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2024-03-29 17:49:01, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_005149               2882 bp    mRNA    linear   PRI 13-APR-2013
DEFINITION  Homo sapiens T-box 19 (TBX19), mRNA.
ACCESSION   NM_005149
VERSION     NM_005149.2  GI:170671702
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2882)
  AUTHORS   Smith,C.J., Bensing,S., Burns,C., Robinson,P.J.,
            Kasperlik-Zaluska,A.A., Scott,R.J., Kampe,O. and Crock,P.A.
  TITLE     Identification of TPIT and other novel autoantigens in lymphocytic
            hypophysitis: immunoscreening of a pituitary cDNA library and
            development of immunoprecipitation assays
  JOURNAL   Eur. J. Endocrinol. 166 (3), 391-398 (2012)
   PUBMED   22193973
  REMARK    GeneRIF: TPIT is identified as a target autoantigen in 10.5% of
            patients with lymphocytic hypophysitis.
REFERENCE   2  (bases 1 to 2882)
  AUTHORS   Couture,C., Saveanu,A., Barlier,A., Carel,J.C., Fassnacht,M.,
            Fluck,C.E., Houang,M., Maes,M., Phan-Hug,F., Enjalbert,A.,
            Drouin,J., Brue,T. and Vallette,S.
  TITLE     Phenotypic homogeneity and genotypic variability in a large series
            of congenital isolated ACTH-deficiency patients with TPIT gene
            mutations
  JOURNAL   J. Clin. Endocrinol. Metab. 97 (3), E486-E495 (2012)
   PUBMED   22170728
  REMARK    GeneRIF: Identification of nine new TPIT mutations in a large
            series of congenital isolated ACTH-deficiency patients.
REFERENCE   3  (bases 1 to 2882)
  AUTHORS   Budry,L., Couture,C., Balsalobre,A. and Drouin,J.
  TITLE     The Ets factor Etv1 interacts with Tpit protein for pituitary
            pro-opiomelanocortin (POMC) gene transcription
  JOURNAL   J. Biol. Chem. 286 (28), 25387-25396 (2011)
   PUBMED   21622576
  REMARK    GeneRIF: The coordinate expression of Etv1 with POMC cell
            differentiation and its interaction with the highly cell-restricted
            Tpit factor indicate that Etv1 participates in a combinatorial code
            for pituitary cell-specific gene expression.
REFERENCE   4  (bases 1 to 2882)
  AUTHORS   Ehret,G.B., O'Connor,A.A., Weder,A., Cooper,R.S. and Chakravarti,A.
  TITLE     Follow-up of a major linkage peak on chromosome 1 reveals
            suggestive QTLs associated with essential hypertension: GenNet
            study
  JOURNAL   Eur. J. Hum. Genet. 17 (12), 1650-1657 (2009)
   PUBMED   19536175
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   5  (bases 1 to 2882)
  AUTHORS   Cheung,C.L., Chan,B.Y., Chan,V., Ikegawa,S., Kou,I., Ngai,H.,
            Smith,D., Luk,K.D., Huang,Q.Y., Mori,S., Sham,P.C. and Kung,A.W.
  TITLE     Pre-B-cell leukemia homeobox 1 (PBX1) shows functional and possible
            genetic association with bone mineral density variation
  JOURNAL   Hum. Mol. Genet. 18 (4), 679-687 (2009)
   PUBMED   19064610
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   6  (bases 1 to 2882)
  AUTHORS   Pulichino,A.M., Vallette-Kasic,S., Tsai,J.P., Couture,C.,
            Gauthier,Y. and Drouin,J.
  TITLE     Tpit determines alternate fates during pituitary cell
            differentiation
  JOURNAL   Genes Dev. 17 (6), 738-747 (2003)
   PUBMED   12651892
REFERENCE   7  (bases 1 to 2882)
  AUTHORS   Pulichino,A.M., Vallette-Kasic,S., Couture,C., Gauthier,Y.,
            Brue,T., David,M., Malpuech,G., Deal,C., Van Vliet,G., De
            Vroede,M., Riepe,F.G., Partsch,C.J., Sippell,W.G., Berberoglu,M.,
            Atasay,B. and Drouin,J.
