He,Y., Kapoor,A., Cook,S., Liu,S., Xiang,Y., Rao,C.V., Kenis,P.J.
            and Wang,F.
  TITLE     The non-receptor tyrosine kinase Lyn controls neutrophil adhesion
            by recruiting the CrkL-C3G complex and activating Rap1 at the
            leading edge
  JOURNAL   J. Cell. Sci. 124 (PT 13), 2153-2164 (2011)
   PUBMED   21628423
  REMARK    GeneRIF: Lyn controls spatial activation of Rap1 by recruiting the
            CrkL-C3G protein complex to the leading edge
REFERENCE   3  (bases 1 to 6121)
  AUTHORS   Samuelsson,J., Alonso,S., Ruiz-Larroya,T., Cheung,T.H., Wong,Y.F.
            and Perucho,M.
  TITLE     Frequent somatic demethylation of RAPGEF1/C3G intronic sequences in
            gastrointestinal and gynecological cancer
  JOURNAL   Int. J. Oncol. 38 (6), 1575-1577 (2011)
   PUBMED   21399874
  REMARK    GeneRIF: found somatic demethylation of a relaxed-criterion CpG
            island (CGI-B) located in the first intron of RAPGEF1 in 40% of
            colon cancers and 8% of gastric cancers relative to their matching
            normal tissues that were always methylated
REFERENCE   4  (bases 1 to 6121)
  AUTHORS   Dayma,K. and Radha,V.
  TITLE     Cytoskeletal remodeling by C3G to induce neurite-like extensions
            and inhibit motility in highly invasive breast carcinoma cells
  JOURNAL   Biochim. Biophys. Acta 1813 (3), 456-465 (2011)
   PUBMED   21223981
  REMARK    GeneRIF: C3G overexpression induces neurite-like extensions in
            MDA-MB-231 and BT549 breast carcinoma cells and not in a variety of
            other cancer cell lines examined.
REFERENCE   5  (bases 1 to 6121)
  AUTHORS   Mitra,A., Kalayarasan,S., Gupta,V. and Radha,V.
  TITLE     TC-PTP dephosphorylates the guanine nucleotide exchange factor C3G
            (RapGEF1) and negatively regulates differentiation of human
            neuroblastoma cells
  JOURNAL   PLoS ONE 6 (8), E23681 (2011)
   PUBMED   21876762
  REMARK    GeneRIF: The possibility of cellular phospho-C3G (pC3G) being a
            substrate of the intracellular T-cell protein tyrosine phosphatase
            TC-PTP (PTPN2) using the human neuroblastoma cell line, was
            studied.
REFERENCE   6  (bases 1 to 6121)
  AUTHORS   Smit,L., van der Horst,G. and Borst,J.
  TITLE     Sos, Vav, and C3G participate in B cell receptor-induced signaling
            pathways and differentially associate with Shc-Grb2, Crk, and Crk-L
            adaptors
  JOURNAL   J. Biol. Chem. 271 (15), 8564-8569 (1996)
   PUBMED   8621483
REFERENCE   7  (bases 1 to 6121)
  AUTHORS   Gotoh,T., Hattori,S., Nakamura,S., Kitayama,H., Noda,M., Takai,Y.,
            Kaibuchi,K., Matsui,H., Hatase,O., Takahashi,H. et al.
  TITLE     Identification of Rap1 as a target for the Crk SH3 domain-binding
            guanine nucleotide-releasing factor C3G
  JOURNAL   Mol. Cell. Biol. 15 (12), 6746-6753 (1995)
   PUBMED   8524240
REFERENCE   8  (bases 1 to 6121)
  AUTHORS   Knudsen,B.S., Feller,S.M. and Hanafusa,H.
  TITLE     Four proline-rich sequences of the guanine-nucleotide exchange
            factor C3G bind with unique specificity to the first Src homology 3
            domain of Crk
  JOURNAL   J. Biol. Chem. 269 (52), 32781-32787 (1994)
   PUBMED   7806500
REFERENCE   9  (bases 1 to 6121)
  AUTHORS   Takai,S., Tanaka,M., Sugimura,H., Yamada,K., Naito,Y., Kino,I. and
            Matsuda,M.