  TITLE     Human and mouse TPIT gene mutations cause early onset pituitary
            ACTH deficiency
  JOURNAL   Genes Dev. 17 (6), 711-716 (2003)
   PUBMED   12651888
  REMARK    GeneRIF: TPIT has a role in expression of the pro-opiomelanocortin
            gene and terminal differentiation of the pituitary corticotroph
            lineage, and its mutation causes early onset pituitary ACTH
            deficiency
REFERENCE   8  (bases 1 to 2882)
  AUTHORS   Asteria,C.
  TITLE     T-box and isolated ACTH deficiency
  JOURNAL   Eur. J. Endocrinol. 146 (4), 463-465 (2002)
   PUBMED   11916612
  REMARK    GeneRIF: Review.  Association of 2 mutations with an ACTH
            deficiency is consistent with the role of tbx19 in differentiation
            of POMC cells.
            Review article
REFERENCE   9  (bases 1 to 2882)
  AUTHORS   Lamolet,B., Pulichino,A.M., Lamonerie,T., Gauthier,Y., Brue,T.,
            Enjalbert,A. and Drouin,J.
  TITLE     A pituitary cell-restricted T box factor, Tpit, activates POMC
            transcription in cooperation with Pitx homeoproteins
  JOURNAL   Cell 104 (6), 849-859 (2001)
   PUBMED   11290323
REFERENCE   10 (bases 1 to 2882)
  AUTHORS   Yi,C.H., Terrett,J.A., Li,Q.Y., Ellington,K., Packham,E.A.,
            Armstrong-Buisseret,L., McClure,P., Slingsby,T. and Brook,J.D.
  TITLE     Identification, mapping, and phylogenomic analysis of four new
            human members of the T-box gene family: EOMES, TBX6, TBX18, and
            TBX19
  JOURNAL   Genomics 55 (1), 10-20 (1999)
   PUBMED   9888994
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AJ010277.1 and AK091404.1.
            This sequence is a reference standard in the RefSeqGene project.
            On Mar 22, 2008 this sequence version replaced gi:4827023.
            
            Summary: This gene is a member of a phylogenetically conserved
            family of genes that share a common DNA-binding domain, the T-box.
            T-box genes encode transcription factors involved in the regulation
            of developmental processes. Mutations in this gene were found in
            patients with isolated deficiency of pituitary POMC-derived ACTH,
            suggesting an essential role for this gene in differentiation of
            the pituitary POMC lineage. ACTH deficiency is characterized by
            adrenal insufficiency symptoms such as weight loss, lack of
            appetite (anorexia), weakness, nausea, vomiting, and low blood
            pressure. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ010277.1, BC093664.1 [ECO:0000332]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2340              AJ010277.1         1-2340
            2341-2820           AK091404.1         2037-2516
            2821-2882           AJ010277.1         2821-2882
FEATURES             Location/Qualifiers
     source          1..2882
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q24.2"
     gene            1..2882
                     /gene="TBX19"
                     /gene_synonym="dJ747L4.1; TBS19; TPIT"
                     /note="T-box 19"
                     /db_xref="GeneID:9095"
                     /db_xref="HGNC:11596"
                     /db_xref="HPRD:05214"
                     /db_xref="MIM:604614"
     exon            1..254
                     /gene="TBX19"
                     /gene_synonym="dJ747L4.1; TBS19; TPIT"
                     /inference="alignment:Splign:1.39.8"
     misc_feature    1..3
                     /gene="TBX19"
                     /gene_synonym="dJ747L4.1; TBS19; TPIT"
                     /note="upstream in-frame stop codon"
     STS             16..1429
                     /gene="TBX19"
                     /gene_synonym="dJ747L4.1; TBS19; TPIT"
                     /db_xref="UniSTS:483486"
     variation       30
                     /gene="TBX19"
                     /gene_synonym="dJ747L4.1; TBS19; TPIT"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200517364"
     variation       31
                     /gene="TBX19"
                     /gene_synonym="dJ747L4.1; TBS19; TPIT"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:187423054"
     variation       49
                     /gene="TBX19"
                     /gene_synonym="dJ747L4.1; TBS19; TPIT"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:367613004"
     CDS             52..1398
                     /gene="TBX19"
                     /gene_synonym="dJ747L4.1; TBS19; TPIT"
                     /note="TBS 19; T-box protein 19; T-box factor, pituitary"
                     /codon_start=1
                     /product="T-box transcription factor TBX19"
                     /protein_id="NP_005140.1"
                     /db_xref="GI:4827024"