  TITLE     Mapping of the human C3G gene coding a guanine nucleotide releasing
            protein for Ras family to 9q34.3 by fluorescence in situ
            hybridization
  JOURNAL   Hum. Genet. 94 (5), 549-550 (1994)
   PUBMED   7959692
REFERENCE   10 (bases 1 to 6121)
  AUTHORS   Tanaka,S., Morishita,T., Hashimoto,Y., Hattori,S., Nakamura,S.,
            Shibuya,M., Matuoka,K., Takenawa,T., Kurata,T., Nagashima,K. et al.
  TITLE     C3G, a guanine nucleotide-releasing protein expressed ubiquitously,
            binds to the Src homology 3 domains of CRK and GRB2/ASH proteins
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 91 (8), 3443-3447 (1994)
   PUBMED   7512734
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from D21239.1, BC041710.1,
            BQ054243.1, BQ772947.1 and AJ420417.1.
            On Nov 18, 2003 this sequence version replaced gi:4885356.
            
            Summary: This gene encodes a human guanine nucleotide exchange
            factor. It transduces signals from CRK by binding the SH3 domain of
            CRK, and activating several members of the Ras family of GTPases.
            This signaling cascade that may be involved in apoptosis,
            integrin-mediated signal transduction, and cell transformation.
            Several alternatively spliced transcript variants of this gene have
            been described, but the full-length nature of some variants has not
            been determined. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) differs in the 5' UTR compared
            to variant 2. This results in a shorter isoform (a) with a distinct
            N-terminus, compared to isoform b.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D21239.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           ERS025081, ERS025082 [ECO:0000350]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-988               D21239.1           1-988
            989-4271            BC041710.1         951-4233
            4272-4695           BQ054243.1         218-641
            4696-5566           BC041710.1         4658-5528
            5567-5915           BQ772947.1         194-542             c
            5916-6121           AJ420417.1         1546-1751
FEATURES             Location/Qualifiers
     source          1..6121
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q34.3"
     gene            1..6121
                     /gene="RAPGEF1"
                     /gene_synonym="C3G; GRF2"
                     /note="Rap guanine nucleotide exchange factor (GEF) 1"
                     /db_xref="GeneID:2889"
                     /db_xref="HGNC:4568"
                     /db_xref="HPRD:02627"
                     /db_xref="MIM:600303"
     misc_feature    92..94
                     /gene="RAPGEF1"
                     /gene_synonym="C3G; GRF2"
                     /note="upstream in-frame stop codon"
     CDS             131..3364
                     /gene="RAPGEF1"
                     /gene_synonym="C3G; GRF2"
                     /note="isoform a is encoded by transcript variant 1;
                     guanine nucleotide-releasing factor 2 (specific for crk
                     proto-oncogene); rap guanine nucleotide exchange factor 1;
                     CRK SH3-binding GNRP"
                     /codon_start=1
                     /product="rap guanine nucleotide exchange factor 1 isoform
                     a"
                     /protein_id="NP_005303.2"
                     /db_xref="GI:38373675"
                     /db_xref="CCDS:CCDS48047.1"
                     /db_xref="GeneID:2889"
                     /db_xref="HGNC:4568"
                     /db_xref="HPRD:02627"
                     /db_xref="MIM:600303"
                     /translation="
MDTDSQRSHLSSFTMKLMDKFHSPKIKRTPSKKGKPAEVSVKIPEKPVNKEATDRFLPEGYPLPLDLEQQAVEFMSTSAVASRSQRQKNLSWLEEKEKEVVSALRYFKTIVDKMAIDKKVLEMLPGSASKVLEAILPLVQNDPRIQHSSALSSCYSRVYQSLANLIRWSDQVMLEGVNSEDKEMVTTVKGVIKAVLDGVKELVRLTIEKQGRPSPTSPVKPSSPASKPDGPAELPLTDREVEILNKTTGMSQSTELLPDATDEEVAPPKPPLPGIRVVDNSPPPALPPKKRQSAPSPTRVAVVAPMSRATSGSSLPVGINRQDFDVDCYAQRRLSGGSHSYGGESPRLSPCSSIGKLSKSDEQLSSLDRDSGQCSRNTSCETLDHYDPDYEFLQQDLSNADQIPQQTAWNLSPLPESLGESGSPFLGPPFQLPLGGHPQPDGPLAPGQQTDTPPALPEKKRRSAASQTADGSGCRVSYERHPSQYDNISGEDLQSTAPIPSVPYAPFAAILPFQHGGSSAPVEFVGDFTAPESTGDPEKPPPLPEKKNKHMLAYMQLLEDYSEPQPSMFYQTPQNEHIYQQKNKLLMEVYGFSDSFSGVDSVQELAPPPALPPKQRQLEPPAGKDGHPRDPSAVSGVPGKDSRDGSERAPKSPDALESAQSEEEVDELSLIDHNEIMSRLTLKQEGDDGPDVRGGSGDILLVHATETDRKDLVLYCEAFLTTYRTFISPEELIKKLQYRYEKFSPFADTFKKRVSKNTFFVLVRVVDELCLVELTEEILKLLMELVFRLVCNGELSLARVLRKNILDKVDQKKLLRCATSSQPLAARGVAARPGTLHDFHSHEIAEQLTLLDAELFYKIEIPEVLLWAKEQNEEKSPNLTQFTEHFNNMSYWVRSIIMLQEKAQDRERLLLKFIKIMKHLRKLNNFNSYLAILSALDSAPIRRLEWQKQTSEGLAEYCTLIDSSSSFRAYRAALSEVEPPCIPYLGLILQDLTFVHLGNPDYIDGKVNFSKRWQQFNILDSMRCFQQAHYDMRRNDDIINFFNDFSDHLAEEALWELSLKIKPRNITRRKTDREEKT
"
     misc_feature    971..1006
                     /gene="RAPGEF1"
                     /gene_synonym="C3G; GRF2"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q13905.3);
                     Region: SH3-binding"
     misc_feature    1007..1009
                     /gene="RAPGEF1"
                     /gene_synonym="C3G; GRF2"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (Q13905.3); phosphorylation site"
     misc_feature    1022..1024
                     /gene="RAPGEF1"
                     /gene_synonym="C3G; GRF2"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     misc_feature    1058..1060
                     /gene="RAPGEF1"
                     /gene_synonym="C3G; GRF2"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     misc_feature    1061..1063
                     /gene="RAPGEF1"
                     /gene_synonym="C3G; GRF2"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     misc_feature    1070..1072
                     /gene="RAPGEF1"
                     /gene_synonym="C3G; GRF2"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     misc_feature    1208..1210
                     /gene="RAPGEF1"
                     /gene_synonym="C3G; GRF2"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (Q13905.3); phosphorylation site"
     misc_feature    1208..1210
                     /gene="RAPGEF1"
                     /gene_synonym="C3G; GRF2"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     misc_feature    1481..1516
                     /gene="RAPGEF1"
                     /gene_synonym="C3G; GRF2"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q13905.3);
                     Region: SH3-binding"
     misc_feature    1640..1642
                     /gene="RAPGEF1"
                     /gene_synonym="C3G; GRF2"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphotyrosine, by HCK; propagated from
                     UniProtKB/Swiss-Prot (Q13905.3); phosphorylation site"
     misc_feature    1640..1642
                     /gene="RAPGEF1"
                     /gene_synonym="C3G; GRF2"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
                     /db_xref="HPRD:00796"
     misc_feature    1742..1777
                     /gene="RAPGEF1"
                     /gene_synonym="C3G; GRF2"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q13905.3);
                     Region: SH3-binding"
     misc_feature    1946..1981
                     /gene="RAPGEF1"
                     /gene_synonym="C3G; GRF2"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q13905.3);
                     Region: SH3-binding"
     misc_feature    2216..2560
                     /gene="RAPGEF1"
                     /gene_synonym="C3G; GRF2"
                     /note="Guanine nucleotide exchange factor for Ras-like