                     /db_xref="CCDS:CCDS1272.1"
                     /db_xref="GeneID:9095"
                     /db_xref="HGNC:11596"
                     /db_xref="HPRD:05214"
                     /db_xref="MIM:604614"
                     /translation="
MAMSELGTRKPSDGTVSHLLNVVESELQAGREKGDPTEKQLQIILEDAPLWQRFKEVTNEMIVTKNGRRMFPVLKISVTGLDPNAMYSLLLDFVPTDSHRWKYVNGEWVPAGKPEVSSHSCVYIHPDSPNFGAHWMKAPISFSKVKLTNKLNGGGQIMLNSLHKYEPQVHIVRVGSAHRMVTNCSFPETQFIAVTAYQNEEITALKIKYNPFAKAFLDAKERNHLRDVPEAISESQHVTYSHLGGWIFSNPDGVCTAGNSNYQYAAPLPLPAPHTHHGCEHYSGLRGHRQAPYPSAYMHRNHSPSVNLIESSSNNLQVFSGPDSWTSLSSTPHASILSVPHTNGPINPGPSPYPCLWTISNGAGGPSGPGPEVHASTPGAFLLGNPAVTSPPSVLSTQAPTSAGVEVLGEPSLTSIAVSTWTAVASHPFAGWGGPGAGGHHSPSSLDG
"
     misc_feature    169..717
                     /gene="TBX19"
                     /gene_synonym="dJ747L4.1; TBS19; TPIT"
                     /note="T-box DNA binding domain of the T-box family of
                     transcriptional regulators. The T-box family is an ancient
                     group that appears to play a critical role in development
                     in all animal species. These genes were uncovered on the
                     basis of similarity to the DNA...; Region: TBOX; cd00182"
                     /db_xref="CDD:29144"
     misc_feature    order(235..237,241..258,262..264,349..351,532..534,
                     634..642,658..660,670..672,679..705)
                     /gene="TBX19"
                     /gene_synonym="dJ747L4.1; TBS19; TPIT"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:29144"
     misc_feature    order(307..309,436..444,571..573)
                     /gene="TBX19"
                     /gene_synonym="dJ747L4.1; TBS19; TPIT"
                     /note="dimerization interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:29144"
     variation       61
                     /gene="TBX19"
                     /gene_synonym="dJ747L4.1; TBS19; TPIT"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:190633524"
     variation       76
                     /gene="TBX19"
                     /gene_synonym="dJ747L4.1; TBS19; TPIT"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:146259816"
     variation       87
                     /gene="TBX19"
                     /gene_synonym="dJ747L4.1; TBS19; TPIT"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:144173772"
     variation       112
                     /gene="TBX19"
                     /gene_synonym="dJ747L4.1; TBS19; TPIT"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:372107667"
     variation       113
                     /gene="TBX19"
                     /gene_synonym="dJ747L4.1; TBS19; TPIT"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:149094298"
     variation       133
                     /gene="TBX19"
                     /gene_synonym="dJ747L4.1; TBS19; TPIT"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:202179787"
     variation       156
                     /gene="TBX19"
                     /gene_synonym="dJ747L4.1; TBS19; TPIT"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:34284181"
     variation       197
                     /gene="TBX19"
                     /gene_synonym="dJ747L4.1; TBS19; TPIT"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:138336580"
     exon            255..519
                     /gene="TBX19"
                     /gene_synonym="dJ747L4.1; TBS19; TPIT"
                     /inference="alignment:Splign:1.39.8"
     variation       308
                     /gene="TBX19"
                     /gene_synonym="dJ747L4.1; TBS19; TPIT"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:74315378"
     variation       312
                     /gene="TBX19"
                     /gene_synonym="dJ747L4.1; TBS19; TPIT"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:376338008"
     variation       338
                     /gene="TBX19"
                     /gene_synonym="dJ747L4.1; TBS19; TPIT"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:138884950"
     variation       339
                     /gene="TBX19"
                     /gene_synonym="dJ747L4.1; TBS19; TPIT"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:376493164"
     variation       349
                     /gene="TBX19"
                     /gene_synonym="dJ747L4.1; TBS19; TPIT"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:369516206"
     variation       366
                     /gene="TBX19"
                     /gene_synonym="dJ747L4.1; TBS19; TPIT"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:143801899"
     variation       378
                     /gene="TBX19"
                     /gene_synonym="dJ747L4.1; TBS19; TPIT"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201089616"
     variation       381
                     /gene="TBX19"
                     /gene_synonym="dJ747L4.1; TBS19; TPIT"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:148222296"
     variation       402
                     /gene="TBX19"
                     /gene_synonym="dJ747L4.1; TBS19; TPIT"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200376346"
     variation       414
                     /gene="TBX19"
                     /gene_synonym="dJ747L4.1; TBS19; TPIT"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:373440757"
     variation       420
                     /gene="TBX19"
                     /gene_synonym="dJ747L4.1; TBS19; TPIT"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:112910251"
     variation       432
                     /gene="TBX19"
                     /gene_synonym="dJ747L4.1; TBS19; TPIT"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:369030642"
     variation       434
                     /gene="TBX19"
                     /gene_synonym="dJ747L4.1; TBS19; TPIT"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:74315377"
     variation       436
                     /gene="TBX19"
                     /gene_synonym="dJ747L4.1; TBS19; TPIT"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:200208381"
     variation       439
                     /gene="TBX19"
                     /gene_synonym="dJ747L4.1; TBS19; TPIT"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:142648227"
     variation       440
                     /gene="TBX19"
                     /gene_synonym="dJ747L4.1; TBS19; TPIT"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:372115950"
     variation       511
                     /gene="TBX19"
                     /gene_synonym="dJ747L4.1; TBS19; TPIT"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:375592995"
     variation       513
                     /gene="TBX19"
                     /gene_synonym="dJ747L4.1; TBS19; TPIT"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:34342577"
     exon            520..654
                     /gene="TBX19"
                     /gene_synonym="dJ747L4.1; TBS19; TPIT"
                     /inference="alignment:Splign:1.39.8"
     variation       534
                     /gene="TBX19"
                     /gene_synonym="dJ747L4.1; TBS19; TPIT"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:199559734"
     variation       535
                     /gene="TBX19"
                     /gene_synonym="dJ747L4.1; TBS19; TPIT"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:368646786"
     variation       568
                     /gene="TBX19"
                     /gene_synonym="dJ747L4.1; TBS19; TPIT"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:371934190"
     variation       586
                     /gene="TBX19"
                     /gene_synonym="dJ747L4.1; TBS19; TPIT"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200197424"
     variation       587
                     /gene="TBX19"
                     /gene_synonym="dJ747L4.1; TBS19; TPIT"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:139968594"
     variation       630
                     /gene="TBX19"
                     /gene_synonym="dJ747L4.1; TBS19; TPIT"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:376849434"
     variation       648
                     /gene="TBX19"
                     /gene_synonym="dJ747L4.1; TBS19; TPIT"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:143377172"
     exon            655..716
                     /gene="TBX19"
                     /gene_synonym="dJ747L4.1; TBS19; TPIT"
                     /inference="alignment:Splign:1.39.8"
     variation       660
                     /gene="TBX19"
                     /gene_synonym="dJ747L4.1; TBS19; TPIT"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199994044"
     variation       678
                     /gene="TBX19"
                     /gene_synonym="dJ747L4.1; TBS19; TPIT"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:140528998"
     exon            717..778
                     /gene="TBX19"
                     /gene_synonym="dJ747L4.1; TBS19; TPIT"
                     /inference="alignment:Splign:1.39.8"
     variation       733
                     /gene="TBX19"
                     /gene_synonym="dJ747L4.1; TBS19; TPIT"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:373113854"
     variation       744
                     /gene="TBX19"
                     /gene_synonym="dJ747L4.1; TBS19; TPIT"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:141612171"
     variation       747
                     /gene="TBX19"
                     /gene_synonym="dJ747L4.1; TBS19; TPIT"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:202067639"
     variation       761