                     GTPases; N-terminal domain (RasGef_N), also called REM
                     domain (Ras exchanger motif). This domain is common in
                     nucleotide exchange factors for Ras-like small GTPases and
                     is typically found immediately...; Region: REM; cd06224"
                     /db_xref="CDD:100121"
     misc_feature    order(2249..2251,2384..2386,2396..2401,2408..2410,
                     2417..2422,2528..2533,2540..2542)
                     /gene="RAPGEF1"
                     /gene_synonym="C3G; GRF2"
                     /note="GTPase interaction site [polypeptide binding];
                     other site"
                     /db_xref="CDD:100121"
     misc_feature    2636..3310
                     /gene="RAPGEF1"
                     /gene_synonym="C3G; GRF2"
                     /note="Guanine nucleotide exchange factor for Ras-like
                     small GTPases. Small GTP-binding proteins of the Ras
                     superfamily function as molecular switches in fundamental
                     events such as signal transduction, cytoskeleton dynamics
                     and intracellular trafficking; Region: RasGEF; cd00155"
                     /db_xref="CDD:29070"
     misc_feature    order(2726..2734,2765..2770,2774..2782,2786..2791,
                     2798..2803,2810..2812,2909..2911,2918..2923,2927..2935,
                     2939..2950,2954..2959,3002..3004,3011..3013,3026..3034,
                     3041..3043,3080..3088,3095..3103,3107..3115,3119..3130,
                     3170..3172,3182..3184,3284..3286,3293..3298)
                     /gene="RAPGEF1"
                     /gene_synonym="C3G; GRF2"
                     /note="Ras interaction site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:29070"
     variation       989
                     /gene="RAPGEF1"
                     /gene_synonym="C3G; GRF2"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:1128780"
     variation       1194
                     /gene="RAPGEF1"
                     /gene_synonym="C3G; GRF2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1062978"
     STS             3594..3782
                     /gene="RAPGEF1"
                     /gene_synonym="C3G; GRF2"
                     /standard_name="STS-D21239"
                     /db_xref="UniSTS:75875"
     variation       4272
                     /gene="RAPGEF1"
                     /gene_synonym="C3G; GRF2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:3739497"
     variation       5567
                     /gene="RAPGEF1"
                     /gene_synonym="C3G; GRF2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:943851"
     STS             5796..5992
                     /gene="RAPGEF1"
                     /gene_synonym="C3G; GRF2"
                     /standard_name="A002Q14"
                     /db_xref="UniSTS:54080"
     STS             5838..6042
                     /gene="RAPGEF1"
                     /gene_synonym="C3G; GRF2"
                     /standard_name="RH11721"
                     /db_xref="UniSTS:8448"
     variation       5878
                     /gene="RAPGEF1"
                     /gene_synonym="C3G; GRF2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:6879"
     STS             5904..6042
                     /gene="RAPGEF1"
                     /gene_synonym="C3G; GRF2"
                     /standard_name="D9S2054"
                     /db_xref="UniSTS:8447"
     polyA_signal    6061..6066
                     /gene="RAPGEF1"
                     /gene_synonym="C3G; GRF2"
     polyA_site      6091
                     /gene="RAPGEF1"
                     /gene_synonym="C3G; GRF2"
                     /experiment="experimental evidence, no additional details
                     recorded"