                     /gene="TBX19"
                     /gene_synonym="dJ747L4.1; TBS19; TPIT"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201741262"
     variation       775
                     /gene="TBX19"
                     /gene_synonym="dJ747L4.1; TBS19; TPIT"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:202072731"
     exon            779..967
                     /gene="TBX19"
                     /gene_synonym="dJ747L4.1; TBS19; TPIT"
                     /inference="alignment:Splign:1.39.8"
     variation       811
                     /gene="TBX19"
                     /gene_synonym="dJ747L4.1; TBS19; TPIT"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:145383177"
     variation       812
                     /gene="TBX19"
                     /gene_synonym="dJ747L4.1; TBS19; TPIT"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:77425733"
     variation       847
                     /gene="TBX19"
                     /gene_synonym="dJ747L4.1; TBS19; TPIT"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:368059098"
     variation       873
                     /gene="TBX19"
                     /gene_synonym="dJ747L4.1; TBS19; TPIT"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:141383527"
     variation       900
                     /gene="TBX19"
                     /gene_synonym="dJ747L4.1; TBS19; TPIT"
                     /replace="a"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:145436332"
     variation       907
                     /gene="TBX19"
                     /gene_synonym="dJ747L4.1; TBS19; TPIT"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:74315376"
     variation       918
                     /gene="TBX19"
                     /gene_synonym="dJ747L4.1; TBS19; TPIT"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:149773867"
     variation       948
                     /gene="TBX19"
                     /gene_synonym="dJ747L4.1; TBS19; TPIT"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:149005522"
     exon            968..1103
                     /gene="TBX19"
                     /gene_synonym="dJ747L4.1; TBS19; TPIT"
                     /inference="alignment:Splign:1.39.8"
     variation       988
                     /gene="TBX19"
                     /gene_synonym="dJ747L4.1; TBS19; TPIT"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:368259445"
     variation       1045
                     /gene="TBX19"
                     /gene_synonym="dJ747L4.1; TBS19; TPIT"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:146602640"
     variation       1076
                     /gene="TBX19"
                     /gene_synonym="dJ747L4.1; TBS19; TPIT"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:372264894"
     variation       1079
                     /gene="TBX19"
                     /gene_synonym="dJ747L4.1; TBS19; TPIT"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:137938456"
     variation       1080
                     /gene="TBX19"
                     /gene_synonym="dJ747L4.1; TBS19; TPIT"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:141608452"
     variation       1087
                     /gene="TBX19"
                     /gene_synonym="dJ747L4.1; TBS19; TPIT"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:113436244"
     exon            1104..2822
                     /gene="TBX19"
                     /gene_synonym="dJ747L4.1; TBS19; TPIT"
                     /inference="alignment:Splign:1.39.8"
     variation       1113
                     /gene="TBX19"
                     /gene_synonym="dJ747L4.1; TBS19; TPIT"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:77017796"
     variation       1123
                     /gene="TBX19"
                     /gene_synonym="dJ747L4.1; TBS19; TPIT"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200410315"
     variation       1140
                     /gene="TBX19"
                     /gene_synonym="dJ747L4.1; TBS19; TPIT"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:369468092"
     variation       1141
                     /gene="TBX19"
                     /gene_synonym="dJ747L4.1; TBS19; TPIT"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199644548"
     variation       1147
                     /gene="TBX19"
                     /gene_synonym="dJ747L4.1; TBS19; TPIT"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:373407654"
     variation       1153
                     /gene="TBX19"
                     /gene_synonym="dJ747L4.1; TBS19; TPIT"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:138278388"
     variation       1163
                     /gene="TBX19"
                     /gene_synonym="dJ747L4.1; TBS19; TPIT"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:138080739"
     variation       1164
                     /gene="TBX19"
                     /gene_synonym="dJ747L4.1; TBS19; TPIT"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:374611735"
     variation       1173
                     /gene="TBX19"
                     /gene_synonym="dJ747L4.1; TBS19; TPIT"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:34885709"
     variation       1174
                     /gene="TBX19"
                     /gene_synonym="dJ747L4.1; TBS19; TPIT"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:76536877"
     variation       1179
                     /gene="TBX19"
                     /gene_synonym="dJ747L4.1; TBS19; TPIT"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:142374002"
     variation       1183
                     /gene="TBX19"
                     /gene_synonym="dJ747L4.1; TBS19; TPIT"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:377712241"
     variation       1189
                     /gene="TBX19"
                     /gene_synonym="dJ747L4.1; TBS19; TPIT"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:370573055"
     variation       1198
                     /gene="TBX19"
                     /gene_synonym="dJ747L4.1; TBS19; TPIT"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200775601"
     variation       1200
                     /gene="TBX19"
                     /gene_synonym="dJ747L4.1; TBS19; TPIT"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:139271595"
     variation       1216
                     /gene="TBX19"
                     /gene_synonym="dJ747L4.1; TBS19; TPIT"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:144416092"
     variation       1232
                     /gene="TBX19"
                     /gene_synonym="dJ747L4.1; TBS19; TPIT"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:376855161"
     variation       1256
                     /gene="TBX19"
                     /gene_synonym="dJ747L4.1; TBS19; TPIT"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:370560582"
     variation       1257
                     /gene="TBX19"
                     /gene_synonym="dJ747L4.1; TBS19; TPIT"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:373913285"
     variation       1260
                     /gene="TBX19"
                     /gene_synonym="dJ747L4.1; TBS19; TPIT"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:368420917"
     variation       1262
                     /gene="TBX19"
                     /gene_synonym="dJ747L4.1; TBS19; TPIT"
                     /replace="a"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:146641804"
     variation       1268
                     /gene="TBX19"
                     /gene_synonym="dJ747L4.1; TBS19; TPIT"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:146860116"
     variation       1275
                     /gene="TBX19"
                     /gene_synonym="dJ747L4.1; TBS19; TPIT"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:149058755"
     variation       1328
                     /gene="TBX19"
                     /gene_synonym="dJ747L4.1; TBS19; TPIT"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:148791684"
     variation       1329
                     /gene="TBX19"
                     /gene_synonym="dJ747L4.1; TBS19; TPIT"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200161002"
     variation       1338
                     /gene="TBX19"
                     /gene_synonym="dJ747L4.1; TBS19; TPIT"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:370679374"
     variation       1340
                     /gene="TBX19"
                     /gene_synonym="dJ747L4.1; TBS19; TPIT"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:189380651"
     variation       1345
                     /gene="TBX19"
                     /gene_synonym="dJ747L4.1; TBS19; TPIT"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:201988334"
     variation       1361
                     /gene="TBX19"
                     /gene_synonym="dJ747L4.1; TBS19; TPIT"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:147003438"
     variation       1369
                     /gene="TBX19"
                     /gene_synonym="dJ747L4.1; TBS19; TPIT"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:182020232"
     variation       1383
                     /gene="TBX19"
                     /gene_synonym="dJ747L4.1; TBS19; TPIT"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:34997986"
     variation       1419
                     /gene="TBX19"
                     /gene_synonym="dJ747L4.1; TBS19; TPIT"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:3885717"
     variation       1424
                     /gene="TBX19"