ORIGIN      
gaattcccttttctgggcaccgccttctgctagggggttgtagatgaaagtgcctgctcccagagaagcttgtctaacctagcacagtttctaagctacccaggctgccagaccgagcgaccgtgctgccatggacacagactctcagcgttctcatctctcttccttcaccatgaagctgatggacaaattccactcacccaaaatcaagagaacgccatcaaagaagggaaaaccagctgaggtgtccgtaaagattccagagaagcctgtgaacaaagaggcaacagacagatttctaccagagggctaccctctccccttggatctggagcagcaggcagtagaatttatgtccaccagtgctgtggcttccaggtctcaaaggcagaagaacctgagctggctggaggagaaagagaaggaagttgtcagtgccctgcgctactttaagaccattgtggacaaaatggcaattgataagaaggtactggagatgcttccagggtcagccagcaaggtgctggaggccatcttacccctggtgcagaacgatcctcgaattcagcacagctcagccctctcttcctgctatagccgagtgtaccaaagcctcgccaacctcattcgctggtctgaccaagtgatgctggaaggcgtgaactcagaagacaaggagatggtgacgactgtgaagggggtcatcaaggctgtgctggatggagtgaaggagctggtcaggctcaccatcgagaagcagggacgtccgtctccgacgagccccgtgaagcccagttcccctgccagcaagcctgatggcccagcagagctccccctgacagaccgcgaggtagagatcctaaacaagacgactgggatgtcacagtcaactgagctcctcccagatgccacggatgaagaggtcgcgccccccaagcctcctctgcctggcattcgggtggttgataatagtcctccaccagcattgccacccaagaaaagacagtcggcgccgtcccctacccgagtggctgtggtggcccccatgagccgagccaccagtggctccagtttgcctgttggaatcaataggcaggattttgatgttgactgttacgcacagaggcgactgtcaggaggcagccactcatatggtggagagtcgccccgcctctccccctgcagcagcataggcaagctcagcaagtcagacgagcagctgtcctctctggacagggacagtgggcagtgctcccggaacacaagctgtgaaacactagaccactatgatcccgactatgaattcctccagcaagacctctctaacgcagaccagatacctcagcagacggcctggaaccttagcccgttgccagagtctttgggggagtctgggtctccatttcttggccctcctttccagctgcctcttggcggccatccccagccagacggacctctggccccagggcagcagacagatacgccacctgctctccccgagaagaagcgcaggagcgcagcctcccagacggcggacggctctggctgcagggtgtcctacgagcggcatccctcgcagtatgacaacatctctggggaggacctgcagagcacagccccgatcccatccgtcccctacgcgccctttgctgctattctgccctttcagcatggaggttcctcagcccctgtcgaatttgtgggtgattttactgctcctgagtcaaccggtgacccagaaaaaccacctcctctaccagagaagaaaaacaaacacatgctggcctacatgcagttgctggaggactactcggagccgcagccctctatgttctaccagacgccacagaacgagcacatctaccagcagaagaacaagctcctcatggaggtatacggcttcagcgactccttcagtggggtggactccgtgcaggagctggccccgccgcccgccctaccccccaagcagcggcagctggagccaccggctgggaaagacggacatcccagagatccctcagcggtcagcggcgtccctgggaaggacagcagagacggcagtgagagggccccaaagtcaccagatgctctggagtcggctcagtcggaggaggaagtggacgagctgtccctcattgaccacaacgaaattatgtccaggctgacgctcaagcaggagggtgatgacgggccggacgtccgcggaggatctggggacatcttactggtccatgctactgagactgacaggaaagatttggtgttgtactgcgaggcattcctgaccacctacaggaccttcatctccccagaggagctcatcaagaagctgcagtacagatatgagaaattctctccctttgccgacacattcaagaagcgcgtcagcaagaacacgttcttcgtgctggtacgggtggtggatgagctctgcctggtggagttgacagaagagatcctgaagctgctgatggaactggtcttccgcctggtgtgcaatggggagctgagcctggcccgtgtgctccggaagaacatcctggacaaggtggaccagaagaagctactcaggtgtgccacctccagccagcccctggcagcccggggggtagcagccaggccggggaccttgcacgactttcacagccatgagatagcggagcagctaacgctgctggatgctgagctcttctataaaatagagattcctgaggttttgctttgggcaaaagagcagaatgaggagaagagccccaacttgacccagttcacggagcacttcaacaacatgtcctactgggtccggtccataatcatgttacaggaaaaggcccaggacagggaacggctgctcttgaagttcatcaagatcatgaagcacttgcggaagctgaataacttcaactcctacttggccatcctctctgccctggactcggcgcccatccgcaggctggagtggcagaagcagacttcagagggcctggccgagtactgcacactgatcgacagctcgtcctccttccgagcctaccgggccgccctctcggaggtggaaccgccgtgcatcccgtacctggggctgatcctgcaggacctgaccttcgttcacctgggaaacccagactacatcgacgggaaagtgaacttctccaagcggtggcagcagttcaacatcctcgacagcatgcgctgcttccagcaggcgcactatgacatgcggaggaacgacgacattataaacttcttcaatgacttcagtgaccacctggctgaggaggccctatgggaactgtctctgaaaattaaacccaggaacataacaaggagaaaaacagaccgggaagagaagacctaggagcagacgccgggatccaggagaatgctcgaggggcgcagagggcagctcccagaccggagaggaccttggacctgttaggcgcatggcaggagtcccggcctcggagccatgaggctggccagccctcagcggggccgggcgggagctggagcctgccagccgcttcctgcctccttcctctgtgggagcagacccgtgggcctcagggcagccagcaggcaggtcttgttgccaatttacaaaccggtggttttctggtttggttttgttttctgcttttacttccatctctcccctcttgaccttccacccactcccctccagggagagagcagcagagacctcatcagcagaccaaggaagtggtgggtgctccccctccctaagctccagggtccctgaatcttctgaaatctcaaatgagtggaggcctcctggggtggcctgtcctgcaggggccctggaatgggggcaagcagctgggtgggcagaatgcagagtagactcgggggaggatcctttcactttccgcttccccttctgatgcatggaggatggtgtgagcttttcagcaggcccggaaaggtacgcaggtgacgccttagcagccccgcagctggtgctctgccccgcggtactggcgccatcagggcctcccttgcccgcctgagagcagcagcagtctctgtcatcccgtcgccccttaccccccaccccaggccactgggcccctcccacaccacctggggagctgagaagaggaggctggagtaagggaggacttgatcatccaagaaatactttttattgctgggagtcttctgaacctcaccaaactgaggccagagctgagctcctgggggagttaattcagaggggagaggccagcacctccctcctccatcgctcgctgtgtgccttaaactccatctcatgtccctccccatcccctggctttccctccctccttgccccatcctgggccagccagcagggctcctcctctggctcttcagacctttcagccagtgctgtcagtgcccctgggagggaagggcatccctgaggcacccgaatggtccctcagggtgcagggaggcagaagcctggccacagaggagcctcctaaggcagcagctgcagcaagcgcaccctctccccactctccccacgccagagcggcttccagagcagatgctgtttccatcctcctcgtcaaaaccattctcgctgctgagcttgacaatctgggcaaggcttgtggggcgcttgacaaacagaatctgccctgtgccgcctggttccgtggcctccagcatgagcctgcaggcagggcgctgcgggaacccagttgtgctgccccagcccatgcctccgggtctgctgtgcatgaatgagtgctcacttgtcccgggtttaggacgtggtcaagtgaacagcagggtctaactgtgcttacttagcccagttcaaacagaacaaaggaaaaatatagaaagcaacatctgttgatcatttaggtttttttttaaaccaccatgtcactttgagtccttcatgggtttttgaacagcatttatcaagaagaaaatgtgggctttttcccctctcccgtgttttgtttgtcctgtagatagagggaggaaagccgtgcagtggcaggcgggaccccctctggtggcgggaccccctcttgcggtggtcttgcggggccagccgggacctgtcactttattatttaaggagtgtgtgtgtagagtcgctggcttattaacagtattgtgtgtgggttgggtttttagtttgttccttctttttgaagtcccttcatttcaatccttgactctctctccccttcccttgcccagctctgttgaatgctgctgtgcgcgtgtgagggccgctctgcacacagggcccttgggttgtgtgaactgaaattctccctgtatttgtgagactcgcaggagtccccatctgtagcacaggcaatgccagtgccatgctgcagcctcagaaaccaggcctctcactccagcagcaggcagaaccgtgtctgtggtcgggtgctgtccacagctctgtctgccttgttcttgggcttgagctggatagaggtggggtctcttcaccttccctgaattcagaacagaccctgtgcctggccccagtgtgcccaggcaattccccaggccctcactgggagcccttggtgttctgagcagcagggcccaggcagcacatgagcagtgcccaggggctccctgcgtgaggacggcaaggtgcgatgtatgtctaacttattgatggcaggcagccccctgtgccccctaagcctggccctggttattgctgagctctgtgctcagtgctgcggcctggccgtggctcgtctgttcctttggggggcccgggcgggttgtgggaatcagtcttcacagacagacgtgagccaggcggaggactcgttccttgcagaggtcagtcctcacctgcaggtgtcggggtgggggggggcaaggaggggcaggcacacaccatgtctgacctgaacccgattctggggagcatcttcccgctccggccccacgacctccacagggttacattgtaatatatatgccccagctaacctgtctgatggtggcatcttcctgcagacatttcaaacatgtaacttttatatgaaaaaaaataaacacagatgaaagctgcccaatgccaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:2889 -> Molecular function: GO:0005085 [guanyl-nucleotide exchange factor activity] evidence: IEA
            GeneID:2889 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
            GeneID:2889 -> Molecular function: GO:0017124 [SH3 domain binding] evidence: IEA
            GeneID:2889 -> Biological process: GO:0000186 [activation of MAPKK activity] evidence: TAS
            GeneID:2889 -> Biological process: GO:0001568 [blood vessel development] evidence: IEA
            GeneID:2889 -> Biological process: GO:0007165 [signal transduction] evidence: NAS
            GeneID:2889 -> Biological process: GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] evidence: TAS
            GeneID:2889 -> Biological process: GO:0007264 [small GTPase mediated signal transduction] evidence: IEA
            GeneID:2889 -> Biological process: GO:0016337 [cell-cell adhesion] evidence: IEA
            GeneID:2889 -> Biological process: GO:0048008 [platelet-derived growth factor receptor signaling pathway] evidence: IEA
            GeneID:2889 -> Biological process: GO:0048011 [neurotrophin TRK receptor signaling pathway] evidence: TAS
            GeneID:2889 -> Biological process: GO:0051056 [regulation of small GTPase mediated signal transduction] evidence: IEA
            GeneID:2889 -> Cellular component: GO:0005768 [endosome] evidence: TAS
            GeneID:2889 -> Cellular component: GO:0005829 [cytosol] evidence: TAS

by @meso_cacase at DBCLS
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