                     /gene_synonym="dJ747L4.1; TBS19; TPIT"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:143627386"
     variation       1437
                     /gene="TBX19"
                     /gene_synonym="dJ747L4.1; TBS19; TPIT"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:183737051"
     variation       1584
                     /gene="TBX19"
                     /gene_synonym="dJ747L4.1; TBS19; TPIT"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:10918869"
     variation       1649
                     /gene="TBX19"
                     /gene_synonym="dJ747L4.1; TBS19; TPIT"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1000533"
     variation       1665
                     /gene="TBX19"
                     /gene_synonym="dJ747L4.1; TBS19; TPIT"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:146307337"
     variation       1769
                     /gene="TBX19"
                     /gene_synonym="dJ747L4.1; TBS19; TPIT"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:188457637"
     variation       1867
                     /gene="TBX19"
                     /gene_synonym="dJ747L4.1; TBS19; TPIT"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:16860362"
     variation       1877
                     /gene="TBX19"
                     /gene_synonym="dJ747L4.1; TBS19; TPIT"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:1003315"
     variation       1942
                     /gene="TBX19"
                     /gene_synonym="dJ747L4.1; TBS19; TPIT"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:144304383"
     variation       1952
                     /gene="TBX19"
                     /gene_synonym="dJ747L4.1; TBS19; TPIT"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:181087534"
     variation       1965
                     /gene="TBX19"
                     /gene_synonym="dJ747L4.1; TBS19; TPIT"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:115894164"
     variation       1982
                     /gene="TBX19"
                     /gene_synonym="dJ747L4.1; TBS19; TPIT"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:114399220"
     variation       1993
                     /gene="TBX19"
                     /gene_synonym="dJ747L4.1; TBS19; TPIT"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:117863071"
     variation       2094
                     /gene="TBX19"
                     /gene_synonym="dJ747L4.1; TBS19; TPIT"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:151060403"
     variation       2221
                     /gene="TBX19"
                     /gene_synonym="dJ747L4.1; TBS19; TPIT"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:186602506"
     variation       2317..2320
                     /gene="TBX19"
                     /gene_synonym="dJ747L4.1; TBS19; TPIT"
                     /replace=""
                     /replace="aaag"
                     /db_xref="dbSNP:145923688"
     variation       2317
                     /gene="TBX19"
                     /gene_synonym="dJ747L4.1; TBS19; TPIT"
                     /replace=""
                     /replace="aaag"
                     /db_xref="dbSNP:10558612"
     variation       2320..2323
                     /gene="TBX19"
                     /gene_synonym="dJ747L4.1; TBS19; TPIT"
                     /replace=""
                     /replace="gaaa"
                     /db_xref="dbSNP:67726248"
     variation       2320
                     /gene="TBX19"
                     /gene_synonym="dJ747L4.1; TBS19; TPIT"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:76137849"
     variation       2334
                     /gene="TBX19"
                     /gene_synonym="dJ747L4.1; TBS19; TPIT"
                     /replace=""
                     /replace="agaa"
                     /db_xref="dbSNP:35636083"
     variation       2352
                     /gene="TBX19"
                     /gene_synonym="dJ747L4.1; TBS19; TPIT"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:140853969"
     variation       2553
                     /gene="TBX19"
                     /gene_synonym="dJ747L4.1; TBS19; TPIT"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:77202012"
     STS             2601..2733
                     /gene="TBX19"
                     /gene_synonym="dJ747L4.1; TBS19; TPIT"
                     /standard_name="G35325"
                     /db_xref="UniSTS:24617"
     variation       2632
                     /gene="TBX19"
                     /gene_synonym="dJ747L4.1; TBS19; TPIT"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:149712948"
     variation       2633
                     /gene="TBX19"
                     /gene_synonym="dJ747L4.1; TBS19; TPIT"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:112010969"
     variation       2649
                     /gene="TBX19"
                     /gene_synonym="dJ747L4.1; TBS19; TPIT"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:377117067"
     variation       2795
                     /gene="TBX19"
                     /gene_synonym="dJ747L4.1; TBS19; TPIT"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:191452002"
     polyA_signal    2801..2806
                     /gene="TBX19"
                     /gene_synonym="dJ747L4.1; TBS19; TPIT"
     polyA_site      2822
                     /gene="TBX19"
                     /gene_synonym="dJ747L4.1; TBS19; TPIT"
ORIGIN      
tagaagcaggcaagttgggtaacggctctcggcaaagttcgagaagtgcctatggccatgagtgagctgggcactcggaagcccagcgatggcactgtttctcatctgctcaatgtggtggagagtgagcttcaggcagggagggaaaaaggcgaccctacggagaagcaacttcagatcatcctggaggatgcacctctctggcagagattcaaggaagtcactaatgagatgattgtgaccaagaatggcagacggatgtttccagtcctaaagattagtgtcacagggttggaccccaatgccatgtactccctcctgctggactttgtccctacggacagtcaccgctggaagtacgtcaacggggaatgggtgcccgctggcaagccagaggtctccagccacagctgcgtctacattcacccggactcccccaactttggggcccactggatgaaagctcccatctccttcagcaaagtgaagctgaccaacaagctcaatggaggcgggcagataatgttgaattctctgcataaatatgaaccccaggttcacatagtgcgtgttggaagtgcccatcgaatggtaacaaactgctccttccctgaaacccagttcatagccgtgactgcctatcagaatgaggagataacggctctcaaaatcaagtacaatccttttgccaaagccttcttggatgccaaggaaagaaatcacctaagagacgtaccggaggctatctctgagagccagcatgtgacctattctcacttgggaggctggatcttttccaatccagatggagtgtgcacagcaggaaactccaattaccagtatgccgctcctctgcctctgcctgctccccacacccaccatggctgtgagcactattcgggtctccgaggacaccggcaggctccctacccttctgcgtacatgcacagaaaccattctccctcagtgaatttgatagaaagctcaagcaataatctgcaagttttctcgggacctgacagctggacttccttatcctccacaccccatgccagcatcctgtctgtaccccacaccaacggaccaatcaatccagggcccagcccctacccgtgcctgtggaccatcagcaatggtgccggaggccccagtgggccaggcccggaggtgcacgccagcaccccaggagcatttctcctcggaaacccagctgtgacttcacccccttctgtgctctccacccaagcacccacttcggctggtgtggaggttctgggggagccctcgctaaccagcattgctgtgtccacctggacagcagtggcctcgcatcccttcgcgggctggggtggcccaggagcgggtgggcaccattctccttcctcactggatggttaagcaggatcctaggagcctctttgcacagcgatccttccatgtgtagagtgcttagaaaccccatcaactgatctagtgagtcagactgtggaatctcccttcccactagctggaggtggaggtgggttattacagaagtcatactgggagagggttcagtttggatgatgctagttagatcatttgcatctctccaccattttcttctgcactcccattttctctgcagcttattcttgccatgcttaggtgacagaagtttgttaagtaccatccttgtgccctgcctcttattctcaaatcgttctggaaagcctcacttccttttctgtggagaaggtgcaaagctgttaaatgagctcagagtttacctagctaaggccactgcttcctgctttgtgaagcctggaaagtatgtgtggccacagggctcaggttcacacttctgctttgagaccaggatggggtgtaagccatagagtaaggttaacaaaaagaataaagctaatcatgtattacaaacagcagtgtgcccagacttgtggaaatgaagtcatgtcactcctctgctcagaaaccttcaatggttcaccattaccagtggaatgaagtcaattctcctcactataactgggtgtggtagtttaagcctataatctcagcccttttggaggccaaggtaagaggatcgcttgaggtcaggagttcgagaccagcttgtgcaacaaagtgagagcctgtctctacaaaaaatagtcatgcacacaaaattagctgggcatggtggcctgtgcctatagtcccaactacttagaggaggatcgcttgatctcaggaggttgaggctgcagtgaattatgattgtggcattgcactccagcctgggtggtagatcaaggctttgtttcatttgaaaaaaaagaaagaaagaaagaaagaaagaaatcctactacgagcgatcacaccatctggcctgaaaccacttccccagcttaggtccctctgttatcctgttggcctcctatgtattggtcaaggcaggcatctctgttctctgaacattcattgcactttcccacctctataccttgcctgtgccttagtgtcctcttttttccagttcacctgtgcgaatccgacccacctcccagagcctggctgaaacgtcactccctgcatccaacatctgatctgctgagatatgtctgatctatctctgctcgctgttctcccgttgtttttgcctctgccatagagctcacctcattttgccttgtatttttgttacctgtgagtgtgtctctccctattagactgtaagcctctcgagggtgaggcctagccttcttgtctttgtaacccacagcagctggtactgtgccttgcctattgtaggtgcccaataaacatttgctgaactgaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:9095 -> Molecular function: GO:0001158 [enhancer sequence-specific DNA binding] evidence: IEA
            GeneID:9095 -> Molecular function: GO:0003700 [sequence-specific DNA binding transcription factor activity] evidence: IEA
            GeneID:9095 -> Biological process: GO:0006351 [transcription, DNA-dependent] evidence: IEA
            GeneID:9095 -> Biological process: GO:0006357 [regulation of transcription from RNA polymerase II promoter] evidence: TAS
            GeneID:9095 -> Biological process: GO:0009653 [anatomical structure morphogenesis] evidence: TAS
            GeneID:9095 -> Biological process: GO:0021983 [pituitary gland development] evidence: IEA
            GeneID:9095 -> Biological process: GO:0042127 [regulation of cell proliferation] evidence: IEA
            GeneID:9095 -> Biological process: GO:0045165 [cell fate commitment] evidence: IEA
            GeneID:9095 -> Biological process: GO:0045595 [regulation of cell differentiation] evidence: IEA
            GeneID:9095 -> Biological process: GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] evidence: IEA
            GeneID:9095 -> Cellular component: GO:0005634 [nucleus] evidence: IEA

by @meso_cacase at DBCLS
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